NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2204124712|dbj|GKR74703|]
View 

D-amino acid dehydrogenase [Aeromonas caviae]

Protein Classification

D-amino acid dehydrogenase( domain architecture ID 11479161)

D-amino acid dehydrogenase catalyzes the oxidative deamination of D-amino acids to yield the corresponding 2-oxo acids; also able to oxidize D-amino acid analogs

EC:  1.4.99.-
Gene Ontology:  GO:0071949|GO:0016491|GO:0008718|GO:0055130
SCOP:  3000055

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK00711 PRK00711
D-amino acid dehydrogenase;
14-416 0e+00

D-amino acid dehydrogenase;


:

Pssm-ID: 234819 [Multi-domain]  Cd Length: 416  Bit Score: 753.94  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712  14 TSAWYLAKAGHKVTLLERRDGVALETSHANAGQISPGYASPWAAPGIPLKAAKWLLQKHAPFTVRPTSDPFQLRWMLKMF 93
Cdd:PRK00711   14 TSAWYLAQAGHEVTVIDRQPGPALETSFANAGQISPGYAAPWAAPGVPLKAIKWLFQRHAPLAIRPDGDPFQLRWMWQML 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712  94 ANCTPAAYAVNKGRMVRLAEYSRDCMKQLRGELALDYEGRQLGTLQLFRSQAQLDASQRDIAVLEEYGVPYQSLNADGCE 173
Cdd:PRK00711   94 RNCTASRYAVNKSRMVRLAEYSRDCLKALRAETGIQYEGRQGGTLQLFRTQQQLDAAAKDIAVLEEAGVPYELLDRDELA 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 174 EVEPALARVRGKVVGGLRLPGDETGDCFRFTQALADEARKLGVSFVFNCAIDEVEIAKGRAVAVRAGEQRFQADAIVCAL 253
Cdd:PRK00711  174 AVEPALAGVRHKLVGGLRLPNDETGDCQLFTQRLAAMAEQLGVKFRFNTPVDGLLVEGGRITGVQTGGGVITADAYVVAL 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 254 GSYGTGFLRPLGIELPVYPVKGYSLTLPMTDAEGAPRSTVLDETYKVAITRFDERIRVGGMAELSGFNLALNPRRHDTLA 333
Cdd:PRK00711  254 GSYSTALLKPLGVDIPVYPLKGYSLTVPITDEDRAPVSTVLDETYKIAITRFDDRIRVGGMAEIVGFDLRLDPARRETLE 333

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 334 MVVRDLFPQGGNLEQATFWAGLRPMTPDGTPLVGPSPIPGLWLNTGHGTLGWTMAAGSGQLLSDLISGNTPDISDEGLTL 413
Cdd:PRK00711  334 MVVRDLFPGGGDLSQATFWTGLRPMTPDGTPIVGATRYKNLWLNTGHGTLGWTMACGSGQLLADLISGRKPAIDADDLSV 413


                  ...
gi 2204124712 414 ARY 416
Cdd:PRK00711  414 ARY 416
 
Name Accession Description Interval E-value
PRK00711 PRK00711
D-amino acid dehydrogenase;
14-416 0e+00

D-amino acid dehydrogenase;


Pssm-ID: 234819 [Multi-domain]  Cd Length: 416  Bit Score: 753.94  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712  14 TSAWYLAKAGHKVTLLERRDGVALETSHANAGQISPGYASPWAAPGIPLKAAKWLLQKHAPFTVRPTSDPFQLRWMLKMF 93
Cdd:PRK00711   14 TSAWYLAQAGHEVTVIDRQPGPALETSFANAGQISPGYAAPWAAPGVPLKAIKWLFQRHAPLAIRPDGDPFQLRWMWQML 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712  94 ANCTPAAYAVNKGRMVRLAEYSRDCMKQLRGELALDYEGRQLGTLQLFRSQAQLDASQRDIAVLEEYGVPYQSLNADGCE 173
Cdd:PRK00711   94 RNCTASRYAVNKSRMVRLAEYSRDCLKALRAETGIQYEGRQGGTLQLFRTQQQLDAAAKDIAVLEEAGVPYELLDRDELA 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 174 EVEPALARVRGKVVGGLRLPGDETGDCFRFTQALADEARKLGVSFVFNCAIDEVEIAKGRAVAVRAGEQRFQADAIVCAL 253
Cdd:PRK00711  174 AVEPALAGVRHKLVGGLRLPNDETGDCQLFTQRLAAMAEQLGVKFRFNTPVDGLLVEGGRITGVQTGGGVITADAYVVAL 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 254 GSYGTGFLRPLGIELPVYPVKGYSLTLPMTDAEGAPRSTVLDETYKVAITRFDERIRVGGMAELSGFNLALNPRRHDTLA 333
Cdd:PRK00711  254 GSYSTALLKPLGVDIPVYPLKGYSLTVPITDEDRAPVSTVLDETYKIAITRFDDRIRVGGMAEIVGFDLRLDPARRETLE 333

