|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
1-435 |
4.64e-79 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 252.03 E-value: 4.64e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 1 MKTLIKLAVPLIISQLiAQMLI-FTDVWMMAKLSIVAIAGGGLGAAVYSFVFIIASSTVGCVANLIAIAYGKqlrqpeKG 79
Cdd:cd13131 2 LRALLRLALPILIAQL-AQMAMgFVDTVMAGRLGADDLAAVALGSSLWFPVFTFGMGLLLAVTPLVAQAHGA------GD 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 80 EHDVRLALKGGILLAVLLTLSLQPLFYLMKGWLLKAGQDPEAVDLAITYLHAMKWSMLPTLILLVLRSLVSAFSETRSIM 159
Cdd:cd13131 75 RRRIRRAVRQGLWLALLLSLPLMLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAM 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 160 VMSLITVILNVPLSYLLAFTL----KMGIAGLGYGTSLAAFIVMIGYGYWVFSRPKYRRYMPFRDFHEYRLGIMKPLMVL 235
Cdd:cd13131 155 VITLLALVLNIPLNYVLIFGKfglpALGGAGAGLATAIVYWLMFLALAFYIRRHKRFRRYRLFARFWRPDWARLKELLRL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 236 GIPIMIATMLEHALFSGAALLAGTLGAVSLAIHQIAMQCLNFSWNLAFGLSQAASILVSQHFGKDEPDMVRQYAKLGLGL 315
Cdd:cd13131 235 GLPIGLTIFFEVSLFAAVALLMGRLGTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGLGL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 316 VTATSAVIGILLSIWPEFLTHVFSieGDALAEQLVAQLpgvMIMVALCFVVDAWQLSAISILRGMKVVVGPTISTVIGYW 395
Cdd:cd13131 315 GVGFAALTALLLLLFPEQIAGLYT--NDPAVIALAASL---LVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLALISYW 389
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 1755589622 396 FVGLPAAYLLMKWAGLE--GIWGGLAIGLAATGVMLVVLLFK 435
Cdd:cd13131 390 GIGLPLGYLLAFTTGLGafGVWIGLIIGLALAAILLLWRFRR 431
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
1-432 |
1.62e-67 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 221.56 E-value: 1.62e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 1 MKTLIKLAVPLIISQLIAQMLIFTDVWMMAKLSIVAIAGGGLGAAVYSFVFIIASSTVGCVANLIAIAYGkqlrqpEKGE 80
Cdd:COG0534 7 LKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALG------AGDR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 81 HDVRLALKGGILLAVLLTLSLQPLFYLMKGWLLKA-GQDPEAVDLAITYLHAMKWSMLPTLILLVLRSLVSAFSETRSIM 159
Cdd:COG0534 81 EEARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLlGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 160 VMSLITVILNVPLSYLLAFTLKMGIAGLGYGTSLAAFIVMIGYGYWVFSRPKYRRYMPFRdfHEYRLGIMKPLMVLGIPI 239
Cdd:COG0534 161 IIMLIGNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRD--LRPDRKILKRILRIGLPA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 240 MIATMLEHALFSGAALLAGTLGAVSLAIHQIAMQCLNFSWNLAFGLSQAASILVSQHFGKDEPDMVRQYAKLGLGLVTAT 319
Cdd:COG0534 239 GLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGI 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 320 SAVIGILLSIWPEFLTHVFSIEGDALAeqLVAQLpgvMIMVALCFVVDAWQLSAISILRGMKVVVGPTISTVIGYWFVGL 399
Cdd:COG0534 319 GLLLALLLFLFPEPIIGLFTDDPEVIA--LAATY---LRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRL 393
|
410 420 430
....*....|....*....|....*....|....
gi 1755589622 400 PAAYLLMKWA-GLEGIWGGLAIGLAATGVMLVVL 432
Cdd:COG0534 394 PLAYLLAFLGlGLTGVWLALPIGEVLRALLLLLR 427
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
1-430 |
8.55e-50 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 176.09 E-value: 8.55e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 1 MKTLIKLAVPLIISQLIAQMLIFTDVWMMAKLSIVAIAGGGLGAAVYSFVFIIASSTVGCVANLIAIAYGKqlRQPEkge 80
Cdd:PRK00187 9 LKAILRLAGPLIASQLAHMLMVFTDTLMMGRLGPEALAGGGLGAASYSFVSIFCVGVIAAVGTLVAIRHGA--GDIE--- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 81 hDVRLALKGGILLAVLLTLSLQPLFYLMKGWLLKAGQDPEAVDLAITYLHAMKWSMLPTLILLVLRSLVSAFSETRSIMV 160
Cdd:PRK00187 84 -GATRLAQAGLWLAWLLALVAALLLWNLKPLLLLFGQAPQNVDAAMQFLHLLPFALPGYLSFMALRGFTSALGRAGPVMV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 161 MSLITVILNVPLSYLLA---FTL-KMGIAGLGYGTSLAAFIVMIGYGYWVFSRPKYRRYMPFRDFHEYRLGIMKPLMVLG 236
Cdd:PRK00187 163 ISLAGAVANLLLNYALIegwFGLpKLGLMGIGLVTALVSNGMALALALYIRRHPAYAAYPLRKGLSRPSRAALRELWRLG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 237 IPIMIATMLEHALFSGAALLAGTLGAVSLAIHQIAMQCLNFSWNLAFGLSQAASILVSQHFGKDEPDMVRQYAKLGLGLV 316
Cdd:PRK00187 243 LPIGGTYAVEVGLFTFAALCMGALGSTQLAAHQIALQIVSVAFMVPVGLSYAVTMRVGQHYGAGRLLEARRAGRVGIGFG 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 317 TATSAVIGILLSIWPEFLTHVFsIEGDALAEQLVAQLPGVMIMVALCF-VVDAWQLSAISILRGMKVVVGPTISTVIGYW 395
Cdd:PRK00187 323 AVVMLLFAGLFWLLPEAIIGLF-LDRNDPAFAEIVQLAVSLLAVAAWFeLFDGTQTIAMGAIRGLKDARTTFLIGLACYW 401
|
410 420 430
....*....|....*....|....*....|....*..
