|
Name |
Accession |
Description |
Interval |
E-value |
| PRK01584 |
PRK01584 |
alanyl-tRNA synthetase; Provisional |
1-577 |
0e+00 |
|
alanyl-tRNA synthetase; Provisional
Pssm-ID: 234962 [Multi-domain] Cd Length: 594 Bit Score: 527.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 1 MNHFELRQRFSSFWESKDHKWVPPIPLIPVNDSTTLFTSSGMQQLVPYLLGQEHPLGKRLYNIQPCFRSQDIEDIGDNRH 80
Cdd:PRK01584 1 MTLDELRKKYIDFFKSKGHVEIAGKSLIPENDPTVLFTTAGMHPLVPYLLGEPHPSGTRLVDVQKCLRTGDIDEVGDLSH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 81 TTFFEMMGNWSLGDYFKTEQLNWVFEFLVQE--LGLNPNNLYVTVFSGWQKLPEDKESILIWKKIfkqyGIQAEvgeRIF 158
Cdd:PRK01584 81 LTFFEMLGNWSLGAYFKEESIKYSFEFLTSPdyLNIPKDKLYVTVFEGDEEIPRDEETASVWESL----GIPKD---RIF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 159 KYPAEKNWWSrsgvpenmPVNE--PGGPDSEIFYKFDSvehnKKFGDYCHPNCDCGRFIEIGNSVFMQYKKTESG-FVEL 235
Cdd:PRK01584 154 YLSREHNWWG--------PVGEtgPCGPDTEIFVDTGK----PKCSVNCRPTCSCGKYFEIWNNVFMQYNKDEDGnYEEL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 236 PNKNVDFGGGLERILAACCNNPDVFLTDLYKPLINQLEVDLGFNYS-NSDNKKSLRIIADHLKAAVFLIKD--GVVPSNK 312
Cdd:PRK01584 222 KRKCVDTGMGIERTIAFLQGKSSVYDTEAFTPIIKRIEKISGKIYGqNEEDDRSIRIIADHIRAACFILGDpfVVLPSNV 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 313 EQGYFLRRLLRRlAVKiYQAKDEVSFEYVKKSISVIIKMYHDVYFKDNNAED-ISGIVAQEFAKFGQTIKQGFKK-IKDI 390
Cdd:PRK01584 302 GQGYVLRRLIRR-SIR-HAKKLGIESHFLADLVDSVEEIYGSFYPELTEKKDfIKEELNKEEEKFFKTLRKGEQEfIKLI 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 391 DKISPK------LAFDLYQSYGFPFEITKEIFEQRGQSLSQEEFNNYVKEHKKISRRSMFKKFKGGLADKEEQTIKYHTA 464
Cdd:PRK01584 380 PNLGSSkiipgdIAFKLYDTYGFPYEITEELASEYGFTVDREGFDEHFKKHQKVSKKGADKVFKGGLADHSYETTKLHTA 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 465 THLIHQAITDLLGETVRQEGSNITAERLRFDFYSNQKPDDNFKDKLEKIVNEKIKQGLPVRYEIMPKEKAYKIGAKSFFK 544
Cdd:PRK01584 460 THLLHKALRLVLGDHVRQKGSNITAERLRFDFSHPEKMTDDEIKKVEDIVNLQIKNDLSVKKEVMSLEEAREKGAMALFG 539
|
570 580 590
....*....|....*....|....*....|...
gi 2315491310 545 EKYPDKVKVYFIGEYSKEFCGGPHVANTSEIGS 577
Cdd:PRK01584 540 EKYEDIVKVYEIDGFSKEVCGGPHVENTGELGT 572
|
|
| AlaS |
COG0013 |
Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Alanyl-tRNA ... |
1-576 |
1.56e-163 |
|
Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Alanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439784 [Multi-domain] Cd Length: 880 Bit Score: 489.18 E-value: 1.56e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 1 MNHFELRQRFSSFWESKDHKWVPPIPLIPVNDSTTLFTSSGMQQLVPYLLGQEHPLGKRLYNIQPCFR----SQDIEDIG 76
Cdd:COG0013 2 MTSAEIRQKFLDFFESKGHTIVPSSSLVPKNDPTLLFTNAGMVQFKPYFLGQEKPPYPRATTSQKCVRtggkHNDLENVG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 77 -DNRHTTFFEMMGNWSLGDYFKTEQLNWVFEFLVQELGLNPNNLYVTVFsgwqklPEDKESILIWKKIFkqyGIQAevgE 155
Cdd:COG0013 82 yTARHHTFFEMLGNFSFGDYFKEEAIAWAWELLTEVLGLPKERLWVTVY------EDDDEAYDIWKKEI---GVPE---E 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 156 RIFKYPAEKNWWSrsgvpenMPVNEPGGPDSEIFYkfDsveHNKKFGD--YCHPNCDCGRFIEIGNSVFMQYKKTESG-F 232
Cdd:COG0013 150 RIIRLGKKDNFWE-------MGDTGPCGPCSEIFY--D---RGPEYGGgpPGSPGEDGDRYIEIWNLVFMQFNRDEDGtL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 233 VELPNKNVDFGGGLERILAACCNNPDVFLTDLYKPLINQLEVDLGFNY-SNSDNKKSLRIIADHLKAAVFLIKDGVVPSN 311
Cdd:COG0013 218 TPLPKKNIDTGMGLERIAAVLQGVHSNYETDLFRPLIEAAAELTGVKYgADEEDDVSLRVIADHIRAVAFLIADGVLPSN 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 312 KEQGYflrrllrrlaV--KI--------YQ--AKDEVSFEYVKksisVIIKMYHDVY--FKDnNAEDISGIVAQEFAKFG 377
Cdd:COG0013 298 EGRGY----------VlrRIlrravrhgRLlgIKEPFLYKLVP----VVVEEMGDAYpeLKE-KQELIEKVLKAEEERFL 362
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 378 QTIKQGFKKIKDI---------DKISPKLAFDLYQSYGFPFEITKEIFEQRGQSLSQEEFNNYVKEHKKISRRSM-FKK- 446