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 334 MVVRDLFPQGGNLEQATFWAGLRPMTPDGTPLVGPSPIPGLWLNTGHGTLGWTMAAGSGQLLSDLISGNTPDISDEGLTL 413
Cdd:PRK00711  334 MVVRDLFPGGGDLSQATFWTGLRPMTPDGTPIVGATRYKNLWLNTGHGTLGWTMACGSGQLLADLISGRKPAIDADDLSV 413


                  ...
gi 2204124712 414 ARY 416
Cdd:PRK00711  414 ARY 416
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
14-415 1.28e-105

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 316.46  E-value: 1.28e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712  14 TSAWYLAKAGHKVTLLERrDGVALETSHANAGQISPGYASPWAApgiplkaakwllqkhapftvrptsdpfqlrwmlkmf 93
Cdd:COG0665    16 STAYHLARRGLDVTVLER-GRPGSGASGRNAGQLRPGLAALADR------------------------------------ 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712  94 anctpaayavnkgRMVRLAEYSRDCMKQLRGELALDYEGRQLGTLQLFRSQAQLDASQRDIAVLEEYGVPYQSLNADGCE 173
Cdd:COG0665    59 -------------ALVRLAREALDLWRELAAELGIDCDFRRTGVLYLARTEAELAALRAEAEALRALGLPVELLDAAELR 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 174 EVEPALARvrGKVVGGLRLPGDETGDCFRFTQALADEARKLGVSFVFNCAIDEVEIAKGRAVAVRAGEQRFQADAIVCAL 253
Cdd:COG0665   126 EREPGLGS--PDYAGGLYDPDDGHVDPAKLVRALARAARAAGVRIREGTPVTGLEREGGRVTGVRTERGTVRADAVVLAA 203

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 254 GSYGTGFLRPLGIELPVYPVKGYSLTLPMTDAegAPRSTVLDETYKVAITRFDERIRVGGMAELSGFNLALNPRRHDTLA 333
Cdd:COG0665   204 GAWSARLLPMLGLRLPLRPVRGYVLVTEPLPD--LPLRPVLDDTGVYLRPTADGRLLVGGTAEPAGFDRAPTPERLEALL 281

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 334 MVVRDLFPQGGNLEQATFWAGLRPMTPDGTPLVGPSP-IPGLWLNTGHGTLGWTMAAGSGQLLSDLISGNTPDISDEGLT 412
Cdd:COG0665   282 RRLRRLFPALADAEIVRAWAGLRPMTPDGLPIIGRLPgAPGLYVATGHGGHGVTLAPAAGRLLADLILGGEPPLDLAPFS 361


                  ...
gi 2204124712 413 LAR 415
Cdd:COG0665   362 PDR 364
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 14-398 6.72e-72

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 229.21  E-value: 6.72e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712  14 TSAWYLAKAGHKVTLLERRDGVALETSHANAGQISPGYASPwaapgiplkaakwllqkhapftvrptsdpfqlrwmlkmf 93
Cdd:pfam01266  13 STAYELARRGLSVTLLERGDDPGSGASGRNAGLIHPGLRYL--------------------------------------- 53

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712  94 anctpaayavNKGRMVRLAEYSRDCMKQLRGELALDYEGRQLGTLQLFRSQAQlDASQRDIAVLEEYGVPYQSLNADGCE 173
Cdd:pfam01266  54 ----------EPSELARLALEALDLWEELEEELGIDCGFRRCGVLVLARDEEE-EALEKLLAALRRLGVPAELLDAEELR 122

