|
Name |
Accession |
Description |
Interval |
E-value |
| murJ_mviN |
TIGR01695 |
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously ... |
269-798 |
2.23e-167 |
|
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously MviN), a family of integral membrane proteins predicted to have ten or more transmembrane regions. Members have been suggested to act as a lipid II flippase, translocated a precursor of murein. However, it appears FtsW has that activity. Flippase activity for MurJ has not been shown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273763 [Multi-domain] Cd Length: 502 Bit Score: 493.38 E-value: 2.23e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 269 GLLKSSAVMAAGTMVSRLTGFIRSALIVSALGVGLLGDTFQVAYQLPTMIYILTVGGGLNSVFVPQLVRAMKEDEDGGEA 348
Cdd:TIGR01695 1 SLLKSTLIVSLGTLFSRITGFVRDAIIASAFGAGLTADAFNVAFVIPNFFRRLFAEGAFNSAFVPVFTKAKKKEKEARRA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 349 FANRLLTLVMVALGVLTAITVFAAPLLIRLLSNPVASDPAAneVGITFVRYFLPSIFFMGLHVVMGQILNARGRFGAMMW 428
Cdd:TIGR01695 81 FANTVTTLLILSLLLVVLIGIFFAPFVISLLAPGFADETRS--LAVSLTRIMFPYLLLISLAAVFGGILNARKRFFIPSF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 429 TPVLNNIVIIVTLAMFIWVYGTAETSGMKVTSIppegerllgigvllGLVVQALAMIPYLRETGFRLRPRFDWKGHGLGK 508
Cdd:TIGR01695 159 SPILFNIGVILSLLFFDWNYGQYSLALAIGVLI--------------GGVAQLLIQLPFLRKAGFLLKPRFNFRDPGLKR 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 509 AVTLAKWTVLFVLANQAGAMIVIqlstaaGKASPVDGTGFAAYANAQLIWGLPQAIITVSLMAALLPRISRSASENDGGA 588
Cdd:TIGR01695 225 FLKLFLPTTLGSSASQITLLINT------ALASFLEIGSVSALYYANRIYQLPLGIFGISLSTVLLPKLSRHASEGNWNE 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 589 VRDDISQGLRTTAVAIVPVSFGFVALGIPMCTLMFGSS--GTSEATNMGYMLMAFGLGLIPYSVQYVVLRAFYAYEDTRT 666
Cdd:TIGR01695 299 LRDLLNQGIRLSLLLTIPSSFGLLILSIPIVSLLFERGafSEEDTVMTATILAAYGLGLIFYSLQKVLLRAFYARKDTRT 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 667 PFYNTVIVAVVNAmasgLCFLLLPSRWAVVGMAASYGLAYVTGVGVAWRRLRKRLGGDLDgPRVLRTYARLCIASvpaAL 746
Cdd:TIGR01695 379 PFINSVISVVLNA----LLSLLLIFPLGLVGIALATSAASMVSSVLLYLMLNRRLKGILP-FGVLKVLAKLVIAS---AI 450
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|..
gi 1903133744 747 ISGAACYAISRALGQDVLGSFAALLAGGVLLFGVFFVAARRMRIEEVNSLVG 798
Cdd:TIGR01695 451 IGGVLYLIVSVSLGGVLVKNLLGLLAIGLIGLLVYFLGLALLKIEELNLLLR 502
|
|
| MurJ |
pfam03023 |
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of ... |
295-773 |
1.06e-137 |
|
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of peptidoglycan precursor lipid II (undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-pentapeptide) on the cytosolic face of the cell membrane. Lipid II is then translocated across the membrane and its glycopeptide moiety becomes incorporated into the growing cell wall mesh. MviN, renamed as MurJ, is a lipid II flippase essential for cell wall peptidoglycan synthesis. MurJ belongs to the MVF (mouse virulence factor) family of MOP superfamily transporters, which also includes the MATE (multidrug and toxic compound extrusion) transporter and eukaryotic OLF (oligosaccharidyl-lipid flippase) families. In addition to the canonical MOP transporter core consisting of 12 transmembrane helices (TMs), MurJ has two additional C-terminal TMs (13 and 14) of unknown function. Structural analysis indicates that the N lobe (TMs 1-6) and C lobe (TMs 7-14) are arranged in an inward-facing N-shape conformation, rather than the outward-facing V-shape conformation observed in all existing MATE transporter structures. Furthermore, a hydrophobic groove is formed by two C-terminal transmembrane helices, which leads into a large central cavity that is mostly cationic. Mutagenesis studies, revealed a solvent-exposed cavity that is essential for function. Mutation of conserved residues (Ser17, Arg18, Arg24, Arg52, and Arg255) at the proximal site failed to complement MurJ function, consistent with the idea that these residues are important for recognizing the diphosphate and/or sugar moieties of lipid II. It has also been suggested that the chloride ion in the central cavity and a zinc ion at the beginning of TM 7 might be functionally important.