Cdd:COG0013 363 RTLERGLKLLDEAiaklkaaggKVLSGEDAFKLYDTYGFPLDLTEEIARERGLTVDEEGFEAAMEEQRERARAAAkFSGd 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 447 ----------------------------------FKGG-----LADKEE----------------Q-------------- 457
Cdd:COG0013 443 aavdgvwrelleeggptefvgydtleaeakvlalVKDGelvdsAKAGEEvevvldrtpfyaesggQvgdtgtiegdggvf 522
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 458 ----TIKY-------------------------------------HTATHLIHQAITDLLGETVRQEGSNITAERLRFDF 496
Cdd:COG0013 523 evtdTQKPpgglivhigkveegelkvgdtvtaqvdaerrraiarnHSATHLLHAALREVLGEHVTQAGSLVAPDRLRFDF 602
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 497 YSNQKPDDNFKDKLEKIVNEKIKQGLPVRYEIMPKEKAYKIGAKSFFKEKYPDKVKVYFIGEYSKEFCGGPHVANTSEIG 576
Cdd:COG0013 603 SHFEALTPEELAEIEDLVNEKIRENLPVETREMPLDEAKALGAMALFGEKYGDEVRVVSIGDFSRELCGGTHVSRTGDIG 682
|
|
| alaS |
TIGR00344 |
alanine--tRNA ligase; The model describes alanine--tRNA ligase. This enzyme catalyzes the ... |
5-576 |
5.28e-122 |
|
alanine--tRNA ligase; The model describes alanine--tRNA ligase. This enzyme catalyzes the reaction (tRNAala + L-alanine + ATP = L-alanyl-tRNAala + pyrophosphate + AMP). [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273026 [Multi-domain] Cd Length: 845 Bit Score: 380.57 E-value: 5.28e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 5 ELRQRFSSFWESKDHKWVPPIPLIPVNDSTTLFTSSGMQQLVPYLLGQEHPLGKRLYNIQPCFRSQDIEDIG-DNRHTTF 83
Cdd:TIGR00344 1 EIRQTFLDFFKEKGHQVIPSAPLVPRNDPTLLLTNAGMAQFKPIFTGIVKPPSNRLTNAQPCIRLNDLENVGrTARHHTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 84 FEMMGNWSLGDYFKTEQLNWVFEFLVQELGLNPNNLYVTVFsgwqklPEDKESILIWKKIFKqygiqaeVGERIFKYPAE 163
Cdd:TIGR00344 81 FEMLGNFSFGDYFKEEAIAFAWELLTEVLGLDKERLYVTVY------EDDEEAYKIWEKIGI-------PADRIIKCDAK 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 164 KNWWSRSGVPEnmpvnepgGPDSEIFYKFDSvehnkkfGDYCHPNCDCGRFIEIGNSVFMQYKKTESG-FVELPNKNVDF 242
Cdd:TIGR00344 148 DNFWDMGDGPC--------GPCTEIYYDFVG-------GKPGEPLEENDRYLEVWNLVFMQFNRDPDGnYTPLPKKNIDT 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 243 GGGLERILAACCNNPDVFLTDLYKPLINQLEVDLGFNY-SNS---------DNKKSLRIIADHLKAAVFLIKDGVVPSNK 312
Cdd:TIGR00344 213 GMGLERFVAVLQGVPTNYDTDIFLPLIEKIEEITGVKYdSNNagimdekrvEDLRSLRVIADHTRAIAFMLADGVVPSNE 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 313 EQGYFLRRLLRRLAvkIYQAKDEVSFEYVKKSISVIIKMYHDVY--FKDNNaEDISGIVAQEFAKFGQTIKQGFK----- 385
Cdd:TIGR00344 293 GRGYVLRRLIRRAL--RHGKKLGLKEAFLYKLVPTLIEVLGDYYpeLKEKQ-EFVEQILELEEERFAKTLERGLRlfekl 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 386 -KIKDIDKISPKLAFDLYQSYGFPFEITKEIFEQRGQSLSQEEFNNYVKEHKKISR-RSMFKK-------------FKG- 449
Cdd:TIGR00344 370 lKKTGKKELDGEDAFKLYDTYGFPVELTKEIAEERGLTVDMPGFEALMAEQRERSKqNSQFQEqeialvnvypateFLGy 449
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 450 ----------GLADKE----------------EQTIKY------------------------------------------ 461
Cdd:TIGR00344 450 ddlefeakviGLFDDGylveqalagqsvyvilDQTPFYaesggqigdtgyliandgkfrvvdvqkpngvvfhfgeveggs 529
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 462 ----------------------HTATHLIHQAITDLLGETVRQEGSNITAERLRFDFYSNQKPDDNFKDKLEKIVNEKIK 519
Cdd:TIGR00344 530 lkvgdkviavidekrrfrimrnHSATHLLHAALQKVLGNHVWQAGSLVSFKKLRFDFSHFRALTREELEEIEDLANEQIL 609
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*....
gi 2315491310 520 QGLPVRYEIMPKEKAYKIGAKSFFKEKYP--DKVKVYFIGEYSKEFCGGPHVANTSEIG 576
Cdd:TIGR00344 610 ANIPIKVIFMDLDEAKRKGAFALFGEKYVpgEKVRVVSVGDFSVELCGGTHVRNTGEIG 668
|
|
| tRNA-synt_2c |
pfam01411 |
tRNA synthetases class II (A); Other tRNA synthetase sub-families are too dissimilar to be ... |
5-498 |
1.71e-96 |
|
tRNA synthetases class II (A); Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only alanyl-tRNA synthetases.
