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Conserved domains on  [gi|1743346851|gb|KAA3534152|]
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type VI secretion system membrane subunit TssM [Escherichia coli]

Protein Classification

type VI secretion system membrane subunit( domain architecture ID 11466348)

type VI secretion system membrane subunit such as the IcmF (intracellular multiplication protein F) family protein that exhibits ATPase activity and energizes type VI secretion; it is a conserved T6SS inner membrane protein

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
IcmF COG3523
Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and ...
3-1153 0e+00

Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport];


:

Pssm-ID: 442745 [Multi-domain]  Cd Length: 1192  Bit Score: 1037.22  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851    3 RFKVSAFWLLILAWIFLLVWIWWKGPTWTLYEEQWLKPLANRWLATAAWGIIALMWLTVRVMKRLQQLEKMQKQQREEA- 81
Cdd:COG3523      4 RFLTSRWVLSLLGLLALALLIWFGGPLLAIGDYRPLESVLVRLLAIAVILLLWLLVWLVRRWRARRANRALEDALAEQAe 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851   82 ----VDPLSVELNAQQRYLDRWLLRLQR----YLDNRRFLWQLPWYMVIGPAGSGKTTLLREG---FPSDIIYAPEGARG 150
Cdd:COG3523     84 ekaaADPSREEIEALRERFQEALATLKKsrlgQGGGRRALYELPWYLIIGPPGAGKTTALVNSglkFPLADKFGKAAIRG 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  151 AEQRLYLTPHVGKQAVIFDIDGTLCAPADADILHRRLWEHALGWLKEKRARQPLNGIILTLDLPDLLTADKRRREHLLQT 230
Cdd:COG3523    164 VGGTRNCDWWFTDEAVLIDTAGRYTTQDSDAEVDRAEWLGFLDLLKKHRPRQPINGVIVAISLADLLTQSPEEREQHAKA 243
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  231 LRSRLQDIRQHLHCQLPVYVVLTRLDLLQGFAALFQSLNRQDRDAILGVTFTRRAHENDDWRTELNAFWQTWVDRMNLAL 310
Cdd:COG3523    244 LRQRLQELRERLGIRFPVYVLFTKADLLAGFSEFFADLDKEEREQVWGFTFPYDEKQEFDLLAEFDAEFDELLERLNERL 323
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  311 PDLMVAQT--HTRTSLFSFSRQMQGSREPLVSLLEGLLDGEN--MNVMLRGVYLTSSLQRGQMDDIFTQSAARQYRLGNN 386
Cdd:COG3523    324 LDRLQQERdpERRALIFGFPQQFAALKEALAEFLEELFEPNRyqTPPLLRGVYFTSGTQEGTPIDRVMGALARNFGLSRA 403
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  387 PLASWPlVDTAPYFTRSLFPQALLAEPNLATESRAWLIRSRRRLTVFSATGGVAALLLITGWHHYYNGNYQSGITVLKQA 466
Cdd:COG3523    404 ALPAQS-GSGRSYFLKDLFSKVIFPEAGLAGRNRRWERRRRWLRRAAYAAAALALLGLLGGWTWSYLNNRRLLAEVEAKV 482
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  467 KAFMDVPPPQGEDD-FGNLQLPLLNPVRDATLAYGDWGDRSRL-ADMGLYQGRRIGPYVEQTYLQLLEQRYLPSLFNGLV 544
Cdd:COG3523    483 DAYRALAAALLVADtDLAALLPALNALRDLPAGYGYRRDDPPLsAGLGLYQGDKLGPAARAAYLRALEQLLLPRLALRLE 562
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  545 KAMNAAPPESEEKLAVLRVMRMLEDKSGRNNEVVKQYMAKRWSEKFHGQ--RDIQAQLMSHLDYALAHtdwhaerqaGDG 622
Cdd:COG3523    563 EQLRQAPADPEELYEALKAYLMLGDPEHRDADFLKAWMARDWRELLPGNtrAELRAALERHLDALLDL---------GGD 633
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  623 DAISRWTPYDKPVVSAQKELSKLPVYQRVYQSLKTRALGVLPADLNLRDQVGPTFDQVFTSADDN--KLVVPQFLTRYGL 700
Cdd:COG3523    634 PSAPPLPLDEALVAQARAELRRVPLAQRVYARLKARALATRLPDFTLADAVGPQAALVFTRSSGKplTLGIPGLFTREGY 713
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  701 QSYFVKQRDELVELTAMDSWVLNLTRSVKYSDADRAEIQRQLTEQYISDYTATWRAGMDNLNIRNFESIGQLTGALEQVI 780
Cdd:COG3523    714 HEVFLPAIDELAEELARDDWVLGLSAEDDLSEADREQLQREVRQLYLADYIAEWRAFLGDLRLAPFTSLAQAIAALRVLS 793
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  781 SGDQPLQRALTVLRDNTQPGVFSEKLSAKE--------REEALAEPDYQLL----------------TRLGHEFAPENST 836
Cdd:COG3523    794 SPDSPLRRLLRAVADETTLTRPSEAAAGGAaakgllaaAKARLLSARGRLGrllgadaaaaaaqvpgQPVDRHFAPLHRL 873
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  837 LAVQKDKESTMQAVYQQLTELHRYLLAIQNAPVPGKSALKAVQlrLDQNSSDPIFATRQMAKTLPAPLNRWVGRLTDQAW 916
Cdd:COG3523    874 VEANDGGPAPLDDYLQALNELYTYLTAIANAPDPGKAALKLAK--ASGGGSDLISALKAEAGRLPEPLRRWLGSLADQAW 951
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  917 HVVMVEAVHYMEVDWRDSVVKPFNEQLANNYPFNPRSAQDASLDAFERFFKPDGILDTFYQQNLKLFID---NDLSLEDG 993
Cdd:COG3523    952 SVVLGGARAHLNRRWRAEVYPFCRQAIAGRYPFAPRSSRDVALADFARFFGPGGILDSFFQQNLKPFVDtsgRPWRFRPW 1031
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  994 DNNVI-IREDIIAQLETAQKIRDIFFS-KQNGLGTSFAVETVSLSGNKRRSVLNLDGQLVDYSQGRNYTAHLVWPNNMrE 1071
Cdd:COG3523   1032 DGQGLgLSPAVLAQFQRAAAIRDAFFAgGGAEPSVRFQIKPVSLDPGISRFTLEIDGQLLRYRHGPQRPVSVVWPGPG-G 1110
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851 1072 GNESKLTLIGTSGNAPRSISFSGPWAQFRLFGAGQLTGVQDGNFTVRFSVDGGAMTYRVHTDTEDNPFSGGLFSQFGLSD 1151
Cdd:COG3523   1111 SNGARITLTPLDGTSPSSLSYEGPWALFRLLDKAQLTTVSPDSFTVTFTVDGRSVTYELRADSVNNPFALPLLRGFRCPE 1190

