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Conserved domains on  [gi|1673828943|dbj|GDX75048|]
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ribosomal RNA small subunit methyltransferase A [Cyanobium sp.]

Protein Classification

ribosomal RNA small subunit methyltransferase A( domain architecture ID 10000482)

ribosomal RNA small subunit methyltransferase A specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle

CATH:  2.20.25.110
EC:  2.1.1.-|2.1.1.182
Gene Ontology:  GO:1904047|GO:0052908|GO:0031167
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 5-270 4.82e-101

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


:

Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 296.27  E-value: 4.82e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943   5 GHRARKRFGQHWLTDAAVLDRIVAAAAIEPGEHLLEVGPGRGALTERLLASpAASVLAIELDRDLVAGLRQRFGVDPRFQ 84
Cdd:COG0030     8 GLRPKKRLGQNFLIDPNIIRRIVDAAGITPGDTVLEIGPGLGALTRALLER-AARVTAVEIDRRLAAILRETFAAYPNLT 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943  85 LLEGDVLALPLLPPAGPAPEKVVANIPYNITGPLLERLVGRLDrplerPYRALVLLVQQEVGERIRARPGSSAYSALSVR 164
Cdd:COG0030    87 VIEGDALKVDLPALAAGEPLKVVGNLPYNISTPILFKLLEARP-----PIEDAVLMVQKEVAERLVAKPGSKDYGRLSVL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943 165 MQLLARCSTVCPVPPRCFSPPPKVNSELIRLDPLsPEQRLEPALARRTDALLRRCFAARRKMLRNTLAGLLPEVELQQAA 244
Cdd:COG0030   162 VQYYADVEILFTVPPEAFYPPPKVDSAVVRLTPR-PEPLVPVADEKLFFRVVKAAFSQRRKTLRNSLKSLFSKERLEEAL 240

                         250       260
                  ....*....|....*....|....*.
gi 1673828943 245 EAAGITLNQRPQELAPERWLALAAVL 270
Cdd:COG0030   241 EAAGIDPTARAEELSVEEFARLANAL 266
 
Name Accession Description Interval E-value
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 5-270 4.82e-101

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 296.27  E-value: 4.82e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943   5 GHRARKRFGQHWLTDAAVLDRIVAAAAIEPGEHLLEVGPGRGALTERLLASpAASVLAIELDRDLVAGLRQRFGVDPRFQ 84
Cdd:COG0030     8 GLRPKKRLGQNFLIDPNIIRRIVDAAGITPGDTVLEIGPGLGALTRALLER-AARVTAVEIDRRLAAILRETFAAYPNLT 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943  85 LLEGDVLALPLLPPAGPAPEKVVANIPYNITGPLLERLVGRLDrplerPYRALVLLVQQEVGERIRARPGSSAYSALSVR 164
Cdd:COG0030    87 VIEGDALKVDLPALAAGEPLKVVGNLPYNISTPILFKLLEARP-----PIEDAVLMVQKEVAERLVAKPGSKDYGRLSVL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943 165 MQLLARCSTVCPVPPRCFSPPPKVNSELIRLDPLsPEQRLEPALARRTDALLRRCFAARRKMLRNTLAGLLPEVELQQAA 244
Cdd:COG0030   162 VQYYADVEILFTVPPEAFYPPPKVDSAVVRLTPR-PEPLVPVADEKLFFRVVKAAFSQRRKTLRNSLKSLFSKERLEEAL 240

                         250       260
                  ....*....|....*....|....*.
gi 1673828943 245 EAAGITLNQRPQELAPERWLALAAVL 270
Cdd:COG0030   241 EAAGIDPTARAEELSVEEFARLANAL 266
ksgA TIGR00755
ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, ...
 6-267 1.43e-79

ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, this protein is responsible for the dimethylation of two adjacent adenosine residues in a conserved hairpin of 16S rRNA in bacteria, 18S rRNA in eukaryotes. This adjacent dimethylation is the only rRNA modification shared by bacteria and eukaryotes. A single member of this family is present in each of the first 20 completed microbial genomes. This protein is essential in yeast, but not in E. coli, where its deletion leads to resistance to the antibiotic kasugamycin. Alternate name: S-adenosylmethionine--6-N',N'-adenosyl (rRNA) dimethyltransferase [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 273252 [Multi-domain]  Cd Length: 254  Bit Score: 241.37  E-value: 1.43e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943   6 HRARKRFGQHWLTDAAVLDRIVAAAAIEPGEHLLEVGPGRGALTERLLASpAASVLAIELDRDLVAGLRQRFGVDPRFQL 85
Cdd:TIGR00755   1 FRPRKSLGQNFLVDENVIRKIVEAANIQEGDRVLEIGPGLGALTEPLLKR-AKKVTAIEIDPRLAERLRKLLSLYNNLEI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943  86 LEGDVLALPLLPPAGPAPeKVVANIPYNITGPLLERLVGRLDrplerPYRALVLLVQQEVGERIRARPGSSAYSALSVRM 165
Cdd:TIGR00755  80 IEGDALKFDLNELAKDLT-KVVGNLPYNISSPLIFKLLKEKD-----AFKLAVLMVQKEVAERLVAKPGSKDYGRLSVLV 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943 166 QLLARCSTVCPVPPRCFSPPPKVNSELIRLDPLspEQRLEPALARRTDALLRRCFAARRKMLRNTLAGLLPEVElqQAAE 245
Cdd:TIGR00755 154 QYYANVEIVFKVPPSAFYPPPKVDSAVVRLVPL--KRKPSPKDFALFEELLKAAFQQRRKTLRNNLKNLLSELV--ELLE 229

                         250       260
                  ....*....|....*....|..
gi 1673828943 246 AAGITLNQRPQELAPERWLALA 267
Cdd:TIGR00755 230 ELGIDPDKRVEQLSPEDFLRLA 251
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
6-270 1.64e-64

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 202.82  E-value: 1.64e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943   6 HRARKRFGQHWLTDAAVLDRIVAAAAIEPGEHLLEVGPGRGALTERLLASpAASVLAIELDRDLVAGLRQRFGVDPRFQL 85
Cdd:PRK14896    1 IRMNKKLGQHFLIDDRVVDRIVEYAEDTDGDPVLEIGPGKGALTDELAKR-AKKVYAIELDPRLAEFLRDDEIAAGNVEI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943  86 LEGDVLALPLLPPagpapEKVVANIPYNITGPLLERLvgrldrpLERPYRALVLLVQQEVGERIRARPGSSAYSALSVRM 165
Cdd:PRK14896   80 IEGDALKVDLPEF-----NKVVSNLPYQISSPITFKL-------LKHGFEPAVLMYQKEFAERMVAKPGTKEYGRLSVMV 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943 166 QLLARCSTVCPVPPRCFSPPPKVNSELIRLDPLSPEqrLEPALARRTDALLRRCFAARRKMLRNTLAGL-----LPEVEL 240
Cdd:PRK14896  148 QYYADVEIVEKVPPGAFSPKPKVDSAVVRLTPREPK--YEVYDEDFFDDFVKALFQHRRKTLRNALKNSahisgKEDIKA 225

                         250       260       270
                  ....*....|....*....|....*....|
gi 1673828943 241 QQAAEAAGItLNQRPQELAPERWLALAAVL 270
Cdd:PRK14896  226 VVEALPEEL-LNKRVFQLSPEEIAELANLL 254
rADc smart00650
Ribosomal RNA adenine dimethylases;
22-197 1.17e-52

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 169.61  E-value: 1.17e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943   22 VLDRIVAAAAIEPGEHLLEVGPGRGALTERLLASpAASVLAIELDRDLVAGLRQRFGVDPRFQLLEGDVLALPLLPPAGP 101
Cdd:smart00650   1 VIDKIVRAANLRPGDTVLEIGPGKGALTEELLER-AKRVTAIEIDPRLAPRLREKFAAADNLTVIHGDALKFDLPKLQPY 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943  102 apeKVVANIPYNITGPLLERLVgrldrPLERPYRALVLLVQQEVGERIRARPGSSAYSALSVRMQLLARCSTVCPVPPRC 181
Cdd:smart00650  80 ---KVVGNLPYNISTPILFKLL-----EEPPAFRDAVLMVQKEVARRLAAKPGSKDYGRLSVLLQPYADVKILFKVPPSA 151

