|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
1-894 |
0e+00 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 1887.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 1 MTEEPMRPDPDRLLIQTQGRTRGKLKIFFGACAGVGKTYAMLQEAQRLRAQGLDILVGVVETHGRQETAALLEGLAIQPL 80
Cdd:PRK10490 1 MNNEPLRPDPDRLLEQTAEPHRGKLKIFFGACAGVGKTYAMLQEAQRLRAQGLDVLVGVVETHGRKETAALLEGLTVLPP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 81 KRIHHRGRVVQEFDLDAALARNPALILMDELAHSNAPGSRHPKRWQDVDELLDAGIDVFTTVNVQHLESLNDVVGGVTGI 160
Cdd:PRK10490 81 KRIHHRGRHISEFDLDAALARRPALILMDELAHSNAPGSRHPKRWQDVEELLEAGIDVFTTVNVQHLESLNDVVGGVTGI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 161 QVRETVPDPIFDAADEIVLVDLPPDDLRQRLHEGKVYIAGQAERAIEHFFRKGNLIALRELALRRTADRVDDQMRAWRDR 240
Cdd:PRK10490 161 QVRETVPDPFFDAADEVVLVDLPPDDLRQRLNEGKVYIAGQAERAIEHFFRKGNLIALRELALRRTADRVDDQMRAWRDH 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 241 QGQEKVWHTRDAILLCIGQGAGNEKLVRTAARLAARLGSVWHAVYVETPRLHQLPETSRRAILSALHLAQELGAETATLA 320
Cdd:PRK10490 241 QGEEKVWHTRDAILLCIGHNTGSEKLVRTAARLAARLGSVWHAVYVETPRLHRLPEKKRRAILSALRLAQELGAETATLS 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 321 DPVEEKAVLRYAREHNLGKIVIGRRNKRRWWSQDTFAERLARHAPDLDLLIVALDDKPTPATAKAADNRPFIEKWRVQLR 400
Cdd:PRK10490 321 DPAEEKAVLRYAREHNLGKIIIGRRASRRWWRRESFADRLARLGPDLDLVIVALDEPPARAIAKAPDSRPFKEKWRVQIQ 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 401 GCAVAVALCALITLVAHQWLIAFDAANLVMVYLLGVVLVALFYGRWPSVVATIINVVSFDLFFIAPRGTLAVSDVQYLLT 480
Cdd:PRK10490 401 GCLVAIALCALITLIAMQWLPAFDAANLVMLYLLGVVVVALFYGRWPSVVATVINVASFDLFFVAPRGTLAVSDVQYLLT 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 481 FAVMLSVGLIIGNLTAGVRYQARIARYREQRTRHLYEMSKALAVGRSARDIAATSQQFIASTFHARGLLLLPDEHGKLQA 560
Cdd:PRK10490 481 FAVMLTVGLVIGNLTAGVRYQARVARYREQRTRHLYEMSKALAVGLSPEDIAATSEHFLASTFQARSQLLLPDDNGKLQP 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 561 PQPLAEITPWDEAIARWSFDKGLPAGAGTDTLPGVPYQILPLRTAGKTLGLVIVEPGNLRQLMIPEQQRLLETFTLLVAS 640
Cdd:PRK10490 561 LTHDQGMTPWDDAIARWSFDKGQPAGAGTDTLPGVPYQILPLKSAQKTYGLLAVEPGNLRQLMIPEQQRLLETFTLLIAN 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 641 ALERLFLTESEEQARLASEREQLRNSLLAALSHDLRTPLTVLFGQAEILTLDLAAEGSNHAPQASEIRQHVLNTTRLVNN 720
Cdd:PRK10490 641 ALERLTLTASEEQARLASEREQLRNALLAALSHDLRTPLTVLFGQAEILTLDLASEGSPHARQASEIRQQVLNTTRLVNN 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 721 LLDMARIQSGGFNLRKEWLTVEEVVGSALKMLEPGLGGRHIDLSLSDPLTLIHVDGPLFERVLINLLENAAKYAGPRAQT 800
Cdd:PRK10490 721 LLDMARIQSGGFNLRKEWLTLEEVVGSALQMLEPGLSGHPINLSLPEPLTLIHVDGPLFERVLINLLENAVKYAGAQAEI 800
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 801 GVRTSWRDDRLDLEVWDNGPGIPAGQEQAIFAKFARGNKESAIPGVGLGLAICQAIVEVHGGEIYARNRPEGGASFHVLL 880
Cdd:PRK10490 801 GIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESAIPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTL 880
|
890
....*....|....*
gi 1755387238 881 PKETPPELD-IHEVM 894
Cdd:PRK10490 881 PLETPPELEeFHEDM 895
|
|
| KdpD |
pfam02702 |
Osmosensitive K+ channel His kinase sensor domain; This is a family of KdpD sensor kinase ... |
21-230 |
1.57e-138 |
|
Osmosensitive K+ channel His kinase sensor domain; This is a family of KdpD sensor kinase proteins that regulate the kdpFABC operon responsible for potassium transport. The aligned region corresponds to the N-terminal cytoplasmic part of the protein which functions as the sensor domain responsible for sensing turgor pressure. It recognizes C-di-AMP and K+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 460656 [Multi-domain] Cd Length: 210 Bit Score: 410.65 E-value: 1.57e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 21 TRGKLKIFFGACAGVGKTYAMLQEAQRLRAQGLDILVGVVETHGRQETAALLEGLAIQPLKRIHHRGRVVQEFDLDAALA 100
Cdd:pfam02702 1 RRGRLKIFLGAAPGVGKTYAMLQEAHRLKKRGVDVVIGYVETHGRPETEALLEGLEVIPRREIEYRGRTLEEMDLDAILA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 101 RNPALILMDELAHSNAPGSRHPKRWQDVDELLDAGIDVFTTVNVQHLESLNDVVGGVTGIQVRETVPDPIFDAADEIVLV 180
Cdd:pfam02702 81 RRPEVVLVDELAHTNAPGSRHPKRWQDVEELLDAGIDVYTTVNIQHLESLNDVVEQITGVRVRETVPDSVLDRADEVELV 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1755387238 181 DLPPDDLRQRLHEGKVYIAGQAERAIEHFFRKGNLIALRELALRRTADRV 230
Cdd:pfam02702 161 DLTPEELLERLKEGKVYPPEKAERALKNFFRKGNLTALRELALRRVADRV 210
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
651-885 |
4.53e-72 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 237.11 E-value: 4.53e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 651 EEQARLASEREQLRNSLLAALSHDLRTPLTVLFGQAEILTLDLAAEGSNHAPQASEIRQHVLNTTRLVNNLLDMARIQSG 730
Cdd:COG2205 3 EEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 731 GFNLRKEWLTVEEVVGSALKMLEPGLGGRHIDLSLS--DPLTLIHVDGPLFERVLINLLENAAKYAGPRAQTGVRTSWRD 808
Cdd:COG2205 83 KLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDlpPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREG 162
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1755387238 809 DRLDLEVWDNGPGIPAGQEQAIFAKFARGNKESAIPGVGLGLAICQAIVEVHGGEIYARNRPEGGASFHVLLPKETP 885
Cdd:COG2205 163 DGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAES 239
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
592-883 |
1.27e-54 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 192.43 E-value: 1.27e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 592 LPGVPYQILPLRTAGKTLGLVIVEPGNLRQLMIPEQQRLLETFTLLVASALERLFLTESEEQARLASEREQLRNSLLAAL 671
Cdd:COG0642 38 LALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANV 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 672 SHDLRTPLTVLFGQAEILTLDLAAEgsnHAPQASEIRQHVLNTTRLVNNLLDMARIQSGGFNLRKEWLTVEEVVGSALKM 751
Cdd:COG0642 118 SHELRTPLTAIRGYLELLLEELDEE---QREYLETILRSADRLLRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVEL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 752 LEPGLGGRHIDLSL--SDPLTLIHVDGPLFERVLINLLENAAKYAGPRAQTGVRTSWRDDRLDLEVWDNGPGIPAGQEQA 829
Cdd:COG0642 195 FRPLAEEKGIELELdlPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLER 274
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1755387238 830 IFAKFARGNKESAIPGVGLGLAICQAIVEVHGGEIYARNRPEGGASFHVLLPKE 883
Cdd:COG0642 275 IFEPFFRTDPSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPLA 328
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
502-885 |
7.53e-54 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 192.46 E-value: 7.53e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 502 ARIARYREQRTRHLYEMSKALAVGRSARDIAATSQQFIASTFHARGLLLLPDEHGKLQAPQPLAEITPWDEAIARWSFDK 581
Cdd:COG5002 10 ALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 582 GLPAGAGTDTLPGVPYQILPLRTAGKTLGLVIVEPGNLRQLMIPEQQRLLETFTLLVASALERLFLTESEEQarlaserE 661
Cdd:COG5002 90 LLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERL-------E 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 662 QLRNSLLAALSHDLRTPLTVLFGQAEILtldlaaegSNHAPQASEIRQHVLNT--------TRLVNNLLDMARIQSGGFN 733
Cdd:COG5002 163 QMRREFVANVSHELRTPLTSIRGYLELL--------LDGAADDPEERREYLEIileeaerlSRLVNDLLDLSRLESGELK 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 734 LRKEWLTVEEVVGSALKMLEPGLGGRHIDLSLS--DPLTLIHVDGPLFERVLINLLENAAKYAGPRAQTGVRTSWRDDRL 811
Cdd:COG5002 235 LEKEPVDLAELLEEVVEELRPLAEEKGIELELDlpEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQV 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1755387238 812 DLEVWDNGPGIPAGQEQAIFAKFARGNKE--SAIPGVGLGLAICQAIVEVHGGEIYARNRPEGGASFHVLLPKETP 885
Cdd:COG5002 315 RISVRDTGIGIPEEDLPRIFERFYRVDKSrsRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
410-883 |
2.95e-40 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 156.10 E-value: 2.95e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 410 ALITLVAHQWLIAFDAANLVMVYLLGVVLVALFYGRWPSVVATIINVVSFDLFFIAPRGTLAVSDVQYLLTFAVMLSVGL 489
Cdd:COG4251 18 LLLLLLLLLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 490 IIGNLTAGVRYQARIARYREQRTRHLYEMSKALAVGRSARDIAATSQQFIASTFHARGLLLLPDEHGKLQAPQPLAEITP 569
Cdd:COG4251 98 LVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAE 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 570 WDEAIARWSFDKGLPAGAGTDTLPGVPYQILPLRTAGKTLGLVIVEPGNLRQLMIPEQQRLLETFTLLVASALERLFLTE 649
Cdd:COG4251 178 LELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLEL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 650 SEEQARLASEREQLRNSLLAA----------LSHDLRTPLTVLFGQAEILTLDLAAEGSNHAPQASE-IRQHVLNTTRLV 718
Cdd:COG4251 258 RLELEELEEELEERTAELERSneeleqfayvASHDLREPLRKISGFSQLLEEDYGDKLDEEGREYLErIRDAAERMQALI 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 719 NNLLDMARIQSGGfnLRKEWLTVEEVVGSALKMLEPGLGGRHIDLSLsDPLTLIHVDGPLFERVLINLLENAAKYAGPRA 798
Cdd:COG4251 338 DDLLAYSRVGRQE--LEFEPVDLNELLEEVLEDLEPRIEERGAEIEV-GPLPTVRGDPTLLRQVFQNLISNAIKYSRPGE 414
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 799 QT--GVRTSWRDDRLDLEVWDNGPGIPAGQEQAIFAKFARGNKESAIPGVGLGLAICQAIVEVHGGEIYARNRPEGGASF 876
Cdd:COG4251 415 PPriEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATF 494
|
....*..