                   ..
gi 1743346851 1152 TL 1153
Cdd:COG3523   1191 SL 1192
 
Name Accession Description Interval E-value
IcmF COG3523
Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and ...
3-1153 0e+00

Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442745 [Multi-domain]  Cd Length: 1192  Bit Score: 1037.22  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851    3 RFKVSAFWLLILAWIFLLVWIWWKGPTWTLYEEQWLKPLANRWLATAAWGIIALMWLTVRVMKRLQQLEKMQKQQREEA- 81
Cdd:COG3523      4 RFLTSRWVLSLLGLLALALLIWFGGPLLAIGDYRPLESVLVRLLAIAVILLLWLLVWLVRRWRARRANRALEDALAEQAe 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851   82 ----VDPLSVELNAQQRYLDRWLLRLQR----YLDNRRFLWQLPWYMVIGPAGSGKTTLLREG---FPSDIIYAPEGARG 150
Cdd:COG3523     84 ekaaADPSREEIEALRERFQEALATLKKsrlgQGGGRRALYELPWYLIIGPPGAGKTTALVNSglkFPLADKFGKAAIRG 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  151 AEQRLYLTPHVGKQAVIFDIDGTLCAPADADILHRRLWEHALGWLKEKRARQPLNGIILTLDLPDLLTADKRRREHLLQT 230
Cdd:COG3523    164 VGGTRNCDWWFTDEAVLIDTAGRYTTQDSDAEVDRAEWLGFLDLLKKHRPRQPINGVIVAISLADLLTQSPEEREQHAKA 243
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  231 LRSRLQDIRQHLHCQLPVYVVLTRLDLLQGFAALFQSLNRQDRDAILGVTFTRRAHENDDWRTELNAFWQTWVDRMNLAL 310
Cdd:COG3523    244 LRQRLQELRERLGIRFPVYVLFTKADLLAGFSEFFADLDKEEREQVWGFTFPYDEKQEFDLLAEFDAEFDELLERLNERL 323
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  311 PDLMVAQT--HTRTSLFSFSRQMQGSREPLVSLLEGLLDGEN--MNVMLRGVYLTSSLQRGQMDDIFTQSAARQYRLGNN 386
Cdd:COG3523    324 LDRLQQERdpERRALIFGFPQQFAALKEALAEFLEELFEPNRyqTPPLLRGVYFTSGTQEGTPIDRVMGALARNFGLSRA 403
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  387 PLASWPlVDTAPYFTRSLFPQALLAEPNLATESRAWLIRSRRRLTVFSATGGVAALLLITGWHHYYNGNYQSGITVLKQA 466
Cdd:COG3523    404 ALPAQS-GSGRSYFLKDLFSKVIFPEAGLAGRNRRWERRRRWLRRAAYAAAALALLGLLGGWTWSYLNNRRLLAEVEAKV 482
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  467 KAFMDVPPPQGEDD-FGNLQLPLLNPVRDATLAYGDWGDRSRL-ADMGLYQGRRIGPYVEQTYLQLLEQRYLPSLFNGLV 544
Cdd:COG3523    483 DAYRALAAALLVADtDLAALLPALNALRDLPAGYGYRRDDPPLsAGLGLYQGDKLGPAARAAYLRALEQLLLPRLALRLE 562
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  545 KAMNAAPPESEEKLAVLRVMRMLEDKSGRNNEVVKQYMAKRWSEKFHGQ--RDIQAQLMSHLDYALAHtdwhaerqaGDG 622
Cdd:COG3523    563 EQLRQAPADPEELYEALKAYLMLGDPEHRDADFLKAWMARDWRELLPGNtrAELRAALERHLDALLDL---------GGD 633
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  623 DAISRWTPYDKPVVSAQKELSKLPVYQRVYQSLKTRALGVLPADLNLRDQVGPTFDQVFTSADDN--KLVVPQFLTRYGL 700
Cdd:COG3523    634 PSAPPLPLDEALVAQARAELRRVPLAQRVYARLKARALATRLPDFTLADAVGPQAALVFTRSSGKplTLGIPGLFTREGY 713
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  701 QSYFVKQRDELVELTAMDSWVLNLTRSVKYSDADRAEIQRQLTEQYISDYTATWRAGMDNLNIRNFESIGQLTGALEQVI 780
Cdd:COG3523    714 HEVFLPAIDELAEELARDDWVLGLSAEDDLSEADREQLQREVRQLYLADYIAEWRAFLGDLRLAPFTSLAQAIAALRVLS 793
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  781 SGDQPLQRALTVLRDNTQPGVFSEKLSAKE--------REEALAEPDYQLL----------------TRLGHEFAPENST 836
Cdd:COG3523    794 SPDSPLRRLLRAVADETTLTRPSEAAAGGAaakgllaaAKARLLSARGRLGrllgadaaaaaaqvpgQPVDRHFAPLHRL 873
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  837 LAVQKDKESTMQAVYQQLTELHRYLLAIQNAPVPGKSALKAVQlrLDQNSSDPIFATRQMAKTLPAPLNRWVGRLTDQAW 916
Cdd:COG3523    874 VEANDGGPAPLDDYLQALNELYTYLTAIANAPDPGKAALKLAK--ASGGGSDLISALKAEAGRLPEPLRRWLGSLADQAW 951
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  917 HVVMVEAVHYMEVDWRDSVVKPFNEQLANNYPFNPRSAQDASLDAFERFFKPDGILDTFYQQNLKLFID---NDLSLEDG 993
Cdd:COG3523    952 SVVLGGARAHLNRRWRAEVYPFCRQAIAGRYPFAPRSSRDVALADFARFFGPGGILDSFFQQNLKPFVDtsgRPWRFRPW 1031
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  994 DNNVI-IREDIIAQLETAQKIRDIFFS-KQNGLGTSFAVETVSLSGNKRRSVLNLDGQLVDYSQGRNYTAHLVWPNNMrE 1071
Cdd:COG3523   1032 DGQGLgLSPAVLAQFQRAAAIRDAFFAgGGAEPSVRFQIKPVSLDPGISRFTLEIDGQLLRYRHGPQRPVSVVWPGPG-G 1110
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851 1072 GNESKLTLIGTSGNAPRSISFSGPWAQFRLFGAGQLTGVQDGNFTVRFSVDGGAMTYRVHTDTEDNPFSGGLFSQFGLSD 1151
Cdd:COG3523   1111 SNGARITLTPLDGTSPSSLSYEGPWALFRLLDKAQLTTVSPDSFTVTFTVDGRSVTYELRADSVNNPFALPLLRGFRCPE 1190