Pssm-ID: 279719 [Multi-domain] Cd Length: 548 Bit Score: 305.36 E-value: 1.71e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 5 ELRQRFSSFWESKDHKWVPPIPLIPVNDSTTLFTSSGMQQLVPYLLGQEH-PLGKRLYNIQPCFRSQDIEDIG-DNRHTT 82
Cdd:pfam01411 1 EIRQTFLDFFEKKGHTRVPSSPVVPRNDPTLLFTNAGMNQFKPIFLGGVAkPPYNRATNSQKCIRAGDLENVGrTGRHHT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 83 FFEMMGNWSLGDYFKTEQLNWVFEFLVQELGLNPNNLYVTVFsgwqklPEDKESILIWKKIfkqYGIQAevgERIFKYPA 162
Cdd:pfam01411 81 FFEMLGNFSFGDYFKEEAIEYAWELLTKELGLPPERLYVTVF------EWDDEAGPIWEKI---VGGPE---ERILRFGD 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 163 EKNWWSrsgvpenMPVNEPGGPDSEIFYkfdsvEHNKKFGDYCH---PNCDCGRFIEIGNSVFMQYKKTESGFVE-LPNK 238
Cdd:pfam01411 149 KDNFWE-------MGDTGPCGPCSEIDY-----DRGEEIGGWDSggtPTADDDRFLEIWNLVFMQFNRENDGTLKpLPKK 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 239 NVDFGGGLERILAACCNNPDVFLTDLYKPLINQLEVDLGFNYSNSDNKK-SLRIIADHLKAAVFLIKDGVVPSNKEQGYF 317
Cdd:pfam01411 217 SIDTGMGLERLVAVLQDVRSNYDTDVFIPVIELIEEISGARYYTVDETDeAYRVIADHTRALTFALADGVVPSNEGRGYV 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 318 lrrllrrlAVKI------YQAKDEVSFEYVKKSISVIIKMYHDVY--FKDNNaEDISGIVAQEFAKFGQTIKQGFKKI-- 387
Cdd:pfam01411 297 --------LRRIlrravrHAKKLGLKEPFLYDLVPTVVEVLGDAYpeLKEDE-DFIQEILELEEERFAKTLERGLRLLer 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 388 ------KDIDKISPKLAFDLYQSYGFPFEITKEIFEQRGQSLSQEEFNNYVKEHKKISRRSMfkkfKGGLADKEEQTIKY 461
Cdd:pfam01411 368 liaklkKGKKTLPGEDAFKLYDTYGFPVDLTKEIAEERGLKVDMPGFEYAMVEQRERSKQAV----KEKGEKLDVSALKE 443
|
490 500 510
....*....|....*....|....*....|....*..
gi 2315491310 462 HTAThlihqaiTDLLGETVRQEGSNITAerLRFDFYS 498
Cdd:pfam01411 444 LPAT-------TEFLGYDDLESEAKILA--LPKDGEF 471
|
|
| AlaRS_core |
cd00673 |
Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is ... |
5-252 |
3.34e-79 |
|
Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. Class II assignment is based upon its predicted structure and the presence of three characteristic sequence motifs.
Pssm-ID: 238360 [Multi-domain] Cd Length: 232 Bit Score: 249.58 E-value: 3.34e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 5 ELRQRFSSFWESKDHKWVPPIPLIPVNDSTTLFTSSGMQQLVPYLLGQEHPLGKRLYNIQPCFRSQDIEDIG-DNRHTTF 83
Cdd:cd00673 3 EIRETFLSFFEKKGHTRVPSSPVVPRDDPTLLFTNAGMNQFKPIFLGEVPPPANRLVNSQKCIRAGDIDNVGkTGRHHTF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 84 FEMMGNWSLGDYFKTEQLNWVFEFLVQELGLNPNNLYVTVFSGwqklPEDKESILIWKKIFkqygiqaeVGERIFKYPAE 163
Cdd:cd00673 83 FEMLGNFSFGDYFKEEAIAFAWELLTEVLGLPKDRLYVSVFEG----DDEEEAIWWWKIGL--------PGIRIERIGFK 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 164 KNWWSrsgvpenMPVNEPGGPDSEIFYkfdsvEHNKKFGDYCHPNCDCGRFIEIGNSVFMQYKKTESG-FVELPNKNVDF 242
Cdd:cd00673 151 DNFWE-------MGGNGPCGPCSEIFY-----DRGEERDAASLPNEDDDRYLEIWNLVFMQYNRDADGtYRPLPKKIVDT 218
|
250
....*....|
gi 2315491310 243 GGGLERILAA 252
Cdd:cd00673 219 GMGLERLVWV 228
|
|
| tRNA_SAD |
smart00863 |
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active form of ... |
551-576 |
2.30e-09 |
|
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active form of threonyl/alanyl tRNA synthetase is a dimer. Within the tRNA synthetase class II dimer, the bound tRNA interacts with both monomers making specific interactions with the catalytic domain, the C-terminal domain, and this SAD domain (the second additional domain). The second additional domain is comprised of a pair of perpendicularly orientated antiparallel beta sheets, of four and three strands, respectively, that surround a central alpha helix that forms the core of the domain.
