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Conserved domains on  [gi|1759772872|gb|KAB2754817|]
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helix-turn-helix transcriptional regulator [Brucella anthropi]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 16677510)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
sulf_sens_BigR NF040642
sulfite-sensing transcriptional repressor BigR; BigR (biofilm growth-associated repressor) is ...
 18-112 4.22e-55

sulfite-sensing transcriptional repressor BigR; BigR (biofilm growth-associated repressor) is a winged-helix DNA-binding protein active as a transcriptional regulator for Blh, a bifunctional sulfur transferase/dioxygenase found in a number of plant-associated bacteria. Oxidative conditions that allow disulfide bond formation between the invariant residues Cys42 and Cys108 cause BigR to lose DNA-binding transcriptional repressor activity.


:

Pssm-ID: 468610  Cd Length: 95  Bit Score: 166.47  E-value: 4.22e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759772872  18 TEMEGRATEVAELLKTLSHPARLMLACTLAEREYSVGELEEALGIHQPTLSQQLGVLREAGIVETRREAKQIFYRLTEAK 97
Cdd:NF040642    1 AEMEARAGEVADLLKTLAHPARLMLVCTLVEGEYSVGELEEKLDIHQPTLSQQLTVLREAGIVETRREGKQIFYRLTEEK 80

                          90
                  ....*....|....*
gi 1759772872  98 AAQLIEALYGIFCAP 112
Cdd:NF040642   81 AAQLVGALYTIFCAK 95
 
Name Accession Description Interval E-value
sulf_sens_BigR NF040642
sulfite-sensing transcriptional repressor BigR; BigR (biofilm growth-associated repressor) is ...
 18-112 4.22e-55

sulfite-sensing transcriptional repressor BigR; BigR (biofilm growth-associated repressor) is a winged-helix DNA-binding protein active as a transcriptional regulator for Blh, a bifunctional sulfur transferase/dioxygenase found in a number of plant-associated bacteria. Oxidative conditions that allow disulfide bond formation between the invariant residues Cys42 and Cys108 cause BigR to lose DNA-binding transcriptional repressor activity.


Pssm-ID: 468610  Cd Length: 95  Bit Score: 166.47  E-value: 4.22e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759772872  18 TEMEGRATEVAELLKTLSHPARLMLACTLAEREYSVGELEEALGIHQPTLSQQLGVLREAGIVETRREAKQIFYRLTEAK 97
Cdd:NF040642    1 AEMEARAGEVADLLKTLAHPARLMLVCTLVEGEYSVGELEEKLDIHQPTLSQQLTVLREAGIVETRREGKQIFYRLTEEK 80

                          90
                  ....*....|....*
gi 1759772872  98 AAQLIEALYGIFCAP 112
Cdd:NF040642   81 AAQLVGALYTIFCAK 95
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
19-109 1.95e-29

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 101.50  E-value: 1.95e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759772872  19 EMEGRATEVAELLKTLSHPARLMLACTLAEREYSVGELEEALGIHQPTLSQQLGVLREAGIVETRREAKQIFYRLTEAKA 98
Cdd:COG0640     2 SETKELEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEAL 81

                          90
                  ....*....|.
gi 1759772872  99 AQLIEALYGIF 109
Cdd:COG0640    82 AELLEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 27-102 3.38e-26

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 92.91  E-value: 3.38e-26
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1759772872  27 VAELLKTLSHPARLMLACTLAEREYSVGELEEALGIHQPTLSQQLGVLREAGIVETRREAKQIFYRLTEAKAAQLI 102
Cdd:NF033788    1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
46-105 1.25e-18

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 73.40  E-value: 1.25e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759772872   46 LAEREYSVGELEEALGIHQPTLSQQLGVLREAGIVETRREAKQIFYRLTEAKAAQLIEAL 105
Cdd:smart00418   6 LAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 31-105 1.94e-17

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 70.79  E-value: 1.94e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1759772872  31 LKTLSHPARLMLACTLAEREYSVGELEEALGIHQPTLSQQLGVLREAGIVETRREAKQIFYRLTEA-KAAQLIEAL 105
Cdd:cd00090     1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDAeRLLALLESL 76
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 36-80 6.21e-11

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 53.22  E-value: 6.21e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1759772872  36 HPARLMLACTLAEREYSVGELEEALGIHQPTLSQQLGVLREAGIV 80
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 29-106 9.74e-09

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 49.43  E-value: 9.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759772872  29 ELLKTLSHPARLMLACTLAER-EYSVGELEEALGIHQPTLSQQLGVLREAGIVETRREAKQIFYRLT---EAKAAQLIEA 104
Cdd:PRK10141    8 QLFKILSDETRLGIVLLLRESgELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLSphiPAWAAKIIEQ 87


                  ..
gi 1759772872 105 LY 106
Cdd:PRK10141   88 AW 89
 
Name Accession Description Interval E-value
sulf_sens_BigR NF040642
sulfite-sensing transcriptional repressor BigR; BigR (biofilm growth-associated repressor) is ...
 18-112 4.22e-55

sulfite-sensing transcriptional repressor BigR; BigR (biofilm growth-associated repressor) is a winged-helix DNA-binding protein active as a transcriptional regulator for Blh, a bifunctional sulfur transferase/dioxygenase found in a number of plant-associated bacteria. Oxidative conditions that allow disulfide bond formation between the invariant residues Cys42 and Cys108 cause BigR to lose DNA-binding transcriptional repressor activity.