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 174 EVEPALARVRGkvvgGLRLPGDETGDCFRFTQALADEARKLGVSFVFNCAIDEVEIAKGRAVAVRAGEqrfqADAIVCAL 253
Cdd:pfam01266 123 ELEPLLPGLRG----GLFYPDGGHVDPARLLRALARAAEALGVRIIEGTEVTGIEEEGGVWGVVTTGE----ADAVVNAA 194

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 254 GSYgTGFLRPLGIELPVYPVKGYSLTL-PMTDAEGAP--RSTVLDETYKVAITRFDERIRVGGMAELSGFN-LALNPRRH 329
Cdd:pfam01266 195 GAW-ADLLALPGLRLPVRPVRGQVLVLePLPEALLILpvPITVDPGRGVYLRPRADGRLLLGGTDEEDGFDdPTPDPEEI 273

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2204124712 330 DTLAMVVRDLFPQGGNLEQAtfWAGLRPMtPDGTPLVGPSPIPGLWLNTGHGTLGWTMAAGSGQLLSDL 398
Cdd:pfam01266 274 EELLEAARRLFPALADIERA--WAGLRPL-PDGLPIIGRPGSPGLYLATGHGGHGLTLAPGIGKLLAEL 339
thiamin_ThiO TIGR02352
glycine oxidase ThiO; This family consists of the homotetrameric, FAD-dependent glycine ...
 17-401 4.95e-42

glycine oxidase ThiO; This family consists of the homotetrameric, FAD-dependent glycine oxidase ThiO, from species such as Bacillus subtilis that use glycine in thiamine biosynthesis. In general, members of this family will not be found in species such as E. coli that instead use tyrosine and the ThiH protein. [Biosynthesis of cofactors, prosthetic groups, and carriers, Thiamine]


Pssm-ID: 274092 [Multi-domain]  Cd Length: 337  Bit Score: 150.98  E-value: 4.95e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712  17 WYLAKAGHKVTLLERrDGVALETSHANAGqispgyaspwaapgiplkaakwllqkhapftvrptsdpfqlrwMLKMFANC 96
Cdd:TIGR02352   1 WELAKRGHSVTLFDR-DPMGGGASWAAAG-------------------------------------------MLAPHAEC 36

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712  97 TPAayavnKGRMVRLAEYSRDCMKQLRGELA----LDYEGRQLGTLQLFRSQAQLDASQRDIAVLEEYGVPYQSLNADGC 172
Cdd:TIGR02352  37 EYA-----EDPLFDLALESLRLYPEWLEALKeltgLDTGYHQCGTLVVAFDEDDVEHLRQLADLQSATGMEVEWLSGRAL 111

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 173 EEVEPALArvrGKVVGGLRLPGDETGDCFRFTQALADEARKLGVSFVFNCAIDEVEIAKGRAVAVRAGEQRFQADAIVCA 252
Cdd:TIGR02352 112 RRLEPYLS---GGIRGAVFYPDDAHVDPRALLKALEKALEKLGVEIIEHTEVQHIEIRGEKVTAIVTPSGDVQADQVVLA 188

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 253 LGSYGTGFLrplgiELPVYPVKGYSLTLPMTDAEGAP---RSTVLDETYKVaITRFDERIRVGGMAELSGFNLALNPRRH 329
Cdd:TIGR02352 189 AGAWAGELL-----PLPLRPVRGQPLRLEAPAVPLLNrplRAVVYGRRVYI-VPRRDGRLVVGATMEESGFDTTPTLGGI 262

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2204124712 330 DTLAMVVRDLFPQGGNLEQATFWAGLRPMTPDGTPLVGPSP-IPGLWLNTGHGTLGWTMAAGSGQLLSDLISG 401
Cdd:TIGR02352 263 KELLRDAYTILPALKEARLLETWAGLRPGTPDNLPYIGEHPeDRRLLIATGHYRNGILLAPATAEVIADLILG 335
 
Name Accession Description Interval E-value
PRK00711 PRK00711
D-amino acid dehydrogenase;
14-416 0e+00

D-amino acid dehydrogenase;


