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Conserved domains on  [gi|2771934002|dbj|GIC62280|]
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iron ABC transporter permease [Staphylococcus aureus]

Protein Classification

FecCD family ABC transporter permease( domain architecture ID 10001816)

FecCD family ABC transporter permease such as iron ABC transporter permease, which is the transmembrane subunit (TM) found in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter involved in the import of iron and iron-containing compounds

CATH:  1.10.3470.10
Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
SCOP:  4002900
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 39-339 3.46e-93

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 440374  Cd Length: 306  Bit Score: 280.03  E-value: 3.46e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002  39 MAIGSSKINFSDIVHYVTGHT-DTKATFLLHNVRMPRMIAGLFIGGALAVSGLLMQAMTRNPLASPKIFGVSSGASFFIV 117
Cdd:COG0609     2 LSLGAVPISLSDVLRALLGPDgDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 118 FVTIIIPSLEYYALYLG-VIGAFIGGLTVYTLSGATKGMTPIKLALAGMAIHLFFSSMTEGIIIL-NENSNEQVMFWLVG 195
Cdd:COG0609    82 LAIVLGGGLSALGLPLAaFLGALLAALLVYLLARRGGGLSPLRLVLAGVAVSALFSALTSLLLLLaDPEQLRSIVFWLMG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 196 SLSSMKWDEILTILPWLIGALIVTIFIGRQLTIMELGDDIAKGLGQNINKVRIIIGLLVIILTGMSVSVAGPIGFVGLIV 275
Cdd:COG0609   162 SLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLVV 241

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2771934002 276 PHIVKRYVSKNYLVMIPLTFIIGADLLLLSDVLSRLITYPYESPVGIVTSFVGALYFLFITIKG 339
Cdd:COG0609   242 PHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRR 305
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 39-339 3.46e-93

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 280.03  E-value: 3.46e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002  39 MAIGSSKINFSDIVHYVTGHT-DTKATFLLHNVRMPRMIAGLFIGGALAVSGLLMQAMTRNPLASPKIFGVSSGASFFIV 117
Cdd:COG0609     2 LSLGAVPISLSDVLRALLGPDgDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 118 FVTIIIPSLEYYALYLG-VIGAFIGGLTVYTLSGATKGMTPIKLALAGMAIHLFFSSMTEGIIIL-NENSNEQVMFWLVG 195
Cdd:COG0609    82 LAIVLGGGLSALGLPLAaFLGALLAALLVYLLARRGGGLSPLRLVLAGVAVSALFSALTSLLLLLaDPEQLRSIVFWLMG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 196 SLSSMKWDEILTILPWLIGALIVTIFIGRQLTIMELGDDIAKGLGQNINKVRIIIGLLVIILTGMSVSVAGPIGFVGLIV 275
Cdd:COG0609   162 SLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLVV 241

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2771934002 276 PHIVKRYVSKNYLVMIPLTFIIGADLLLLSDVLSRLITYPYESPVGIVTSFVGALYFLFITIKG 339
Cdd:COG0609   242 PHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRR 305
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 31-338 5.68e-88

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 266.70  E-value: 5.68e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002  31 LFICIYLNMAIGSSKINFSDIVHYVTGHTDTKATFLLHNVRMPRMIAGLFIGGALAVSGLLMQAMTRNPLASPKIFGVSS 110
Cdd:pfam01032   2 LLLLILLSLFIGAVKISPSDVFSALLGGDDSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 111 GASFFIVFVTIIIPSLEYYAL-YLGVIGAFIGGLTVYTLSGATKGMTPIKLALAGMAIHLFFSSMTEGIIIL-NENSNEQ 188
Cdd:pfam01032  82 GAALGAVLAILLGGSLSLFALpLAAFIGALLAALLVYFLSRGRGGASPLRLILAGIAVSALLSALTSLLLLLlNPEALQS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 189 VMFWLVGSLSSMKWDEILTILPWLIGALIVTIFIGRQLTIMELGDDIAKGLGQNINKVRIIIGLLVIILTGMSVSVAGPI 268
Cdd:pfam01032 162 ILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGPI 241