Pssm-ID: 397249 [Multi-domain] Cd Length: 451 Bit Score: 415.15 E-value: 1.06e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 295 IVSALGVGLLGDTFQVAYQLPTMIYILTVGGGLNSVFVPQLVRAMKEDEDGGEAFANRLLTLVMVALGVLTAITVFAAPL 374
Cdd:pfam03023 1 IAAYFGAGLLSDAFNVAFKIPNLLRRLFAEGAFSSAFIPVLAELKAQDKEEAAEFVRKVSTLLILVLLLVTLIGILAAPW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 375 LIRLLSNPvaSDPAANEVGITFVRYFLPSIFFMGLHVVMGQILNARGRFGAMMWTPVLNNIVIIVTLAMFIWVYGTAETS 454
Cdd:pfam03023 81 LIRLLAPG--FDPETFSLAVSLLRITFPYLLLVSLSAVFGAVLNARKKFFAPSFSPVLLNVGVILTLLLLANYLGNAIYA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 455 GMKVTSIppegerllgigvllGLVVQALAMIPYLRETGFRLRPRFDWKGHGLGKAVTLAKWTVLFVLANQAGAMIVIQLs 534
Cdd:pfam03023 159 LAIGVLI--------------GGVLQLLVQLPFLKKAGLLLKPRFGFRDKGLKRFLKLMLPTLLGVSVSQLNLLIDTFL- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 535 taagkASPVDGTGFAAYANAQLIWGLPQAIITVSLMAALLPRISRSASENDGGAVRDDISQGLRTTAVAIVPVSFGFVAL 614
Cdd:pfam03023 224 -----ASFLAPGSVSYLYYADRIYQLPLGIFGVSISTVLLPRLSRHAADGDWDEFRDLLDQAIRLTLLLMIPVSFGLLVL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 615 GIPMCTLMF--GSSGTSEATNMGYMLMAFGLGLIPYSVQYVVLRAFYAYEDTRTPFYNTVIVAVVNAMASglcfLLLPSR 692
Cdd:pfam03023 299 SIPIVSLLFerGNFSPEDVTATAEVLAAYALGLIPYALVKLLSRVFYAREDTKTPFKISLISAVLNILLS----LLLLPP 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 693 WAVVGMAASYGLAYVTGVGVAWRRLRKRLGGdlDGPRVLRTYARLciASVPAALISGAACYAISRALGQDVLGSFAALLA 772
Cdd:pfam03023 375 LGVAGLALATSLSSLIGLVFLYYILRKRLGG--FDLRGIKTFLAS--LVVPTALMAGVILLLSSLTQGPWVVGSLLLILV 450
|
.
gi 1903133744 773 G 773
Cdd:pfam03023 451 G 451
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
271-791 |
3.18e-136 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 413.39 E-value: 3.18e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 271 LKSSAVMAAGTMVSRLTGFIRSALIVSALGVGLLGDTFQVAYQLPTMIYILTVGGGLNSVFVPQLVRAM-KEDEDGGEAF 349
Cdd:COG0728 1 LRAALIVAIGTLLSRILGFVRDILIAAAFGAGAVADAFFVAFRIPNLLRRLFAEGALSAAFVPVLAEALeKEGEEEARRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 350 ANRLLTLVMVALGVLTAITVFAAPLLIRLLSNpvASDPAANEVGITFVRYFLPSIFFMGLHVVMGQILNARGRFGAMMWT 429
Cdd:COG0728 81 ASRVLTLLLLVLLVLTLLGILFAPLLVKLLAP--GFDPEKFALAVALTRIMFPYILFIGLSALLGGVLNARGRFAAPALA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 430 PVLNNIVIIVTLAMFIWVYGTAETS---GMKVTSIppegerllgigvllglvVQALAMIPYLRETGFRLRPRFDWKGHGL 506
Cdd:COG0728 159 PVLLNLVIIAGLLLLAPLFGPGIYAlawGVLLGGV-----------------LQLLIQLPALRRLGLRLRPRFDLRDPGV 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 507 GKAVTLAKWTVLFVLANQAGAMIVIQLSTAAGKASPvdgtgfAAYANAQLIWGLPQAIITVSLMAALLPRISRSASENDG 586
Cdd:COG0728 222 RRVLKLMLPALLGVSVSQINLLVDTILASFLPEGSV------SALYYADRLYQLPLGLFGVAIGTALLPRLSRAAAAGDL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 587 GAVRDDISQGLRTTAVAIVPVSFGFVALGIPMCTLMF--GSSGTSEATNMGYMLMAFGLGLIPYSVQYVVLRAFYAYEDT 664
Cdd:COG0728 296 EEFRRTLSRGLRLVLLLTLPAAVGLIVLAEPIVRLLFerGAFTAEDTALTALALAAYALGLPAFALVKVLARAFYARQDT 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 665 RTPFYNTVIVAVVNAmasGLCFLLLPsRWAVVGMAASYGLAYVTGVGVAWRRLRKRLGGdLDGPRVLRTYARLCIASVPA 744
Cdd:COG0728 376 RTPVRIAVIAVVVNI---VLNLLLVP-PLGHAGLALATSLSALVNALLLLVLLRRRLGG-LPLRGILRTLLKLLLASLVM 450
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 1903133744 745 ALISGAACYAISRALGQDVLGSFAALLAGGVLLFGVFFVAARRMRIE 791
Cdd:COG0728 451 GAVLWLLLRLLGDWLGGGLLGRLLALALLILVGAAVYFALLLLLGVR 497
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
278-720 |
1.63e-118 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 364.47 E-value: 1.63e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 278 AAGTMVSRLTGFIRSALIVSALGVGLLGDTFQVAYQLPTMIYILTVGGGLNSVFVPQLVRAM-KEDEDGGEAFANRLLTL 356
Cdd:cd13123 1 AIGTLLSRILGFVRDVLIAAAFGAGPLADAFFVAFRIPNLLRRLFAEGALSAAFVPVFSEYLeKEGEEEARRFASRVLTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 357 VMVALGVLTAITVFAAPLLIRLLSNPvaSDPAANEVGITFVRYFLPSIFFMGLHVVMGQILNARGRFGAMMWTPVLNNIV 436
Cdd:cd13123 81 LLLVLLLLTLLGILFAPLLVKLLAPG--FSGDKFELAVALTRIMFPYLLFISLSALLGGILNAHGRFFAPALAPVLLNLV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 437 IIVTLAMFIWVygtaetsgmkvtsiPPEGERLLGIGVLLGLVVQALAMIPYLRETGFRLRPRFDWKGHGLGKAVTLAKWT 516
