|
Name |
Accession |
Description |
Interval |
E-value |
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
6-661 |
0e+00 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 716.47 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 6 MLQRLRQISISSSLRGAFLTGALLTLIVSSVSLYSWHEQSSQIRYSLDEYFPRIHAAFLIEGNLNLVVDQLNEFLLAPNT 85
Cdd:COG4192 1 MKKLLKRLGIGARLLLAFALSALLTLVASLVALFSWNSLSNQIRYILDDSLPKLQASLKLEENSNELVAALPEFAAATNT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 86 TVRLQLRNQIIQHLDKIERLSQGLFPAERQQ--LGVILQDSRALLAELDRVLYNMFLVREKVGELAARIDWLHDDFTTEL 163
Cdd:COG4192 81 TERSQLRNQLNTQLADIEELLAELEQLTQDAgdLRAAVADLRNLLQQLDSLLTQRIALRRRLQELLEQINWLHQDFNSEL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 164 NSLVQDFTWQQGTLLDQIEARQgdarqylkRAREVQNEQQQVYTLARIENQIVDDLRDRLnelksGNDDGMLVETHIRYL 243
Cdd:COG4192 161 TPLLQEASWQQTRLLDSVETTE--------SLRNLQNELQLLLRLLAIENQIVSLLREVA-----AARDQADVDNLFDRL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 244 ENLKKTADENIRALDDWPSTITLRQTIDELLEIGMVKNNMPDTMRDYVSAQKALVEASRSREATLGRFRTLLEAQLGSSH 323
Cdd:COG4192 228 QYLKDELDRNLQALKNYPSTITLRQLIDELLAIGSGEGGLPSLRRDELAAQATLEALAEENNSILEQLRTQISGLVGNSR 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 324 QQMQMFNQRMAQIVRVSGGLILVATLLALLLAWGLNHYFIRSRLVKRFSALNQAVVQIGLGRTEATIPVYGRDELGRIAG 403
Cdd:COG4192 308 EQLVALNQETAQLVQQSGILLLAIALLSLLLAVLINYFYVRRRLVKRLNALSDAMAAIAAGDLDVPIPVDGNDEIGRIAR 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 404 LLRHTLGQLNAQKQQLEQEIGERKAIEADLRATQDELIQTAKLAVVGQTMTTLAHEINQPLNALSMYLFTAGRAIEQGQA 483
Cdd:COG4192 388 LLRVFRDQAIEKTQELETEIEERKRIEKNLRQTQDELIQAAKMAVVGQTMTSLAHELNQPLNAMSMYLFSAKKALEQENY 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 484 EQARMTLSKAEGLINRIDAIIRSLRQFTRRAelETPLHPVDLRQTFTVAWELLAMRHKPQQGTLVIPDDtVWIQGDEVRV 563
Cdd:COG4192 468 AQLPTSLDKIEGLIERMDKIIKSLRQFSRKS--DTPLQPVDLRQVIEQAWELVESRAKPQQITLHIPDD-LMVQGDQVLL 544
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 564 HQVLVNVLSNALDACPHAAQITVSWQIQGGRLCVLIADNGPGWPaaLLPSLLKPFTTSKTVGLGIGLSICVSLMTQMEGA 643
Cdd:COG4192 545 EQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWP--LVDKLFTPFTTTKEVGLGLGLSICRSIMQQFGGD 622
|
650
....*....|....*...
gi 1751345881 644 LRLASTFTRSACVVLEFN 661
Cdd:COG4192 623 LYLASTLERGAMVILEFN 640
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
362-660 |
1.46e-55 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 193.48 E-value: 1.46e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 362 FIRSRLVKRFSALNQAVVQIGLGRTEATIPVYGRDELGRIAGLLRHTLGQLNAQKQQLEQEIGERKAIEADLRATQDELI 441
Cdd:COG4191 55 LLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLV 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 442 QTAKLAVVGQTMTTLAHEINQPLNALSMYLFTAGRAIEQ-GQAEQARMTLSKAEGLINRIDAIIRSLRQFTRRAELEtpL 520
Cdd:COG4191 135 QSEKLAALGELAAGIAHEINNPLAAILGNAELLRRRLEDePDPEELREALERILEGAERAAEIVRSLRAFSRRDEEE--R 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 521 HPVDLRQTFTVAWELLAMRHKPQQGTLV--IPDDTVWIQGDEVRVHQVLVNVLSNALDACPHAA--QITVSWQIQGGRLC 596
Cdd:COG4191 213 EPVDLNELIDEALELLRPRLKARGIEVEldLPPDLPPVLGDPGQLEQVLLNLLINAIDAMEEGEggRITISTRREGDYVV 292
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1751345881 597 VLIADNGPGWPAALLPSLLKPFTTSKTV--GLGIGLSICVSLMTQMEGALRLASTFTRSACVVLEF 660
Cdd:COG4191 293 ISVRDNGPGIPPEVLERIFEPFFTTKPVgkGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITL 358
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
361-664 |
1.26e-36 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 142.41 E-value: 1.26e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 361 YFIRSRLVKRFSALNQAVVQIGLGRTEATIPVYGRDELGRIAGLLRHTLGQLNAQKQQLEQ------------------- 421
Cdd:COG5000 27 LLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEQREELEErrryletilenlpagvivl 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 422 ----------------------------------EIGERKAIEADLRATQD----------------------------- 438
Cdd:COG5000 107 dadgritlanpaaerllgipleeligkpleellpELDLAELLREALERGWQeeieltrdgrrtllvrasplrddgyvivf 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 439 ----ELIQTAKLAVVGQTMTTLAHEINQPLNALSMYLFTAGRAIEQGQAEQARMTLSKAEGLINRIDA---IIRSLRQFT 511
Cdd:COG5000 187 dditELLRAERLAAWGELARRIAHEIKNPLTPIQLSAERLRRKLADKLEEDREDLERALDTIIRQVDRlkrIVDEFLDFA 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 512 RRAELEtpLHPVDLRQTFTVAWELLAMRHKPQQGTLV--IPDDTVWIQGDEVRVHQVLVNVLSNALDACPHAAQITVSWQ 589
Cdd:COG5000 267 RLPEPQ--LEPVDLNELLREVLALYEPALKEKDIRLEldLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTR 344
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1751345881 590 IQGGRLCVLIADNGPGWPAALLPSLLKPFTTSKTVGLGIGLSICVSLMTQMEGALRLASTFTRSACVVLEFNLTD 664
Cdd:COG5000 345 REDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAE 419
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
361-663 |
4.40e-35 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 135.81 E-value: 4.40e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 361 YFIRSRLVKRFSALNQAVVQIGLGRTEATIPVYGRDELGRIAGLLRHTLGQLNAQKQQLEQEIGERKAIEADLRATQDEL 440
Cdd:COG0642 23 LLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 441 IQTAKLAVvGQTMTTLAHEINQPLNALSMYLftagRAIEQGQAEQARMTLSKAEGLINRIDAIIRSLRQFTR--RAELET 518
Cdd:COG0642 103 LEEANEAK-SRFLANVSHELRTPLTAIRGYL----ELLLEELDEEQREYLETILRSADRLLRLINDLLDLSRleAGKLEL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 519 PLHPVDLRQTFTVAWELLAMRHKPQQGTLV--IPDDTVWIQGDEVRVHQVLVNVLSNALDACPHAAQITVSWQIQGGRLC 596
Cdd:COG0642 178 EPEPVDLAELLEEVVELFRPLAEEKGIELEldLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVR 257
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1751345881 597 VLIADNGPGWPAALLPSLLKPFTTSKTV----GLGIGLSICVSLMTQMEGALRLASTFTRSACVVLEFNLT 663
Cdd:COG0642 258 ISVEDTGPGIPPEDLERIFEPFFRTDPSrrggGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPLA 328
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
433-660 |
