|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
25-421 |
7.35e-96 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 291.78 E-value: 7.35e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 25 LVLLFMAGIVNFLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQAL 104
Cdd:cd17319 5 IPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTAL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 105 TGMVNSFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVIIG 184
Cdd:cd17319 85 TGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 185 VAGILVGICWYAWYRNraqfvltdeertylsapvkprpqlqfsewlalfkhrtTWGMILGFSGVNYTGWLYIAWLPGYLQ 264
Cdd:cd17319 165 LLGLLLAVLWWFYLRQ-------------------------------------VWGLALGYFGINYALYGLLTWLPTYLK 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 265 AEQGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRLakkgydLAKTRKTAIVCGLMMSALGTLLVVQSSSPAQAVAFISMA 344
Cdd:cd17319 208 QARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRL------LRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLA 281
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1618847556 345 LFCVHFAGTSAWGLVQVMVSETKVASIAGIQNFGSFVFASFAPIVTGWVVDTTHSFNLALVIAACVTFTGALCYFFI 421
Cdd:cd17319 282 GFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
15-425 |
4.00e-75 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 238.62 E-value: 4.00e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 15 QRIRRIQTVTLVLLFMAGIVNFLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAG 94
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 95 LIFWSLMQALTGMVNSFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAW 174
Cdd:COG2271 82 LLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 175 GWRTMFVIIGVAGILVGICwyawyrnraqfvltdeertylsapvkprpqlqfsewlalfkhrTTWGMILGFSGVNYTGWL 254
Cdd:COG2271 162 GWRAAFLILGLPGLLLALL-------------------------------------------RFWLLALAYFLVYFALYG 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 255 YIAWLPGYLQAEQGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRLAKKgydlaktRKTAIVCGLMMSALGTLLVVQSSSP 334
Cdd:COG2271 199 FLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR-------RKLVLAIGLLLAALALLLLALLPSP 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 335 AQAVAFISMALFCVHFAGTSAWGLVQVMVSETKVASIAGIQNFGSFVFASFAPIVTGWVVDTTHsFNLALVIAACVTFTG 414
Cdd:COG2271 272 ALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLA 350
|
410
....*....|.
gi 1618847556 415 ALCYFFIVKDR 425
Cdd:COG2271 351 ALLALLLLRET 361
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
30-422 |
2.37e-72 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 232.61 E-value: 2.37e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 30 MAGIVNFLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGMVN 109
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 110 SFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVIIGVAGIL 189
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGII 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 190 VGICWYAWYRNRAQ--FVLTDEERTYLS------APVKPRPQLQFSEWLALFKHRTTWGMILGFSGVNYTGWLYIAWLPG 261
Cdd:TIGR00893 161 WGVLWLKFIPDPPQkaKWLTEEEKYIVVggllaeQQGKGPSTPKKYQIKELLKDRRVWGLALGQFLVNIGLGFFLTWFPT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 262 YLQAEQGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRLAKKGYDLAKTRKTAIVCGlMMSALGTLLVVQSSSPAQAVAFI 341
Cdd:TIGR00893 241 YLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAIIAG-LVLSLLMFATNYVNIPYAALALV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 342 SMALFCvHFAGTSAWGLVQVMVSETKVASIAGIQNFGSFVFASFAPIVTGWVVDTTHSFNLALVIAACVTFTGALCYFFI 421
Cdd:TIGR00893 320 ALGFFG-LGAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAALALIGALSYLLL 398
|
.
gi 1618847556 422 V 422
Cdd:TIGR00893 399 V 399
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
19-421 |
4.36e-57 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 192.40 E-value: 4.36e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 19 RIQTVTLVLLFMAGIVNFLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFW 98
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 99 SLMQALTGMVNSFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRT 178
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 179 MFVIIGVAGILVGICWYAWYRNRAQFVLTDEERTylsapvkprpqlqFSEWLALFKHRTTWGMILGFSGVNYTGWLYIAW 258
Cdd:COG2223 161 AFLILGILLLVVAVLAWLFLRDPPAGAAAAAKAS-------------LRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSW 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 259 LPGYLQAEQGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRLAKkgydlaktRKTAIVCGLMMSALGTLLVVQSSSPAQAV 338
Cdd:COG2223 228 LPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGG--------RRVLLIVFALMALGLLLLALALGSLWLFL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 339 AFISMALFCVHFAGTSAWGLVQVMVSETKVASIAGIQNFGSFVFASFAPIVTGWVVDTTHSFNLALVIAACVTFTGALCY 418
Cdd:COG2223 300 VLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLT 379
|
...
gi 1618847556 419 FFI 421
Cdd:COG2223 380 LLL 382
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
26-420 |
3.11e-44 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 157.72 E-value: 3.11e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 26 VLLFMAGIVNFLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALT 105
Cdd:cd17380 2 ILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 106 GMV--NSFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVII 183
Cdd:cd17380 82 PLLaySSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 184 GVAGILVGICWYawyrnraqfvltdeertYLSAPVkprpqlqfsewlalfkhrttWGMILGFSGVNYTGWLYIAWLPGYL 263
Cdd:cd17380 162 GLLGLLWALVWL-----------------IYLPPV--------------------WAIIVAHFCMNWGFYILLSWLPTYF 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 264 QaEQGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRLAKKGYDLAKTRKTAIVCGLMMSALGTLLVVQSSSPAQAVAFISM 343
Cdd:cd17380 205 H-EVLVPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQSIGFLGPALFLLLLSHTDSFSLALLCMSV 283
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1618847556 344 ALFCVHFagTSAWGLVQVM-VSETKVASIAGIQNFGSFVFASFAPIVTGWVVDTTHSFNLALVIAACVTFTGALCYFF 420
Cdd:cd17380 284 ALGLSAF--SSSGVLVNHQdIAPNYAGIVFGISNTAGTIPGIVGVYLTGYILEATGSWSLVFVLAAVVNLVGAVVFLL 359
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
36-398 |
1.84e-41 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 150.99 E-value: 1.84e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 36 FLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGMVNSFSHFI 115
Cdd:TIGR00881 8 YLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 116 LMRIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVL-MQLAWGWRTMFVIIGVAGILVGICW 194
Cdd:TIGR00881 88 ALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFgIAELYSWHWVFIVPGIIAIIVSLIC 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 195 YAWYRNRAQFV-LTDEERTYLSAPVKPRPQLQ--FSEWLALFK----HRTTWGMILGFSGVNYTGWLYIAWLPGYLQAEQ 267
Cdd:TIGR00881 168 FLLLRDSPQSCgLPPAEEMPNEEPDGDAEKKEeeLTKKQIFLQyvllNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEK 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 268 GFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRLAK-KGYDLAKTRKtaivCGLMMSALGTLLVVQSSSPAQAVAFISMALF 346
Cdd:TIGR00881 248 GFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNgRRGPLAVFFM----ALIIVSLLVYWLNPAANPLMDLICLFALGFL 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1618847556 347 CvhFAGTSAWGLVQVMVSETK-VASIAGIQNFGSFVFASFAPIVTGWVVDTTH 398
Cdd:TIGR00881 324 V--YGPQMLIGVIASELAPKKaAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
18-384 |
3.02e-39 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 143.96 E-value: 3.02e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 18 RRIQTVTLVLLFMAGIVNFLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIF 97
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 98 WSLMQALTGMVNSFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWR 177
Cdd:COG2814 85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 178 TMFVIIGVAGILVGICWYAWyrnraqfvltdeertyLSAPVKPRPQLQFSEWLALFKHRTTWGMILGFSGVNYTGWLYIA 257
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRL----------------LPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFT 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 258 WLPGYLQAEQGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRLAkkgydlaktRKTAIVCGLMMSALGTLLVVQSSSPAQA 337
Cdd:COG2814 229 YLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFG---------RRRLLLIGLLLLALGLLLLALAGSLWLL 299
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1618847556 338 VAFISMALFCVHFAGTSAWGLVQVMVSETKVASIAGIQNFGSFVFAS 384
Cdd:COG2814 300 LLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
25-419 |
2.78e-36 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 137.37 E-value: 2.78e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 25 LVLLFMAGIVNFLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQAL 104
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 105 TGMVNSFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLM-QLAWGWRTMFVII 183
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVaQATGGWRWAFRVT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 184 GVAGILVGICwyawyrnraqFVLTDEERTYLSAPVKPRPQLQFSEWL----ALFKHRTTWGMILGFSGVNYTGWLYIAWL 259
Cdd:cd17328 161 GVLGVLLAIL----------LLLFVREPPRGAAEGGVMAKSTATSFLadlkALAKNPSFILSTLGFTAVSFVTGALAFWA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 260 PGYLQ---AEQGFSLAKTGWVA-AIPFLAAAVGMWVNGIVVDRLAKKGydlakTRKTAIVC--GLMMSA----LGTLLVV 329
Cdd:cd17328 231 PTFFLrafGVGDLSSADVGLIFgAITCIAGVLGVLLGGILADRLRRKT-----PRADPLVCavGLLAAApflfLALVLAL 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 330 QSSSPAQAVAFISMALFCVHFAGTSAwgLVQVMVSETKVASIAGIQNFGSFVFASFA-PIVTGWVVDTTH---------- 398
Cdd:cd17328 306 SNLLLAWVLLFLGEFLLSLNWAPVFA--ILLYVVIPTRRSTASAIQILLSHLLGDAGsPYLIGLISDLLRqnkdsplaea 383
|
410 420
....*....|....*....|..
gi 1618847556 399 -SFNLALVIAACVTFTGALCYF 419
Cdd:cd17328 384 aSLQYALLLCSFVLVLGGFFFL 405
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
28-387 |
3.27e-35 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 132.93 E-value: 3.27e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 28 LFMAGIVNFLDRSSLSVA-GEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTG 106
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPAlPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 107 MVNSFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVIIGVA 186
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 187 GILVGICWYAWyrnraqfvlTDEERTYLSAPVKPRPQLQFSEWLALFKHRTTWgMILGFSGVNYTGWLYIAWLPGYLQaE 266
Cdd:pfam07690 161 SLLAAVLLLLP---------RPPPESKRPKPAEEARLSLIVAWKALLRDPVLW-LLLALLLFGFAFFGLLTYLPLYQE-V 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 267 QGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRLAKkgydlaKTRKTAIVCGLMMSALGTLLVVQSSSPAQAVAFISMALF 346
Cdd:pfam07690 230 LGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGR------RRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGF 303
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1618847556 347 CVHFAGTSAWGLVQVMVSETKVASIAGIQNFGSFVFASFAP 387
Cdd:pfam07690 304 GFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
28-410 |
1.29e-34 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 132.36 E-value: 1.29e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 28 LFMAGIVNFLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGM 107
Cdd:cd17475 1 ATLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 108 VNSFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVIIGVAG 187
Cdd:cd17475 81 VGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 188 ILVGICWYAWYRNRAQFvltdeertylsAPVKPRPQLQFSEWLALFKHRTTWgmILGFSGVNYTG--WLYIAWLPGYLQA 265
Cdd:cd17475 161 ILAAVLFWLFYREPPAA-----------SAATESASTLLRSLKEVLRNRDVW--LIAIAGALLVApqFALLTFLLLFLHD 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 266 EQGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRLakkgydLAKTRKTAIVCgLMMSALGTLLVVQSSSPAQAVAFIsMAL 345
Cdd:cd17475 228 HLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRV------FGGRRRPVLVI-TAAIAAAALLVLSLLSPGTPLWLL-VLL 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1618847556 346 FCVHFAGTSAWG-----LVQVMVSETKVASIAGIQNFGSFVFASFAPIVTGWVVDTTHSFNLA-LVIAACV 410
Cdd:cd17475 300 LILLGLFAIGWNglyltLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAwLALALLL 370
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
7-427 |
3.49e-32 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 125.76 E-value: 3.49e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 7 TSVAGNKPQRIRRIQTVTLVLLFMAGIVNFLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFG 86
Cdd:COG2807 2 STTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 87 PRIVLGAGLIFWSLMQALTGMVNSFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQKeRGTALGIFNSSTVIGQAIAPPA 166
Cdd:COG2807 82 LERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 167 LVLMQLAWGWRTMFVIIGVAGILVGICWYAWYRNRaqfvltdeertylsaPVKPRPQLQFSEWLALFKHRTTWGMILGFS 246
Cdd:COG2807 161 TVPLAAALGWRGALAVWALLALLALLLWLPLLRRR---------------PAAAAAAPAAASLRSLWRSPLAWLLTLFFG 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 247 GVNYTGWLYIAWLPGYLQaEQGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRLAKKgydlaktRKTAIVCGLMM-SALGT 325
Cdd:COG2807 226 LQSLLYYAVVAWLPPILR-DAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDR-------RPLLLLLGLLGlAGLLG 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 326 LLVVQSSSPAQAVAFISMALfcvhfAGTSAWGLVQVMV---SETKVASIAGIQNFGSFVFASFAPIVTGWVVDTTHSFNL 402
Cdd:COG2807 298 LLLAPGSLPWLWAVLLGLGQ-----GGLFPLALTLIGLrarTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTA 372
|
410 420
....*....|....*....|....*
gi 1618847556 403 ALVIAACVTFTGALCYFFIVKDRIE 427
Cdd:COG2807 373 ALLLLAALAVLMLVAGLLAGRPYVE 397
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
28-419 |
3.39e-31 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 122.92 E-value: 3.39e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 28 LFMAGIVNFLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGM 107
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 108 VNSFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPA--LVLMQLAWGWRTMFVIIGV 185
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLggILASSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 186 AGILVGICWYAWYRnraqfvltDEERTYLSAPVKPRPQLQFSEWLALFKHRTTWGMILGFSGVNYTGWLYIAWLPGYLQA 265
Cdd:cd06174 161 LALLAAILLLLVVP--------DPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLD 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 266 EQGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRLakkgydlaKTRKTAIVCGLMMSALGTLLVVQSSSPAQAVAFISMAL 345
Cdd:cd06174 233 LGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRL--------IGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLG 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1618847556 346 FCVHFAGTSAWGLVQVMVSETKVASIAGIQNFGSFVFASFAPIVTGWVVDTTHSFNLALVIAACVTFTGALCYF 419
Cdd:cd06174 305 FGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
25-379 |
1.63e-30 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 121.59 E-value: 1.63e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 25 LVLLFMAGIVNFLDRSSLSVAgeAIRG---ELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLM 101
Cdd:cd17327 7 LPLLCILYFLQYLDKSNISNA--AVMGmkeDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 102 QALTGMVNSFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPpalvLMQLAW------- 174
Cdd:cd17327 85 TLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGG----LLAYGVfkilgvg 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 175 ---GWRTMFVIIGVAGILVGICWYAWYRN---RAQFvLTDEERTYLSAPVKPRPQ------LQFSEWLALFKHRTTWGMI 242
Cdd:cd17327 161 glaGWRWLFIIEGLITIIIGLVIFFWLPDnpsKAWF-LTEEEKELAVERLRANQTgkgdqkFKWKQIKEAFKDPRTWLLF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 243 LGFSGVNYTGWLYIAWLPGyLQAEQGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRLAKKGYDLAKTRKTAIVCGLMMSA 322
Cdd:cd17327 240 LFFFCSQITNNGISNFLPL-ILKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLALVGSIILLA 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1618847556 323 LgtllvvQSSSPAQAVAFISMALFCVHFAGTSAWgLVQVMVSETKVASIAGIQNFGS 379
Cdd:cd17327 319 A------PNPPGAYFAAYILGGGSYAGFPILLSW-ISSNCAGYTKRATVLAIMLIFY 368
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
52-422 |
2.34e-30 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 120.37 E-value: 2.34e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 52 ELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGMVNSFSHFILMRIGLGIGEAPFMPA 131
Cdd:cd17325 25 SLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 132 GVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVIIGVAGILVGICwyawyrnrAQFVLTDEER 211
Cdd:cd17325 105 AMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVL--------ALLLLPEPRP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 212 TylSAPVKPRPQLQFSEWLALFKHRTTWGMILGFSGVNYTGWLYIAWLPGYLQAEQGFSLAKTGWVAAIPFLAAAVGMWV 291
Cdd:cd17325 177 P--PNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPP 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 292 NGIVVDRLakkgydlakTRKTAIVCGLMMSALGTLLVVQSSSPAQAVAFISMALFCVHFAGTSAWGLVQVMVSETKVASI 371
Cdd:cd17325 255 AGKLSDRI---------GRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTA 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1618847556 372 AGIQNFGSFVFASFAPIVTGWVVDTThSFNLALVIAACVTFTGALCYFFIV 422
Cdd:cd17325 326 MGLFNTAFSLGMVLGPLLGGFLYDAF-GFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
21-419 |
1.33e-29 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 118.15 E-value: 1.33e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 21 QTVTLVLLFMAGIVNFLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSL 100
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 101 MQALTGMVNSFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMF 180
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 181 VIIGVAGILVGICWYAWYRNRAQFVLTdeertylsapvkprpqlqfsewlalfkhrttWGMILGFSGVNYTGWLYiaWLP 260
Cdd:cd17312 161 LVPGIVGLVVAIILFFFLRDSPPYVWV-------------------------------LSLAYAFVYIVRYACLD--WGP 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 261 GYLQAEQGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRLakkgyDLAKTRKTAIVCGLMMSALGTLLVVQSSSPAQAVAF 340
Cdd:cd17312 208 LYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKL-----FGGRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVL 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 341 ISMALFCVhFAGTSAWGLVQVMVSETKVA--SIAGIQNFGSFVFASFAPIVTGWVVDTTHSFNLALV-IAACVTFTGALC 417
Cdd:cd17312 283 LFLIGFFV-GGPINLIGGAAAQDIGRKEAagTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFlISAALLSVLLLL 361
|
..