gi 1755387238 877 HVLLPKE 883
Cdd:COG4251 495 YFTLPKA 501
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
621-887 |
1.19e-37 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 146.65 E-value: 1.19e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 621 QLMIPEQQRLLETFTLLVASALERLF--LTESEEQARLASEREqlrnsLLAALSHDLRTPLTVLFGQAEILTLDLAAEGS 698
Cdd:COG5000 161 ELTRDGRRTLLVRASPLRDDGYVIVFddITELLRAERLAAWGE-----LARRIAHEIKNPLTPIQLSAERLRRKLADKLE 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 699 NHAPQASE----IRQHVLNTTRLVNNLLDMARIQSggfnLRKEWLTVEEVVGSALKMLEPGLGGRHIDL--SLSDPLTLI 772
Cdd:COG5000 236 EDREDLERaldtIIRQVDRLKRIVDEFLDFARLPE----PQLEPVDLNELLREVLALYEPALKEKDIRLelDLDPDLPEV 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 773 HVDGPLFERVLINLLENAAKYAGPRAQTGVRTSWRDDRLDLEVWDNGPGIPAGQEQAIFakfargnkesaIP-------G 845
Cdd:COG5000 312 LADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIF-----------EPffttkpkG 380
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1755387238 846 VGLGLAICQAIVEVHGGEIYARNRPEGGASFHVLLPKETPPE 887
Cdd:COG5000 381 TGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAEEAE 422
|
|
| DUF4118 |
pfam13493 |
Domain of unknown function (DUF4118); This domain is found in a wide variety of bacterial ... |
403-508 |
1.46e-37 |
|
Domain of unknown function (DUF4118); This domain is found in a wide variety of bacterial signalling proteins. It is likely to be a transmembrane domain involved in ligand sensing.
Pssm-ID: 463897 Cd Length: 107 Bit Score: 136.05 E-value: 1.46e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 403 AVAVALCALITLVAHQWLIAFDAANLVMVYLLGVVLVALFYGRWPSVVATIINVVSFDLFFIAPRGTLAVSDVQYLLTFA 482
Cdd:pfam13493 2 LLAVLILALATLLALLLRPLLPLANIALLFLLAVLLVALRGGRGPGLLAAVLSVLLFNYFFTPPYFTFTVSDPGYLLTLV 81
|
90 100
....*....|....*....|....*.
gi 1755387238 483 VMLSVGLIIGNLTAGVRYQARIARYR 508
Cdd:pfam13493 82 VFLLVALLTSTLTARLRRQARQARRR 107
|
|
| USP_KdpD-like |
cd01987 |
USP domain of the osmosensitive K+ channel histidine kinase family; The KdpDE two component ... |
253-373 |
1.68e-37 |
|
USP domain of the osmosensitive K+ channel histidine kinase family; The KdpDE two component system is widespread in bacteria and archaea; it controls potassium homeostasis and virulence by regulating the transcription of multiple genes, including a kdpFABC operon, which encodes a high-affinity P-type ATPase transporter. The KdpD histidine kinase (HK, EC:2.7.13.3) contain an N-terminal sensory cytoplasmic region (NTR) composed of KdpD' and universal stress protein (USP) domains, a canonical transmembrane domain, and a cytoplasmic C-terminal region with a transmitter GAF domain and an EnvZ-like catalytic HK domain. Proteins containing the USP domain are induced by many environmental stressors such as nutrient starvation, drought, extreme temperatures, high salinity, and the presence of uncouplers, antibiotics, and metals. It enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.
Pssm-ID: 467491 [Multi-domain] Cd Length: 124 Bit Score: 136.61 E-value: 1.68e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 253 ILLCIGQGAGNEKLVRTAARLAARLGSVWHAVYVETPRLHQLPETSRRAILSALHLAQELGAETATLADPVEEKAVLRYA 332
Cdd:cd01987 2 ILVCISSSPTSEKLIRRAARLAERLNGELTAVYVETPEESRLDEESQRRLLTNLKLAEELGAEVVSVEGDDVAEAIVEFA 81
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1755387238 333 REHNLGKIVIGR--RNKRRWWSQDTFAERLARHAPDLDLLIVA 373
Cdd:cd01987 82 RERNVTQIVLGQsrRRRWRRLFKGSLVDRLLREAPNIDVHIVP 124
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
539-881 |
3.20e-37 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 143.79 E-value: 3.20e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 539 IASTFHARGLLLLPDEHGKLQAPQPLAEITPWDEAIARWSFDKGLPAGAGTDTLPGVPYQILPLRTAGKTLGLVIVEPGN 618
Cdd:COG4191 9 LLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 619 LRQLMIPEQQRLLETFTLLVASALERLFLTESEEQARLASEREQLRNS--------LLAALSHDLRTPLTVLFGQAEILT 690
Cdd:COG4191 89 LLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQSeklaalgeLAAGIAHEINNPLAAILGNAELLR 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 691 LDLAAEGSNH-APQA-SEIRQHVLNTTRLVNNLLDMARIQSggfnLRKEWLTVEEVVGSALKMLEPGLGGRHIDLS--LS 766
Cdd:COG4191 169 RRLEDEPDPEeLREAlERILEGAERAAEIVRSLRAFSRRDE----EEREPVDLNELIDEALELLRPRLKARGIEVEldLP 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 767 DPLTLIHVDGPLFERVLINLLENAAkYAGPRAQTG---VRTSWRDDRLDLEVWDNGPGIPAGQEQAIFAKF----ARGNk 839
Cdd:COG4191 245 PDLPPVLGDPGQLEQVLLNLLINAI-DAMEEGEGGritISTRREGDYVVISVRDNGPGIPPEVLERIFEPFfttkPVGK- 322
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1755387238 840 esaipGVGLGLAICQAIVEVHGGEIYARNRPEGGASFHVLLP 881
Cdd:COG4191 323 -----GTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
779-880 |
4.35e-31 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 117.32 E-value: 4.35e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 779 FERVLINLLENAAKYAGPRAQTGVRTSWRDDRLDLEVWDNGPGIPAGQEQAIFAKFARGNKESAIPGVGLGLAICQAIVE 858
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGGGTGLGLAIVRRIVE 80
|
90 100
....*....|....*....|..
gi 1755387238 859 VHGGEIYARNRPEGGASFHVLL 880
Cdd:cd00075 81 AHGGRITVESEPGGGTTFTVTL 102
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
775-883 |
8.97e-30 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 113.90 E-value: 8.97e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 775 DGPLFERVLINLLENAAKYAGPRAQTGVRTSWRDDRLDLEVWDNGPGIPAGQEQAIFAKFARG-NKESAIPGVGLGLAIC 853
Cdd:smart00387 2 DPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTdKRSRKIGGTGLGLSIV 81
|
90 100 110
....*....|....*....|....*....|
gi 1755387238 854 QAIVEVHGGEIYARNRPEGGASFHVLLPKE 883
Cdd:smart00387 82 KKLVELHGGEISVESEPGGGTTFTITLPLE 111
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
775-884 |
7.10e-27 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 105.53 E-value: 7.10e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 775 DGPLFERVLINLLENAAKYAGPRAQTGVRTSwRDDRLDLEVWDNGPGIPAGQEQAIFAKFARGNKESAiPGVGLGLAICQ 854
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITVTLS-EGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGG-GGTGLGLSIVR 79
|
90 100 110
....*....|....*....|....*....|
gi 1755387238 855 AIVEVHGGEIYARNRPEGGASFHVLLPKET 884
Cdd:pfam02518 80 KLVELLGGTITVESEPGGGTTVTLTLPLAQ 109
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
650-881 |
7.19e-27 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 113.51 E-value: 7.19e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 650 SEEQARLASEREQLRNSL------LAALSHDLRTPLTVlfGQAEILTLDLAAEGSNHAPQASEIRQ---HVLNTT----R 716
Cdd:PRK09303 131 SDELFVLRQENETLLEQLkfkdrvLAMLAHDLRTPLTA--ASLALETLELGQIDEDTELKPALIEQlqdQARRQLeeieR 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 717 LVNNLLDMARIQSGGFNLRKEWLTVEEVVGSALKMLEPGLGGRHIDLSLSDP--LTLIHVDGPLFERVLINLLENAAKYA 794
Cdd:PRK09303 209 LITDLLEVGRTRWEALRFNPQKLDLGSLCQEVILELEKRWLAKSLEIQTDIPsdLPSVYADQERIRQVLLNLLDNAIKYT 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 795 GPRAQTGV----RTSwrdDRLDLEVWDNGPGIPAGQEQAIFAKFARGNKESAIPGVGLGLAICQAIVEVHGGEIYARNRP 870
Cdd:PRK09303 289 PEGGTITLsmlhRTT---QKVQVSICDTGPGIPEEEQERIFEDRVRLPRDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEP 365
|
250
....*....|.
