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Conserved domains on  [gi|1736062557|gb|KAA0544288|]
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protein-export chaperone SecB [Citrobacter portucalensis]

Protein Classification

protein-export chaperone SecB( domain architecture ID 10012585)

protein-export chaperone SecB, a component of the multisubunit membrane-bound enzyme Sec protein translocase, functions as an export-specific molecular chaperone that selectively binds preproteins, maintains them in a translocation competent state and delivers them to SecA, the membrane-bound ATPase that drives the translocation reaction

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK05751 PRK05751
preprotein translocase subunit SecB; Validated
1-151 6.20e-94

preprotein translocase subunit SecB; Validated


:

Pssm-ID: 180234  Cd Length: 156  Bit Score: 268.63  E-value: 6.20e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736062557   1 MSEQNNT--EMAFQIQRIYTKDVSFEAPNAPHVFQKDWQPEVKLDLDTASTQLADDVYEVVLRVTVTASLGEETAFLCEV 78
Cdd:PRK05751    1 MSEQNNTgaQPQFQIQRIYTKDLSFENPNAPAIFQEEWQPEVNLNLDTNANKLAEDVYEVVLTVTVTAKLGEKTAFLCEV 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1736062557  79 QQGGIFSISGIEGTQMAHCLGAYCPNILFPYARECITSLVSRGTFPQLNLAPVNFDALFMNYLQQQAGEGTEE 151
Cdd:PRK05751   81 QQAGIFTIRNIPEEQLAPLLGIECPNILFPYAREIIADLVRRGGFPPLNLAPINFDALYEQRLQQAQQAAAEA 153
 
Name Accession Description Interval E-value
PRK05751 PRK05751
preprotein translocase subunit SecB; Validated
1-151 6.20e-94

preprotein translocase subunit SecB; Validated


Pssm-ID: 180234  Cd Length: 156  Bit Score: 268.63  E-value: 6.20e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736062557   1 MSEQNNT--EMAFQIQRIYTKDVSFEAPNAPHVFQKDWQPEVKLDLDTASTQLADDVYEVVLRVTVTASLGEETAFLCEV 78
Cdd:PRK05751    1 MSEQNNTgaQPQFQIQRIYTKDLSFENPNAPAIFQEEWQPEVNLNLDTNANKLAEDVYEVVLTVTVTAKLGEKTAFLCEV 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1736062557  79 QQGGIFSISGIEGTQMAHCLGAYCPNILFPYARECITSLVSRGTFPQLNLAPVNFDALFMNYLQQQAGEGTEE 151
Cdd:PRK05751   81 QQAGIFTIRNIPEEQLAPLLGIECPNILFPYAREIIADLVRRGGFPPLNLAPINFDALYEQRLQQAQQAAAEA 153
secB TIGR00809
protein-export chaperone SecB; This protein acts as an export-specific cytosolic chaperone. It ...
5-147 3.13e-88

protein-export chaperone SecB; This protein acts as an export-specific cytosolic chaperone. It binds the mature region of pre-proteins destined for secretion, prevents aggregation, and delivers them to SecA. This protein is tetrameric in E. coli. The archaeal Methanococcus jannaschii homolog MJ0357 has been shown () to share many properties, including chaperone-like activity, and scores between trusted and noise. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 213561  Cd Length: 140  Bit Score: 253.58  E-value: 3.13e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736062557   5 NNTEMAFQIQRIYTKDVSFEAPNAPHVFQKDWQPEVKLDLDTASTQLADDVYEVVLRVTVTASLGEETAFLCEVQQGGIF 84
Cdd:TIGR00809   1 EEAQPVFQIQRIYVKDLSFEAPNAPHIFQLDWRPEVDLDLDTNSTQLSDDFYEVVLNITVTARLEEYTAFLCEVKQAGVF 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1736062557  85 SISGIEGTQMAHCLGAYCPNILFPYARECITSLVSRGTFPQLNLAPVNFDALFMnylQQQAGE 147
Cdd:TIGR00809  81 NIIGIESEQMAHCLGVHCPNMLFPYAREIISSCVQRGTFPPLNLAPVNFDALYM---QQQMAE 140
SecB COG1952
Preprotein translocase subunit SecB [Intracellular trafficking, secretion, and vesicular ...
1-153 3.73e-86

Preprotein translocase subunit SecB [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 441555  Cd Length: 158  Bit Score: 248.97  E-value: 3.73e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736062557   1 MSEQNN-----TEMAFQIQRIYTKDVSFEAPNAPHVFQKDWQPEVKLDLDTASTQLADDVYEVVLRVTVTASLGEETAFL 75
Cdd:COG1952     1 MAEENNaaqqqQQPQFQIQRQYVKDLSFENPNAPAIFQEQWQPEIDVQLNVNARKLAENVYEVVLTVTVTAKLGDKTAFL 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1736062557  76 CEVQQGGIFSISGIEGTQMAHCLGAYCPNILFPYARECITSLVSRGTFPQLNLAPVNFDALFMNYLQQQAGEGTEEHQ 153
Cdd:COG1952    81 VEVKQAGIFTIRNIPEEQLEPLLGIECPRILFPYAREIVSDLVRRGGFPPLMLAPINFDALYQQRLQQQAAQAAAAQA 158
SecB pfam02556
Preprotein translocase subunit SecB; This family consists of preprotein translocase subunit ...
5-141 6.88e-80

Preprotein translocase subunit SecB; This family consists of preprotein translocase subunit SecB. SecB is required for the normal export of envelope proteins out of the cell cytoplasm.