gi 1618847556 418 YF 419
Cdd:cd17312 362 SL 363
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
25-421 |
1.58e-25 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 106.89 E-value: 1.58e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 25 LVLLFMAGIVNFLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQAL 104
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 105 TGMVNSFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIApPALVLMQLAWGWRTMFVIIG 184
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVG-PLLGGLLAAISWRYPFFLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 185 VAGILVGICWyawyrnraqFVLTDEErtylSAPVKPRPQLQFSEWLALFKHRTTWGMILGFSGVNYTGWLYIAWLPGYLQ 264
Cdd:cd17474 160 ALIPVAFLAI---------LFLLPEP----KEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLE 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 265 AEQGFSLAKTGWVAAIPFLAAAVGmwvnGIVVDRLAKKGYDLAKTRKTAIVCglmmsaLGTLLVVQSSSPAQAVAFISMA 344
Cdd:cd17474 227 LLYGISPIIIGLLFAGWSVLLALG----SLFVGRLLKKRFGARRILVIGLLL------YALSLLLLGFVPSLALLLIAIV 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 345 LFCVHFAGTSAwgLVQVMVSETKV----ASIAGIQNFGSFVFASFAPIVTGWVVDtTHSFNLALVIAACVTFTGALCYFF 420
Cdd:cd17474 297 LFGLGLGLNLP--LLTTLVTELAPeeerGTASSLYNFVRFLGQAVGPLLFGLLLE-IFGLSAPFLVGAAIALAAAVLLAL 373
|
.
gi 1618847556 421 I 421
Cdd:cd17474 374 L 374
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
36-395 |
1.33e-24 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 104.63 E-value: 1.33e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 36 FLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGMVNS-FSHF 114
Cdd:cd17345 16 YLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSaTSSV 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 115 ILMRIGL---GIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWG---WRTMFVIIGVAGI 188
Cdd:cd17345 96 GLMFILLflnGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGdgwWRGAFIFPAIIAI 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 189 LVGICWYAWYRNRAQFV-LTDEERTYLSAPVKPRPQLQ---FSEWLALFKH--RTTWGMILGFSGVnytgWLYIA----- 257
Cdd:cd17345 176 IVAVIVLFLGKDTPESEgLPPIEEYKGDYPEEADGEEEeqeLSAWEIFVKYvlKNKLLWYIAIANV----FVYLVrygil 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 258 -WLPGYLQAEQGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRLAKkgydlAKTRKTAIVCglmMSALGTLLVVQSSSPAQ 336
Cdd:cd17345 252 dWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFK-----GRRAPTGIIF---MILVIVALIVYWLAPNV 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1618847556 337 AVAFISMAlfcvhFAGTSAWG---LVQVMVSE----TKVASIAGIQNFGSFVF-ASFAPIVTGWVVD 395
Cdd:cd17345 324 LVDLIALI-----ALGFLIYGpvmLIGLQALElvpkKAAGTAAGLTGLFGYLGgSVLATALIGIIVD 385
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
25-408 |
3.55e-23 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 99.93 E-value: 3.55e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 25 LVLLFMAGIVNFLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQAL 104
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 105 TGMVNSFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVIIG 184
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 185 VAGILVGICWYAWYRNRAQFvltdeertylsapvKPRPQLQFSEWLALFKHRTTWGM----ILGFSGVnYTGWLYIAWlp 260
Cdd:cd17324 161 VLALLAALLLWRLLPSLPPK--------------KPGSLGLLSSLLLLLRNPRLRLAylitFLLFGGF-FALYTYLAP-- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 261 gYLQAEQGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRLAkkgydlaktRKTAIVCGLMMSALGTLLVVqsSSPAQAVAF 340
Cdd:cd17324 224 -FLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGG---------RRALLIALLLLAAALLLLTL--LGPSPLLLL 291
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1618847556 341 ISMALFCVHFAGTSAWGLVQVM-VSETKVASIAGIQNFGSFVFASFAPIVTGWVVDTTHSFNLALVIAA 408
Cdd:cd17324 292 VGLVLWGLGFFAAHSALQTRVLrLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAA 360
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
48-420 |
3.59e-23 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 100.34 E-value: 3.59e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 48 AIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGMVNSFSHFILMRIGLGIGEAP 127
Cdd:cd17320 24 AIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 128 FMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVIIGVAGILVGIcWYAWYRNraqfvlt 207
Cdd:cd17320 104 GSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLL-LVLLFLP------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 208 deeRTYLSAPVKPRPQLQFSEWLALFKHRTTWGMILGFSGVNYTGWLYIAWLPGYLQAEQGFSLAKTGWVAAIPFLAAAV 287
Cdd:cd17320 176 ---ETLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALIL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 288 GMWVNGIVVDRlakkgYDLAKTRKTAIVCgLMMSALGTLLVVQSSSPAQAVAFISMALFCVHFAGTSAWGLVQVMVSETK 367
Cdd:cd17320 253 GSLLNGRLVRR-----FGPRRLLRLGLLL-LLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPH 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1618847556 368 VASIAG-IQNFGSFVFASFAPIVTGWVVDTTHSfNLALVIAACVTFTGALCYFF 420
Cdd:cd17320 327 VAGTASaLLGFLQFLIGALAGALVGLLPNGTAL-PMGLLILVLGLLALLLLILL 379
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
25-416 |
3.86e-23 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 100.04 E-value: 3.86e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 25 LVLLFMAGIVNFLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQAL 104
Cdd:cd17355 5 LAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 105 TGMVNSFSHFILMRIGLGIGEAPFMPAGV-KSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVII 183
Cdd:cd17355 85 LALATSLWQLYLLWGLLGGGGAGTLAAVAfATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 184 GVAGILVGI-CWYAWYRNRAqfvltdeeRTYLSAPVKPRPQLQFSEWLALFKHRTTWGMILGFSGVNYTGWLYIAWLPGY 262
Cdd:cd17355 165 ALLALLVLVpVLLLLRRRPA--------DLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 263 LqAEQGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRLAKKgydlaktRKTAIVCGLMMSALGTLLVVQSSSPAQAVAFIS 342
Cdd:cd17355 237 L-ADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPR-------RLLAASYALRALGLALLLLLPFPPLALLLFAAL 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1618847556 343 MALFCVHFAGTSAwGLVQVMVSETKVASIAGIQNFGSFVFASFAPIVTGWVVDTTHSFNLALVIAACVTFTGAL 416
Cdd:cd17355 309 FGLGWGATVPLTA-ALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAAL 381
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
25-406 |
2.92e-21 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 94.63 E-value: 2.92e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 25 LVLLFMAGIVNFLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSL-MQA 103
Cdd:cd17341 1 LHLSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIpLLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 104 LTGMVNSFSHFILMRIGLGIGEAPFMpAGVKSITDWYAQKERGTALGIF----NSSTVIGQAIAPP---ALVLMQLAWGW 176
Cdd:cd17341 81 LALAVSSYWGLLVLGFLLGFAGANFA-SGQPWASFWFPKEKIGGAAGGIagagNMGVAVSQLLAPLiagAIVFDGGFVGW 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 177 RTMFVIIGVAGILVGICWYAWYRNraqfvltdeertylsAPVKPRPQLQF-SEWLALFKHRTTWGMILGFsGVNYTGWL- 254
Cdd:cd17341 160 RNAFFVPGILLAIAAVLVLLFGDD---------------LPTGKASALEFlKVQLAVLKNYRTWILSLLY-GVTFGSFVg 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 255 YIAWLPGYLQAEQGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRlakkgydLAKTRKTAIVCGLMMSALGTLLVVQSSSP 334
Cdd:cd17341 224 FSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDR-------FGGRRRLWWLFIVMTIGAALLSLSLPTSG 296
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1618847556 335 AQAVAFISMALFCVHFAGtSAWGLVQVMVS-----ETKVAS--IAGIQNFGSFVFasfaPIVTGWVVDTTHSFNLALVI 406
Cdd:cd17341 297 TNLVLFLALFVALGLGAG-AGNGSVFRMVPfifrrELGAVTglVGAIGGLGGFFL----PLLFGSSALMTGSGVGAFSL 370
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
49-419 |
5.46e-21 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 93.77 E-value: 5.46e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 49 IRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGMVNSFSHFILMRIGLGIGEAPF 128
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAF 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 129 MPAGVKSITDwYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVIIGVAGILVGICWYAWYRnraqfvltd 208
Cdd:cd17478 102 HPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRP--------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 209 eertyLSAPVKPRPQLQFSEWLALFKHRTTWGMILGFSGVNYtgWLYIA---WLPGYLqAEQGFSLAKTGWVAAIPFLAA 285
Cdd:cd17478 172 -----LKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRS--WVLSSlttFLPFYL-VQRGYSLVFAGLLLSLFLFAG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 286 AVGMWVNGIVVDRLAkkgydlaktRKTAIVCGLMMSALGTLLVVQSSSPAQAVAFIsMALFCVHFAGTSAWGLVQVMVSE 365
Cdd:cd17478 244 AIGTLIGGPLSDRFG---------RRRVIIASLLLAAPFLLLFLLTPGIWSYILLV-LAGFLLFASFPVTVVLAQELLPG 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1618847556 366 tKVASIAGIQNFGSFVFASFAPIVTGWVVDTThSFNLALVIAACVTFTGALCYF 419
Cdd:cd17478 314 -NVGLASGLMMGLSFGLGGIGAPVLGALADAF-GLESVLLILALLPLLGALLAF 365
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
26-418 |
6.83e-21 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 93.84 E-value: 6.83e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 26 VLLFMAGIVNFLDRSSLSVA----------------------GEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLD 83
Cdd:cd17318 2 ILLFLGFAVVYAMRVNLSVAivamvnstathdnnntstdkdtLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLAE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 84 RFGPRIVLGAGLIFWSLMQALTGMVNSFSH--FILMRIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQA 161
Cdd:cd17318 82 KYGAKRVLGYSILITALLTLLTPLAARGGYgaLIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 162 IAPPALVLMQLAWGWRTMFVIIGVAGILVGICWYawyrnraqfvltdeertYLSAPVkprpqlqfsewlalfkhrttWGM 241
Cdd:cd17318 162 IAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWF-----------------FLVLPV--------------------WAI 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 242 ILGFSGVNYTGWLYIAWLPGYLQAEQGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRLAKKG-YDLAKTRKTAIVCGLMM 320
Cdd:cd17318 205 VVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGiLSTTTVRKLFTSIGFLG 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 321 SALGTLLVVQ-SSSPAQAVAFISMALFCvHFAGTSAWGLVQVMVSETKVASIAGIQNFGSFVFASFAPIVTGWVV---DT 396
Cdd:cd17318 285 PGVFLIALGYlGSNATLAVVFLTLSVGL-SGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPLIVGAIVkndQT 363
|
410 420
....*....|....*....|..