                          170
                   ....*....|....*.
gi 1673828943  182 FSPPPKVNSELIRLDP 197
Cdd:smart00650 152 FRPPPKVDSAVVRLER 167
RrnaAD pfam00398
Ribosomal RNA adenine dimethylase;
5-267 4.28e-52

Ribosomal RNA adenine dimethylase;


Pssm-ID: 395321 [Multi-domain]  Cd Length: 263  Bit Score: 171.39  E-value: 4.28e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943   5 GHRARKRFGQHWLTDAAVLDRIVAAAAIEPGEHLLEVGPGRGALTERLlASPAASVLAIELDRDLVAGLRQRFGVDPRFQ 84
Cdd:pfam00398   1 GNKFRTSYGQNFLKDPKVINEIVDKANLRESDTVLEIGPGKGALTVIL-AKRAKQVVAIEIDPRLAKLLQKKLSLDENLT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943  85 LLEGDVLALPLLPPAGPAPE--KVVANIPYNITGPLLERLvgrLDRPLErPYRALVLLVQQEVGERIRARPGSSAYSALS 162
Cdd:pfam00398  80 VIHQDFLKFEFPSLVTHIHQefLVVGNLPYNISTPIVKQL---LFESRF-GIVDMLLMLQKEFARRLLARPGSKLYSRLS 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943 163 VRMQLLARCSTVCPVPPRCFSPPPKVNSELIRLDPlSPEQRLEPALARRTDALLRRCFAARRKMLRNTLAGLLPEVELqQ 242
Cdd:pfam00398 156 VLRQAFTDVKLVAKVPPSIFSPPPKVDSALVRLER-HDPDPHPVKDLDVYDSVVRKLFNRKRKTLSTSLKSLFPGGQL-Q 233

                         250       260
                  ....*....|....*....|....*
gi 1673828943 243 AAEAAGITLNQRPQELAPERWLALA 267
Cdd:pfam00398 234 AFSSHGINDNALVKKLSPEQTLDIF 258
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 38-130 1.42e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 37.41  E-value: 1.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943  38 LLEVGPGRGALTERLLASPAASVLAIELDRDLVAGLRQRF--GVDPRFQLLEGDVlaLPLLPPAGPAPEKVVANIPYNIT 115
Cdd:cd02440     2 VLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAaaLLADNVEVLKGDA--EELPPEADESFDVIISDPPLHHL 79

                          90
                  ....*....|....*
gi 1673828943 116 GPLLERLVGRLDRPL 130
Cdd:cd02440    80 VEDLARFLEEARRLL 94
 
Name Accession Description Interval E-value
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 5-270 4.82e-101

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 296.27  E-value: 4.82e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943   5 GHRARKRFGQHWLTDAAVLDRIVAAAAIEPGEHLLEVGPGRGALTERLLASpAASVLAIELDRDLVAGLRQRFGVDPRFQ 84
Cdd:COG0030     8 GLRPKKRLGQNFLIDPNIIRRIVDAAGITPGDTVLEIGPGLGALTRALLER-AARVTAVEIDRRLAAILRETFAAYPNLT 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943  85 LLEGDVLALPLLPPAGPAPEKVVANIPYNITGPLLERLVGRLDrplerPYRALVLLVQQEVGERIRARPGSSAYSALSVR 164
Cdd:COG0030    87 VIEGDALKVDLPALAAGEPLKVVGNLPYNISTPILFKLLEARP-----PIEDAVLMVQKEVAERLVAKPGSKDYGRLSVL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943 165 MQLLARCSTVCPVPPRCFSPPPKVNSELIRLDPLsPEQRLEPALARRTDALLRRCFAARRKMLRNTLAGLLPEVELQQAA 244
Cdd:COG0030   162 VQYYADVEILFTVPPEAFYPPPKVDSAVVRLTPR-PEPLVPVADEKLFFRVVKAAFSQRRKTLRNSLKSLFSKERLEEAL 240

