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Conserved domains on  [gi|2067276446|dbj|GJB92002|]
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acyl-homoserine-lactone synthase [Aeromonas caviae]

Protein Classification

acyl-homoserine-lactone synthase( domain architecture ID 10008134)

acyl-homoserine-lactone (AHL) synthase is involved in regulating the expression of virulence genes in a process known as quorum-sensing; similar to Pseudomonas aeruginosa acyl-homoserinelactone synthase LasI and RhlI

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LasI COG3916
N-acyl-homoserine lactone synthase LasI (autoinducer biosynthesis) [Signal transduction ...
 18-195 1.05e-46

N-acyl-homoserine lactone synthase LasI (autoinducer biosynthesis) [Signal transduction mechanisms];


:

Pssm-ID: 443121 [Multi-domain]  Cd Length: 201  Bit Score: 152.78  E-value: 1.05e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2067276446  18 NELYRFRNRVFSDRLGWDVESRRGLERDNFDKPDTHWVLIEDKQG-LCGCIRLLSCAQDYMLPSIFPTALAGEAPPRGND 96
Cdd:COG3916    17 DEMFRLRHRVFVEELGWEVPVPDGLEIDQYDDPSAHYLLAHDEDGrVVGCVRLLPTTGPYMLEDVFPDLLDGGPAPRRPD 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2067276446  97 VWELTRLAIDADRAPRLENG--ISELTCVIFREVLAFAREQGIRELVAVVSLPVERIFRRLGLPIERLGhrQAVDLGAVR 174
Cdd:COG3916    97 IWEISRFAVDKDFRRRLGERarRPRVALALFLAMVEYALENGITHLVAVMEPRLERLLRRLGWPFEPLG--PPVEIGGER 174

                         170       180
                  ....*....|....*....|....*..
gi 2067276446 175 GVGIRFHLDE------RFDRAVHRPLQ 195
Cdd:COG3916   175 APAYLIDVDEetlarlRISGVLADALR 201
 
Name Accession Description Interval E-value
LasI COG3916
N-acyl-homoserine lactone synthase LasI (autoinducer biosynthesis) [Signal transduction ...
 18-195 1.05e-46

N-acyl-homoserine lactone synthase LasI (autoinducer biosynthesis) [Signal transduction mechanisms];


Pssm-ID: 443121 [Multi-domain]  Cd Length: 201  Bit Score: 152.78  E-value: 1.05e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2067276446  18 NELYRFRNRVFSDRLGWDVESRRGLERDNFDKPDTHWVLIEDKQG-LCGCIRLLSCAQDYMLPSIFPTALAGEAPPRGND 96
Cdd:COG3916    17 DEMFRLRHRVFVEELGWEVPVPDGLEIDQYDDPSAHYLLAHDEDGrVVGCVRLLPTTGPYMLEDVFPDLLDGGPAPRRPD 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2067276446  97 VWELTRLAIDADRAPRLENG--ISELTCVIFREVLAFAREQGIRELVAVVSLPVERIFRRLGLPIERLGhrQAVDLGAVR 174
Cdd:COG3916    97 IWEISRFAVDKDFRRRLGERarRPRVALALFLAMVEYALENGITHLVAVMEPRLERLLRRLGWPFEPLG--PPVEIGGER 174

                         170       180
                  ....*....|....*....|....*..
gi 2067276446 175 GVGIRFHLDE------RFDRAVHRPLQ 195
Cdd:COG3916   175 APAYLIDVDEetlarlRISGVLADALR 201
Autoind_synth pfam00765
Autoinducer synthase;
19-163 1.29e-30

Autoinducer synthase;


Pssm-ID: 366292  Cd Length: 182  Bit Score: 110.68  E-value: 1.29e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2067276446  19 ELYRFRNRVFSDRLGWDVESRRGLERDNFDKPDTHWVL-IEDKQGLCGCIRLLSCAQDYMLPSIFPTALAGEAPPRGNDV 97
Cdd:pfam00765  11 EMFRLRKRVFKDRLGWDVQIIQGMERDQYDNLDPTYLLgVKDEGRVIGCVRLLETKGPNMLTGTFSSYLDGENIPRSGNY 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2067276446  98 WELTRLAIDADRAP-RLENGISELTCVIFREVLAFAREQGIRELVAVVSLPVERIFRRLGLPIERLG 163
Cdd:pfam00765  91 WESSRFCVDTDLVSgRAGNSIAPATSTLFLGMIEYAMSAGYTGIVTIVDHPMLRILKRSGWPISYVG 157
PRK13834 PRK13834
putative autoinducer synthesis protein; Provisional
 18-168 2.91e-22

putative autoinducer synthesis protein; Provisional


Pssm-ID: 172361  Cd Length: 207  Bit Score: 89.74  E-value: 2.91e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2067276446  18 NELYRFRNRVFSDRLGWDVESRRGLERDNFD--KPdTHWVLIEDKQGLCGCIRLLSCAQDYMLPSIFPTALAG---EAPP 92
Cdd:PRK13834   19 KQMHRLRARVFGGRLGWDVSITDGEERDQFDdlKP-TYILAISDSGRVAGCARLLPAIGPTMLAQVFPQLLPAgrlNAHP 97