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 269 GFVGLIVPHIVKRYVSKNYLVMIPLTFIIGADLLLLSDVLSRLITYPYESPVGIVTSFVGALYFLFITIK 338
Cdd:pfam01032 242 GFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
66-329 1.58e-64

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 215.86  E-value: 1.58e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002  66 LLHNVRMPRMIAGLFIGGALAVSGLLMQAMTRNPLASPKIFGVSSGASFFIVFVTIIIPSL-EYYALYLGVIGAFIGGLT 144
Cdd:PRK10577   57 LLHYSRLPRLAIALLVGAALGLAGALLQQVLRNPLASPTTLGVAAGAQLALVLATLFAPALlALASQLAAFAGGLLAAAL 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 145 VYTLSGAtKGMTPIKLALAGMAIHLFFSSMTEGIIILNENSNEQVMFWLVGSLSSMKWDEILTILPWLIGALIVTIFIGR 224
Cdd:PRK10577  137 VFALAGG-KRLSPLRLVLAGMVVSLYLGALTTLLLLFNEQYLQGLFLWGAGSLAQNDWSGVQRLLPRLLVGLLLLLLLAR 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 225 QLTIMELGDDIAKGLGQNINKVRIIIGLLVIILTGMSVSVAGPIGFVGLIVPHIVKRYVSKNYLVMIPLTFIIGADLLLL 304
Cdd:PRK10577  216 PLTLLGLGDDVARSLGLAVSLTRLAALALAVLLSAAVVSAVGPIGFIGLAAPNLARLLGARRLRARLPLSPLIGALLLLL 295

                         250       260
                  ....*....|....*....|....*..
gi 2771934002 305 SDVLSRLITYPYES--PVGIVTSFVGA 329
Cdd:PRK10577  296 TDQLVRLLAGVGGEllPTGAVTALIGA 322
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 75-335 1.90e-52

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 173.90  E-value: 1.90e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002  75 MIAGLFIGGALAVSGLLMQAMTRNPLASPKIFGVSSGASFFIVFVTIIIPSLEYYALYLGVIGAFIGGLTVYTLSGATKG 154
Cdd:cd06550     1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLASRGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 155 MTPIKLALAGMAIHLFFSSMTEGIIILNENSNEQVMFWLVGSLSSMKWDEILTILPWLIGALIVTIFIGRQLTIMELGDD 234
Cdd:cd06550    81 LSPSKLILIGIVLSAFFSAGVILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDED 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 235 IAKGLGQNINKVRIIIGLLVIILTGMSVSVAGPIGFVGLIVPHIVKRYVSKNYLVMIPLTFIIGADLLLLSDVLSRLITy 314
Cdd:cd06550   161 LAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTLL- 239

                         250       260
                  ....*....|....*....|.
gi 2771934002 315 PYESPVGIVTSFVGALYFLFI 335
Cdd:cd06550   240 PSELPVGPVTALLGAPYFLYL 260
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 39-339 3.46e-93

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 280.03  E-value: 3.46e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002  39 MAIGSSKINFSDIVHYVTGHT-DTKATFLLHNVRMPRMIAGLFIGGALAVSGLLMQAMTRNPLASPKIFGVSSGASFFIV 117
Cdd:COG0609     2 LSLGAVPISLSDVLRALLGPDgDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 118 FVTIIIPSLEYYALYLG-VIGAFIGGLTVYTLSGATKGMTPIKLALAGMAIHLFFSSMTEGIIIL-NENSNEQVMFWLVG 195
Cdd:COG0609    82 LAIVLGGGLSALGLPLAaFLGALLAALLVYLLARRGGGLSPLRLVLAGVAVSALFSALTSLLLLLaDPEQLRSIVFWLMG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 196 SLSSMKWDEILTILPWLIGALIVTIFIGRQLTIMELGDDIAKGLGQNINKVRIIIGLLVIILTGMSVSVAGPIGFVGLIV 275
Cdd:COG0609   162 SLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLVV 241