Cdd:cd13123 159 IIAGLLLLAPL--------------FDLGIYALAWGVLLGGVLQLLVQLPALRRLGFRFRPRLDFRDPGVRRVLKLMLPA 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 517 VLFVLANQAGAMIVIQLSTAAGKASPvdgtgfAAYANAQLIWGLPQAIITVSLMAALLPRISRSASENDGGAVRDDISQG 596
Cdd:cd13123 225 LLGVSVSQINLLVDTILASFLPEGSI------SALYYADRLYQLPLGIFGVAIATALLPRLSRLAAAGDLDEFRRTLSRG 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 597 LRTTAVAIVPVSFGFVALGIPMCTLMF--GSSGTSEATNMGYMLMAFGLGLIPYSVQYVVLRAFYAYEDTRTPFYNTVIV 674
Cdd:cd13123 299 LRLVLFLLLPAAVGLIVLAEPIVRLLFerGAFTAEDTLMTASALAAYALGLPAFALVKLLSRAFYALKDTKTPVKIAVIA 378
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 1903133744 675 AVVNAMASglcfLLLPSRWAVVGMAASYGLAYVTGVGVAWRRLRKR 720
Cdd:cd13123 379 VAVNILLN----LLLIKPLGHVGLALATSLSAWVNALLLLVLLRRR 420
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
270-714 |
4.95e-23 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 101.56 E-value: 4.95e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 270 LLKSSAVMAAGTMVSRLTGFIRSALIVSALGVGLLGdTFQVAYQLPTMIYILtVGGGLNSVFVPQLVRamkEDEDGGEAF 349
Cdd:COG2244 4 LLKNTLWLLLGQLLGALLGFLLLPLLARLLGPEEYG-LFALALSIVALLSVL-ADLGLSTALVRFIAE---YREEELRRL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 350 ANRLLTLVMVALGVLTAITVFAAPLLIRLLSNPVAsdpaanevgITFVRYFLPSIFFMGLHVVMGQILNARGRFGAMMWT 429
Cdd:COG2244 79 LSTALLLRLLLSLLLALLLLLLAPFIAALLGEPEL---------ALLLLLLALALLLSALSAVLLALLRGLERFKLLALI 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 430 PVLNNIVIIVTLAMFIWVYGTAEtsgmkvtsippegerllgigvllglvvqALAMipylretgfrlrprfdwkghGLGKA 509
Cdd:COG2244 150 NILSSLLSLLLALLLALLGLGLW----------------------------GLVL--------------------KYSLP 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 510 VTLAkwTVLFVLANQAGAMIVIQLSTAAGkaspvdgtgFAAYANAQLIWGLPQAIITvSLMAALLPRISRSASENDGGAV 589
Cdd:COG2244 182 LLLS--GLLGLLLTNLDRLLLGALLGPAA---------VGIYSAAYRLASLLLLLIT-ALSQVLFPRLSRLLAEGDREEL 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 590 RDDISQGLRTTAVAIVPVSFGFVALGIPMCTLMFGssgtSEATNMGYMLMAFGLGLIPYSVQYVVLRAFYAYEDTRTPFY 669
Cdd:COG2244 250 RRLYRKALRLLLLLGLPLALGLALLAPPLLSLLFG----PEYAEAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLI 325
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 1903133744 670 NTVIVAVVNAmasGLCFLLLPsRWAVVGMAASYGLAYVTGVGVAW 714
Cdd:COG2244 326 ISLIGAVLNL---VLNLLLIP-RYGLVGAAIATLLSYLVLLLLLL 366
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
275-722 |
6.34e-19 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 90.22 E-value: 6.34e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 275 AVMAAGTMVSRLTGFI-RSAL--IVSALGVGLlgdtFQVAYQLPTMIYILTVGGglNSVFVPQLV---RAMKEDEDGGEA 348
Cdd:cd13124 1 LILTIAGLISKILGAIyRIPLqnIIGDEGMGL----YQMAYPIYGIFLTLATAG--IPVAISKLVaeyNALGDYKGARRI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 349 FanRLLTLVMVALG-VLTAITVFAAPLLIRLLSNpvasDPAAnevgITFVRYFLPSIFFMGLHVVMgqilnaRGRF-GAM 426
Cdd:cd13124 75 F--RVSLILLLILGlVFFLLLFFGAPFLAQLLLG----DPRL----APVIRALAPAILIVPLLSVL------RGYFqGLQ 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 427 MWTPV--------LNNIVIIVTLAMFI------WVY-GTAETSGMKVTSIppegerllgigvllglvVQALAMIPYlret 491
Cdd:cd13124 139 NMTPTavsqvieqIVRVIVILVLAYLLlpvgggLYYaAAGATFGAVIGAL-----------------AGLLVLLYY---- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 492 gFRLRPRFDWKGHGLGKAVTLAKWTVLFVLANQAG----------------AMIVIQLSTAAGKASPVDGTGFAAYA-NA 554
Cdd:cd13124 198 -YRKKRRELKRLLRKSPRSKISTKEILKELLSYAIpitlsslilpllqlidSFTVPRRLQAAGLSESEATALYGILTgRA 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 555 QLIWGLPqAIITVSLMAALLPRISRSASENDGGAVRDDISQGLRTTAVAIVPVSFGFVALGIPMCTLMFGSSgtseatNM 634
Cdd:cd13124 277 QPLVQLP-TVIATALSTSLVPAISEAYAKGDKKELRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGDS------EG 349
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 635 GYMLMAFGLGLIPYSVQYVVLRAFYAYEDTRTPFYNTVIVAVVNAmasgLCFLLLPSRWAVVGMAASYGLAYVTGVGVAW 714
Cdd:cd13124 350 GLILQILAPSILFLSLQQVTAAILQGLGKVKIPVINLLIGLLVKI----VLNYVLIPIFGIYGAAIATVIGFLVAALLNL 425
|
....*...