gi 1755387238 871 EGGASFHVLLP 881
Cdd:PRK09303 366 GQGSCFHFTLP 376
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
626-890 |
8.02e-27 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 115.12 E-value: 8.02e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 626 EQQRLLETFTLLvASALERlflteseeqarlaseREQLRNSLLAALSHDLRTPLTVLFGQAEIL---TLDLAAEgSNHAP 702
Cdd:PRK10549 218 ELGRLAQDFNQL-ASTLEK---------------NEQMRRDFMADISHELRTPLAVLRGELEAIqdgVRKFTPE-SVASL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 703 QAseirqHVLNTTRLVNNLLDMARIQSGGFNLRKEWLTVEEVVGSALKMLEPGLGGRHIDLSLSDPLTLIHVDGP----- 777
Cdd:PRK10549 281 QA-----EVGTLTKLVDDLHQLSLSDEGALAYRKTPVDLVPLLEVAGGAFRERFASRGLTLQLSLPDSATVFGDPdrlmq 355
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 778 LFervlINLLENAAKYAGPRAQTGVRTSWRDDRLDLEVWDNGPGIPAGQEQAIFAKFAR--GNKESAIPGVGLGLAICQA 855
Cdd:PRK10549 356 LF----NNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRteGSRNRASGGSGLGLAICLN 431
|
250 260 270
....*....|....*....|....*....|....*
gi 1755387238 856 IVEVHGGEIYARNRPEGGASFHVLLPKETPPELDI 890
Cdd:PRK10549 432 IVEAHNGRIIAAHSPFGGVSITVELPLERDLQREV 466
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
645-887 |
1.48e-26 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 112.25 E-value: 1.48e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 645 LFLTESEEQARLasEREQLRNSLLAA-------LSHDLRTPLTVLFGQAEILTLDLAAEGSNHapQASEIRQHVLNTTRL 717
Cdd:COG3852 111 LVLRDITERKRL--ERELRRAEKLAAvgelaagLAHEIRNPLTGIRGAAQLLERELPDDELRE--YTQLIIEEADRLNNL 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 718 VNNLLDMARIQSggfnLRKEWLTVEEVVGSALKMLEPGLGGR-HIDLSLSDPLTLIHVDGPLFERVLINLLENAAKYAGP 796
Cdd:COG3852 187 VDRLLSFSRPRP----PEREPVNLHEVLERVLELLRAEAPKNiRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNAAEAMPE 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 797 RAQTGVRTSWR----------DDRLDLEVWDNGPGIPAGQEQAIFAKFARGnKESaipGVGLGLAICQAIVEVHGGEIYA 866
Cdd:COG3852 263 GGTITIRTRVErqvtlgglrpRLYVRIEVIDNGPGIPEEILDRIFEPFFTT-KEK---GTGLGLAIVQKIVEQHGGTIEV 338
|
250 260
....*....|....*....|.
gi 1755387238 867 RNRPEGGASFHVLLPKETPPE 887
Cdd:COG3852 339 ESEPGKGTTFRIYLPLEQAEE 359
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
661-884 |
8.83e-24 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 105.38 E-value: 8.83e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 661 EQLRNSLLAALSHDLRTPLTvlfgqaeilTLDLAAEGSNhaPQASEIRQHVLNTTRLVNNLLD--MARIQSG-GFNLRKE 737
Cdd:PRK09467 226 EDDRTLLMAGVSHDLRTPLT---------RIRLATEMMS--EEDGYLAESINKDIEECNAIIEqfIDYLRTGqEMPMEMA 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 738 WLT--VEEVVGSalkmlEPGLGgRHIDLSLSDPLTLIHVDGPLFERVLINLLENAAKYAGPRAQtgVRTSWRDDRLDLEV 815
Cdd:PRK09467 295 DLNalLGEVIAA-----ESGYE-REIETALQPGPIEVPMNPIAIKRALANLVVNAARYGNGWIK--VSSGTEGKRAWFQV 366
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1755387238 816 WDNGPGIPAGQEQAIFAKFARGNKESAIPGVGLGLAICQAIVEVHGGEIYARNRPEGGASFHVLLPKET 884
Cdd:PRK09467 367 EDDGPGIPPEQLKHLFQPFTRGDSARGSSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPLTT 435
|
|
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
641-881 |
5.73e-21 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 97.13 E-value: 5.73e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 641 ALERLfLTESEEQarlaseREQLRNSLLAALSHDLRTPLTVLFGQAEILTLDlaaEGSNHAPQASEIRQHVLN-TTRLVN 719
Cdd:COG5808 225 LLERV-IQEINTQ------KLELIGTFAASTAHEIRNPLTSIKGFIQLLQEK---YPELEDQKYFDIIQEEIQrINQIVS 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 720 NLLDMARIQSggfnlrKEWLTVE--EVVGSALKMLEPGLGGRHIDLSLSDPL--TLIHVDGPLFERVLINLLENAAKYAG 795
Cdd:COG5808 295 EFLVLGKPTA------KKLELDDlnELIEEILSIIDSEANLKNIRVEKQSLDepLHIKCDKDRIKQVLLNLIKNAIEAMK 368
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 796 PRAQTGVRTSWRDDRLDLEVWDNGPGIPAGQEQAIFAKFARGNKEsaipGVGLGLAICQAIVEVHGGEIYARNRPEGGAS 875
Cdd:COG5808 369 EGGKLTISIENDDEKAVIEVIDNGEGIPEDIIDEIFEPFVTTKEG----GTGLGLSVCKRIVEMHGGEIDIESEEGKGTT 444
|
....*.
gi 1755387238 876 FHVLLP 881
Cdd:COG5808 445 FTIRLP 450
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
653-881 |
6.98e-21 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 97.73 E-value: 6.98e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 653 QARLASEREqlrnsLLAALSHDLRTPLTVLFGQAEILTldlaAEGSNHAPQ--ASEIRQHVLNTTRLVNNLLDMARIQsg 730
Cdd:PRK11360 384 QERLAALGE-----LVAGVAHEIRNPLTAIRGYVQIWR----QQTSDPPSQeyLSVVLREVDRLNKVIDQLLEFSRPR-- 452
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 731 gfnlRKEWLTVE--EVVGSALKMLEPGLGGRHIDL--SLSDPLTLIHVDGPLFERVLINLLENAAKYAGPRAQTGVRTsW 806
Cdd:PRK11360 453 ----ESQWQPVSlnALVEEVLQLFQTAGVQARVDFetELDNELPPIWADPELLKQVLLNILINAVQAISARGKIRIRT-W 527
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1755387238 807 R--DDRLDLEVWDNGPGIPAGQEQAIFAKFARgNKESaipGVGLGLAICQAIVEVHGGEIYARNRPEGGASFHVLLP 881
Cdd:PRK11360 528 QysDGQVAVSIEDNGCGIDPELLKKIFDPFFT-TKAK---GTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLP 600
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
639-881 |
1.03e-20 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 95.83 E-value: 1.03e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 639 ASALERLFLTESeeqaRLASEREQLRNS---LLAALSHDLRTPLTVLFGQAEILTLDLAAEgsnhaPQA--SEIRQhvLN 713
Cdd:PRK10604 188 GSSLERLGVAFN----QMADNINALIASkkqLIDGIAHELRTPLVRLRYRLEMSDNLSAAE-----SQAlnRDIGQ--LE 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 714 TtrLVNNLLDMARIQSGGFNLRKEWLTVEEVVGSALKMLEPGLGGRHIDLSLSDPLTLIHVDGPLFERVLINLLENAAKY 793
Cdd:PRK10604 257 A--LIEELLTYARLDRPQNELHLSEPDLPAWLSTHLADIQAVTPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRY 334
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 794 AGPRAQTGVrtSWRDDRLDLEVWDNGPGIPAGQEQAIFAKFAR--GNKESAIPGVGLGLAICQAIVEVHGGEIYARNRPE 871
Cdd:PRK10604 335 AHSRVRVSL--LLDGNQACLIVEDDGPGIPPEERERVFEPFVRldPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESEL 412
|
250
....*....|
gi 1755387238 872 GGASFHVLLP 881
Cdd:PRK10604 413 GGARFSFSWP 422
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
779-881 |
4.67e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 85.98 E-value: 4.67e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 779 FERVLINLLENAAKYAGPRAQTGVRTSWRDDRLDLEVWDNGPGIPAGQEQAIFAKFAR--GNKESAIPGVGLGLAICQAI 856
Cdd:cd16946 5 LQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRveSSRNRASGGSGLGLAICHNI 84
|
90 100
....*....|....*....|....*
gi 1755387238 857 VEVHGGEIYARNRPEGGASFHVLLP 881
Cdd:cd16946 85 ALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
669-881 |
5.38e-20 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 93.99 E-value: 5.38e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 669 AALSHDLRTPLTVLFGQAEILtldLAAEGSN-HAPQASEIRQHVLN-TTRLVNNLLDMARIQSGGFNLRKEWLTVEEVVG 746
Cdd:TIGR01386 246 ADLAHELRTPLTNLLGQTQVA---LSQPRTGeEYREVLESNLEELErLSRMVSDMLFLARADNGQLALERVRLDLAAELA 322
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 747 SALKMLEPGLGGRHIDLSLSDPLTLiHVDGPLFERVLINLLENAAKYAGPRAQTGVRTSWRDDRLDLEVWDNGPGIPAGQ 826
Cdd:TIGR01386 323 KVAEYFEPLAEERGVRIRVEGEGLV-RGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPGIPPEH 401
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 827 EQAIFAKF-----ARGNKESaipGVGLGLAICQAIVEVHGGEIYArNRPEGGASFHVLLP 881
Cdd:TIGR01386 402 LSRLFDRFyrvdpARSNSGE---GTGLGLAIVRSIMEAHGGRASA-ESPDGKTRFILRFP 457
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
780-881 |
5.62e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 85.91 E-value: 5.62e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 780 ERVLINLLENA--AKYAGP--RAQTGVRTSWRDDR-LDLEVWDNGPGIPAGQEQAIFAKFARGNKEsaipGVGLGLAICQ 854
Cdd:cd16920 2 QQVLINLVRNGieAMSEGGceRRELTIRTSPADDRaVTISVKDTGPGIAEEVAGQLFDPFYTTKSE----GLGMGLSICR 77
|
90 100
....*....|....*....|....*..
