|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09103 |
PRK09103 |
ribonucleoside-diphosphate reductase subunit alpha; |
4-761 |
0e+00 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181649 [Multi-domain] Cd Length: 758 Bit Score: 1844.25 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 4 SLLVTKRDGSTERINLDKIHRVLDWAAEGLNNVSISQVELRSHIQFYDGIKTADIHETIIKAAADLISREAPDYQYLAAR 83
Cdd:PRK09103 1 SLLVTKRDGRTERINLDKIHRVITWAAEGLHNVSVSQVELRSHIQFYDGIKTSDIHETIIKAAADLISRDAPDYQYLAAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 84 LAIFHLRKKAYGQFEPPALFDHVSKMVKNGKYDTHLLEDYTEEEFKQMDSFIEHDRDMTFSYAAVKQLEGKYLVQNRVTG 163
Cdd:PRK09103 81 LAIFHLRKKAYGQFEPPALYDHVVKMVEMGKYDKHLLEDYTEEEFDQMDTFIDHWRDMNFSYAAVKQLEGKYLVQNRVTG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 164 EIYESAQFLYILVAACLFSNYPRETRLDYIKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSA 243
Cdd:PRK09103 161 EIYESAQFLYILVAACLFSNYPKETRLDYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 244 IVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEVESLLVLKNNR 323
Cdd:PRK09103 241 IVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPIWHLEVESLLVLKNNR 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 324 GTDANRVRHMDYGVQINKLMYTRLLKGGDITLFSPSDVPGLYDAFFADQDEFERLYTQYEQDDSIRKQRIKAVELFSLMM 403
Cdd:PRK09103 321 GVEENRVRHMDYGVQINKLMYQRLIKGGDITLFSPSDVPGLYDAFFADQDEFERLYTKYEQDDSIRKKRVKAVELFSLMM 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 404 QERASTGRIYIQNVDHCNTHSPFDPVVAPVRQSNLCLEIALPTKPLEDVNDENGEIALCTLSAFNLGVIDSLDELEELAV 483
Cdd:PRK09103 401 QERASTGRIYIQNVDHCNTHSPFDPKVAPVRQSNLCLEIALPTKPLNDVNDENGEIALCTLSAFNLGAINSLDELEELAD 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 484 LAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAIEQG 563
Cdd:PRK09103 481 LAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKNGVRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQG 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 564 ACPWFNETTYAKGILPIDTYKKDLDAIVSESLHYDWEQLRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGHVS 643
Cdd:PRK09103 561 ACPWFNETTYAQGILPIDTYKKDLDAICNEPLHYDWETLREEIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVS 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 644 IKASKDGILRQVVPDYEKLQNGYELLWEMPNNDGYLQLVGIMQKFIDQSISANTNYDPTRFPSGKVPMQQLLKDLLNAYK 723
Cdd:PRK09103 641 IKASKDGILKQVVPDYERLKDAYELLWEMPNNDGYLQLVGIMQKFVDQSISANTNYDPSRFPSGKVPMKQLLKDLLTAYK 720
|
730 740 750
....*....|....*....|....*....|....*...
