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Conserved domains on  [gi|1759768995|gb|KAB2751007|]
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BolA family transcriptional regulator [Brucella anthropi]

Protein Classification

BolA family protein( domain architecture ID 10000955)

BolA family protein may be a stress-responsive transcriptional regulator and may also participate in iron metabolism; similar to mammalian BolA-like proteins that act as iron-sulfur (Fe-S) cluster assembly factors that facilitate [2Fe-2S] cluster insertion into a subset of cytosolic proteins, and to Haemophilus influenzae DNA-binding transcriptional regulator BolA

CATH:  3.30.300.90

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BolA COG0271
DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and ...
 6-104 2.92e-36

DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and biofilm formation [Transcription, Signal transduction mechanisms];


:

Pssm-ID: 440041  Cd Length: 90  Bit Score: 117.98  E-value: 2.92e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759768995   6 SKQSAMEAKLTTAFAPERLEVINESHLHAghhheerghheVYDG-TGETHFRIRIVAQAFAGMSRIQRHRAINELLKEEL 84
Cdd:COG0271     2 SRQERIEEKLTAALAPEHLEVIDESHLHA-----------GHAGaGGESHFKVVIVSDAFAGKSRVARHRLVYAALADEL 70

                          90       100
                  ....*....|....*....|
gi 1759768995  85 DSGVHALALEPSAPGEATRR 104
Cdd:COG0271    71 AGGIHALAIHAYTPEEWQAR 90
 
Name Accession Description Interval E-value
BolA COG0271
DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and ...
 6-104 2.92e-36

DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and biofilm formation [Transcription, Signal transduction mechanisms];


Pssm-ID: 440041  Cd Length: 90  Bit Score: 117.98  E-value: 2.92e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759768995   6 SKQSAMEAKLTTAFAPERLEVINESHLHAghhheerghheVYDG-TGETHFRIRIVAQAFAGMSRIQRHRAINELLKEEL 84
Cdd:COG0271     2 SRQERIEEKLTAALAPEHLEVIDESHLHA-----------GHAGaGGESHFKVVIVSDAFAGKSRVARHRLVYAALADEL 70

                          90       100
                  ....*....|....*....|
gi 1759768995  85 DSGVHALALEPSAPGEATRR 104
Cdd:COG0271    71 AGGIHALAIHAYTPEEWQAR 90
BolA pfam01722
BolA-like protein; This family consist of the morphoprotein BolA from E. coli and its various ...
 15-100 1.27e-31

BolA-like protein; This family consist of the morphoprotein BolA from E. coli and its various homologs. In E. coli over expression of this protein causes round morphology and may be involved in switching the cell between elongation and septation systems during cell division. The expression of BolA is growth rate regulated and is induced during the transition into the the stationary phase. BolA is also induced by stress during early stages of growth and may have a general role in stress response. It has also been suggested that BolA can induce the transcription of penicillin binding proteins 6 and 5.


Pssm-ID: 460305  Cd Length: 75  Bit Score: 106.00  E-value: 1.27e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759768995  15 LTTAFAPERLEVINESHLHAghhheerghheVYDGTGETHFRIRIVAQAFAGMSRIQRHRAINELLKEELDSGVHALALE 94
Cdd:pfam01722   1 LTEALAPTHLEVEDESHKHA-----------GHAGGGETHFKVVIVSDAFEGKSLVARHRLVYDALADELAGGIHALSIK 69


                  ....*.
gi 1759768995  95 PSAPGE 100
Cdd:pfam01722  70 TYTPEE 75
PRK11628 PRK11628
transcriptional regulator BolA; Provisional
 11-93 6.76e-15

transcriptional regulator BolA; Provisional


Pssm-ID: 183243  Cd Length: 105  Bit Score: 64.42  E-value: 6.76e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759768995  11 MEAKLTTAFAPERLEVINESHLHaghhheerghhEVYDGTgETHFRIRIVAQAFAGMSRIQRHRAINELLKEELDSGVHA 90
Cdd:PRK11628    7 IEEKLRAAFQPVFLEVVDESYRH-----------NVPAGS-ESHFKVVLVSDRFTGERFLNRHRMIYSTLAEELSTTVHA 74