                   ..
gi 1743346851 1152 TL 1153
Cdd:COG3523   1191 SL 1192
VI_IcmF TIGR03348
type VI secretion protein IcmF; Members of this protein family are IcmF homologs and tend to ...
11-1151 0e+00

type VI secretion protein IcmF; Members of this protein family are IcmF homologs and tend to be associated with type VI secretion systems. [Cellular processes, Pathogenesis]


Pssm-ID: 274531 [Multi-domain]  Cd Length: 1169  Bit Score: 893.23  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851   11 LLILAWIFLLVWIWWKGPTWTLYEEQWLKPLANRWLATAAWGIIALMWLTVRVM---KRLQQL-EKMQKQQREEAVDPLS 86
Cdd:TIGR03348    1 LSLLGLILLCILIWWAGPLLAVGDYKPLESVWARLLIIAVLLLVWLLWLLIRQWrarRRNQQLlAALAAPTKLKADAAAE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851   87 VELNAQQRYLDRWLLRLQRY-LDNRRFLWQLPWYMVIGPAGSGKTTLLREG---FP------SDIIYAPEGARGAEQRLy 156
Cdd:TIGR03348   81 AEIRELRARFNEALALLKRSrLGGRRYLYDLPWYLVIGPPGSGKTTLLQNSglkFPlaerlgAAALRGVGGTRNCDWWF- 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  157 ltphvGKQAVIFDIDGTLCAPADADILHRRLWEHALGWLKEKRARQPLNGIILTLDLPDLLTADKRRREHLLQTLRSRLQ 236
Cdd:TIGR03348  160 -----TDEAVLIDTAGRYTTQDSDPEEDAAAWLGFLGLLRKHRRRQPLNGVVVTVSLADLLTADPAERKAHARAIRQRLQ 234
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  237 DIRQHLHCQLPVYVVLTRLDLLQGFAALFQSLNRQDRDAILGVTFTRRAHENDDWRTELNAFWQTWVDRMNLALPDLMVA 316
Cdd:TIGR03348  235 ELREQLGARFPVYLVLTKADLLAGFEEFFADLDAEEREQVWGFTFPLDEADDDNAAEEFAAEFEGLLQRLNARLLERLHQ 314
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  317 QTHT--RTSLFSFSRQMQGSREPLVSLLEGLLDGENM--NVMLRGVYLTSSLQRGQMDDIFTQSAARQYRLgnNPLASWP 392
Cdd:TIGR03348  315 ERDAarRAAIFRFPAQLAALKDRLVQFLEEAFAANRYeeAPLLRGVYFTSATQEGTPIDRLLGALARGFGL--SPGPPAA 392
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  393 LVDTA-PYFTRSLFPQALLAEPNLATESRAWLIRSRRRLTVFSATGGVAALLLITGWHHYYNGNYQSGITVLKQAKAFMD 471
Cdd:TIGR03348  393 ARGEGrSYFLKDLFKEVIFPEAGLAGLNRRAERRRRWLRRGAYAAAALAALGLLGLWSLSYLANRDYLDEVRTQLEAYRA 472
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  472 VPPPQG-EDDFGNLQLPLLNPVRDATLAYGDWGDRSRL-ADMGLYQGRRIGPYVEQTYLQLLEQRYLPSLFNGLVKAMNA 549
Cdd:TIGR03348  473 LAQAIPaAPADVLALLPALDALRDAPLGFGNYDEAPPLlARFGLYQGDKLGEAVRETYLRALQAVLLPRLMQRLEAQLQA 552
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  550 APPESEEKLAVLRVMRMLEDKSGRNNEVVKQYMAKRWSEKFHG--QRDIQAQLMSHLDYALahtdwhaerqAGDGDAISR 627
Cdd:TIGR03348  553 QEQDPEELYETLKVYLMLGDPSRRDADFVKAWFASRWEQQYPGeyQRELREALLGHLRALL----------SLDQDAVPA 622