Pssm-ID: 234819 [Multi-domain]  Cd Length: 416  Bit Score: 753.94  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712  14 TSAWYLAKAGHKVTLLERRDGVALETSHANAGQISPGYASPWAAPGIPLKAAKWLLQKHAPFTVRPTSDPFQLRWMLKMF 93
Cdd:PRK00711   14 TSAWYLAQAGHEVTVIDRQPGPALETSFANAGQISPGYAAPWAAPGVPLKAIKWLFQRHAPLAIRPDGDPFQLRWMWQML 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712  94 ANCTPAAYAVNKGRMVRLAEYSRDCMKQLRGELALDYEGRQLGTLQLFRSQAQLDASQRDIAVLEEYGVPYQSLNADGCE 173
Cdd:PRK00711   94 RNCTASRYAVNKSRMVRLAEYSRDCLKALRAETGIQYEGRQGGTLQLFRTQQQLDAAAKDIAVLEEAGVPYELLDRDELA 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 174 EVEPALARVRGKVVGGLRLPGDETGDCFRFTQALADEARKLGVSFVFNCAIDEVEIAKGRAVAVRAGEQRFQADAIVCAL 253
Cdd:PRK00711  174 AVEPALAGVRHKLVGGLRLPNDETGDCQLFTQRLAAMAEQLGVKFRFNTPVDGLLVEGGRITGVQTGGGVITADAYVVAL 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 254 GSYGTGFLRPLGIELPVYPVKGYSLTLPMTDAEGAPRSTVLDETYKVAITRFDERIRVGGMAELSGFNLALNPRRHDTLA 333
Cdd:PRK00711  254 GSYSTALLKPLGVDIPVYPLKGYSLTVPITDEDRAPVSTVLDETYKIAITRFDDRIRVGGMAEIVGFDLRLDPARRETLE 333

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 334 MVVRDLFPQGGNLEQATFWAGLRPMTPDGTPLVGPSPIPGLWLNTGHGTLGWTMAAGSGQLLSDLISGNTPDISDEGLTL 413
Cdd:PRK00711  334 MVVRDLFPGGGDLSQATFWTGLRPMTPDGTPIVGATRYKNLWLNTGHGTLGWTMACGSGQLLADLISGRKPAIDADDLSV 413


                  ...
gi 2204124712 414 ARY 416
Cdd:PRK00711  414 ARY 416
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
14-415 1.28e-105

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 316.46  E-value: 1.28e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712  14 TSAWYLAKAGHKVTLLERrDGVALETSHANAGQISPGYASPWAApgiplkaakwllqkhapftvrptsdpfqlrwmlkmf 93
Cdd:COG0665    16 STAYHLARRGLDVTVLER-GRPGSGASGRNAGQLRPGLAALADR------------------------------------ 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712  94 anctpaayavnkgRMVRLAEYSRDCMKQLRGELALDYEGRQLGTLQLFRSQAQLDASQRDIAVLEEYGVPYQSLNADGCE 173
Cdd:COG0665    59 -------------ALVRLAREALDLWRELAAELGIDCDFRRTGVLYLARTEAELAALRAEAEALRALGLPVELLDAAELR 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 174 EVEPALARvrGKVVGGLRLPGDETGDCFRFTQALADEARKLGVSFVFNCAIDEVEIAKGRAVAVRAGEQRFQADAIVCAL 253
Cdd:COG0665   126 EREPGLGS--PDYAGGLYDPDDGHVDPAKLVRALARAARAAGVRIREGTPVTGLEREGGRVTGVRTERGTVRADAVVLAA 203

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 254 GSYGTGFLRPLGIELPVYPVKGYSLTLPMTDAegAPRSTVLDETYKVAITRFDERIRVGGMAELSGFNLALNPRRHDTLA 333
Cdd:COG0665   204 GAWSARLLPMLGLRLPLRPVRGYVLVTEPLPD--LPLRPVLDDTGVYLRPTADGRLLVGGTAEPAGFDRAPTPERLEALL 281

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 334 MVVRDLFPQGGNLEQATFWAGLRPMTPDGTPLVGPSP-IPGLWLNTGHGTLGWTMAAGSGQLLSDLISGNTPDISDEGLT 412
Cdd:COG0665   282 RRLRRLFPALADAEIVRAWAGLRPMTPDGLPIIGRLPgAPGLYVATGHGGHGVTLAPAAGRLLADLILGGEPPLDLAPFS 361


                  ...
gi 2204124712 413 LAR 415
Cdd:COG0665   362 PDR 364
PRK12409 PRK12409
D-amino acid dehydrogenase small subunit; Provisional
 14-399 3.98e-80