Pssm-ID: 197931 [Multi-domain] Cd Length: 43 Bit Score: 53.15 E-value: 2.30e-09
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK01584 |
PRK01584 |
alanyl-tRNA synthetase; Provisional |
1-577 |
0e+00 |
|
alanyl-tRNA synthetase; Provisional
Pssm-ID: 234962 [Multi-domain] Cd Length: 594 Bit Score: 527.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 1 MNHFELRQRFSSFWESKDHKWVPPIPLIPVNDSTTLFTSSGMQQLVPYLLGQEHPLGKRLYNIQPCFRSQDIEDIGDNRH 80
Cdd:PRK01584 1 MTLDELRKKYIDFFKSKGHVEIAGKSLIPENDPTVLFTTAGMHPLVPYLLGEPHPSGTRLVDVQKCLRTGDIDEVGDLSH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 81 TTFFEMMGNWSLGDYFKTEQLNWVFEFLVQE--LGLNPNNLYVTVFSGWQKLPEDKESILIWKKIfkqyGIQAEvgeRIF 158
Cdd:PRK01584 81 LTFFEMLGNWSLGAYFKEESIKYSFEFLTSPdyLNIPKDKLYVTVFEGDEEIPRDEETASVWESL----GIPKD---RIF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 159 KYPAEKNWWSrsgvpenmPVNE--PGGPDSEIFYKFDSvehnKKFGDYCHPNCDCGRFIEIGNSVFMQYKKTESG-FVEL 235
Cdd:PRK01584 154 YLSREHNWWG--------PVGEtgPCGPDTEIFVDTGK----PKCSVNCRPTCSCGKYFEIWNNVFMQYNKDEDGnYEEL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 236 PNKNVDFGGGLERILAACCNNPDVFLTDLYKPLINQLEVDLGFNYS-NSDNKKSLRIIADHLKAAVFLIKD--GVVPSNK 312
Cdd:PRK01584 222 KRKCVDTGMGIERTIAFLQGKSSVYDTEAFTPIIKRIEKISGKIYGqNEEDDRSIRIIADHIRAACFILGDpfVVLPSNV 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 313 EQGYFLRRLLRRlAVKiYQAKDEVSFEYVKKSISVIIKMYHDVYFKDNNAED-ISGIVAQEFAKFGQTIKQGFKK-IKDI 390
Cdd:PRK01584 302 GQGYVLRRLIRR-SIR-HAKKLGIESHFLADLVDSVEEIYGSFYPELTEKKDfIKEELNKEEEKFFKTLRKGEQEfIKLI 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 391 DKISPK------LAFDLYQSYGFPFEITKEIFEQRGQSLSQEEFNNYVKEHKKISRRSMFKKFKGGLADKEEQTIKYHTA 464
Cdd:PRK01584 380 PNLGSSkiipgdIAFKLYDTYGFPYEITEELASEYGFTVDREGFDEHFKKHQKVSKKGADKVFKGGLADHSYETTKLHTA 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 465 THLIHQAITDLLGETVRQEGSNITAERLRFDFYSNQKPDDNFKDKLEKIVNEKIKQGLPVRYEIMPKEKAYKIGAKSFFK 544
Cdd:PRK01584 460 THLLHKALRLVLGDHVRQKGSNITAERLRFDFSHPEKMTDDEIKKVEDIVNLQIKNDLSVKKEVMSLEEAREKGAMALFG 539
|
570 580 590
....*....|....*....|....*....|...
gi 2315491310 545 EKYPDKVKVYFIGEYSKEFCGGPHVANTSEIGS 577
Cdd:PRK01584 540 EKYEDIVKVYEIDGFSKEVCGGPHVENTGELGT 572
|
|
| AlaS |
COG0013 |
Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Alanyl-tRNA ... |
1-576 |
1.56e-163 |
|
Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Alanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439784 [Multi-domain] Cd Length: 880 Bit Score: 489.18 E-value: 1.56e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 1 MNHFELRQRFSSFWESKDHKWVPPIPLIPVNDSTTLFTSSGMQQLVPYLLGQEHPLGKRLYNIQPCFR----SQDIEDIG 76
Cdd:COG0013 2 MTSAEIRQKFLDFFESKGHTIVPSSSLVPKNDPTLLFTNAGMVQFKPYFLGQEKPPYPRATTSQKCVRtggkHNDLENVG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 77 -DNRHTTFFEMMGNWSLGDYFKTEQLNWVFEFLVQELGLNPNNLYVTVFsgwqklPEDKESILIWKKIFkqyGIQAevgE 155
Cdd:COG0013 82 yTARHHTFFEMLGNFSFGDYFKEEAIAWAWELLTEVLGLPKERLWVTVY------EDDDEAYDIWKKEI---GVPE---E 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 156 RIFKYPAEKNWWSrsgvpenMPVNEPGGPDSEIFYkfDsveHNKKFGD--YCHPNCDCGRFIEIGNSVFMQYKKTESG-F 232
Cdd:COG0013 150 RIIRLGKKDNFWE-------MGDTGPCGPCSEIFY--D---RGPEYGGgpPGSPGEDGDRYIEIWNLVFMQFNRDEDGtL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 233 VELPNKNVDFGGGLERILAACCNNPDVFLTDLYKPLINQLEVDLGFNY-SNSDNKKSLRIIADHLKAAVFLIKDGVVPSN 311
Cdd:COG0013 218 TPLPKKNIDTGMGLERIAAVLQGVHSNYETDLFRPLIEAAAELTGVKYgADEEDDVSLRVIADHIRAVAFLIADGVLPSN 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 312 KEQGYflrrllrrlaV--KI--------YQ--AKDEVSFEYVKksisVIIKMYHDVY--FKDnNAEDISGIVAQEFAKFG 377