                         250       260
                  ....*....|....*....|....*.
gi 1673828943 245 EAAGITLNQRPQELAPERWLALAAVL 270
Cdd:COG0030   241 EAAGIDPTARAEELSVEEFARLANAL 266
ksgA TIGR00755
ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, ...
 6-267 1.43e-79

ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, this protein is responsible for the dimethylation of two adjacent adenosine residues in a conserved hairpin of 16S rRNA in bacteria, 18S rRNA in eukaryotes. This adjacent dimethylation is the only rRNA modification shared by bacteria and eukaryotes. A single member of this family is present in each of the first 20 completed microbial genomes. This protein is essential in yeast, but not in E. coli, where its deletion leads to resistance to the antibiotic kasugamycin. Alternate name: S-adenosylmethionine--6-N',N'-adenosyl (rRNA) dimethyltransferase [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 273252 [Multi-domain]  Cd Length: 254  Bit Score: 241.37  E-value: 1.43e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943   6 HRARKRFGQHWLTDAAVLDRIVAAAAIEPGEHLLEVGPGRGALTERLLASpAASVLAIELDRDLVAGLRQRFGVDPRFQL 85
Cdd:TIGR00755   1 FRPRKSLGQNFLVDENVIRKIVEAANIQEGDRVLEIGPGLGALTEPLLKR-AKKVTAIEIDPRLAERLRKLLSLYNNLEI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943  86 LEGDVLALPLLPPAGPAPeKVVANIPYNITGPLLERLVGRLDrplerPYRALVLLVQQEVGERIRARPGSSAYSALSVRM 165
Cdd:TIGR00755  80 IEGDALKFDLNELAKDLT-KVVGNLPYNISSPLIFKLLKEKD-----AFKLAVLMVQKEVAERLVAKPGSKDYGRLSVLV 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943 166 QLLARCSTVCPVPPRCFSPPPKVNSELIRLDPLspEQRLEPALARRTDALLRRCFAARRKMLRNTLAGLLPEVElqQAAE 245
Cdd:TIGR00755 154 QYYANVEIVFKVPPSAFYPPPKVDSAVVRLVPL--KRKPSPKDFALFEELLKAAFQQRRKTLRNNLKNLLSELV--ELLE 229

                         250       260
                  ....*....|....*....|..
gi 1673828943 246 AAGITLNQRPQELAPERWLALA 267
Cdd:TIGR00755 230 ELGIDPDKRVEQLSPEDFLRLA 251
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
6-270 1.64e-64

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 202.82  E-value: 1.64e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943   6 HRARKRFGQHWLTDAAVLDRIVAAAAIEPGEHLLEVGPGRGALTERLLASpAASVLAIELDRDLVAGLRQRFGVDPRFQL 85
Cdd:PRK14896    1 IRMNKKLGQHFLIDDRVVDRIVEYAEDTDGDPVLEIGPGKGALTDELAKR-AKKVYAIELDPRLAEFLRDDEIAAGNVEI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943  86 LEGDVLALPLLPPagpapEKVVANIPYNITGPLLERLvgrldrpLERPYRALVLLVQQEVGERIRARPGSSAYSALSVRM 165
Cdd:PRK14896   80 IEGDALKVDLPEF-----NKVVSNLPYQISSPITFKL-------LKHGFEPAVLMYQKEFAERMVAKPGTKEYGRLSVMV 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943 166 QLLARCSTVCPVPPRCFSPPPKVNSELIRLDPLSPEqrLEPALARRTDALLRRCFAARRKMLRNTLAGL-----LPEVEL 240
Cdd:PRK14896  148 QYYADVEIVEKVPPGAFSPKPKVDSAVVRLTPREPK--YEVYDEDFFDDFVKALFQHRRKTLRNALKNSahisgKEDIKA 225