D-amino acid dehydrogenase small subunit; Provisional


Pssm-ID: 237093 [Multi-domain]  Cd Length: 410  Bit Score: 252.64  E-value: 3.98e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712  14 TSAWYLAKAGHKVTLLERRDGVALETSHANAGQISPGYASPWAAPGIPLKAAKWLLQKHAPFTVRPTSDPFQLRWMLKMF 93
Cdd:PRK12409   15 TTAYALAQRGYQVTVFDRHRYAAMETSFANGGQLSASNAEVWNHWATVLKGLKWMLRKDAPLLLNPKPSWHKYSWLAEFL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712  94 ANCtpAAYAVNKGRMVRLAEYSRDCMKQLRGELALDYEGRQLGTLQLFRSQAQLDASQRDIAVLEEYGVPYQSLNADGCE 173
Cdd:PRK12409   95 AHI--PNYRANTIETVRLAIAARKHLFDIAEREGIDFDLERRGILHIYHDKAGFDHAKRVNALLAEGGLERRAVTPEEMR 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 174 EVEPALArvrGKVVGGLRLPGDETGDCFRFTQALADEARKLGVSFVFNCAIDEVEI-AKGRAVAVRAGE----QRFQADA 248
Cdd:PRK12409  173 AIEPTLT---GEYYGGYYTPSDSTGDIHKFTTGLAAACARLGVQFRYGQEVTSIKTdGGGVVLTVQPSAehpsRTLEFDG 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 249 IV-CA-LGSYgtGFLRPLGIELPVYPVKGYSLTLPMTDAE---GAPRSTVLDETYKVAITRF-DERIRVGGMAELSGFNL 322
Cdd:PRK12409  250 VVvCAgVGSR--ALAAMLGDRVNVYPVKGYSITVNLDDEAsraAAPWVSLLDDSAKIVTSRLgADRFRVAGTAEFNGYNR 327

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2204124712 323 ALNPRRHDTLAMVVRDLFPqGGNLEQATFWAGLRPMTPDGTPLVGPSPIPGLWLNTGHGTLGWTMAAGSGQLLSDLI 399
Cdd:PRK12409  328 DIRADRIRPLVDWVRRNFP-DVSTRRVVPWAGLRPMMPNMMPRVGRGRRPGVFYNTGHGHLGWTLSAATADLVAQVV 403
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 14-398 6.72e-72

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 229.21  E-value: 6.72e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712  14 TSAWYLAKAGHKVTLLERRDGVALETSHANAGQISPGYASPwaapgiplkaakwllqkhapftvrptsdpfqlrwmlkmf 93
Cdd:pfam01266  13 STAYELARRGLSVTLLERGDDPGSGASGRNAGLIHPGLRYL--------------------------------------- 53

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712  94 anctpaayavNKGRMVRLAEYSRDCMKQLRGELALDYEGRQLGTLQLFRSQAQlDASQRDIAVLEEYGVPYQSLNADGCE 173
Cdd:pfam01266  54 ----------EPSELARLALEALDLWEELEEELGIDCGFRRCGVLVLARDEEE-EALEKLLAALRRLGVPAELLDAEELR 122

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 174 EVEPALARVRGkvvgGLRLPGDETGDCFRFTQALADEARKLGVSFVFNCAIDEVEIAKGRAVAVRAGEqrfqADAIVCAL 253
Cdd:pfam01266 123 ELEPLLPGLRG----GLFYPDGGHVDPARLLRALARAAEALGVRIIEGTEVTGIEEEGGVWGVVTTGE----ADAVVNAA 194

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 254 GSYgTGFLRPLGIELPVYPVKGYSLTL-PMTDAEGAP--RSTVLDETYKVAITRFDERIRVGGMAELSGFN-LALNPRRH 329
Cdd:pfam01266 195 GAW-ADLLALPGLRLPVRPVRGQVLVLePLPEALLILpvPITVDPGRGVYLRPRADGRLLLGGTDEEDGFDdPTPDPEEI 273