gi 1618847556 397 THSFNLALVIAACVTFTGALCY 418
Cdd:cd17318 364 IGQWRIVFFISAAIYILGAIFY 385
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
14-425 |
2.85e-20 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 91.84 E-value: 2.85e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 14 PQRIRRIQTVTLVLLFMAGIVNfldrSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGA 93
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFAT----ALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 94 GLIFWSLMQALTGMVNSFSHFILMRIGLGIGEAPFMPAGVKSITDWYaQKERGTALGIFNSSTVIGQAIAP---PALVLM 170
Cdd:COG0738 79 GLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALG-PETAASRLNLLHAFFSLGALLGPllgGLLILL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 171 QLAWGWRTMFVIIGVAGILVGICWYawyrnRAQFVLTDEERTYLSAPVKPRpqlqfsewLALFKHRTTWGMILGFSGVNY 250
Cdd:COG0738 158 GLSLSWHLPYLILAVLLLLLALLFL-----RSKLPEIEEEEEEAAGSAASL--------KSLLKNPRLLLGGLAIFLYVG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 251 TGWLYIAWLPGYLQAEQGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRLAkkgydlaktRKTAIVCGLMMSALGTLLVVQ 330
Cdd:COG0738 225 AEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFG---------PVRLLRLSALLAAVGLLLALL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 331 SSSPAQAVAFISMALFCVHFAGTSAWGLVQVMVSETKVASIAGIQNFGSFVFAsFAPIVTGWVVDTThSFNLALVIAACV 410
Cdd:COG0738 296 APGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGA-IGPPLIGFLADAF-GLRAAFLVPLVC 373
|
410
....*....|....*
gi 1618847556 411 TFTGALCYFFIVKDR 425
Cdd:COG0738 374 YLLILLLALALKRKR 388
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
56-420 |
1.09e-19 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 89.94 E-value: 1.09e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 56 SATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGMVNSFSHFILMRIGLGIGEAPFMPAGVKS 135
Cdd:cd17473 33 SELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATAL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 136 ITDWYAQKERGTALGIFNSSTVIGQAIApPALVLMQLAWGWRTMFVIIGVAgILVGICWYAWYRNRAQfvltDEERTYLS 215
Cdd:cd17473 113 IGDYFEGEERAKMLGLQSAAMSLGGVVF-LLLGGALAEIGWRAPFLVYLLA-LPVLILVLLFLPEPAR----KSKSAASP 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 216 APVKPRPQLQFSEWLALFkhRTTWGMILGFSGVNYtgwlyiawLPGYLQAEQGFSLAKTGWVAAIPFLAAAVGmwvnGIV 295
Cdd:cd17473 187 GAATAAALPWKRVLPIYF--LAFLAMLLFYVIPIQ--------LPFLLQERGGGSAALIGLALAIASLAGAIG----ALL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 296 VDRLAKKgydlaKTRKTAIVCGLMMSALGTLLVVQSSSPAQAVAFISMALFCVHFAGTSAWGLVQVMVSETKVASIAGIQ 375
Cdd:cd17473 253 FGRLKRR-----LGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIV 327
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1618847556 376 NFGSFVFASFAPIVTGWVVDTTHSFNLALVIAACVTFTGALCYFF 420
Cdd:cd17473 328 TSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLL 372
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
25-419 |
3.69e-19 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 88.04 E-value: 3.69e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 25 LVLLFMAGIVNFLDRSSLSVAGEAIRGE--LGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQ 102
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEfsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 103 ALTGMVNSFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAppALV------LMQLAWGW 176
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLA--ALVasllipLLSGDWGW 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 177 RTMFVIIGVAGILvgicwyawyrnraqfvltdeertylsapvkprpqlqfsewlALFKHRTTWGMILGFSGVNYTGWLYI 256
Cdd:cd17316 159 RILFLIGALPALL-----------------------------------------ALLLRRRTLLLILLWFFISFGYYGLT 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 257 AWLPGYLQAEQGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRLAkkgydlaktRKTAIVCGLMMSALGTLLVVQSSSPAQ 336
Cdd:cd17316 198 TFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIG---------RKKTLVIGLILSGILALPLFYLLSGSP 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 337 AVAFIsmALFCVHFAGTSAWGLVQVMVSE---TKV-ASIAGIQNFGSFVFASFAPIVTGWVVDTTHSFNLALVIAACVTF 412
Cdd:cd17316 269 TLLLL--LLFILSFFVGGVWGALYAYLAElfpTEVrATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAI 346
|
....*..
gi 1618847556 413 TGALCYF 419
Cdd:cd17316 347 VALIVAL 353
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
19-300 |
5.39e-19 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 86.79 E-value: 5.39e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 19 RIQTVTLVLLFMAGIVNFLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFW 98
Cdd:COG0477 10 RRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 99 SLMQALTGMVNSFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRT 178
Cdd:COG0477 90 GLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRW 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 179 MFVIIGVAGILVGICWYAWYRNRAQFVLtdEERTYLSAPVKPRPQLQFSEWLALFKHRTTWGMILGFSGVNYTGWLYIAW 258
Cdd:COG0477 170 IFLINAPLGLLALVLRLRLPESRGLLLA--LLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLL 247
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1618847556 259 LPGYLQAEQGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRLA 300
Cdd:COG0477 248 LALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLL 289
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
28-194 |
3.58e-18 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 85.54 E-value: 3.58e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 28 LFMAGIVNFLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGM 107
Cdd:cd17488 8 MFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 108 VNSFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVIIGVAG 187
Cdd:cd17488 88 SSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGMYVPGIIA 167
|
....*....
gi 1618847556 188 ILVGI--CW 194
Cdd:cd17488 168 ILMGIvlCW 176
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
36-194 |
1.09e-17 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 84.76 E-value: 1.09e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 36 FLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIfwslmqaLTGMVN---SFS 112
Cdd:PRK11663 36 YFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLI-------ATGIINilfGFS 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 113 HFILMRIGLGIGEAPFM----PAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVIIGVAGI 188
Cdd:PRK11663 109 SSLWAFALLWVLNAFFQgwgwPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIALHYGWRYGMMIAGIIAI 188
|
....*...
gi 1618847556 189 LVGI--CW 194
Cdd:PRK11663 189 VVGLflCW 196
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
28-421 |
1.65e-17 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 83.38 E-value: 1.65e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 28 LFMAGIVNFLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGM 107
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 108 VNSFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVIIGVAG 187
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 188 ILVgicwyawyrnraqFVLTdeertylsapvkprpqlqfsewlalfkhRTTWGMILGFSGVNYTGWLYIAWLPGYLQAEQ 267
Cdd:cd17321 161 LVA-------------LLLA----------------------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVL 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 268 GFSLAKTGWVaaipFLAAAVGMWVNGIVVDRLAKKgydlaKTRKTAIVCGLMMSALGTLL---VVQSSSPAQAVAFISMA 344
Cdd:cd17321 200 GYSPLQAGLA----LLPLALAMLVAAPLAGRLADR-----FGPRLVLVAGLLLTAVGLLLlalLGADSSVWLLLPGLVLL 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 345 LFCVHFAGTSAWGLVQVMVSETKVASIAGIQN-------------FGSFVFASFAPIVTGWVVDT---------THSFNL 402
Cdd:cd17321 271 GLGLGLFATPLTNAALSSVPKEKAGAASGILNtarqlggalgvalLGALLTAGLSANLGDSGVAAllsaaaaafAAGFHL 350
|
410
....*....|....*....
gi 1618847556 403 ALVIAACVTFTGALCYFFI 421
Cdd:cd17321 351 AFLVAAALALLAALLALLL 369
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
61-197 |
1.51e-15 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 73.07 E-value: 1.51e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 61 GVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGMVNSFSHFILMRIGLGIGEAPFMPAGVKSITDWY 140
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1618847556 141 AQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVIIGVAGILVGICWYAW 197
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFL 137
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
14-394 |
2.04e-15 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 77.40 E-value: 2.04e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 14 PQRIRRIQTVTLVLLFMAGIVNFLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGA 93
Cdd:TIGR00895 8 KQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLW 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 94 GLIFWSLMQALTGMVNSFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLA 173
Cdd:TIGR00895 88 SILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 174 WGWRTMFVIIGVAGILVGICWYAWYRNRAQFVLTDEERTYLSAPVKPRPQLQF-----------------SEWLALFKHR 236
Cdd:TIGR00895 168 FGWRSLFYVGGIAPLLLLLLLMRFLPESIDFLVSKRPETVRRIVNAIAPQMQAeaqsalpeqkstqgtkrSVFKALFQGK 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 237 T---TWGMILGFSGVNYTGWLYIAWLPgYLQAEQGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRLakkgydlaktRKTA 313
Cdd:TIGR00895 248 TariTVLLWLLYFMLLVGVYFLTNWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRL----------GPRV 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 314 IVCGLMMSALGTLLVVQS-SSPAQAVAFISMALFCVHFAGTSAWGLVQVMVSE----TKVASIAGIQNFGSFvfasFAPI 388
Cdd:TIGR00895 317 TALLLLLGAVFAVLVGSTlFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTairaTGVGWAIGIGRLGAI----IGPI 392
|
....*.
gi 1618847556 389 VTGWVV 394
Cdd:TIGR00895 393 LAGYLL 398
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
25-327 |
2.16e-15 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 77.23 E-value: 2.16e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 25 LVLLFMAGivnfLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQAL 104
Cdd:cd17503 2 LLGAFMAI----LDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 105 TGMVNSFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVIIG 184
Cdd:cd17503 78 CGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 185 VAGILVgicwyawyrnraqfvltdeertYLSAPVKPrpqlqfsewLALFKHRT-TWGMILGF-SGVNYTGWLYIawLPGY 262
Cdd:cd17503 158 PIGILA----------------------LLLAPLLD---------LRLFKDRNfTLGLLLSFlLGLGLFGAMFL--LPLY 204
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1618847556 263 LQAEQGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRLakkGYdlaktrKTAIVCGLMMSALGTLL 327
Cdd:cd17503 205 LQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKF---GP------RLLLLAGLLLLALGTLL 260
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
48-352 |
2.59e-15 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 76.57 E-value: 2.59e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 48 AIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGMVN-SFSHFILMRIGLGIGEA 126
Cdd:TIGR00886 27 LIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVqSYSVLLLIRLFIGIAGG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 127 PFMPAgVKSITDWYAQKERGTALGIF----NSSTVIGQAIAPPALVLM--------QLAWGWRTMFV---IIGVAGILVG 191
Cdd:TIGR00886 107 SFASC-MPWISFFFPKKIQGTALGLAagwgNMGGGVAQFVMPPIIGSLifgggqpaHLAWGWAFVIVpagILLLPALLIF 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 192 ICWYAWYRNRaqfvltdeertylSAPVKprpqLQFSEWLALFKHRTTWGMILGFSgVNYTGWL-YIAWLPGYLQAEQGFS 270
Cdd:TIGR00886 186 FVGADTPPGK-------------PATGK----LSFKEALKVFGNRHTWILALLYS-VTFGSFLgVSSIFAMLFKDQFGLS 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 271 LAKTGWVAAIPFLAAAVGMWVNGIVVDRlakkgydLAKTRKTA-IVCGLMMSALgtLLVVQSSSPAQAVAFISMALFCVH 349
Cdd:TIGR00886 248 KVQAGAYASLGGFLGSLARPAGGAISDR-------LGGARKLLmNFLGVAMGAF--LVVLGLVSDGSLAAFIVLFVALFF 318
|
...
gi 1618847556 350 FAG 352
Cdd:TIGR00886 319 FAG 321
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
21-302 |
5.65e-14 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 73.14 E-value: 5.65e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 21 QTVTLVLLFMAGIVNFLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSL 100
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 101 MQALTGMVNSFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMF 180
Cdd:cd17343 81 TTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 181 VIIGVAGILVGICWYAWYRNRAQFVLTDEERTYLSAPVKPRPQLQFSEWLALFKHRTTWGMILGFSGVNYTGWLYIAWLP 260
Cdd:cd17343 161 SISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEESKGKKKKSPRGESTLKELLLSPFLWLLSLGYLVVFGVKTAVTDWGQ 240
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1618847556 261 GYLQAEQGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRLAKK 302
Cdd:cd17343 241 LFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAK 282
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
22-340 |
2.26e-13 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 71.15 E-value: 2.26e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 22 TVTLVLLFMAGIVNFLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLM 101
Cdd:PRK11551 14 ALTIGLCFLVALLEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLF 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 102 QALTGMVNSFSHFILMRI--GLGIGEApfMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTM 179
Cdd:PRK11551 94 SLATAQAWDFPSLLVARLltGVGLGGA--LPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHI 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 180 FVIIGVAGILVGICWYAWYRNRAQFVltdeERTYLSAPVKPRPQLQFSEWLAlfkhRTTWGMILGFSGVNYTGWLYIAWL 259
Cdd:PRK11551 172 FYVGGVGPLLLVPLLMRWLPESRAFA----QAAGAGKQRAPVLRALFGEGRA----TATLLLWISYFFTLIVLYFLLNWL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 260 PGyLQAEQGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRlakkgydLAKTRKTAIVCGLMMSALGTLLVVQSSSPAQAVA 339
Cdd:PRK11551 244 PS-LLVGQGLSRSQAGLVQIAFNIGGALGSLLIGALMDR-------LRPRRVVLLIYAGILASLAALAAAPSFAGMLLAG 315
|
.