2.80e-34 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 130.80 E-value: 2.80e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 433 LRATQDELIQTAKLAvvGQTMTTLAHEINQPLNALSMYLFTAGRAIEQGQAEQARMtLSKAEGLINRIDAIIRSLRQFTR 512
Cdd:COG2205 2 LEEALEELEELERLK--SEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERREL-LEIIRESAERLLRLIEDLLDLSR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 513 RAELETPLH--PVDLRQTFTVAWELLAMRHKPQQGTLV--IPDDTVWIQGDEVRVHQVLVNVLSNALDACPHAAQITVSW 588
Cdd:COG2205 79 LESGKLSLElePVDLAELLEEAVEELRPLAEEKGIRLEldLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISA 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1751345881 589 QIQGGRLCVLIADNGPGWPAALLPSLLKPF----TTSKTVGLGIGLSICVSLMTQMEGALRLASTFTRSACVVLEF 660
Cdd:COG2205 159 RREGDGVRISVSDNGPGIPEEELERIFERFyrgdNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
421-648 |
3.38e-26 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 110.71 E-value: 3.38e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 421 QEIGERKAIEAdlratqdELIQTAKLAVVGQTMTTLAHEINQPLNALSMYL-FTAGRAIEQGQAEQARMTLSKAEglinR 499
Cdd:COG3852 114 RDITERKRLER-------ELRRAEKLAAVGELAAGLAHEIRNPLTGIRGAAqLLERELPDDELREYTQLIIEEAD----R 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 500 IDAIIRSLRQFTRRAELEtpLHPVDLRQTFTVAWELLAMRHkPQQGTLV--IPDDTVWIQGDEVRVHQVLVNVLSNALDA 577
Cdd:COG3852 183 LNNLVDRLLSFSRPRPPE--REPVNLHEVLERVLELLRAEA-PKNIRIVrdYDPSLPEVLGDPDQLIQVLLNLVRNAAEA 259
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 578 CPHAAQITVS----------WQIQGGRLCVLIADNGPGWPAALLPSLLKPFTTSKTVGLGIGLSICVSLMTQMEGALRLA 647
Cdd:COG3852 260 MPEGGTITIRtrverqvtlgGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTTKEKGTGLGLAIVQKIVEQHGGTIEVE 339
|
.
gi 1751345881 648 S 648
Cdd:COG3852 340 S 340
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
296-660 |
5.96e-25 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 107.33 E-value: 5.96e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 296 ALVEASRSREATLGRFRTLLEAQLGSSHQQMQMFNQRMAQIVRVSGGLILVATLLALLLAWGLNHYFIRSRLVKRFSALN 375
Cdd:COG5002 28 LLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 376 QAVVQIGLGRTEATIPVYGRDELGRIAGLLRHTLGQLNAQKQQLEQEIGERKAIEAdlraTQDELIQTAklavvgqtmtt 455
Cdd:COG5002 108 LALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQ----MRREFVANV----------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 456 lAHEINQPLNALSMYLftagRAIEQGQA---EQARMTLSKAEGLINRIDAIIRSLRQFTR--RAELETPLHPVDLRQTFT 530
Cdd:COG5002 173 -SHELRTPLTSIRGYL----ELLLDGAAddpEERREYLEIILEEAERLSRLVNDLLDLSRleSGELKLEKEPVDLAELLE 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 531 VAWELLAMRHKPQQGTLV--IPDDTVWIQGDEVRVHQVLVNVLSNALDACPHAAQITVSWQIQGGRLCVLIADNGPGWPA 608
Cdd:COG5002 248 EVVEELRPLAEEKGIELEldLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPE 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1751345881 609 ALLPSLLKPF------TTSKTVGLGIGLSICVSLMTQMEGALRLASTFTRSACVVLEF 660
Cdd:COG5002 328 EDLPRIFERFyrvdksRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITL 385
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
558-663 |
2.87e-23 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 95.02 E-value: 2.87e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 558 GDEVRVHQVLVNVLSNALDACPHAAQITVSWQIQGGRLCVLIADNGPGWPAALLPSLLKPFTT-----SKTVGLGIGLSI 632
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRtdkrsRKIGGTGLGLSI 80
|
90 100 110
....*....|....*....|....*....|.
gi 1751345881 633 CVSLMTQMEGALRLASTFTRSACVVLEFNLT 663
Cdd:smart00387 81 VKKLVELHGGEISVESEPGGGTTFTITLPLE 111
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
177-633 |
9.80e-23 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 102.17 E-value: 9.80e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 177 LLDQIEARQGDARQYLKRAREVQNEQQQVYTLARIENQIVDDLRDRLNELKSGNDDGMLVETHIRYLENLKKTADENIRA 256
Cdd:COG4251 19 LLLLLLLLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 257 LDDWPSTITLRQTIDELLEIGMVKNNMPDTMRDYVSAQKALVEASRSREATLGRFRTLLEAQLGSSHQQMQMFNQRMAQI 336
Cdd:COG4251 99 VLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAEL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 337 VRVSGGLILVATLLALLLAWGLNHYFIRSRLVKRFSALNQAVVQIGLGRTEATIPVYGRDELGRIAGLLRHTLGQLNAQK 416
Cdd:COG4251 179 ELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELR 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 417 QQLEQEIGERKAIEADLRATQDELIQTAKLAvvgqtmttlAHEINQPLNALSMYLFTAGRAIEQGQAEQARMTLSKAEGL 496
Cdd:COG4251 259 LELEELEEELEERTAELERSNEELEQFAYVA---------SHDLREPLRKISGFSQLLEEDYGDKLDEEGREYLERIRDA 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 497 INRIDAIIRSLRQFTRRAELETPLHPVDLRQTFTVAWELLAMRHKPQQGTLVIPDDTVwIQGDEVRVHQVLVNVLSNALD 576
Cdd:COG4251 330 AERMQALIDDLLAYSRVGRQELEFEPVDLNELLEEVLEDLEPRIEERGAEIEVGPLPT-VRGDPTLLRQVFQNLISNAIK 408
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1751345881 577 ACP--HAAQITVSWQIQGGRLCVLIADNGPGWPAALLPSLLKPFTTSKTV----GLGIGLSIC 633
Cdd:COG4251 409 YSRpgEPPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRdeyeGTGIGLAIV 471
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
423-660 |
1.71e-21 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 98.12 E-value: 1.71e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 423 IGERKAIEADLRATQdeliqtaKLAVVGQTMTTLAHEINQPLNALSMYLftagRAIEQGQAEQARMTLSKAEGLINRIDA 502
Cdd:COG5809 251 ITERKKLEELLRKSE-------KLSVVGELAAGIAHEIRNPLTSLKGFI----QLLKDTIDEEQKTYLDIMLSELDRIES 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 503 IIRSLRQFTRRAELETplHPVDLRQTFTVAWELL---AMRHKpQQGTLVIPDDTVWIQGDEVRVHQVLVNVLSNALDACP 579
Cdd:COG5809 320 IISEFLVLAKPQAIKY--EPKDLNTLIEEVIPLLqpqALLKN-VQIELELEDDIPDILGDENQLKQVFINLLKNAIEAMP 396
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 580 HAAQITVSWQIQGGRLCVL-IADNGPGWPAALLPSLLKPFTTSKTVGLGIGLSICVSLMTQMEGALRLASTFTRSACVVL 658
Cdd:COG5809 397 EGGNITIETKAEDDDKVVIsVTDEGCGIPEERLKKLGEPFYTTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSI 476
|
..