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  628 WTPYDKPVVSAQKELSKLPVYQRVYQSLKTRALGVLPADLNLRDQVGPTFDQVFTSADDNKL--VVPQFLTRYGLQSYFV 705
Cdd:TIGR03348  623 FPLDDALVEQARAELRAIPLAQRVYQRLKLQPLDAALPDLSLADALGPQADLVFERRSGKPLslGIPGLYTRAGYHDVFL 702
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  706 KQRDELVELTAMDSWVLN-LTRSVKYSDADRAEIQRQLTEQYISDYTATWRAGMDNLNIRNFESIGQLTGALEQVISGDQ 784
Cdd:TIGR03348  703 PQIANLVERALEDAWVLGgASGNSQLSEADRQALAREVRKLYFADYINQWDALLNDLRLKPFESLAQAAALARALASPDS 782
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  785 PLQRALTVLRDNT----------------QPGVFSEKLSAKEREEALAEPDYQLLT---RLGHEFAPENSTLAVQKDKES 845
Cdd:TIGR03348  783 PLARLLRAVARETrltpvdgapadggsnaAAKKLSGLASALGAQLLPAAPGAAALPepgAVERHFEPLRRLLAPNGGPGA 862
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  846 TMQAVYQQLTELHRYLLAIQNAPVPGKSALKAVQlrldQNSSDPIFATRQMAKTLPAPLNRWVGRLTDQAWHVVMVEAVH 925
Cdd:TIGR03348  863 ALDALLAALNELYQQLQALAASPNPGQAALKARM----SGLADALSALRQAAARLPEPLRGWLGSLAADTWKLVLQAARS 938
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  926 YMEVDWRDSVVKPFNEQLANNYPFNPRSAQDASLDAFERFFKPDGILDTFYQQNLKLFID---NDLSLEDGDNNVI-IRE 1001
Cdd:TIGR03348  939 HLNARWQSEVYSFCQQAIAGRYPFSPNSSKDVPLADFERFFGPGGLLDSFFQQNLAPFVDtsaNPWRWKGGDGGSLgISP 1018
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851 1002 DIIAQLETAQKIRDIFF-SKQNGLGTSFAVETVSLSGNKRRSVLNLDGQLVDYSQGRNYTAHLVWPNNMrEGNESKLTLI 1080
Cdd:TIGR03348 1019 SVLAQFQRAARIRDAFFrSGGGEPAVSFTLKPISLDPNIRRFVLEVDGQTLRYAHGPTRPVSLTWPGPN-DGGLARLTLK 1097
                         1130      1140      1150      1160      1170      1180      1190
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1743346851 1081 GTSGNAPRSISFSGPWAQFRLFGAGQLTGVQDGN-FTVRFSVDGGAMTYRVHTDTEDNPFSGGLFSQFGLSD 1151
Cdd:TIGR03348 1098 PADGGSPRTLTFSGPWALFRLLDAGRLTRTGSRDrLDLRFDVGGGAVRYELRAGSADNPFTSGLLSGFRCPG 1169
IcmF-related pfam06761
Intracellular multiplication and human macrophage-killing; This family represents a conserved ...
486-798 1.08e-71

Intracellular multiplication and human macrophage-killing; This family represents a conserved region within several bacterial proteins that resemble IcmF, which has been proposed to be involved in Vibrio cholerae cell surface reorganization, resulting in increased adherence to epithelial cells and increased conjugation frequency. Note that many family members are hypothetical proteins.