gi 1755387238 855 AIVEVHGGEIYARNRPEGGASFHVLLP 881
Cdd:cd16920 78 SIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
647-887 |
8.16e-20 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 95.09 E-value: 8.16e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 647 LTESEEQARLASEREQLRnslLAALSHDLRTPLTVLFGQAEIL-TLDLAAEGSNHAPQAseiRQHVLNTTRLVNNLLDMA 725
Cdd:PRK15347 384 LAEAKQRAEQANKRKSEH---LTTISHEIRTPLNGVLGALELLqNTPLTAEQMDLADTA---RQCTLSLLAIINNLLDFS 457
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 726 RIQSGGFNLRKEWLTVEEVVGSAlkMLEPGLGGRHIDLSLSD------PLTLiHVDGPLFERVLINLLENAAKYAgPRAQ 799
Cdd:PRK15347 458 RIESGQMTLSLEETALLPLLDQA--MLTIQGPAQSKSLTLRTfvgahvPLYL-HLDSLRLRQILVNLLGNAVKFT-ETGG 533
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 800 TGVRTSWRDDRLDLEVWDNGPGIPAGQEQAIFAKFARGNKESAipGVGLGLAICQAIVEVHGGEIYARNRPEGGASFHVL 879
Cdd:PRK15347 534 IRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQ--GTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLV 611
|
250
....*....|
gi 1755387238 880 LPKE--TPPE 887
Cdd:PRK15347 612 LPLNeyAPPE 621
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
661-887 |
1.10e-19 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 93.50 E-value: 1.10e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 661 EQLRNS--------LLAALSHDLRTPLTVLFGQAEILtldlaaEGSNHAPQA-------SEIRQhvLNTtrLVNNLLDMA 725
Cdd:COG5809 259 ELLRKSeklsvvgeLAAGIAHEIRNPLTSLKGFIQLL------KDTIDEEQKtyldimlSELDR--IES--IISEFLVLA 328
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 726 RIQSGGFNLRKewltVEEVVGSALKMLEPG--LGGRHIDLSLSDPLTLIHVDGPLFERVLINLLENAAKYAGPRAQTGVR 803
Cdd:COG5809 329 KPQAIKYEPKD----LNTLIEEVIPLLQPQalLKNVQIELELEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIE 404
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 804 TSW-RDDRLDLEVWDNGPGIPAGQEQAIFAKFARgNKESaipGVGLGLAICQAIVEVHGGEIYARNRPEGGASFHVLLPK 882
Cdd:COG5809 405 TKAeDDDKVVISVTDEGCGIPEERLKKLGEPFYT-TKEK---GTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPI 480
|
....*
gi 1755387238 883 ETPPE 887
Cdd:COG5809 481 KLSEQ 485
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
781-881 |
1.19e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 84.81 E-value: 1.19e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 781 RVLINLLENAAKYAGprAQTGVRTSWRDDRLDLEVWDNGPGIPAGQEQAIFAKFARGNKESAIPGVGLGLAICQAIVEVH 860
Cdd:cd16950 3 RVLSNLVDNALRYGG--GWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGTSGTGLGLAIVQRISDAH 80
|
90 100
....*....|....*....|.
gi 1755387238 861 GGEIYARNRPEGGASFHVLLP 881
Cdd:cd16950 81 GGSLTLANRAGGGLCARIELP 101
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
782-881 |
3.08e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 83.53 E-value: 3.08e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 782 VLINLLENAAKYAGPRAQTGVRTSWRDDRLD--LEVWDNGPGIPAGQEQAIFAKFARGNKESAIPGVGLGLAICQAIVEV 859
Cdd:cd16921 4 VLTNLLGNAIKFRRPRRPPRIEVGAEDVGEEwtFYVRDNGIGIDPEYAEKVFGIFQRLHSREEYEGTGVGLAIVRKIIER 83
|
90 100
....*....|....*....|..
gi 1755387238 860 HGGEIYARNRPEGGASFHVLLP 881
Cdd:cd16921 84 HGGRIWLESEPGEGTTFYFTLP 105
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
652-882 |
3.34e-19 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 91.83 E-value: 3.34e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 652 EQARLASEREQLRNSL---------LAALSHDLRTPLTVLFGQAEILTLDLAAEGSNHApqASEIRQHVLNTTRLVNNLL 722
Cdd:PRK11100 235 ELRELAQALESMRVKLegkayveqyVQTLTHELKSPLAAIRGAAELLQEDPPPEDRARF--TGNILTQSARLQQLIDRLL 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 723 DMARIQSGGFNLRKEWLTVEEVVGSALKMLEPGLGGRHIDLSLSDPLTLIHVDGPLFERVLINLLENAAKYAGPRAQTGV 802
Cdd:PRK11100 313 ELARLEQRQELEVLEPVALAALLEELVEAREAQAAAKGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITL 392
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 803 RTSWRDDRLDLEVWDNGPGIPAGQEQAIFAKF---AR---GNKESaipgvGLGLAICQAIVEVHGGEIYARNRPEGGASF 876
Cdd:PRK11100 393 SAEVDGEQVALSVEDQGPGIPDYALPRIFERFyslPRpanGRKST-----GLGLAFVREVARLHGGEVTLRNRPEGGVLA 467
|
....*.
gi 1755387238 877 HVLLPK 882
Cdd:PRK11100 468 TLTLPR 473
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
653-886 |
9.31e-19 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 91.89 E-value: 9.31e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 653 QARLASER-EQLRNSLLAALSHDLRTPLTVLFGQAEILTLDLAAEGSNHAPQAseIRQHVLNTTRLVNNLLDMARIQSGG 731
Cdd:PRK11466 432 QARAEAEKaSQAKSAFLAAMSHEIRTPLYGILGTAQLLADNPALNAQRDDLRA--ITDSGESLLTILNDILDYSAIEAGG 509
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 732 FN--LRKEWLTVEEVVGSALKMLEPGLGGRHIDLS--LSDPL-TLIHVDGPLFERVLINLLENAAKYAgPRAQTGVRTSW 806
Cdd:PRK11466 510 KNvsVSDEPFEPRPLLESTLQLMSGRVKGRPIRLAtdIADDLpTALMGDPRRIRQVITNLLSNALRFT-DEGSIVLRSRT 588
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 807 RDDRLDLEVWDNGPGIPAGQEQAIFAKFARGNKESAipGVGLGLAICQAIVEVHGGEIYARNRPEGGASFHVLLP--KET 884
Cdd:PRK11466 589 DGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKRG--GTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPlrVAT 666
|
..
gi 1755387238 885 PP 886
Cdd:PRK11466 667 AP 668
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
780-881 |
1.36e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 81.71 E-value: 1.36e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 780 ERVLINLLENAAKYAGPRAQTGVRTSwrDDRLDLEVWDNGPGIPAGQEQAIFAKFAR--GNKESAIPGVGLGLAICQAIV 857
Cdd:cd16939 2 ARALDNLLRNALRYAHRTVRIALLVS--GGRLTLIVEDDGPGIPAAARERVFEPFVRldPSRDRATGGFGLGLAIVHRVA 79
|
90 100
....*....|....*....|....
gi 1755387238 858 EVHGGEIYARNRPEGGASFHVLLP 881
Cdd:cd16939 80 LWHGGHVECDDSELGGACFRLTWP 103
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
611-881 |
1.50e-18 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 89.46 E-value: 1.50e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 611 LVIVEPGNLRQLMIpeqqRLLETFTLLVASALErLFLTESEEQARLASEREQLRNSLLAAL-------SHDLRTPLTVLF 683
Cdd:PRK10364 182 LVSAQAREQRNTLI----ILFALATVLLASLLA-FFWYRRYLRSRQLLQDEMKRKEKLVALghlaagvAHEIRNPLSSIK 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 684 GQAEILTLDLAAEGSNHApQASEIRQHVLNTTRLVNNLLDMARIQsggfNLRKEWLTVEEVVGSALKMLEPGLGGRHIDL 763
Cdd:PRK10364 257 GLAKYFAERAPAGGEAHQ-LAQVMAKEADRLNRVVSELLELVKPT----HLALQAVDLNDLINHSLQLVSQDANSREIQL 331
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 764 SL--SDPLTLIHVDGPLFERVLINLLENAAKYAGPRAQTGVRTSWRDDRLDLEVWDNGPGIPAGQEQAIFAKFARGNKEs 841
Cdd:PRK10364 332 RFtaNDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAE- 410
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 1755387238 842 aipGVGLGLAICQAIVEVHGGEIYARNRPEGGASFHVLLP 881
Cdd:PRK10364 411 ---GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 447
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
779-881 |
1.51e-18 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 81.77 E-value: 1.51e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 779 FERVLINLLENAAKYA--GPRAQTGVRTSwRDDRLDLEVWDNGPGIPAGQEQAIFAKFARGNKES--AIPGVGLGLAICQ 854
Cdd:cd16925 5 YERVVLNLLSNAFKFTpdGGRIRCILEKF-RLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSStrAHGGTGLGLSIVK 83
|
90 100
....*....|....*....|....*..
gi 1755387238 855 AIVEVHGGEIYARNRPEGGASFHVLLP 881
Cdd:cd16925 84 EFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
779-882 |
1.97e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 81.22 E-value: 1.97e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 779 FERVLINLLENAAKYAgpRAQTGVRTSWRDDRLDLEVWDNGPGIPAGQEQAIFAKFARGN--KESAIPGVGLGLAICQAI 856
Cdd:cd16949 1 LARALENVLRNALRYS--PSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDsaRDRESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*.
gi 1755387238 857 VEVHGGEIYARNRPEGGASFHVLLPK 882
Cdd:cd16949 79 IEQHGGKIKASNRKPGGLRVRIWLPA 104
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
777-881 |
3.21e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 80.93 E-value: 3.21e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 777 PLFERVLINLLENAAKYAGPRAQTGVRTSWRDDRLDLEVWDNGPGIPAGQEQAIFAKF--ARGNKEsaipGVGLGLAICQ 854
Cdd:cd16943 2 SQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFftTKPVGE----GTGLGLSLSY 77
|
90 100
....*....|....*....|....*..
gi 1755387238 855 AIVEVHGGEIYARNRPEGGASFHVLLP 881
Cdd:cd16943 78 RIIQKHGGTIRVASVPGGGTRFTIILP 104
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
638-884 |
3.37e-18 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 87.33 E-value: 3.37e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 638 VASALERLF--LTESEEQARLasereqlrnsLLAALSHDLRTPLtvlfgqAEI-LTLDLAAEgsNHAPQASEIRQHVLNT 714
Cdd:PRK10755 119 VTSALNQLVsrLTSTLDQERL----------FTADVAHELRTPL------AGIrLHLELLEK--QHHIDVAPLIARLDQM 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 715 TRLVNNLLDMARIQ---SGGFNLRKEWltVEEVVGSALKMLEPGLGGRH--IDLSLSDPLTLIHVDGPLFERVLINLLEN 789
Cdd:PRK10755 181 MHTVEQLLQLARAGqsfSSGHYQTVKL--LEDVILPSQDELSEMLEQRQqtLLLPESAADITVQGDATLLRLLLRNLVEN 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 790 AAKYAGPRAQTGVRTSWRDDRLDLEVWDNGPGIPAGQEQAIFAKFARgnKESAIPGVGLGLAICQAIVEVHGGEIYARNR 869
Cdd:PRK10755 259 AHRYSPEGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVR--MDSRYGGIGLGLSIVSRITQLHHGQFFLQNR 336
|
250
....*....|....*.