gi 1755589622 396 FVGLPAAYLLMKWAGL--EGIWGGLAIGLAATGVMLV 430
Cdd:PRK00187 402 LVGAPLAWLLAFTLGWgaVGVWWGLALGLACAAVALT 438
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
2-435 |
4.81e-48 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 170.40 E-value: 4.81e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 2 KTLIKLAVPLIISQLIAQMLIFTDVWMMAKLSIVAIAGGGLGAAVYSFVFIIASSTVGCVANLIAIAYGkqlrqpEKGEH 81
Cdd:cd13133 5 REILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPAGVLYFAILMLFFGLSSGVQVFVAQYNG------AGRYS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 82 DVRLALKGGILLAVLLTLSLQPLFYLMKGWLL-KAGQDPEAVDLAITYLHAMKWSMLPTLILLVLRSLVSAFSETRSIMV 160
Cdd:cd13133 79 RIGRVLWQGLYFSLLLAPLLALLSALAAPLLFlLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 161 MSLITVILNVPLSYLLAF----TLKMGIAGLGYGTSLAAFIVMIGYgYWVFSRPKYRRYMPFRDFHEYRLGIMKPLMVLG 236
Cdd:cd13133 159 ANLVMVVVNIVLDYALIFgklgFPAMGIAGAAIATVIAEAVSLLFF-LLLLFRRKNRRRFGLRRAWRFDRELLRRILRLG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 237 IPIMIATMLEHALFSGAALLAGTLGAVSLAIHQIAMQCLNFSWNLAFGLSQAASILVSQHFGKDEPDMVRQYAKLGLGLV 316
Cdd:cd13133 238 LPSGLQFFLDVGAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLA 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 317 TATSAVIGILLSIWPEFLTHVFSIEGDalAEQLVAQLPGVMIMVALCFVVDAWQLSAISILRGMKVVVGPTISTVIGYWF 396
Cdd:cd13133 318 LAYMLLLGILFLLFPELLLSIFTPGAD--FALIAELAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAELIVAWL 395
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 1755589622 397 VGLPAAYLLMKW-AGLEGIWGGLAIGLAATGVMLVVLLFK 435
Cdd:cd13133 396 YLLPPAYLLVVLgAGLAGAWTVETVYVIVLALIFLLRFRS 435
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
2-435 |
2.06e-44 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 161.13 E-value: 2.06e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 2 KTLIKLAVPLIISQlIAQMLI-FTDVWMMAKLSIVAIAGGGLGAAVYSFVFIIASSTVGCVANLIAIAYG--KQLRQPEK 78
Cdd:PRK01766 12 RQLLALALPILLAQ-VAQTAMgFVDTVMAGGVSATDLAAVAIGTSIWLPVILFGHGLLLALTPIVAQLNGagRRERIAHQ 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 79 GEHDVRLALKGGILLAVLLTLSLQPLFYLMkgwllkaGQDPEAVDLAITYLHAMKWSMLPTLILLVLRSLVSAFSETRSI 158
Cdd:PRK01766 91 VRQGLWLALFLSVLIMLVLYNAVPPILNMM-------NLEPEVADIAVGYLHALLWGIPAYLLYQVLRSFIDGLGKTKPT 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 159 MVMSLITVILNVPLSYLLAFTL----KMGIAGLGYGTSLAAFIVMIGYGYWVFSRPKYRRYMPFRDFHEYRLGIMKPLMV 234
Cdd:PRK01766 164 MVIGFLGLLINIPLNYIFIYGKfgfpELGGVGCGVATAIVYWVMFLAMLIYIKRARRFRDFRLFKGLYKPDWAVIKRLLK 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 235 LGIPIMIATMLEHALFSGAALLAGTLGAVSLAIHQIAMqclNFSwNLAF----GLSQAASILVSQHFGKDEPDMVRQYAK 310
Cdd:PRK01766 244 LGLPIGLAIFFEVSLFAVVTLLVSPLGTVTVAAHQIAL---NFS-SLLFmlplSLAMALTIRVGFELGAGRTLDARQYAY 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 311 LGLGLVTATSAVIGILLSIWPEFLTHVFSIEGD--ALAEQLvaqlpgvMIMVALCFVVDAWQLSAISILRGMKVVVGPTI 388
Cdd:PRK01766 320 IGLAVGLGMALLTAIFLVLFREQIALLYTDDPEvvALASHL-------LLFAALFQFSDAIQVIGSGALRGYKDTRVIFF 392
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 1755589622 389 STVIGYWFVGLPAAYLLMKWAGL--EGIWGGLAIGLAATGVMLVVLLFK 435
Cdd:PRK01766 393 ITFIAYWVLGLPLGYILALTDPMgpFGFWIGLIIGLTAAAILLLLRLRK 441
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
1-435 |
4.13e-39 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 146.18 E-value: 4.13e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 1 MKTLIKLAVPLIISQLIAQMLIFTDVWMMAK-----LSIVAIAGGGLGAAVYSFVFIIASStvgcVANLIAIAYGkqLRQ 75
Cdd:cd13132 2 AKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHlgkleLAAASLASSFANVTGFSILLGLASA----LDTLCGQAFG--AKN 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 76 PEKgehdVRLALKGGILLAVLLTLSLQPLFYLMKGWLLKAGQDPEAVDLAITYLHAMKWSMLPTLILLVLRSLVSAFSET 155
Cdd:cd13132 76 YKL----VGVYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIV 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 156 RSIMVMSLITVILNVPLSYLLAFTLKMGIAGLGYGTSLAAFIVMIGYGYWVFSRPKYRRYmpFRDFHEYRLGIMKPLMVL 235
Cdd:cd13132 152 LPLVYISLVALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKAT--WGGFSREAFRGWGPFLKL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 236 GIPIMIATMLEHALFSGAALLAGTL-GAVSLAIHQIAMQCLNFSWNLAFGLSQAASILVSQHFGKDEPDMVRQYAKLGLG 314
Cdd:cd13132 230 AIPSALMLCLEWWAFEILVLLAGLLpGTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALI 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 315 LVTATSAVIGILLSIWPEFLTHVFSieGDALAEQLVAQLpgvMIMVALCFVVDAWQLSAISILRGMKVVVGPTISTVIGY 394
Cdd:cd13132 310 LSLVIGVVVAILLLVLRDVWAYLFT--SDEEVIALVADL---LPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAY 384
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 1755589622 395 WFVGLPAAYLLMKWA--GLEGIWGGLAIGLAATGVMLVVLLFK 435
Cdd:cd13132 385 YLIGLPVGLLLAFVLglGLKGLWIGLIAGLILQAVILLLIILR 427
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
2-435 |
1.59e-38 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 144.58 E-value: 1.59e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 2 KTLIKLAVPLIISQLIAQMLIFTDVWMMAKLSIVAIAGGGLGAAVYSFVFIIASS-TVGCVAnLIAIAYGKQLRqpekge 80
Cdd:cd13137 1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLLLVLNMAlGTGTVA-LVSQSYGAGDY------ 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 81 HDVRLALKGGILLAVLLTLSLQPLFYLMKGWLLKA-GQDPEAVDLAITYLHAMKWSMLPTLILLVLRSLVSAFSETRSIM 159
Cdd:cd13137 74 ERARRALGQSLLLALLLSLPLALLGLLFAEPLLRLlGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPM 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 160 VMSLITVILNVPLSYLLAFTL----KMGIAGLGYGTSLAAFIVMIGYGYWVFSRPKYRRymPFRDFHEYRLGIMKPLMVL 235
Cdd:cd13137 154 YIMIIVNVLNIVLDYVLIFGLwgfpGLGVAGAALATVISRVVGALLLLFLLLRGRLPIK--ISFKGFRLDRKIIKKLLRI 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 236 GIPimiaTMLEHALFSGAALL----AGTLGAVSLAIHQIAMQCLNFSWNLAFGLSQAASILVSQHFGKDEPDMVRQYAKL 311
Cdd:cd13137 232 GLP----AGLEQLLRSLGFLVllaiVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKR 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 312 GLGLVTATSAVIGILLSIWPEFLTHVFSIEGDALAEqlvaqlpGVMIMVALCFVVDAWQLSAI--SILRGMKVVVGPTIS 389
Cdd:cd13137 308 ALRLGVLFMGLLGLLLFIFAPPLASLFTPDPEVIEL-------GVLYLRIVALSQPFLAISFVlsGALRGAGDTRPPLII 380
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 1755589622 390 TVIGYWFVGLPAAYLLMK--WAGLEGIWGGLAIGLAATGVMLVVLLFK 435
Cdd:cd13137 381 NLISMWLVRLPLAYLLGFvlGLGLTGIWLAMFVDTIVRAILLLYRFRK 428
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
10-339 |
2.03e-35 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 134.29 E-value: 2.03e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 10 PLIISQLIAQMLIFTDVWMMAKLSIV----AIAGGGLGAAVYSFVFIIASSTVGCVANliAIAYGKQLRQPEKGEHDVRL 85
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVdlaaVSLGSSVFMFLFSILMGLGTATTALVAQ--AVGAGNYQRLGRQAQQSLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 86 ALKGGILLAVLLTLSLQPLFYLMkgwllkaGQDPEAVDLAITYLHAMKWSMLPTLILLVLRSLVSAFSETRSIMVMSLIT 165
Cdd:TIGR00797 79 ALLLGLPVLLVGYFFIDPLLSLM-------GADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIG 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 166 VILNVPLSYLLAFTL--KMGIAGLGYGTSLAAFIVMIGYGYWVFSRPKYRRYMPFrdFHEYRLGIMKPLMVLGIPIMIAT 243
Cdd:TIGR00797 152 NVINIILNYILIFGKfgFLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEG--LLKPDWEVLKRLLKLGLPIAFRV 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 244 MLEHALFSGAALLAGTLGAVSLAIHQIAMQCLNFSWNLAFGLSQAASILVSQHFGKDEPDMVRQYAKLGLGLVTATSAVI 323
Cdd:TIGR00797 230 ILESLSFALLALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVL 309
|
330
....*....|....*.