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2771934002 276 PHIVKRYVSKNYLVMIPLTFIIGADLLLLSDVLSRLITYPYESPVGIVTSFVGALYFLFITIKG 339
Cdd:COG0609   242 PHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRR 305
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 31-338 5.68e-88

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 266.70  E-value: 5.68e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002  31 LFICIYLNMAIGSSKINFSDIVHYVTGHTDTKATFLLHNVRMPRMIAGLFIGGALAVSGLLMQAMTRNPLASPKIFGVSS 110
Cdd:pfam01032   2 LLLLILLSLFIGAVKISPSDVFSALLGGDDSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 111 GASFFIVFVTIIIPSLEYYAL-YLGVIGAFIGGLTVYTLSGATKGMTPIKLALAGMAIHLFFSSMTEGIIIL-NENSNEQ 188
Cdd:pfam01032  82 GAALGAVLAILLGGSLSLFALpLAAFIGALLAALLVYFLSRGRGGASPLRLILAGIAVSALLSALTSLLLLLlNPEALQS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 189 VMFWLVGSLSSMKWDEILTILPWLIGALIVTIFIGRQLTIMELGDDIAKGLGQNINKVRIIIGLLVIILTGMSVSVAGPI 268
Cdd:pfam01032 162 ILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGPI 241

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 269 GFVGLIVPHIVKRYVSKNYLVMIPLTFIIGADLLLLSDVLSRLITYPYESPVGIVTSFVGALYFLFITIK 338
Cdd:pfam01032 242 GFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
FepG COG4779
ABC-type enterobactin transport system, permease component [Inorganic ion transport and ...
 16-342 1.33e-65

ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443810  Cd Length: 344  Bit Score: 210.36  E-value: 1.33e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002  16 RKRRTTLTYIVSLCFLFICIYLNMAIGSSKINFSDIVHYVTGHTDTKATFLLHNVRMPRMIAGLFIGGALAVSGLLMQAM 95
Cdd:COG4779    18 LRRRALLVTLVLLLLLLALAVLALTLGDYPLSPGDVLRALLGEGDPGASFVVLELRLPRALAALLVGAALGLSGAIFQSL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002  96 TRNPLASPKIFGVSSGASFFIVFVTIIIPSLEYYALYLGVIGAFIGGLTVYTLSGaTKGMTPIKLALAGMAIHLFFSSMT 175
Cdd:COG4779    98 TRNPLASPDIIGITAGASAGAVAAIVVLGGSGLAVALGALAGGLATALLVYLLAW-RGGVSGYRLILVGIGVSAMLTAVN 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 176 EGIII-LNENSNEQVMFWLVGSLSSMKWDEILTILPWLIGALIVTIFIGRQLTIMELGDDIAKGLGQNINKVRIIIGLLV 254
Cdd:COG4779   177 SYLLTrADLEDAQSAAVWLTGSLNGRTWEDVLPLAVALAVLLPLALALARRLRLLELGDDTAAALGVRVERTRLLLLLVA 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 255 IILTGMSVSVAGPIGFVGLIVPHIVKRYVSKNYLVMIPlTFIIGADLLLLSDVLSRLITYPYESPVGIVTSFVGALYFLF 334
Cdd:COG4779   257 VALAAVATAAAGPIAFVALAAPQIARRLTRSPGPPLLP-SALVGALLLLAADLVAQHLLAPVQLPVGVVTGALGGPYLLW 335


                  ....*...
gi 2771934002 335 ITIKGVKR 342
Cdd:COG4779   336 LLIRENRR 343
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
66-329 1.58e-64