gi 1766864855 724 FGVKTLYYHNTRDGAEDAQDDLAPSIQDDGCESGACKI 761
Cdd:PRK09103 721 FGVKTLYYHNTRDGAEDAQDDLQPSIQDDGCEGGACKI 758
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
88-742 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 689.62 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 88 HLRKKAYGQFepPALFDHVsKMVKNGKYDTHLLEdyteEEFKQMDSFIEHDRDMTFSYAAVKQLEGKYLVQNrVTGEIYE 167
Cdd:COG0209 1 QLRKEALGQY--KSFSEKI-KYVEEGLYDERLLE----EDLEELAAAIDPERDRFFSYNALKTLYDRYLLKD-EDGKPLE 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 168 SAQFLYILVAACLFSNYPRETRLDYIKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSAIVKY 247
Cdd:COG0209 73 TPQDLFMRVAMGLAAAEKPEDREEWAKEFYDLLSSLRFLPATPTLFNAGTPRGQLSSCFVLPVEDSLESIFDALKDAALL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 248 VSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEVESLLVLKNNRGTDA 327
Cdd:COG0209 153 SKSGGGVGFNFSRLRPKGSPIKGTGGVSSGPVPFMKVFDDAAVAVNQGGKRRGANMVYLRVWHPDIEEFLDLKKNNGDER 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 328 NRVRHMDYGVQINKLMYTRLLKGGDITLFSPSDVPGLYDAFFadqDEFERLYTQYEQDDSIRKqRIKAVELFSLMMQERA 407
Cdd:COG0209 233 RRLHNFNISVWIPDLFMEAVEEDEDWTLFSPREVPDLYGLYG---EEFEEAYEEYEADGRVYK-TIKARELWRKILESAW 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 408 STGRIYIQNVDHCNTHSPFdPVVAPVRQSNLCLEIALPTKPLedvndengEIALCTLSAFNL------GVIDsLDELEEL 481
Cdd:COG0209 309 ETGEPGILFKDTINRRNPL-PHLGVIHSSNLCGEIPLLPYES--------EDASCNLGSINLakfvkdGEFD-WEKLEET 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 482 AVLAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAIE 561
Cdd:COG0209 379 VRTAVRFLDNVIDINDYPVPEIEKANRRHRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASAELAKE 458
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 562 QGACPWFNETTYAKGILPIDTYKKDldaiVSESLHYDWEQLRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGH 641
Cdd:COG0209 459 RGAFPAFEGSKYAKGILPFDKYLDD----LLIPTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIEPIFSL 534
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 642 VSIKASKD-GILRQVVPDY-------------------------------EKLQNGYELLWEMPnNDGYLQLVGIMQKFI 689
Cdd:COG0209 535 VYVRKVLDgGEFTVVNPYLvralkelglwdeelvekikedgsvqdidelpEELKELYVTAYEID-PEWHIDMQAARQKHV 613
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|...
gi 1766864855 690 DQSISANTNYDPTrfpsgkVPMQQLLKDLLNAYKFGVKTLYYHNTRDGAEDAQ 742
Cdd:COG0209 614 DQAISKTLNLPND------ATVEDLAELYLLAWKLGLKGIYYYRDGSRTGQVL 660
|
|
| NrdE_NrdA |
TIGR02506 |
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ... |
145-735 |
0e+00 |
|
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 654.45 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 145 YAAVKQLEGKYLVQNRVTGEIYESAQFLYILVAACLFSNYPRETRLDYIKRFYDAVSTFKISLPTPIMSGVRTPTRQFSS 224
Cdd:TIGR02506 1 YMGLKELYNRYLLRNAATGAIYESPQEAYMRVAMGLASLEPKDTRLADAIRFYDLLSRLKISPATPTLFNAGTPRGQLSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 225 CVLIECGDS-LDSINATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAAT 303
Cdd:TIGR02506 81 CFLLDVTDDtLESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSPIRGTNNASKGIIPFLKLLDSSVEAVNQGGKRPGAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 304 LFYPMWHLEVESLLVLKNNRGTDANRVRHMDYGVQINKLMYTRLLKGGDITLFSPSDVPGLYDAFFAdqdEFERLYTQYE 383
Cdd:TIGR02506 161 VYLEVWHPDIEEFLDLKKNNGDERRRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPYDVPGLYGLYGE---EFEEEYERLE 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 384 QDDSIRK--QRIKAVELFSLMMQERASTGRIYIQNVDHCNTHSPFDPVVAPVRQSNLCLEIALPTKPledvnDENGEIAL 461
Cdd:TIGR02506 238 KDVEARKkiRKVSARDLMKDILRTRVETGRPYILFKDAVNKHNPFKTGGGAIKMSNLCTEITQPTDD-----SHKGETAV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 462 CTLSAFNLG--VIDSLD---ELEELAVLAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSA 536
Cdd:TIGR02506 313 CNLASVNLAnfVMEDKFdfsELEDAVRIAVRFLDNVIDLQNYPTAPAAKSNQRRRSIGIGVMGLHDVLAKLGLPYDSEEA 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 537 NNLTHKTFEAIQYYLLKASNELAIEQGACPWFNETTYAKGILPIDTYKKDLDAIVS-ESLHYDWEQLRESIKTHGLRNST 615