                         250       260       270
                  ....*....|....*....|....*....|
gi 1673828943 241 QQAAEAAGItLNQRPQELAPERWLALAAVL 270
Cdd:PRK14896  226 VVEALPEEL-LNKRVFQLSPEEIAELANLL 254
PTZ00338 PTZ00338
dimethyladenosine transferase-like protein; Provisional
 10-228 2.76e-53

dimethyladenosine transferase-like protein; Provisional


Pssm-ID: 240367 [Multi-domain]  Cd Length: 294  Bit Score: 175.19  E-value: 2.76e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943  10 KRFGQHWLTDAAVLDRIVAAAAIEPGEHLLEVGPGRGALTERLLASpAASVLAIELDRDLVAGLRQRF---GVDPRFQLL 86
Cdd:PTZ00338   12 KKFGQHILKNPLVLDKIVEKAAIKPTDTVLEIGPGTGNLTEKLLQL-AKKVIAIEIDPRMVAELKKRFqnsPLASKLEVI 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943  87 EGDVLALPLLPPagpapEKVVANIPYNITGPLLERLVGRldRPLerpYRALVLLVQQEVGERIRARPGSSAYSALSVRMQ 166
Cdd:PTZ00338   91 EGDALKTEFPYF-----DVCVANVPYQISSPLVFKLLAH--RPL---FRCAVLMFQKEFALRLLAQPGDELYCRLSVNTQ 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1673828943 167 LLARCSTVCPVPPRCFSPPPKVNSELIRLDPLSPeqrLEPALARRTDALLRRCFAARRKMLR 228
Cdd:PTZ00338  161 LLCRVTHLMKVSKNSFNPPPKVESSVVRIEPKNP---PPDVDFEEWDGLLRICFSRKNKTLS 219
rADc smart00650
Ribosomal RNA adenine dimethylases;
22-197 1.17e-52

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 169.61  E-value: 1.17e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943   22 VLDRIVAAAAIEPGEHLLEVGPGRGALTERLLASpAASVLAIELDRDLVAGLRQRFGVDPRFQLLEGDVLALPLLPPAGP 101
Cdd:smart00650   1 VIDKIVRAANLRPGDTVLEIGPGKGALTEELLER-AKRVTAIEIDPRLAPRLREKFAAADNLTVIHGDALKFDLPKLQPY 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943  102 apeKVVANIPYNITGPLLERLVgrldrPLERPYRALVLLVQQEVGERIRARPGSSAYSALSVRMQLLARCSTVCPVPPRC 181
Cdd:smart00650  80 ---KVVGNLPYNISTPILFKLL-----EEPPAFRDAVLMVQKEVARRLAAKPGSKDYGRLSVLLQPYADVKILFKVPPSA 151

                          170
                   ....*....|....*.
gi 1673828943  182 FSPPPKVNSELIRLDP 197
Cdd:smart00650 152 FRPPPKVDSAVVRLER 167
RrnaAD pfam00398
Ribosomal RNA adenine dimethylase;
5-267 4.28e-52

Ribosomal RNA adenine dimethylase;


Pssm-ID: 395321 [Multi-domain]  Cd Length: 263  Bit Score: 171.39  E-value: 4.28e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943   5 GHRARKRFGQHWLTDAAVLDRIVAAAAIEPGEHLLEVGPGRGALTERLlASPAASVLAIELDRDLVAGLRQRFGVDPRFQ 84
Cdd:pfam00398   1 GNKFRTSYGQNFLKDPKVINEIVDKANLRESDTVLEIGPGKGALTVIL-AKRAKQVVAIEIDPRLAKLLQKKLSLDENLT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943  85 LLEGDVLALPLLPPAGPAPE--KVVANIPYNITGPLLERLvgrLDRPLErPYRALVLLVQQEVGERIRARPGSSAYSALS 162
Cdd:pfam00398  80 VIHQDFLKFEFPSLVTHIHQefLVVGNLPYNISTPIVKQL---LFESRF-GIVDMLLMLQKEFARRLLARPGSKLYSRLS 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943 163 VRMQLLARCSTVCPVPPRCFSPPPKVNSELIRLDPlSPEQRLEPALARRTDALLRRCFAARRKMLRNTLAGLLPEVELqQ 242
Cdd:pfam00398 156 VLRQAFTDVKLVAKVPPSIFSPPPKVDSALVRLER-HDPDPHPVKDLDVYDSVVRKLFNRKRKTLSTSLKSLFPGGQL-Q 233

