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Conserved domains on  [gi|1752840421|gb|KAA9389529|]
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proline dehydrogenase [Staphylococcus epidermidis]

Protein Classification

bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase; bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase; proline dehydrogenase family protein; proline dehydrogenase family protein( domain architecture ID 11423475)

bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase catalyzes the two-step oxidation of proline to glutamate; bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase catalyzes the two-step oxidation of proline to glutamate; proline dehydrogenase family protein similar to Pectobacterium carotovorum carbapenem antibiotics biosynthesis protein CarD; proline dehydrogenase family protein similar to Pectobacterium carotovorum carbapenem antibiotics biosynthesis protein CarD; proline dehydrogenase family protein similar to Pectobacterium carotovorum carbapenem antibiotics biosynthesis protein CarD; proline dehydrogenase family protein similar to human mitochondrial proline dehydrogenase 1 that converts proline to delta-1-pyrroline-5-carboxylate; proline dehydrogenase family protein similar to Pectobacterium carotovorum carbapenem antibiotics biosynthesis protein CarD; proline dehydrogenase family protein similar to human mitochondrial proline dehydrogenase 1 that converts proline to delta-1-pyrroline-5-carboxylate; proline dehydrogenase family protein similar to human mitochondrial proline dehydrogenase 1 that converts proline to delta-1-pyrroline-5-carboxylate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PutA super family cl33919
Proline dehydrogenase [Amino acid transport and metabolism]; Proline dehydrogenase is part of ...
 20-276 4.63e-55

Proline dehydrogenase [Amino acid transport and metabolism]; Proline dehydrogenase is part of the Pathway/BioSystem: Proline degradation


The actual alignment was detected with superfamily member COG0506:

Pssm-ID: 440272 [Multi-domain]  Cd Length: 975  Bit Score: 193.34  E-value: 4.63e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752840421  20 IAKKMGPQM--GANRVVAGNTIHQLIETIQYLNDYNISVTVDSLGEFVSTREESIKAKEEILEIIDAIYNNNVK-AHMSV 96
Cdd:COG0506   101 IRPAVRRAMrrMARRFVAGETIEEALKAARKLRAKGYRVSLDLLGEAVLTEAEAERYLDAYLEALEAIGAAGVDrPGVSV 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752840421  97 KISQLGSEFD-------LNLAYENMREILLKADKNGKmHINIDTEKYDSLSKIQHIIDRLKGE-----FKNVGTVIQAYL 164
Cdd:COG0506   181 KLSALGPRYSpaqrervVEELLERLRPLARAAREAGI-FVTIDMEEYDRLDLTLDVFERLLADpelagWPGVGIVLQAYL 259

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752840421 165 YEA----DDLIDKYPE----LRLRLVKGAYKE----DASI------AYQSKEEIDANYIRIIKKRLLNSKN-FTSVATHD 225
Cdd:COG0506   260 KRAeadlDRLAALARRggrrIRVRLVKGAYWDpeivRAQVhgwpypVFTRKADTDANYLRCARKLLEAGDAiYPQFATHN 339

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1752840421 226 NEIINQVKQFMKENHISKDKMEFQMLYGFRTELAQKIANE-GYLFTVYVPYG 276
Cdd:COG0506   340 ARTIAAALALAGERGRPPDRFEFQMLYGMGEDLQRALAAVdGGRLLLYCPVV 391
 
Name Accession Description Interval E-value
PutA COG0506
Proline dehydrogenase [Amino acid transport and metabolism]; Proline dehydrogenase is part of ...
 20-276 4.63e-55

Proline dehydrogenase [Amino acid transport and metabolism]; Proline dehydrogenase is part of the Pathway/BioSystem: Proline degradation