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2067276446  93 RgndVWELTRLAID-ADRAPRLENGISELTCVIFREVLAFAREQGIRELVAVVSLPVERIFRRLGLPIERLGHRQAV 168
Cdd:PRK13834   98 A---MIESSRFCVDtALAEGRGGGQLHEATLTMFAGIIEWSMANGYTEIVTATDLRFERILARAGWPMQRLGEPKAI 171
 
Name Accession Description Interval E-value
LasI COG3916
N-acyl-homoserine lactone synthase LasI (autoinducer biosynthesis) [Signal transduction ...
 18-195 1.05e-46

N-acyl-homoserine lactone synthase LasI (autoinducer biosynthesis) [Signal transduction mechanisms];


Pssm-ID: 443121 [Multi-domain]  Cd Length: 201  Bit Score: 152.78  E-value: 1.05e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2067276446  18 NELYRFRNRVFSDRLGWDVESRRGLERDNFDKPDTHWVLIEDKQG-LCGCIRLLSCAQDYMLPSIFPTALAGEAPPRGND 96
Cdd:COG3916    17 DEMFRLRHRVFVEELGWEVPVPDGLEIDQYDDPSAHYLLAHDEDGrVVGCVRLLPTTGPYMLEDVFPDLLDGGPAPRRPD 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2067276446  97 VWELTRLAIDADRAPRLENG--ISELTCVIFREVLAFAREQGIRELVAVVSLPVERIFRRLGLPIERLGhrQAVDLGAVR 174
Cdd:COG3916    97 IWEISRFAVDKDFRRRLGERarRPRVALALFLAMVEYALENGITHLVAVMEPRLERLLRRLGWPFEPLG--PPVEIGGER 174

                         170       180
                  ....*....|....*....|....*..
gi 2067276446 175 GVGIRFHLDE------RFDRAVHRPLQ 195
Cdd:COG3916   175 APAYLIDVDEetlarlRISGVLADALR 201
Autoind_synth pfam00765
Autoinducer synthase;
19-163 1.29e-30

Autoinducer synthase;


Pssm-ID: 366292  Cd Length: 182  Bit Score: 110.68  E-value: 1.29e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2067276446  19 ELYRFRNRVFSDRLGWDVESRRGLERDNFDKPDTHWVL-IEDKQGLCGCIRLLSCAQDYMLPSIFPTALAGEAPPRGNDV 97
Cdd:pfam00765  11 EMFRLRKRVFKDRLGWDVQIIQGMERDQYDNLDPTYLLgVKDEGRVIGCVRLLETKGPNMLTGTFSSYLDGENIPRSGNY 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2067276446  98 WELTRLAIDADRAP-RLENGISELTCVIFREVLAFAREQGIRELVAVVSLPVERIFRRLGLPIERLG 163
Cdd:pfam00765  91 WESSRFCVDTDLVSgRAGNSIAPATSTLFLGMIEYAMSAGYTGIVTIVDHPMLRILKRSGWPISYVG 157
PRK13834 PRK13834
putative autoinducer synthesis protein; Provisional
 18-168 2.91e-22

putative autoinducer synthesis protein; Provisional


Pssm-ID: 172361  Cd Length: 207  Bit Score: 89.74  E-value: 2.91e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2067276446  18 NELYRFRNRVFSDRLGWDVESRRGLERDNFD--KPdTHWVLIEDKQGLCGCIRLLSCAQDYMLPSIFPTALAG---EAPP 92
Cdd:PRK13834   19 KQMHRLRARVFGGRLGWDVSITDGEERDQFDdlKP-TYILAISDSGRVAGCARLLPAIGPTMLAQVFPQLLPAgrlNAHP 97

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2067276446  93 RgndVWELTRLAID-ADRAPRLENGISELTCVIFREVLAFAREQGIRELVAVVSLPVERIFRRLGLPIERLGHRQAV 168
Cdd:PRK13834   98 A---MIESSRFCVDtALAEGRGGGQLHEATLTMFAGIIEWSMANGYTEIVTATDLRFERILARAGWPMQRLGEPKAI 171
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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