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 215.86  E-value: 1.58e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002  66 LLHNVRMPRMIAGLFIGGALAVSGLLMQAMTRNPLASPKIFGVSSGASFFIVFVTIIIPSL-EYYALYLGVIGAFIGGLT 144
Cdd:PRK10577   57 LLHYSRLPRLAIALLVGAALGLAGALLQQVLRNPLASPTTLGVAAGAQLALVLATLFAPALlALASQLAAFAGGLLAAAL 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 145 VYTLSGAtKGMTPIKLALAGMAIHLFFSSMTEGIIILNENSNEQVMFWLVGSLSSMKWDEILTILPWLIGALIVTIFIGR 224
Cdd:PRK10577  137 VFALAGG-KRLSPLRLVLAGMVVSLYLGALTTLLLLFNEQYLQGLFLWGAGSLAQNDWSGVQRLLPRLLVGLLLLLLLAR 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 225 QLTIMELGDDIAKGLGQNINKVRIIIGLLVIILTGMSVSVAGPIGFVGLIVPHIVKRYVSKNYLVMIPLTFIIGADLLLL 304
Cdd:PRK10577  216 PLTLLGLGDDVARSLGLAVSLTRLAALALAVLLSAAVVSAVGPIGFIGLAAPNLARLLGARRLRARLPLSPLIGALLLLL 295

                         250       260
                  ....*....|....*....|....*..
gi 2771934002 305 SDVLSRLITYPYES--PVGIVTSFVGA 329
Cdd:PRK10577  296 TDQLVRLLAGVGGEllPTGAVTALIGA 322
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
55-335 1.29e-56

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 186.82  E-value: 1.29e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002  55 VTGHTDTKATFLLHNVRMPRMIAGLFIGGALAVSGLLMQAMTRNPLASPKIFGVSSGASFFIVFVTIIIPS-LEYYALYL 133
Cdd:PRK11228   35 LPGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGALLQTLTHNPLASPSLLGINSGAALAMALTSALSPTpFAGYSLAF 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 134 -GVIGAFIGGLTVYTLSGATKGMTPI-KLALAGMAIHLFFSSMTEGIIILNENSNEQVMFWLVGSLSSMKWDEILTILPW 211
Cdd:PRK11228  115 iAACGGGLSWLLVMTAGGGWRHTHDRnRLILAGIALSALCMALTRITLLLAEDHAYGIFYWLAGGVSHARWQEVWQLLPF 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 212 LIGALIVTIFIGRQLTIMELGDDIAKGLGQNINKVRIIIGLLVIILTGMSVSVAGPIGFVGLIVPHIVKRYVSKNYLVMI 291
Cdd:PRK11228  195 VVTAVPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLLVGACVSVAGPVAFIGLLVPHLARFWIGYDQRNVL 274

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2771934002 292 PLTFIIGADLLLLSDVLSRLITYPYESPVGIVTSFVGALYFLFI 335
Cdd:PRK11228  275 PMSMLLGATLMLLADLLARALAFPGELPAGAVLALIGAPCFVWL 318
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
19-338 1.69e-55

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 183.71  E-value: 1.69e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002  19 RTTLTYIVSLCFLFICIYLNMAIGSSKINFSDIVHyvTGHTDTKATFLLHNVRMPRMIAGLFIGGALAVSGLLMQAMTRN 98
Cdd:PRK09777    1 MKIALVIFITLALAGCALLSLRMGVIPLPWRALLT--DWQAGDEHYYVLMEYRLPRLLLALFVGAALAVSGVLVQGIVRN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002  99 PLASPKIFGVSSGASFFIVFVTIIIPSLEYYALYLGvigAFIGGLTVYTLSGATKGM-TPIKLALAGMAIHLFFSSMTEG 177
Cdd:PRK09777   79 PLASPDILGVNHAASLASVGALLLFPSLPVMWLPLL---AFIGGMAGLILLKMLAGThQPMKLALTGVALSALWASLTDY 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 178 IIILNENSNEQVMFWLVGSLSSMKWDEILTILPWLIGALIVTIFIGRQLTIMELGDDIAKGLGQNINKVRIIIGLLVIIL 257
Cdd:PRK09777  156 LMLSRPQDINNALLWLTGSLWGRDWSFVKVALPWLILLLPLSLSFCRDLDLLALGDARATTLGVSVPHTQFWALLLAVAL 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 258 TGMSVSVAGPIGFVGLIVPHIVKRYVSKNYLVMIPLTFIIGADLLLLSDVLSRLITYPYESPVGIVTSFVGALYFLFITI 337
Cdd:PRK09777  236 TATGVAACGPISFIGLVVPHLMRSLVGGRHRRLLPVSALTGALLLLLADLLARIIHPPLELPAGVLTAIIGAPWFFWLLV 315