gi 1755589622 324 GILLSIWPEFLTHVFS 339
Cdd:TIGR00797 310 AIILILFREFIARLFT 325
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
8-434 |
1.10e-33 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 130.91 E-value: 1.10e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 8 AVPLIISQLIAQMLIFTDVWMMAKLSIVAIAGGGLGAAVYSFVFIIASSTVGCVANLIAIAYGKQLRQpekgehDVRLAL 87
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEE------KARRVL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 88 KGGILLAVLLTLSLQPLFYLMKGWLLKAGQDPEAV-DLAITYLHAMKWSMLPTLILLVLRSLVSAFSETRSIMVMSLITV 166
Cdd:cd12082 75 VQSIVLAILLGLLLAALLLFFSPLILSLLGAEEEViELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSN 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 167 ILNVPLSYLLAFTL---KMGIAGLGYGTSLAAFIVMIGYGYWVFSRpkYRRYMPFRDFHEYRLGIMKPLMVLGIPIMIAT 243
Cdd:cd12082 155 LLNILLDPLLIFGLgppELGIAGAALATVISYVIGALLLLIYLRKG--KKILKFKLSLLKPDLELLRRLLRIGLPSAIQN 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 244 -MLEHALFSGAALLAGTLGAVSLAIHQIAMQCLNFSWNLAFGLSQAASILVSQHFGKDEPDMVRQYAKLGLGLVTATSAV 322
Cdd:cd12082 233 sLLSLGLLIIVAIVAAFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 323 IGILLSIWPEFLTHVFSIEGDALAEQLVaqlpgVMIMVALCFVVDAWQLSAISILRGMKVVVGPTISTVIGYWFVGLPAA 402
Cdd:cd12082 313 LGLLILLFPEPILSLFTNDPEFLELAVS-----YLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLA 387
|
410 420 430
....*....|....*....|....*....|...
gi 1755589622 403 YLLMKWA-GLEGIWGGLAIGLAATGVMLVVLLF 434
Cdd:cd12082 388 YVLAYLGlGLYGIWLALVISLILAALVLLLFFR 420
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
2-420 |
2.24e-31 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 124.92 E-value: 2.24e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 2 KTLIKLAVPLIISQLIAQMLIFTDVWMMAKLSIVAIAGGGLGAAVYSFVFIIASSTVGCVANLIAIAYGKqlRQPEKGEH 81
Cdd:cd13134 3 LSLFALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILFLLILIFSFISTGTSILIAQYLGA--KDKKKARQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 82 DVRLALKGGILLAVLLTLSlqpLFYLMKGWLLKAGQDPEAVDLAITYLHAMKWSMLPTLILLVLRSLVSAFSETRSIMVM 161
Cdd:cd13134 81 IAGVALLFNLLLGLVFSLL---LLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 162 SLITVILNVPLSYLLAFTL----KMGIAGLGYGTSLAAFIVMIGYGYWVFSRPKYRryMPFRDFHEYRLGIMKPLMVLGI 237
Cdd:cd13134 158 SLIMNILNIVGNYLLIFGWfglpKLGVAGVAISTVISRAVGLVLLFILLFRKLKIR--FRLKDLRPFPKKLLKKILKIGL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 238 PimiaTMLEHALFSGAALLA----GTLGAVSLAIHQIAMQCLNFSWNLAFGLSQAASILVSQHFGKDEPDMVRQYAKLGL 313
Cdd:cd13134 236 P----SAGEELSYNLSQTVItafiARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSL 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 314 GLVTATSAVIGILLSIWPEFLTHVFSIEGDALAeqLVAQLpgVMIMVALCFvVDAWQLSAISILRGMKVVVGPTISTVIG 393
Cdd:cd13134 312 KIGLLVSLAVALLLALFREPILGLFTDDPEIIA--LGKTL--LLISILLEP-GRAFNIVLIGSLRAAGDARFPVLIGIIS 386
|
410 420 430
....*....|....*....|....*....|
gi 1755589622 394 YWFVGLPAAYLL---MKWaGLEGIWGGLAI 420
Cdd:cd13134 387 MWGISVPLAYLLgivLGL-GLLGVWIAFAA 415
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
1-436 |
1.29e-29 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 119.87 E-value: 1.29e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 1 MKTLIKLAVPLIISQLIAQMLIFTDVWMMAKL--SIVAIAGGGLGAAVYSFVFIIASSTVGCVAnLIAIAYGkqlrqpEK 78
Cdd:cd13138 2 LKTLLLFALPLLLSNLLQQLYNLVDLLIVGQFlgVAALAAVSNGSPIIFLLTAIGMGLSMGGTI-LISQYIG------AK 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 79 GEHDVRLALKGGILLAVLLTLSLQPLFYLMKGWLLKAGQDP-EAVDLAITYLHAMKWSMLPTLILLVLRSLVSAFSETRS 157
Cdd:cd13138 75 DEEKAKKAVGTLLVLFLILGIVLTILGLLFAPPILRLMNTPaEILELAVSYLRICFLGIPFIFGYNAYSAILRGLGDSKT 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 158 IMVMSLITVILNVPLSYLLAFTLKMGIAGLGYGTSLAAFIVMIgYGYWVFSRPKYRRYMPFRDFHeYRLGIMKPLMVLGI 237
Cdd:cd13138 155 PLYFVIIACVLNIILDLLFIAVFHMGVAGAALATVIAQAISVL-LALYYLRKKKLPFKLSLKDFR-FDKEILKEILKIGL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 238 PImiatMLEHALFSGAALL----AGTLGAVSLAIHQIAMQCLNFSWNLAFGLSQAASILVSQHFGKDEPDMVRQYAKLGL 313
Cdd:cd13138 233 PS----ALQQSLVSISFLIinsiVNSYGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGI 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 314 GLVTATSAVIGILLSIWPEFLTHVFSIEGDALAEqlvaqlpGVMIM--VALCFVVDAWQLSAISILRGMKVVVGPTISTV 391
Cdd:cd13138 309 IISLIIGLIIILLVFFFAPQLLGLFTSDPEVIEI-------GAEYLriYSIDYILFGILFVFNGLFRGLGKTKFPMIISI 381
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 1755589622 392 IGYWFVGLPAAYLLMKWA--GLEGIWGGLAIGLAATGVMLVVLLFKN 436
Cdd:cd13138 382 LRLWLVRIPLAYLLSRLTglGLFGIWLAMPISNILSAIICIIYYRKG 428
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
107-435 |
1.25e-25 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 108.42 E-value: 1.25e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 107 LMKGWLLKAGQDPEAVDLAITYLHAMKWSMLPTLILLVLRSLVSAFSETRSIMVMSLITVILNVPLSYLLAFTLKMGIAG 186
Cdd:cd13136 104 LLALALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLILQIVGNVVNIVLDPLFVFGLGWGVAG 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 187 LGYGTsLAAFIVMIGYGYWVFSRpKYRRYMPFRDFHEYRLGIMKPLMVLGIPIMIATMLEHALFSGAALLAGTLGAVSLA 266
Cdd:cd13136 184 AALAT-VIAQYLGALLGLWLLRR-RVRLLGKSLSRRLPSKAALKRLFKLNRDIFIRTLALLAAFLFFTALAARLGDVILA 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 267 IHQIAMQCLNFSWNLAFGLSQAASILVSQHFGKDEPDMVRQYAKLGLGLVTATSAVIGILLSIWPEFLTHVFSIEgdala 346
Cdd:cd13136 262 ANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQWGLGLGVLLALLFFLGGEPIIRLFTDD----- 336
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 347 EQLVAQLPGVMIMVALCFVVDAWQLSAISILRGMKVVVGPTISTVIGYwFVGLPAAYLLMKWAGLEGIWGGLAIGLAATG 426
Cdd:cd13136 337 PAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRYLRNSMLVSL-AVFLPLLFLLVPLWGNHGLWLALILFMLLRG 415
|
....*....