Pssm-ID: 440272 [Multi-domain]  Cd Length: 975  Bit Score: 193.34  E-value: 4.63e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752840421  20 IAKKMGPQM--GANRVVAGNTIHQLIETIQYLNDYNISVTVDSLGEFVSTREESIKAKEEILEIIDAIYNNNVK-AHMSV 96
Cdd:COG0506   101 IRPAVRRAMrrMARRFVAGETIEEALKAARKLRAKGYRVSLDLLGEAVLTEAEAERYLDAYLEALEAIGAAGVDrPGVSV 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752840421  97 KISQLGSEFD-------LNLAYENMREILLKADKNGKmHINIDTEKYDSLSKIQHIIDRLKGE-----FKNVGTVIQAYL 164
Cdd:COG0506   181 KLSALGPRYSpaqrervVEELLERLRPLARAAREAGI-FVTIDMEEYDRLDLTLDVFERLLADpelagWPGVGIVLQAYL 259

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752840421 165 YEA----DDLIDKYPE----LRLRLVKGAYKE----DASI------AYQSKEEIDANYIRIIKKRLLNSKN-FTSVATHD 225
Cdd:COG0506   260 KRAeadlDRLAALARRggrrIRVRLVKGAYWDpeivRAQVhgwpypVFTRKADTDANYLRCARKLLEAGDAiYPQFATHN 339

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1752840421 226 NEIINQVKQFMKENHISKDKMEFQMLYGFRTELAQKIANE-GYLFTVYVPYG 276
Cdd:COG0506   340 ARTIAAALALAGERGRPPDRFEFQMLYGMGEDLQRALAAVdGGRLLLYCPVV 391
Pro_dh pfam01619
Proline dehydrogenase;
42-289 1.25e-37

Proline dehydrogenase;


Pssm-ID: 426348 [Multi-domain]  Cd Length: 296  Bit Score: 136.08  E-value: 1.25e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752840421  42 LIETIQYLNDYNISVTVDSLGEFVSTREESIKAKEEILEIIDAI------YNNNVKAHMSVKISQLGSEFD-------LN 108
Cdd:pfam01619   1 ALKTIEKLRKQGYRFSLDMLGEAALTEADADRYLDAYLRAIDALgkaagpWPLGPRPGISVKLSALHPRYEplerervMA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752840421 109 LAYENMREILLKADKNGkMHINIDTEKYDSLSKIQHIIDRL--KGEFKN---VGTVIQAYLYEADDLIDK---------Y 174
Cdd:pfam01619  81 ELLERLRPLCRLAKELG-VRLNIDAEEADRLDLTLDLFERLlaEPELRGwngVGITLQAYLKDALAVLDWllelarrrgR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752840421 175 PeLRLRLVKGAY----------KEDASIAYQSKEEIDANYIRIIKKRLLNSKNFTS-VATHDNEIINQVKQFMKENHISK 243
Cdd:pfam01619 160 P-LGVRLVKGAYwdseikraqqGGWPYPVFTRKEATDANYEACARFLLENHDRIYPqFATHNARSVAAALALAEELGIPP 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1752840421 244 DKMEFQMLYGFRTELAQKIANEGYLFTVYVPYG--NDWFAYFMRRLAE 289
Cdd:pfam01619 239 RRFEFQQLYGMGDNLSFALVAAGYRVRKYAPVGphEELLAYLVRRLLE 286
PLN02681 PLN02681
proline dehydrogenase
 104-290 1.07e-07

proline dehydrogenase


Pssm-ID: 215366 [Multi-domain]  Cd Length: 455  Bit Score: 53.17  E-value: 1.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752840421 104 EFDLNLAYENMREILLKADKNGkMHINIDTEKYDSLSKIQHIIDRLKGEF---KNVGTV---IQAYLYEADDlidkypEL 177
Cdd:PLN02681  212 ERLLELAHERLQKLCERAAQLG-VPLLIDAEYTSLQPAIDYITYDLAREFnkgKDRPIVygtYQAYLKDARE------RL 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752840421 178 RL--------------RLVKGAY----KEDASIA------YQSKEEIDANYIR---IIKKRLLNSKNFTSVATHDNEIIN 230
Cdd:PLN02681  285 RLdlerseregvplgaKLVRGAYlsleRRLAASLgvpspvHDTIQDTHACYNRcaeFLLEKASNGDGEVMLATHNVESGE 364