gi 1903133744 715 RRLRKRLG 722
Cdd:cd13124 426 RALKKLLG 433
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
270-718 |
1.26e-15 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 79.89 E-value: 1.26e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 270 LLKSSAVMAAGTMVSRLTGFIRSALIVSALGVGLLGdtfQVAYQLPTMIYILTV-GGGLNSVFVPQLVRAMKEDEDggEA 348
Cdd:cd13128 1 LAKNSGWLFVGNIISKLLGFLVRVYLARYLGPEGFG---ILSLALAFVGLFSIFaDLGLPTALVREIARYRKEKIR--EI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 349 FANrlLTLVMVALGVLTAITVFAAPLLIRLLSNPVasdpaanevgITFVRYFLPSIFFMGLHVVMGQILNARGRFGAMMW 428
Cdd:cd13128 76 IST--SLVLKLILGILALLLLFLFAFLIAFYDPEL----------VLLLYILALSLPFSALNSLFRGIFQGFEKMKYIVI 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 429 TPVLNNIVIIVTLAMFI------WVYGTAETSGMKVTSIppegerllgigvllglvvqaLAMIPYLRETGFRLRPRFDWK 502
Cdd:cd13128 144 ARIIESVLSLILALILVllggglIGFALAYLIASVLSAI--------------------LLLYIYRKKILLPKFFSFDLK 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 503 ghglgKAVTLAKWTVLFVLANqAGAMI-----VIQLSTAAGKASpvdgTGF--AAYANAQLIWGLPQAIITVslmaaLLP 575
Cdd:cd13128 204 -----LAKELLRFSIPLALSG-IFSLIytridTIMLGYFLGDAA----VGIynAAYRIAELLLFIPSAISTA-----LFP 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 576 RISRsASENDGGAVRDDISQGLRTTAVAIVPVSFGFVALGIPMCTLMFGssgtSEATNMGYMLMAFGLGLIPYSVQYVVL 655
Cdd:cd13128 269 RISE-LYKNDKDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFG----EEYLPAALVLQILAWGFLFIFLNGIFG 343
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1903133744 656 RAFYAYEDTRTPFYNTVIVAVVNAmasGLCFLLLPsRWAVVGMAASYGLAYVTGVGVAWRRLR 718
Cdd:cd13128 344 SILQAIGKQKLTLKILLIGALLNV---ILNLLLIP-KYGIIGAAIATLISEFIIFILLLYLLK 402
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
267-716 |
1.99e-11 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 66.71 E-value: 1.99e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 267 AGGLLKSSAVMAAGTMVSRLtgfirSALIVSALGVGLlgdtfqvayqlPTMIYILTVGGGLNSVFVPQLVRAM-KEDEDG 345
Cdd:COG0534 19 LGNLLQSLYGLVDTIFVGRL-----GTAALAAVGLAF-----------PIFFLLIALGIGLGVGGTALVAQALgAGDREE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 346 GEAFANRLLTLVMVALGVLTAITVFAAPLLIRLLSnpvaSDPAANEVGITFVRYFLPSIFFMGLHVVMGQILNARGRFGA 425
Cdd:COG0534 83 ARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLLG----ADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 426 MMWTPVLNNIVIIVTLAMFIWVYgtaetsGMKV------TSIppegerllgigvllGLVVQALAMIPYL--RETGFRLRP 497
Cdd:COG0534 159 PMIIMLIGNVLNIVLDPLLIFGG------GLGVagaalaTVI--------------SQAVSALLLLYYLfrKRSLLRLRL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 498 R-FDWKGHGLGKAVTLAKWTVLFVLANQAGAMIVIQLSTAAGKaspvdgTGFAAYANAQLIWGLPQAIItVSLMAALLPR 576
Cdd:COG0534 219 RdLRPDRKILKRILRIGLPAGLQQLAESLGFLVLNALVARLGT------AAVAAYGIALRIESLAFMPA-LGLGQAAQPL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 577 ISRSASENDGGAVRDDISQGLRTTAVAIVPVSFGFVALGIPMCTLMfgsSGTSEATNMG-YMLMAFGLGLIPYSVQYVVL 655
Cdd:COG0534 292 VGQNLGAGDYDRARRAARLALLLALGIGLLLALLLFLFPEPIIGLF---TDDPEVIALAaTYLRIAALFQPFDGLQFVLS 368
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1903133744 656 RAFYAYEDTRTPFYNTVIVAVVnaMASGLCFLLLPSRWAVVGMAASYGLAYVTGVGVAWRR 716
Cdd:COG0534 369 GALRGAGDTRFPMIISLLRLWL--VRLPLAYLLAFLGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_tuaB_like |
cd13127 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
357-725 |
3.35e-11 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides and participate in the biosynthesis of cell wall components such as teichuronic acid. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240532 [Multi-domain] Cd Length: 406 Bit Score: 65.97 E-value: 3.35e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 357 VMVALG-VLTAITVFAAPLLIRLLSNPVASDPaanevgitfVRYFLPSIFFMGLHVVMGQILNARGRFGAMMWTPVLNNI 435
Cdd:cd13127 77 LNLLLGlLLYLLLFLLAPLIAAFYNEPELIPL---------LRVLSLSFLLSGLGSVPRALLQRELRFKKLAIIELISTL 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 436 ---VIIVTLAMFiwvygtaetsGMKVTSIppegerllgigVLLGLVVQALAMIPYLRETGFRLRPRFDWKGH----GLGK 508
Cdd:cd13127 148 vsgVVAIVLALL----------GFGVWAL-----------VAQQLVGALVSTVLLWILSRWRPRLSFSLASLkellSFGS 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 509 AVTLAkwTVLFVLANQAGAMIViqlstaaGKASPVDGTGFaaYANAQLIWGLPQAIITVSLMAALLPRISRSAseNDGGA 588
Cdd:cd13127 207 KLLGS--NLLNYFSRNLDNLII-------GKFLGAAALGY--YSRAYRLALLPVQNITGPITRVLFPALSRLQ--DDPER 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 589 VRDDISQGLRTTAVAIVPVSFGFVALGIPMCTLMFGssgtSEATNMGYMLMAFGLGLIPYSVQYVVLRAFYAYEDTRTPF 668
Cdd:cd13127 274 LRRAYLKALRLLALITFPLMVGLALLAEPLVLLLLG----EKWLPAVPILQILALAGLFQPLSSLNGSLLLALGRTDLLL 349
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1903133744 669 YNTVIVAVVNamasgLCFLLLPSRWAVVGMAASYGLAYVTGVGVAWRRLRKRLGGDL 725
Cdd:cd13127 350 KLGLIKAVLT-----VLALLIGIPYGIIGVAIAYVIASLLSFPLNLYLAGRLIGISL 401
|
|
| Polysacc_synt_C |
pfam14667 |
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral ... |
637-790 |
3.06e-10 |
|
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.