gi 1755589622 427 VMLVVLLFK 435
Cdd:cd13136 416 LTLALRLPR 424
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
2-435 |
1.03e-22 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 99.91 E-value: 1.03e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 2 KTLIKLAVPLIISQLIaQMLI-FTDVWMMAKLSIVAIAGGGLGaavySFVFIIASSTVGCVAN----LIAIAYGKQLRQP 76
Cdd:cd13140 5 KTLLRLALPIMGTSFI-QMAYnLTDMFWVGRLGSDAVAAVGTA----GFFVWLAYALALLSKIgaqvKVSQSIGAKDEKE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 77 EKG--EHDVRLALKGGILLAVLLTLSLQPLFYLMKGwllkagQDPEAVDLAITYLHAMKWSMLPTLILLVLRSLVSAFSE 154
Cdd:cd13140 80 ARKyaRNALQLNLLLGILYGLLLLLFAKPLIGFFNL------GDAEVISLAITYLRIVALGLIFSFLNPVFTGIFNALGD 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 155 TRSIMVMSLITVILNVPLSYLLAFTL----KMGIAGLGYGTSLAAFIVMIGYGYWVFSRPKYRRYMPFRDFheYRLGIMK 230
Cdd:cd13140 154 SKTPFIINAIGLVLNIILDPLLIFGFgpfpALGVAGAALATVLAQAIVFLLFLYALKKKKGLFLKIRILKR--PDRKYIK 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 231 PLMVLGIPIMIATMLeHALFS-GAALLAGTLGAVSLAIHQIAMQCLNFSWNLAFGLSQAASILVSQHFGKDEPDMVRQYA 309
Cdd:cd13140 232 EILKLGLPVALQSIL-FALISmILARIIASFGPVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGY 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 310 KLGLGLVTATSAVIGILLSIWPEFLTHVFSIEGDALAEqlvaqlpGVMIMVALCF--VVDAWQLSAISILRGMKVVVGPT 387
Cdd:cd13140 311 KTALKIASAIGLFATLLLFFFGEPLFSLFIPDPETIAI-------GVDYLRILGFsqLFMCLEITTTGAFNGLGRTKPPA 383
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 1755589622 388 ISTVIgywFVGL--PAAYLLMKWA-GLEGIWGGLAIGLAATGVMLVVLLFK 435
Cdd:cd13140 384 IISIV---FNGLriPLALLLSPTGlGLNGIWWAISISSILKGIILTIWFLL 431
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
1-435 |
1.31e-21 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 96.88 E-value: 1.31e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 1 MKTLIKLAVPLIISQLIAQMLIFTDVWMMAKLSivaIAGGGLGAAVYSFVFIIASSTVG-CVANLIAIAYGKQLRQPEKG 79
Cdd:cd13142 10 LRTLLKLAWPIIVSNLLQVAYNLADTFWLGRLG---ADAVAAPSISWPLIFLFISLGGGlTVAGTALVAQYTGAGDYDKA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 80 EHD----VRLALKGGILLAVLLTLSLQPLFylmkgwLLKAGQDPEAVDLAITYLHAMKWSMLPTLILLVLRSLVSAFSET 155
Cdd:cd13142 87 NKVagqtFSFVIILSLILAVLGYILSRPLL------LLLIGAPEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIGDT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 156 RSIMVMSLITVILNVPLSYLLAFTL----KMGIAGLGYGTSLAAFIVMIgYGYWVFSRPKYRRYMPFRDFhEYRLGIMKP 231
Cdd:cd13142 161 KTPMKIMFGSVLLNVILDPLLIFGIgpfpGLGVAGAALATVISRGIAAV-IGLYLLFKGRVGLKISLRDL-KPDWEWLKK 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 232 LMVLGIPIMIAtMLEHAL-FSGAALLAGTLGAVSLAIHQIAMQCLNFSWNLAFGLSQAASILVSQHFGKDEPDMVRQYAK 310
Cdd:cd13142 239 IFRIGLPSSIE-QSARALgFTVMTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVK 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 311 LGLGLVTATSAVIGILLSIWPEFLTHVFSIEGDALAEqlvaqlpGV--MIMVALCFVVDAWQLSAISILRGMKVVVGPTI 388
Cdd:cd13142 318 KAALLIFLILVIGGVLAFLFAEPIVRVFINDPEVIKE-------GAdfLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMI 390
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 1755589622 389 STVIGYWFVGLPAAYLLMKWAGL--EGIWGGLAIGLAATGVMLVVLLFK 435
Cdd:cd13142 391 ISILRLWVIRIPLAYLLAYVLGLgvTGIWIAMAISNIVAALIALAWFKR 439
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
115-434 |
8.41e-20 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 91.03 E-value: 8.41e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 115 AGQDPEAVDLAITYLHAMKWSMLPTLILLVLRSLVSAFSETRSIMVMSLITVILNVPLSYLLAFTLKMGIAGLGYGTSLA 194
Cdd:cd13143 113 LGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGMLIGAVLNIILDPLFIFVLGLGIAGAALATVIA 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 195 AFIVMIGYGYWVFSRPKYRRymPFRDFHEYRLGIMKPLMVLGIPIMIATMLEHAL-FSGAALLAGTLGAVSLAIHQIAMQ 273
Cdd:cd13143 193 QLISLLLLLLYFFRGKSLLK--LSLLRFKLSLKIIKEILALGFPSFLMQLSSSVVtIVLNLTLLGYGGDIGVAAFGIVTR 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 274 CLNFSWNLAFGLSQAASILVSQHFGKDEPDMVRQYAKLGLGLVTATSAVIGILLSIWPEFLTHVFSieGDALAEQLVAQl 353
Cdd:cd13143 271 ILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIYGLVLFLILLLFPEQIVSLFT--DDPELIALAAR- 347
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 354 pgVMIMVALCFVVDAWQLSAISILRGM-KVVVGPTISTVIGYWFVgLPAAYLLMKWAGLEGIWGGLAIGLAATGVMLVVL 432
Cdd:cd13143 348 --ILRIFLLAFPLAGINIVLSGYFQAIgKAKRAALLSLLRQGLFL-IPLLLILPRLFGLDGIWLAFPLAEILTLLLALIL 424
|
..
