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Conserved domains on  [gi|1673828942|dbj|GDX75047|]
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4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [Cyanobium sp.]

Protein Classification

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase( domain architecture ID 11449259)

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol in isoprenoid biosynthesis

CATH:  3.30.230.10
EC:  2.7.1.148
Gene Ontology:  GO:0050515|GO:0005524|GO:0016310|GO:0016114
PubMed:  12878729
SCOP:  4000959|4000643

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 2-291 8.16e-99

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


:

Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 292.80  E-value: 8.16e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828942   2 TLTVEAPAKINLHLEVLGLRPDGYHELAMVMQSLDLADSLSFASTADAAITLECDRPELSTGSDNLIVKAAEMLRARAGL 81
Cdd:COG1947     1 SLTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPADDGSISLTGPGAGVPTDEDNLVYRAARLLQEATGI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828942  82 PeLGAHITLSKRIPIGAGLAGGSSDGAATLVGLNALWGCGFSAADLHAMAQALGSDMPFCLAGGTQLCFGRGEVMEPala 161
Cdd:COG1947    81 P-PGVDIHLEKRIPVGAGLGGGSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKLTP--- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828942 162 gqtsgsasagaaslvsgaAPAVPRFGVLLIKhPEASVSTPWAFGRCRDLRgdfyLETEADFEQRRQALRQGPLVAslaag 241
Cdd:COG1947   157 ------------------LPPLPELWLVLVK-PGVGVSTAEVYRALDLTR----DTPPPDIDALLAALAAGDAAL----- 208

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1673828942 242 gpLPALRNDLQAVV---EPEVASVgvgLALLRRApAALAVAMSGSGPSLFALF 291
Cdd:COG1947   209 --AALLRNDLEPVAfklYPEIAEV---LEALLEA-GALAARMSGSGSTVFGLF 255
 
Name Accession Description Interval E-value
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 2-291 8.16e-99

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 292.80  E-value: 8.16e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828942   2 TLTVEAPAKINLHLEVLGLRPDGYHELAMVMQSLDLADSLSFASTADAAITLECDRPELSTGSDNLIVKAAEMLRARAGL 81
Cdd:COG1947     1 SLTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPADDGSISLTGPGAGVPTDEDNLVYRAARLLQEATGI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828942  82 PeLGAHITLSKRIPIGAGLAGGSSDGAATLVGLNALWGCGFSAADLHAMAQALGSDMPFCLAGGTQLCFGRGEVMEPala 161
Cdd:COG1947    81 P-PGVDIHLEKRIPVGAGLGGGSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKLTP--- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828942 162 gqtsgsasagaaslvsgaAPAVPRFGVLLIKhPEASVSTPWAFGRCRDLRgdfyLETEADFEQRRQALRQGPLVAslaag 241
Cdd:COG1947   157 ------------------LPPLPELWLVLVK-PGVGVSTAEVYRALDLTR----DTPPPDIDALLAALAAGDAAL----- 208

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1673828942 242 gpLPALRNDLQAVV---EPEVASVgvgLALLRRApAALAVAMSGSGPSLFALF 291
Cdd:COG1947   209 --AALLRNDLEPVAfklYPEIAEV---LEALLEA-GALAARMSGSGSTVFGLF 255
ispE TIGR00154
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were ...
 1-291 3.93e-60

4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. It is now known, in tomato and E. coli, to encode 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 188029 [Multi-domain]  Cd Length: 294  Bit Score: 194.65  E-value: 3.93e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828942   1 MTLTVEAPAKINLHLEVLGLRPDGYHELAMVMQSLDLADSLSFASTADAAITLECDRPELSTgSDNLIVKAAEMLRARAG 80
Cdd:TIGR00154   1 MRHVFPAPAKINLFLYILGKRPDGYHELQMLMQFIDLGDKIIISVRSDDDIRLLKGDFDVPL-EENLAYRAAQLLKNFAN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828942  81 LPE---LGAHITLSKRIPIGAGLAGGSSDGAATLVGLNALWGCGFSAADLHAMAQALGSDMPFCLAGGTQLCFGRGEVME 157
Cdd:TIGR00154  80 SKIkslDGVNIEITKNIPMAAGLGGGSSDAAAVLVGLNQLWNLGLSLEELAELGATLGADVPFFVSGGTAFATGRGEIIT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828942 158 PAlagqtsgsasagaaslvsgAAPAVPRFgvlLIKHPEASVSTPWAFgrcRDLRGDfylETEADFEQRRQALRQGPLVAS 237
Cdd:TIGR00154 160 PF-------------------EDPPEKWV---VIAKPHVSVSTPVVY---QAYKLP---RNTPKRAKEWLKKISLECLQL 211