Pssm-ID: 434111 [Multi-domain] Cd Length: 141 Bit Score: 59.12 E-value: 3.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 637 MLMAFGLGLIPYSVQYVVLRAFYAYEDTRTPFYNTVIVAVVNAmasGLCFLLLPsRWAVVGMAASYGLAYVTGVGVAWRR 716
Cdd:pfam14667 1 VLQILALSIIFLSLSTVLTSILQGLGRTKLALIALLIGALVKL---ILNLLLIP-LFGIVGAAIATVISLLVVALLNLYY 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1903133744 717 LRKRLGgdldgprvLRTYARLCIASVPAALISGAACYAISRALGQDVLGSFAALLAGGVLLFgVFFVAARRMRI 790
Cdd:pfam14667 77 LRRYLG--------LRLLLRRLLKPLLAALVMGIVVYLLLLLLGLLLGLALALLLAVLVGAL-VYLLLLLLLKL 141
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
277-713 |
1.22e-09 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 61.19 E-value: 1.22e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 277 MAAGTMVSRLTGFIRSALIVSALGVGLLGDTFqVAYQLPTMIYILTVGGGLNSVFVPQLVRAmkEDEDGGEAFANRLLTL 356
Cdd:cd12082 4 LLLSMLLQTLYNLVDTFFLGRLLGDALAAVGL-AFPLIALLIALGVGLSVGTSALISQAIGA--GDEEKARRVLVQSIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 357 VMVALGVLTAITVFAAPLLIRLLSnpvaSDPAANEVGITFVRYFLPSIFFMGLHVVMGQILNARGRFGAMMWTPVLNNIV 436
Cdd:cd12082 81 AILLGLLLAALLLFFSPLILSLLG----AEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 437 IIVTLamFIWVYGTAeTSGMKVTSIppegerllGIGVLLGLVVQALAMIPYLRETGFRLRPRFDWKG---HGLGKAVTLA 513
Cdd:cd12082 157 NILLD--PLLIFGLG-PPELGIAGA--------ALATVISYVIGALLLLIYLRKGKKILKFKLSLLKpdlELLRRLLRIG 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 514 KWTVLFVLANQAGAMIVIQLSTAAGKASPVdgtgfAAYANAQLIWGLPQAIItVSLMAALLPRISRSASendggavRDDI 593
Cdd:cd12082 226 LPSAIQNSLLSLGLLIIVAIVAAFGGAAAL-----AAYTVAFRIASLAFMPA-LGLAQAALPVVGQNLG-------AGNF 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 594 SQGLRTTAVAIVpvsFGFVALGIPMCTLMFG--------SSGTSEATNMGYMLMAFGLGLIPYSVQYVVLRAFYAYEDTR 665
Cdd:cd12082 293 DRARRITWVALL---IGLLIGAVLGLLILLFpepilslfTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTL 369
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 1903133744 666 TPFYNTVIVAVVNAMAsgLCFLLLPSRWAVVGMAASYGLAYVTGVGVA 713
Cdd:cd12082 370 KSLIVSLLSYWVVRLP--LAYVLAYLGLGLYGIWLALVISLILAALVL 415
|
|
| MATE_tuaB_like |
cd13127 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
282-446 |
3.97e-07 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides and participate in the biosynthesis of cell wall components such as teichuronic acid. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240532 [Multi-domain] Cd Length: 406 Bit Score: 53.26 E-value: 3.97e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 282 MVSRLTGFIRS----ALIVSALGVGLLGdTFQVAYQLPTMIyILTVGGGLNSVFVPQLVRAMKEDEDGGEAFAN--RLLT 355
Cdd:cd13127 209 LGSNLLNYFSRnldnLIIGKFLGAAALG-YYSRAYRLALLP-VQNITGPITRVLFPALSRLQDDPERLRRAYLKalRLLA 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 356 LVMVALGVLTAITvfaAPLLIRLL--SNPVASdpaanevgITFVRYFLPSIFFMGLHVVMGQILNARGRFGAMMWTPVLN 433
Cdd:cd13127 287 LITFPLMVGLALL---AEPLVLLLlgEKWLPA--------VPILQILALAGLFQPLSSLNGSLLLALGRTDLLLKLGLIK 355
|
170
....*....|...
gi 1903133744 434 NIVIIVTLAMFIW 446
Cdd:cd13127 356 AVLTVLALLIGIP 368
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
543-771 |
6.73e-07 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 52.45 E-value: 6.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 543 VDGTGFAAYANAQLIWGLPQAIITVsLMAALLPRISRSASENDGGAVRDDISQGLRTTAVAIVPVSFGFVALGIPMCTLM 622
Cdd:COG0534 38 LGTAALAAVGLAFPIFFLLIALGIG-LGVGGTALVAQALGAGDREEARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 623 FGSSGTSEATnMGYMLMAFgLGLIPYSVQYVVLRAFYAYEDTRTPFYNTVIVAVVNAmasGLCFLL-LPSRWAVVGMAAS 701
Cdd:COG0534 117 GADPEVLALA-RDYLRIIL-LGLPFLLLFNVLNGILRGLGDTKTPMIIMLIGNVLNI---VLDPLLiFGGGLGVAGAALA 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 702 YGLAYVTGVGVAWRRLRKRLGG---DLDGPRV-LRTYARLCIASVPAAL------ISGAACYAISRALGQDVLGSFAALL 771
Cdd:COG0534 192 TVISQAVSALLLLYYLFRKRSLlrlRLRDLRPdRKILKRILRIGLPAGLqqlaesLGFLVLNALVARLGTAAVAAYGIAL 271
|
|
| MATE_like_10 |
cd13125 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
272-707 |
3.32e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides, such as O-antigen. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240530 [Multi-domain] Cd Length: 409 Bit Score: 50.23 E-value: 3.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 272 KSSAVMAAGTMVSRLTGFIRS---ALIVSALGVGLLGdTFQVAYQLPTMIyiltVGGGLNSVFVPQLVRAmKEDEDggea 348
Cdd:cd13125 1 KVSSLSGISTLIKILAGLIINkvvAVYLGPSGVALLG-QLQNFVTILQTI----AGGGINNGVVKYTAEY-KDDEE---- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 349 fanRLLTLVMVALGVLTAITVFAAPLLIrLLSNPVASDPAANEVGITFVRYFLPSIFFMGLHVVMGQILNARGRFGAMMW 428