Pssm-ID: 429106 [Multi-domain]  Cd Length: 305  Bit Score: 241.48  E-value: 1.08e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  486 LPLLNPVRDATLA--YGDWGDRSRLADMGLYQGRRIGPYVEQTYLQLLEQRYLPSLFNGLVKAMNA-APPESEEKLAVLR 562
Cdd:pfam06761    1 LPALDALRDLPEGllDYYQEGPPLSYRFGLYQGDKLGAAARAAYRRALRQLLLPRLAQRLEAQLRAlAGPDPEALYEALK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  563 VMRMLEDKSGRNNEVVKQYMAKRWSEKFHGQRDIQ--AQLMSHLDYALAHtdwhAERQAGDGDAISRwtpydkpvvsAQK 640
Cdd:pfam06761   81 AYLMLGDPERRDAAFLAAWLTRDWERALPGQATGQqrEALLAHLDALLAD----PPAIPPDAALVAQ----------ARA 146
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  641 ELSKLPVYQRVYQSLKTRALGVLPADLNLRDQVGPTFDQVFTSADDNKL--VVPQFLTRYGLQSYFVKQRDELVELTAMD 718
Cdd:pfam06761  147 TLARVPLAERVYQRLKRQALASALPDFTLADAVGPDAALVFTRSSGKPLseGVPGLFTRAGYHGYFLPALDELAELLLEE 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  719 SWVLNLTRSVKYsDADRAEIQRQLTEQYISDYTATWRAGMDNLNIRNFESIGQLTGALEQVISGDQPLQRALTVLRDNTQ 798
Cdd:pfam06761  227 DWVLGDLAASAL-EADPEQLADDLRELYFTDYAAAWQAFLNDLRLVPFASLAQAIDVLRLLADPDSPLLRLLQAVADETT 305
 
Name Accession Description Interval E-value
IcmF COG3523
Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and ...
3-1153 0e+00

Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442745 [Multi-domain]  Cd Length: 1192  Bit Score: 1037.22  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851    3 RFKVSAFWLLILAWIFLLVWIWWKGPTWTLYEEQWLKPLANRWLATAAWGIIALMWLTVRVMKRLQQLEKMQKQQREEA- 81
Cdd:COG3523      4 RFLTSRWVLSLLGLLALALLIWFGGPLLAIGDYRPLESVLVRLLAIAVILLLWLLVWLVRRWRARRANRALEDALAEQAe 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851   82 ----VDPLSVELNAQQRYLDRWLLRLQR----YLDNRRFLWQLPWYMVIGPAGSGKTTLLREG---FPSDIIYAPEGARG 150
Cdd:COG3523     84 ekaaADPSREEIEALRERFQEALATLKKsrlgQGGGRRALYELPWYLIIGPPGAGKTTALVNSglkFPLADKFGKAAIRG 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  151 AEQRLYLTPHVGKQAVIFDIDGTLCAPADADILHRRLWEHALGWLKEKRARQPLNGIILTLDLPDLLTADKRRREHLLQT 230
Cdd:COG3523    164 VGGTRNCDWWFTDEAVLIDTAGRYTTQDSDAEVDRAEWLGFLDLLKKHRPRQPINGVIVAISLADLLTQSPEEREQHAKA 243
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  231 LRSRLQDIRQHLHCQLPVYVVLTRLDLLQGFAALFQSLNRQDRDAILGVTFTRRAHENDDWRTELNAFWQTWVDRMNLAL 310
Cdd:COG3523    244 LRQRLQELRERLGIRFPVYVLFTKADLLAGFSEFFADLDKEEREQVWGFTFPYDEKQEFDLLAEFDAEFDELLERLNERL 323
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  311 PDLMVAQT--HTRTSLFSFSRQMQGSREPLVSLLEGLLDGEN--MNVMLRGVYLTSSLQRGQMDDIFTQSAARQYRLGNN 386
Cdd:COG3523    324 LDRLQQERdpERRALIFGFPQQFAALKEALAEFLEELFEPNRyqTPPLLRGVYFTSGTQEGTPIDRVMGALARNFGLSRA 403