gi 1755387238 870 PE-GGASFHVLLPKET 884
Cdd:PRK10755 337 QErSGTRAWVWLPKAQ 352
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
664-883 |
4.23e-18 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 89.79 E-value: 4.23e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 664 RNSLLAALSHDLRTPLTVLFGQAEILT-LDLAAEGSNHAPQ-ASEIRQHVLNttrLVNNLLDMARIQSGGFNLRKEWLTV 741
Cdd:PRK09959 712 KSQFLATMSHEIRTPISSIMGFLELLSgSGLSKEQRVEAISlAYATGQSLLG---LIGEILDVDKIESGNYQLQPQWVDI 788
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 742 EEVVGSALKMLEPGLGGRHIDLSLSDPLT---LIHVDGPLFERVLINLLENAAKYAGPRAqTGVRTSWR--DDR---LDL 813
Cdd:PRK09959 789 PTLVQNTCHSFGAIAASKSIALSCSSTFPdhyLVKIDPQAFKQVLSNLLSNALKFTTEGA-VKITTSLGhiDDNhavIKM 867
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 814 EVWDNGPGIPAGQEQAIFAKFARGNKESAIPGVGLGLAICQAIVEVHGGEIYARNRPEGGASFHVLLPKE 883
Cdd:PRK09959 868 TIMDSGSGLSQEEQQQLFKRYSQTSAGRQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPVE 937
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
759-880 |
6.48e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 80.75 E-value: 6.48e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 759 RHIDLSLS-DPLTLIHVDGPLFERVLINLLENAAKYAGPRAQTGVRTSwrDDRLDLEVWDNGPGIPAGQEQAIFAkfaRG 837
Cdd:cd16954 17 KGVSISLDiSPELRFPGERNDLMELLGNLLDNACKWCLEFVEVTARQT--DGGLHLIVDDDGPGVPESQRSKIFQ---RG 91
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1755387238 838 NK-ESAIPGVGLGLAICQAIVEVHGGEIYARNRPEGGASFHVLL 880
Cdd:cd16954 92 QRlDEQRPGQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
782-881 |
1.92e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 78.69 E-value: 1.92e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 782 VLINLLENAAKYAgPRAQTGVRTSWRDD-----RLDLEVWDNGPGIPAGQEQAIFAKFARGnkESAIP----GVGLGLAI 852
Cdd:cd16922 4 ILLNLLGNAIKFT-EEGEVTLRVSLEEEeedgvQLRFSVEDTGIGIPEEQQARLFEPFSQA--DSSTTrkygGTGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 1755387238 853 CQAIVEVHGGEIYARNRPEGGASFHVLLP 881
Cdd:cd16922 81 SKKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
449-883 |
3.69e-17 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 84.51 E-value: 3.69e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 449 VVATIINVVSFDLFFIAPRGTLAVSDVQYLLTFAVMLSVGLIIGNLTAGVRYQARIARYREQRTRhLYEMSKALAVGRSA 528
Cdd:COG3290 17 LILILLLLLLIILLLILLLVLLLLLFLLFVIILLLLLLILLLILLLLLLLLLAALLLKLLEEIAR-LVEEREAVLESIRE 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 529 RDIAATSQQFIASTFHARGLLLLPDEHGKlqapqPLAEITPwdEAIARWSFDKGLPAGAGTdtlpgVPYQILPLRTAGKT 608
Cdd:COG3290 96 GVIAVDRDGRITLINDAARRLLGLDAIGR-----PIDEVLA--EVLETGERDEEILLNGRV-----LVVNRVPIRDDGRV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 609 LGLVIVepgnLRQlmIPEQQRLLETftllvasalerlfLTESEEQArlaserEQLRnsllaALSHDLRTPLTVLFGQAEI 688
Cdd:COG3290 164 VGAVAT----FRD--RTELERLEEE-------------LEGVKELA------EALR-----AQRHDFRNHLHTISGLLQL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 689 LTLDlaaegsnhapqasEIRQHVLNTTRLVNNLLDMARIQSGgfnlrkewltvEEVVGSAL-----KMLEpglggRHIDL 763
Cdd:COG3290 214 GEYD-------------EALEYIDEISEELQELIDSLLSRIG-----------NPVLAALLlgkaaRARE-----RGIDL 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 764 SLS--DPLTLIHVDGPLFERVLINLLENA----AKYAGPRAQTGVRTSWRDDRLDLEVWDNGPGIPAGQEQAIFAkfaRG 837
Cdd:COG3290 265 TIDidSDLPDLPLSDTDLVTILGNLLDNAieavEKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFE---RG 341
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 1755387238 838 N--KESAipGVGLGLAICQAIVEVHGGEIYARNRPEGGASFHVLLPKE 883
Cdd:COG3290 342 FstKLGE--GRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKE 387
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
780-880 |
8.24e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 76.73 E-value: 8.24e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 780 ERVLINLLENAAKYAGPRAQTGVRTS--WRDDRLDLEVWDNGPGIPAGQEQAIFAKFARgNKESAiPGVGLGLAICQAIV 857
Cdd:cd16976 2 QQVLMNLLQNALDAMGKVENPRIRIAarRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFT-TKPVG-KGTGLGLSISYGIV 79
|
90 100
....*....|....*....|...
gi 1755387238 858 EVHGGEIYARNRPEGGASFHVLL 880
Cdd:cd16976 80 EEHGGRLSVANEEGAGARFTFDL 102
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
772-873 |
3.80e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 75.13 E-value: 3.80e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 772 IHVDGPLFERVLINLLENAAKYAGPRAQTGVRTSWRDDRLdLEVWDNGPGIPAGQEQAIFAKFARGNKESAiPGVGLGLA 851
Cdd:cd16940 7 VQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAV-IRVEDNGPGIDEEELEALFERFYRSDGQNY-GGSGLGLS 84
|
90 100
....*....|....*....|..
gi 1755387238 852 ICQAIVEVHGGEIYARNRPEGG 873
Cdd:cd16940 85 IVKRIVELHGGQIFLGNAQGGG 106
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
654-881 |
2.11e-15 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 80.56 E-value: 2.11e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 654 ARLASEREQLRNsLLAALSHDLRTPLTVLFGQAEILTL-DLAAEGSNHAPQASEirqHVLNTTRLVNNLLDMARIQSGGF 732
Cdd:TIGR03785 476 ARLRQYTHYLEN-MSSRLSHELRTPVAVVRSSLENLELqALEQEKQKYLERARE---GTERLSMILNNMSEATRLEQAIQ 551
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 733 NLRKEWLTVEEVVGSALKMLEPGLGGRHIDLSLSDPLTLIHVDGPLFERVLINLLENAAKYAGPRAQTGVRTSWRDDRLD 812
Cdd:TIGR03785 552 SAEVEDFDLSEVLSGCMQGYQMTYPPQRFELNIPETPLVMRGSPELIAQMLDKLVDNAREFSPEDGLIEVGLSQNKSHAL 631
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1755387238 813 LEVWDNGPGIPAGQEQAIFAKFA--RGNKESAIPGVGLGLAICQAIVEVHGGEIYARNRPEG-GASFHVLLP 881
Cdd:TIGR03785 632 LTVSNEGPPLPEDMGEQLFDSMVsvRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAENRQQNdGVVFRISLP 703
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
640-873 |
5.34e-15 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 78.54 E-value: 5.34e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 640 SALERLFlteSEEQARLASEReqlRNSLLAAlsHDLRTPLTVLFGQAEILTLdlaaegSNHAPQAseiRQHVL------- 712
Cdd:PRK10337 221 EALNQLF---ARTHAMMVRER---RFTSDAA--HELRSPLAALKVQTEVAQL------SDDDPQA---RKKALlqlhagi 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 713 -NTTRLVNNLLDMARIQSGGFNLRKEWLTVEEVVGSALKMLEPGLGGRHIDLSLSDPLTLIHVDG-PLFERVLI-NLLEN 789
Cdd:PRK10337 284 dRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSAVMDIYHTAQQAGIDVRLTLNAHPVIRTGqPLLLSLLVrNLLDN 363
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 790 AAKYAGPRAQTGVRTSWRDdrldLEVWDNGPGIPAGQEQAIFAKFARGNKESAiPGVGLGLAICQAIVEVHGGEIYARNR 869
Cdd:PRK10337 364 AIRYSPQGSVVDVTLNARN----FTVRDNGPGVTPEALARIGERFYRPPGQEA-TGSGLGLSIVRRIAKLHGMNVSFGNA 438
|
....
gi 1755387238 870 PEGG 873
Cdd:PRK10337 439 PEGG 442
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
781-881 |
2.19e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 69.72 E-value: 2.19e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 781 RVLINLLENAAKYAGPRAQTGVRTSWRDDRLDLEVWDNGPGIPAGQEQAIFAKFARGNKESAIPGVGLGLAICQAIVEVH 860
Cdd:cd16923 3 RVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNTEGAGLGLSIAKAIIELH 82
|
90 100
....*....|....*....|.
gi 1755387238 861 GGEIYARNRPEgGASFHVLLP 881
Cdd:cd16923 83 GGSASAEYDDN-HDLFKVRLP 102
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
780-881 |
5.10e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 65.88 E-value: 5.10e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 780 ERVLINLLENAAKYAGP---------RAQTGVRTSWRDDRL--DLEVWDNGPGIPAGQEQAIFAKFARGNKEsaipGVGL 848
Cdd:cd16918 2 IQVFLNLVRNAAQALAGsggeiilrtRTQRQVTLGHPRHRLalRVSVIDNGPGIPPDLQDTIFYPMVSGREN----GTGL 77
|
90 100 110
....*....|....*....|....*....|...
gi 1755387238 849 GLAICQAIVEVHGGEIYARNRPeGGASFHVLLP 881
Cdd:cd16918 78 GLAIAQNIVSQHGGVIECDSQP-GHTVFSVSLP 109
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
656-889 |
1.52e-12 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 70.82 E-value: 1.52e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 656 LASERE---QLRNSLlAALSHDLRTPLTVL--------------FGQAEILTLDlaaegsnhapQASEIRQHVlnttrlv 718
Cdd:PRK10815 256 LKNERErytKYRTTL-TDLTHSLKTPLAVLqstlrslrsgkqmsVEQAEPIMLE----------QISRISQQI------- 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 719 NNLLDMARIQSGGFNLRKEWLTVEEVVGSALKMLEPGLGGRHIDLSL--SDPLTLI--HVDgplFERVLINLLENAAKYA 794
Cdd:PRK10815 318 GYYLHRASMRSEHNLLSRELHSVAPLLDNLTSALNKVYQRKGVNITLdiSPEITFVgeKND---FMEVMGNVLDNACKYC 394
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 795 GPRAQTGVRTSwrDDRLDLEVWDNGPGIPAGQEQAIFAkfaRGNKESAI-PGVGLGLAICQAIVEVHGGEIYARNRPEGG 873
Cdd:PRK10815 395 LEFVEISARQT--DEHLHIVVEDDGPGIPESKRELIFD---RGQRADTLrPGQGLGLSVAREITEQYEGKISAGDSPLGG 469
|
250
....*....|....*.