Cdd:TIGR02506 393 RDLNDRIFEAIYYYAIKASAELAKEKGPFPGFSGSKYAKGWLHPDTWEKTIDPKTSmAPTEEDWEALRERIKEYGLRNSQ 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 616 LSALMPSETSSQISNATNGIEPPRGHVSIKASKDGILRQV--------------------------------VPDYEKLQ 663
Cdd:TIGR02506 473 LTALMPTASSSQLTGVTESIEPVFSNIFTKKTLSGEFLIPnkylmkeleelglwdadrrgdivenvgspqpiAAIPETLK 552
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1766864855 664 NGYELLWEMPNNDgYLQLVGIMQKFIDQSISANTNYDPTrfpsgkVPMQQLLKDLLNAYKFGVKTLYYHNTR 735
Cdd:TIGR02506 553 YKYKTAYELDQEA-LIDMAADRQKFVDQSISLNLFLTEE------VTAKDLLKLLLLAWKKGLKTMYYCRSR 617
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
223-732 |
0e+00 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 552.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 223 SSCVLIECGDSLDSINATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAA 302
Cdd:pfam02867 1 SSCFLLSVEDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGGKRRGAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 303 TLFYPMWHLEVESLLVLKNNRGTDANRVRHMDYGVQINKLMYTRLLKGGDITLFSPSDVPGLYDAFfadQDEFERLYTQY 382
Cdd:pfam02867 81 AVYLEVWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPREAPDLEDLY---GEEFEKEYYER 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 383 EQDDSIRKQRIKAVELFSLMMQERASTGRIYIQNVDHCNTHSPFdPVVAPVRQSNLCLEIALPTKPledvndenGEIALC 462
Cdd:pfam02867 158 EENEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQ-KHLGTIKSSNLCTEIVQPTSP--------SEIAVC 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 463 TLSAFNL-------GVIDsLDELEELAVLAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGS 535
Cdd:pfam02867 229 NLASINLakfvefgGTFD-FEKLREVVKLAVRALDNVIDINDYPVPEARRSNKRHRPIGLGVMGLADALAKLGIPYDSEE 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 536 ANNLTHKTFEAIQYYLLKASNELAIEQGACPWFNETTYAKGILPIDTYKKDLDAIVSESLHYDWEQLRESIKTHGLRNST 615
Cdd:pfam02867 308 ARDLNDKIFETMYYYALKASSELAKEKGPFPGFEGSKYSKGILQFDKYVKTDFAPKASKTREDWEELREDIKKYGLRNSQ 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 616 LSALMPSETSSQISNATNGIEPPRGHVSIKASKDgilrqvvpdyEKLQNGYELLWEMPNNDgYLQLVGIMQKFIDQSISA 695
Cdd:pfam02867 388 LTAIAPTGSISQIAGATESIEPIFSNVYSRKVLS----------EETKEYYKTAYDIDQKA-HIDMAAARQPFVDQSISK 456
|
490 500 510
....*....|....*....|....*....|....*..
gi 1766864855 696 NTNYDptrfpsGKVPMQQLLKDLLNAYKFGVKTLYYH 732
Cdd:pfam02867 457 TLFLP------NDATTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
169-734 |
1.58e-178 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 518.64 E-value: 1.58e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 169 AQFLYILVAACLFSNypretRLDYIKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSAIVKYV 248
Cdd:cd01679 1 PQDRLMRVALGLASG-----DLEWAKEFYDLLSKQRFTPATPTLFNAGTPRGQLSSCFLLTVDDSLESIYDTIKECAQLS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 249 SQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEVESLLVLKNNRGTDAN 328
Cdd:cd01679 76 KIGGGIGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGGQRKGAGAVYLEIWHPDIEEFLDLKKNNGDERR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 329 RVRHMDYGVQINKLMYTRLLKggditlfspsdvpglydaffadqdeferlytqyeqddsirkqrikavELFSLMMQERAS 408
Cdd:cd01679 156 RARDLFYGVWIPDLFMERVER-----------------------------------------------DLWRKILESQFE 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 409 TGRIYIQNVDHCNTHSPFDPvVAPVRQSNLCLEIALPTKPLEdvnDENGEIALCTLSAFNLGVIDSLDELEELAVLAVRA 488
Cdd:cd01679 189 TGYPYILFKDTCNRKNPQKH-LGTIKSSNLCTEILQPTSPSE---DEPGEDAVCNLASINLGNFVTFEKLEEVVKLAVRA 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 489 LDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAIEQGacpwf 568
Cdd:cd01679 265 LDNVIDLNYYPVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYALKASCELAKERG----- 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 569 nettyakgilpidtykkdldaivseslhydweqlresikthGLRNSTLSALMPSETSSQISNATNGIEPPRGHVSIKASK 648
Cdd:cd01679 340 -----------------------------------------GLRNSLLLAIAPTASISQILGATPSIEPITSNIYVRRVL 378
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 649 DGILRQVVPDYEKLQN--GYELLWEMPNNDGYLQLVGIMQKFIDQSISANTNYDPTrfpsgkVPMQQLLKDLLNAYKFGV 726
Cdd:cd01679 379 SGEFPVVNPHLEKDLWeyGLYKTAYEIDQRWLIDLAADRQKHIDQGQSLNLFLTPP------ATTRDLNSLYFYAWKKGL 452
|
....*...