gi 1618847556 340 F 340
Cdd:PRK11551 316 F 316
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
52-422 |
3.34e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 70.32 E-value: 3.34e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 52 ELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGMVNSFSHFILMRIGLGIGEAPFMPA 131
Cdd:cd17489 25 DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 132 GVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVIIGVAGIL-VGICWYAWYRNraqfvltdee 210
Cdd:cd17489 105 AATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLaLLLVFLVKDPP---------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 211 rtylsAPVKPRPQLQFSEWLALF-KHRTTWGMILGFSGVNYTGwlYIAWLPGYLqAEQGFSlaktgwVAAIPFLAAAVGM 289
Cdd:cd17489 175 -----PVAAEEAEAGTRAFRRLVeKKVLPPALILFLASIAYGA--ISTFLPLYA-AERGIS------NAGLFFTVYAIAL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 290 WVNGIVVDRLAKKgydlaKTRKTAIVCGLMMSALGTLLVVQSSSPaqAVAFISMALFCVHFAgtSAWGLVQVMVSETKVA 369
Cdd:cd17489 241 LLSRPFSGKLSDR-----KGPKTVIIPGLLLLALGLLLLSFAGSP--WMLLLAAVLYGLGFG--LLFPALQALAVDLVPP 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1618847556 370 SIAGIQNFGSFVFA----SFAPIVTGWVVDTThSFNLALVIAACVTFTGALCYFFIV 422
Cdd:cd17489 312 HRRGAANGTFFIFFdlgiGLGGLLLGLVAELF-GYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
48-421 |
8.61e-13 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 69.25 E-value: 8.61e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 48 AIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGMVNSFSHFILMRIGLGIGEAP 127
Cdd:cd17371 24 ALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 128 FMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAP-PALVLMQLA---WGWRTMFViigVAGILVGICWY--AWYRNR 201
Cdd:cd17371 104 EWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATlLAALLFPLLppeIAWRVLFL---LGALPALLVLFirRFVKEP 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 202 AQFVLTDEERTYLSAPVKPRpqLQFSEWLAlfkhRTTWGMILGFSGVNYTGWLYIAWLPGYLQAEQGFSLAKTGWVAAIP 281
Cdd:cd17371 181 PQWQAARAARRHFADRPSLR--ELFSPPLL----RTTLLASLLATGALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVT 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 282 FLAAAVGMWVNGIVVDRLAkkgydlaktRKTAIVCGLMMSALGTLLVVQ-SSSPAQAVAFISMALFCVhFAGTSAWG--L 358
Cdd:cd17371 255 ILGGFLGYLAGGFLADRIG---------RRNNFALFALGSAISILLYFFlPLSPTLILILGFPLGFFA-SGPFSGMGayL 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1618847556 359 VQVMVSETKVASIAGIQNFGSFVfASFAPIVTGWVVDTTHSFNLALVIAACVTFTGALCYFFI 421
Cdd:cd17371 325 TELFPTAVRATAQGFCYNVGRII-GALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLL 386
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
40-412 |
1.11e-12 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 68.76 E-value: 1.11e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 40 SSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGMVNSFSHFI---L 116
Cdd:cd17339 16 TSVGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLRSLGGIALLFLgtaL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 117 MRIGLGIGEApFMPAGVKSitdwYAQKERGTALGIFNSSTVIGQAIAPPALVLMQ--LAWGWRTMFVIIGVAGILVGICW 194
Cdd:cd17339 96 AGAGIAVGNV-LLPSLIKR----DFPRRVGLMTGLYTTSMNLGAALASGLSVPLAqaLGGGWRGALAIWALPALLALLIW 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 195 -YAWYRNRAqfvltdeertylsAPVKPRPQLQFSEWlalfKHRTTWGMILGF---SGVNYTGwlyIAWLPGYLQaEQGFS 270
Cdd:cd17339 171 lPQLRRRKR-------------AAAAAAPLTKISVW----RSPLAWQVTLFMglqSLLFYTL---MAWLPTILI-DAGLS 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 271 LAKTGWVAAIPFLAAAVGmwvnGIVVDRLAKKGYDLaktRKTAIVCGLMMSA-LGTLLVVQSSSPAQAVAFISmalfcvh 349
Cdd:cd17339 230 AATAGWLLSLFQLVGIPA----SLLVPILATRLKNQ---RPIVVLLAVLFIIgVLGLLFAPTALALLWAVLLG------- 295
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1618847556 350 FAGTSAWGLVQVMVS-----ETKVASIAGIQNFGSFVFASFAPIVTGWVVDTTHSFNLALVIAACVTF 412
Cdd:cd17339 296 LGGGAAFSLALTLISlrssdPAEAAALSGMAQSVGYLLAALGPLLFGVLHDLTGSWTAPLVLLLALTV 363
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
52-203 |
1.62e-12 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 68.97 E-value: 1.62e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 52 ELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGMVN-SFSHFILMRIGLGI-GEAPFM 129
Cdd:PRK11273 57 EQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPwATSSIAVMFVLLFLcGWFQGM 136
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1618847556 130 --PAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPaLVLMQLAW--GWRTMFVIIGVAGILVGICWYAWYRNRAQ 203
Cdd:PRK11273 137 gwPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGLPPL-LFLLGMAWfnDWHAALYMPAFAAILVALFAFAMMRDTPQ 213
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
61-418 |
5.97e-12 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 67.08 E-value: 5.97e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 61 GVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALT--GMVNSFSHFILMRIGLGIGEAPFMPAGVKSITD 138
Cdd:TIGR00894 79 GLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIpwAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVK 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 139 WYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAW-GWRTMFVIIGVAGILVGICWYAWYRN--RAQFVLTDEERTYLS 215
Cdd:TIGR00894 159 WAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWgGWPMIFYVFGIVGCAWSLLWFVFPADdpSIHPCISKFEKKYIN 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 216 APVKPR--PQLQFSEWLALFKHRTTWGMILGFSGVNYTGWLYIAWLPGYLQAEQGFSLAKTGWVAAIPFLAAavgmWVNG 293
Cdd:TIGR00894 239 SSLQGQkgSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFA----WLCS 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 294 IVVDRLA---KKGYDLAKTRKTAIVCGLMMSALGTLLVVQSSSPAQAVAFISMALFCVHFAGTSAWGLVQVMVSETKVAS 370
Cdd:TIGR00894 315 IFAGYLAdflKSSKTLSLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPRFL 394
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1618847556 371 --IAGIQNFGSFVFASFAPIVTGWVV--DTTHSFNLALVIAACVTFTGALCY 418
Cdd:TIGR00894 395 gfIKGITGLPGFIGGLIASTLAGNILsqDSKNVWLIVFLIMAFVNILCVIFY 446
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
28-421 |
1.11e-11 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 65.68 E-value: 1.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 28 LFMAGIVNFLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGM 107
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 108 VNSFSHFILMRIGLGIGEAPFmPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVIIGVAG 187
Cdd:cd17504 81 APNLPVLIAGRALQGIGGAVF-PLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 188 ILVGICwyawyrnraqfvltdeertylsAPVKPrpqlqfsewLALFKHRTTWGMILGFSGVNYTGWLYIAWLPGYLQAEQ 267
Cdd:cd17504 160 VLLAAL----------------------VPLID---------LRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPT 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 268 GFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRLAKK-GYdlaktrKTAIVCGLMMSALGTL-LVVQSSSPAQAVAFISMAL 345
Cdd:cd17504 209 PTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARvGP------RRVLLIGLVISAVGLLlLALLHSSLWALVVALLLIG 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 346 FCVHFAGTSAWGLVQVMVSETKVASIAG----IQNFGS--------FVFASFAPIVTGWVVDTTHSFNLALVIAACVTFT 413
Cdd:cd17504 283 IGLGLAFASLPNIVVESVPPDRTGIATGmntvLRTIGSaigpaiagAILTTYTVSITSGGVPTEGAYVLAFLIGAALALA 362
|
....*...
gi 1618847556 414 GALCYFFI 421
Cdd:cd17504 363 ALLLSLLI 370
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
52-421 |
1.18e-11 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 65.65 E-value: 1.18e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 52 ELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGMVNSFSHFIL-MRIGLGIGEAPFMP 130
Cdd:cd17352 32 EFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLtYGVLGGLGLGLIYS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 131 AGVKSITDWYaQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVIIGVAGILVGICWYAwyrnraqfvltdee 210
Cdd:cd17352 112 PAIVIVGQYF-EKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVCGLL-------------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 211 rtylsapvkprpqlqfsewLALFKHRTTWGMILGFSGVNYTGWLYIAWLPGYLqAEQGFSLAKTGWVAAIPFLAAAVGMW 290
Cdd:cd17352 177 -------------------LRLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYA-KSLGIDESDAAFLLSIIGISDIVGRI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 291 VNGIVVDRLAKKgydlaktRKTAIVCGLMMSALGTLLVVQSSSPAQAVAFISMALFCVHFAGTSAWGLVQVMVSETKVAS 370
Cdd:cd17352 237 LLGLLADKPRIG-------RLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSN 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1618847556 371 IAGIQNFGSFVFASFAPIVTGWVVDTTHSFNLALVIAACVTFTGALCYFFI 421
Cdd:cd17352 310 AYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLL 360
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
52-420 |
2.83e-11 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 64.56 E-value: 2.83e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 52 ELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGMVNSFSHFILMRIGLGIGEAPFMPA 131
Cdd:cd17329 29 QLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 132 GVKSITDWYAQKERGTALGIFNSSTVIGQAIApPALVLMQLAWGWRTMFVIIGVAGILVGICWYAWYRNRAqfvltdeer 211
Cdd:cd17329 109 SEAMIADVTTPENRTRAFSLLYWAINLGVAIG-PLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETR--------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 212 tylSAPVKPRPQLQFSEWLALFKHRTTWGMILGFSGvnyTGWLYIAW---LPGYLQAEQGFSLAKTGWVAAIPFLAAAVG 288
Cdd:cd17329 179 ---PKRRAAEKTEILRGYKIVLRDRAFLLFLLASFL---ISLIYFQLestLPVYVVEILGLGESLLGLLLALNALLIVLL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 289 MwvngIVVDRLAKKgydlaKTRKTAIVCGLMMSALGTLLVVQSSSPaqAVAFISMALFCVhfAGTSAWGLVQVMVS---- 364
Cdd:cd17329 253 Q----FPVARLVER-----FRLRKILMIGILLFAIGFAVLAFANTL--AVLILAMIVLTL--GEMLVFPAVQTLVAalap 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1618847556 365 ETKVASIAGIQNFGSFVFASFAPIVTGWVVDTTHSFNLALVIAACVTFTGALCYFF 420
Cdd:cd17329 320 PDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
61-422 |
4.44e-11 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 64.03 E-value: 4.44e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 61 GVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGMVNSF--SHFILMRIGLGIGEAPFMPAGVKSITD 138
Cdd:cd17381 68 GWILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLgaGYLIAVRALEGLGEGVTFPAMHAMWAS 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 139 WYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVIIGVAGILVGICWYawyrnraqfvltdeertylsapv 218
Cdd:cd17381 148 WAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWI----------------------- 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 219 kprpqlqfseWLALfkhrTTWGMILGFSGVNYTGWLYIAWLPGYLQAEQGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDR 298
Cdd:cd17381 205 ----------WLVM----PLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADN 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 299 L-AKKGYDLAKTRKTAIVCGLMMSALGTLLVVQSS-SPAQAVAFISMALFCVHFAgTSAWGLVQVMVSETKVASIAGIQN 376
Cdd:cd17381 271 LrEKQNFSTVCVRKIFTLIGMIGPAVFLLAAGFTGcNYSLAVAFLTISSTLGGFS-ASGFNINHLDIAPSYAGILLGITN 349
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1618847556 377 FGSFVFASFAPIVTGWVV--DTTHSFNLALVIAACVTFTGALcyFFIV 422
Cdd:cd17381 350 TFATIPGMVGPVIAKSLThnNTVEEWQTVFYISAAINVFGAI--FFTI 395
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
25-194 |
6.12e-11 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 63.75 E-value: 6.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 25 LVLLFMAGIVNFLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQAL 104
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 105 TGMVNSFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFviiG 184
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIF---W 157
|
170
....*....|
gi 1618847556 185 VAGILVGICW 194
Cdd:cd17323 158 FLAIISGFCL 167
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
52-421 |
7.20e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 63.77 E-value: 7.20e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 52 ELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRI-----VLGAGLIFWSLMQALTGMVNSFSH----------FIL 116
Cdd:COG2211 40 VLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpWILIGAIPLALSFVLLFTAPDLSPtgkliyalvtYLL 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 117 MRIGLGIGEAPFMPAGVkSITDWYAQKERGTALGIF--NSSTVIGQAIAPPALVLM--QLAWGWRTMFVIIGVAGILVGI 192
Cdd:COG2211 120 LGLAYTLVNIPYSALGA-ELTPDYEERTRLSSWRFAfaGLGGLLASVLPPPLVAAFggDAALGYRLTALIFAVLGLLAFL 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 193 CWYAWYRNRaqfVLTDEERTYLsapvkprpqlqFSEWLALFKHRTTWGMILGFSGVNYTGWLYIAWLPGYLQAEQGFSLA 272
Cdd:COG2211 199 LTFFGTKER---PVPEEEKVSL-----------KESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAA 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 273 KTGWVAAIPFLAAAVGMWVNGIVVDRLAKkgydlaktrKTAIVCGLMMSALGTLLVVQSSSPAQAVAFISMALFCvhFAG 352
Cdd:COG2211 265 LVGLLLALYFLAALLGAPLWPRLAKRFGK---------KKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAG--IGL 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 353 TSAWGLVQVMVSET-----------KVASIAGIQNFGSFVFASFAPIVTGWVVDTTHsFNLALVIAACVTFTGALCYFFI 421
Cdd:COG2211 334 GAILVLPWAMLADVvdydewktgrrREGLYFGIFTFAIKLGQALAGALAGLLLALFG-YVAGAAQSPSALTGIRLLFFLL 412
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
52-420 |
1.03e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 63.02 E-value: 1.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 52 ELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVL-----GAGLIFWSLMQALTGMVNSFSHFILMRIGLGIGEA 126
Cdd:cd06173 28 QLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLiladlLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 127 PFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVIIGVAGILVGICWYAWYRNRAQfvl 206
Cdd:cd06173 108 FFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPA--- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 207 tdeertyLSAPVKPRPQLQFSEWLALFKHRTTWGMILGFSGVNYT-GWLYIAWLPGYLQAEQGFSLAKTGWVAAipflAA 285
Cdd:cd06173 185 -------APGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALlGGALTVLLPLLAKEVLGGGAAGYGLLLA----AF 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 286 AVGMWVNGIVVDRLAKKgydlaKTRKTAIVCGLMMSALGTLLVVQSSSPAQAVAFISMALFCVHFAGTSAWGLVQVMVSE 365
Cdd:cd06173 254 GVGALLGALLLGRLSKR-----RRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPD 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1618847556 366 TKVASIAGIQNFGSFVFASFAPIVTGWVVDTTHSFNLALVIAACVTFTGALCYFF 420
Cdd:cd06173 329 ELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
60-320 |
1.08e-10 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 63.10 E-value: 1.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 60 FGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGM-----VNSFSHFILMRIGLGIGEAPFMPAGVK 134
Cdd:cd17344 64 LGALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGLgyywnIHSLWYFVVVQILAGLFQSTGWPSVVA 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 135 SITDWYAQKERGTALGIFNSSTVIGQAIAPP-ALVLMQLAWGWRTMF--VIIGVAGILVgicwyawyrnraqfvltdeer 211
Cdd:cd17344 144 CVGNWFGKGKRGLIMGIWNSHTSVGNILGSLiAGIFVSSAWGLSFIVpgIIIAAMGVLV--------------------- 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 212 tYLSAPVKPRPQLQFSewLALFkhrttwgmilgFSG-VNYTgWLYiaWLPGYLQAEQGFSLAKTGWVAAIPFLAAAVGMW 290
Cdd:cd17344 203 -FLFLVEHPPGVIEFS--LCLF-----------FAKlVSYT-FLY--WLPLYISNTAILSAKKAGDLSTLFDVGGIVGGI 265
|
250 260 270
....*....|....*....|....*....|
gi 1618847556 291 VNGIVVDRlakkgydlakTRKTAIVCGLMM 320
Cdd:cd17344 266 LAGYISDY----------TGGRATTCAAML 285
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
28-419 |
2.33e-10 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 61.83 E-value: 2.33e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 28 LFMAGIVNFLDRSSLSVAG---EAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQAL 104
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGfvaPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 105 TGMVNSFSHFILMRI--GLGIGEApfMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVI 182
Cdd:cd17365 81 TAFAQSVLQLALLRFltGLGLGAA--MPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 183 IGVAGILVGICWyawyrnraqfvltdeertylsapvkpRPQLQFseWLALFkhrttWGMILGFsgvnytgwLYIAWLPgY 262
Cdd:cd17365 159 GGVPPLILLPLL--------------------------RGTLLL--WVTFF-----MGLLLVY--------LLNSWLP-K 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 263 LQAEQGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRLAkkgydlaktRKTAIVCGLMMSALGTLLV-VQSSSPAQAVAFI 341
Cdd:cd17365 197 LMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFG---------PKRVLALFFALGAVSLALLgVSPASLVLLYVLV 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 342 SMALFCVHFAGTSAWGLV----QVMVSETKVASIAGIQNFGSFVfasfAPIVTGWVVDTTHSFNLALVIAACVTFTGALC 417
Cdd:cd17365 268 FLAGACVNGAQVGLYALAarfyPTEVRATGVGWALGVGRLGAIL----GPLLGGLLLAAGLGPESVFLALAIPAALGALA 343
|
..