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2204124712 330 DTLAMVVRDLFPQGGNLEQAtfWAGLRPMtPDGTPLVGPSPIPGLWLNTGHGTLGWTMAAGSGQLLSDL 398
Cdd:pfam01266 274 EELLEAARRLFPALADIERA--WAGLRPL-PDGLPIIGRPGSPGLYLATGHGGHGLTLAPGIGKLLAEL 339
thiamin_ThiO TIGR02352
glycine oxidase ThiO; This family consists of the homotetrameric, FAD-dependent glycine ...
 17-401 4.95e-42

glycine oxidase ThiO; This family consists of the homotetrameric, FAD-dependent glycine oxidase ThiO, from species such as Bacillus subtilis that use glycine in thiamine biosynthesis. In general, members of this family will not be found in species such as E. coli that instead use tyrosine and the ThiH protein. [Biosynthesis of cofactors, prosthetic groups, and carriers, Thiamine]


Pssm-ID: 274092 [Multi-domain]  Cd Length: 337  Bit Score: 150.98  E-value: 4.95e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712  17 WYLAKAGHKVTLLERrDGVALETSHANAGqispgyaspwaapgiplkaakwllqkhapftvrptsdpfqlrwMLKMFANC 96
Cdd:TIGR02352   1 WELAKRGHSVTLFDR-DPMGGGASWAAAG-------------------------------------------MLAPHAEC 36

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712  97 TPAayavnKGRMVRLAEYSRDCMKQLRGELA----LDYEGRQLGTLQLFRSQAQLDASQRDIAVLEEYGVPYQSLNADGC 172
Cdd:TIGR02352  37 EYA-----EDPLFDLALESLRLYPEWLEALKeltgLDTGYHQCGTLVVAFDEDDVEHLRQLADLQSATGMEVEWLSGRAL 111

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 173 EEVEPALArvrGKVVGGLRLPGDETGDCFRFTQALADEARKLGVSFVFNCAIDEVEIAKGRAVAVRAGEQRFQADAIVCA 252
Cdd:TIGR02352 112 RRLEPYLS---GGIRGAVFYPDDAHVDPRALLKALEKALEKLGVEIIEHTEVQHIEIRGEKVTAIVTPSGDVQADQVVLA 188

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 253 LGSYGTGFLrplgiELPVYPVKGYSLTLPMTDAEGAP---RSTVLDETYKVaITRFDERIRVGGMAELSGFNLALNPRRH 329
Cdd:TIGR02352 189 AGAWAGELL-----PLPLRPVRGQPLRLEAPAVPLLNrplRAVVYGRRVYI-VPRRDGRLVVGATMEESGFDTTPTLGGI 262

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2204124712 330 DTLAMVVRDLFPQGGNLEQATFWAGLRPMTPDGTPLVGPSP-IPGLWLNTGHGTLGWTMAAGSGQLLSDLISG 401
Cdd:TIGR02352 263 KELLRDAYTILPALKEARLLETWAGLRPGTPDNLPYIGEHPeDRRLLIATGHYRNGILLAPATAEVIADLILG 335
LhgO COG0579
L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];
16-374 1.43e-16

L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];


Pssm-ID: 440344 [Multi-domain]  Cd Length: 418  Bit Score: 80.96  E-value: 1.43e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712  16 AWYLAKA-GHKVTLLERRDGVALETSHANAGQISPGYAspwAAPGiPLKAAKwllqkhapftvrptsdpfqlrwmlkmfa 94
Cdd:COG0579    20 ARELSRYeDLKVLVLEKEDDVAQESSGNNSGVIHAGLY---YTPG-SLKARL---------------------------- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712  95 nctpaAYAVNKgrmvRLAEYSRdcmkqlrgELALDYegRQLGTLQLFRSQAQLDASQRDIAVLEEYGVPY-QSLNADGCE 173
Cdd:COG0579    68 -----CVEGNE----LFYELCR--------ELGIPF--KRCGKLVVATGEEEVAFLEKLYERGKANGVPGlEILDREELR 128

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 174 EVEPAlarVRGKVVGGLRLPgdETGDC--FRFTQALADEARKLGVSFVFNCAIDEVEIAKGRaVAVRAGEQRFQADAIVC 251
Cdd:COG0579   129 ELEPL---LSDEGVAALYSP--STGIVdpGALTRALAENAEANGVELLLNTEVTGIEREGDG-WEVTTNGGTIRARFVIN 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 252 ALGSYGTGFLRPLGIELPV--YPVKG--YSLT----------LPMTDAEGAPRStvldetykVAITRF-DERIRVG---G 313
Cdd:COG0579   203 AAGLYADRLAQMAGIGKDFgiFPVKGeyLVLDkpaelvnakvYPVPDPGAPFLG--------VHLTRTiDGNLLFGpnaV 274