gi 1755589622 433 LF 434
Cdd:cd13143 425 LK 426
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
111-436 |
1.45e-13 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 72.26 E-value: 1.45e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 111 WLLKAGQDPEAVDLAITYLHAMKWS----MLPTLILLVLRSLVSAFSETRSIMVMSLITVILNVPLSYLLAFTLKMGIAG 186
Cdd:cd13139 118 ILSLMGASPAVIAEGYGYTRIMFGGngfiMLLFLINGIFRGAGDAAIAMRSLWLANGLNIILDPLFIFGLGPIPAMGVTG 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 187 LGYGTSLAAFIVMIgYGYWVFSRPKYRRYMPFRDFhEYRLGIMKPLMVLGIPIMIATMLEHALFSGAALLAGTLGAVSLA 266
Cdd:cd13139 198 AAIATTIGRSIGVL-YQLYHLFKGKGRIQIRRRHL-KLDWAIIKKIIKIAVGGILQFLIASSSWIFLVRIIAEFGSTALA 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 267 IHQIAMQCLNFSWNLAFGLSQAASILVSQHFGKDEPDMVRQYAKLGLGLVTATSAVIGILLSIWPEFLTHVFSIEgdala 346
Cdd:cd13139 276 GYTIAIRIIMFALLPAWGLSNAAATLVGQNLGAGQPDRAEKSVWRAGKYNMVFLGIVSLVFFLFAEPLVSFFTTD----- 350
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 347 EQLVAQLPGVMIMVALCFVVDAWQLSAISILRGMKVVVGPTISTVIGYWFVGLPAAYLLMKWAGLE--GIWGGLAIGLAA 424
Cdd:cd13139 351 PEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTLINLVGFWLFQIPLAYLLARHLNLGpkGVFIAIPIAETV 430
|
330
....*....|..
gi 1755589622 425 TGVMLVVLLFKN 436
Cdd:cd13139 431 LAIAAIILFRRG 442
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
2-435 |
1.56e-13 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 72.26 E-value: 1.56e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 2 KTLIKLAVPLIISQLIAQMLIFTDVWMMAKLSIVAIAGGGLGAAVYSFVFIIASSTVGCVANLIAIAYG--KQLRQPEKG 79
Cdd:cd13144 8 RLLLTMSIPAMISMLFQALYNIVDSIFVARLGENALTAVSLAFPIQNLMIAVAVGTGVGVNALLSRSLGekDQKEANKAA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 80 EHDVRLALKGGILLAVLLTLSLQPLFYLMkgwllkaGQDPEAVDLAITYLHAMKWSMLPTLILLVLRSLVSAFSETRSIM 159
Cdd:cd13144 88 NNGLLLALLSYLLFLLLGLFGVKPFFRLF-------TDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 160 VMSLITVILNVPLSYLLAFTL----KMGIAGLGYGTSLAAFIVMIgYGYWVFSRPKYRRYMPFRDFHEyRLGIMKPLMVL 235
Cdd:cd13144 161 IAQLIGAIINIILDPILIFGLfgfpAMGIAGAAIATVIGQILAMF-LAFFFLLRKNKDVQPDLRLFRP-SLRIIKEIYAV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 236 GIPIMIATMLEHALFSGAALLAGTLGAVSLAIHQIAMQCLNFSWNLAFGLSQAASILVSQHFGKDEPDMVRQYAKLGLGL 315
Cdd:cd13144 239 GLPSIIMQAISSVMVFGLNKILAGFGPTAVAVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIREAIKYAILI 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 316 VTATSAVIGILLSIWPEFLTHVFSIEGDALAEQLVAqlpgvMIMVALCFVVDAWQLSAISILRGMKVVVGPTISTVIGYW 395
Cdd:cd13144 319 AVVIMLAGGLLFQLFPDQLLGLFNASEEMLAIGVPA-----LRIISLSFLFAALSIILSGLFQALGRGVYSLIISVARQL 393
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 1755589622 396 FVGLPAAYLLMKWAGLEGIWGGLAIGLAATGVMLVVLLFK 435
Cdd:cd13144 394 VVLLPLAWLLAKMFGLNGVWWSFPIAEIVSFLLSLLFLKR 433
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
2-339 |
2.38e-12 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 68.47 E-value: 2.38e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 2 KTLIKLAVPLIISQLIAQMLIFTDVWMMAKLSIVAIAGGGLGAAvySFVFIIASSTVGCVANLIAIAYGKQLRQPEKGEH 81
Cdd:cd13135 1 KKINHIAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVTT--PFNTITGFLGSISIGFTILGSQSVGAKDIKRIND 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 82 DVRLALKG----GILLAVLLTLSLQPLFYLMkgwllkaGQDPEAVDLAITYLHAMKWSMLPTLILLVLRSLVSAFSETRS 157
Cdd:cd13135 79 YAISSIVYnsiiGVILFLLWLFGARIIFVLF-------GVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKP 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 158 IMVMSLITVILNVPLSYLLAFTL----KMGIAGLGYGTSLAAFIVMIGYGYWVFSRPKYRRYMPFRDFHEYRLGIMKPLM 233
Cdd:cd13135 152 IMYGGIIKNLLNVILDYVLIFGNfgfpRLGIIGAAIATTIANVLNLIILVYLCRKIKKLTFKLSNTKVLKANIRPYKFTI 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 234 VLGIPIMIATMLEHALFSGAALLAGTLGAVSLAIHQIAMQCLNFSWNLAFGLSQAASILVSQHFGKDEPDMVRQYAKLGL 313
Cdd:cd13135 232 KLGLPLGGEEFLWNIGNLAVIRILNRIGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICL 311
|
330 340
....*....|....*....|....*.
gi 1755589622 314 GLVTATSAVIGILLSIWPEFLTHVFS 339
Cdd:cd13135 312 GLGLLIYIAAAIVFLAFPYKILSLFT 337
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
238-404 |
3.34e-12 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 64.12 E-value: 3.34e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 238 PIMIATMLEHALFSGAALLAGTLGAVSLAIHQIAMQCLNFSWNLAFGLSQAASILVSQHFGKDEPDMVRQYAKLGLGLVT 317
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 318 ATSAVIGILLSIWPEFLTHVFSIEGDALAeqLVAQLpgvMIMVALCFVVDAWQLSAISILRGMKVVVGPTISTVIGYwFV 397
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQDEEVLA--LAKRY---LRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISL-LL 154
|
....*..