gi 1618847556 418 YF 419
Cdd:cd17365 344 VL 345
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
48-416 |
4.25e-10 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 61.17 E-value: 4.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 48 AIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGMVNSFSHFILMRIGLGIGEAP 127
Cdd:cd06180 24 LMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAF 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 128 FMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAI-APPALVLMQLAWGWRTMFVIIGVAGILVGICWYAWYRNRAQFVL 206
Cdd:cd06180 104 VFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALsGLLVPAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPSAPT 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 207 TdeertylSAPVKPRPQLQFSEWLAlfkhrttwGMILGFSGVNYTgwLYIAWLPGYLqAEQGFSLAKTGWVAAIPFLAAA 286
Cdd:cd06180 184 E-------ASAAESAPGLNRPLWRL--------ALAYGLFGFGYI--ITATFLPLIA-RETGAGSLLAGLLWSLFGLAAV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 287 VGMWVNGIVVDRLAkkgydlaktRKTAIVCGLMMSALGTLLVVQSSSPAQAVafISMALFCVHFAGTSAWglvqVMVSET 366
Cdd:cd06180 246 PSCFLWGALSDRWG---------TRRALAANLLVQAVGVLLPLLSPGPAGLV--LSAVLFGGTFMAITAL----VMALAR 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1618847556 367 KVASIAGIQNFGSFVfASFA------PIVTGWVVDTTHSFNLALVIAACVTFTGAL 416
Cdd:cd06180 311 ELAPPAAPRALALMT-ASFGvgqilgPLLAGWLADATGGFAPALILAAAALVVAAL 365
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
59-420 |
1.07e-09 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 59.66 E-value: 1.07e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 59 EFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQAL--TGMVNSFSHFILMRIGLGIGEAPFMPAGVKSI 136
Cdd:cd17382 50 TVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTSTLNMLipIAARVHYGCVIFVRILQGLVEGVTYPACHGIW 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 137 TDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVIIGVagilVGICWYA-WYrnraqfvltdeertYLS 215
Cdd:cd17382 130 RKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGV----FGIIWYMfWM--------------LVS 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 216 APVkprpqlqfsewlalfkhrttWGMILGFSGVNYTGWLYIAWLPGYLQAEQGFSLAKTGWVAAIPFLAAAVGMWVNGIV 295
Cdd:cd17382 192 MPV--------------------YAIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 296 VDRLAKKGYdLAKT--RKTAIVCGLMMSALGTLLVVQSSSPAQAVAFISMAlfcVHFAGTSAWGL-VQVMVSETKVASI- 371
Cdd:cd17382 252 ADYLRSRGI-LSTTavRKIFNCGGFGMEATFLLVVAFSHSPTVAISFLVLA---VGFSGFAISGFnVNHLDIAPRYASIl 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1618847556 372 AGIQNFGSFVFASFAPIVTGWVV--DTTHSFNLALVIAACVTFTGALCYFF 420
Cdd:cd17382 328 MGISNGIGTLSGMVCPVIVGALTkhKTREEWQYVFLIASLVHFFGVIFYAI 378
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
43-421 |
5.20e-09 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 57.62 E-value: 5.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 43 SVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGMVNSFSHF-----ILM 117
Cdd:cd17353 23 SVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLflgygVLG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 118 RIGLGIGEAPFMPAGVKsitdWYAQKeRGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVIIGV-AGILVGICWYa 196
Cdd:cd17353 103 GIGAGIGYITPVSTAVK----WFPDK-RGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIiFLIIIVIGAF- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 197 WYRNRAQFVLTDEERTYLSAPVKPRPQLQFSEwlaLFKHRTTWGMILGFSGVNYTGWLYIAWLPGYLQAEQGFSLAKTGW 276
Cdd:cd17353 177 LIRDPPKGWVPPGVDPLANNAENSPRDYTPRE---MLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAAL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 277 VAAIPFLAAAVGMWVNGIVVDRLAkkgydlaktRKTAIVCGLMMSALGTLLVVqsSSPAQAVAFISMAlFCVHFAGTSAW 356
Cdd:cd17353 254 AVSILSIFNGGGRPFWGWLSDKIG---------RKNTLSIAFLIQGVAMFLLP--FIGSVAVLFVLGV-ALIGFCYGGGF 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1618847556 357 GLVQVMVSE---TKVASiagiQNFG----SFVFASFAPIVTGWVVDTTHSFNLALVIAACVTFTGALCYFFI 421
Cdd:cd17353 322 ALFPALTADffgTKNAG----TNYGllytAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
23-163 |
6.11e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 57.29 E-value: 6.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 23 VTLVLLFMAGIVNFLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQ 102
Cdd:COG2814 208 RLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGL 287
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1618847556 103 ALTGMVNSFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIA 163
Cdd:COG2814 288 LLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
36-192 |
7.05e-08 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 54.28 E-value: 7.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 36 FLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLD-----RFGPRIVLGAGLIFWSLMQALTGMVNS 110
Cdd:PRK09556 42 YLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADgkntkQFLPFLLILSAICMLGFGASLGSGSVS 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 111 FSHFILMRIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIApPALVLmqlaWGWRT--------MFVI 182
Cdd:PRK09556 122 LGLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGAGA-GGVAL----WGANYffdghvigMFIF 196
|
170
....*....|
gi 1618847556 183 IGVAGILVGI 192
Cdd:PRK09556 197 PSIIALIIGF 206
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
28-415 |
1.49e-07 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 53.18 E-value: 1.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 28 LFMAGIVNFldRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGM 107
Cdd:cd17314 10 LLSAMSTGF--ILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSY 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 108 V-NSFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQKeRGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVIIGVA 186
Cdd:cd17314 88 VfNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDT-KGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGIL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 187 GILVgicwyawyrnrAQFVLTDEERTYLSAPVKPRPQLQFSEWL-ALFKHRTTWGMILGFSGVNYTGWLYIAWLPGYLQA 265
Cdd:cd17314 167 AAIV-----------LSVVSLLGFKEPPDNQARLHVQKKKTQTMgEIFRDKVFWILFIAIFLVLIGGFLFIANMASLVRS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 266 EQGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRLAKKGYDLAktrktaIVCGLMMSALGTLLVVQSSSPAQAVAFISMAL 345
Cdd:cd17314 236 LQLDAPSFVTKLMSIYGLFNAFGRLLWGIVADFFGGRLSTLS------ILLTILGLGLCAFLFLLKMTPVGLVLTGSLLG 309
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 346 FCVHFAGTSAWGLVQVMVSETKVASIAGIQNFGSFVFASFAPIVTGWVVDTTHSFNLALVIAACVTFTGA 415
Cdd:cd17314 310 FSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLAS 379
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
30-396 |
2.93e-07 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 52.26 E-value: 2.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 30 MAGIVNFLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGMVN 109
Cdd:cd17476 5 GAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSP 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 110 SFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQ-KERGTALGIFNSSTVIGQAI-APPALVLMQLAWgWRTMFVIIGVAG 187
Cdd:cd17476 85 NFIFFIICRALQGLGPAFLLPNAMALLGRTYPPgPRKNIVFSLFGATAPLGFALgGVFGGLFAQLAW-WPWIFWFLAILA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 188 ILVGICWYAWYRNRAQFVLtdeertylsapvkprpqlqfsewLALFkhrttwgmiLGFSGVNytGWLYIAWLpgYLQAEQ 267
Cdd:cd17476 164 AIVAVAAIFWTSPSFIAVL-----------------------LAVF---------LGWASFG--IWVFYATQ--YFQNVR 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 268 GFSLAktgwVAAIPFLAAAVGMWVNGIVVdrlakkGYDLAKTRKTAIVCGLMMS-ALGTLLVVQSSSPAQAVAFISMALF 346
Cdd:cd17476 208 GYSPL----LTSARFIPMAIGGVLAAITV------GFLIARLPPSYIMAISMVAfLVGPILFATMPVHQTYWAQAFPAMI 277
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1618847556 347 CVHFAGTSAWGLVQVMVSET---KVASIAG-----IQNFGSFVFASFAPIVTGWVVDT 396
Cdd:cd17476 278 VAPFGMDFSFPAATIIASNAvprEYQGLAGslvntVVNYGISIGLGIAGTVETSVNED 335
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
49-203 |
7.78e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 50.64 E-value: 7.78e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 49 IRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPR--IVLGAGLIFWSLMQALTGMVNSFSHFILMRIGLGIGEA 126
Cdd:COG2271 207 LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLG 286
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1618847556 127 PFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVIIGVAGILVGICWYAWYRNRAQ 203
Cdd:COG2271 287 GAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
33-396 |
1.02e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 50.40 E-value: 1.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 33 IVNFLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGMVNSFS 112
Cdd:cd17333 6 FSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIY 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 113 HFILMRIGLGIGEAPFMPAGVKSITDWYaQKERGTALGIFNSSTVIGQAIAPP---ALVLMQLAWGWrtMFVIIGVAGIL 189
Cdd:cd17333 86 LFVVLMFLAGLGAGILDTGANTFVGALF-EESSATRLNVLHGFFGLGALIGPLiatSLLTSELSWSW--AYLIIGLIYLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 190 VGICWYawyrnRAQFVLTDEERTYLSAPVKPRPQLQFSEWlaLFKHRTTWGMILGFSGVNYTgwlYIAWLPGYLQAEQGF 269
Cdd:cd17333 163 LAILIL-----LTLFPELPSARNPQQSVGAFSASASRLLR--NPSIILGALALFLYVGAETA---FSSWVPSYLVEKKHV 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 270 SLAKTGWVAAIPFLAAAVGMWVNGIVVDRLAKKGYdlaktrkTAIVCGLMMsaLGTLLVVQSSSPA-QAVAFISMALFC- 347
Cdd:cd17333 233 SDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTL-------LVLSGSGAL--LGLLILLLAPTLVvGLVATALLGLFMa 303
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1618847556 348 VHFAGTSAWGLVQVMVSETKVASIagIQNFGSFVFAsFAPIVTGWVVDT 396
Cdd:cd17333 304 ALFPTILSLGISNLPYAKGKGTSV--LLAAGSIGGA-IIPFIMGFIAEA 349
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
56-192 |
1.12e-06 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 50.39 E-value: 1.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 56 SATEF-GVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGMVNSFSHF------ILMRIGLGIGEAPF 128
Cdd:cd17342 60 DAALFlGVLDTIFLFSYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTEWLHFynkylyCILWVLNGLLQSTG 139
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1618847556 129 MPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIApPALVLMQLAWGWRTMFVIIGVAGILVGI 192
Cdd:cd17342 140 WPCVVAIMGNWFGKSSRGFVLGLWSACASVGNIIG-ALLASSVLDYGYEYAFLVTSSLLFAGAI 202
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
48-294 |
1.21e-06 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 50.29 E-value: 1.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 48 AIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGMVNSFSHFILMRI--GLGIGE 125
Cdd:PRK11652 33 DMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAiqGLGTGV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 126 APFMpagVKSIT-DWYAqkerGTALGIFNS----STVIGQAIAPPALVLMQLAWGWRTMFVIIGVAGILVGICWYAWYRN 200
Cdd:PRK11652 113 GGVM---ARTLPrDLYE----GTQLRHANSllnmGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMARWMPE 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 201 raqfvltdeertylSAPVKPRPQLQFSEWLALFKHRTTWG----MILGF---------SGVNYTG----------WLYIA 257
Cdd:PRK11652 186 --------------TRPADARRTRVLASYRTLLSNRRFNCyllmLIGTLagiavfeacSGVLMGAvlglssmtvsILFIL 251
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1618847556 258 WLPGYL-----QAEQGFSLAKTGWVAAIPFLAAAVGMWVNGI 294
Cdd:PRK11652 252 PIPAAFfgawfAGRPNKRFSTLMWQSVICCLLAGLLMWIPGW 293
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
3-197 |
2.04e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 49.49 E-value: 2.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 3 VDVSTSVAGNKPQRIRRIQTVtLVLLFMAGIVNFLDRSSLSVAgeaIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILL 82
Cdd:cd17473 182 SAASPGAATAAALPWKRVLPI-YFLAFLAMLLFYVIPIQLPFL---LQERGGGSAALIGLALAIASLAGAIGALLFGRLK 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 83 DRFGPRIVLGAGLIFWSLMQALTGMVNSFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAI 162
Cdd:cd17473 258 RRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFL 337
|
170 180 190
....*....|....*....|....*....|....*.