gi 1751345881 659 EF 660
Cdd:COG5809 477 TL 478
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
563-660 |
2.39e-20 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 86.50 E-value: 2.39e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 563 VHQVLVNVLSNALDACPHAAQITVSWQIQGGRLCVLIADNGPGWPAALLPSLLKPFTTSKTV----GLGIGLSICVSLMT 638
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSreggGTGLGLAIVRRIVE 80
|
90 100
....*....|....*....|..
gi 1751345881 639 QMEGALRLASTFTRSACVVLEF 660
Cdd:cd00075 81 AHGGRITVESEPGGGTTFTVTL 102
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
558-663 |
3.19e-20 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 86.27 E-value: 3.19e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 558 GDEVRVHQVLVNVLSNALDACPHAAQITVSWQiQGGRLCVLIADNGPGWPAALLPSLLKPFTTSKTV---GLGIGLSICV 634
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLS-EGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRgggGTGLGLSIVR 79
|
90 100
....*....|....*....|....*....
gi 1751345881 635 SLMTQMEGALRLASTFTRSACVVLEFNLT 663
Cdd:pfam02518 80 KLVELLGGTITVESEPGGGTTVTLTLPLA 108
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
434-658 |
6.17e-20 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 94.26 E-value: 6.17e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 434 RATQDELIQTAKLAVVGQTMTTLAHEINQPLNALSMYLftagRAIEQGQAEQA-RMTLSKAEGLINRIDAIIRSLRQFTR 512
Cdd:PRK11360 375 KRLQRRVARQERLAALGELVAGVAHEIRNPLTAIRGYV----QIWRQQTSDPPsQEYLSVVLREVDRLNKVIDQLLEFSR 450
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 513 RAELEtpLHPVDLRQTftVAWELLAMRHKPQQGTLVIPDD------TVWIQGDEVRvhQVLVNVLSNALDACPHAAQITV 586
Cdd:PRK11360 451 PRESQ--WQPVSLNAL--VEEVLQLFQTAGVQARVDFETEldnelpPIWADPELLK--QVLLNILINAVQAISARGKIRI 524
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1751345881 587 S-WQIQGGRLCVLIADNGPGWPAALLPSLLKPFTTSKTVGLGIGLSICVSLMTQMEGALRLASTFTRSACVVL 658
Cdd:PRK11360 525 RtWQYSDGQVAVSIEDNGCGIDPELLKKIFDPFFTTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTL 597
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
437-658 |
8.36e-20 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 92.93 E-value: 8.36e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 437 QDELIQTAKLAVVGQTMTTLAHEINQPLNALSMYL-FTAGRAIEQGQAEQARMTLSKAEGLINRIdaiIRSLRQFTRRAE 515
Cdd:PRK10364 225 QDEMKRKEKLVALGHLAAGVAHEIRNPLSSIKGLAkYFAERAPAGGEAHQLAQVMAKEADRLNRV---VSELLELVKPTH 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 516 LEtpLHPVDLRQTFTVAWELLAM--RHKPQQGTLVIPDDTVWIQGDEVRVHQVLVNVLSNALDACPHAAQITVSWQIQGG 593
Cdd:PRK10364 302 LA--LQAVDLNDLINHSLQLVSQdaNSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGA 379
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1751345881 594 RLCVLIADNGPGWPAALLPSLLKPFTTSKTVGLGIGLSICVSLMTQMEGALRLASTFTRSACVVL 658
Cdd:PRK10364 380 GVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTL 444
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
390-664 |
2.60e-19 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 92.78 E-value: 2.60e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 390 IPVYGRDELGRIAGLLRHTLGQLNAQKQQLEQEIGERkaieadlraTQ--DELIQTAKLAVVGQT--MTTLAHEINQPLN 465
Cdd:PRK15347 344 LPENRLDELGSIAKAYNQLLDTLNEQYDTLENKVAER---------TQalAEAKQRAEQANKRKSehLTTISHEIRTPLN 414
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 466 ----ALSMYLFTAGRAIEQGQAEQARM-TLSkaeglinrIDAIIRSLRQFTR----RAEL---ETPLHPVdLRQTF-TVa 532
Cdd:PRK15347 415 gvlgALELLQNTPLTAEQMDLADTARQcTLS--------LLAIINNLLDFSRiesgQMTLsleETALLPL-LDQAMlTI- 484
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 533 wELLAMRHKPQQGTLVIPDDTVWIQGDEVRVHQVLVNVLSNALDACPHaAQITVSWQIQGGRLCVLIADNGPGWPAALLP 612
Cdd:PRK15347 485 -QGPAQSKSLTLRTFVGAHVPLYLHLDSLRLRQILVNLLGNAVKFTET-GGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQ 562
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1751345881 613 SLLKPFTTSKT--VGLGIGLSICVSLMTQMEGALRLASTFTRSACVVLEFNLTD 664
Cdd:PRK15347 563 QIFTPFYQADThsQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLPLNE 616
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
563-659 |
6.70e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 82.12 E-value: 6.70e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 563 VHQVLVNVLSNALDACPHAAQ--ITVSWQIQGGRLCVLIADNGPGWPAALLPSLLKPFTTSKTV--GLGIGLSICVSLMT 638
Cdd:cd16976 1 IQQVLMNLLQNALDAMGKVENprIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVgkGTGLGLSISYGIVE 80
|
90 100
....*....|....*....|.
gi 1751345881 639 QMEGALRLASTFTRSACVVLE 659
Cdd:cd16976 81 EHGGRLSVANEEGAGARFTFD 101
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
421-648 |
1.38e-17 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 86.32 E-value: 1.38e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 421 QEIGERKAIEAdlratqdELIQTAKLAVVGQTMTTLAHEINQPLNALSMY--LFTAGRaieQGQAEQARMTLSKaeglIN 498
Cdd:COG5805 266 RDITEKKEAEE-------LMARSEKLSIAGQLAAGIAHEIRNPLTSIKGFlqLLQPGI---EDKEEYFDIMLSE----LD 331
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 499 RIDAIIRSLRQFTRraELETPLHPVDLRQTFTVAWELL---AMRHKPQQGTLVIpDDTVWIQGDEVRVHQVLVNVLSNAL 575
Cdd:COG5805 332 RIESIISEFLALAK--PQAVNKEKENINELIQDVVTLLeteAILHNIQIRLELL-DEDPFIYCDENQIKQVFINLIKNAI 408
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1751345881 576 DACPHAAQITVSWQIQGGRLCVLIADNGPGWPAALLPSLLKPFTTSKTVGLGIGLSICVSLMTQMEGALRLAS 648
Cdd:COG5805 409 EAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTKEKGTGLGLMVSYKIIENHNGTIDIDS 481
|
|
| PEP_his_kin |
TIGR02916 |
putative PEP-CTERM system histidine kinase; Members of this protein family have a novel ... |
431-658 |
3.53e-14 |
|
putative PEP-CTERM system histidine kinase; Members of this protein family have a novel N-terminal domain, a single predicted membrane-spanning helix, and a predicted cystosolic histidine kinase domain. We designate this protein PrsK, and its companion DNA-binding response regulator protein (TIGR02915) PrsR. These predicted signal-transducing proteins appear to enable enhancer-dependent transcriptional activation. The prsK gene is often associated with exopolysaccharide biosynthesis genes. [Protein fate, Protein and peptide secretion and trafficking, Signal transduction, Two-component systems]
Pssm-ID: 274349 [Multi-domain] Cd Length: 679 Bit Score: 75.91 E-value: 3.53e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 431 ADLRATQdELIQTAKLAVVGQTMTTLAHEINQPLNALSMYLFTAGRAIEQgQAEQARMtLSKAEGLINRIDAIIRSLRqf 510
Cdd:TIGR02916 458 AQMEASE-ALAEARQFEAFNRMSAFVVHDLKNLVAQLSLLLRNAERHKDN-PEFQDDM-LETVENAVNRMKKLLAQLR-- 532
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 511 trRAELETPLHPVDLrqtftVAWELLAMRHKP-QQGTLVIPDDT-VWIQGDEVRVHQVLVNVLSNALDACPHAAQITVSW 588
Cdd:TIGR02916 533 --SKGLEEEKLCVDL-----VDLLRRAIASKRaQGPRPEVSIDTdLSVRADRERLERVLGHLVQNALEATPGEGRVAIRV 605
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1751345881 589 QIQGGRLCVLIADNGPGWPAALLPS-LLKPFTTSKTVGLGIGLSICVSLMTQMEGALRLASTFTRSACVVL 658
Cdd:TIGR02916 606 ERECGAARIEIEDSGCGMSPAFIRErLFKPFDTTKGAGMGIGVYECRQYVEEIGGRIEVESTPGQGTIFTL 676
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
455-627 |
1.33e-13 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 73.73 E-value: 1.33e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 455 TLAHEINQPLNALSmylftaGRA---IEQGQAEQARMTLSKAEGLINRIDAIIRSLRQFTR---RAELETpLHPVDLRQT 528
Cdd:PRK11100 262 TLTHELKSPLAAIR------GAAellQEDPPPEDRARFTGNILTQSARLQQLIDRLLELARleqRQELEV-LEPVALAAL 334
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 529 FTVAWELLAMRHKPQQGTLVIPDDTVWIQGDEVRVHQVLVNVLSNALDACPHAAQITVSWQIQGGRLCVLIADNGPGWPA 608
Cdd:PRK11100 335 LEELVEAREAQAAAKGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPD 414
|
170 180
....*....|....*....|....*.
gi 1751345881 609 ALLP-------SLLKPFTTSKTVGLG 627
Cdd:PRK11100 415 YALPriferfySLPRPANGRKSTGLG 440
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
563-655 |
3.77e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 63.18 E-value: 3.77e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 563 VHQVLVNVLSNALDACPHAA----QITVSWQIQGGR-LCVLIADNGPGWPAALLPSLLKPFTTSKTVGLGIGLSICVSLM 637
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEGGcerrELTIRTSPADDRaVTISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRSII 80
|
90
....*....|....*...
gi 1751345881 638 TQMEGALRLASTFTRSAC 655
Cdd:cd16920 81 EAHGGRLSVESPAGGGAT 98
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
382-660 |
1.15e-11 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 68.17 E-value: 1.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 382 GLGRTEATIPVYgRDELGriagLLRHTLGQLNA--QKQQLEQEigeRKAIEADLRATQdeliqtaKLAVVGQTMTTLAHE 459
Cdd:PRK13837 396 GLGRQRYGLRPP-AGELQ----LLELALDCLAHaiERRRLETE---RDALERRLEHAR-------RLEAVGTLASGIAHN 460
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 460 INQPLNALsmylftagraieQGQAEQARMTLSKAEGLINRIDAIIRS----------LRQFTRRAELetPLHPVDLRQTF 529
Cdd:PRK13837 461 FNNILGAI------------LGYAEMALNKLARHSRAARYIDEIISAgararliidqILAFGRKGER--NTKPFDLSELV 526
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 530 TVAWELLAMRHkPQQGTLVI--PDDTVWIQGDEVRVHQVLVNVLSNALDACPHAAQITVS--------------WQIQGG 593
Cdd:PRK13837 527 TEIAPLLRVSL-PPGVELDFdqDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISlsraklrapkvlshGVLPPG 605
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1751345881 594 RLCVL-IADNGPGWPAALLPSLLKPFTTSKTVGLGIGLSICVSLMTQMEGALRLASTFTRSACVVLEF 660
Cdd:PRK13837 606 RYVLLrVSDTGAGIDEAVLPHIFEPFFTTRAGGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYL 673
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
456-658 |
1.64e-11 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 66.94 E-value: 1.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 456 LAHEINQPLNALSMYLftagrAIEQGQAEQARMTLSKAeglINRIDAIIRSLRQFTR--RAELETPLHPVDLRQTFTVAW 533
Cdd:PRK10604 219 IAHELRTPLVRLRYRL-----EMSDNLSAAESQALNRD---IGQLEALIEELLTYARldRPQNELHLSEPDLPAWLSTHL 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 534 ELLAMRHKPQQGTLVIPDDTVWIQGDEVRVHQVLVNVLSNALDACphAAQITVSWQIQGGRLCVLIADNGPGWPAALLPS 613
Cdd:PRK10604 291 ADIQAVTPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDGNQACLIVEDDGPGIPPEERER 368
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1751345881 614 LLKPFT------TSKTVGLGIGLSICVSLMTQMEGALRLASTFTRSACVVL 658
Cdd:PRK10604 369 VFEPFVrldpsrDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSF 419
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
559-660 |
2.10e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 61.01 E-value: 2.10e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 559 DEVRVHQVLVNVLSNALDACPHAAQITVSWQI-----QGGRLCVLIADNGPGWPAALLPSLLKPFTTSKTVGLGIGLSIC 633
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAIEGRPSDVGEVRIrveadQDGRIVLIVCDNGKGFPREMRHRATEPYVTTRPKGTGLGLAIV 80
|
90 100
....*....|....*....|....*..
gi 1751345881 634 VSLMTQMEGALRLASTFTRSACVVLEF 660
Cdd:cd16944 81 KKIMEEHGGRISLSNREAGGACIRIIL 107
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
434-648 |
5.26e-11 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 65.46 E-value: 5.26e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 434 RATQDELIQTAKLAVVGQTMTTLAHEINQPLNALSMYLFTAGRAIEQGQAEQARMTLS--KAEGLINRIDAIIRSLRQFT 511
Cdd:PRK13557 148 RDAEDALRQAQKMEALGQLTGGIAHDFNNLLQVMSGYLDVIQAALSHPDADRGRMARSveNIRAAAERAATLTQQLLAFA 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 512 RRAELETplHPVDLrQTFTVAWELLAMRhkpqqgTLvipddtvwiqGDEVRVHQV------------------LVNVLSN 573
Cdd:PRK13557 228 RKQRLEG--RVLNL-NGLVSGMGELAER------TL----------GDAVTIETDlapdlwncridptqaevaLLNVLIN 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 574 ALDACPHAAQITVSWQ--------------IQGGR-LCVLIADNGPGWPAALLPSLLKPFTTSKT--VGLGIGLSICVSL 636
Cdd:PRK13557 289 ARDAMPEGGRVTIRTRnveiededlamyhgLPPGRyVSIAVTDTGSGMPPEILARVMDPFFTTKEegKGTGLGLSMVYGF 368
|
250
....*....|..
gi 1751345881 637 MTQMEGALRLAS 648
Cdd:PRK13557 369 AKQSGGAVRIYS 380
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
396-662 |
1.40e-10 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 64.54 E-value: 1.40e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 396 DELGRIAGLLRHTLGQLNAQKQQLEQEIGERKA------IEADLRATQDELIQTAKLAVvgqtMTTLAHEINQPLNA-LS 468
Cdd:PRK11466 389 DTIGRLMDAFRSNVHALNRHREQLAAQVKARTAelqelvIEHRQARAEAEKASQAKSAF----LAAMSHEIRTPLYGiLG 464
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 469 MYLFTAGRAIEQGQAEQARMTLSKAEGLINRIDAIIRSLRQFTRRAELETPLHPVDLRQTFTVAWELLAMRHKPQQGTLV 548
Cdd:PRK11466 465 TAQLLADNPALNAQRDDLRAITDSGESLLTILNDILDYSAIEAGGKNVSVSDEPFEPRPLLESTLQLMSGRVKGRPIRLA 544
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 549 --IPDDT-VWIQGDEVRVHQVLVNVLSNALDACPHAAqITVSWQIQGGRLCVLIADNGPGWPAALLPSLLKPFT--TSKT 623
Cdd:PRK11466 545 tdIADDLpTALMGDPRRIRQVITNLLSNALRFTDEGS-IVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVqvSGKR 623
|
250 260 270
....*....|....*....|....*....|....*....
gi 1751345881 624 VGLGIGLSICVSLMTQMEGALRLASTFTRSACVVLEFNL 662
Cdd:PRK11466 624 GGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPL 662
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
565-648 |
1.89e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 55.51 E-value: 1.89e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 565 QVLVNVLSNALDACPHAAQITVSWQIQGGRLCVLIADNGPGWPAALLPSLLKPFTTSKTV--GLGIGLSICVSLMTQMEG 642
Cdd:cd16943 6 QVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVgeGTGLGLSLSYRIIQKHGG 85
|
....*.
gi 1751345881 643 ALRLAS 648
Cdd:cd16943 86 TIRVAS 91
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
563-658 |
2.78e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 54.74 E-value: 2.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 563 VHQVLVNVLSNALDACphAAQITVSWQIQGGRLCVLIADNGPGWPAALLPSLLKPFT------TSKTVGLGIGLSICVSL 636
Cdd:cd16939 1 MARALDNLLRNALRYA--HRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVrldpsrDRATGGFGLGLAIVHRV 78
|
90 100
....*....|....*....|..
gi 1751345881 637 MTQMEGALRLASTFTRSACVVL 658
Cdd:cd16939 79 ALWHGGHVECDDSELGGACFRL 100
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
565-648 |
5.88e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 54.31 E-value: 5.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 565 QVLVNVLSNALDACPHAAQITVSWQIQ---------------GGRLCVLIADNGPGWPAALLPSLLKPFTTSKTV--GLG 627
Cdd:cd16919 3 LAILNLAVNARDAMPEGGRLTIETSNQrvdadyalnyrdlipGNYVCLEVSDTGSGMPAEVLRRAFEPFFTTKEVgkGTG 82
|
90 100
....*....|....*....|.
gi 1751345881 628 IGLSICVSLMTQMEGALRLAS 648
Cdd:cd16919 83 LGLSMVYGFVKQSGGHLRIYS 103
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
565-642 |
6.29e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 53.94 E-value: 6.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 565 QVLVNVLSNALDACPH-----------AAQITVSWQIQGGRLCVLIADNGPGWPAALLPSLLKPFTTSKTVGLGIGLSIC 633
Cdd:cd16918 3 QVFLNLVRNAAQALAGsggeiilrtrtQRQVTLGHPRHRLALRVSVIDNGPGIPPDLQDTIFYPMVSGRENGTGLGLAIA 82
|
....*....
gi 1751345881 634 VSLMTQMEG 642
Cdd:cd16918 83 QNIVSQHGG 91
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
559-660 |
6.45e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 54.00 E-value: 6.45e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 559 DEVRVHQVLVNVLSNALDACPHAAQITVSWQIQGGRLCVLIADNGPGWPAALLPSLLKPFTTSKTVG-----LGIGLSIC 633
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRrsgghYGMGLYIA 80
|
90 100
....*....|....*....|....*..
gi 1751345881 634 VSLMTQMEGALRLASTFTRSACVVLEF 660
Cdd:cd16975 81 KNLVEKHGGSLIIENSQKGGAEVTVKI 107
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
565-651 |
1.15e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 53.27 E-value: 1.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 565 QVLVNVLSNALDACPHAaQITVSWQIQG-----GRLCVLIADNGPGWPAALLPSLLKPF------TTSKTVGLGIGLSIC 633
Cdd:cd16922 3 QILLNLLGNAIKFTEEG-EVTLRVSLEEeeedgVQLRFSVEDTGIGIPEEQQARLFEPFsqadssTTRKYGGTGLGLAIS 81
|
90 100
....*....|....*....|....
gi 1751345881 634 VSLMTQMEGALRLAS------TFT 651
Cdd:cd16922 82 KKLVELMGGDISVESepgqgsTFT 105
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
565-647 |
3.17e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 51.68 E-value: 3.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 565 QVLVNVLSNALDacpHAA-QITVSWQIQGGRLCVLIADNGPGWPAALLPSLLKPFT----TSKTVGLGIGLSICVSLMTQ 639
Cdd:cd16950 3 RVLSNLVDNALR---YGGgWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYrgdnARGTSGTGLGLAIVQRISDA 79
|
....*...
gi 1751345881 640 MEGALRLA 647
Cdd:cd16950 80 HGGSLTLA 87
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
563-659 |
3.39e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 51.82 E-value: 3.39e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 563 VHQVLVNVLSNALDACPHAAQITVSWQI--QGGRLCVliADNGPGWPAALLPSLLKPF------TTSKTVGLGIGLSICV 634
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQeeSGARLSV--EDTGPGIPPEHIPRLTERFyrvdieRCRNTGGTGLGLAIVK 78
|
90 100
....*....|....*....|....*...
gi 1751345881 635 SLMTQMEGALRLASTF---TRSACVVLE 659
Cdd:cd16952 79 HVMSRHDARLLIASELgkgSRFTCLFPS 106
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
550-642 |
4.96e-08 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 56.52 E-value: 4.96e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 550 PDDTVWIQGDEVRVHQVLVNVLSNALDACpHAAQITVSWQIQGGRLCVLIADNGPGWPAALLPSLLKPF------TTSKT 623
Cdd:PRK10841 550 PDVPVALNGDPMRLQQVISNLLSNAIKFT-DTGCIVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFfqvgtgVQRNF 628
|
90
....*....|....*....
gi 1751345881 624 VGLGIGLSICVSLMTQMEG 642
Cdd:PRK10841 629 QGTGLGLAICEKLINMMDG 647
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
546-633 |
6.85e-08 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 55.81 E-value: 6.85e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 546 TLVIPDDTVWIQGDEVRVHQVLVNVLSNALDACPHAAQITVSWQIQGGRLCVLIADNGPGWPAALLPSLLKPFT----TS 621
Cdd:PRK10490 762 NLSLPEPLTLIHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFArgnkES 841
|
90
....*....|..
gi 1751345881 622 KTVGLGIGLSIC 633
Cdd:PRK10490 842 AIPGVGLGLAIC 853
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
425-648 |
8.17e-08 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 54.70 E-value: 8.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 425 ERKAIEADLRATQdELIQTAKLAVVGQTMTTLAHEINQPLNALSMYLFTAGRAI-EQGQAEQARMTLSKAEGLINRIDAI 503
Cdd:PRK11073 107 EMAPMDNQRRLSQ-EQLQHAQQVAARDLVRGLAHEIKNPLGGLRGAAQLLSKALpDPALTEYTKVIIEQADRLRNLVDRL 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 504 IRSLRQFTRRAEletPLHPVDLRQTFTVAWELlamrhkPQQGTLV------IPDdtvwIQGDEVRVHQVLVNVLSNALDA 577
Cdd:PRK11073 186 LGPQRPGTHVTE---SIHKVAERVVQLVSLEL------PDNVRLIrdydpsLPE----LAHDPDQIEQVLLNIVRNALQA 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 578 CPH-----------AAQITvswqIQGGRlCVLIA-----DNGPGWPAALLPSLLKPFTTSKTVGLGIGLSICVSLMTQME 641
Cdd:PRK11073 253 LGPeggtitlrtrtAFQLT----LHGER-YRLAAridieDNGPGIPPHLQDTLFYPMVSGREGGTGLGLSIARNLIDQHS 327
|
....*..
gi 1751345881 642 GALRLAS 648
Cdd:PRK11073 328 GKIEFTS 334
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
564-645 |
8.67e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 50.79 E-value: 8.67e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 564 HQVLVNVLSNALDACPhaAQITVSWQIQGGRLCVLIADNGPGWPAALLPSLLKPF------TTSKTVGLGIGLSICVSLM 637
Cdd:cd16949 2 ARALENVLRNALRYSP--SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFyrvdsaRDRESGGTGLGLAIAERAI 79
|
....*...
gi 1751345881 638 TQMEGALR 645
Cdd:cd16949 80 EQHGGKIK 87
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
457-658 |
1.92e-07 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 53.43 E-value: 1.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 457 AHEINQPLNALSMYLftagRAIEQGQAEQARMtlskaegLINRIDAIIRSLRQFTRRAELETPL-----HPVDLRQTFTV 531
Cdd:PRK10755 145 AHELRTPLAGIRLHL----ELLEKQHHIDVAP-------LIARLDQMMHTVEQLLQLARAGQSFssghyQTVKLLEDVIL 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 532 AW-----ELLAMRHkpQQGTLVIPDDTVWIQGDEVRVHQVLVNVLSNALDACPHAAQITVSWQIQGGRLCVLIADNGPGW 606
Cdd:PRK10755 214 PSqdelsEMLEQRQ--QTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVEDEGPGI 291
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1751345881 607 PAALLPSLLKPFT--TSKTVGLGIGLSIcVSLMTQM-EGALRLASTFTRS---ACVVL 658
Cdd:PRK10755 292 DESKCGELSKAFVrmDSRYGGIGLGLSI-VSRITQLhHGQFFLQNRQERSgtrAWVWL 348
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
451-633 |
5.05e-07 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 52.26 E-value: 5.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 451 QTMTTLAHEINQPLNALSMylftagrAIEQGQAEQARMTLSKAEGLINR-----------IDAIIRSLRQFTRRAELETP 519
Cdd:PRK09303 153 RVLAMLAHDLRTPLTAASL-------ALETLELGQIDEDTELKPALIEQlqdqarrqleeIERLITDLLEVGRTRWEALR 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 520 LHP--VDLRQTFTVAWELLAMRHKPQQGTLV--IPDDTVWIQGDEVRVHQVLVNVLSNALDACPHAAQITV------SWQ 589
Cdd:PRK09303 226 FNPqkLDLGSLCQEVILELEKRWLAKSLEIQtdIPSDLPSVYADQERIRQVLLNLLDNAIKYTPEGGTITLsmlhrtTQK 305
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1751345881 590 IQggrlcVLIADNGPGWPAA----------LLPSllkpftTSKTVGLGIGLSIC 633
Cdd:PRK09303 306 VQ-----VSICDTGPGIPEEeqerifedrvRLPR------DEGTEGYGIGLSVC 348
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
389-664 |
7.15e-07 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 52.16 E-value: 7.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 389 TIPVYGRDE-LGRIAGLLRHTlgQLNAQKQQLEQEigeRKAIEAdLRAtqdeliqtaklavvgqtmttLAHEINQPLNAL 467
Cdd:COG3290 154 RVPIRDDGRvVGAVATFRDRT--ELERLEEELEGV---KELAEA-LRA--------------------QRHDFRNHLHTI 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 468 SMYlftagraIEQGQAEQARMTLSKaegLINRIDAIIRSLRQFTRRAELetplhpvdlrQTFTVAWELLAMRHKPQqgtL 547
Cdd:COG3290 208 SGL-------LQLGEYDEALEYIDE---ISEELQELIDSLLSRIGNPVL----------AALLLGKAARARERGID---L 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 548 VIpDDTVWIQGDEVRVHQVLV---NVLSNALDAC----PHAAQITVSWQIQGGRLCVLIADNGPGWPAALLPSLLKP-FT 619
Cdd:COG3290 265 TI-DIDSDLPDLPLSDTDLVTilgNLLDNAIEAVeklpEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERgFS 343
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1751345881 620 TSKTVGLGIGLSICVSLMTQMEGALRLASTFTRSACVVLEFNLTD 664
Cdd:COG3290 344 TKLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEG 388
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
458-632 |
1.60e-06 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 51.16 E-value: 1.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 458 HEINQPLNALSMYL-FTAGRAIEQGQAEQARMTLSKAeglINRIDAIIRSLRQFTRraeLET-PLHpvDLRQTFTVAW-- 533
Cdd:PRK11006 213 HELRTPLTVLQGYLeMMQDQPLEGALREKALHTMREQ---TQRMEGLVKQLLTLSK---IEAaPTI--DLNEKVDVPMml 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 534 -----ELLAMRHKPQQGTLVIpDDTVWIQGDEVRVHQVLVNVLSNALDACPHAAQITVSWQ--IQGGRLCVliADNGPGW 606
Cdd:PRK11006 285 rvlerEAQTLSQGKHTITFEV-DNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQrvPQGAEFSV--EDNGPGI 361
|
170 180 190
....*....|....*....|....*....|..
gi 1751345881 607 PAALLPSLLKPF------TTSKTVGLGIGLSI 632
Cdd:PRK11006 362 APEHIPRLTERFyrvdkaRSRQTGGSGLGLAI 393
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
565-644 |
2.12e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 46.80 E-value: 2.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 565 QVLVNVLSNALDACP-HAAQITVSWQIQGGRLCVLIADNGPGWPAALLPSLLKPFTTSKTVGL------GIGLSICVSLM 637
Cdd:cd16953 3 QVLRNLIGNAISFSPpDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEafgqhsGLGLSISRQII 82
|
....*..
gi 1751345881 638 TQMEGAL 644
Cdd:cd16953 83 EAHGGIS 89
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
362-646 |
5.47e-06 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 49.14 E-value: 5.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 362 FIRsRLVKRFSALNQAVVQIGLGRTEATIPVYGRDELGRIAgllrHTLGQLNAQKQQLEQEigerkaieadlRAtqdeLI 441
Cdd:PRK09467 173 FIR-IQNRPLVALEHAALQVGKGEIPPPLREYGASEVRSVT----RAFNQMAAGIKQLEDD-----------RT----LL 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 442 qtaklavvgqtMTTLAHEINQPLnalsmylfTAGR-AIEQGQAEQARMtlskAEGLINRI---DAIIRslrQFTR--RAE 515
Cdd:PRK09467 233 -----------MAGVSHDLRTPL--------TRIRlATEMMSEEDGYL----AESINKDIeecNAIIE---QFIDylRTG 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 516 LETPLHPVDLRqtfTVAWELLAMRHKPQ-QGTLVIPDDTVWIQGDEVRVHQVLVNVLSNALDAcpHAAQITVSWQIQGGR 594
Cdd:PRK09467 287 QEMPMEMADLN---ALLGEVIAAESGYErEIETALQPGPIEVPMNPIAIKRALANLVVNAARY--GNGWIKVSSGTEGKR 361
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 1751345881 595 LCVLIADNGPGWPAALLPSLLKPFTTSKT----VGLGIGLSICVSLMTQMEGALRL 646
Cdd:PRK09467 362 AWFQVEDDGPGIPPEQLKHLFQPFTRGDSargsSGTGLGLAIVKRIVDQHNGKVEL 417
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
553-643 |
1.38e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 44.70 E-value: 1.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 553 TVWIQGDEVRVHQVLVNVLSNALDACPHAAQITVSWQIQGGRLcVLIADNGPGWPAALLPSLLKPFTTS---KTVGLGIG 629
Cdd:cd16940 4 DIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAV-IRVEDNGPGIDEEELEALFERFYRSdgqNYGGSGLG 82
|
90
....*....|....
gi 1751345881 630 LSIcVSLMTQMEGA 643
Cdd:cd16940 83 LSI-VKRIVELHGG 95
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
569-658 |
4.13e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 43.04 E-value: 4.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 569 NVLSNALDA-----CPHAaQITVSWQIQGGRLCVLIADNGPGWPAALLPSLL-KPFTTSKTVGLGIGLSICVSLMTQMEG 642
Cdd:cd16915 7 NLIDNALDAlaatgAPNK-QVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFeRGVSTKGQGERGIGLALVRQSVERLGG 85
|
90
....*....|....*.
gi 1751345881 643 ALRLASTFTRSACVVL 658
Cdd:cd16915 86 SITVESEPGGGTTFSI 101
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
565-647 |
6.54e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 42.45 E-value: 6.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 565 QVLVNVLSNALDACPHAAQITVSWQIQGGRLCVLIADNGPGWPAALLP-------SLLKPFTTSKTVGLgiGLSICVSLM 637
Cdd:cd16945 7 QAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNrvferfySLPRPHSGQKSTGL--GLAFVQEVA 84
|
90
....*....|
gi 1751345881 638 TQMEGALRLA 647
Cdd:cd16945 85 QLHGGRITLR 94
|
|
| HATPase_YpdA-YehU-LytS-like |
cd16924 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
565-630 |
7.22e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 42.43 E-value: 7.22e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1751345881 565 QVLV-NVLSNALDACPHAAQITVSWQIQGGRLCVLIADNGPGWPAALLPSLLKpfttSKTVGLGIGL 630
Cdd:cd16924 7 QPLVeNAIQHGLSPLTDKGVVTISALKEDNHVMIEVEDNGRGIDPKVLNILGK----KPKEGNGIGL 69
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
456-648 |
9.81e-05 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 45.53 E-value: 9.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 456 LAHEINQPLNALsmylftagraieqgqAEQARMTLSKAEGLINRIDAIIRSLRQFTRRAEL-----------ETPLHP-- 522
Cdd:PRK09835 269 IAHEIRTPITNL---------------ITQTEIALSQSRSQKELEDVLYSNLEELTRMAKMvsdmlflaqadNNQLIPek 333
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 523 --VDLRQTFTVAWELLAMRHKPQQGTLVIPDDTVWIQGDEVRVHQVLVNVLSNALDACPHAAQITVSWQIQGGRLCVLIA 600
Cdd:PRK09835 334 kmLDLADEVGKVFDFFEAWAEERGVELRFVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVE 413
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1751345881 601 DNGPGWPAALLPSL------LKPFTTSKTVGLGIGLSICVSLMTQMEGALRLAS 648
Cdd:PRK09835 414 NPGTPIAPEHLPRLfdrfyrVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTS 467
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
407-648 |
1.82e-04 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 44.73 E-value: 1.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 407 HTLGQLNAQKQQLE----QEIGERKAIEADLRATQDELIQTAklAVVGQTMTTLAHEINQPLNALSMYL-FTAGRAIEQG 481
Cdd:PRK09959 668 HTLCNLPASDHAVYicgwQDITETRDLIHALEVERNKAINAT--VAKSQFLATMSHEIRTPISSIMGFLeLLSGSGLSKE 745
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 482 Q-AEQARMTLSKAEGLINRIDAIIRSLRQFTRRAELETPLH--PVDLRQTFTVAWELLAMRHKPQQGTLVIPDDTVwIQG 558
Cdd:PRK09959 746 QrVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVdiPTLVQNTCHSFGAIAASKSIALSCSSTFPDHYL-VKI 824
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 559 DEVRVHQVLVNVLSNALDACPHAA-QITVSW-QIQGGRLCV--LIADNGPGWPAALLPSLLKPFTTS----KTVGLGIGL 630
Cdd:PRK09959 825 DPQAFKQVLSNLLSNALKFTTEGAvKITTSLgHIDDNHAVIkmTIMDSGSGLSQEEQQQLFKRYSQTsagrQQTGSGLGL 904
|
250
....*....|....*...
gi 1751345881 631 SICVSLMTQMEGALRLAS 648
Cdd:PRK09959 905 MICKELIKNMQGDLSLES 922
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
539-660 |
2.83e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 41.46 E-value: 2.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 539 RHKPQQGTLVIPDDTVWI--QGDevrvhqvLVNVLSNALD-ACPHA-AQITVSWQIQGGRLCVLIADNGPGWPAALLPSL 614
Cdd:cd16954 15 QRKGVSISLDISPELRFPgeRND-------LMELLGNLLDnACKWClEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKI 87
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1751345881 615 LKPFTTSKTV--GLGIGLSICVSLMTQMEGALRLASTFTRSACVVLEF 660
Cdd:cd16954 88 FQRGQRLDEQrpGQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
563-656 |
2.93e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 40.77 E-value: 2.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 563 VHQVLVNVLSNAL---DACPHAaQITVSWQIQGGRLCVLIADNGPGWPAALLPSLLKPF----TTSKTVGLGIGLSICVS 635
Cdd:cd16921 1 LGQVLTNLLGNAIkfrRPRRPP-RIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFqrlhSREEYEGTGVGLAIVRK 79
|
90 100
....*....|....*....|.
gi 1751345881 636 LMTQMEGALRLASTFTRSACV 656
Cdd:cd16921 80 IIERHGGRIWLESEPGEGTTF 100
|
|
| HAMP |
pfam00672 |
HAMP domain; |
362-414 |
6.04e-04 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 37.99 E-value: 6.04e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1751345881 362 FIRSRLVKRFSALNQAVVQIGLGRTEATIPVYGRDELGRIAGLLRHTLGQLNA 414
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
450-512 |
6.23e-04 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 38.35 E-value: 6.23e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1751345881 450 GQTMTTLAHEINQPLNALSMYLFTagrAIEQGQAEQARMTLSKAEGLINRIDAIIRSLRQFTR 512
Cdd:pfam00512 3 SEFLANLSHELRTPLTAIRGYLEL---LRDEKLDEEQREYLETILRSAERLLRLINDLLDLSR 62
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
446-512 |
8.07e-04 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 38.35 E-value: 8.07e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1751345881 446 LAVVGQTMTTLAHEINQPLNALSMYLFTAGRaiEQGQAEQARMTLSKAEGLINRIDAIIRSLRQFTR 512
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEE--ELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
546-648 |
8.48e-04 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 42.59 E-value: 8.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 546 TLVIPDDTVWIQ-GDEVRVHQ---VLVNVLSNALDACPHAA--QITVSWQIQGGRLCVLIADNGPGWPAALLPSLLKPFT 619
Cdd:PRK11086 413 TLIISEDSQLPDsGDEDQVHElitILGNLIENALEAVGGEEggEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGY 492
|
90 100
....*....|....*....|....*....