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 314 MAE--------------------------LSGFNLALNPRRHDTLAMVVRDLFP--QGGNLEQATfwAGLRP--MTPDGT 363
Cdd:COG0579   275 FVPkkedslldlfeslrfpnfwpmlaknlLTKYLESVTSLSKEAFLEALRKYVPelPDEDLIPAF--AGIRAqiIKPDGD 352

                         410
                  ....*....|.
gi 2204124712 364 PLVGPSPIPGL 374
Cdd:COG0579   353 FVIEEADDPGS 363
MnmC_Cterm TIGR03197
tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; In ...
 16-401 1.16e-08

tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; In Escherichia coli, the protein previously designated YfcK is now identified as the bifunctional enzyme MnmC. It acts, following the action of the heterotetramer of GidA and MnmE, in the modification of U-34 of certain tRNA to 5-methylaminomethyl-2-thiouridine (mnm5s2U). In other bacterial, the corresponding proteins are usually but always found as a single polypeptide chain, but occasionally as the product of tandem genes. This model represents the C-terminal region of the multifunctional protein. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 274478 [Multi-domain]  Cd Length: 381  Bit Score: 56.51  E-value: 1.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712  16 AWYLAKAGHKVTLLERRDGVALETSHANAGQISPgyaspwaapgiplkaakwLLQKHapftvrptsDPFQLRWMLKMFAn 95
Cdd:TIGR03197   2 AYSLARRGWQVTLYEQDEAPAQGASGNPQGALYP------------------LLSAD---------DNPLSRFFLAAFL- 53

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712  96 ctpaayavnkgrmvrlaeYSRDCMKQL-RGELALDYEGRqlGTLQLFRSQAqldASQRDIAVLEEYGVP---YQSLNADG 171
Cdd:TIGR03197  54 ------------------YARRFYRQLaEAGFPFDHEWC--GVLQLAYDEK---EAERLQKLLEQLGFPeelARWVDAEQ 110

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 172 CEEvepaLARVrGKVVGGLRLPgdETG--DCFRFTQALADEARkLGVSFVFNCAIDEVEIAKGRAVAVRAGEQRFQADAI 249
Cdd:TIGR03197 111 ASQ----LAGI-PLPYGGLFFP--QGGwlSPPQLCRALLAHAG-IRLTLHFNTEITSLERDGEGWQLLDANGEVIAASVV 182

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 250 VCAlGSYGTGFLRPLGiELPVYPVKGYSLTLPMTDAEGAPRSTVLDETYkVAITRFDERIrVGGMAELSGFNLALNPRRH 329
Cdd:TIGR03197 183 VLA-NGAQAPQLAQTA-HLPLRPVRGQVSHLPATEALSALKTVLCYDGY-LTPANNGEHC-IGASYDRNDDDLALREADH 258

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 330 DTLAMVVRDLFPQ-----GGNLEQATFWAGLRPMTPDGTPLVGPSP--------------------------IPGLWLNT 378
Cdd:TIGR03197 259 AENLERLAECLPAlawasEVDISALQGRVGVRCASPDHLPLVGAVPdfeaikeayaelakdknrpiaepapyYPGLYVLG 338

                         410       420
                  ....*....|....*....|...
gi 2204124712 379 GHGTLGWTMAAGSGQLLSDLISG 401
Cdd:TIGR03197 339 GLGSRGLTSAPLAAEILAAQICG 361
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 202-252 9.46e-07

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 50.62  E-value: 9.46e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2204124712 202 RFTQALADEARKLGVSFVFNCAIDEVEIAKGRAVAVR-AGEQRFQADAIVCA 252
Cdd:COG1233   223 ALADALARLAEELGGEIRTGAEVERILVEGGRATGVRlADGEEIRADAVVSN 274
SdhA COG1053
Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and ...
 147-257 4.05e-05

Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440673 [Multi-domain]  Cd Length: 443  Bit Score: 45.59  E-value: 4.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 147 LDASQRDIAVLEEYGVPYQSlnadgceEVEPALARVRGKVVGGLRLPGDETGdcFRFTQALADEARKLGVSFVFNCAIDE 226
Cdd:COG1053    89 AEEAPEAIDWLEAQGVPFSR-------TPDGRLPQFGGHSVGRTCYAGDGTG--HALLATLYQAALRLGVEIFTETEVLD 159