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1673828942 238 LAAGGplpalRNDLQAVVEPEVASVGVGLALLRRAPAAlAVAMSGSGPSLFALF 291
Cdd:TIGR00154 212 LDSNG-----LNDLEKVALKRHTEVAQALNWLLEYGLA-PERMSGSGPCVFALF 259
PRK14608 PRK14608
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 1-291 1.13e-50

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 237765 [Multi-domain]  Cd Length: 290  Bit Score: 170.03  E-value: 1.13e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828942   1 MTLTVEAPAKINLHLEVLGLRPDGYHELAMVMQSLDLADSLSFAstADAAITLECDRP---ELSTGSDNLIVKAAEMLRA 77
Cdd:PRK14608    5 PSLTEFAPAKINLALHVTGRRADGYHLLESLVAFADVGDRLTLE--PAEALSLTVSGPfaaGLGDGDDNLVLRAARALRA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828942  78 RAGLPELGAHITLSKRIPIGAGLAGGSSDGAATLVGLNALWGCGFSAADLHAMAQALGSDMPFCLAGGTQLCFGRGEVME 157
Cdd:PRK14608   83 RVGPGLPPGAFHLEKNLPVAAGIGGGSADAAAALRLLARLWGLALDDERLAALALSLGADVPVCLDSRPLIMRGIGEELT 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828942 158 PalagqtsgsasagaaslvsgaAPAVPRFGVLLIkHPEASVSTPWAFgRCRDLRgdfylETEADFEQRRQALRQGPLVAS 237
Cdd:PRK14608  163 P---------------------LPGLPSLPAVLV-NPGVPVATPDVF-RALGLR-----DGPPLPGAPDPLASADALLAA 214

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1673828942 238 LAAGgplpalRNDLQA---VVEPEVASVgvgLALLRRAPAALAVAMSGSGPSLFALF 291
Cdd:PRK14608  215 LAAT------RNDLEPpalALAPVIGEV---LAALRAQPGALLARMSGSGATCFALF 262
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 87-145 3.72e-09

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 52.17  E-value: 3.72e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1673828942  87 HITLSKRIPIGAGLAGGSSDGAATLVGLNALWGC-----GFSAADLHAMAQALGSDMPFCLAGG 145
Cdd:pfam00288   1 DIEIESNIPLGAGLGSSAALAVALLLALNELFGLplaklALEAEELAGGGRGGGMDVAASLYGG 64
 
Name Accession Description Interval E-value
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 2-291 8.16e-99

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 292.80  E-value: 8.16e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828942   2 TLTVEAPAKINLHLEVLGLRPDGYHELAMVMQSLDLADSLSFASTADAAITLECDRPELSTGSDNLIVKAAEMLRARAGL 81
Cdd:COG1947     1 SLTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPADDGSISLTGPGAGVPTDEDNLVYRAARLLQEATGI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828942  82 PeLGAHITLSKRIPIGAGLAGGSSDGAATLVGLNALWGCGFSAADLHAMAQALGSDMPFCLAGGTQLCFGRGEVMEPala 161
Cdd:COG1947    81 P-PGVDIHLEKRIPVGAGLGGGSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKLTP--- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828942 162 gqtsgsasagaaslvsgaAPAVPRFGVLLIKhPEASVSTPWAFGRCRDLRgdfyLETEADFEQRRQALRQGPLVAslaag 241
Cdd:COG1947   157 ------------------LPPLPELWLVLVK-PGVGVSTAEVYRALDLTR----DTPPPDIDALLAALAAGDAAL----- 208

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1673828942 242 gpLPALRNDLQAVV---EPEVASVgvgLALLRRApAALAVAMSGSGPSLFALF 291
Cdd:COG1947   209 --AALLRNDLEPVAfklYPEIAEV---LEALLEA-GALAARMSGSGSTVFGLF 255
ispE TIGR00154
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were ...
 1-291 3.93e-60