gi 1755387238 874 ASFHVLLPKETPPELD 889
Cdd:PRK10815 470 ARMEVIFGRQHSTPKD 485
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
778-876 |
6.18e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 62.86 E-value: 6.18e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 778 LFERVLINLLENAAKYAGPRAQTGVRTSWRDDRLDLEVWDNGPGIPAGQEQAIFAKF------ARGNKESaipgvGLGLA 851
Cdd:cd16945 4 LLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFyslprpHSGQKST-----GLGLA 78
|
90 100
....*....|....*....|....*
gi 1755387238 852 ICQAIVEVHGGEIYARNRPEGGASF 876
Cdd:cd16945 79 FVQEVAQLHGGRITLRNRPDGVLAF 103
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
781-881 |
7.64e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 62.59 E-value: 7.64e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 781 RVLINLLENAAKYAGPR-AQTGVRTSWRDDRLDLEVWDNGPGIPAGQEQAIFAKFARGNKESAIPGV--GLGLAICQAIV 857
Cdd:cd16953 3 QVLRNLIGNAISFSPPDtGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQhsGLGLSISRQII 82
|
90 100
....*....|....*....|....*...
gi 1755387238 858 EVHGGEIYARNRPEG----GASFHVLLP 881
Cdd:cd16953 83 EAHGGISVAENHNQPgqviGARFTVQLP 110
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
775-881 |
1.16e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 62.17 E-value: 1.16e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 775 DGPLFERVLINLLENAAKYA----GPRAQTGVRTSW-RDDRLDLEVWDNGPGIPAGQEQAIFAKFARGNKEsaipGVGLG 849
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAIegrpSDVGEVRIRVEAdQDGRIVLIVCDNGKGFPREMRHRATEPYVTTRPK----GTGLG 76
|
90 100 110
....*....|....*....|....*....|..
gi 1755387238 850 LAICQAIVEVHGGEIYARNRPEGGASFHVLLP 881
Cdd:cd16944 77 LAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
785-881 |
2.06e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 61.15 E-value: 2.06e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 785 NLLENA----AKYAGPRAQTGVRTSWRDDRLDLEVWDNGPGIPAGQEQAIFAkfaRGNKESAIPGVGLGLAICQAIVEVH 860
Cdd:cd16915 7 NLIDNAldalAATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFE---RGVSTKGQGERGIGLALVRQSVERL 83
|
90 100
....*....|....*....|.
gi 1755387238 861 GGEIYARNRPEGGASFHVLLP 881
Cdd:cd16915 84 GGSITVESEPGGGTTFSIRIP 104
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
629-887 |
2.22e-11 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 67.78 E-value: 2.22e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 629 RLLETFTLLVASALERLFL-TESEE-QARLA-SEREQLRNSLLAALSHDLRTPLTVLFGQAEIlTLDLAAEGSNHAPQAS 705
Cdd:PRK13837 412 QLLELALDCLAHAIERRRLeTERDAlERRLEhARRLEAVGTLASGIAHNFNNILGAILGYAEM-ALNKLARHSRAARYID 490
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 706 EIRQHVLNTTRLVNNLLDMARIQsggfNLRKEWLTVEEVVGSALKMLEPGLGgRHIDLSLSDPLTLIHVDG-PL-FERVL 783
Cdd:PRK13837 491 EIISAGARARLIIDQILAFGRKG----ERNTKPFDLSELVTEIAPLLRVSLP-PGVELDFDQDQEPAVVEGnPAeLQQVL 565
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 784 INLLENAAKYAGPRAQTGVRTSWRDDR---------------LDLEVWDNGPGIPAGQEQAIFAKF----ARGNkesaip 844
Cdd:PRK13837 566 MNLCSNAAQAMDGAGRVDISLSRAKLRapkvlshgvlppgryVLLRVSDTGAGIDEAVLPHIFEPFfttrAGGT------ 639
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 1755387238 845 gvGLGLAICQAIVEVHGGEIYARNRPEGGASFHVLLPKETPPE 887
Cdd:PRK13837 640 --GLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPPSSKVP 680
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
780-880 |
2.42e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 61.76 E-value: 2.42e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 780 ERVLINLLENAAKYAGPRAQTGVRTSWRDDRLDLEVWDNGPGIPAGQEQAIFAKF--ARGNKESAIPGVGLGLAICQAIV 857
Cdd:cd16947 22 QRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLytLEDSRNSAKQGNGLGLTITKRLA 101
|
90 100
....*....|....*....|...
gi 1755387238 858 EVHGGEIYARNRPEGGASFHVLL 880
Cdd:cd16947 102 ESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
669-882 |
2.72e-11 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 66.72 E-value: 2.72e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 669 AALSHDLRTPLTVLFGQAEIltldlaAEGSNHAPQASEirqHVLNT--------TRLVNNLLDMARIQSGGFNLRKEWLT 740
Cdd:PRK09835 267 ADIAHEIRTPITNLITQTEI------ALSQSRSQKELE---DVLYSnleeltrmAKMVSDMLFLAQADNNQLIPEKKMLD 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 741 VEEVVGSALKMLEPGLGGRHIDLSLSDPLTLIHVDGPLFERVLINLLENAAKYAGPRAQTGVRTSWRDDRLDLEVWDNGP 820
Cdd:PRK09835 338 LADEVGKVFDFFEAWAEERGVELRFVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGT 417
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1755387238 821 GIPAGQEQAIFAKFARGN--KESAIPGVGLGLAICQAIVEVHGGEIYARNRPEgGASFHVLLPK 882
Cdd:PRK09835 418 PIAPEHLPRLFDRFYRVDpsRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDAR-GTRFVISLPR 480
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
647-882 |
3.09e-11 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 66.68 E-value: 3.09e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 647 LTESEEQARlASEREQLRNSLLAALSHDLRTPLTVLFG-----QAEIltldlaaEGSNHAPQA--SEIRQhvLNTtrLVN 719
Cdd:COG5805 271 KKEAEELMA-RSEKLSIAGQLAAGIAHEIRNPLTSIKGflqllQPGI-------EDKEEYFDImlSELDR--IES--IIS 338
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 720 NLLDMARIQSGGF---NLRKewlTVEEVVgsALKMLEPGLGGRHIDLSLSDPLTLIHVDGPLFERVLINLLENAAKyAGP 796
Cdd:COG5805 339 EFLALAKPQAVNKekeNINE---LIQDVV--TLLETEAILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIE-AMP 412
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 797 RAQT-GVRTSWRDDRLDLEVWDNGPGIPAGQEQAIFAKFARgNKESaipGVGLGLAICQAIVEVHGGEIYARNRPEGGAS 875
Cdd:COG5805 413 NGGTiTIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFFT-TKEK---GTGLGLMVSYKIIENHNGTIDIDSKVGKGTT 488
|
....*..
gi 1755387238 876 FHVLLPK 882
Cdd:COG5805 489 FTITLPL 495
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
659-881 |
3.58e-11 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 66.89 E-value: 3.58e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 659 EREQLRNSL----------LAALSHDLRTPLTVLFGQAEILtLD--LAAEGSNHApqaSEIrqHVLNTT--RLVNNLLDM 724
Cdd:PRK11091 268 ERKRYQDALekasrdkttfISTISHELRTPLNGIVGLSRIL-LDteLTAEQRKYL---KTI--HVSAITlgNIFNDIIDM 341
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 725 ARIQSGGFNLRKEWLTVEEVVG-----SALkMLEP-GLggrHIDLSLSDPL-TLIHVDGPLFERVLINLLENAAKYAgpr 797
Cdd:PRK11091 342 DKMERRKLQLDNQPIDFTDFLAdlenlSGL-QAEQkGL---RFDLEPLLPLpHKVITDGTRLRQILWNLISNAVKFT--- 414
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 798 AQTGVRTS-WRD--DRLDLEVWDNGPGIPAGQEQAIFA-----KFARGNKeSAIpGVGLGLAICQAIVEVHGGEIYARNR 869
Cdd:PRK11091 415 QQGGVTVRvRYEegDMLTFEVEDSGIGIPEDELDKIFAmyyqvKDSHGGK-PAT-GTGIGLAVSKRLAQAMGGDITVTSE 492
|
250
....*....|..
gi 1755387238 870 PEGGASFHVLLP 881
Cdd:PRK11091 493 EGKGSCFTLTIH 504
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
650-882 |
3.88e-11 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 66.19 E-value: 3.88e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 650 SEEQ----ARLASEREQL---RNSLLAALSHDLRTPLTVLFGQAEiLTLDLAAEGSnhapqaseIRQHVLNTTR------ 716
Cdd:PRK11006 183 TEGQllmvARDVTQMHQLegaRRNFFANVSHELRTPLTVLQGYLE-MMQDQPLEGA--------LREKALHTMReqtqrm 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 717 --LVNNLLDMARIQSGgfnlrkEWLTVEEVVG--SALKMLEpglggrHIDLSLSDPLTLIH--VDGPLfeRVL------- 783
Cdd:PRK11006 254 egLVKQLLTLSKIEAA------PTIDLNEKVDvpMMLRVLE------REAQTLSQGKHTITfeVDNSL--KVFgnedqlr 319
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 784 ---INLLENAAKYAGPRAQtgVRTSWR--DDRLDLEVWDNGPGIPAGQEQAIFAKFARGNK--ESAIPGVGLGLAICQAI 856
Cdd:PRK11006 320 saiSNLVYNAVNHTPEGTH--ITVRWQrvPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKarSRQTGGSGLGLAIVKHA 397
|
250 260
....*....|....*....|....*.
gi 1755387238 857 VEVHGGEIYARNRPEGGASFHVLLPK 882
Cdd:PRK11006 398 LSHHDSRLEIESEVGKGTRFSFVLPE 423
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
629-874 |
4.06e-11 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 66.63 E-value: 4.06e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 629 RLLETFTLLVASALERLfLTESEEQARLASEREQLRNSLLAA------------LSHDLRTPLTVLfgQAEILTLDLAAE 696
Cdd:COG4192 387 RLLRVFRDQAIEKTQEL-ETEIEERKRIEKNLRQTQDELIQAakmavvgqtmtsLAHELNQPLNAM--SMYLFSAKKALE 463
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 697 GSNHApQASE----IRQHVLNTTRLVNNLLDMARIQSGGFNLrkewLTVEEVVGSALKMLEPGLGGRHIDLSLSDPLtLI 772
Cdd:COG4192 464 QENYA-QLPTsldkIEGLIERMDKIIKSLRQFSRKSDTPLQP----VDLRQVIEQAWELVESRAKPQQITLHIPDDL-MV 537
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 773 HVDGPLFERVLINLLENAAKYAGPRAQTGVRTSWRDDRLDLEVWDNGPGIPAGQEqaIFAKFARgNKESaipGVGLGLAI 852
Cdd:COG4192 538 QGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWPLVDK--LFTPFTT-TKEV---GLGLGLSI 611
|
250 260
....*....|....*....|..