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1752840421 231 QVKQFMKENHISK--DKMEFQMLYGFRTELAQKIANEGYLFTVYVPYG--NDWFAYFMRRLAER 290
Cdd:PLN02681  365 LAAAKMNELGLHKgdPRVQFAQLLGMSDNLSFGLGNAGFRVSKYLPYGpvEEVIPYLLRRAEEN 428
 
Name Accession Description Interval E-value
PutA COG0506
Proline dehydrogenase [Amino acid transport and metabolism]; Proline dehydrogenase is part of ...
 20-276 4.63e-55

Proline dehydrogenase [Amino acid transport and metabolism]; Proline dehydrogenase is part of the Pathway/BioSystem: Proline degradation


Pssm-ID: 440272 [Multi-domain]  Cd Length: 975  Bit Score: 193.34  E-value: 4.63e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752840421  20 IAKKMGPQM--GANRVVAGNTIHQLIETIQYLNDYNISVTVDSLGEFVSTREESIKAKEEILEIIDAIYNNNVK-AHMSV 96
Cdd:COG0506   101 IRPAVRRAMrrMARRFVAGETIEEALKAARKLRAKGYRVSLDLLGEAVLTEAEAERYLDAYLEALEAIGAAGVDrPGVSV 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752840421  97 KISQLGSEFD-------LNLAYENMREILLKADKNGKmHINIDTEKYDSLSKIQHIIDRLKGE-----FKNVGTVIQAYL 164
Cdd:COG0506   181 KLSALGPRYSpaqrervVEELLERLRPLARAAREAGI-FVTIDMEEYDRLDLTLDVFERLLADpelagWPGVGIVLQAYL 259

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752840421 165 YEA----DDLIDKYPE----LRLRLVKGAYKE----DASI------AYQSKEEIDANYIRIIKKRLLNSKN-FTSVATHD 225
Cdd:COG0506   260 KRAeadlDRLAALARRggrrIRVRLVKGAYWDpeivRAQVhgwpypVFTRKADTDANYLRCARKLLEAGDAiYPQFATHN 339

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1752840421 226 NEIINQVKQFMKENHISKDKMEFQMLYGFRTELAQKIANE-GYLFTVYVPYG 276
Cdd:COG0506   340 ARTIAAALALAGERGRPPDRFEFQMLYGMGEDLQRALAAVdGGRLLLYCPVV 391
Pro_dh pfam01619
Proline dehydrogenase;
42-289 1.25e-37

Proline dehydrogenase;


Pssm-ID: 426348 [Multi-domain]  Cd Length: 296  Bit Score: 136.08  E-value: 1.25e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752840421  42 LIETIQYLNDYNISVTVDSLGEFVSTREESIKAKEEILEIIDAI------YNNNVKAHMSVKISQLGSEFD-------LN 108
Cdd:pfam01619   1 ALKTIEKLRKQGYRFSLDMLGEAALTEADADRYLDAYLRAIDALgkaagpWPLGPRPGISVKLSALHPRYEplerervMA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752840421 109 LAYENMREILLKADKNGkMHINIDTEKYDSLSKIQHIIDRL--KGEFKN---VGTVIQAYLYEADDLIDK---------Y 174
Cdd:pfam01619  81 ELLERLRPLCRLAKELG-VRLNIDAEEADRLDLTLDLFERLlaEPELRGwngVGITLQAYLKDALAVLDWllelarrrgR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752840421 175 PeLRLRLVKGAY----------KEDASIAYQSKEEIDANYIRIIKKRLLNSKNFTS-VATHDNEIINQVKQFMKENHISK 243
Cdd:pfam01619 160 P-LGVRLVKGAYwdseikraqqGGWPYPVFTRKEATDANYEACARFLLENHDRIYPqFATHNARSVAAALALAEELGIPP 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1752840421 244 DKMEFQMLYGFRTELAQKIANEGYLFTVYVPYG--NDWFAYFMRRLAE 289
Cdd:pfam01619 239 RRFEFQQLYGMGDNLSFALVAAGYRVRKYAPVGphEELLAYLVRRLLE 286
PLN02681 PLN02681
proline dehydrogenase
 104-290 1.07e-07