gi 1618847556 163 APPAL-VLMQLAWGWRTMFVIIGVAGILVGICWYAW 197
Cdd:cd17473 338 SPLVLgPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-164 |
6.05e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.80 E-value: 6.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 17 IRRIQTVTLVLLFMAGIVNFLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPR---IVLGA 93
Cdd:pfam07690 194 WKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRrrlLLALL 273
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1618847556 94 GLIFWSLMQALTGMVNSFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAP 164
Cdd:pfam07690 274 LLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
53-199 |
8.79e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.59 E-value: 8.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 53 LGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGMV--NSFSHFILMRIGLGIGEAPFMP 130
Cdd:COG2211 259 LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILV 338
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 131 AGVKSITD-------WYAQKERGTALGIFNSSTVIGQAIAPP-ALVLMQLA-------------WGWRTMFVIIGVAGIL 189
Cdd:COG2211 339 LPWAMLADvvdydewKTGRRREGLYFGIFTFAIKLGQALAGAlAGLLLALFgyvagaaqspsalTGIRLLFFLLPAVLLL 418
|
170
....*....|
gi 1618847556 190 VGICWYAWYR 199
Cdd:COG2211 419 LAALLLLFYP 428
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
52-192 |
9.54e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 47.54 E-value: 9.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 52 ELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGMVNSFSH----FILMRIGLGIGEAp 127
Cdd:cd17370 228 ELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLlllgFILWGLYMGAQES- 306
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1618847556 128 FMPAGVKSITDwyaQKERGTALGIFNSSTVIGQAIAPpalVLMQLAWGWRTMFVIIGVAGILVGI 192
Cdd:cd17370 307 IERAAVADLVP---AELRGTAYGLFNTVVGIGWLLAS---LIAGYLWDLISPSAAFLFSAVLALI 365
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
53-193 |
1.16e-05 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 47.24 E-value: 1.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 53 LGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGMVNSFSHFILMRIGLGIGEAPFMPAG 132
Cdd:cd17313 276 YGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININP 355
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1618847556 133 VKSITDWYAQKER--GTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVIIGVAGILVGIC 193
Cdd:cd17313 356 YPLVSDYHSESGRgqGTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSLVG 418
|
|
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
49-192 |
1.22e-05 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 47.23 E-value: 1.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 49 IRGELGLSATEFGvLLSAFSLSYG-FSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGMVNSFSHFILMRIGLGIGEAP 127
Cdd:PLN00028 62 IRDNLNLTKSDIG-NAGIASVSGSiFSRLAMGPVCDLYGPRYGSAFLLMLTAPAVFCMSLVSSATGFIAVRFFIGFSLAT 140
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1618847556 128 FMPAGVksitdW----YAQKERGTALGIF----NSSTVIGQAIAPPALVLMQLAWG-----WRTMFVIIGVAGILVGI 192
Cdd:PLN00028 141 FVSCQY-----WmstmFNGKIVGTANGIAagwgNLGGGVTQLLMPLVFPLIKDAGApsftaWRIAFFVPGLLHIIMGI 213
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
17-199 |
1.49e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 46.80 E-value: 1.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 17 IRRIQTVTLVLLFMAGIVNFLdrSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVL----- 91
Cdd:COG2223 202 LRDPRFWLLSLLYFGTFGSFI--GFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLlivfa 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 92 GAGLIFWSLMQALTGMVNSFSHFILMRIGLGIGEAPFMpagvKSITDWYAQKERGTALGIFNSSTVIGQAIAPPAL-VLM 170
Cdd:COG2223 280 LMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVF----ALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFgALL 355
|
170 180
....*....|....*....|....*....
gi 1618847556 171 QLAWGWRTMFVIIGVAGILVGICWYAWYR 199
Cdd:COG2223 356 DATGSYTAAFLVFAVLALVALVLTLLLYR 384
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
28-346 |
1.67e-05 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 46.40 E-value: 1.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 28 LFMAGIVNFLDRSSLSVAGEAIRGELGlSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGM 107
Cdd:cd17502 1 LMLALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 108 VNSFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVI---IG 184
Cdd:cd17502 80 APNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYInlpIG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 185 VagilvgicwyawyrnraqfvltdeertylsapvkprpqlqfsewLALFKHRTTW-GMILGF-SGVNYTGWLYiaWLPGY 262
Cdd:cd17502 160 G--------------------------------------------LALALLRTILlSSIFGFlFGGALFGLIY--YLPLY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 263 LQAEQGFSLAKTGWVAAIPFLAAAVGMWVNGIVvdrLAKKGYdlakTRKTAIVCGLMMSALGTLLVVQSSSPAQAVAFIS 342
Cdd:cd17502 194 FQLVLGDSATKSGVRLLPLIIGLVIGSIISGAL---ISKTGR----YKPLIVIGTILMSVGAGLLTTLTLDTSKWLLIGY 266
|
....
gi 1618847556 343 MALF 346
Cdd:cd17502 267 LILL 270
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
241-425 |
3.48e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.49 E-value: 3.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 241 MILGFSGVNYTGWLYIAWLPGYLQAEQGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRLAkkgydlaktRKTAIVCGLMM 320
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFG---------RRRVLLIGLLL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 321 SALGTLLVVQSSSPAQAVAFISMALFCVHFAGTSAWGLVQVMVSETKVASIAGIQNFGSFVFASFAPIVTGWVVDtTHSF 400
Cdd:pfam07690 72 FALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS-LFGW 150
|
170 180
....*....|....*....|....*
gi 1618847556 401 NLALVIAACVTFTGALCYFFIVKDR 425
Cdd:pfam07690 151 RAAFLILAILSLLAAVLLLLPRPPP 175
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
53-203 |
3.66e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 45.62 E-value: 3.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 53 LGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGMVNSFSHFILMRIGLGIGEAPFMPAG 132
Cdd:COG0738 241 LGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTI 320
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1618847556 133 VkSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVIIGVAGILVGICWYAWYRNRAQ 203
Cdd:COG0738 321 F-SLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRK 390
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
15-195 |
3.72e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 45.68 E-value: 3.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 15 QRIRRIQTVTLVLLFMAgIVNFLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAG 94
Cdd:cd06173 202 RYLRRSPLLRLLLLALA-LFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIG 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 95 LIFWSLMQALTGMVNSFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAW 174
Cdd:cd06173 281 ALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAL 360
|
170 180
....*....|....*....|.
gi 1618847556 175 GWRTMFVIIGVAGILVGICWY 195
Cdd:cd06173 361 GLSAVFLLAGALLLLAALLLL 381
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
21-203 |
7.48e-05 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 44.72 E-value: 7.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 21 QTVTLVLLFMAGIVNFLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFG-PRIVLGAGLIFW- 98
Cdd:PRK14995 4 QWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGfKRLLMLGGTLFGl 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 99 -SLMQALTgmvNSFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQ-KERGTALGIFNSSTVIGQAIAP--PALVLMQLAW 174
Cdd:PRK14995 84 aSLAAAFS---PTASWLIATRALLAIGAAMIVPATLAGIRATFTEeKQRNMALGVWAAVGSGGAAFGPlvGGILLEHFYW 160
|
170 180
....*....|....*....|....*....
gi 1618847556 175 GwrTMFvIIGVAGILVGICWYAWYRNRAQ 203
Cdd:PRK14995 161 G--SVF-LINVPIVLVVMGLTARYVPRQA 186
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
236-424 |
7.88e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 44.49 E-value: 7.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 236 RTTWGMILGFsGVNYTGWLYIAWLPGYLQAEQGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRLakkgydlaKTRKTAIV 315
Cdd:COG2223 5 RVLLLATLAF-FLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRF--------GPRRVLLI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 316 CGLMMsALGTLLVVQSSSPAQAVAFISMALFCVHFAGTSAWGLVQVMVSETKVASIAGIQNFGSFVFASFAPIVTGWVVd 395
Cdd:COG2223 76 GLLLL-GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLI- 153
|
170 180
....*....|....*....|....*....
gi 1618847556 396 TTHSFNLALVIAACVTFTGALCYFFIVKD 424
Cdd:COG2223 154 AAFGWRNAFLILGILLLVVAVLAWLFLRD 182
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
236-426 |
1.45e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 43.74 E-value: 1.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 236 RTTWGMILGFSGVNYTGWLYIAWLPGYLQAEQGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRLAKKGydlaKTRKTAIV 315
Cdd:COG2211 10 KEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRW----GRRRPWIL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 316 CGLMMSALGTLLVVQSSSPAQAVAFISMALF------CVHFAGTSAWGLVQVMVSETKV-ASIAGIQNFGSFVFASFAPI 388
Cdd:COG2211 86 IGAIPLALSFVLLFTAPDLSPTGKLIYALVTylllglAYTLVNIPYSALGAELTPDYEErTRLSSWRFAFAGLGGLLASV 165
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1618847556 389 VTGWVV-----DTTHSFNLALVIAACVTFTGALCYFFIVKDRI 426
Cdd:COG2211 166 LPPPLVaafggDAALGYRLTALIFAVLGLLAFLLTFFGTKERP 208
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
52-185 |
2.02e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 43.34 E-value: 2.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 52 ELGLSATEFGVLLSAFSLSYGFSQLP-SGILLDRFGPRIVLGAGLIFWSLMQALTGMVNSFSHFILMRIGLGIGEAPFMP 130
Cdd:cd17330 204 RFGFSPSQIGLLLALVGIAGILAQLLlIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFP 283
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1618847556 131 AGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVIIGV 185
Cdd:cd17330 284 ALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAG 338
|
|
| OATP |
pfam03137 |
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ... |
54-299 |
2.14e-04 |
|
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.