                  .
gi 2771934002 338 K 338
Cdd:PRK09777  316 R 316
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
71-342 1.80e-55

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 191.59  E-value: 1.80e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002  71 RMPRMIAGLFIGGALAVSGLLMQAMTRNPLASPKIFGVSSGASFFIVFVTIIIPSLEYYALYL-GVIGAFIGGLTVYTLS 149
Cdd:PRK10577  397 RLPRLLAALLAGAMLAVAGTLLQRLTRNPLASPEVLGISSGAGLGVVLALFLVPGAGFGWLLAaALLGALAALALILLLA 476

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 150 GATkGMTPIKLALAGMAIHLFFSSMTeGIIILNENSN-EQVMFWLVGSLSSMKWDEILTILPWLIGALIVTIFIGRQLTI 228
Cdd:PRK10577  477 RRG-GFAPERLLLTGIALSALFTALI-QLLLASGDPRaAQLLTWLSGSTYGVTWAQALPLLIVAVLLLALALLLRRWLDL 554

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 229 MELGDDIAKGLGQNINKVRIIIGLLVIILTGMSVSVAGPIGFVGLIVPHIVKRYVSKNYLVMIPLTFIIGADLLLLSDVL 308
Cdd:PRK10577  555 LPLGDDTARALGLPVTRARLALLLLAALLTAAATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALLMVLADWL 634

                         250       260       270
                  ....*....|....*....|....*....|....
gi 2771934002 309 SRLITYPYESPVGIVTSFVGALYFLFITIKGVKR 342
Cdd:PRK10577  635 GRTLLFPYQIPAGLLAALIGAPYFLWLLRRSRRR 668
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 75-335 1.90e-52

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 173.90  E-value: 1.90e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002  75 MIAGLFIGGALAVSGLLMQAMTRNPLASPKIFGVSSGASFFIVFVTIIIPSLEYYALYLGVIGAFIGGLTVYTLSGATKG 154
Cdd:cd06550     1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLASRGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 155 MTPIKLALAGMAIHLFFSSMTEGIIILNENSNEQVMFWLVGSLSSMKWDEILTILPWLIGALIVTIFIGRQLTIMELGDD 234
Cdd:cd06550    81 LSPSKLILIGIVLSAFFSAGVILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDED 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 235 IAKGLGQNINKVRIIIGLLVIILTGMSVSVAGPIGFVGLIVPHIVKRYVSKNYLVMIPLTFIIGADLLLLSDVLSRLITy 314
Cdd:cd06550   161 LAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTLL- 239

                         250       260
                  ....*....|....*....|.
gi 2771934002 315 PYESPVGIVTSFVGALYFLFI 335
Cdd:cd06550   240 PSELPVGPVTALLGAPYFLYL 260
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
27-335 5.53e-45

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 156.79  E-value: 5.53e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002  27 SLCFLFICIYLNMAIGSSKINFSDIVHYVTGHTDTKATFLLHNVRMPRMIAGLFIGGALAVSGLLMQAMTRNPLASPKIF 106
Cdd:PRK10441   16 LLLLLIIATALSLLIGAKSLPASVVLEALSGTCQSADCTIVLDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 107 GVSSGASFFIVF-VTIIIPSLEYYALYLGVIGAFIGGLTVYtLSGATKG--MTPIKLALAGMAIHLFFSSMTEGIIILNE 183
Cdd:PRK10441   96 GVNAGASFAIVLgAALFGYSSAQEQLAMAFAGALVASLIVA-FTGSQGGgqLSPVRLTLAGVALAAVLEGLTSGIALLNP 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 184 NSNEQVMFWLVGSLSSMKWDEILTILPWLIGALIVTIFIGRQLTIMELGDDIAKGLGQNINKVRIIIGLLVIILTGMSVS 263
Cdd:PRK10441  175 DVYDQLRFWQAGSLDIRNLHTLKVVLIPVLIAGATALLLSRALNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSATA 254