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  387 PLASWPlVDTAPYFTRSLFPQALLAEPNLATESRAWLIRSRRRLTVFSATGGVAALLLITGWHHYYNGNYQSGITVLKQA 466
Cdd:COG3523    404 ALPAQS-GSGRSYFLKDLFSKVIFPEAGLAGRNRRWERRRRWLRRAAYAAAALALLGLLGGWTWSYLNNRRLLAEVEAKV 482
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  467 KAFMDVPPPQGEDD-FGNLQLPLLNPVRDATLAYGDWGDRSRL-ADMGLYQGRRIGPYVEQTYLQLLEQRYLPSLFNGLV 544
Cdd:COG3523    483 DAYRALAAALLVADtDLAALLPALNALRDLPAGYGYRRDDPPLsAGLGLYQGDKLGPAARAAYLRALEQLLLPRLALRLE 562
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  545 KAMNAAPPESEEKLAVLRVMRMLEDKSGRNNEVVKQYMAKRWSEKFHGQ--RDIQAQLMSHLDYALAHtdwhaerqaGDG 622
Cdd:COG3523    563 EQLRQAPADPEELYEALKAYLMLGDPEHRDADFLKAWMARDWRELLPGNtrAELRAALERHLDALLDL---------GGD 633
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  623 DAISRWTPYDKPVVSAQKELSKLPVYQRVYQSLKTRALGVLPADLNLRDQVGPTFDQVFTSADDN--KLVVPQFLTRYGL 700
Cdd:COG3523    634 PSAPPLPLDEALVAQARAELRRVPLAQRVYARLKARALATRLPDFTLADAVGPQAALVFTRSSGKplTLGIPGLFTREGY 713
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  701 QSYFVKQRDELVELTAMDSWVLNLTRSVKYSDADRAEIQRQLTEQYISDYTATWRAGMDNLNIRNFESIGQLTGALEQVI 780
Cdd:COG3523    714 HEVFLPAIDELAEELARDDWVLGLSAEDDLSEADREQLQREVRQLYLADYIAEWRAFLGDLRLAPFTSLAQAIAALRVLS 793
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  781 SGDQPLQRALTVLRDNTQPGVFSEKLSAKE--------REEALAEPDYQLL----------------TRLGHEFAPENST 836
Cdd:COG3523    794 SPDSPLRRLLRAVADETTLTRPSEAAAGGAaakgllaaAKARLLSARGRLGrllgadaaaaaaqvpgQPVDRHFAPLHRL 873
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  837 LAVQKDKESTMQAVYQQLTELHRYLLAIQNAPVPGKSALKAVQlrLDQNSSDPIFATRQMAKTLPAPLNRWVGRLTDQAW 916
Cdd:COG3523    874 VEANDGGPAPLDDYLQALNELYTYLTAIANAPDPGKAALKLAK--ASGGGSDLISALKAEAGRLPEPLRRWLGSLADQAW 951
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  917 HVVMVEAVHYMEVDWRDSVVKPFNEQLANNYPFNPRSAQDASLDAFERFFKPDGILDTFYQQNLKLFID---NDLSLEDG 993
Cdd:COG3523    952 SVVLGGARAHLNRRWRAEVYPFCRQAIAGRYPFAPRSSRDVALADFARFFGPGGILDSFFQQNLKPFVDtsgRPWRFRPW 1031
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  994 DNNVI-IREDIIAQLETAQKIRDIFFS-KQNGLGTSFAVETVSLSGNKRRSVLNLDGQLVDYSQGRNYTAHLVWPNNMrE 1071
Cdd:COG3523   1032 DGQGLgLSPAVLAQFQRAAAIRDAFFAgGGAEPSVRFQIKPVSLDPGISRFTLEIDGQLLRYRHGPQRPVSVVWPGPG-G 1110
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851 1072 GNESKLTLIGTSGNAPRSISFSGPWAQFRLFGAGQLTGVQDGNFTVRFSVDGGAMTYRVHTDTEDNPFSGGLFSQFGLSD 1151
Cdd:COG3523   1111 SNGARITLTPLDGTSPSSLSYEGPWALFRLLDKAQLTTVSPDSFTVTFTVDGRSVTYELRADSVNNPFALPLLRGFRCPE 1190