Pssm-ID: 460821 [Multi-domain] Cd Length: 526 Bit Score: 43.34 E-value: 2.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 54 GLSATEFGVLLSafslSYGFSQLPSGILLDRFG-----PRIVlGAGlifwSLMQALTGMVNSFSHFILMRIG---LGIGE 125
Cdd:pfam03137 32 GLPSSLSGLISS----SYDIGNLLLIVFVSYFGgkghrPRWI-GVG----ALLMGLGSLLFALPHFLSFFLGqllLGIGG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 126 APFMPAGVKSITDwYAQKERGTA-LGIFNSSTVIGQAIA-------------PPALVLM--------QLAWgWRTmFVII 183
Cdd:pfam03137 103 TPIYTLGISYIDD-NVKKKNSPLyLGILYAVRVLGPALGfllgslclriyvdIGKVSITltpkdprwVGAW-WLG-FLIA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 184 GVAGILVGIcWYAWY----RNRAQFVLTDEERTYLSAPVKPRPQLQFSEWLALFKH--RTTWG-------MILGFSGVNY 250
Cdd:pfam03137 180 GLLLLLTAI-PFFFFpkslPGAAKRRAKKKKEPHSQDIADLKKTKSLKKLGPSLKDfpKALKRllknpvyMLLTLASVFE 258
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 1618847556 251 TGWL--YIAWLPGYLQAEQGFSLAK----TGWVaAIPFlaAAVGMWVNGIVVDRL 299
Cdd:pfam03137 259 FLLIagYATFLPKYIETQFGLSASTanllTGVV-AIPG--AALGILLGGLIIKKF 310
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
29-422 |
2.15e-04 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 43.41 E-value: 2.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 29 FMAGIVNFLDRSSLSVAGEAiRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFW---SLMQALT 105
Cdd:pfam00083 18 VIGAFLTLIDFFKNFGLSKS-VSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFvigAVLQGAA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 106 GMVNSFSHFILMRIGLGIGeapfmpAGVKSIT-----DWYAQKE-RGTALGIFNSSTVIGQ---AIAPPALVLMQLAWGW 176
Cdd:pfam00083 97 KGKWSVYQLIVGRVLVGIG------VGGASVLapmyiSEIAPKKlRGALGSLYQLAITFGIllaYIFGLGLNKTSNSDGW 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 177 RTMFVIIGVAGILVGICWY------AWYRNRAQFVLTDE--ERTYLSAPVKPR-----------PQLQFSEWLALF---- 233
Cdd:pfam00083 171 RIPLGLQLVPALLLIIGLLflpespRWLVEKGRLEEAREvlAKLRGVPDVDREldeikdsleagQEAEKASWKELFstkt 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 234 --KHRTTWGMILGFSgvNYTGWLYIAWLPGYLQAEQGFS--LAKTGWVAAIPFLAAAVGMWvngiVVDRLAKkgydlakt 309
Cdd:pfam00083 251 rrQRLLIGVMLQIFQ--QLTGINAIFYYSTTIFENLGLSdsFLVTIIVGVVNFVFTFIAIF----LVDRFGR-------- 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 310 RKTAIVCGLMMSAL------GTLLVVQSSSPAQAVAFISMALFCVHFAgTSAWGLVQVMVSE-------TKVASIAG-IQ 375
Cdd:pfam00083 317 RPLLLLGAAGMAICfvilgiVALLGVSKSDWAGIVAIVFIALFIAFFA-MGWGPVPWVIVSElfplsvrSKAMALATaAN 395
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 1618847556 376 NFGSFVFASFAPIVTgwvvDTTHSFNLALVIAACVTFTGALCYFFIV 422
Cdd:pfam00083 396 WLANFLIGFLFPIIT----DAIGLGYTFFIFAGLLVLFIIFVFFFVP 438
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
67-182 |
2.57e-04 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 42.99 E-value: 2.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 67 FSLSYGFSQLPS---GILLDRFGPRIVLGAGLIFWSLMQALTGMVNSFSHFILMRIGLGIgEAPFMPAGVKSITDWYAQK 143
Cdd:PRK09874 60 FSITFLFSAIASpfwGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGL-LGGFVPNANALIATQVPRN 138
|
90 100 110
....*....|....*....|....*....|....*....
gi 1618847556 144 ERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVI 182
Cdd:PRK09874 139 KSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFI 177
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
78-195 |
2.59e-04 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 42.95 E-value: 2.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 78 SGILLDRFGPRIVLGAGLIFWSLMQALTGMVNSFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTV 157
Cdd:cd17317 45 FGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGILFGLFWA 124
|
90 100 110
....*....|....*....|....*....|....*...
gi 1618847556 158 IGQAIAPPALVLMQlawGWRTMFVIIGVAGILVGICWY 195
Cdd:cd17317 125 LGYMLLALLAYLIR---DWRWLQLAISLPGLLFLLLLW 159
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
145-420 |
2.90e-04 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 42.67 E-value: 2.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 145 RGTALGIFNSSTVIGQAIAPPALVLMQL--------AWGWRTMFVIIGVAGILVgicwyAWYRNRAQFVLTDEERTylsA 216
Cdd:cd17367 135 RGFYSSFQYVTLIGGQLLALGVLLVLQHtlgedqmaAWGWRIPFLLGGVLAVVV-----LWLRRGLEETESFEAIA---E 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 217 PVKPRPQLqfseWLALFKHR----TTWGMILGFSGVNYTgwlYIAWLPGYLQAEQGFSLAKTGWVAAIPFLAAAVGMWVN 292
Cdd:cd17367 207 SNEASAGT----LRELRRHPrellLVVGLTAGGTLAFYT---WTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLG 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 293 GIVVDRLAKKGYDLAKTRKTAIVCGLMMSALGtllvvQSSSPAQAVAFISMALFCVHFaGTSAWGLVQVMVSETKV--AS 370
Cdd:cd17367 280 GRLSDRIGRRPLLLFFGIGGTLATVPLLSALD-----HTDSPYTAFALVLVGLVFLSG-YTSINAVVKAELFPTHVraLG 353
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 1618847556 371 IAGIQNFGSFVFASFAPIVTGWVVDTTHSFNLALVIAACVTFtGALCYFF 420
Cdd:cd17367 354 VGLPYALAVAIFGGTAPYVALWLKSIGHEWVFFWYVAGLIAI-SLVVYLR 402
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
49-412 |
3.26e-04 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 42.76 E-value: 3.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 49 IRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGMVNSFSHFILMRIGLGIGEAPF 128
Cdd:PRK03893 46 VQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGE 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 129 MPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFvIIGVAGILVgicwyAWYRNRAQFVLTD 208
Cdd:PRK03893 126 YGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALF-FIGILPIIF-----ALWLRKNLPEAED 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 209 -EERTYLSAPVKPRPQLQFSE----WLALFKHRTTWGMILGFSGVNYTGWLYI--------------------------- 256
Cdd:PRK03893 200 wKEKHAGKAPVRTMVDILYRGehriINILLTLAAAAALWFCFAGNLQNAAIVAvlgllcaaifisfmvqssgkrwptgvm 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 257 ----------------AWLPGYLQAEQGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRLAkkgydlakTRKtAIVCGLMM 320
Cdd:PRK03893 280 lmvvvlfaflyswpiqALLPTYLKTDLGYDPHTVANVLFFSGFGAAVGCCVGGFLGDWLG--------TRK-AYVCSLLI 350
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 321 SALgtLLVVQSSSPAQAVAFISMALFCVHFAGTSAWGLVQVMVS-----ETKVASIAGIQNFGSFVFAsFAPIVTGWVVD 395
Cdd:PRK03893 351 SQL--LIIPVFAIGGANVWVLGLLLFFQQMLGQGISGLLPKLIGgyfdtEQRAAGLGFTYNVGALGGA-LAPILGALIAQ 427
|
410 420
....*....|....*....|....*
gi 1618847556 396 TTH--------SFNLALVIAACVTF 412
Cdd:PRK03893 428 RLDlgtalaslSFSLTFVVILLIGL 452
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
25-341 |
3.38e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.55 E-value: 3.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 25 LVLLFMAGIVNFLDRSSLSVAGEAIrgelGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQAL 104
Cdd:cd17477 2 LLSVALLGLGSGLLLPLLSLRLERE----GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 105 TGMVNSFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAwGWrTMFVIIG 184
Cdd:cd17477 78 LALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTA-GA-LPFLIAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 185 VAgILVGICWYAWYRnraqfvltdeertylSAPVKPRPQLQFSEWLALFKHRTTWGMILGFSGVNYTGWlyiAWLPGYLQ 264
Cdd:cd17477 156 VL-LLLALVPLLLTR---------------RAAPEIEEAESISLRRLLRIAPLALLGAFVAGFLEGAFY---SLLPLYGL 216
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1618847556 265 aEQGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRLAKkgydlaktRKTAIVCGL--MMSALGTLLVVQSSSPAQAVAFI 341
Cdd:cd17477 217 -RLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDR--------RRVLLGCALlgALAALLLPLVPGLPLALLVLLFL 286
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
172-420 |
5.47e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 42.13 E-value: 5.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 172 LAWGWRTMFvIIGVAGILVGIcwyaWYRNRAQ----FVLTDEERTYLSAPVkprpqlqfseWLALFKH-RTTWGMILGFS 246
Cdd:cd17369 174 LSWGWRIPF-LLSAVLVAVGL----YIRLRLEetpvFRRAKEAGQVVRAPL----------VEVLRRHwRALLLAIGLRL 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 247 GVNYTGWLYIAWLPGYLQAEQGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRLakkgydlakTRKTAIVCG---LMMSAL 323
Cdd:cd17369 239 AENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRV---------GRRPVYLAGallAALFAF 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 324 GTLLVVQSSSPAQAVAFISMALFCVHFAGTSAWGLVQVMVSETKV----ASIAgiQNFGSFVFASFAPIVTGWVVDTTHS 399
Cdd:cd17369 310 PFFWLLDTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVrytgASLG--YQLGAILGGGFAPLIATALVAATGS 387
|
250 260
....*....|....*....|.
gi 1618847556 400 FNLALVIAACVTFTGALCYFF 420
Cdd:cd17369 388 WWPVALYLAALAVISLVAALF 408
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
52-195 |
5.92e-04 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 41.83 E-value: 5.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 52 ELGLSATEFGVLLSAfslsYGFSQLPSGILL----DRFGPRIVLGAGLIFWSLMQALTGMVNSFSHFILMRIGLGIGEAP 127
Cdd:cd17390 25 SLGASPTVIGLIGSV----YGALQLFSSPLVgswsDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHT 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1618847556 128 FMpaGVKS-ITDWYAQKERGTALGIFNSSTVIGqAIAPPAL--VLMQLAWGWRTMFVIIGVAGIL-VGICWY 195
Cdd:cd17390 101 QS--LCKAyLSDLVSEQERSRVLGRFNAASSLG-FILGPVVggHLAETDGGFYYVALLCSAIFILnAGLVWF 169
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
45-423 |
6.00e-04 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 41.78 E-value: 6.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 45 AGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPR-IVLGAGLIFwSLMQALTGMVNSFSHFILMRI--GL 121
Cdd:cd17359 23 ALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRkTLLISAVLF-FISALGSAFSPNFTIFIIARIigGL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 122 GIGEApfMPAGVKSITDWYAQKERGTALGIFNSSTVIGQ--------AIAPPALVLMQLAWGWRTMFVIIGVAGILVGIC 193
Cdd:cd17359 102 AVGGA--SALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQllayivnyLIANAGGADWLGAEGWRWMLGLEAIPAILFLLG 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 194 wyawyrnraqfvltdeertYLSAPVKPRpqlqfseWLALFKHRTTW-GMILG----FSGVNYTgwLYIAwlPGYLQaEQG 268
Cdd:cd17359 180 -------------------MLFIPESPR-------WLVSKGKPILIiGIGLAifqqFVGINVI--FYYG--PEIFQ-NAG 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 269 FS----LAKTGWVAAIPFLAAAVGMWvngiVVDRLAKKGYDLAKtrktAIVCGLMMSALGTLLVVQSSSPAQA-VAFISM 343
Cdd:cd17359 229 FSenaaLLQTIGIGVVNVIFTIIAIL----LVDKVGRKPLLLIG----SIGMAISLLLIGTAFYFAPGSQASGiVALVLI 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 344 ALFCVHFAGTsaWG-LVQVMVSET-------KVASIAGI-QNFGSFVFASFAPIvtgwVVDTTHSFNLALVIAACvtftG 414
Cdd:cd17359 301 LLFVAFFAMS--WGpVTWVLLSEIfpnrirgLAMGIAVFfLWIANFLVSLTFPI----LLAAFGLAFTFLIFAVI----C 370
|
....*....
gi 1618847556 415 ALCYFFIVK 423
Cdd:cd17359 371 VLAFLFVWK 379
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
25-192 |
7.21e-04 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 41.55 E-value: 7.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 25 LVLLFMAGIVNFLdrsslsVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQAL 104
Cdd:PRK10473 11 LVLLYPAGIDMYL------VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 105 TGMVNSFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVIIG 184
Cdd:PRK10473 85 CSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMA 164
|
....*...
gi 1618847556 185 VAGILVGI 192
Cdd:PRK10473 165 AMGILVLL 172
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
53-190 |
9.61e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 41.02 E-value: 9.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 53 LGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLI---FWSLMQALTGMVNSFSHFILMR----IGLGIGE 125
Cdd:cd17503 209 LGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLllaLGTLLLAFLTPDTSLWLIILPLfirgLGMGLVF 288
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1618847556 126 APFMPAGVKSITDwyaqKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVIIGVAGILV 190
Cdd:cd17503 289 MPLNTLALNSLPP----EQIGDATALFNTIRQLGGSIGTALLATLLTNRTQFHHSRLSELLAQQV 349
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
52-189 |
1.00e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 41.05 E-value: 1.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 52 ELGLSATEFGVLLSAfslsYGFSQL----PSGILLDRFGPR-IVLGAGLIFWSLMQALTGMVNSFSHFILMRIGLGIGEA 126
Cdd:cd17490 25 SLGASLSMIGIILGA----YGISQMllriPLGILSDRIGKRkLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAA 100
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1618847556 127 PFMPAGVkSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMF---VIIGVAGIL 189
Cdd:cd17490 101 TWVSFTV-LYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFllaALAGVLGFI 165
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
26-419 |
1.11e-03 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 40.95 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 26 VLLFMAGI---VNFLdrSSLSVageairgELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQ 102
Cdd:cd17337 6 VLLFMIGDgveQGFL--SPYLV-------DLGFSEAQAALLFTVYGLTVAIASWLSGVLAELFGPRRVMLIGLIIWLVFE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 103 A--LTGMVNSFSH-FILMRIGL-GIGEAPFMPAGVKSITDWYAQKERGTALGIFNSS-----TVIGQAIAPPAL-VLMQL 172
Cdd:cd17337 77 VlfLAFGLPSHNYpLMLLTYGLrGFGYPLFAYSFLVWITYRTPAERLGSAVGWFWFAftgglPVLGSYLASFTIpVIGEI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 173 AWGWRTMFVIIgvAGILVGIcwyawyrnraqFVLTDEERTYLSAPVKPRPQLQFSEWLALFKHRTTWGMILGFSGVNYTG 252
Cdd:cd17337 157 GTLWLSLVFVA--LGGLIAL-----------FLVRDRTGEQPLANPSEEPLKELLSGITILFRNPKIAIGGIVRIINTLS 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 253 WL-YIAWLPGYLQAEQGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRLakkGYdlaktRKTAIVCGLMMSALGTLL---V 328
Cdd:cd17337 224 QFgFPVFMPLYFTDTGGFSTSQWLQIWGIIFLVNIFFNLIFGILGDKI---GW-----RRTVRWFGGVGCAISTLLfyyV 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 329 VQSSSPAQAVAFISMALFCVHFAG---TSAwgLVQVMVSETKVASIAgIQNFGSFVFASFAPIVTGWVVDTTHSFNLALV 405
Cdd:cd17337 296 PQLFGHNYWAALIAAILFGIGLAGfvpLSA--LMPSLAPEHKGAAMS-ILNLGAGLSNFVGPAIVTLFLGSFGAGGVVWI 372
|
410
....*....|....
gi 1618847556 406 IAACVTFTGALCYF 419
Cdd:cd17337 373 FAGLYLLSAVLTLF 386
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
16-192 |
1.13e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 41.00 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 16 RIRRIQTVTLVLLFMAGIVNFLDRSSLSVAGEairgELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLgAGL 95
Cdd:cd17477 185 RLLRIAPLALLGAFVAGFLEGAFYSLLPLYGL----RLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVL-LGC 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 96 IFWSLMQALTGMVNSFSHFILMRIG--LGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLA 173
Cdd:cd17477 260 ALLGALAALLLPLVPGLPLALLVLLflWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDA 339
|
170
....*....|....*....
gi 1618847556 174 WGWRTMFVIIGVAGILVGI 192
Cdd:cd17477 340 FGPHGLFLFLAAVALLFLL 358
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
49-246 |
1.21e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 40.67 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 49 IRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGMVNSFSHFILMRIGLGIGEApf 128
Cdd:PRK11102 17 IAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAA-- 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 129 mpAGVKSIT----DWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVIIGVAGILVgICWYAWY------ 198
Cdd:PRK11102 95 --AASVVINalmrDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILA-AALVFFFipetlp 171
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1618847556 199 -RNRAQFVLTDEERTYLSapvkprpqlqfsewlaLFKHRTTWGMIL--GFS 246
Cdd:PRK11102 172 kERRQPFHLRTTIRNFAS----------------LFRHKRVLGYMLasGFS 206
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
52-416 |
1.27e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 40.60 E-value: 1.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 52 ELGLSATEFGVLLS-AFSLSYGFSqLPSGILLDRFGPR---IVLGAGLIFwsLMQALTGMVNSFSHFILMRIGLGIGEAP 127
Cdd:cd17370 28 VLGASAAAVGLIEGlAEALGSLLR-LFSGYLSDRTGKRkplVILGYGLSA--LAKPLLALAGSWQLVLLLRILERLGKGI 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 128 FMPAGVKSITDWYAQKERGTALGIFNSSTVIGqAIAPPALVLMQLAW---GWRTMF---VIIGVAGILVGICWYAWYRNr 201
Cdd:cd17370 105 RTPPRDALLADATPPSGRGKAFGLHRALDTLG-AVLGPLLAALLLYLlggNYRTIFllaAIPALLALLILLFVVKEYPR- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 202 aqfvltdeertylsaPVKPRPQLQFSEWLALFKHRTTWGMILGFSGVNYTGWLYIAwlpgYLQAEQGFSLAKTGWVAAIP 281
Cdd:cd17370 183 ---------------PPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFAFLI----LRAQELGLSAALIPLLYALF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 282 FLAAAVGMWVNGIVVDRlakkgydlaKTRKTAIVCGLMMSALGTLLVVQSSSPaqAVAFISMALFCVHFAGTSAWG--LV 359
Cdd:cd17370 244 NLVYALAAYPAGRLSDR---------IGRKKLLILGYLSLALAYLGFALGSSL--WLLLLGFILWGLYMGAQESIEraAV 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1618847556 360 QVMVSETKVASIAGIQNFGSFVFASFAPIVTGWVVDtTHSFNLALVIAACVTFTGAL 416
Cdd:cd17370 313 ADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWD-LISPSAAFLFSAVLALIALL 368
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
61-197 |
1.86e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 40.33 E-value: 1.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 61 GVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGMVNSFSHFILMRIGLGIGEAPFMPAGVKSITDWY 140
Cdd:cd17391 243 GLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKIT 322
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1618847556 141 AQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVIIGVAgILVGICWYAW 197
Cdd:cd17391 323 PKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALL-VLLNAIWSFI 378
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
56-412 |
1.93e-03 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 40.68 E-value: 1.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 56 SATEFGVLLS----AFSLSYGFSQLPSGILLDRFGPRIVL----GAGLIFWSLMQALTGMVNSFSHFILMRIgLGIGEAP 127
Cdd:PRK08633 41 DGSEQVILTAivnaLFLLPFLLLSSPAGFLADKFSKNRVIrivkLFEVGLTLLIVLAYYLGWFWLAFAVTFL-LGAQSAI 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 128 FMPAGVKSITDWYAQKERGTALGIFNSSTVI----GQAIAPpalVLMQLAWG-----WRTMFVIIGVAGILVGICWYAWY 198
Cdd:PRK08633 120 YSPAKYGIIPELVGKENLSRANGLLEAFTIVailaGTALFS---FLFESVNGntpseILGRIAPAGLVLLAVAVLGLIFA 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 199 RNRAQFVLTDEERTYLSAPVKPRpqLQFSEWLALFKHRTTWGMILGFSGVNYTGWLYIAWLPGYlqAEQGFSLAKTgWVA 278
Cdd:PRK08633 197 YRLPKVPAAAPEVFDKKKYLFPK--LLWRNLKLLRSDRVLWLAIIGLSYFWFISQLAQANFPAY--AKEVLGLDNT-FQV 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 279 AIPFLAAAVGMWVNGIVVDRLAKkgydlaKTRKTAIV----CGLMMSALgtLLVVQSSSPAQAVAF----ISMALFCV-- 348
Cdd:PRK08633 272 QYLLAASAIGIGIGSLLAGRLSG------RHIELGLVplgaLGLALSLF--LLPTAPSLASVLVLFflfgFSAGLFIVpl 343
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1618847556 349 -----HFAGTSAWGLVqvmvsetkvasIAG---IQNFGSFVFASFAPIVTGWVVDTTHSFNLALVIAACVTF 412
Cdd:PRK08633 344 naliqFRAPEKELGKV-----------LAAnnfLQNVGMLLFLALTTLFSGLGLSPAGLFYLIALVTLIGTL 404
|
|
| MFS_SLCO_OATP |
cd17336 |
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ... |
25-163 |
2.01e-03 |
|
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340894 [Multi-domain] Cd Length: 411 Bit Score: 40.30 E-value: 2.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 25 LVLLFMAGIVNFLDRSSLSVAGEAIRGELGLSATEFGVLLSafslSYGFSQLPSGILLDRFG-----PRIvLGAGLIFws 99
Cdd:cd17336 5 VVLLCLLGLLQGAVVSYFVSTITTIEKRFGLSSSQSGLILS----ANDIGQLLAVLLVSYFGgrghrPRW-IGIGSIL-- 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1618847556 100 lmQALTGMVNSFSHFILM-RIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIA 163
Cdd:cd17336 78 --MGLGCFLLALPHFLFVgQFLLGIGSSPLYTLGITYIDDNVSKKNSPLYIGILYAMRVLGPALG 140
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
25-189 |
2.41e-03 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 39.83 E-value: 2.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 25 LVLLFMAGIVNFLDRSSLSVAGEAIRGELGLSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQAL 104
Cdd:cd17372 1 LAYAGMGWVAEAMEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 105 TGMVNSFSHFILMR--IGLGIGEApfmPAGVKSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVI 182
Cdd:cd17372 81 SAFAPNYMWLIILRclVGLGLGGG---PQLASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAF 157
|
....*..
gi 1618847556 183 IGVAGIL 189
Cdd:cd17372 158 SSVPSSL 164
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
52-193 |
3.11e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 39.45 E-value: 3.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 52 ELGLSATEFGVLlsaFSLSYGFsQLP----SGILLDRFGPRIVLGAGLIFWSLMQALTGMVNSFSHFILMRIGLGIGEAP 127
Cdd:cd17471 229 ELGGSESWVGLL---FGLAAAL-EIPimllAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGI 304
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1618847556 128 FMPAGVkSITDWYAQKERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVIIGVAGILVGIC 193
Cdd:cd17471 305 TAGLGI-SYFQDLMPGQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVL 369
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
52-198 |
3.29e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 39.51 E-value: 3.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 52 ELGLSATEFGVLLSAFSLSYGFSQLPSGILL-DRFGPRIVLGAGLIFWSLMQALTGMVNSFSHFILMR----IGLGIGEA 126
Cdd:cd17490 224 QLGASSFQLGLLSIIYLLPNALASLLSGTLFyKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQalngFGTGILFP 303
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1618847556 127 PFMPAGVKSITDWyaqkERGTALGIFNSSTVIGQAIAPPALVLMQLAWGWRTMFVIIGVAGILVGICWYAWY 198
Cdd:cd17490 304 LLMSLSIEGVPAE----QRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLAYY 371
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
64-327 |
4.12e-03 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 39.15 E-value: 4.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 64 LSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQALTGMVNSFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQK 143
Cdd:PRK15402 54 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEA 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 144 E--RGTALgIFNSSTvigqaIAPPALVLMQLAW----GWRTMFVIIGVagiLVGICWYAWYRNRAQFVLTDEERTYLSAp 217
Cdd:PRK15402 134 DaiKITAL-MANVAL-----LAPLLGPLVGAALihvlPWRGMFVLFAA---LAALSFFGLWRAMPETAGRVGEKLSLKE- 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 218 vkprpqlQFSEWLALFKHRTTWG--MILGFSGVNYTGWlyIAWLPGYLQAEQGFSLAKTGwVAAIP-FLAAAVGMWVNGI 294
Cdd:PRK15402 204 -------LGRDYKLVLKNRRFVAgaLALGLVSLPLLAW--IALSPVILISGEQLSSYEYG-LLQVPvFGALIAGNLTLAR 273
|
250 260 270
....*....|....*....|....*....|....*.
gi 1618847556 295 VVDRLAkkgydLAKTRKTA---IVCGLMMSALGTLL 327
Cdd:PRK15402 274 LTSRRP-----LRSLIRMGlwpMVAGLLLAALATVI 304
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
239-426 |
4.45e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 39.13 E-value: 4.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 239 WGMILGFSGVNYTGWLYIAWLPGYLQAEQGFSLAKTGWVAAIPFLAAAVGMWVNGIVVDRLAkkgydlaktRKTAIVCGL 318
Cdd:cd17329 2 WVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFG---------RKPVMLAGL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 319 MMSALGTLLVVQSSSPAQAVAFISMALFCVHFAGTSAWGLVQVMVSETKVASIAGIQNFGSFVFASFAPIVTGWVVDttH 398
Cdd:cd17329 73 LLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL--Y 150
|
170 180
....*....|....*....|....*...
gi 1618847556 399 SFNLALVIAACVTFTGALCYFFIVKDRI 426
Cdd:cd17329 151 SFRLLFLAAAVLFLLAALVLLFLLPETR 178
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
79-301 |
5.01e-03 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 39.04 E-value: 5.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 79 GILLDRFGPRIVLGAGLIFWSLMQALTGMVNSFSHFILMRIGLGIGEAPFMPAGVKSITDWYAQKERGTALGIFNSSTVI 158
Cdd:PRK15403 72 GPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLV 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 159 GQAIAPPALVLMQLAWGWRTMFVIIGVAGILvgicwyAWYrnraqFVLTDEERTYLSAPVKPRPQLQFSEWLALFKHRT- 237
Cdd:PRK15403 152 APIIGPLSGAALMHFVHWKVLFAIIAVMGLI------AFV-----GLLLAMPETVKRGAVPFSAKSVLRDFRNVFRNRLf 220
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1618847556 238 -TWGMILGFSGVNYTGWlyIAWLPGYLQAEQGFSLAKTGWvAAIPFLAAAVgmwVNGIVVDRLAK 301
Cdd:PRK15403 221 lTGAATLSLSYIPMMSW--VAVSPVILIDAGGMTTSQFAW-TQVPVFGAVI---VANAIVARFVK 279
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
23-376 |
7.15e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 38.76 E-value: 7.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 23 VTLVLLFMAGIVNFldrSSLSVAGEAIRGELGlSATEFGVLLSAFSLSYGFSQLPSGILLDRFGPRIVLGAGLIFWSLMQ 102
Cdd:cd06179 1 AALCLAYFAQLFGV---TLPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 103 ALTGMVNSFSHFILMR--IGLGIGEAPFMPAGVKSItdwYAQKERGTALGIFNSSTVIGQAIAPP--ALVLMQLAWGWRT 178
Cdd:cd06179 77 IVAGTAKSVNMLIGGQalIGIGAGTQGLGAAVASEL---VPNKYRGLVQGVVNLVASPGSALGPLiaGALVEANAAGWRW 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 179 MF---------------------------------------------VIIGVAGILVGICW----YAWyrNRAQFVLTD- 208
Cdd:cd06179 154 IFyinaifnalalillfffyhppprpqlhgsstrqklkrldwvglflLIAGLVLFLLGLSWggnpYPW--SSAHVIAPLv 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 209 ------------EERTYLSAPVKPRpqlqfsewlALFKHRTtWGMILGFSGVnyTGWLYIAWLPGYLQaEQGFSLAKTGW 276
Cdd:cd06179 232 iggvlliafglyEWKGTKDGLLPPR---------LLFRGRN-FALILIVAFV--EGMIFYSLNIFWPQ-QISLLFTTDPL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618847556 277 VAAIPFLAAAVGMWVNGIVVDRLAKKGYDlakTRKTAIVCGLMMSA-LGTLLVVQSSSPAQAVAFISMALFCVHFAGTSA 355
Cdd:cd06179 299 KAGLYQLPFGLGTLFGAILAGLLLTKIKH---IKWQLVAGFVLFTAfLALLALITPDNKALAIAFSVLAGIGIGGPLVLA 375
|
410 420
....*....|....*....|.
gi 1618847556 356 WGLVQVMVSETKVASIAGIQN 376
Cdd:cd06179 376 IVIVQLSVPPEDIGTASGLLG 396
|
|
| |