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2771934002 264 VAGPIGFVGLIVPHIVKRYVSKNYLVMIPLTFIIGADLLLLSDVLSRLITyPYESPVGIVTSFVGALYFLFI 335
Cdd:PRK10441  255 VVGPIAFIGLMMPHMARWLVGADHRWSLPVTLLATPALLLFADIIGRLLV-PGELRVSVVSAFIGAPVLIFL 325
btuC PRK09535
cobalamin ABC transporter permease BtuC;
70-335 1.49e-42

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 151.06  E-value: 1.49e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002  70 VRMPRMIAGLFIGGALAVSGLLMQAMTRNPLASPKIFGVSSGASF----FIVFVTIIIPSLEYYALylgvIGAFIGGLTV 145
Cdd:PRK09535   94 IRLPRILLAATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVgavaAIVLPLAVPFGLQAAAF----AGALVAAFGV 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 146 YTLsgATK-GMTPI-KLALAGMAIHLFFSSMTEGIIILNENSNEQVMFWLVGSLSSMKWDEILTILPWLIGALIVTIFIG 223
Cdd:PRK09535  170 YAI--ATEnGRTPVaTLLLAGVAVQTFLGAVISYLLLHSGESLRRAVYWLMGHLHGSTWSDVEVALPVVVVGFVVLLAYA 247

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 224 RQLTIMELGDDIAKGLGQNINKVRIIIGLLVIILTGMSVSVAGPIGFVGLIVPHIVKRYVSKNYLVMIPLTFIIGADLLL 303
Cdd:PRK09535  248 RDLNVLLLGEEDAHTLGIEVERTKRLLLALASVVTAAAVAVAGVIGFVGLIVPHVMRLLVGPDHRILLPTSALAGASFLV 327

                         250       260       270
                  ....*....|....*....|....*....|..
gi 2771934002 304 LSDVLSRliTYPYESPVGIVTSFVGALYFLFI 335
Cdd:PRK09535  328 ATDTVAR--SGPAEVPVGIVTAALGAPFFLYL 357
BtuC COG4139
ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and ...
 10-341 1.01e-41

ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and metabolism];


Pssm-ID: 443314  Cd Length: 327  Bit Score: 148.08  E-value: 1.01e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002  10 SAIDHKRKRRTTLTYIVSLCFLFICIYLNMAIGSSKINFSDIvhyvtghTDTKATFLLHNVRMPRMIAGLFIGGALAVSG 89
Cdd:COG4139     1 MQLPQRQRRRDRRWLLLLLLLLLLLFVLSLCAGEVWIPPTQW-------LSEAWQLFVWQLRLPRTLAAVLVGASLAVSG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002  90 LLMQAMTRNPLASPKIFGVSSGASFFIVFVTIIIPSLeyYALYLGVIGAFIGGLTVYT--LSGATKGMTPIKLALAGMAI 167
Cdd:COG4139    74 AVMQALFENPLAEPGLLGISNGAGVGLVLVVLLGGGL--LPPWLLSLAAIAGALLVTLllLAFARRRLSNARLLLIGVAL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 168 HLFFSS-MTEGIIILNENSNEQVMFWLVGSLSSMKWDEiLTILPWLIGALIVTIFIGRQLTIMELGDDIAKGLGQNINKV 246
Cdd:COG4139   152 GIICSAiMTWAVYFSSSLDLRQLMYWMMGSFGGVDWRQ-LWLLLALLPVLLWLCLQGKPLNLLLLGENQARQLGLSVHRW 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 247 RIIIGLLVIILTGMSVSVAGPIGFVGLIVPHIVKRYVSKNYLVMIPLTFIIGADLLLLSDVLSRLITYPYESPVGIVTSF 326
Cdd:COG4139   231 RNLLVLATGLLVGVSVALAGPIGFVGLVVPHLLRLLGTTDHRFLLPACALAGAALLLLADIIARLALSSAELPIGVVTAT 310