Cdd:cd13125 71 ---KLARVWSTAFRITLILSILGGLLLL-LFSKPLSSLLFGDIDYSWVFILLGLALPLFALNNLLLAILNGLKEIKRYAL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 429 TPVLNNIVIIVTLAMFIWVYGT--AETSGMKVTSIPpegerllgigvllglvvqALAMIPYLRETGFRLRPRFDWKGHgL 506
Cdd:cd13125 147 INIISSLIGLLVSVLLVYFYGLkgALLALVLNQSLI------------------FLVTLIYSRKQPWFKLKYLWGRLD-K 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 507 GKAVTLAKWTVLFVLANQAGAMIVIQLSTAAGKASPVDGTGFaayanAQLIWGLPQA---IITVSLMAALLPRISrSASE 583
Cdd:cd13125 208 DIIKKLLKFSLMALVSALSLPLSQIIVRNILIRQLGWEAAGY-----WQAVWKISDVylgFITTALSTYYLPRLS-AIKD 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 584 NDggAVRDDISQGLRTTAVAIVPVSFGFVALGIPMCTLMFgssgTSEATNMGYMLMAFGLGLI------PYSvqYVVLra 657
Cdd:cd13125 282 NK--ELKREVNKQLKVILPLVAIGALLIYLLRDLIIQILF----SEEFLPARELFLWQLIGDFfkiaswLLG--YILL-- 351
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 1903133744 658 fyAYEDTRTPFYNTVIVAVVNAmasGLCFLLLPsRWAVVGMAASYGLAYV 707
Cdd:cd13125 352 --AKGMTKLFIITEILFALLFV---LLSLLFIP-LFGLEGAGIAYAINYI 395
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
270-445 |
6.46e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 49.42 E-value: 6.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 270 LLKSSAVMAAGTMVSRLtgfirSALIVSALGVGLlgdtfQVAYQLPTMIYILTVGGglnSVFVPQLVRAmKEDEDGGEAF 349
Cdd:cd13134 17 LLQMLLGTIDTFMLSRY-----SDNAVAAVGVAN-----QILFLLILIFSFISTGT---SILIAQYLGA-KDKKKARQIA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 350 ANRLLTLVMVALgVLTAITVFAAPLLIRLLSNPvasdPAANEVGITFVRYFLPSIFFMGLHVVMGQILNARGRFGAMMWT 429
Cdd:cd13134 83 GVALLFNLLLGL-VFSLLLLFFGAELLRLMGLP----PELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYV 157
|
170
....*....|....*.
gi 1903133744 430 PVLNNIVIIVTLAMFI 445
Cdd:cd13134 158 SLIMNILNIVGNYLLI 173
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
278-421 |
6.87e-06 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 49.43 E-value: 6.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 278 AAGTMVSRLTGFIRSALIVSALGVGLLGdTFQVAYQLPTMIYILTVGGGL-NSVFVPQLVRAmkEDEDGGEAFANRLLTL 356
Cdd:cd13137 235 AGLEQLLRSLGFLVLLAIVASYGTAALA-AYQIGLRIESLAFMPGFGFSMaASTLVGQNLGA--GDPDEARRYGKRALRL 311
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1903133744 357 VMVALGVLTAITVFAAPLLIRLLSNpvasDPAANEVGITFVRYFLPSIFFMGLHVVMGQILNARG 421
Cdd:cd13137 312 GVLFMGLLGLLLFIFAPPLASLFTP----DPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAG 372
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
320-720 |
2.90e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 47.14 E-value: 2.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 320 ILTVGGGLNS---VFVPQLVRAmKEDEDGGEAFANRLLTLVMVALgVLTAITVFAAPLLIRLLsnpvASDPAANEVGITF 396
Cdd:cd13133 53 ILMLFFGLSSgvqVFVAQYNGA-GRYSRIGRVLWQGLYFSLLLAP-LLALLSALAAPLLFLLL----GHSPEVQALEVEY 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 397 VRYFLPSIFFMGLHVVMGQILNARGRFGAMMWTPVLNNIVIIVTLAMFIwvYGTAETSGMKV------TSIppegerllg 470
Cdd:cd13133 127 FRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLVMVVVNIVLDYALI--FGKLGFPAMGIagaaiaTVI--------- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 471 igvllGLVVQALAMIPYL------RETGFRLRPRFDWKG----------HGLGKAVTLAKWTVLFVLANQAG------AM 528
Cdd:cd13133 196 -----AEAVSLLFFLLLLfrrknrRRFGLRRAWRFDRELlrrilrlglpSGLQFFLDVGAFTVFFLLIGRLGttelaaTN 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 529 IVIQLSTAAGkaspVDGTGFAayanaqliwglpqaiITVSLMaallprISRSASENDGGAVRDDISQGLRTTAVAIVPVS 608
Cdd:cd13133 271 IVFSINSLAF----LPMIGLG---------------IAVSSL------VGQALGAGRPDLAMRVTRRGLKLALAYMLLLG 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 609 FGFVALGIPMCTLMFGSSGTSEATNMGYMLMAFGLG-LIPYSVQYVVLRAFYAYEDTRTPFYNTVIVAVvnAMASGLCFL 687
Cdd:cd13133 326 ILFLLFPELLLSIFTPGADFALIAELAVPLLRFVAAyILFDALALVFAGALRGAGDTRFVMLAELIVAW--LYLLPPAYL 403
|
410 420 430
....*....|....*....|....*....|....
gi 1903133744 688 LLPSRWAVVGMAASYgLAYVTGVGVA-WRRLRKR 720
Cdd:cd13133 404 LVVLGAGLAGAWTVE-TVYVIVLALIfLLRFRSG 436
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
541-720 |
4.20e-05 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 46.93 E-value: 4.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 541 SPVDGTGFAAYANAQLIWGLPQAIItVSLMAALLPRISRSASENDggavRDDISQGLRTTAVAIVPVSFGFVALGIPMCT 620
Cdd:cd12082 23 GRLLGDALAAVGLAFPLIALLIALG-VGLSVGTSALISQAIGAGD----EEKARRVLVQSIVLAILLGLLLAALLLFFSP 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 621 LMFGSSGTSEATN---MGYMLMAFgLGLIPYSVQYVVLRAFYAYEDTRTPFYNTVIVAVVNAMASGLC-FLLLPSRWAVV 696
Cdd:cd12082 98 LILSLLGAEEEVIelaATYLTILI-LGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNILLDPLLiFGLGPPELGIA 176
|
170 180
....*....|....*....|....