                   ..
gi 1743346851 1152 TL 1153
Cdd:COG3523   1191 SL 1192
VI_IcmF TIGR03348
type VI secretion protein IcmF; Members of this protein family are IcmF homologs and tend to ...
11-1151 0e+00

type VI secretion protein IcmF; Members of this protein family are IcmF homologs and tend to be associated with type VI secretion systems. [Cellular processes, Pathogenesis]


Pssm-ID: 274531 [Multi-domain]  Cd Length: 1169  Bit Score: 893.23  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851   11 LLILAWIFLLVWIWWKGPTWTLYEEQWLKPLANRWLATAAWGIIALMWLTVRVM---KRLQQL-EKMQKQQREEAVDPLS 86
Cdd:TIGR03348    1 LSLLGLILLCILIWWAGPLLAVGDYKPLESVWARLLIIAVLLLVWLLWLLIRQWrarRRNQQLlAALAAPTKLKADAAAE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851   87 VELNAQQRYLDRWLLRLQRY-LDNRRFLWQLPWYMVIGPAGSGKTTLLREG---FP------SDIIYAPEGARGAEQRLy 156
Cdd:TIGR03348   81 AEIRELRARFNEALALLKRSrLGGRRYLYDLPWYLVIGPPGSGKTTLLQNSglkFPlaerlgAAALRGVGGTRNCDWWF- 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  157 ltphvGKQAVIFDIDGTLCAPADADILHRRLWEHALGWLKEKRARQPLNGIILTLDLPDLLTADKRRREHLLQTLRSRLQ 236
Cdd:TIGR03348  160 -----TDEAVLIDTAGRYTTQDSDPEEDAAAWLGFLGLLRKHRRRQPLNGVVVTVSLADLLTADPAERKAHARAIRQRLQ 234
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  237 DIRQHLHCQLPVYVVLTRLDLLQGFAALFQSLNRQDRDAILGVTFTRRAHENDDWRTELNAFWQTWVDRMNLALPDLMVA 316
Cdd:TIGR03348  235 ELREQLGARFPVYLVLTKADLLAGFEEFFADLDAEEREQVWGFTFPLDEADDDNAAEEFAAEFEGLLQRLNARLLERLHQ 314
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  317 QTHT--RTSLFSFSRQMQGSREPLVSLLEGLLDGENM--NVMLRGVYLTSSLQRGQMDDIFTQSAARQYRLgnNPLASWP 392
Cdd:TIGR03348  315 ERDAarRAAIFRFPAQLAALKDRLVQFLEEAFAANRYeeAPLLRGVYFTSATQEGTPIDRLLGALARGFGL--SPGPPAA 392
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  393 LVDTA-PYFTRSLFPQALLAEPNLATESRAWLIRSRRRLTVFSATGGVAALLLITGWHHYYNGNYQSGITVLKQAKAFMD 471
Cdd:TIGR03348  393 ARGEGrSYFLKDLFKEVIFPEAGLAGLNRRAERRRRWLRRGAYAAAALAALGLLGLWSLSYLANRDYLDEVRTQLEAYRA 472
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  472 VPPPQG-EDDFGNLQLPLLNPVRDATLAYGDWGDRSRL-ADMGLYQGRRIGPYVEQTYLQLLEQRYLPSLFNGLVKAMNA 549
Cdd:TIGR03348  473 LAQAIPaAPADVLALLPALDALRDAPLGFGNYDEAPPLlARFGLYQGDKLGEAVRETYLRALQAVLLPRLMQRLEAQLQA 552
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  550 APPESEEKLAVLRVMRMLEDKSGRNNEVVKQYMAKRWSEKFHG--QRDIQAQLMSHLDYALahtdwhaerqAGDGDAISR 627
Cdd:TIGR03348  553 QEQDPEELYETLKVYLMLGDPSRRDADFVKAWFASRWEQQYPGeyQRELREALLGHLRALL----------SLDQDAVPA 622
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  628 WTPYDKPVVSAQKELSKLPVYQRVYQSLKTRALGVLPADLNLRDQVGPTFDQVFTSADDNKL--VVPQFLTRYGLQSYFV 705
Cdd:TIGR03348  623 FPLDDALVEQARAELRAIPLAQRVYQRLKLQPLDAALPDLSLADALGPQADLVFERRSGKPLslGIPGLYTRAGYHDVFL 702
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  706 KQRDELVELTAMDSWVLN-LTRSVKYSDADRAEIQRQLTEQYISDYTATWRAGMDNLNIRNFESIGQLTGALEQVISGDQ 784
Cdd:TIGR03348  703 PQIANLVERALEDAWVLGgASGNSQLSEADRQALAREVRKLYFADYINQWDALLNDLRLKPFESLAQAAALARALASPDS 782
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  785 PLQRALTVLRDNT----------------QPGVFSEKLSAKEREEALAEPDYQLLT---RLGHEFAPENSTLAVQKDKES 845
Cdd:TIGR03348  783 PLARLLRAVARETrltpvdgapadggsnaAAKKLSGLASALGAQLLPAAPGAAALPepgAVERHFEPLRRLLAPNGGPGA 862
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  846 TMQAVYQQLTELHRYLLAIQNAPVPGKSALKAVQlrldQNSSDPIFATRQMAKTLPAPLNRWVGRLTDQAWHVVMVEAVH 925
Cdd:TIGR03348  863 ALDALLAALNELYQQLQALAASPNPGQAALKARM----SGLADALSALRQAAARLPEPLRGWLGSLAADTWKLVLQAARS 938
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  926 YMEVDWRDSVVKPFNEQLANNYPFNPRSAQDASLDAFERFFKPDGILDTFYQQNLKLFID---NDLSLEDGDNNVI-IRE 1001
Cdd:TIGR03348  939 HLNARWQSEVYSFCQQAIAGRYPFSPNSSKDVPLADFERFFGPGGLLDSFFQQNLAPFVDtsaNPWRWKGGDGGSLgISP 1018
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851 1002 DIIAQLETAQKIRDIFF-SKQNGLGTSFAVETVSLSGNKRRSVLNLDGQLVDYSQGRNYTAHLVWPNNMrEGNESKLTLI 1080
Cdd:TIGR03348 1019 SVLAQFQRAARIRDAFFrSGGGEPAVSFTLKPISLDPNIRRFVLEVDGQTLRYAHGPTRPVSLTWPGPN-DGGLARLTLK 1097
                         1130      1140      1150      1160      1170      1180      1190
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1743346851 1081 GTSGNAPRSISFSGPWAQFRLFGAGQLTGVQDGN-FTVRFSVDGGAMTYRVHTDTEDNPFSGGLFSQFGLSD 1151
Cdd:TIGR03348 1098 PADGGSPRTLTFSGPWALFRLLDAGRLTRTGSRDrLDLRFDVGGGAVRYELRAGSADNPFTSGLLSGFRCPG 1169
IcmF-related pfam06761
Intracellular multiplication and human macrophage-killing; This family represents a conserved ...
486-798 1.08e-71

Intracellular multiplication and human macrophage-killing; This family represents a conserved region within several bacterial proteins that resemble IcmF, which has been proposed to be involved in Vibrio cholerae cell surface reorganization, resulting in increased adherence to epithelial cells and increased conjugation frequency. Note that many family members are hypothetical proteins.