gi 1755387238 853 CQAIVEVHGGEIYARNRPEGGA 874
Cdd:COG4192 612 CRSIMQQFGGDLYLASTLERGA 633
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
640-881 |
2.85e-10 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 63.41 E-value: 2.85e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 640 SALERLFLTeseeQARLASEreqlrnsllaaLSHDLRTPLTVLfgQaeiLTLDLAAEGSNHAPQASEIRqhvLNTTRL-- 717
Cdd:PRK09470 234 TALERMMTS----QQRLLSD-----------ISHELRTPLTRL--Q---LATALLRRRQGESKELERIE---TEAQRLds 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 718 -VNNLLDMARIQSGGfNLRKEWLTVEEVVGSALKMLEPGLGGRHIDLSLSDPLTLIHVDG--PLFERVLINLLENAAKYA 794
Cdd:PRK09470 291 mINDLLVLSRNQQKN-HLERETFKANSLWSEVLEDAKFEAEQMGKSLTVSAPPGPWPINGnpNALASALENIVRNALRYS 369
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 795 gpRAQTGVRTSWRDDRLDLEVWDNGPGIPAGQEQAIFAKF-----ARgNKESAipGVGLGLAICQAIVEVHGGEIYARNR 869
Cdd:PRK09470 370 --HTKIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFyrvdeAR-DRESG--GTGLGLAIVENAIQQHRGWVKAEDS 444
|
250
....*....|..
gi 1755387238 870 PEGGASFHVLLP 881
Cdd:PRK09470 445 PLGGLRLTIWLP 456
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
664-730 |
3.35e-10 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 56.45 E-value: 3.35e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1755387238 664 RNSLLAALSHDLRTPLTVLFGQAEILTLDLAAEgsNHAPQASEIRQHVLNTTRLVNNLLDMARIQSG 730
Cdd:pfam00512 2 KSEFLANLSHELRTPLTAIRGYLELLRDEKLDE--EQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
661-726 |
1.44e-09 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 54.91 E-value: 1.44e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1755387238 661 EQLRNSLLAALSHDLRTPLTVLFGQAEILtLDLAAEGSNHAPQASEIRQHVLNTTRLVNNLLDMAR 726
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELL-EEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
644-881 |
3.37e-09 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 60.76 E-value: 3.37e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 644 RLFLTES-EEQARLASEREQLRNSLLAALSHDLRTPLTVLFGQAEIL-TLDLAAEgsnhapqaseirqhvlnTTRLV--- 718
Cdd:PRK10841 426 RVKMEESlQEMAQAAEQASQSKSMFLATVSHELRTPLYGIIGNLDLLqTKELPKG-----------------VDRLVtam 488
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 719 NN-----------LLDMARIQS-------GGFNLRKewlTVEEVVGSALKM-----------LEPGLGgrhiDLSLSDPL 769
Cdd:PRK10841 489 NNssslllkiisdILDFSKIESeqlkiepREFSPRE---VINHITANYLPLvvkkrlglycfIEPDVP----VALNGDPM 561
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 770 TLihvdgplfERVLINLLENAAKYAgpraQTG-----VRTswRDDRLDLEVWDNGPGIPAGQEQAIFAKF--ARGNKESA 842
Cdd:PRK10841 562 RL--------QQVISNLLSNAIKFT----DTGcivlhVRV--DGDYLSFRVRDTGVGIPAKEVVRLFDPFfqVGTGVQRN 627
|
250 260 270
....*....|....*....|....*....|....*....
gi 1755387238 843 IPGVGLGLAICQAIVEVHGGEIYARNRPEGGASFHVLLP 881
Cdd:PRK10841 628 FQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIP 666
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
652-886 |
3.48e-09 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 60.63 E-value: 3.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 652 EQARLASEreqlrnsLLAALSHDLRTPLTVLFGQA-EILTLDLaaegsnHAPQaseiRQHVLNTTRLVNNL-------LD 723
Cdd:PRK11107 288 EAARIKSE-------FLANMSHELRTPLNGVIGFTrQTLKTPL------TPTQ----RDYLQTIERSANNLlaiindiLD 350
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 724 MARIQSGG-------FNLRKewlTVEEVV----GSAL-KMLEPGLggrHIDLSLSDpltliHVDG-PL-FERVLINLLEN 789
Cdd:PRK11107 351 FSKLEAGKlvlenipFSLRE---TLDEVVtllaHSAHeKGLELTL---NIDPDVPD-----NVIGdPLrLQQIITNLVGN 419
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 790 AAKYAgPRAQTGVR---TSWRDDRLDLE--VWDNGPGIPAGQEQAIFAKFarGNKESAIP----GVGLGLAICQAIVEVH 860
Cdd:PRK11107 420 AIKFT-ESGNIDILvelRALSNTKVQLEvqIRDTGIGISERQQSQLFQAF--RQADASISrrhgGTGLGLVITQKLVNEM 496
|
250 260
....*....|....*....|....*.
gi 1755387238 861 GGEIYARNRPEGGASFHVLLPKETPP 886
Cdd:PRK11107 497 GGDISFHSQPNRGSTFWFHLPLDLNP 522
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
664-730 |
4.23e-09 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 53.34 E-value: 4.23e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1755387238 664 RNSLLAALSHDLRTPLTVLFGQAEIL-TLDLAAEgsnHAPQASEIRQHVLNTTRLVNNLLDMARIQSG 730
Cdd:smart00388 2 KREFLANLSHELRTPLTAIRGYLELLlDTELSEE---QREYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
782-891 |
1.44e-08 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 58.39 E-value: 1.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 782 VLINLLENAAKYAG--PRAQTGVRTSWRDDRLDLEVWDNGPGIPAGQEQAIFAK-FA-RGNkesaipGVGLGLAICQAIV 857
Cdd:PRK11086 437 ILGNLIENALEAVGgeEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKgYStKGS------NRGVGLYLVKQSV 510
|
90 100 110
....*....|....*....|....*....|....
gi 1755387238 858 EVHGGEIYARNRPEGGASFHVLLPKEtpPELDIH 891
Cdd:PRK11086 511 ENLGGSIAVESEPGVGTQFFVQIPWD--GERSNR 542
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
775-874 |
6.92e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 51.31 E-value: 6.92e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 775 DGPLFERVLINLLENAAKYAgpRAQTGVRTSWRDDR--LDLEVWDNGPGIPAGQEQAIFAKFARGNKESAIPG-VGLGLA 851
Cdd:cd16975 1 DTLLLSRALINIISNACQYA--PEGGTVSISIYDEEeyLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGhYGMGLY 78
|
90 100
....*....|....*....|...
gi 1755387238 852 ICQAIVEVHGGEIYARNRPEGGA 874
Cdd:cd16975 79 IAKNLVEKHGGSLIIENSQKGGA 101
|
|
| GAF_3 |
pfam13492 |
GAF domain; |
530-644 |
8.64e-08 |
|
GAF domain;
Pssm-ID: 433253 [Multi-domain] Cd Length: 129 Bit Score: 51.60 E-value: 8.64e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 530 DIAATSQQFIASTFHA-RGLLLLPDE-----------HGKLQAPQPLAEITP-WDEAIARWSFDKGlPAGAGTDTLPGVP 596
Cdd:pfam13492 4 EILEALLKLLVRLLGAeRAAVYLLDEdgnklqvaagyDGEPDPSESLDADSPlARRALSSGEPISG-LGSAGEDGLPDGP 82
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1755387238 597 YQILPLRTAGKTLGLVIVEPGNLRQLmIPEQQRLLETFTLLVASALER 644
Cdd:pfam13492 83 ALVVPLVAGRRVIGVLALASSKPRAF-DAEDLRLLESLAAQIATAIEN 129
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
622-881 |
9.03e-08 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 55.09 E-value: 9.03e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 622 LMIPEQQRLLEtftlLVASAL-ERLFLTE---SEEQARLASE-----REQLRNSLLAALSHDLRTPLTVLFGQAEILTLD 692
Cdd:PRK11073 83 LVIDGRSHILS----LTAQRLpEGMILLEmapMDNQRRLSQEqlqhaQQVAARDLVRGLAHEIKNPLGGLRGAAQLLSKA 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 693 LAAegsnhaPQASEIRQHVLNTTRLVNNLLDmaRI---QSGGfnlRKEWLTVEEVVGSALKMLEPGLGG-----RHIDLS 764
Cdd:PRK11073 159 LPD------PALTEYTKVIIEQADRLRNLVD--RLlgpQRPG---THVTESIHKVAERVVQLVSLELPDnvrliRDYDPS 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 765 LSDpltlIHVDGPLFERVLINLLENAAKYAGP-------RAQTGVRTSWRDDRLDL----EVWDNGPGIPAGQEQAIFAK 833
Cdd:PRK11073 228 LPE----LAHDPDQIEQVLLNIVRNALQALGPeggtitlRTRTAFQLTLHGERYRLaariDIEDNGPGIPPHLQDTLFYP 303
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1755387238 834 FARGnKESaipGVGLGLAICQAIVEVHGGEIYARNRPeGGASFHVLLP 881
Cdd:PRK11073 304 MVSG-REG---GTGLGLSIARNLIDQHSGKIEFTSWP-GHTEFSVYLP 346
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
785-881 |
1.62e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 50.28 E-value: 1.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 785 NLLENAAKYAGPRAQTGVRTSWRDDRLDLEVWDNGPGIPAGQEQAIFAKFARGNKESA--IPGVGLGLAICQAIVEVHGG 862
Cdd:cd16952 7 NLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCrnTGGTGLGLAIVKHVMSRHDA 86
|
90
....*....|....*....
gi 1755387238 863 EIYARNRPEGGASFHVLLP 881
Cdd:cd16952 87 RLLIASELGKGSRFTCLFP 105
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
779-881 |
1.62e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 47.76 E-value: 1.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 779 FERVLINLLENA--AKYAGPRAQTGVRTSWRDDRLD-------------LEVWDNGPGIPAGQEQAIFAKFARgNKESAi 843
Cdd:cd16919 1 LELAILNLAVNArdAMPEGGRLTIETSNQRVDADYAlnyrdlipgnyvcLEVSDTGSGMPAEVLRRAFEPFFT-TKEVG- 78
|
90 100 110
....*....|....*....|....*....|....*...