                         330
                  ....*....|....*
gi 2771934002 327 VGALYFLFITIKGVK 341
Cdd:COG4139   311 LGAPVFIWLLLRRRK 325
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 9-338 1.23e-34

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 129.31  E-value: 1.23e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002   9 QSAIDHKRKRRTTLTYIVSLCFLFICIyLNMAIGsskinfsDIVHYVTGHTDTKATFLLHNVRMPRMIAGLFIGGALAVS 88
Cdd:PRK03784    4 LTLARQQQRRNRRWLLGLSVLLLLALL-LSLCAG-------EQWISPGDWLSPRGELFVWQLRLPRTLAVLLVGAALAVS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002  89 GLLMQAMTRNPLASPKIFGVSSGASFFIVFVTIIIPSLeyYALYLGVIGAFIGGL--TVYTLSGATKG-MTPIKLALAGM 165
Cdd:PRK03784   76 GAVMQALFENPLAEPGLLGVSNGAGVALVAAVLLGQGL--LPPWALSLCAIAGALliTLILLRFARRHrLSTSRLLLAGV 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 166 AIHLFFSS-MTEGIIILNENSNEQVMFWLVGSLSSMKWDEiltilPWLIGALIVTIFI----GRQLTIMELGDDIAKGLG 240
Cdd:PRK03784  154 ALGIICSAlMTWAVYFSTSLDLRQLMYWMMGGFGGVDWRQ-----SWLMLALLPVLIWlccqGRPLNMLALGEISARQLG 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 241 QNINKVRIIIGLLVIILTGMSVSVAGPIGFVGLIVPHIVKRYVSKNYLVMIPLTFIIGADLLLLSDVLSRLITYPYESPV 320
Cdd:PRK03784  229 LPLWFWRNLLVLATGWLVGVSVALAGAIGFIGLVIPHILRLCGLTDHRVLLPGCALAGASLLLLADIVARLALASAELPI 308

                         330
                  ....*....|....*...
gi 2771934002 321 GIVTSFVGALYFLFITIK 338
Cdd:PRK03784  309 GVVTATLGAPVFIWLLLR 326
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
18-338 5.12e-31

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 119.43  E-value: 5.12e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002  18 RRTTLTYIVSLCFLFICIYLNMAIGSSKINFSDIVHYVTGHTDTKATFLLHNVRMPRMIAGLFIGGALAVSGLLMQAMTR 97
Cdd:PRK10440    6 RRLLITCLLLLAACVAAGLWGLRSGAVTLETSQVFAALMGDAPRSMTMVVTEWRLPRVLMALLIGAALGVSGAIFQSLMR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002  98 NPLASPKIFGVSSGAsFFIVFVTIIIPSLEYYALYLGVI-GAFIGGLTVYTLSgATKGMTPIKLALAGMAIHLFFSSMTE 176
Cdd:PRK10440   86 NPLGSPDVMGFNTGA-WSGVLVAMVLFGQDLTAIALAAMaGGIVTSLLVWLLA-WRNGIDTFRLIIIGIGVRAMLVAFNT 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 177 GIIIlnENSNEQVM---FWLVGSLSSMKWDEILTILPWLIGALIVTIFIGRQLTIMELGDDIAKGLGQNINKVRIIIGLL 253
Cdd:PRK10440  164 WLLL--KASLETALtagLWNAGSLNGLTWAKTSPSAPIIILMLIAAALLVRRMRLLEMGDDTACALGVSVERSRLLLMLV 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2771934002 254 VIILTGMSVSVAGPIGFVGLIVPHIVKRyVSKNYLVMIPLTFIIGADLLLLSDVLSRLITYPYESPVGIVTSFVGALYFL 333
Cdd:PRK10440  242 AVVLTAAATALAGPISFIALVAPHIARR-LSGTARWGLTQAALCGALLLLAADLCAQQLFMPYQLPVGVVTVSLGGIYLI 320


                  ....*
gi 2771934002 334 FITIK 338
Cdd:PRK10440  321 VLLIQ 325
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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