Pssm-ID: 429106 [Multi-domain]  Cd Length: 305  Bit Score: 241.48  E-value: 1.08e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  486 LPLLNPVRDATLA--YGDWGDRSRLADMGLYQGRRIGPYVEQTYLQLLEQRYLPSLFNGLVKAMNA-APPESEEKLAVLR 562
Cdd:pfam06761    1 LPALDALRDLPEGllDYYQEGPPLSYRFGLYQGDKLGAAARAAYRRALRQLLLPRLAQRLEAQLRAlAGPDPEALYEALK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  563 VMRMLEDKSGRNNEVVKQYMAKRWSEKFHGQRDIQ--AQLMSHLDYALAHtdwhAERQAGDGDAISRwtpydkpvvsAQK 640
Cdd:pfam06761   81 AYLMLGDPERRDAAFLAAWLTRDWERALPGQATGQqrEALLAHLDALLAD----PPAIPPDAALVAQ----------ARA 146
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  641 ELSKLPVYQRVYQSLKTRALGVLPADLNLRDQVGPTFDQVFTSADDNKL--VVPQFLTRYGLQSYFVKQRDELVELTAMD 718
Cdd:pfam06761  147 TLARVPLAERVYQRLKRQALASALPDFTLADAVGPDAALVFTRSSGKPLseGVPGLFTRAGYHGYFLPALDELAELLLEE 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  719 SWVLNLTRSVKYsDADRAEIQRQLTEQYISDYTATWRAGMDNLNIRNFESIGQLTGALEQVISGDQPLQRALTVLRDNTQ 798
Cdd:pfam06761  227 DWVLGDLAASAL-EADPEQLADDLRELYFTDYAAAWQAFLNDLRLVPFASLAQAIDVLRLLADPDSPLLRLLQAVADETT 305
IcmF-related_N pfam14331
IcmF-related N-terminal domain; This domain is found in bacterial IcmF (intracellular ...
184-437 4.94e-59

IcmF-related N-terminal domain; This domain is found in bacterial IcmF (intracellular multiplication and human macrophage-killing) proteins. It is found to the N-terminus of the IcmF-related domain, pfam06761.


Pssm-ID: 433873 [Multi-domain]  Cd Length: 258  Bit Score: 203.61  E-value: 4.94e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  184 HRRLWEHALGWLKEKRARQPLNGIILTLDLPDLLTADKRRREHLLQTLRSRLQDIRQHLHCQLPVYVVLTRLDLLQGFAA 263
Cdd:pfam14331    3 DAAEWLGFLDLLKKHRPRQPINGVLVTVSLADLLSASEEEREAHARALRARLQELRETLGVRFPVYVVLTKADLLAGFDE 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  264 LFQSLNRQDRDAILGVTFTRRAHENDDWRtELNAFWQTWVDRMNLALPDLMVAQ--THTRTSLFSFSRQMQGSREPLVSL 341
Cdd:pfam14331   83 FFADLDREEREQVWGFTFPYDADDEPDAV-LFDQEFDELLERLNARLLDRLQEErdAERRAAIFAFPRQFAALKPRLREF 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851  342 LEGLLDGEN--MNVMLRGVYLTSSLQRGQMDDIFTQSAARQYRLGNNPLASWPlVDTAPYFTRSLFPQALLAEPNLATES 419
Cdd:pfam14331  162 LEELFAPNRyqEAPLLRGVYFTSATQEGTPIDRLAGALARRFGLEAAALPATS-GAGRSYFLHDLFRDVIFPEAGLAGPN 240
                          250
                   ....*....|....*...
gi 1743346851  420 RAWLIRSRRRLTVFSATG 437
Cdd:pfam14331  241 RRWERRRRLLRRAGYAAA 258
IcmF_C pfam06744
Type VI secretion protein IcmF C2-like domain; IcmF_C family represents a conserved region ...
1028-1134 2.28e-26

Type VI secretion protein IcmF C2-like domain; IcmF_C family represents a conserved region situated towards the C-terminal end of IcmF-like proteins. It was thought to be involved in Vibrio cholerae cell surface reorganization that results in increased adherence to epithelial cells leading to an increased conjugation frequency. IcmF as a whole interacts with DotU whereby these bind tightly and form the docking area of the T6SS within the inner membrane. The exact function of this domain is not clear.


Pssm-ID: 429094 [Multi-domain]  Cd Length: 106  Bit Score: 104.34  E-value: 2.28e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743346851 1028 FAVETVSLSGNKRRSVLNLDGQLVDYSQGRNYTAHLVWPNNmREGNESKLTLIGTSGNAPRSISFSGPWAQFRLFGAGQL 1107
Cdd:pfam06744    1 FELRPLPLDPGVTRFVLEIDGQTLRYRHGPSQWTPFSWPGP-RGSPGARLTLTDDDGGTVSTLSYEGPWALFRLLDKAQV 79
                           90       100
                   ....*....|....*....|....*..
gi 1743346851 1108 TGVQDGNFTVRFSVDGGAMTYRVHTDT 1134
Cdd:pfam06744   80 TRTDSDRFRLTFDVDGRKARYELRADS 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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