gi 1755387238 844 PGVGLGLAICQAIVEVHGGEIYARNRPEGGASFHVLLP 881
Cdd:cd16919 79 KGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
649-885 |
4.17e-06 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 49.23 E-value: 4.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 649 ESEEQARLASEREQLRnslLAALSHDlrTPLTVLFGqaeiLTLDLAAEGSNHAPQASEIRQHVLNTTRLVNNLLDMARIQ 728
Cdd:COG4585 41 ELAARAEEAREEERRR---IARELHD--GVGQSLSA----IKLQLEAARRLLDADPEAAREELEEIRELAREALAELRRL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 729 SGgfNLRKEWLTVEEVVGSALKMLEPGLGGRHIDLSLSDPLTLIHVDGPL---FERVLINLLENAAKYAGPRAQTgVRTS 805
Cdd:COG4585 112 VR--GLRPPALDDLGLAAALEELAERLLRAAGIRVELDVDGDPDRLPPEVelaLYRIVQEALTNALKHAGATRVT-VTLE 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 806 WRDDRLDLEVWDNGPGIPAGqeqaifakfargnkesAIPGVGLGLAICQAIVEVHGGEIYARNRPEGGASFHVLLPKETP 885
Cdd:COG4585 189 VDDGELTLTVRDDGVGFDPE----------------AAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLAAA 252
|
|
| UspA |
COG0589 |
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms]; |
253-372 |
8.47e-06 |
|
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
Pssm-ID: 440354 Cd Length: 136 Bit Score: 46.07 E-value: 8.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 253 ILLCIGQGAGNEKLVRTAARLAARLGSVWHAVYVETPR----------LHQLPETSRRAILSALHLAQELG--AETATLA 320
Cdd:COG0589 5 ILVPTDGSEEAERALEYAAELAKALGAELHLLHVVDPPpsaaagpeelEEELREEAEEALEEAAERLEEAGveVETVVRE 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1755387238 321 DPVEEkAVLRYAREHNLGKIVIGRRNKRRWwsQDTF----AERLARHAPdLDLLIV 372
Cdd:COG0589 85 GDPAE-AILEAAEELDADLIVMGSRGRSGL--RRLLlgsvAERVLRHAP-CPVLVV 136
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
360-883 |
8.87e-06 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 49.13 E-value: 8.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 360 LARHAPDLDLLIVALDDKPTPATAKAADNRPFIEKWRVQLRGCAVAVALCALITLVAHQWLIAFDAANLVMVYLLGVVLV 439
Cdd:COG3920 1 LLLALLLLLLLALAALLLLAALLLLAAALLLALLALLLLALLLLALLLASALLALLALSAAALAAALAVALAAAVGAAAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 440 ALFYGRWPSVVATIINVVSFDLFFIAPRGTLAVSDVQYLLTFAVMLSVGLIIGNLTAGVRYQARIARYREQRTRHLYEMS 519
Cdd:COG3920 81 LLALLVLLLLLLLAAAALALALLLAALAGLLLLAALLLLRLVALLAALALLALLLLLLLLLAILALAELAVALAELAAAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 520 KALAVGRSARDIAATSQQFIASTFHARGLLLLPDEHGKLQAPQPLAEITPWDEAIARWSFDKGLPAGAGTDTLPGVPYQI 599
Cdd:COG3920 161 LLLAEELAALRLAAAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 600 LPLRTAGKTLGLVIVEPGNLRQLMIpeqqrlletfTLLVASALERLFLTESEEQARLASEREQLRNSLLAALSHDLRTPL 679
Cdd:COG3920 241 LERRRRARGLGRLLLLLLLLLLLLR----------ALLLLAAGIRLVITERKRAEEELEASLEEKELLLRELHHRVKNNL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 680 TVLfgqAEILTLDLAAEGSNHAPQASEirqhvlnttRLVNNLLDMARIQ---SGGFNLRKewLTVEEVVGSALKMLEPGL 756
Cdd:COG3920 311 QVV---SSLLRLQARRADDPEAREALE---------ESQNRIQALALVHellYQSEDWEG--VDLRDYLRELLEPLRDSY 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 757 GGRHIDLSLSDPLTLIHVD-----GplferVLIN-LLENAAKYAGPRAQTG-VRTSWR--DDRLDLEVWDNGPGIPAGqe 827
Cdd:COG3920 377 GGRGIRIELDGPDVELPADaavplG-----LILNeLVTNALKHAFLSGEGGrIRVSWRreDGRLRLTVSDNGVGLPED-- 449
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 1755387238 828 qaifAKFARGNkesaipgvGLGLAICQAIVEVHGGEIyaRNRPEGGASFHVLLPKE 883
Cdd:COG3920 450 ----VDPPARK--------GLGLRLIRALVRQLGGTL--ELDRPEGTRVRITFPLA 491
|
|
| Usp |
pfam00582 |
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ... |
253-372 |
1.43e-04 |
|
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.
Pssm-ID: 425765 [Multi-domain] Cd Length: 137 Bit Score: 42.78 E-value: 1.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 253 ILLCIGQGAGNEKLVRTAARLAARLGSVWHAVYV-----ETPRLHQLPETSRRAILSALHLAQELGAETATLADPVEEK- 326
Cdd:pfam00582 1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVidpppSGAASLADESAEEEELELELAEAEALAAAAAAEAGGVKVEv 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1755387238 327 ---------AVLRYAREHNLGKIVIGRRnKRRWWSQDTF---AERLARHAPdLDLLIV 372
Cdd:pfam00582 81 vvvvgdpaeEILEVAEEEDADLIVMGSR-GRSGLSRLLLgsvAEYVLRHAP-CPVLVV 136
|
|
| USP-like |
cd00293 |
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ... |
253-372 |
1.84e-04 |
|
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.
Pssm-ID: 467483 [Multi-domain] Cd Length: 135 Bit Score: 42.33 E-value: 1.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 253 ILLCIGQGAGNEKLVRTAARLAARLGSVWHAVYVETPRLHQLPETSRRAILSAL-----HLAQELGAETATLADPVEEK- 326
Cdd:cd00293 2 ILVAVDGSEESERALEWALELAKRPGAELTLLHVVDPPPSSSLSGGLEELADELkeeaeELLEEAKKLAEEAGVEVETIv 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1755387238 327 -------AVLRYAREHNLGKIVIGRRNKRRWWSQ--DTFAERLARHAPdLDLLIV 372
Cdd:cd00293 82 vegdpaeAILEEAKELGADLIVMGSRGRSGLKRLllGSVSEYVLRHAP-CPVLVV 135
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
786-884 |
2.80e-04 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 44.24 E-value: 2.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 786 LLENAAKYA-GPRAQTG---VRTSWRDDRLDLEVWDNGPGIPAGQEQAIFAKFARGNKESaipgvGLGLAICQAIVEVHG 861
Cdd:COG2972 344 LVENAIEHGiEPKEGGGtirISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSSKGEGR-----GIGLRNVRERLKLYY 418
|
90 100
....*....|....*....|....*.
gi 1755387238 862 GEIYA---RNRPEGGASFHVLLPKET 884
Cdd:COG2972 419 GEEYGleiESEPGEGTTVTIRIPLEE 444
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
781-881 |
2.86e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 40.61 E-value: 2.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 781 RVLINLLENAAKYAGPrAQTGVRTSWRDDRLDLEVWDNGPGIPAGQEQaifakfargnkesaiPGVGLGLAICQAIVEVH 860
Cdd:cd16917 3 RIVQEALTNALKHAGA-SRVRVTLSYTADELTLTVVDDGVGFDGPAPP---------------GGGGFGLLGMRERAELL 66
|
90 100
....*....|....*....|.
gi 1755387238 861 GGEIYARNRPEGGASFHVLLP 881
Cdd:cd16917 67 GGTLTIGSRPGGGTRVTARLP 87
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
786-872 |
7.02e-04 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 40.28 E-value: 7.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 786 LLENAAKYAGPRAQTG---VRTSWRDDRLDLEVWDNGPGIPAGQEQAIFAKFARGnkesaipgvGLGLAICQAIVEvhgg 862
Cdd:COG2172 42 AVTNAVRHAYGGDPDGpveVELELDPDGLEIEVRDEGPGFDPEDLPDPYSTLAEG---------GRGLFLIRRLMD---- 108
|
90
....*....|
gi 1755387238 863 EIYARNRPEG 872
Cdd:COG2172 109 EVEYESDPGG 118
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
786-872 |
2.67e-03 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 38.02 E-value: 2.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 786 LLENAAKYAGPRAQTG---VRTSWRDDRLDLEVWDNGPGipagqeqaiFAKFARGNKESAIPGVGLGLAICQAIVEvhgg 862
Cdd:cd16936 8 AVTNAVRHAYRHDGPGpvrLELDLDPDRLRVEVTDSGPG---------FDPLRPADPDAGLREGGRGLALIRALMD---- 74
|
90
....*....|
gi 1755387238 863 EIYARNRPEG 872
Cdd:cd16936 75 EVGYRRTPGG 84
|
|
| PRK15362 |
PRK15362 |
type III secretion system translocon protein; |
669-764 |
4.50e-03 |
|
type III secretion system translocon protein;
Pssm-ID: 237952 Cd Length: 473 Bit Score: 40.57 E-value: 4.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 669 AALSHDLRTPLTVLFGQAEILTLDLAAEGSNHAPQASEIRQHVLNTTRLVNN----------LLDMARIQSGG-FNLRKE 737
Cdd:PRK15362 78 LSLSDFEQTPMDVMSMMATLLILSVFGDNAQSLCQALEIATEVQEALRDKQVkeyqeqiqkaIEQEDKARKAGiFGAIFD 157
|
90 100
....*....|....*....|....*...
gi 1755387238 738 WLT-VEEVVGSALKMLEPGLGGRHIDLS 764
Cdd:PRK15362 158 WIVgIFETVIGALKVVEGFLSGNPAEMA 185
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
649-881 |
8.33e-03 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 39.65 E-value: 8.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 649 ESEEQARLASEREQLrNSLLAALSHDLRTPLTVLFGQAEILTLDLAAEGSN---HAPQASEIRQHVLNTTRLVNNLLDMA 725
Cdd:PRK13557 149 DAEDALRQAQKMEAL-GQLTGGIAHDFNNLLQVMSGYLDVIQAALSHPDADrgrMARSVENIRAAAERAATLTQQLLAFA 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 726 RIQsggfNLRKEWLTVEEVVGSALKMLEPGLGGR-HIDLSLSDPLTLIHVDGPLFERVLINLLENAAKYAGPRAQTGVRT 804
Cdd:PRK13557 228 RKQ----RLEGRVLNLNGLVSGMGELAERTLGDAvTIETDLAPDLWNCRIDPTQAEVALLNVLINARDAMPEGGRVTIRT 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755387238 805 SWRD-DRLDLE--------------VWDNGPGIPAGQEQAIFAKFARGNKESAipGVGLGLAICQAIVEVHGGEIYARNR 869
Cdd:PRK13557 304 RNVEiEDEDLAmyhglppgryvsiaVTDTGSGMPPEILARVMDPFFTTKEEGK--GTGLGLSMVYGFAKQSGGAVRIYSE 381
|
250
....*....|..
gi 1755387238 870 PEGGASFHVLLP 881
Cdd:PRK13557 382 VGEGTTVRLYFP 393
|
|
| |