gi 1755589622 398 GLPAAYL 404
Cdd:pfam01554 155 NIPLNYL 161
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
228-440 |
3.38e-09 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 58.62 E-value: 3.38e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 228 IMKPLMVLGIPIMIATMLEHALFSGAALLAGTLGAVSLAIHQIAMQCLNFSWNLAFGLSQAASILVSQHFGKDEPDMVRQ 307
Cdd:COG0534 6 ILKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDREEARR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 308 YAKLGLGLVTATSAVIGILLSIWPEFLTHVFSIEGDALAEQLvaqlpGVMIMVALCFVVDAWQLSAISILRGMKVVVGPT 387
Cdd:COG0534 86 VLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALAR-----DYLRIILLGLPFLLLFNVLNGILRGLGDTKTPM 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1755589622 388 ISTVIGYwFVGLPAAYLLMKWAGLeGIWG-GLA--IGLAATGVMLVVLLFKNLSAF 440
Cdd:COG0534 161 IIMLIGN-VLNIVLDPLLIFGGGL-GVAGaALAtvISQAVSALLLLYYLFRKRSLL 214
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
2-346 |
3.43e-08 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 55.40 E-value: 3.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 2 KTLIKLAVPLIISQLIAQMLIFTDVWMMAKLSIVAIAGGGLGAAVYSFVFIIASS-TVGCVAnLIAIAYGKQLRQPEKG- 79
Cdd:cd13141 11 KHIISMALPIAIGMIIQTLYFLVDLYFVGQLGDAALAGVSLAGNVMFFVMALTQVlNVGTAA-LVSHAVGRKDQGEANAv 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 80 -EHDVRLALKGGILLAVLLTLSLQPLFYLMkgwllkaGQDPEAVDLAITYLHAMKWSMLPTLILLVLRSLVSAFSETRSI 158
Cdd:cd13141 90 fNQSLLLAAVLGLVVLVLGYLFGRLYLETL-------AADAATVEAATTYLYWFIPSLALQFILTVLGAALRGTGIVKPF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 159 MVMSLITVILNVPLSYLLAFTL----KMGIAGLGYGTSLAAFIVMIGYGYWVFSRPKYRRyMPFRDFHEyRLGIMKPLMV 234
Cdd:cd13141 163 MVIQILAVLLNIILAPILITGWgtgrALGVAGAGLASSISVAIAVVLLLYYFLRLEKYLR-LDLALWRP-DLPTWKRLLK 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 235 LGIPimiatmlehalfSGA--ALLAGTLGAVSLAIHQIA-------------MQCLNFSwnlAFGLSQAASILVSQHFGK 299
Cdd:cd13141 241 IGLP------------SGGefLLTFVYMAVIYWALRPFGaaaqagfgigsriMQSLFLP---AMAIAFAAPAIAGQNFGA 305
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1755589622 300 DEPDMVRQYAKLGLGLVTATSAVIGILLSIWPEFLTHVFSIEGDALA 346
Cdd:cd13141 306 GNYDRVRETFRITAILTTALMLVLTLLCQLVPELLVTPFSDDAAVIA 352
|
|
| vmrA |
PRK09575 |
MATE family efflux transporter; |
104-432 |
8.58e-08 |
|
MATE family efflux transporter;
Pssm-ID: 236576 [Multi-domain] Cd Length: 453 Bit Score: 54.23 E-value: 8.58e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 104 LFYLMKGWLLKAGQDPEAVDLAITYLHAMKWSMLPTLILLVLRSLV-SAFSETRSIMVMsLITVILNVPLSYLLAFTLKM 182
Cdd:PRK09575 110 LFLFADDFLRAQGAEGRTLELALQYIQVLIWGCLFTLGAIALPFLLrNDESPNLATGLM-VIGALINIVLDYLFIGWLDW 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 183 GIAGLGYGTSLAAFIVMI-GYGYWVFSRPKYRRYMPFRDFHE------YRLGIMKPLMVLGIPIMIAtmLEHALFS--GA 253
Cdd:PRK09575 189 GLTGAAIATALAQLVVTVlGLGYFFSSRANIRLTLKELRFNWslapkiVLLGSSSFFMYLYGSFVVA--LHNRLFMeyGS 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 254 ALLAGtlgavSLAIHQIAMQCLNFswnLAFGLSQAASILVSQHFGKDEPDMVRQYAKLGLGLVTATSAVIGILLSIWPEF 333
Cdd:PRK09575 267 ALTVG-----AYAIVGYLMVLYYL---VAEGIAEGMQPPVSYYFGARQYDNIKKLLKLAMKVTVLAGIAWVLLLNLFPET 338
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 334 LTHVFSIEGDALAEQLVAQ---------LPGVMIMVALCFVvdawqlsaiSILRGMKVVVgptIStvIGYWFVGLPAAYL 404
Cdd:PRK09575 339 MIALFNSGDSELIAETIVGirlhlfamfLDGFLVLASAYFM---------AVNQGGKALF---IS--IGNMLIQLPFLFI 404
|
330 340
....*....|....*....|....*...
gi 1755589622 405 LMKWAGLEGIWggLAIGLAATGVMLVVL 432
Cdd:PRK09575 405 LPKWLGVDGVW--LAMPLSNIALSLVVA 430
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
227-329 |
1.91e-07 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 52.96 E-value: 1.91e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 227 GIMKPLMVLGIPIMIATMLEHALFSGAALLAGTLGAVSLAIHQIAMQCLNFSWNLAFGLSQAASILVSQHFGKDEPDMVR 306
Cdd:cd13142 8 SILRTLLKLAWPIIVSNLLQVAYNLADTFWLGRLGADAVAAPSISWPLIFLFISLGGGLTVAGTALVAQYTGAGDYDKAN 87
|
90 100
....*....|....*....|...
gi 1755589622 307 QYAKLGLGLVTATSAVIGILLSI 329
Cdd:cd13142 88 KVAGQTFSFVIILSLILAVLGYI 110
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
4-430 |
2.52e-07 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 52.60 E-value: 2.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 4 LIKLAVPLIISQLIAQMLIFTDVWMMAKLSIVAIAGGGLGAAVYsfvFIIASSTVGC---VANLIAIAYGKqlRQPEKGE 80
Cdd:cd13145 11 IRKLAIPASVGFFFNTMFNVVDTFFAGKISTEALAALSLSFPIF---FIIIAIGVGIgtgTTALIGNALGA--GDRRKAR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 81 HDVR----LALKGGILLAVLLTLSLQPLFYLMkgwllkaGQDPEAVDLAITYLHAMKWSMLPTLILLVLRSLVSAFSETR 156
Cdd:cd13145 86 RYAAqglsFGIILAILLTVIGLFAAPPLFRLL-------GAEGDYLDLALEYMDVIFAGSIFFLLNFGLNGILNAQGDTK 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 157 SIMVMSLITVILNVPLSYLLAF----TLKMGIAGLGYGTSLAAFIVMIgYGYWVFSRPKYRRYMPFRDFhEYRLGIMKPL 232
Cdd:cd13145 159 SYRNFLIIGFFLNIILDPLFIFggggIPAMGVSGIALATIISQFIGMF-YLLYKVRKSGIISGCRLRDF-IPRLDVYKEI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 233 MVLGIPIMIATMLEHALFSGAALLAGTLGAVSLAIHQIAMQCLNFSWNLAFGLSQAASILVSQHFGKDEPDMVRQYAKLG 312
Cdd:cd13145 237 LKQGFPASLNMMTIGLGIFVITYFVGQFGDEAVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKYDRVRETYKKA 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 313 L--GLVTATSAVIGILLSiwPEFLTHVFSiegdalaeqlvaQLPGVMIMVALCFVVDAWQLSA-------ISILRGMKvv 383
Cdd:cd13145 317 LkyGFVIMVVATVFLLFF--AEPLMSLFT------------NDPAVIAIGAGYLRIDALIFYAyvvlfisVSVLQGLK-- 380
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 1755589622 384 vGPTISTVIG-YWFVGLPAA--YLLMKWAGLE--GIWGGLAIGLAATGVMLV 430
Cdd:cd13145 381 -RPIFALWIGlYRQLVGPALvfWLLVNVLGLGvtGIWWGIFTIVWSAAIIAL 431
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
10-175 |
3.57e-07 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 49.87 E-value: 3.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 10 PLIISQLIAQMLIFTDVWMMAKLSIVAIAGGGLGAAVYSFVFIIASSTVGCVANLIAIAYGKqlRQPEKGEHDVRLALKG 89
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGA--GNFKRAGVALRQGLIL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 90 GILLAVLLTLSlqpLFYLMKGWLLKAGQDPEAVDLAITYLHAMKWSMLPTLILLVLRSLVSAFSETRSIMVMSLITVILN 169
Cdd:pfam01554 79 GLLLSLPIALL---VLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLN 155
|
....*.