Cdd:COG0013 298 EGRGY----------VlrRIlrravrhgRLlgIKEPFLYKLVP----VVVEEMGDAYpeLKE-KQELIEKVLKAEEERFL 362
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 378 QTIKQGFKKIKDI---------DKISPKLAFDLYQSYGFPFEITKEIFEQRGQSLSQEEFNNYVKEHKKISRRSM-FKK- 446
Cdd:COG0013 363 RTLERGLKLLDEAiaklkaaggKVLSGEDAFKLYDTYGFPLDLTEEIARERGLTVDEEGFEAAMEEQRERARAAAkFSGd 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 447 ----------------------------------FKGG-----LADKEE----------------Q-------------- 457
Cdd:COG0013 443 aavdgvwrelleeggptefvgydtleaeakvlalVKDGelvdsAKAGEEvevvldrtpfyaesggQvgdtgtiegdggvf 522
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 458 ----TIKY-------------------------------------HTATHLIHQAITDLLGETVRQEGSNITAERLRFDF 496
Cdd:COG0013 523 evtdTQKPpgglivhigkveegelkvgdtvtaqvdaerrraiarnHSATHLLHAALREVLGEHVTQAGSLVAPDRLRFDF 602
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 497 YSNQKPDDNFKDKLEKIVNEKIKQGLPVRYEIMPKEKAYKIGAKSFFKEKYPDKVKVYFIGEYSKEFCGGPHVANTSEIG 576
Cdd:COG0013 603 SHFEALTPEELAEIEDLVNEKIRENLPVETREMPLDEAKALGAMALFGEKYGDEVRVVSIGDFSRELCGGTHVSRTGDIG 682
|
|
| alaS |
TIGR00344 |
alanine--tRNA ligase; The model describes alanine--tRNA ligase. This enzyme catalyzes the ... |
5-576 |
5.28e-122 |
|
alanine--tRNA ligase; The model describes alanine--tRNA ligase. This enzyme catalyzes the reaction (tRNAala + L-alanine + ATP = L-alanyl-tRNAala + pyrophosphate + AMP). [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273026 [Multi-domain] Cd Length: 845 Bit Score: 380.57 E-value: 5.28e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 5 ELRQRFSSFWESKDHKWVPPIPLIPVNDSTTLFTSSGMQQLVPYLLGQEHPLGKRLYNIQPCFRSQDIEDIG-DNRHTTF 83
Cdd:TIGR00344 1 EIRQTFLDFFKEKGHQVIPSAPLVPRNDPTLLLTNAGMAQFKPIFTGIVKPPSNRLTNAQPCIRLNDLENVGrTARHHTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 84 FEMMGNWSLGDYFKTEQLNWVFEFLVQELGLNPNNLYVTVFsgwqklPEDKESILIWKKIFKqygiqaeVGERIFKYPAE 163
Cdd:TIGR00344 81 FEMLGNFSFGDYFKEEAIAFAWELLTEVLGLDKERLYVTVY------EDDEEAYKIWEKIGI-------PADRIIKCDAK 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 164 KNWWSRSGVPEnmpvnepgGPDSEIFYKFDSvehnkkfGDYCHPNCDCGRFIEIGNSVFMQYKKTESG-FVELPNKNVDF 242
Cdd:TIGR00344 148 DNFWDMGDGPC--------GPCTEIYYDFVG-------GKPGEPLEENDRYLEVWNLVFMQFNRDPDGnYTPLPKKNIDT 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 243 GGGLERILAACCNNPDVFLTDLYKPLINQLEVDLGFNY-SNS---------DNKKSLRIIADHLKAAVFLIKDGVVPSNK 312
Cdd:TIGR00344 213 GMGLERFVAVLQGVPTNYDTDIFLPLIEKIEEITGVKYdSNNagimdekrvEDLRSLRVIADHTRAIAFMLADGVVPSNE 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 313 EQGYFLRRLLRRLAvkIYQAKDEVSFEYVKKSISVIIKMYHDVY--FKDNNaEDISGIVAQEFAKFGQTIKQGFK----- 385
Cdd:TIGR00344 293 GRGYVLRRLIRRAL--RHGKKLGLKEAFLYKLVPTLIEVLGDYYpeLKEKQ-EFVEQILELEEERFAKTLERGLRlfekl 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 386 -KIKDIDKISPKLAFDLYQSYGFPFEITKEIFEQRGQSLSQEEFNNYVKEHKKISR-RSMFKK-------------FKG- 449
Cdd:TIGR00344 370 lKKTGKKELDGEDAFKLYDTYGFPVELTKEIAEERGLTVDMPGFEALMAEQRERSKqNSQFQEqeialvnvypateFLGy 449
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 450 ----------GLADKE----------------EQTIKY------------------------------------------ 461
Cdd:TIGR00344 450 ddlefeakviGLFDDGylveqalagqsvyvilDQTPFYaesggqigdtgyliandgkfrvvdvqkpngvvfhfgeveggs 529
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 462 ----------------------HTATHLIHQAITDLLGETVRQEGSNITAERLRFDFYSNQKPDDNFKDKLEKIVNEKIK 519
Cdd:TIGR00344 530 lkvgdkviavidekrrfrimrnHSATHLLHAALQKVLGNHVWQAGSLVSFKKLRFDFSHFRALTREELEEIEDLANEQIL 609
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*....