Pssm-ID: 468610  Cd Length: 95  Bit Score: 166.47  E-value: 4.22e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759772872  18 TEMEGRATEVAELLKTLSHPARLMLACTLAEREYSVGELEEALGIHQPTLSQQLGVLREAGIVETRREAKQIFYRLTEAK 97
Cdd:NF040642    1 AEMEARAGEVADLLKTLAHPARLMLVCTLVEGEYSVGELEEKLDIHQPTLSQQLTVLREAGIVETRREGKQIFYRLTEEK 80

                          90
                  ....*....|....*
gi 1759772872  98 AAQLIEALYGIFCAP 112
Cdd:NF040642   81 AAQLVGALYTIFCAK 95
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
19-109 1.95e-29

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 101.50  E-value: 1.95e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759772872  19 EMEGRATEVAELLKTLSHPARLMLACTLAEREYSVGELEEALGIHQPTLSQQLGVLREAGIVETRREAKQIFYRLTEAKA 98
Cdd:COG0640     2 SETKELEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEAL 81

                          90
                  ....*....|.
gi 1759772872  99 AQLIEALYGIF 109
Cdd:COG0640    82 AELLEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 27-102 3.38e-26

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 92.91  E-value: 3.38e-26
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1759772872  27 VAELLKTLSHPARLMLACTLAEREYSVGELEEALGIHQPTLSQQLGVLREAGIVETRREAKQIFYRLTEAKAAQLI 102
Cdd:NF033788    1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
46-105 1.25e-18

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 73.40  E-value: 1.25e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759772872   46 LAEREYSVGELEEALGIHQPTLSQQLGVLREAGIVETRREAKQIFYRLTEAKAAQLIEAL 105
Cdd:smart00418   6 LAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 31-105 1.94e-17

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 70.79  E-value: 1.94e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1759772872  31 LKTLSHPARLMLACTLAEREYSVGELEEALGIHQPTLSQQLGVLREAGIVETRREAKQIFYRLTEA-KAAQLIEAL 105
Cdd:cd00090     1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDAeRLLALLESL 76
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 36-80 6.21e-11

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 53.22  E-value: 6.21e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1759772872  36 HPARLMLACTLAEREYSVGELEEALGIHQPTLSQQLGVLREAGIV 80
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 28-87 3.77e-10

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 51.39  E-value: 3.77e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1759772872  28 AELLKTLSHPARL-MLACTLAEREYSVGELEEALGIHQPTLSQQLGVLREAGIVETRREAK 87
Cdd:pfam12840   1 DDVAEALADPTRLrILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
26-85 2.40e-09

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 50.34  E-value: 2.40e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759772872  26 EVAELLKTLSHPARLMLACTLAEREYSVGELEEALGIHQPTLSQQLGVLREAGIVETRRE 85
Cdd:COG4189     8 ESLEVLKALASETRLRILRLLAEEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEYK 67
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 29-106 9.74e-09

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 49.43  E-value: 9.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759772872  29 ELLKTLSHPARLMLACTLAER-EYSVGELEEALGIHQPTLSQQLGVLREAGIVETRREAKQIFYRLT---EAKAAQLIEA 104
Cdd:PRK10141    8 QLFKILSDETRLGIVLLLRESgELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLSphiPAWAAKIIEQ 87


                  ..
gi 1759772872 105 LY 106
Cdd:PRK10141   88 AW 89
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
37-95 4.55e-06

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 42.94  E-value: 4.55e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1759772872  37 PARLMLACTLAEREYSVGELEEALGIHQPTLSQQLGVLREAGIVETRREAKQIFYRLTE 95
Cdd:COG3398    98 TPRRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNP 156
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
20-96 8.19e-05

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 39.88  E-value: 8.19e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1759772872  20 MEGRATEVAELLKTLSHPARLMLActLAEREYSVGELEEALGIHQPTLSQQLGVLREAGIVETRREAkqifYRLTEA 96
Cdd:COG4742     1 MGSMKLDLLDFLFLSEKRKNILLL--LAEGPKTRSELAESLDVSRSTILRQLKELEERGLIERDDGE----YELTTL 71
Rrf2 pfam02082
Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur ...
 40-84 3.49e-03

Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur clusters enabling iron dependent DNA transcription regulation. The iron binding is mediated by three conserved cysteine residues. Members of this family can also bind O-acetyl-L-serine, [Fe-S] and nitric oxide (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 396591 [Multi-domain]  Cd Length: 131  Bit Score: 34.84  E-value: 3.49e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1759772872  40 LMLACTLAEREYSVGELEEALGIHQPTLSQQLGVLREAGIVETRR 84
Cdd:pfam02082  13 LYLALHPGGEPVTSEEIAERQNISPVYLEKILAKLRKAGLVESVR 57
PRK09834 PRK09834
DNA-binding transcriptional regulator;
52-103 3.53e-03

DNA-binding transcriptional regulator;


Pssm-ID: 182100 [Multi-domain]  Cd Length: 263  Bit Score: 35.35  E-value: 3.53e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1759772872  52 SVGELEEALGIHQPTLSQQLGVLREAGIVetRREAKQIFYRLTEaKAAQLIE 103
Cdd:PRK09834   28 TVGLLAELTGLHRTTVRRLLETLQEEGYV--RRSASDDSFRLTL-KVRQLSE 76
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
37-106 3.77e-03

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 34.11  E-value: 3.77e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1759772872   37 PARLMLACTLAERE-YSVGELEEALGIHQPTLSQQLGVLREAGIVETRREA---KQIFYRLTEaKAAQLIEALY 106
Cdd:smart00347  10 PTQFLVLRILYEEGpLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPedrRSVLVSLTE-EGRELIEQLL 82
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
52-96 4.53e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 34.90  E-value: 4.53e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1759772872  52 SVGELEEALGIHQPTLSQQLGVLREAGIVETRREAK-----QIFYRLTEA 96
Cdd:COG2345    29 TAAELAEALGLTPNAVRRHLDALEEEGLVERETERRgrgrpAKLYRLTEA 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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