Pssm-ID: 460589  Cd Length: 137  Bit Score: 232.34  E-value: 6.88e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736062557   5 NNTEMAFQIQRIYTKDVSFEAPNAPHVFQKDWQPEVKLDLDTASTQLADDVYEVVLRVTVTASLGEETAFLCEVQQGGIF 84
Cdd:pfam02556   1 QAQQPQFQIQRQYVKDLSFENPNAPAIFQEQWQPEIDVQLNVNARKLGEGVYEVVLTVTVTAKLGDKTAFLVEVQQAGIF 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1736062557  85 SISGIEGTQMAHCLGAYCPNILFPYARECITSLVSRGTFPQLNLAPVNFDALFMNYL 141
Cdd:pfam02556  81 TIRNVPEEQLEPLLGIECPNILFPYAREIVSDLVRRGGFPPLMLDPINFDALYQQQL 137
Translocase_SecB cd00557
Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit ...
11-139 3.43e-73

Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent polypeptides across the cytoplasmic membrane. SecB has been shown to function as export-specific molecular chaperone that selectively binds preproteins, maintains them in a translocation competent state and delivers them to SecA, the membrane-bound ATPase, that drives the translocation reaction. In solution, SecB exists as homotetramer, which is organized as a dimer of dimers.


Pssm-ID: 238312  Cd Length: 131  Bit Score: 215.07  E-value: 3.43e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736062557  11 FQIQRIYTKDVSFEAPNAPHVFQKDWQPEVKLDLDTASTQLA-DDVYEVVLRVTVTASLG-EETAFLCEVQQGGIFSISG 88
Cdd:cd00557     1 LQIQRIYVKDISFEAPNAPHLFQKDWKPRLNLDLDTEITQLKnDNKYEVVLNITAGAKLEfAKSAFYCEVKQAGVFEIIG 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1736062557  89 IEGTQMAHCLGAYCPNILFPYARECITSLVSRGTFPQLNLAPVNFDALFMN 139
Cdd:cd00557    81 IEIDQMAHCLEINCPAILFPYARELISSITARATFPPLNLPPINFDALFAN 131
 
Name Accession Description Interval E-value
PRK05751 PRK05751
preprotein translocase subunit SecB; Validated
1-151 6.20e-94

preprotein translocase subunit SecB; Validated


Pssm-ID: 180234  Cd Length: 156  Bit Score: 268.63  E-value: 6.20e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736062557   1 MSEQNNT--EMAFQIQRIYTKDVSFEAPNAPHVFQKDWQPEVKLDLDTASTQLADDVYEVVLRVTVTASLGEETAFLCEV 78
Cdd:PRK05751    1 MSEQNNTgaQPQFQIQRIYTKDLSFENPNAPAIFQEEWQPEVNLNLDTNANKLAEDVYEVVLTVTVTAKLGEKTAFLCEV 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1736062557  79 QQGGIFSISGIEGTQMAHCLGAYCPNILFPYARECITSLVSRGTFPQLNLAPVNFDALFMNYLQQQAGEGTEE 151
Cdd:PRK05751   81 QQAGIFTIRNIPEEQLAPLLGIECPNILFPYAREIIADLVRRGGFPPLNLAPINFDALYEQRLQQAQQAAAEA 153
secB TIGR00809
protein-export chaperone SecB; This protein acts as an export-specific cytosolic chaperone. It ...
5-147 3.13e-88

protein-export chaperone SecB; This protein acts as an export-specific cytosolic chaperone. It binds the mature region of pre-proteins destined for secretion, prevents aggregation, and delivers them to SecA. This protein is tetrameric in E. coli. The archaeal Methanococcus jannaschii homolog MJ0357 has been shown () to share many properties, including chaperone-like activity, and scores between trusted and noise. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 213561  Cd Length: 140  Bit Score: 253.58  E-value: 3.13e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736062557   5 NNTEMAFQIQRIYTKDVSFEAPNAPHVFQKDWQPEVKLDLDTASTQLADDVYEVVLRVTVTASLGEETAFLCEVQQGGIF 84
Cdd:TIGR00809   1 EEAQPVFQIQRIYVKDLSFEAPNAPHIFQLDWRPEVDLDLDTNSTQLSDDFYEVVLNITVTARLEEYTAFLCEVKQAGVF 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1736062557  85 SISGIEGTQMAHCLGAYCPNILFPYARECITSLVSRGTFPQLNLAPVNFDALFMnylQQQAGE 147
Cdd:TIGR00809  81 NIIGIESEQMAHCLGVHCPNMLFPYAREIISSCVQRGTFPPLNLAPVNFDALYM---QQQMAE 140
SecB COG1952
Preprotein translocase subunit SecB [Intracellular trafficking, secretion, and vesicular ...
1-153 3.73e-86