gi 2315491310 520 QGLPVRYEIMPKEKAYKIGAKSFFKEKYP--DKVKVYFIGEYSKEFCGGPHVANTSEIG 576
Cdd:TIGR00344 610 ANIPIKVIFMDLDEAKRKGAFALFGEKYVpgEKVRVVSVGDFSVELCGGTHVRNTGEIG 668
|
|
| PLN02900 |
PLN02900 |
alanyl-tRNA synthetase |
5-576 |
1.50e-120 |
|
alanyl-tRNA synthetase
Pssm-ID: 215487 [Multi-domain] Cd Length: 936 Bit Score: 378.97 E-value: 1.50e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 5 ELRQRFSSFWESKDHKWVPPIPLIPVNDSTTLFTSSGMQQLVPYLLGQEHPLG-----KRLYNIQPCFRSQ----DIEDI 75
Cdd:PLN02900 15 RIRRTFLSFFESKGHTFLPSSPLVPVDDPTLLFTNAGMNQFKPIFLGTADPNTplrklPRATNTQKCIRAGgkhnDLDDV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 76 G-DNRHTTFFEMMGNWSLGDYFKTEQLNWVFEFLVQELGLNPNNLYVTVFSGWQKLPEDKESILIWKKIFKQygiqaevg 154
Cdd:PLN02900 95 GkDTYHHTFFEMLGNWSFGDYFKKEAIGWAWELLTKVYGLPADRLYATYFGGDEKQAPDDEARAIWLDYLPE-------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 155 ERIFKYPAEKNWWSrsgvpenMPVNEPGGPDSEIFYKFdsvehnkkfgdycHP--------NCDCGRFIEIGNSVFMQYK 226
Cdd:PLN02900 167 ERVLPFGCKDNFWE-------MGDTGPCGPCSEIHYDR-------------IGerdaadlvNNDDPRFIEIWNLVFIQFN 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 227 KTESGFVE-LPNKNVDFGGGLER---ILAACCNNPDvflTDLYKPLINQL-EVDLGFNYSN------SDNKK-SLRIIAD 294
Cdd:PLN02900 227 READGSLKpLPAKHVDTGMGLERlasILQNKPSNYD---TDLFMPIFDAIqEATGARPYAGkvgaedDDRVDmAYRVVAD 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 295 HLKAAVFLIKDGVVPSNKEQGYFlRRLLRRLAVKIYQAKDEVSFEYVKKSISVIIKMYHDVyFKD--NNAEDISGIVAQE 372
Cdd:PLN02900 304 HIRTLSFAIADGVVPSNEGRGYV-LRRLLRRAVRYGRLLLGAEEGFFPALVEVVVELSGDV-FPEvkKNEKRITEIIAEE 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 373 FAKFGQTIKQGFKKIKDI---------DKISPKLAFDLYQSYGFPFEITKEIFEQRGQSLSQEEFNNYVKEHKKISRRSM 443
Cdd:PLN02900 382 ELSFGKTLEKGIEKFKKAlaaakanggPVLSGKDAFLLYDTYGFPVDLTELMAEERGVTVDMEGFEAAMEEARERSRAAH 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 444 FKKFKGGLADKEEQT--------------IKY------------------------------------------------ 461
Cdd:PLN02900 462 LKAGGGAIELAAEATswlqkqgvaatddfLKYdwlsdheavvkailtgggfvesvsegdevgivldktsfyaesggqigd 541
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 462 --------------------------------------------------------HTATHLIHQAITDLLGETVRQEGS 485
Cdd:PLN02900 542 tgvlegsggavvevsdvqkaggfvlhigtvtegsvsvgdavtckvdydrrrriapnHTATHLLNSALKEVLGDHVDQKGS 621
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 486 NITAERLRFDFYSNQKPDDNFKDKLEKIVNEKIKQGLPVRYEIMPKEKAYKI-GAKSFFKEKYPDKVKVYFIGE-YSKEF 563
Cdd:PLN02900 622 LVAFEKLRFDFSHGKPMTPEELREVESLVNEWIGDALPVEAKEMPLADAKRInGLRAVFGEKYPDPVRVVSVGGvYSMEL 701
|
730
....*....|...
gi 2315491310 564 CGGPHVANTSEIG 576
Cdd:PLN02900 702 CGGTHVSNTAEAE 714
|
|
| tRNA-synt_2c |
pfam01411 |
tRNA synthetases class II (A); Other tRNA synthetase sub-families are too dissimilar to be ... |
5-498 |
1.71e-96 |
|
tRNA synthetases class II (A); Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only alanyl-tRNA synthetases.