                  ...
gi 1759768995  91 LAL 93
Cdd:PRK11628   75 LAL 77
 
Name Accession Description Interval E-value
BolA COG0271
DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and ...
 6-104 2.92e-36

DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and biofilm formation [Transcription, Signal transduction mechanisms];


Pssm-ID: 440041  Cd Length: 90  Bit Score: 117.98  E-value: 2.92e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759768995   6 SKQSAMEAKLTTAFAPERLEVINESHLHAghhheerghheVYDG-TGETHFRIRIVAQAFAGMSRIQRHRAINELLKEEL 84
Cdd:COG0271     2 SRQERIEEKLTAALAPEHLEVIDESHLHA-----------GHAGaGGESHFKVVIVSDAFAGKSRVARHRLVYAALADEL 70

                          90       100
                  ....*....|....*....|
gi 1759768995  85 DSGVHALALEPSAPGEATRR 104
Cdd:COG0271    71 AGGIHALAIHAYTPEEWQAR 90
BolA pfam01722
BolA-like protein; This family consist of the morphoprotein BolA from E. coli and its various ...
 15-100 1.27e-31

BolA-like protein; This family consist of the morphoprotein BolA from E. coli and its various homologs. In E. coli over expression of this protein causes round morphology and may be involved in switching the cell between elongation and septation systems during cell division. The expression of BolA is growth rate regulated and is induced during the transition into the the stationary phase. BolA is also induced by stress during early stages of growth and may have a general role in stress response. It has also been suggested that BolA can induce the transcription of penicillin binding proteins 6 and 5.


Pssm-ID: 460305  Cd Length: 75  Bit Score: 106.00  E-value: 1.27e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759768995  15 LTTAFAPERLEVINESHLHAghhheerghheVYDGTGETHFRIRIVAQAFAGMSRIQRHRAINELLKEELDSGVHALALE 94
Cdd:pfam01722   1 LTEALAPTHLEVEDESHKHA-----------GHAGGGETHFKVVIVSDAFEGKSLVARHRLVYDALADELAGGIHALSIK 69


                  ....*.
gi 1759768995  95 PSAPGE 100
Cdd:pfam01722  70 TYTPEE 75
PRK11628 PRK11628
transcriptional regulator BolA; Provisional
 11-93 6.76e-15

transcriptional regulator BolA; Provisional


Pssm-ID: 183243  Cd Length: 105  Bit Score: 64.42  E-value: 6.76e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759768995  11 MEAKLTTAFAPERLEVINESHLHaghhheerghhEVYDGTgETHFRIRIVAQAFAGMSRIQRHRAINELLKEELDSGVHA 90
Cdd:PRK11628    7 IEEKLRAAFQPVFLEVVDESYRH-----------NVPAGS-ESHFKVVLVSDRFTGERFLNRHRMIYSTLAEELSTTVHA 74


                  ...
gi 1759768995  91 LAL 93
Cdd:PRK11628   75 LAL 77
IbaG COG5007
Acid stress protein IbaG/YrbA, BolA-like family [Signal transduction mechanisms];
54-104 1.85e-11

Acid stress protein IbaG/YrbA, BolA-like family [Signal transduction mechanisms];


Pssm-ID: 444031  Cd Length: 81  Bit Score: 54.77  E-value: 1.85e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1759768995  54 HFRIRIVAQAFAGMSRIQRHRAINELLKEELDSG-VHALALEPSAPGEATRR 104
Cdd:COG5007    27 HFEAIVVSDAFEGLSRVKRQQLVYAPLGDYIASGeIHALSIKTYTPEEWAAQ 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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