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2204124712 227 VEIAKGRAVAVRA-----GEQRFQADAIVCALGSYG 257
Cdd:COG1053   160 LIVDDGRVVGVVArdrtgEIVRIRAKAVVLATGGFG 195
FixC COG0644
Dehydrogenase (flavoprotein) [Energy production and conversion];
202-280 1.55e-04

Dehydrogenase (flavoprotein) [Energy production and conversion];


Pssm-ID: 440409 [Multi-domain]  Cd Length: 281  Bit Score: 43.42  E-value: 1.55e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2204124712 202 RFTQALADEARKLGVSFVFNCAIDEVEIAKGRAVAVRAGEQRFQADAIVCALGSYGTgFLRPLGIELPVYPVKGYSLTL 280
Cdd:COG0644    87 RFDRWLAEQAEEAGAEVRTGTRVTDVLRDDGRVVVRTGDGEEIRADYVVDADGARSL-LARKLGLKRRSDEPQDYALAI 164
mnmC PRK01747
bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent ...
 19-401 5.19e-04

bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC;


Pssm-ID: 234978 [Multi-domain]  Cd Length: 662  Bit Score: 42.14  E-value: 5.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712  19 LAKAGHKVTLLERRDGVALETSHANAGQISPgyaspwaapgiplkaakwLLQKHapftvrptsdpfqlrwmlkmfanctp 98
Cdd:PRK01747  279 LARRGWQVTLYEADEAPAQGASGNRQGALYP------------------LLSKD-------------------------- 314

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712  99 aayAVNKGRMVRLA-EYSRDCMKQL-RGELALDYEGRqlGTLQLFRSqaqlDASQRDIAVLEEYGVP---YQSLNADgce 173
Cdd:PRK01747  315 ---DNALSRFFRAAfLFARRFYDALpAAGVAFDHDWC--GVLQLAWD----EKSAEKIAKMLALGLPaelARALDAE--- 382

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 174 evepALARVRGKVV--GGLRLPGdetGDCFR---FTQALADEArKLGVSFVFNCAIDEVEIAKGRAVAVRAGEQRFQADA 248
Cdd:PRK01747  383 ----EAEELAGLPVpcGGIFYPQ---GGWLCpaeLCRALLALA-GQQLTIHFGHEVARLEREDDGWQLDFAGGTLASAPV 454

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 249 IVCALGSYGTGFlrPLGIELPVYPVKGYSLTLPMTDAEGAPRSTVLDETYKVAITRFDERiRVGGMAELSGFNLALNPRR 328
Cdd:PRK01747  455 VVLANGHDAARF--AQTAHLPLYSVRGQVSHLPTTPALSALKQVLCYDGYLTPQPANGTH-CIGASYDRDDTDTAFREAD 531

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 329 H-DTLAMVVRDL----FPQGGNLEQATFWAGLRPMTPDGTPLVGPSP-----------------------IPGLWLNTGH 380
Cdd:PRK01747  532 HqENLERLAECLpqalWAKEVDVSALQGRVGFRCASRDRLPMVGNVPdeaatlaeyaalanqqpardaprLPGLYVAGAL 611

                         410       420
                  ....*....|....*....|.
gi 2204124712 381 GTLGWTMAAGSGQLLSDLISG 401
Cdd:PRK01747  612 GSRGLCSAPLGAELLASQIEG 632
PRK11728 PRK11728
L-2-hydroxyglutarate oxidase;
161-252 2.81e-03

L-2-hydroxyglutarate oxidase;


Pssm-ID: 183292 [Multi-domain]  Cd Length: 393  Bit Score: 39.80  E-value: 2.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2204124712 161 GVPYQSLNADGCEEVEPalaRVRGkvVGGLRLPgdETG--DCFRFTQALADEARKLGVSFVFNC---AIDEveiaKGRAV 235
Cdd:PRK11728  114 GIEVERLDAEELREREP---NIRG--LGAIFVP--STGivDYRAVAEAMAELIQARGGEIRLGAevtALDE----HANGV 182

                          90
                  ....*....|....*...
gi 2204124712 236 AVRAGEQRFQAD-AIVCA 252
Cdd:PRK11728  183 VVRTTQGEYEARtLINCA 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH