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Conserved domains on  [gi|1752644444|gb|KAA9223560|]
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MFS transporter [Acinetobacter baumannii]

Protein Classification

MFS transporter( domain architecture ID 13023516)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

Gene Ontology:  GO:0022857|GO:0005886|GO:0016020|GO:0055085
PubMed:  26098515|26758938
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 18-387 2.24e-58

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 194.69  E-value: 2.24e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  18 IFIMAMTCGICAGSNYYNQPLIYSIAEALKVNADQVALTIVISQLSYAVGLFILVPLGDFFEKRSYICLLMCCTGFAQVG 97
Cdd:cd17324     1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  98 LSLSQTLPALYGFTFLATFF-SIATQVLVPFAAGLASPKKSPQVVGTLMSGLFLGILLARSIAGLLSTVWSWHAVYLISG 176
Cdd:cd17324    81 AALAPSFALLLLARALAGLAhGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 177 IVILVFAWVMWVKLPVARKSHQLNILqiYGSLFSLAVHQPHLLRRGLAGGIGFGILALIFTTMTFILANEPYHFNDFQIG 256
Cdd:cd17324   161 VLALLAALLLWRLLPSLPPKKPGSLG--LLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 257 LFGIVGLAGVFATPWAGKkIAAGLENKIAVICMGLLMSAWIPLFFAQQSLVAYAVGVIMAYFGLSAFHVLNQNLVYRISA 336
Cdd:cd17324   239 LLLLFGVAGVVGSPLAGR-LADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP 317

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1752644444 337 EARSRINSIYMTLYFGGAALGSFIAVYAWKHWGWEACAILGLGLAMLSFLI 387
Cdd:cd17324   318 EARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLL 368
 
Name Accession Description Interval E-value
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 18-387 2.24e-58

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 194.69  E-value: 2.24e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  18 IFIMAMTCGICAGSNYYNQPLIYSIAEALKVNADQVALTIVISQLSYAVGLFILVPLGDFFEKRSYICLLMCCTGFAQVG 97
Cdd:cd17324     1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  98 LSLSQTLPALYGFTFLATFF-SIATQVLVPFAAGLASPKKSPQVVGTLMSGLFLGILLARSIAGLLSTVWSWHAVYLISG 176
Cdd:cd17324    81 AALAPSFALLLLARALAGLAhGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 177 IVILVFAWVMWVKLPVARKSHQLNILqiYGSLFSLAVHQPHLLRRGLAGGIGFGILALIFTTMTFILANEPYHFNDFQIG 256
Cdd:cd17324   161 VLALLAALLLWRLLPSLPPKKPGSLG--LLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 257 LFGIVGLAGVFATPWAGKkIAAGLENKIAVICMGLLMSAWIPLFFAQQSLVAYAVGVIMAYFGLSAFHVLNQNLVYRISA 336
Cdd:cd17324   239 LLLLFGVAGVVGSPLAGR-LADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP 317

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1752644444 337 EARSRINSIYMTLYFGGAALGSFIAVYAWKHWGWEACAILGLGLAMLSFLI 387
Cdd:cd17324   318 EARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLL 368
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
18-356 2.25e-29

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 116.61  E-value: 2.25e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  18 IFIMAMTCGICAGSNYYNQPLIYSIAEALKVNADQVALTIVISQLSYAVGLFILVPLGDFFEKRSYICLLMCCTGFAQVG 97
Cdd:COG2814    12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  98 LSLSQTLPALYGFTFL-ATFFSIATQVLVPFAAGLASPKKSPQVVGTLMSGLFLGILLARSIAGLLSTVWSWHAVYLISG 176
Cdd:COG2814    92 CALAPSLWLLLAARFLqGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNA 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 177 IVILVFAWVMWVKLPVARKSHQLNILQIYGSLFSlavhQPHLLRRGLAGGIGFGILALIFTTMTFILAnEPYHFNDFQIG 256
Cdd:COG2814   172 VLALLALLLLLRLLPESRPAARARLRGSLRELLR----RPRLLLLLLLAFLLGFGFFALFTYLPLYLQ-EVLGLSASAAG 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 257 LFGIVGLAGVFATPWAGKKIAAGLENKIAVICMGLLMSAWIPLFFAQQSLVAYAVGVIMAYFGLSAFHVLNQNLVYRIS- 335
Cdd:COG2814   247 LLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAp 326

                         330       340
                  ....*....|....*....|.
gi 1752644444 336 AEARSRINSIYMTLYFGGAAL 356
Cdd:COG2814   327 PEARGRASGLYNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
20-358 1.95e-17

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 82.85  E-value: 1.95e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  20 IMAMTCGICAGSNYYNQPLIYSIAEALKVNADQVALTIVISQLSYAVGLFILVPLGDFFEKRSYICLLMCCTGFAQVGLS 99
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 100 LSQTLPALYGFTFLATFF-SIATQVLVPFAAGLASPKKSPQVVGTLMSGLFLGILLARSIAGLLSTVWSWHAVYLISGIV 178
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGaGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 179 ILVFAWVMWVKLPVARKSHQLNILQIYGSLFSLAVHQPHLLRRGLAGGIGFGILALIFTTMTFILANEPYHFNDFQ---- 254
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLagll 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 255 IGLFGIVGLAGVFATPWAGKKIAAGLENKIAVICMGLLMSAWIPLFFAQQSLVAYAVGVIMAYFGLSAFHVLNQNLVYRI 334
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320

                         330       340
                  ....*....|....*....|....
gi 1752644444 335 SAEARSRINSIYMTLYFGGAALGS 358
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGALGP 344
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
37-230 8.45e-07

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 50.68  E-value: 8.45e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  37 PLIYSIAEALKVNADQVALTIVISQLSYAVGLFILVPLGDFFEKRSYICLLMCCTGFAQVGLSLSQTLPALYGFTFLATF 116
Cdd:PRK11102   12 PALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 117 FSIATQVlvpfaaglaspkkspqVVGTLMSGLF-----------------LGILLARSIAGLLSTVWSWHAV-YLISGIV 178
Cdd:PRK11102   92 AAAAASV----------------VINALMRDMFpkeefsrmmsfvtlvmtIAPLLAPIIGGWLLVWFSWHAIfWVLALAA 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1752644444 179 ILVFAWVMWV---KLPVARKS--HQLNILQIYGSLFSlavhQPHLLRRGLAGGIGFG 230
Cdd:PRK11102  156 ILAAALVFFFipeTLPKERRQpfHLRTTIRNFASLFR----HKRVLGYMLASGFSFA 208
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 65-191 8.12e-06

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 47.74  E-value: 8.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  65 AVGLFILVPLGDFFEKRsyICLLMCCTGFA--QVGLSLSQTLPALYGFTFLATF-FSIATQVLVPFAAGLASPKKSPQVV 141
Cdd:TIGR00895  66 AFGALFFGPLADRIGRR--RVLLWSILLFSvfTLLCALATNVTQLLILRFLAGLgLGGLMPNLNALVSEYAPKRFRGTAV 143

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1752644444 142 GTLMSGLFLGILLARSIAGLLSTVWSWHAVYLISGIVILVFAWVMWVKLP 191
Cdd:TIGR00895 144 GLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLP 193
 
Name Accession Description Interval E-value
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 18-387 2.24e-58

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 194.69  E-value: 2.24e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  18 IFIMAMTCGICAGSNYYNQPLIYSIAEALKVNADQVALTIVISQLSYAVGLFILVPLGDFFEKRSYICLLMCCTGFAQVG 97
Cdd:cd17324     1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  98 LSLSQTLPALYGFTFLATFF-SIATQVLVPFAAGLASPKKSPQVVGTLMSGLFLGILLARSIAGLLSTVWSWHAVYLISG 176
Cdd:cd17324    81 AALAPSFALLLLARALAGLAhGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 177 IVILVFAWVMWVKLPVARKSHQLNILqiYGSLFSLAVHQPHLLRRGLAGGIGFGILALIFTTMTFILANEPYHFNDFQIG 256
Cdd:cd17324   161 VLALLAALLLWRLLPSLPPKKPGSLG--LLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 257 LFGIVGLAGVFATPWAGKkIAAGLENKIAVICMGLLMSAWIPLFFAQQSLVAYAVGVIMAYFGLSAFHVLNQNLVYRISA 336
Cdd:cd17324   239 LLLLFGVAGVVGSPLAGR-LADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP 317

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1752644444 337 EARSRINSIYMTLYFGGAALGSFIAVYAWKHWGWEACAILGLGLAMLSFLI 387
Cdd:cd17324   318 EARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLL 368
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
18-356 2.25e-29

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 116.61  E-value: 2.25e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  18 IFIMAMTCGICAGSNYYNQPLIYSIAEALKVNADQVALTIVISQLSYAVGLFILVPLGDFFEKRSYICLLMCCTGFAQVG 97
Cdd:COG2814    12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  98 LSLSQTLPALYGFTFL-ATFFSIATQVLVPFAAGLASPKKSPQVVGTLMSGLFLGILLARSIAGLLSTVWSWHAVYLISG 176
Cdd:COG2814    92 CALAPSLWLLLAARFLqGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNA 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 177 IVILVFAWVMWVKLPVARKSHQLNILQIYGSLFSlavhQPHLLRRGLAGGIGFGILALIFTTMTFILAnEPYHFNDFQIG 256
Cdd:COG2814   172 VLALLALLLLLRLLPESRPAARARLRGSLRELLR----RPRLLLLLLLAFLLGFGFFALFTYLPLYLQ-EVLGLSASAAG 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 257 LFGIVGLAGVFATPWAGKKIAAGLENKIAVICMGLLMSAWIPLFFAQQSLVAYAVGVIMAYFGLSAFHVLNQNLVYRIS- 335
Cdd:COG2814   247 LLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAp 326

                         330       340
                  ....*....|....*....|.
gi 1752644444 336 AEARSRINSIYMTLYFGGAAL 356
Cdd:COG2814   327 PEARGRASGLYNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
20-358 1.95e-17

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 82.85  E-value: 1.95e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  20 IMAMTCGICAGSNYYNQPLIYSIAEALKVNADQVALTIVISQLSYAVGLFILVPLGDFFEKRSYICLLMCCTGFAQVGLS 99
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 100 LSQTLPALYGFTFLATFF-SIATQVLVPFAAGLASPKKSPQVVGTLMSGLFLGILLARSIAGLLSTVWSWHAVYLISGIV 178
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGaGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 179 ILVFAWVMWVKLPVARKSHQLNILQIYGSLFSLAVHQPHLLRRGLAGGIGFGILALIFTTMTFILANEPYHFNDFQ---- 254
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLagll 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 255 IGLFGIVGLAGVFATPWAGKKIAAGLENKIAVICMGLLMSAWIPLFFAQQSLVAYAVGVIMAYFGLSAFHVLNQNLVYRI 334
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320

                         330       340
                  ....*....|....*....|....
gi 1752644444 335 SAEARSRINSIYMTLYFGGAALGS 358
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGALGP 344
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 37-387 3.37e-17

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 82.24  E-value: 3.37e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  37 PLIYSIAEALKVNADQVALTIVISQLSYAVGLFILVPLGDFFEKRSYICLLMCCTGFAQVGLSLSQTLPALYGFTFLATF 116
Cdd:cd17325    17 PILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 117 FSIATQVLV-PFAAGLASPKKSPQVVGTLMSGLFLGILLARSIAGLLSTVWSWHAVYLISGIVILVFAWVMWVKLPVARK 195
Cdd:cd17325    97 ASAAVWPAAmALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRP 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 196 SH--QLNILQIYGSLFSLAVHQPHLLRRGLAGGIGFGILALIFTTMtFILANEPYHFNDFQIGL-FGIVGLAGVFATPWA 272
Cdd:cd17325   177 PPnkRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFL-PLYAAELGGLSPAQIGLlFGAQGLASALSQPPA 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 273 GKKIAAGLENKIAVICMgLLMSAWIPLFFAQQSLVAYAVGVIMAYFGLSAFHVLNQNLV-YRISAEARSRINSIYMTLYF 351
Cdd:cd17325   256 GKLSDRIGRKPLILIGL-LLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLaDIVPPEGRGTAMGLFNTAFS 334

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1752644444 352 GGAALGSFIAVYAWKHWGWEACAILGLGLAMLSFLI 387
Cdd:cd17325   335 LGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVL 370
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 37-387 2.70e-15

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 76.84  E-value: 2.70e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  37 PLIYSIAEALKVNADQVALTIVISQLSYAVGLFILVPLGDFFEKRSYICLLMCCTGFAQVGLSLSQTLPALYGFTFL--- 113
Cdd:cd17474    20 PILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALqgi 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 114 --ATFFSIATQVLVPFAAGlaspKKSPQVVGTLMSGLFLGILLARSIAGLLSTvWSWHAVYLISGIVILVFAWVMWVKLP 191
Cdd:cd17474   100 gaAGLGPLALTLIGDLFEG----GERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLAALIPVAFLAILFLLP 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 192 VaRKSHQLNILQIYGSLFSLAVHQPHLLRRGLAGGIGFGILALIFTTMTFILANEpYHFNDFQIGL-FGIVGLAGVFATP 270
Cdd:cd17474   175 E-PKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELL-YGISPIIIGLlFAGWSVLLALGSL 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 271 WAGKKIAAGLENKIAVICMGLLMSAWIPLFFAQQSLVAYAVGVIMAYFGLSAFHVLNQNLVYRIS-AEARSRINSIYMTL 349
Cdd:cd17474   253 FVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELApEEERGTASSLYNFV 332

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1752644444 350 YFGGAALGSFIAVYAWKHWGWEACAILGLGLAMLSFLI 387
Cdd:cd17474   333 RFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVL 370
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 37-387 9.86e-15

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 74.92  E-value: 9.86e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  37 PLIYSIAEALKVNADQVALTIVISQLSYAVGLFILVPLGDFFEKRSYICLLMCCTGFAQVGLSLSQTLPALYGFTFLATF 116
Cdd:cd17320    20 PALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGL 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 117 FSIATQVLVP-FAAGLASPKKSPQVVGTLMSGLFLGILLARSIAGLLSTVWSWHAVYLI-SGIVILVFAWVMWV---KLP 191
Cdd:cd17320   100 GAAAGSVVARaIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFlALLGLLLLLLVLLFlpeTLP 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 192 V-ARKSHQLNILQIYGSLFSlavhQPHLLRRGLAGGIGFGILALIFTTMTFILANEpYHFNDFQIGLF----GIVGLAGV 266
Cdd:cd17320   180 EeKRKPLLSSLLRAYKRVLK----NRRFLGYALALGLSFAGLFAYLAAAPFIYIEQ-LGLSPAQFGLLfalnAIALILGS 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 267 FATPWAGKKIAAGLENKIAVICMGLLMSAWIPLFFAQQ-SLVAYAVGVIMAYFGLSAFHVLNQNLVYRISAEARSRINSI 345
Cdd:cd17320   255 LLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGlSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASAL 334

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1752644444 346 YMTLYFGGAALGSFIAVYAWKHWGW-EACAILGLGLAMLSFLI 387
Cdd:cd17320   335 LGFLQFLIGALAGALVGLLPNGTALpMGLLILVLGLLALLLLI 377
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 49-387 1.28e-13

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 71.88  E-value: 1.28e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  49 NADQVALTIVISQLSYAVGLFILVPLGDFFEKR-----SYICLLMCCTGFAQVGLSLSQTLPALYGFTFL----ATFFSI 119
Cdd:cd06173    32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRrllilADLLRALLAAVLALLALLGSLSLWLLLVLAFLlgiaSAFFGP 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 120 ATQVLVPfaaGLASPKKSPQVVGTLMSGLFLGILLARSIAGLLSTVWSWHAVYLISGIVILVFAWVMW-VKLPVARKSHQ 198
Cdd:cd06173   112 ARQALLP---ELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLfIRRPPPAAPGE 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 199 LNILQIYGSLFSLA-VHQPHLLRRGLAGGIGFGILALIFTTMTFILANEPYHFNDFQIG-LFGIVGLAGVFATPWAGKKI 276
Cdd:cd06173   189 SSSLLLRDLREGLRyLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGlLLAAFGVGALLGALLLGRLS 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 277 AAGLENKIAVICMGLLMSAWIPLFFAQQSLVAYAVGVIMAyFGLSAFHVLNQNLVYRISAEA-RSRINSIYMTLYFGGAA 355
Cdd:cd06173   269 KRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLG-LAGGLFNVPLNTLLQLRVPDElRGRVFSVYNALNSGAMP 347

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1752644444 356 LGSFIAVYAWKHWGWEACAILGLGLAMLSFLI 387
Cdd:cd06173   348 LGALLAGLLADALGLSAVFLLAGALLLLAALL 379
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
37-389 7.78e-12

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 66.44  E-value: 7.78e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  37 PLIYSIAEALKVNADQVALTIVISQLSYAVGLFILVPLGDFFEKRSYICLLMCCTGFAQVGLSLSQTLPALYGFTFLATF 116
Cdd:COG2807    39 PLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGA 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 117 FSIATQVLVPFAAGLASPKKSPQVVGTLMSGLFLGILLARSIAGLLSTVWSWHAVYLISGIVILVFAWVMWVKLPVARKS 196
Cdd:COG2807   119 GIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAA 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 197 HQLNilqiygslfSLAVHQPHLLRRGLAGGIG--FGILALIFTTMTFILanePYHFNDFQI---------GLFGIVGLAG 265
Cdd:COG2807   199 AAAA---------PAAASLRSLWRSPLAWLLTlfFGLQSLLYYAVVAWL---PPILRDAGLsaataglllSLFQLAGIPG 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 266 VFATPWAGKKIAAglENKIAVICMGLLMSAWIPLFFAQQSLVAYAVGVI-MAYFGLSAFHVLNQNLVYRISAEArSRINS 344
Cdd:COG2807   267 SLLVPLLADRLGD--RRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLgLGQGGLFPLALTLIGLRARTPAEA-AALSG 343

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1752644444 345 IYMTLYFGGAALGSFIAVYAWKHWG-----WEACAILGLGLAMLSFLIDR 389
Cdd:COG2807   344 MAQSVGYLLAALGPLLVGALHDATGswtaaLLLLAALAVLMLVAGLLAGR 393
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
17-387 1.71e-11

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 64.89  E-value: 1.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  17 FIFIMAMTCGICAGSNYYNQPLIY-SIAEALKVNADQVALTIVISQLSYAVGLFILVPLGDFFEKRSYICLLMCCTGFAQ 95
Cdd:COG2271    10 RILALLFLAYFLNYLDRSNLSVAApPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  96 VGLSLSQTLPALYGFTFLATFF-SIATQVLVPFAAGLASPKKSPQVVGTLMSGLFLGILLARSIAGLLSTVWSWHAVYLI 174
Cdd:COG2271    90 LLFGFATSFWQLLLLRFLLGLGeAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLI 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 175 SGIVILVFAWVMwvklpvarkshqlnilqiygslfslavhqphlLRRGLAGGIGFGILALIFTTMTFILANEPYHFNDFQ 254
Cdd:COG2271   170 LGLPGLLLALLR--------------------------------FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQ 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 255 IG----LFGIVGLAGVFATPWAGKKIAAGlENKIAVICMGLLMSAWIPLFFAQQSLVAYAVGVIMAYFGLSAFHVLNQNL 330
Cdd:COG2271   218 AGlllsLPFLAGIVGSLLGGWLSDRLGRR-RKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALA 296

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1752644444 331 VYRISAEARSRINSIYMTLYFGGAALGSFIAVYAWKHWGWEACAILGLGLAMLSFLI 387
Cdd:COG2271   297 AELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALL 353
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
18-387 1.07e-10

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 62.59  E-value: 1.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  18 IFIMAMTCGICAGSNYYNQPLIYSIAEALKVNADQVALTIVISQLSYAVGLFILVPLGDFFEKRSYICLLMCCTGFAQVG 97
Cdd:COG2223     7 LLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  98 LSLSQTLPALYGFTFLATFFSIAT-QVLVPFAAGLASPKKSPQVVGTLMSGLFLGILLARSIAGLLSTVWSWHAVYLISG 176
Cdd:COG2223    87 LALAVSYWLLLLLGLLLGIGGGGSfAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILG 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 177 IVILVFAWVMWVKLPVARKSHQLNILQIYGSLFSlAVHQPHLLRRGLAGGIGFGILALIFTTMTFILANEpYHFNDFQIG 256
Cdd:COG2223   167 ILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLE-ALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQ-FGLSAATAG 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 257 ----LFGIVGLAGVFATPWAGKKIAAGlenKIAVICMGLLMSAWIPLFFAQQSLVAYAVGVIMAYFGLSAFHVLNQNLVY 332
Cdd:COG2223   245 llaaLFALLGALGRPLGGWLSDRIGGR---RVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVP 321

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1752644444 333 RI-SAEARSRINSIYMTLYFGGAALGSFIAVYAWKHWG-WEACAILGLGLAMLSFLI 387
Cdd:COG2223   322 DIfPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVL 378
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 17-267 6.13e-09

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 57.20  E-value: 6.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  17 FIFIMAMTCGICAGSNYYnqPLIYSIAEALKVNADQVALTIVISQLSYAVGLFILVPLGDFF-EKRSYIC--LLMCCtgf 93
Cdd:cd17323     2 FIISFLTFVVTFGSSIYS--PALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYgRRPVYLVslFIFVI--- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  94 AQVGLSLSQTLPALYGFTFLATFFSIATQVLVPFAAG-LASPKKSPQVVGTLMSGLFLGILLARSIAGLLSTVWSWHAVY 172
Cdd:cd17323    77 FQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIAdLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIF 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 173 LISGIVILVFAWVMWVKLPVArkshqlnilqiygSLFSLAVhqphllrrglagGIGFGILALIFTTMTFILAnEPYHFND 252
Cdd:cd17323   157 WFLAIISGFCLILIFLFLPIV-------------LLLGLYV------------GLVYAILYLFLTAFPYVFG-EVYGFSP 210

                         250
                  ....*....|....*
gi 1752644444 253 FQIGLFGIVGLAGVF 267
Cdd:cd17323   211 GEVGLMYLPIGIGAL 225
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 36-387 5.19e-08

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 54.35  E-value: 5.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  36 QPLIYSIAEALKVNADQVALTIVISQLSYAVGLFILVPLGDFFEKRSYICLLMCCTGFAQVGLSLSQTLPALYGFTFLAT 115
Cdd:cd06174    16 SPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLG 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 116 FFSIATQVLVP-FAAGLASPKKSPQVVGTLMSGLFLGILLARSIAGLL--STVWSWHAVYLISGIVILVFAWVMWVKLPV 192
Cdd:cd06174    96 LGSGLIDPAVLaLIADLFPERERGRALGLLQAFGSVGGILGPLLGGILasSLGFGWRAVFLIAAALALLAAILLLLVVPD 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 193 ----ARKSHQLNILQIYGSLFSLAVHQPHLLRRGLAGGIGFGILALIFTTMTFILANEPYHFNDFQIGLFGIVGLAGVFA 268
Cdd:cd06174   176 ppesARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALG 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 269 TPWAGKKIAAGLENKIAVICMGLLMSAWIPLFFAQQSLVAYAVGVIMAYFGLSAFHVLNQNLVYRI-SAEARSRINSIYM 347
Cdd:cd06174   256 SLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELfPPEIRGTAFGLLN 335

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1752644444 348 TLYFGGAALGSFIAVYAWK-HWGWEACAILGLGLAMLSFLI 387
Cdd:cd06174   336 TFGFLGGAIGPLLAGFLLAaTFGLTGAFLVLAVLLLLAAIL 376
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
37-230 8.45e-07

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 50.68  E-value: 8.45e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  37 PLIYSIAEALKVNADQVALTIVISQLSYAVGLFILVPLGDFFEKRSYICLLMCCTGFAQVGLSLSQTLPALYGFTFLATF 116
Cdd:PRK11102   12 PALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 117 FSIATQVlvpfaaglaspkkspqVVGTLMSGLF-----------------LGILLARSIAGLLSTVWSWHAV-YLISGIV 178
Cdd:PRK11102   92 AAAAASV----------------VINALMRDMFpkeefsrmmsfvtlvmtIAPLLAPIIGGWLLVWFSWHAIfWVLALAA 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1752644444 179 ILVFAWVMWV---KLPVARKS--HQLNILQIYGSLFSlavhQPHLLRRGLAGGIGFG 230
Cdd:PRK11102  156 ILAAALVFFFipeTLPKERRQpfHLRTTIRNFASLFR----HKRVLGYMLASGFSFA 208
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
99-372 1.02e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 50.67  E-value: 1.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  99 SLSQTLPALYGFTFLATFFSIATQVLVPFAAGLA----SPKKSPQVVGTLMSGLFLGILLARSIAGLLSTVWS------W 168
Cdd:COG2211   103 DLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAeltpDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGgdaalgY 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 169 HAVYLISGIVILVFAWVMW--VKLPVARKSHQLNILQIYGSLFslavhQPHLLRRGLAGGIGFGILALIFTTMTFILANE 246
Cdd:COG2211   183 RLTALIFAVLGLLAFLLTFfgTKERPVPEEEKVSLKESLKALL-----KNRPFLLLLLAYLLFFLALALVAALLLYYFKY 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 247 PYHFNDFQIGLFG----IVGLAGVFATPWAGKKIAAGlenKIAVICMGLLMSAWIPLFFAQ-QSLVAYAVGVIMAYFGLS 321
Cdd:COG2211   258 VLGLSAALVGLLLalyfLAALLGAPLWPRLAKRFGKK---KAFIIGLLLAALGLLLLFFLGpGNLWLLLVLAALAGIGLG 334

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1752644444 322 AFHVLNQNLVYRISAEARSRINSIYMTLYFG--------GAALGSFIAVYAWKHWGWEA 372
Cdd:COG2211   335 AILVLPWAMLADVVDYDEWKTGRRREGLYFGiftfaiklGQALAGALAGLLLALFGYVA 393
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 42-322 3.64e-06

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 48.72  E-value: 3.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  42 IAEALKVNADQVALTIVISQLSYAVGLFILVPLGDFFEKRSYICLLMCCTGFAQVGLSLSQTLPALYGFTFL-----ATF 116
Cdd:cd17319    29 IMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLlgvaeAGF 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 117 FSIATQVLvpfaAGLASPKKSPQVVGTLMSGLFLGILLARSIAGLLSTVWSWHAVYLISGIVILVFAWVMWVKLPvarks 196
Cdd:cd17319   109 FPGAIKAL----AEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLR----- 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 197 hqlNILQIYgslfslavhqphllrrglAGGIGFGILALIFTTMTFILANEPYHFNDFQIGLF----GIVGLAGVFATPWA 272
Cdd:cd17319   180 ---QVWGLA------------------LGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLaaipFLAGAIGMILGGRL 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1752644444 273 GKKIAAGLENKIAVICMGLLMSAWIPLFFAQQSLVAyAVGVIMAYFGLSA 322
Cdd:cd17319   239 SDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVA-VILLSLAGFGIGA 287
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 65-191 8.12e-06

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 47.74  E-value: 8.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  65 AVGLFILVPLGDFFEKRsyICLLMCCTGFA--QVGLSLSQTLPALYGFTFLATF-FSIATQVLVPFAAGLASPKKSPQVV 141
Cdd:TIGR00895  66 AFGALFFGPLADRIGRR--RVLLWSILLFSvfTLLCALATNVTQLLILRFLAGLgLGGLMPNLNALVSEYAPKRFRGTAV 143

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1752644444 142 GTLMSGLFLGILLARSIAGLLSTVWSWHAVYLISGIVILVFAWVMWVKLP 191
Cdd:TIGR00895 144 GLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLP 193
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 65-387 1.41e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 46.82  E-value: 1.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  65 AVGLFILV---------PLGDFFEKRSYICLLMCCTGFAQVGLSLSQTLPALYGFTFLATF-FSIATQVLVPFAAGLASP 134
Cdd:cd17489    36 VVGLFTLAallarpfagRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIgWGAFTTAAATLVADIIPP 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 135 KKSPQVVGTLMSGLFLGILLARSIAGLLSTVWSWHAVYLISGIVILV---FAWVMWVKLPVARKSHQLNILQiygslfsl 211
Cdd:cd17489   116 SRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLallLVFLVKDPPPVAAEEAEAGTRA-------- 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 212 avHQPHLLRRGLAGGIGFGILALIFTTMTFILANEPYHFNDFQIGLFGIV-GLAGVFATPWAGKKIAAGLENKIAVICMG 290
Cdd:cd17489   188 --FRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGLFFTVyAIALLLSRPFSGKLSDRKGPKTVIIPGLL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 291 LLMSAWIPLFFAQQSLVAYAVGVIMAYFGLSAFHVLNQNLVYRISAEARSRINSIYMTLYFGGAALGSFIAVYAWKHWGW 370
Cdd:cd17489   266 LLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGY 345

                         330
                  ....*....|....*..
gi 1752644444 371 EACAILGLGLAMLSFLI 387
Cdd:cd17489   346 RAMFLLAAVVVLLALVL 362
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 41-268 1.81e-05

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 45.96  E-value: 1.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  41 SIAEALKVNADQVALTIVISQLSYAVGLFILVPLGDFFEKRSYICLLMCCTGFAQVGLSLSQTLPALYGFTFLATFF-SI 119
Cdd:COG0477    39 SIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGaGG 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 120 ATQVLVPFAAGLASPKKSPQVVGTLMSGLFLGILLARSIAGLLSTVWSWHAVYLISGIVILVFAWVMWVKLPVARKSHQL 199
Cdd:COG0477   119 LMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLAL 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1752644444 200 NILQIYGSLFSLAVHQPHLLRRGLAGGIGFGILALIFTTMTFILANEPYHFNDFQIGLFGIVGLAGVFA 268
Cdd:COG0477   199 LALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLL 267
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 37-361 2.01e-05

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 46.42  E-value: 2.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  37 PLIYSIAEALKVNADQVALTIVISQLSYAVGLFILVPLGDFFEKRSYICLLMCCTGFAQVGLSLSQTLPALYGFTFLATF 116
Cdd:cd17504    17 PALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGI 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 117 fSIAtqvLVPFAAGLA----SPKKSPQVVGTLMSGLFLGILLARSIAGLLSTVWSWHAVY-LISGIVILVFAWVMWVKLp 191
Cdd:cd17504    97 -GGA---VFPLAFALVreefPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFwTAAPVAVLLAALVPLIDL- 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 192 varksHQLNILQIYGSLFSLAVhqphllrrglaggIGFGILALIFTTMTFILANEPYHFN--DFQIGLFGI-VGLAGVFA 268
Cdd:cd17504   172 -----RLLRRRNVLLANITALL-------------AGFGMFMVFQLLPQLLQLPTPTGFGlgITEAGLLLLpGALVMLIA 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 269 TPWAGKKIAAGLENKIAVICMGLLMSAWIPLFFAQQSLVAYAVGVIMAYFGLS-AFHVLNQNLVYRISAEARSRINSIYM 347
Cdd:cd17504   234 GPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGlAFASLPNIVVESVPPDRTGIATGMNT 313

                         330
                  ....*....|....
gi 1752644444 348 TLYFGGAALGSFIA 361
Cdd:cd17504   314 VLRTIGSAIGPAIA 327
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 1-190 2.05e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 42.95  E-value: 2.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444   1 MEKIVEPNAENILSKSFIFIMAMTCGICAGSNYYNQPLI-YSIAEALKVNADQVALTIVISQLSYAVGLFILVPLGDFFE 79
Cdd:cd17325   184 SAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLpLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIG 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  80 KRSYICLLMCCTGFAQVGLSLSQTLPALYGFTFLA-TFFSIATQVLVPFAAGLASPKKSPQVVGTLMSGLFLGILLARSI 158
Cdd:cd17325   264 RKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLgLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLL 343

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1752644444 159 AGLLSTVWSWHAVYLISGIVILVFAWVMWVKL 190
Cdd:cd17325   344 GGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 41-323 6.14e-04

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 41.49  E-value: 6.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  41 SIAEALKVNADQVALTIVISQLSYAVGLFILVPLGDFFEKRSYICLLMCCTGFAQVGLSLSQTLPALYGFTFLATFFSIA 120
Cdd:cd17312    28 PIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSM 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 121 TqvLVPFAAGLA---SPKKSPQVVGTLMSGLFLGILLARSIAGLLSTVWSWHAVYLISGIVILVFAWVMWvklpvarksh 197
Cdd:cd17312   108 G--WPPCVKLLGnwfSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILF---------- 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 198 qlnilqiygslFSLAVHQPHLLRRGLAGGIGFGILALIFTTMTFILANEpYHFN----DFQIGLFGIVGLAGVFATPWAG 273
Cdd:cd17312   176 -----------FFLRDSPPYVWVLSLAYAFVYIVRYACLDWGPLYLYEV-KGYSlidaGWFSSLYEVGGIAGTILAGLLS 243

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1752644444 274 KKIAAGLENKIAVICMGLLMSAWIPLFFAQQSlvAYAVGVIMAYFGLSAF 323
Cdd:cd17312   244 DKLFGGRRAPIAVIYMLLMTLSLALFWFFPHN--KLLSIVLLFLIGFFVG 291
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 150-360 6.46e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 41.40  E-value: 6.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 150 LGILLARSIAGLLSTVwSWHAVYLISGIVILVFAWVMWVKLPVARKSHQLNIlqiYGSLFSLAVHQPHLLRRGLAGGIGF 229
Cdd:cd17473   135 LGGVVFLLLGGALAEI-GWRAPFLVYLLALPVLILVLLFLPEPARKSKSAAS---PGAATAAALPWKRVLPIYFLAFLAM 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 230 GILALIFTTMTFILANEpYHFNDFQIGLF-GIVGLAGVFATPWAGKKIAAGLENKIAVICMGLLMSAWIPLFFAQqSLVA 308
Cdd:cd17473   211 LLFYVIPIQLPFLLQER-GGGSAALIGLAlAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALAS-GLWV 288

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1752644444 309 YAVGVIMAYFGLS-AFHVLNQNLVYRISAEARSRINSIYMTLYFGGAALGSFI 360
Cdd:cd17473   289 VLLGAILAGLGFGlLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLV 341
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 68-386 6.80e-04

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 41.44  E-value: 6.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  68 LFILVPLG---DFFEKRSYICLL-MCCTGFAQVGLSLSQTLPALYGFTFLATFFSiATQVLVP-FAAGLASPKKSPQVVG 142
Cdd:cd17490    45 MLLRIPLGilsDRIGKRKLFIIIgLLFTVLASLIMILFPSPWGLLIARFLSGIAA-ATWVSFTvLYASYFPPDEAAKAMG 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 143 TLMSGLFLGILLARSIAGLLSTVWSWHAVYLIS-GIVILVFAWVMWVKLPVARKSHQLNILQIYGSLFSlavhQPHLLRR 221
Cdd:cd17490   124 LINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAaLAGVLGFILSLFIKEERREKKPVLTELKELLSVLK----DKKLLFF 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 222 GLAGGIGFGILALIFTTMTFILANEpYHFNDFQIGLFGIV-----GLAGVFATPWAGKKIaaGLENKI-------AVICM 289
Cdd:cd17490   200 SLLAILQQMITFSTTFGFTPLIAKQ-LGASSFQLGLLSIIyllpnALASLLSGTLFYKKL--GERNTIiigflllGAYCF 276

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 290 GLLMSAWIPLFFAQQSLVAYAVGVImayfglsaFHVLNQNLVYRISAEARSRINSIYMTLY----FGGAALGSFIAVYAW 365
Cdd:cd17490   277 LIPFAPNLTLLYLLQALNGFGTGIL--------FPLLMSLSIEGVPAEQRSTAMGFFQAIYalgmFLGPVLVGIISEAFG 348

                         330       340
                  ....*....|....*....|.
gi 1752644444 366 KHWGWEACAILGLGLAMLSFL 386
Cdd:cd17490   349 LQTGFFVIGVIALLAAILSLA 369
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 147-387 1.10e-03

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 40.66  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 147 GLFLGILLARSIAG--LLSTVWSWHAVYLISGIVILV-FAWVMWVKLPVARKSHQlnilQIYGSLFSLAVHQPHLLRRgl 223
Cdd:cd17472   125 GASIGIAFAISMVLgpLLAAHLGVSGLFLITAILSLVsLLILLFFVPDPPKIVQI----SEKEKKKLKKLLKNKRLLR-- 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 224 aggIGFGILALIFTTMTF-----ILANEPYHFNDFQIGLFGIVGLAGVFATPWAGKkIAAGLE--NKIAVICMGLLMSAW 296
Cdd:cd17472   199 ---LDFSIFILHFVLMAFfyilpLLLTQLGGGKGQLWKVYLPAILIGFILMVPFVI-YAEKKGkmKQVFVSSILLIAVGF 274

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 297 IPLFFAQQSLVAYAVGVIMAYFGLSAFHVLNQNLVYRIS-AEARSRINSIYMTLYFGGAALGSFIAVYAWKHWGWEACAI 375
Cdd:cd17472   275 LLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIApKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFL 354

                         250
                  ....*....|..
gi 1752644444 376 LGLGLAMLSFLI 387
Cdd:cd17472   355 TILILALLWLLV 366
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
42-195 1.13e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 40.62  E-value: 1.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  42 IAEALKVNADQVALTIVISQLSYAVGLFILVPLGDFFEKRSYICLL--MCCTGFAQVGLSLSQTLPALYGFTFLATFFSI 119
Cdd:COG2271   207 LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAigLLLAALALLLLALLPSPALAIALLFLAGFGLG 286

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1752644444 120 ATQVLVP-FAAGLASPKKSPQVVGTLMSGLFLGILLARSIAGLLSTVWSWHAVYLISGIVILVFAWVMWVKLPVARK 195
Cdd:COG2271   287 GAFGLLWaLAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 13-187 1.18e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 40.60  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  13 LSKSFIFIMAMTCGICAGsnYYNQPLIYSIAEALKVNADQVALTIVISQLSYAVGLFILVPLGDFFEKRSYICLLMCCTG 92
Cdd:cd17370   198 LPKAFWLYLLAVALFALG--NFSFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLA 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  93 FAQVGLSLSQTLPALY-GFTFLATFFSIATQVLVPFAAGLASPKKSPQVVGTLMSGLFLGILLARSIAGLLSTVWSWHAV 171
Cdd:cd17370   276 LAYLGFALGSSLWLLLlGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAA 355

                         170
                  ....*....|....*.
gi 1752644444 172 YLISGIVILVFAWVMW 187
Cdd:cd17370   356 FLFSAVLALIALLLLL 371
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 37-387 1.40e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 40.64  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  37 PLIYSIAEALKvNADQVALTIVISQLSYAVGLFILVP----LGDFFEKRSYICLLMCCTGFAQVGLSLSQTLPALYGFTF 112
Cdd:cd17330    17 PVLPFYVREFN-KLGASGYYVGLLQSSYSLGQFLASPlwgrLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARF 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 113 LATFFSIATQVLVPFAAGLASPKKSPQVVGTLMSGLFLGILLARSIAGLLSTVWSWHAVYLISGIVILVFAWVMWVKLPV 192
Cdd:cd17330    96 LDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLPP 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 193 ARKSHqlnilqIYGSLFSLAVhqphllrrglaggigfgilaLIFTTMTFILANEPYHFNDFQIG-LFGIVGLAGVFATPW 271
Cdd:cd17330   176 LRRLL------LVYFLIALAF--------------------AGLESVFSLFLKDRFGFSPSQIGlLLALVGIAGILAQLL 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 272 AGKKIAAGL-ENKIAVICMGLLMSAWIPLFFAQQSLVAYAVGVIMAYFGLSAFHVLNQNLVYRISAEARSRINSIYMTLY 350
Cdd:cd17330   230 LIPRLAKRLgERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQ 309

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1752644444 351 FGGAALGSFIAVYAWKHWGWEACAILGLGLAMLSFLI 387
Cdd:cd17330   310 SLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFL 346
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 41-364 2.19e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 39.85  E-value: 2.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  41 SIAEALKVNADQVALTIVISQLSYAVGLFILVPLGDFFEKRSYICLLMCCTGFAQVGLSLSQTLPALYGFTFLAtffSIA 120
Cdd:cd17321    21 TIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQ---GIG 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 121 TQVLVPFAAGLAS----PKKSPQVVGTLMSGLFLGILLARSIAGLLSTVWSWHAVYLISgIVILVFAWVMwvklpvarks 196
Cdd:cd17321    98 AAAIMPASLALIAatfpGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLIN-VPIGLVALLL---------- 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 197 hqlnilqiyGSLFSLAVhqphllrrgLAGGIGFGILALIFTTMTFILaNEPYHFNDFQIGLFGIVGLAGVFATPWAGKKI 276
Cdd:cd17321   167 ---------ARTFSGAV---------LAAFLLGAALGGLLFLLPLYL-QGVLGYSPLQAGLALLPLALAMLVAAPLAGRL 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 277 AAGLENKIaVICMGLLMSA----WIPLFFAQQSLVAYAVGVIMAYFGLSAFHVLNQNLVYRISAEARSRINS-IYMTLYF 351
Cdd:cd17321   228 ADRFGPRL-VLVAGLLLTAvgllLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASgILNTARQ 306

                         330
                  ....*....|...
gi 1752644444 352 GGAALGsfIAVYA 364
Cdd:cd17321   307 LGGALG--VALLG 317
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 19-247 3.15e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 39.23  E-value: 3.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  19 FIMAMTCGICAGSNyynQPLIYSIAEALKVNADQVALTIVISQLSYAVGLFILVPLGDFFEKRSYICLLMCCTGFAQVGL 98
Cdd:cd17333     2 YISFFSNGLTDALL---GILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  99 SLSQTLPALYGFTFLATFFSIATQVLVPFAAGLASPKKSPQVVGTLMSGLFLGILLARSIAG-LLSTVWSWHAVYLISGI 177
Cdd:cd17333    79 FATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATsLLTSELSWSWAYLIIGL 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1752644444 178 --VILVFAWVMWVKLPVARKSHQLNILQIYGSLFSLAVHQPHLLRRGLAGGIGFGILALIFTTMTFILANEP 247
Cdd:cd17333   159 iyLLLAILILLTLFPELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKK 230
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
15-204 4.16e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 39.12  E-value: 4.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  15 KSFIFIMAMTCGICAGSNYYNQPLIYSIAEALKVNADQVALTIVISQLSYAVGLFILVPLGDFFEKRSYICLLMCCTGFA 94
Cdd:COG2211   228 RPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  95 QVGLSLSQ--TLPALYGFTFLATFFSIATQVL----VPFAAGLASPKKSPQVVGTLMSGLFLGILLARSIAGLL------ 162
Cdd:COG2211   308 LLLLFFLGpgNLWLLLVLAALAGIGLGAILVLpwamLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALagllla 387

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1752644444 163 ------------STVWSWHAVYLISGIVILVFAWVMWVKLPVARKSHQLNILQI 204
Cdd:COG2211   388 lfgyvagaaqspSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAEL 441
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
37-360 6.36e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 38.30  E-value: 6.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  37 PLIYSIAEALKVNADQVALTIVISQLSYAVGLFILVPLGDFFEKRSYICLLMCCTGFAQVGLSLSQTLPALYGFTFLATF 116
Cdd:COG0738    29 PLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGL 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 117 FSIATQVLVPFAAGLASPKKSPQVVGTLMS----GLFLGILLArSIAGLLSTVWSWHAVYLISGIVILVFAWVMW-VKLP 191
Cdd:COG0738   109 GLGLLDVAANPYVAALGPETAASRLNLLHAffslGALLGPLLG-GLLILLGLSLSWHLPYLILAVLLLLLALLFLrSKLP 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 192 VARKSHQLNILQIYGSLFSLAvhQPHLLRRGLAGGIGFGILALIFTTMTfILANEPYHFNDFQIGLFGIVGLAGVFATPW 271
Cdd:COG0738   188 EIEEEEEEAAGSAASLKSLLK--NPRLLLGGLAIFLYVGAEGAIGDWLP-LYLKDVLGLSEATAALGLSLFWGGMTIGRF 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 272 AGKKIAAGLENKIAVICMGLLMSAWIPLFFAQQSLVAYAVGVIMAYFGLSAFHVLNQNLVYRISAEARSRINSIYMTLYF 351
Cdd:COG0738   265 LGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGI 344


                  ....*....
gi 1752644444 352 GGAALGSFI 360
Cdd:COG0738   345 VGGAIGPPL 353
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 98-386 9.69e-03

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 37.97  E-value: 9.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444  98 LSLSQTLPALYgFTFLATFFSIATQVLVPFAAGLASPKKSPQVVGTLMSGLFLGILLARSIAGLLSTVWSWHAVYLISGI 177
Cdd:cd17331    82 LAFASSVPMLF-LSRLPSVFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAV 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 178 VILVFAWVMWVKLPVARKSHQLN---------ILQIYGSLFSLAVHQ--PHLLRRGLAGGIGFGILALIFTtmtfILANE 246
Cdd:cd17331   161 GSLLSIVLVILLIPSNTKSKREKeakesasppSVFNLKEILRLLRLPgvAFLLLVKLLSGLPIGMFQSMFS----LVAMD 236

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752644444 247 PYHFNDFQIGLF----GIVGL-AGVFATPWAGKKiaaGLENKIAVICMGLLMSAWIPLFFAQQSLVAYAVGVIMAYFGLS 321
Cdd:cd17331   237 FFGLTPEENGYLmsyaGVLGMvVQGLLVGPLTKR---FGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSV 313

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1752644444 322 AFHVLNQNLVYRISAEARSRINSIYMTLYFGGAALGSFIAVYAWKHWGWEACAILGLGLAMLSFL 386
Cdd:cd17331   314 LYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTV 378
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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