Pssm-ID: 279719 [Multi-domain] Cd Length: 548 Bit Score: 305.36 E-value: 1.71e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 5 ELRQRFSSFWESKDHKWVPPIPLIPVNDSTTLFTSSGMQQLVPYLLGQEH-PLGKRLYNIQPCFRSQDIEDIG-DNRHTT 82
Cdd:pfam01411 1 EIRQTFLDFFEKKGHTRVPSSPVVPRNDPTLLFTNAGMNQFKPIFLGGVAkPPYNRATNSQKCIRAGDLENVGrTGRHHT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 83 FFEMMGNWSLGDYFKTEQLNWVFEFLVQELGLNPNNLYVTVFsgwqklPEDKESILIWKKIfkqYGIQAevgERIFKYPA 162
Cdd:pfam01411 81 FFEMLGNFSFGDYFKEEAIEYAWELLTKELGLPPERLYVTVF------EWDDEAGPIWEKI---VGGPE---ERILRFGD 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 163 EKNWWSrsgvpenMPVNEPGGPDSEIFYkfdsvEHNKKFGDYCH---PNCDCGRFIEIGNSVFMQYKKTESGFVE-LPNK 238
Cdd:pfam01411 149 KDNFWE-------MGDTGPCGPCSEIDY-----DRGEEIGGWDSggtPTADDDRFLEIWNLVFMQFNRENDGTLKpLPKK 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 239 NVDFGGGLERILAACCNNPDVFLTDLYKPLINQLEVDLGFNYSNSDNKK-SLRIIADHLKAAVFLIKDGVVPSNKEQGYF 317
Cdd:pfam01411 217 SIDTGMGLERLVAVLQDVRSNYDTDVFIPVIELIEEISGARYYTVDETDeAYRVIADHTRALTFALADGVVPSNEGRGYV 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 318 lrrllrrlAVKI------YQAKDEVSFEYVKKSISVIIKMYHDVY--FKDNNaEDISGIVAQEFAKFGQTIKQGFKKI-- 387
Cdd:pfam01411 297 --------LRRIlrravrHAKKLGLKEPFLYDLVPTVVEVLGDAYpeLKEDE-DFIQEILELEEERFAKTLERGLRLLer 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 388 ------KDIDKISPKLAFDLYQSYGFPFEITKEIFEQRGQSLSQEEFNNYVKEHKKISRRSMfkkfKGGLADKEEQTIKY 461
Cdd:pfam01411 368 liaklkKGKKTLPGEDAFKLYDTYGFPVDLTKEIAEERGLKVDMPGFEYAMVEQRERSKQAV----KEKGEKLDVSALKE 443
|
490 500 510
....*....|....*....|....*....|....*..
gi 2315491310 462 HTAThlihqaiTDLLGETVRQEGSNITAerLRFDFYS 498
Cdd:pfam01411 444 LPAT-------TEFLGYDDLESEAKILA--LPKDGEF 471
|
|
| AlaRS_core |
cd00673 |
Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is ... |
5-252 |
3.34e-79 |
|
Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. Class II assignment is based upon its predicted structure and the presence of three characteristic sequence motifs.
Pssm-ID: 238360 [Multi-domain] Cd Length: 232 Bit Score: 249.58 E-value: 3.34e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 5 ELRQRFSSFWESKDHKWVPPIPLIPVNDSTTLFTSSGMQQLVPYLLGQEHPLGKRLYNIQPCFRSQDIEDIG-DNRHTTF 83
Cdd:cd00673 3 EIRETFLSFFEKKGHTRVPSSPVVPRDDPTLLFTNAGMNQFKPIFLGEVPPPANRLVNSQKCIRAGDIDNVGkTGRHHTF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 84 FEMMGNWSLGDYFKTEQLNWVFEFLVQELGLNPNNLYVTVFSGwqklPEDKESILIWKKIFkqygiqaeVGERIFKYPAE 163
Cdd:cd00673 83 FEMLGNFSFGDYFKEEAIAFAWELLTEVLGLPKDRLYVSVFEG----DDEEEAIWWWKIGL--------PGIRIERIGFK 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 164 KNWWSrsgvpenMPVNEPGGPDSEIFYkfdsvEHNKKFGDYCHPNCDCGRFIEIGNSVFMQYKKTESG-FVELPNKNVDF 242
Cdd:cd00673 151 DNFWE-------MGGNGPCGPCSEIFY-----DRGEERDAASLPNEDDDRYLEIWNLVFMQYNRDADGtYRPLPKKIVDT 218
|
250
....*....|
gi 2315491310 243 GGGLERILAA 252
Cdd:cd00673 219 GMGLERLVWV 228
|
|
| AlaX |
COG2872 |
Ser-tRNA(Ala) deacylase AlaX (editing enzyme) [Translation, ribosomal structure and biogenesis] ... |
460-576 |
1.54e-15 |
|
Ser-tRNA(Ala) deacylase AlaX (editing enzyme) [Translation, ribosomal structure and biogenesis];
Pssm-ID: 442119 [Multi-domain] Cd Length: 238 Bit Score: 76.38 E-value: 1.54e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 460 KYHTATHLIHQAITDLLGETVRqeGSNITAERLRFDFySNQKPDDNFKDKLEKIVNEKIKQGLPVRYEIMPKEKAYKI-G 538
Cdd:COG2872 98 RLHTALHLLSAVVYREYGAPVT--GGQIGEDRARIDF-DLPEFDEEDLEEIEAEANELIAADLPVRIYWITREELEAIpG 174
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 2315491310 539 AKSFFKEKYP---DKVKVYFIGEYSKEFCGGPHVANTSEIG 576
Cdd:COG2872 175 LVRTMSVLPPpgvGRVRIVEIGGVDLQPCGGTHVANTGEIG 215
|
|
| tRNA_SAD |
smart00863 |
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active form of ... |
551-576 |
2.30e-09 |
|
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active form of threonyl/alanyl tRNA synthetase is a dimer. Within the tRNA synthetase class II dimer, the bound tRNA interacts with both monomers making specific interactions with the catalytic domain, the C-terminal domain, and this SAD domain (the second additional domain). The second additional domain is comprised of a pair of perpendicularly orientated antiparallel beta sheets, of four and three strands, respectively, that surround a central alpha helix that forms the core of the domain.