gi 1755589622 170 VPLSYL 175
Cdd:pfam01554 156 IPLNYL 161
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
2-435 |
4.72e-07 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 51.92 E-value: 4.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 2 KTLIKLAVPLIISQLIAQMLIFTDVWMMAKLSivaIAGGGLGAAVYSFVFIIASSTVGC---VANLIAIAYGKQLRQPEK 78
Cdd:cd13149 9 RHLIKLTLPMIFGILAMLIFNLTDTFFVGKLG---TKELAAISFTFPVVLFLNSLTIGLgigASAVISRAIGAGDRNKAK 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 79 --GEHDVRLALKGGILLAVLLTLSLQPLFYLMkgwllkaGQDPEAVDLAITYLHAMKWSMLPTLILLVLRSLVSAFSETR 156
Cdd:cd13149 86 rlATDSLILSLLLSVIVSLLGLFTIPPLFSLL-------GASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGDTK 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 157 SIMVMSLITVILNVPLSYLLAF----TLKMGIAGLGYGTSLAAFIVMIGYGYWVFSRPK--YRRYMPFRDFheyrLGIMK 230
Cdd:cd13149 159 RPSLVMLGAALVNVILDPILIFgfgpIPGMGIAGAAIATVISRALGLGAALYFLHYHHRliDFSEPSLKAL----FRSWK 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 231 PLMVLGIPIMIATMLEHALFSGAALLAGTLGAVSLAIHQIAMQCLNFSWNLAFGLSQAASILVSQHFGKDEPDMVRQYAK 310
Cdd:cd13149 235 DILSIGIPAALSNILTPLSAAFITALVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGLK 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 311 LGLGLVTATSAVIGILLSIWPEFLTHVFSIEGDALAeqLVAQLpgvMIMVALCFVVDAWQLSAISILRGMKVVVGPTIST 390
Cdd:cd13149 315 ISLKFSLIYGAILGIVLALFAGWLASLFSAEPEVIE--LITLY---LLIVPIGYGGLGILIITSASFNALGKPLYSLGLN 389
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 1755589622 391 VIGYWFVGLPAAYLLMKWAGLEGIWGGLAIGLAATGVMLVVLLFK 435
Cdd:cd13149 390 LIRVFLLYIPLAYVGSHLLGFAGVFIGALAGNLIAGILAYFIAKK 434
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
2-434 |
5.70e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 48.42 E-value: 5.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 2 KTLIKLAVPLIISQLIAQMLIFTDVWMMAKLSIVAIAGGGLGAAVYSFVFIIASSTVG-CVANLIAIAYGKQLRqpEKGE 80
Cdd:cd13148 12 PTLLRLALPNILALLVQTLVGLAETYFVGQLGTDALAGVALVFPLLMLTQMMSNGAMGgGVSSAIARALGAGDR--ERAE 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 81 ----HDVRLALKGGILLAVLLTLSLQPLFYLMkgwllkaGQDPEAVDLAITYLHAMKWSMLPTLILLVLRSLVSAFSETR 156
Cdd:cd13148 90 alvwHALVIALAGGLVFSLLFLLFGPALYRLL-------GGRGEALDAALAYSNVLFSGAILIWLVNLLAAALRGTGNMR 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 157 SIMVMSLITVILNVPLSYLLAFTL----KMGIAGLGYG---TSLAAFIVMIGYGYWVFSRPKYRRYMPfrdfhEYRLGIM 229
Cdd:cd13148 163 VPALVTLVGAVVQIPLSPGLILGWgplpRLGVAGAAVAavlYYALAALVLLRYLASGRSRLRLRLRAL-----RLERRLF 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 230 KPLMVLGIPIMIATMLEHALFSGAALLAGTLGAVSLAIHQIAMQCLNFSWNLAFGLSQAASILVSQHFGKDEPDMVRQYA 309
Cdd:cd13148 238 RDILRVGLLAALSPLQTNLTVLLLTGLVGRFGTAALAGYGIGSRLEFLLIPLVFGLGAAMTAMVGMNIGAGQIARARRIA 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 310 KLGLGLVTATSAVIGILLSIWPEFLTHVFSieGDALAEQLVAQLpgvMIMVALCFVVDAWQLSAISILRGMKVVVGPTIS 389
Cdd:cd13148 318 WTGALMAAVLAGAIGLVLALFPELWLGLFT--HDPAVLAAGASY---LRIVGPFYGFFGLGLALYFASQGAGRMLWPVLA 392
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 1755589622 390 TVIGYwFVGLPAAYLLMKW--AGLEGIWGGLAIGLAATGVMLVVLLF 434
Cdd:cd13148 393 GTLRL-LIAAGGGWIAVALfgAGLAGLFAAAAAAMVAYGLVTAAAVK 438
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
1-209 |
3.06e-05 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 45.97 E-value: 3.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 1 MKTLIKLAVPLIISQLIAQMLIFTDVWMMAKLSIVAIAGGGLGAAVYSFVFIIASSTVGCVANLIAIAYGKqlRQPEKGE 80
Cdd:cd13137 225 IKKLLRIGLPAGLEQLLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGA--GDPDEAR 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 81 HDVRLALKGGILLAVLLTLslqpLFYLMKGWLLKA-GQDPEAVDLAITYLHAMKWSMLPTLILLVLRSLVSAFSETRSIM 159
Cdd:cd13137 303 RYGKRALRLGVLFMGLLGL----LLFIFAPPLASLfTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPL 378
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1755589622 160 VMSLITVILN-VPLSYLLAFTLKMGIAGLgYGTSLAAFIVMIGYGYWVFSR 209
Cdd:cd13137 379 IINLISMWLVrLPLAYLLGFVLGLGLTGI-WLAMFVDTIVRAILLLYRFRK 428
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
81-353 |
4.35e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 45.61 E-value: 4.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 81 HDVRLALKGGILLAVLLTLSLQPLFYLMKgwllkAGqdpEAVDLAITYLHAMKWSMLPTLILLVLRSLVSAFSETRSIMV 160
Cdd:cd13147 90 HSILLGLIISIILTIVLLPFLEPILVLMG-----AG---EVLDLAVDYGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMY 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 161 MSLITVILNVPLSYLLAFTLKMGIAGLGYGTSLAAFIVMIGYGYWVFSRPKYRRYMPFRDFHeYRLGIMKPLMVLGIPim 240
Cdd:cd13147 162 AMVAGSILNIILDPIFIYTLGLGIAGAAWATVISMLISSLVLLYWFFVKKDTYVSLSLKNFK-FDKKIVKDILKVGIP-- 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 241 iaTMLEHALFSGAA-----LLAGTLGAVSLAIHQIAMQCLNFSWNLAFGLSQAASILVSQHFGKDEPDMVRQYAKLGLGL 315
Cdd:cd13147 239 --ASLEQLIMSVLMiilnlILVIVAGTDGVAVYTAGWRIVSFAIIPLIGIATAVTSVTGAAYGARNYEKLKTAYNYSIKL 316
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 1755589622 316 VTATSAVIGILLSIWPEFLTHVFSIEGDA--LAEQLVAQL 353
Cdd:cd13147 317 GLIIELIIAILIFIFAPQIAYLFTYSEESahLAPEIVAFL 356
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
228-329 |
1.49e-04 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 43.99 E-value: 1.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 228 IMKPLMVLGIPIMIATMLeHALFSGAALL-----AGTLGAVSLAIHQIAMQCLNfswNLAFGLSQAASILVSQHFGKDEP 302
Cdd:cd13138 1 ILKTLLLFALPLLLSNLL-QQLYNLVDLLivgqfLGVAALAAVSNGSPIIFLLT---AIGMGLSMGGTILISQYIGAKDE 76
|
90 100
....*....|....*....|....*..