gi 1751345881 620 TSKTVGLGIGLSICVSLMTQMEGALRLAS 648
Cdd:PRK11086 493 STKGSNRGVGLYLVKQSVENLGGSIAVES 521
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
366-415 |
1.06e-03 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 37.61 E-value: 1.06e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 1751345881 366 RLVKRFSALNQAVVQIGLGRTEATIPVYGRDELGRIAGLLRHTLGQLNAQ 415
Cdd:smart00304 2 RLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEET 51
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
571-630 |
1.23e-03 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 39.51 E-value: 1.23e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1751345881 571 LSNALDacpHA------AQITVSWQIQGGRLCVLIADNGPGWPAALLPsllKPFTTSKTVGLGIGL 630
Cdd:COG2172 43 VTNAVR---HAyggdpdGPVEVELELDPDGLEIEVRDEGPGFDPEDLP---DPYSTLAEGGRGLFL 102
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
555-669 |
1.27e-03 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 41.85 E-value: 1.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 555 WIQGDEVRVHQVLVNVLSNALDACpHAAQITVS-WQIQGGRLCVLIADNGPGWPAAllpSLLKPFT----------TSKT 623
Cdd:PRK11091 391 KVITDGTRLRQILWNLISNAVKFT-QQGGVTVRvRYEEGDMLTFEVEDSGIGIPED---ELDKIFAmyyqvkdshgGKPA 466
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1751345881 624 VGLGIGLSICVSLMTQMEGALRLASTFTRSACVVLEFNLTDVKDVE 669
Cdd:PRK11091 467 TGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIHAPAVAEEV 512
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
361-631 |
1.85e-03 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 41.16 E-value: 1.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 361 YFIRSRLVKRFSALNQAVVQIGLGRTeATIPVYGRDELGRIAGLLRHTLGQLNAQKQQLEQEigERKAIEADLRAtqdel 440
Cdd:COG2972 175 YLLSRSITRPIKRLKKAMKKVEKGDL-VRLEVSGNDEIGILARSFNEMVERIKELIEEVYEL--ELEKKEAELKA----- 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 441 iqtaklavvgqtmttLAHEINqP------LNALSMYlftagrAIEQGQAEQARMTLSkaegLINRIDAIIRSLRQF-TRR 513
Cdd:COG2972 247 ---------------LQAQIN-PhflfntLNSIRWL------AELEDPEEAEEMLEA----LSKLLRYSLSKGDELvTLE 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 514 AELETplhpvdLRQTFtvawELLAMRHKPQ-QGTLVIPDDTvwiqgDEVRVH----QVLV-NVLSNALDACPHAAQITVS 587
Cdd:COG2972 301 EELEL------IKSYL----EIQKLRFGDRlEVEIEIDEEL-----LDLLIPklilQPLVeNAIEHGIEPKEGGGTIRIS 365
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 1751345881 588 WQIQGGRLCVLIADNGPGWPAALLPSLLKPFtTSKTVGLGIGLS 631
Cdd:COG2972 366 IRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-SSKGEGRGIGLR 408
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
559-644 |
3.07e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 37.83 E-value: 3.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 559 DEVRVHQVLVNVLSNALDACP-------HAAQITVSWQIqggrlcvLIADNGPGWPAALLPSLLKPF------TTSKTVG 625
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDtggklriRAAQTPQEVRL-------DVEDSAPGVSDDQLARLFERFyrvessRNRASGG 73
|
90
....*....|....*....
gi 1751345881 626 LGIGLSICVSLMTQMEGAL 644
Cdd:cd16946 74 SGLGLAICHNIALAHGGTI 92
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
163-514 |
4.48e-03 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 40.00 E-value: 4.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 163 LNSLVQDFTWQQGTLLDQIEARQGDARQYLKRAREVQNEQQQVYTLARIENQIVDDLRDRLNELKSGNDDGMLVETHIRY 242
Cdd:COG0840 5 LLLLALLLALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLAL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 243 LENLKKTADENIRALDDwpsTITLRQTIDELLEIGMVKNNMPDTMRDYVSAQKALVEASRSREATLGRFRTLLEAQLGSS 322
Cdd:COG0840 85 LLALLLLLLALLALALA---ALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 323 HQQMQMFNQRMAQIVRVSGGLILVATLLALLLAWGLNHYFIRSRLVKRFSALNQAVVQIGLGRTEATIPVYGRDELGRIA 402
Cdd:COG0840 162 ALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 403 GLLRHTLGQLNAQKQQLEQEIGERKAIEADLRATQDEL-----IQTAKLAVVGQTMTTLAHEINQplnalsmylfTAGRA 477
Cdd:COG0840 242 DAFNRMIENLRELVGQVRESAEQVASASEELAASAEELaagaeEQAASLEETAAAMEELSATVQE----------VAENA 311
|
330 340 350
....*....|....*....|....*....|....*...
gi 1751345881 478 IE-QGQAEQARMTLSKAEGLINRIDAIIRSLRQFTRRA 514
Cdd:COG0840 312 QQaAELAEEASELAEEGGEVVEEAVEGIEEIRESVEET 349
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
408-613 |
5.16e-03 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 39.22 E-value: 5.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 408 TLGQLNAQKQQLEQEIgERKAIEADLRATQDELiqtAKLA-----VVGQTMTtlaheinqplnALSMYLFTAGRAIEQgQ 482
Cdd:COG4585 23 ALVLLRARRAERAAEL-ERELAARAEEAREEER---RRIArelhdGVGQSLS-----------AIKLQLEAARRLLDA-D 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 483 AEQARMTLSKAEGLInriDAIIRSLRQFTRRaeletpLHPVDL-RQTFTVAWELLAMRHKPQQGTLVipddTVWIQGDEV 561
Cdd:COG4585 87 PEAAREELEEIRELA---REALAELRRLVRG------LRPPALdDLGLAAALEELAERLLRAAGIRV----ELDVDGDPD 153
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1751345881 562 RVHQV------------LVNVLSNAldacpHAAQITVSWQIQGGRLCVLIADNGPGWPAALLPS 613
Cdd:COG4585 154 RLPPEvelalyrivqeaLTNALKHA-----GATRVTVTLEVDDGELTLTVRDDGVGFDPEAAPG 212
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
457-632 |
5.88e-03 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 39.63 E-value: 5.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 457 AHEINQPLNALSMYLFTAGRAIEQGQA-EQARMTLSKAeglINRIDAIIRSLRQFTRRAELETP--LHPVDLRQTFTVAw 533
Cdd:PRK10337 245 AHELRSPLAALKVQTEVAQLSDDDPQArKKALLQLHAG---IDRATRLVDQLLTLSRLDSLDNLqdVAEIPLEDLLQSA- 320
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 534 eLLAMRHKPQQG----TLVIPDDTVWIQGDEVRVHQVLVNVLSNALDACPHAAQITVSWQIQGGRlcvlIADNGPGWPAA 609
Cdd:PRK10337 321 -VMDIYHTAQQAgidvRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARNFT----VRDNGPGVTPE 395
|
170 180
....*....|....*....|....*..
gi 1751345881 610 LLPSL----LKPFTTSKTvGLGIGLSI 632
Cdd:PRK10337 396 ALARIgerfYRPPGQEAT-GSGLGLSI 421
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
450-512 |
6.48e-03 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 35.62 E-value: 6.48e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1751345881 450 GQTMTTLAHEINQPLNALSMYlftAGRAIEQGQAEQARMTLSKAEGLINRIDAIIRSLRQFTR 512
Cdd:smart00388 3 REFLANLSHELRTPLTAIRGY---LELLLDTELSEEQREYLETILREAERLLRLINDLLDLSR 62
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
569-645 |
7.73e-03 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 39.15 E-value: 7.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751345881 569 NVLSNALDACPHaaQITVSWQIQGGRLCVLIADNGPGWPAALLPSLLKPF------TTSKTVGLGIGLSICVSLMTQMEG 642
Cdd:PRK09470 360 NIVRNALRYSHT--KIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFyrvdeaRDRESGGTGLGLAIVENAIQQHRG 437
|
...
gi 1751345881 643 ALR 645
Cdd:PRK09470 438 WVK 440
|
|
| |