gi 1903133744 697 GMAASYGLAYVTGVGVAWRRLRKR 720
Cdd:cd12082 177 GAALATVISYVIGALLLLIYLRKG 200
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
282-720 |
9.66e-05 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 45.58 E-value: 9.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 282 MVSRLtgfirSALIVSALGVGLlgdtfQVAYQLPTMIYILTVGGglnSVFVPQLVRAmKEDEDGGEAFANRLLTLVMVAL 361
Cdd:cd13137 27 MVGRL-----GAEAIAAVGLAT-----QVLWLLLVLNMALGTGT---VALVSQSYGA-GDYERARRALGQSLLLALLLSL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 362 gVLTAITVFAAPLLIRLLSNpvasDPAANEVGITFVRYFLPSIFFMGLHVVMGQILNARGRFGAMMWTPVLNNIVIIVTL 441
Cdd:cd13137 93 -PLALLGLLFAEPLLRLLGA----DPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVNVLNIVLD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 442 AMFIwvYGTAETSGMKV------TSIppegerllgigvllglvVQALAMIPYL------RETGFRLRPRFDWKGHGLGKA 509
Cdd:cd13137 168 YVLI--FGLWGFPGLGVagaalaTVI-----------------SRVVGALLLLflllrgRLPIKISFKGFRLDRKIIKKL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 510 VTLAKWTVLFVLANQAGAMIVIQLSTAAGKASpvdgtgFAAYANAQLIWGLPqAIITVSLMAALLPRISRSASENDGGAV 589
Cdd:cd13137 229 LRIGLPAGLEQLLRSLGFLVLLAIVASYGTAA------LAAYQIGLRIESLA-FMPGFGFSMAASTLVGQNLGAGDPDEA 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 590 RDDISQGLRTTAVAIVPVSFGFVALGIPMCTLMfgsSGTSEATNMG-YMLMAFGLGLIPYSVQYVVLRAFYAYEDTRTPF 668
Cdd:cd13137 302 RRYGKRALRLGVLFMGLLGLLLFIFAPPLASLF---TPDPEVIELGvLYLRIVALSQPFLAISFVLSGALRGAGDTRPPL 378
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 1903133744 669 YNTVIVAVVNAMasGLCFLL-LPSRWAVVGMAASYGLAYVTGVGVAWRRLRKR 720
Cdd:cd13137 379 IINLISMWLVRL--PLAYLLgFVLGLGLTGIWLAMFVDTIVRAILLLYRFRKG 429
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
354-461 |
1.65e-04 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 44.76 E-value: 1.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 354 LTLVMVALGVLTAITVFAAPLLIRLLSNpvasDPAANEVGITFVRYFLPSIFFMGLHVVMGQILNArgrFGAMMWTPVLN 433
Cdd:cd13138 308 IIISLIIGLIIILLVFFFAPQLLGLFTS----DPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRG---LGKTKFPMIIS 380
|
90 100
....*....|....*....|....*...
gi 1903133744 434 NIVIIVTlaMFIWVYGTAETSGMKVTSI 461
Cdd:cd13138 381 ILRLWLV--RIPLAYLLSRLTGLGLFGI 406
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
554-791 |
1.79e-04 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 44.81 E-value: 1.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 554 AQLIWGLPQAIITvSLMAALLPRISRSASENDGGAVRDDISQGLRTTAVAIVPVSFGFVALGIPMCTLMfGSSGTSEATN 633
Cdd:cd13137 42 ATQVLWLLLVLNM-ALGTGTVALVSQSYGAGDYERARRALGQSLLLALLLSLPLALLGLLFAEPLLRLL-GADPEVIALA 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 634 MGYMLMAFgLGLIPYSVQYVVLRAFYAYEDTRTPFYNTVIVAVVNAmasGLCFLL------LPsRWAVVGMAASYGLAYV 707
Cdd:cd13137 120 LTYLRIVL-LGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVNVLNI---VLDYVLifglwgFP-GLGVAGAALATVISRV 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 708 TGVGV---AWRRLRKRLGGDLDGPRVLRTYA-RLCIASVPAALISGAacyaisRALGQDVLGSFaallaggVLLFGVFFV 783
Cdd:cd13137 195 VGALLllfLLLRGRLPIKISFKGFRLDRKIIkKLLRIGLPAGLEQLL------RSLGFLVLLAI-------VASYGTAAL 261
|
250
....*....|
gi 1903133744 784 AARR--MRIE 791
Cdd:cd13137 262 AAYQigLRIE 271
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
575-782 |
3.62e-04 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 43.70 E-value: 3.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 575 PRISRSASENDGGAVrddISQGLRTTAVAIVpVSFGFVALGIPMCTLMFGSSGTSEATN---MGYMLMAFgLGLIPYSVQ 651
Cdd:cd13136 65 GLVAQALGAGDREEA---IALLVRALLLALA-IGLLLILLQSPLLALALLLLGASAAVAalaRQYLRIRI-LGAPAVLLN 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 652 YVVLRAFYAYEDTRTPFYNTVIVAVVNAmasGLCFLL-LPSRWAVVGMAASYGLAYVTGVGVA-------WRRLRKRLGG 723
Cdd:cd13136 140 YVATGWFRGLQDTRTPLILQIVGNVVNI---VLDPLFvFGLGWGVAGAALATVIAQYLGALLGlwllrrrVRLLGKSLSR 216
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1903133744 724 DLDGPRVLRTYARL------CIASVPAALISGAACyaiSRALGQDVLGSFAALLagGVLLFGVFF 782
Cdd:cd13136 217 RLPSKAALKRLFKLnrdifiRTLALLAAFLFFTAL---AARLGDVILAANQILL--QFWLLSSYF 276
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
277-450 |
6.03e-04 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 42.94 E-value: 6.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 277 MAAGTMVSRLTGFIRSalIVSALGVGLLGDTFQVAYQLPTMIYILT---VGGGLNSvfvpqlvrAMkeDEDGGEAFANRL 353
Cdd:cd13132 8 LAAPLVLTSLLQYSLS--VVSVVFVGHLGKLELAAASLASSFANVTgfsILLGLAS--------AL--DTLCGQAFGAKN 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 354 LTLVMV----ALGVLTAITV-------FAAPLLIRLLSNPVASDPAAnevgiTFVRYFLPSIFFMGLHVVMGQILNARGR 422
Cdd:cd13132 76 YKLVGVylqrALVILLLCCVpisllwlNTEPILLLLGQDPEIARLAG-----EYLRWLIPGLFAYALFEPLKRYLQAQGI 150
|
170 180
....*....|....*....|....*...