gi 1755589622 303 DMVRQYAklglGLVTATSAVIGILLSI 329
Cdd:cd13138 77 EKAKKAV----GTLLVLFLILGIVLTI 99
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
118-209 |
1.92e-04 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 43.60 E-value: 1.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 118 DPEAVDLAITYLHAMKWSMLPTLILLVLRSLVSAFSETRSIMVMSLITVILNVPLSYLLAFTlkMGIAGLGYGTSLAAFI 197
Cdd:cd13123 331 TAEDTLMTASALAAYALGLPAFALVKLLSRAFYALKDTKTPVKIAVIAVAVNILLNLLLIKP--LGHVGLALATSLSAWV 408
|
90
....*....|..
gi 1755589622 198 VMIgYGYWVFSR 209
Cdd:cd13123 409 NAL-LLLVLLRR 419
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
2-421 |
8.38e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 41.62 E-value: 8.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 2 KTLIKLAVPLIISQLIAQMLIFTDVWMMAKLSIVAIAGGGLGAAVYSFVFI---IASSTVGCVANLIAIAYGKQlrqpek 78
Cdd:cd13146 8 PLLIRLALPILIGQLFQLLYNITDTIWISMIDPSDPALVGGIGLVFPLGMIflaLGNGIQVGVSSLLARAIGAQ------ 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 79 GEHDVRLALKGGILLAVLLTLSLQPLFYLMKGWLLKA-GQDPEAVDLAITYLHAMKWSMLPTLILLVLRSLVSAFSETRS 157
Cdd:cd13146 82 RAKELDQAADSGLALALLAATVIVVLGYIFAEPLLQLlGAKGLLLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTKY 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 158 IMVMSLITVILNVPLSYLLAFTLKMGIAGLGYGTSLAAFIVMIgYGYWVFSRPKYRRYMPFRdFHEYRLGIMKPLMVLGI 237
Cdd:cd13146 162 MMMAMLIGTVVNIVLDPILIFVFDMGVKGAALATVLAQAISLL-YLLYVFLIGKSNVTIHIK-LSNISSSVIVEILRVGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 238 PIMIATMLEHALFSGAALLAGTLGAVSLAIHQIAMQCLNFSWNLAFGLSQAASILVSQHFGKDEPDMVRQYAKLGLGLVT 317
Cdd:cd13146 240 PQMLLQLISSISFLIYNRIIIDIDPVAMTAFTLVGRLDQFILIPIFAISSALLTIAGQNWGRGNYDRMLQILMTAVILGI 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 318 ATSAVIGILLSIWPEFLTHVFSIEGDALaEQLVAQLPgvmiMVALCFVVDAWQLSAISILRGMKVVVGPTISTVIGYWFV 397
Cdd:cd13146 320 VVVLVLVLGYVLVAPWLFSLFTTVPEVV-AYAVLQVR----TMALALPFVAISILVTEFFQAIGKAWPSLLLTLIRHVFL 394
|
410 420
....*....|....*....|....*.
gi 1755589622 398 GLPAAYLL--MKWAGLEGIWGGLAIG 421
Cdd:cd13146 395 SVPVVYLLayVFGKGITGVYFGIVSA 420
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
118-284 |
8.85e-04 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 41.67 E-value: 8.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 118 DPEAVDLAITYLHAMKWSMLPTLILLVLRSLVSAFSETRSIMVMSLITVILNVPLSYLLAFTlkMGIAGLGYGTSLAAFI 197
Cdd:COG0728 338 TAEDTALTALALAAYALGLPAFALVKVLARAFYARQDTRTPVRIAVIAVVVNIVLNLLLVPP--LGHAGLALATSLSALV 415
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 198 VMIGYGYWVfsrpkyRRYMPFRDFHEYRLGIMKPLMVLGIPIMIATMLEHAL-------FSGAALLAGTLGAVSLAIHQI 270
Cdd:COG0728 416 NALLLLVLL------RRRLGGLPLRGILRTLLKLLLASLVMGAVLWLLLRLLgdwlgggLLGRLLALALLILVGAAVYFA 489
|
170
....*....|....
gi 1755589622 271 AMQCLNFSWNLAFG 284
Cdd:COG0728 490 LLLLLGVRLRDLLR 503
|
|
| PRK10367 |
PRK10367 |
DNA-damage-inducible SOS response protein; Provisional |
2-278 |
5.84e-03 |
|
DNA-damage-inducible SOS response protein; Provisional
Pssm-ID: 182413 [Multi-domain] Cd Length: 441 Bit Score: 38.95 E-value: 5.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 2 KTLIKLAVPLIISQLIAQMLIFTDVWMMAKL-SIVAIAGGGLGAAVYSFVFI----IASSTVGCVANLIA----IAYGKQ 72
Cdd:PRK10367 9 KALWRLALPMIFSNITVPLLGLVDTAVIGHLdSPVYLGGVAVGATATSFLFMlllfLRMSTTGLTAQAFGaknpQALARA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 73 LRQPekgehdVRLALKGGILLAVLLtlslQPLFYLMkgwLLKAGQDPEAVDLAITYLHAMKWSMLPTLILLVLRSLVSAF 152
Cdd:PRK10367 89 LVQP------LLLALGAGALIALLR----TPLIDLA---LHIVGGSEAVLEQARRFLEIRWLSAPASLANLVLLGWLLGV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 153 SETRSIMVMSLITVILNVPLSYLLAFTLKMGIAGLGYGTSLAAFIVMIgYGYWVFSRPKYRRYMPFRDFHEYRLGIMKPL 232
Cdd:PRK10367 156 QYARAPVILLVVGNILNIVLDLWLVMGLHMNVQGAALATVIAEYATLL-IGLLMVRKVLKLRGISLEMLKTAWRGNFRRL 234
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1755589622 233 MVLGIPIMIATMLEHALFSGAALLAGTLGAVSLAIHQIAMQCLNFS 278
Cdd:PRK10367 235 LALNRDIMLRSLLLQLCFGAITVLGARLGSDIIAVNAVLMTLLTFT 280
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
124-338 |
9.33e-03 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 38.29 E-value: 9.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 124 LAITYLHAMKWSMLPTLILLVLRSLVSAFSETRSIMVMSLITVILNVPLSYLLAFtLKMGIAGLGYGTSLAAFIVMIGYG 203
Cdd:cd13128 107 ELVLLLYILALSLPFSALNSLFRGIFQGFEKMKYIVIARIIESVLSLILALILVL-LGGGLIGFALAYLIASVLSAILLL 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1755589622 204 YWvfsrpkYRRYMPFRDFHEYRLGIMKPLMVLGIPIMIATMLEHALFSGAALLAGT-LGAVSLAIHQIAMQCLNFSWNLA 282
Cdd:cd13128 186 YI------YRKKILLPKFFSFDLKLAKELLRFSIPLALSGIFSLIYTRIDTIMLGYfLGDAAVGIYNAAYRIAELLLFIP 259
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1755589622 283 FGLSQAASILVSQHFGKDEpDMVRQYAKLGLGLVTATSAVIGILLSIWPEFLTHVF 338
Cdd:cd13128 260 SAISTALFPRISELYKNDK-DELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLL 314
|
|
| |