                         250       260
                  ....*....|....*....|....*
gi 1673828943 243 AAEAAGITLNQRPQELAPERWLALA 267
Cdd:pfam00398 234 AFSSHGINDNALVKKLSPEQTLDIF 258
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 21-89 2.58e-07

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 49.16  E-value: 2.58e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1673828943  21 AVLDRIVAAAAIEPGEHLLEVGPGRGALTERLLASPAASVLAIELDRDLVAGLRQRF---GVDPRFQLLEGD 89
Cdd:COG2230    38 AKLDLILRKLGLKPGMRVLDIGCGWGGLALYLARRYGVRVTGVTLSPEQLEYARERAaeaGLADRVEVRLAD 109
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 24-90 2.20e-05

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 43.44  E-value: 2.20e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1673828943  24 DRIVAAAAIEPGEHLLEVGPGRGALTeRLLASPAASVLAIELDRDLVAGLRQRFG-VDPRFQLLEGDV 90
Cdd:COG2226    12 EALLAALGLRPGARVLDLGCGTGRLA-LALAERGARVTGVDISPEMLELARERAAeAGLNVEFVVGDA 78
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 39-90 1.29e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 37.16  E-value: 1.29e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1673828943  39 LEVGPGRGALTERLLASPAASVLAIELDRDLVAGLRQRFGVD-PRFQLLEGDV 90
Cdd:pfam13649   2 LDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAgLNVEFVQGDA 54
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 38-130 1.42e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 37.41  E-value: 1.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943  38 LLEVGPGRGALTERLLASPAASVLAIELDRDLVAGLRQRF--GVDPRFQLLEGDVlaLPLLPPAGPAPEKVVANIPYNIT 115
Cdd:cd02440     2 VLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAaaLLADNVEVLKGDA--EELPPEADESFDVIISDPPLHHL 79

                          90
                  ....*....|....*
gi 1673828943 116 GPLLERLVGRLDRPL 130
Cdd:cd02440    80 VEDLARFLEEARRLL 94
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
6-90 2.21e-03

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 38.48  E-value: 2.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943   6 HRARKRFGQHW----LTDAAVLDRIVAA--AAIEPGEHLLEVGPGRGALTerLLASP--AASVLAIELDRDLVAGLRQ-- 75
Cdd:COG4076     1 DYLMQFFVPRWhhpmLNDVERNDAFKAAieRVVKPGDVVLDIGTGSGLLS--MLAARagAKKVYAVEVNPDIAAVARRii 78

                          90
                  ....*....|....*.
gi 1673828943  76 -RFGVDPRFQLLEGDV 90
Cdd:COG4076    79 aANGLSDRITVINADA 94
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 26-90 5.82e-03

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 37.45  E-value: 5.82e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673828943  26 IVAAAAIEPGEHLLEVGPGRGALTERLLAS--PAASVLAIELDRDLVAGLRQ---RFGVDPRFQLLEGDV 90
Cdd:COG2519    83 IIARLDIFPGARVLEAGTGSGALTLALARAvgPEGKVYSYERREDFAEIARKnleRFGLPDNVELKLGDI 152
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 25-77 9.32e-03

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 36.60  E-value: 9.32e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1673828943  25 RIVAAAAIEPGEHLLEVGPGRG---ALTERLlaspAASVLAIELDRDLVAGLRQRF 77
Cdd:COG2518    57 RMLEALDLKPGDRVLEIGTGSGyqaAVLARL----AGRVYSVERDPELAERARERL 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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