gi 1903133744 423 FGAMMWTPVLNNIVIIVTLAMFIWVYGT 450
Cdd:cd13132 151 VLPLVYISLVALLLNILLNYLLVFVLGL 178
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
525-679 |
9.44e-04 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 42.49 E-value: 9.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 525 AGAMIVIQLSTAA---------GKASPVDgtgFAAYANAQLIWgLPQAIITVSLMAALLPRISRSASENDGGAVRDDISQ 595
Cdd:cd13131 9 ALPILIAQLAQMAmgfvdtvmaGRLGADD---LAAVALGSSLW-FPVFTFGMGLLLAVTPLVAQAHGAGDRRRIRRAVRQ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 596 GLRTTAVAIVPVSFGFVALGIPMctLMFGSSGTSEATNMGYmLMAFGLGLIPYSVqYVVLRAFY-AYEDTRTPFYNTVIV 674
Cdd:cd13131 85 GLWLALLLSLPLMLLLWLAPPIL--PLMGQEPEVAAIARGY-LLALAWGIPPALL-FQVLRSFLdALGRTRPAMVITLLA 160
|
....*
gi 1903133744 675 AVVNA 679
Cdd:cd13131 161 LVLNI 165
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
356-422 |
2.57e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 41.02 E-value: 2.57e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1903133744 356 LVMVALGVLTAITVFAAPLLIRLLSNpvasDPAANEVGITFVRYFLPSIFFMGLHVVMGQILNARGR 422
Cdd:cd13142 322 LIFLILVIGGVLAFLFAEPIVRVFIN----DPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGH 384
|
|
| Polysacc_synt |
pfam01943 |
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. ... |
270-579 |
4.17e-03 |
|
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. Many members of the family are implicated in production of polysaccharide. The family includes RfbX part of the O antigen biosynthesis operon. The family includes SpoVB from Bacillus subtilis, which is involved in spore cortex biosynthesis.
Pssm-ID: 426523 [Multi-domain] Cd Length: 274 Bit Score: 39.98 E-value: 4.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 270 LLKSSAVMAAGTMVSRLTGFIRSAL---IVSALGVGLlgdtFQVAYQLPTMIYILTvGGGLNSVFVPQLVRAMKEDEDGG 346
Cdd:pfam01943 1 LLKNVIVLLLSQLITYLLAFVTLPYlarILGPEGFGL----YAFALAFVGLLTIFT-DFGFNAALVREIAKYREKYELVS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 347 EAFANRLLTLVMVALGVLTAITVFAapllirllsnpvasdpaanEVGITFVRYFLPSIFFMGLHVVMGQ-----ILNARG 421
Cdd:pfam01943 76 LYWLNALLVKLVLVLLFLLLPLIAA-------------------FLGLPELAVLYRILALMFLLLPGVVqfrrgLFQGLE 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 422 RFGAMMWTPVLNNIVIIVTLAMFIWVYGTAETSGmkvtsippegerllgigvLLGLVVQALAMIPYLRETGFRLRPRFDW 501
Cdd:pfam01943 137 RMKYALISQIVESLSRVILVFIAVFLPGDIVAAL------------------LYQVLAALVGGIIALAVLRKIFRPRFVF 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 502 KGHGLGKAVTLAKWTVLFV-LANQAGA---MIVIQLSTAAGKAspvdgtgfAAYANAQLIWGLPQAIITVSLMAALLPRI 577
Cdd:pfam01943 199 PSLKLVRKLLSFGAPLFISsLAISLYTyidSILLGLLLGAGAV--------GIYNAAYQLLVAIQGLLNPIVTAVLFPVF 270
|
..
gi 1903133744 578 SR 579
Cdd:pfam01943 271 SK 272
|
|
| Polysacc_synt_3 |
pfam13440 |
Polysaccharide biosynthesis protein; |
493-625 |
4.18e-03 |
|
Polysaccharide biosynthesis protein;
Pssm-ID: 404342 [Multi-domain] Cd Length: 293 Bit Score: 39.88 E-value: 4.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 493 FRLRPRFDWKG----HGLGKAVTLAkwTVLFVLANQAGAMIViqlstaaGKASPVDGTGFaaYANAQLIWGLPQAIITVS 568
Cdd:pfam13440 163 WRPRLTFSLKVikelFSFGSWLLLS--NLLNYLARNLDNLII-------GKVLGTAALGL--YSVAYRLALLPTANITSV 231
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1903133744 569 LMAALLPRISRSasENDGGAVRDDISQGLRTTAVAIVPVSFGFVALGIPMCTLMFGS 625
Cdd:pfam13440 232 ITKVLFPALSRI--QDDKAKLRELYLRVLRLIAFIVFPIMAGLAVVAEPLVLVLLGS 286
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
517-711 |
9.22e-03 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 39.15 E-value: 9.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 517 VLFVLANQAGAMIViqlSTA-AGKASPVDgtgFAAYANAQLIWGLPQAIITVSLMAaLLPRISRSASENDGGAVRDDISQ 595
Cdd:TIGR00797 2 AILANILQPLLGLV---DTAfVGHLGPVD---LAAVSLGSSVFMFLFSILMGLGTA-TTALVAQAVGAGNYQRLGRQAQQ 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903133744 596 GLRTTAVAIVPVSFgFVALGIPMCTLMFGSSGTSEATNMGYMLMAFgLGLIPYSVQYVVLRAFYAYEDTRTPFYNTVIVA 675
Cdd:TIGR00797 75 SLLLALLLGLPVLL-VGYFFIDPLLSLMGADGEVAELAQDYLRILI-LGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGN 152
|
170 180 190
....*....|....*....|....*....|....*.
gi 1903133744 676 VVNAmasGLCFLLLPSRWavvGMAASYGLAYVTGVG 711
Cdd:TIGR00797 153 VINI---ILNYILIFGKF---GFLGIVGAALATVIS 182
|
|
| |