Preprotein translocase subunit SecB [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 441555  Cd Length: 158  Bit Score: 248.97  E-value: 3.73e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736062557   1 MSEQNN-----TEMAFQIQRIYTKDVSFEAPNAPHVFQKDWQPEVKLDLDTASTQLADDVYEVVLRVTVTASLGEETAFL 75
Cdd:COG1952     1 MAEENNaaqqqQQPQFQIQRQYVKDLSFENPNAPAIFQEQWQPEIDVQLNVNARKLAENVYEVVLTVTVTAKLGDKTAFL 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1736062557  76 CEVQQGGIFSISGIEGTQMAHCLGAYCPNILFPYARECITSLVSRGTFPQLNLAPVNFDALFMNYLQQQAGEGTEEHQ 153
Cdd:COG1952    81 VEVKQAGIFTIRNIPEEQLEPLLGIECPRILFPYAREIVSDLVRRGGFPPLMLAPINFDALYQQRLQQQAAQAAAAQA 158
SecB pfam02556
Preprotein translocase subunit SecB; This family consists of preprotein translocase subunit ...
5-141 6.88e-80

Preprotein translocase subunit SecB; This family consists of preprotein translocase subunit SecB. SecB is required for the normal export of envelope proteins out of the cell cytoplasm.


Pssm-ID: 460589  Cd Length: 137  Bit Score: 232.34  E-value: 6.88e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736062557   5 NNTEMAFQIQRIYTKDVSFEAPNAPHVFQKDWQPEVKLDLDTASTQLADDVYEVVLRVTVTASLGEETAFLCEVQQGGIF 84
Cdd:pfam02556   1 QAQQPQFQIQRQYVKDLSFENPNAPAIFQEQWQPEIDVQLNVNARKLGEGVYEVVLTVTVTAKLGDKTAFLVEVQQAGIF 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1736062557  85 SISGIEGTQMAHCLGAYCPNILFPYARECITSLVSRGTFPQLNLAPVNFDALFMNYL 141
Cdd:pfam02556  81 TIRNVPEEQLEPLLGIECPNILFPYAREIVSDLVRRGGFPPLMLDPINFDALYQQQL 137
Translocase_SecB cd00557
Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit ...
11-139 3.43e-73

Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent polypeptides across the cytoplasmic membrane. SecB has been shown to function as export-specific molecular chaperone that selectively binds preproteins, maintains them in a translocation competent state and delivers them to SecA, the membrane-bound ATPase, that drives the translocation reaction. In solution, SecB exists as homotetramer, which is organized as a dimer of dimers.


Pssm-ID: 238312  Cd Length: 131  Bit Score: 215.07  E-value: 3.43e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736062557  11 FQIQRIYTKDVSFEAPNAPHVFQKDWQPEVKLDLDTASTQLA-DDVYEVVLRVTVTASLG-EETAFLCEVQQGGIFSISG 88
Cdd:cd00557     1 LQIQRIYVKDISFEAPNAPHLFQKDWKPRLNLDLDTEITQLKnDNKYEVVLNITAGAKLEfAKSAFYCEVKQAGVFEIIG 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1736062557  89 IEGTQMAHCLGAYCPNILFPYARECITSLVSRGTFPQLNLAPVNFDALFMN 139
Cdd:cd00557    81 IEIDQMAHCLEINCPAILFPYARELISSITARATFPPLNLPPINFDALFAN 131
PRK13031 PRK13031
preprotein translocase subunit SecB; Provisional
11-145 1.84e-36

preprotein translocase subunit SecB; Provisional


Pssm-ID: 106068  Cd Length: 149  Bit Score: 122.97  E-value: 1.84e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736062557  11 FQIQRIYTKDVSFEAPNAPHVFQKDWQPEVKLDLDTASTQLADD-VYEVVLRVTVTASLGEETAFLCEVQQGGIFSISGI 89
Cdd:PRK13031    9 FQIQKVYVKDLSFSIPNSDKIWTTNWKPELHTDLKVEATKLPEEnTYETVLTLEVKVENDGMVAFEAEVKQAGIFTVANM 88
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1736062557  90 EGTQMAHCLGAYCPNILFPYARECITSLVSRGTFPQLNLAPVNFDALFMNYLQQQA 145
Cdd:PRK13031   89 QEAQIEHAKKAFCPNILYHYAREAISDLVISGGFPQLCLSAVNFDAMYQDSLKESA 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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