4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. It is now known, in tomato and E. coli, to encode 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 188029 [Multi-domain]  Cd Length: 294  Bit Score: 194.65  E-value: 3.93e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828942   1 MTLTVEAPAKINLHLEVLGLRPDGYHELAMVMQSLDLADSLSFASTADAAITLECDRPELSTgSDNLIVKAAEMLRARAG 80
Cdd:TIGR00154   1 MRHVFPAPAKINLFLYILGKRPDGYHELQMLMQFIDLGDKIIISVRSDDDIRLLKGDFDVPL-EENLAYRAAQLLKNFAN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828942  81 LPE---LGAHITLSKRIPIGAGLAGGSSDGAATLVGLNALWGCGFSAADLHAMAQALGSDMPFCLAGGTQLCFGRGEVME 157
Cdd:TIGR00154  80 SKIkslDGVNIEITKNIPMAAGLGGGSSDAAAVLVGLNQLWNLGLSLEELAELGATLGADVPFFVSGGTAFATGRGEIIT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828942 158 PAlagqtsgsasagaaslvsgAAPAVPRFgvlLIKHPEASVSTPWAFgrcRDLRGDfylETEADFEQRRQALRQGPLVAS 237
Cdd:TIGR00154 160 PF-------------------EDPPEKWV---VIAKPHVSVSTPVVY---QAYKLP---RNTPKRAKEWLKKISLECLQL 211

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1673828942 238 LAAGGplpalRNDLQAVVEPEVASVGVGLALLRRAPAAlAVAMSGSGPSLFALF 291
Cdd:TIGR00154 212 LDSNG-----LNDLEKVALKRHTEVAQALNWLLEYGLA-PERMSGSGPCVFALF 259
PRK14608 PRK14608
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 1-291 1.13e-50

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 237765 [Multi-domain]  Cd Length: 290  Bit Score: 170.03  E-value: 1.13e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828942   1 MTLTVEAPAKINLHLEVLGLRPDGYHELAMVMQSLDLADSLSFAstADAAITLECDRP---ELSTGSDNLIVKAAEMLRA 77
Cdd:PRK14608    5 PSLTEFAPAKINLALHVTGRRADGYHLLESLVAFADVGDRLTLE--PAEALSLTVSGPfaaGLGDGDDNLVLRAARALRA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828942  78 RAGLPELGAHITLSKRIPIGAGLAGGSSDGAATLVGLNALWGCGFSAADLHAMAQALGSDMPFCLAGGTQLCFGRGEVME 157
Cdd:PRK14608   83 RVGPGLPPGAFHLEKNLPVAAGIGGGSADAAAALRLLARLWGLALDDERLAALALSLGADVPVCLDSRPLIMRGIGEELT 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828942 158 PalagqtsgsasagaaslvsgaAPAVPRFGVLLIkHPEASVSTPWAFgRCRDLRgdfylETEADFEQRRQALRQGPLVAS 237
Cdd:PRK14608  163 P---------------------LPGLPSLPAVLV-NPGVPVATPDVF-RALGLR-----DGPPLPGAPDPLASADALLAA 214

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1673828942 238 LAAGgplpalRNDLQA---VVEPEVASVgvgLALLRRAPAALAVAMSGSGPSLFALF 291
Cdd:PRK14608  215 LAAT------RNDLEPpalALAPVIGEV---LAALRAQPGALLARMSGSGATCFALF 262
PRK03188 PRK03188
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 4-286 3.32e-50

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235110 [Multi-domain]  Cd Length: 300  Bit Score: 168.92  E-value: 3.32e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828942   4 TVEAPAKINLHLEVLGLRPDGYHELAMVMQSLDLADSLsfASTADAAITLECDRP---ELSTGSDNLIVKAAEMLRARAG 80
Cdd:PRK03188    2 TVRAPAKVNLHLGVGPLRDDGYHELATVFQAVSLYDEV--TVTAADVLSVEVSGEgadQVPTDESNLAWRAAELLAEHVG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828942  81 LPElGAHITLSKRIPIGAGLAGGSSDGAATLVGLNALWGCGFSAADLHAMAQALGSDMPFCLAGGTQLCFGRGEVMEPAL 160
Cdd:PRK03188   80 RAP-DVHLHIDKGIPVAGGMAGGSADAAAALVACDALWGLGLSRDELLELAAELGSDVPFALLGGTALGTGRGEQLAPVL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828942 161 AGQTSGSasagaaslvsgaAPAVPRFGvllikhpeasVSTPWAFGRCRDLRgdfyleteaDFEQRRQALRQGPLVASLAA 240
Cdd:PRK03188  159 ARGTFHW------------VLAFADGG----------LSTPAVFRELDRLR---------EAGDPPRLGEPDPLLAALRA 207