proline dehydrogenase


Pssm-ID: 215366 [Multi-domain]  Cd Length: 455  Bit Score: 53.17  E-value: 1.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752840421 104 EFDLNLAYENMREILLKADKNGkMHINIDTEKYDSLSKIQHIIDRLKGEF---KNVGTV---IQAYLYEADDlidkypEL 177
Cdd:PLN02681  212 ERLLELAHERLQKLCERAAQLG-VPLLIDAEYTSLQPAIDYITYDLAREFnkgKDRPIVygtYQAYLKDARE------RL 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752840421 178 RL--------------RLVKGAY----KEDASIA------YQSKEEIDANYIR---IIKKRLLNSKNFTSVATHDNEIIN 230
Cdd:PLN02681  285 RLdlerseregvplgaKLVRGAYlsleRRLAASLgvpspvHDTIQDTHACYNRcaeFLLEKASNGDGEVMLATHNVESGE 364

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1752840421 231 QVKQFMKENHISK--DKMEFQMLYGFRTELAQKIANEGYLFTVYVPYG--NDWFAYFMRRLAER 290
Cdd:PLN02681  365 LAAAKMNELGLHKgdPRVQFAQLLGMSDNLSFGLGNAGFRVSKYLPYGpvEEVIPYLLRRAEEN 428
putA PRK11809
trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate ...
 129-295 5.55e-06

trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed


Pssm-ID: 236989 [Multi-domain]  Cd Length: 1318  Bit Score: 48.05  E-value: 5.55e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752840421  129 INIDTEKYDSLSKIQHIIDRLKGE-----FKNVGTVIQAYL----YEADDLID--KYPELRL--RLVKGAYkEDASI--- 192
Cdd:PRK11809   367 INIDAEEADRLEISLDLLEKLCFEpelagWNGIGFVIQAYQkrcpFVIDYLIDlaRRSRRRLmiRLVKGAY-WDSEIkra 445

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752840421  193 ---------AYQSKEEIDANYIRIIKKrLLNSKN--FTSVATHDNEIINQVKQFMKENHISkDKMEFQMLYGFRTELAQK 261
Cdd:PRK11809   446 qvdglegypVYTRKVYTDVSYLACARK-LLAVPNliYPQFATHNAHTLAAIYHLAGQNYYP-GQYEFQCLHGMGEPLYEQ 523

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1752840421  262 I---ANEGYL---FTVYVPYGN--DWFAYFMRRLAERPQNLS 295
Cdd:PRK11809   524 VvgkVADGKLnrpCRIYAPVGTheTLLAYLVRRLLENGANTS 565
PRK11905 PRK11905
bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed
 127-289 2.31e-04

bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed


Pssm-ID: 237018 [Multi-domain]  Cd Length: 1208  Bit Score: 42.93  E-value: 2.31e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752840421  127 MHINIDTEKYD----SLSKIQHII--DRLKGeFKNVGTVIQAY----LYEADDLIDKYPEL--RL--RLVKGAYkEDASI 192
Cdd:PRK11905   285 IGLNIDAEEADrlelSLDLLEALCsdPDLAG-WNGIGFVVQAYqkrcPFVIDYLIDLARRSgrRLmvRLVKGAY-WDAEI 362

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752840421  193 ------------AYQSKEEIDANYIRIIKKrLLNSKN--FTSVATHDNEIINQVKQFMKEnhisKDKMEFQMLYGFRTEL 258
Cdd:PRK11905   363 kraqvdglegfpVFTRKVHTDVSYIACARK-LLAARDviYPQFATHNAQTLAAIYELAGG----KGDFEFQCLHGMGEPL 437

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1752840421  259 AQKIANEGYLFT---VYVPYGN--DWFAYFMRRLAE 289
Cdd:PRK11905   438 YDQVVGKEKLGRpcrIYAPVGTheTLLAYLVRRLLE 473
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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