Pssm-ID: 197931 [Multi-domain] Cd Length: 43 Bit Score: 53.15 E-value: 2.30e-09
|
| tRNA_SAD |
pfam07973 |
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active from of ... |
551-576 |
4.04e-09 |
|
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active from of threonyl/alanyl tRNA synthetase is a dimer. Within the tRNA synthetase class II dimer, the bound tRNA interacts with both monomers making specific interactions with the catalytic domain, the C-terminal domain, and this domain (the second additional domain). The second additional domain is comprised of a pair of perpendicularly orientated antiparallel beta sheets, of four and three strands, respectively, that surround a central alpha helix that forms the core of the domain.
Pssm-ID: 429764 [Multi-domain] Cd Length: 43 Bit Score: 52.45 E-value: 4.04e-09
|
| ThrS |
COG0441 |
Threonyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Threonyl-tRNA ... |
462-576 |
1.66e-08 |
|
Threonyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Threonyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440210 [Multi-domain] Cd Length: 639 Bit Score: 57.35 E-value: 1.66e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 462 HTATHLIHQAITDLLGET------VRQEGsnitaerlrF--DFYSNQK--PDDnFKdKLEKIVNEKIKQGLPVRYEIMPK 531
Cdd:COG0441 73 HSAAHLLAQAVKRLYPDAkltigpVIENG---------FyyDFDLERPftPED-LE-KIEKEMKEIIKEDLPIEREEVSR 141
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 2315491310 532 EKAYKigaksFFK---EKY----------PDKVKVYFIGEYsKEFCGGPHVANTSEIG 576
Cdd:COG0441 142 EEAIE-----LFKekgEPYkveliedipeDEEISLYRQGEF-VDLCRGPHVPSTGKIK 193
|
|
| PLN02961 |
PLN02961 |
alanine-tRNA ligase |
504-577 |
5.66e-07 |
|
alanine-tRNA ligase
Pssm-ID: 178546 [Multi-domain] Cd Length: 223 Bit Score: 50.85 E-value: 5.66e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2315491310 504 DNFKDKLEKIVNEKIKQGLPVRYEIMPKEKAYKI---GAKSFF-KEKYPDKVKvyfIGEYSKEFCGGPHVANTSEIGS 577
Cdd:PLN02961 130 DSKQDELEAEANELIAEGGKVSAAVLPYDEAAELcggSLPDYIaKDSTPRIVK---IGDSPGCPCGGTHVADVSEITS 204
|
|
| class_II_aaRS-like_core |
cd00768 |
Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA ... |
12-249 |
9.57e-05 |
|
Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches the amino acid at the 2'-OH group, like class I aaRSs. These enzymes are usually homodimers. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. The substrate specificity of this reaction is further determined by additional domains. Intererestingly, this domain is also found is asparagine synthase A (AsnA), in the accessory subunit of mitochondrial polymerase gamma and in the bacterial ATP phosphoribosyltransferase regulatory subunit HisZ.
Pssm-ID: 238391 [Multi-domain] Cd Length: 211 Bit Score: 44.03 E-value: 9.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 12 SFWESKDHKWVPPIPLIPVNDSTTLFTSSGMQQLVPYLLGQEHPLGKRLYNIQPCFRSqdiEDIG-DNRHTTFFEMMGNW 90
Cdd:cd00768 30 PLLEKAGHEPKDLLPVGAENEEDLYLRPTLEPGLVRLFVSHIRKLPLRLAEIGPAFRN---EGGRrGLRRVREFTQLEGE 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 91 SLGDYFktEQLNWVFEflVQELglnpnnlyvtVFSGWQKLpedkesILIWKKIFKQygiqaevgerifKYPAEKnwwsRS 170
Cdd:cd00768 107 VFGEDG--EEASEFEE--LIEL----------TEELLRAL------GIKLDIVFVE------------KTPGEF----SP 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 171 GvpenmpvnePGGPDSEIFYkfdsvehnkkfgdychpNCDCGRFIEIGNSVFMQYK---KTESGFVELPNK-----NVDF 242
Cdd:cd00768 151 G---------GAGPGFEIEV-----------------DHPEGRGLEIGSGGYRQDEqarAADLYFLDEALEyryppTIGF 204
|
....*..
gi 2315491310 243 GGGLERI 249
Cdd:cd00768 205 GLGLERL 211
|
|
| PLN02837 |
PLN02837 |
threonine-tRNA ligase |
462-575 |
7.57e-03 |
|
threonine-tRNA ligase
Pssm-ID: 215450 [Multi-domain] Cd Length: 614 Bit Score: 39.11 E-value: 7.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315491310 462 HTATHLIHQAITDLLGETVRQEGSNITaERLRFDFYSNQKPDDNFKdKLEKIVNEKIKQGLPVRYEIMPKEKA------- 534
Cdd:PLN02837 48 HTCAHVMAMAVQKLFPDAKVTIGPWIE-NGFYYDFDMEPLTDKDLK-RIKKEMDRIISRNLPLVREEVSREEAqkrimai 125
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 2315491310 535 ---YKIGAKSFFKEkypDKVKVYFIGEYSKEFCGGPHVANTSEI 575
Cdd:PLN02837 126 nepYKLEILEGIKE---EPITIYHIGEEWWDLCAGPHVERTGKI 166
|
|
| |