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1673828942 241 GGP---LPALRNDLQAV---VEPEVASVgvgLALLRRApAALAVAMSGSGPS 286
Cdd:PRK03188  208 GDPaqlAPLLGNDLQAAalsLRPSLRRT---LRAGEEA-GALAGIVSGSGPT 255
PRK14611 PRK14611
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
5-158 9.61e-27

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 184767 [Multi-domain]  Cd Length: 275  Bit Score: 106.38  E-value: 9.61e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828942   5 VEAPAKINLHLEVLGLRPDGYHELAMVMQSLDLADSLSFASTAdaAITLECDRPELSTgSDNLIVKAAEMLRARAGLpEL 84
Cdd:PRK14611    4 LLSPAKVNLGLWILGKRPDGYHEIFTIYHTIDLYDRIYIKEHH--TLEVKTSSPQIKE-EENIVYKALRLFERYTGI-DI 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1673828942  85 GAHITLSKRIPIGAGLAGGSSDGAATLVGLNALWGCGFSAADLHAMAQALGSDMPFCLAGGTQLCFGRGEVMEP 158
Cdd:PRK14611   80 NYSIFIEKNIPVGAGLGGGSSNAAVVLKYLNELLGNPLSEEELFELASSISADAPFFLKGGFALGRGIGDKLEF 153
PRK04181 PRK04181
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 4-158 1.12e-18

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235243  Cd Length: 257  Bit Score: 83.86  E-value: 1.12e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828942   4 TVEAPAKINLHLEVLGLRpDGYHELAMVMQSL-DLADSLSFASTADAAITLECD-RPELStgsDNLIVKAAEMLRARAGL 81
Cdd:PRK04181    2 VMKAYAKVNIFLKILGKR-GNYHELISRFVLVkDLFDEIEFVPKSAESFELIGNfDCPLE---ENIIYKAYQELKNKGFS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828942  82 PEL-----GAHITLSKRIPIGAGLAGGSSDGAATLVGLNALWGCGFSAADLHAMAQALGSDMPFCLAG-GTQLCFGRGEV 155
Cdd:PRK04181   78 NELieffkKKAIEVEKNIPTGAGLGGGSSDAATFLLMLNEILNLKLSLEELAEIGSKVGADVAFFISGyKSANVSGIGEI 157


                  ...
gi 1673828942 156 MEP 158
Cdd:PRK04181  158 VEE 160
PRK14613 PRK14613
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
7-158 6.83e-18

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 173077 [Multi-domain]  Cd Length: 297  Bit Score: 82.64  E-value: 6.83e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828942   7 APAKINLHLEVLGLRPDGYHELAMVMQSLDLADSLSFASTADAAITLECDR-------------PELSTGSDNLIVKAae 73
Cdd:PRK14613    3 SPAKINLGLEIPFKREDGFHEIRSVFLKISWGDDIEIEPAPNGVFELFSTNeiilekrklydqvSERGDIKQNILYKT-- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828942  74 MLRARAGLPEL-GAHITLSKRIPIGAGLAGGSSDgAATLVGLNALWGCGFSAADLHAMAQALGSDMPFCLAGGTQLCFGR 152
Cdd:PRK14613   81 FIKARSLFPELpGVKIHLTKRISPAGGLGGGSTN-AASLLNFLFSWRNFFTSDEMQVFAKEIGSDVPFFLGEGHAFVTGK 159


                  ....*.
gi 1673828942 153 GEVMEP 158
Cdd:PRK14613  160 GEIMEE 165
ThrB COG0083
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ...
 35-131 1.70e-10

Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 439853 [Multi-domain]  Cd Length: 302  Bit Score: 60.88  E-value: 1.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828942  35 LDLADSLSFASTADAAITLE---CDRPELSTGSDNLIVKAAEMLRARAGLPELGAHITLSKRIPIGAGLagGSSdGAAT- 110
Cdd:COG0083    25 LSLYDEVEVERSDEPGLEIEiegEGADELPTDEDNLVYQAALALLEKLGKEPPGLRIEIEKGIPLGRGL--GSS-AAAIv 101

                          90       100
                  ....*....|....*....|...
gi 1673828942 111 --LVGLNALWGCGFSAADLHAMA 131
Cdd:COG0083   102 agLVAANALLGLPLSKEELLELA 124
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 87-145 3.72e-09

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 52.17  E-value: 3.72e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1673828942  87 HITLSKRIPIGAGLAGGSSDGAATLVGLNALWGC-----GFSAADLHAMAQALGSDMPFCLAGG 145
Cdd:pfam00288   1 DIEIESNIPLGAGLGSSAALAVALLLALNELFGLplaklALEAEELAGGGRGGGMDVAASLYGG 64
PRK01212 PRK01212
homoserine kinase; Provisional
 65-325 7.62e-08

homoserine kinase; Provisional


Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 52.84  E-value: 7.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828942  65 DNLIVKAAEMLRARAGLPElGAHITLSKRIPIGAGLagGSSDGA--ATLVGLNALWGCGFSAADLHAMAqalgSDM---- 138
Cdd:PRK01212   62 KNLVYQAALKFLEKLGKPP-GLRIELEKNIPLGRGL--GSSAASivAGLVAANELAGLPLSKEELLQLA----TEGeghp 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828942 139 ----PfCLAGGTQLCFGRGEVmepalagqtsgsasagaaslVSGAAPAVPRFGVLLIkHPEASVSTpwafgrcRDLRG-- 212
Cdd:PRK01212  135 dnvaP-ALLGGLVLALEENGV--------------------ISVKIPVFDDLKWVVA-IPNIELST-------AEARAvl 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828942 213 -DFYLETEADFEQRRQALrqgpLVASLAAGGP--LPALRNDLqaVVEPEVASVGVGLALLRRAPA---ALAVAMSGSGPS 286
Cdd:PRK01212  186 pKQYSLKDAVFNSSRAAL----LVAALYTGDYelAGRAMKDV--LHEPYRAKLIPGFAEVRQAALeagALGAGISGAGPT 259

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1673828942 287 LFALFADAAGAEAARSALVGELTTAGFEVWCCRCTASGA 325
Cdd:PRK01212  260 VFALCDKEDAEKVADALQKAFLQGIEGFVHVLRLDTAGA 298
PRK05905 PRK05905
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
88-144 1.44e-03

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 235642  Cd Length: 258  Bit Score: 39.83  E-value: 1.44e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1673828942  88 ITLSKRIPIGAGLAGGSSDGAATLVGLNALWgcGFSAADLHAMAQALGSDMPFCLAG 144
Cdd:PRK05905   89 IKIKKRIPIGSGLGSGSSNAAVLMKWILEFE--GINEINYKDVVNKLGSDIPFFLSG 143
PRK03926 PRK03926
mevalonate kinase; Provisional
 62-131 2.45e-03

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 39.27  E-value: 2.45e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1673828942  62 TGSDNLIVKAA-EMLRARAglPELGAHITLSKRIPIGAGLAGGSSDGAATLVGLNALWGCGFSAADLHAMA 131
Cdd:PRK03926   53 TGEKHPYVSAAiEKMREEA--DKDGVTVSITSQIPVGSGLGSSAAVTVATIGALNRLLGLGLSLEEIAKLG 121
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 51-133 3.42e-03

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 38.67  E-value: 3.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828942  51 ITLECDRPELSTGSDNLIVKAAEMLRARAGLPELGAHITLSKRIPIGAGLagGSSdgAATLVG----LNALWGCGFSAAD 126
Cdd:COG1577    47 LGGTLDLDPLADAALRYIKAAIEAALEYLGLPLKGFDIEIDSEIPRKRGL--GSS--AAVAVAviraLAAFYGVELSKEE 122


                  ....*..
gi 1673828942 127 LHAMAQA 133
Cdd:COG1577   123 LFKLALE 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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