gi 1766864855 727 KTLYYHNT 734
Cdd:cd01679 453 KTLYYLRT 460
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09103 |
PRK09103 |
ribonucleoside-diphosphate reductase subunit alpha; |
4-761 |
0e+00 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181649 [Multi-domain] Cd Length: 758 Bit Score: 1844.25 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 4 SLLVTKRDGSTERINLDKIHRVLDWAAEGLNNVSISQVELRSHIQFYDGIKTADIHETIIKAAADLISREAPDYQYLAAR 83
Cdd:PRK09103 1 SLLVTKRDGRTERINLDKIHRVITWAAEGLHNVSVSQVELRSHIQFYDGIKTSDIHETIIKAAADLISRDAPDYQYLAAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 84 LAIFHLRKKAYGQFEPPALFDHVSKMVKNGKYDTHLLEDYTEEEFKQMDSFIEHDRDMTFSYAAVKQLEGKYLVQNRVTG 163
Cdd:PRK09103 81 LAIFHLRKKAYGQFEPPALYDHVVKMVEMGKYDKHLLEDYTEEEFDQMDTFIDHWRDMNFSYAAVKQLEGKYLVQNRVTG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 164 EIYESAQFLYILVAACLFSNYPRETRLDYIKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSA 243
Cdd:PRK09103 161 EIYESAQFLYILVAACLFSNYPKETRLDYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 244 IVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEVESLLVLKNNR 323
Cdd:PRK09103 241 IVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPIWHLEVESLLVLKNNR 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 324 GTDANRVRHMDYGVQINKLMYTRLLKGGDITLFSPSDVPGLYDAFFADQDEFERLYTQYEQDDSIRKQRIKAVELFSLMM 403
Cdd:PRK09103 321 GVEENRVRHMDYGVQINKLMYQRLIKGGDITLFSPSDVPGLYDAFFADQDEFERLYTKYEQDDSIRKKRVKAVELFSLMM 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 404 QERASTGRIYIQNVDHCNTHSPFDPVVAPVRQSNLCLEIALPTKPLEDVNDENGEIALCTLSAFNLGVIDSLDELEELAV 483
Cdd:PRK09103 401 QERASTGRIYIQNVDHCNTHSPFDPKVAPVRQSNLCLEIALPTKPLNDVNDENGEIALCTLSAFNLGAINSLDELEELAD 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 484 LAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAIEQG 563
Cdd:PRK09103 481 LAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKNGVRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQG 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 564 ACPWFNETTYAKGILPIDTYKKDLDAIVSESLHYDWEQLRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGHVS 643
Cdd:PRK09103 561 ACPWFNETTYAQGILPIDTYKKDLDAICNEPLHYDWETLREEIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVS 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 644 IKASKDGILRQVVPDYEKLQNGYELLWEMPNNDGYLQLVGIMQKFIDQSISANTNYDPTRFPSGKVPMQQLLKDLLNAYK 723
Cdd:PRK09103 641 IKASKDGILKQVVPDYERLKDAYELLWEMPNNDGYLQLVGIMQKFVDQSISANTNYDPSRFPSGKVPMKQLLKDLLTAYK 720
|
730 740 750
....*....|....*....|....*....|....*...
gi 1766864855 724 FGVKTLYYHNTRDGAEDAQDDLAPSIQDDGCESGACKI 761
Cdd:PRK09103 721 FGVKTLYYHNTRDGAEDAQDDLQPSIQDDGCEGGACKI 758
|
|
| nrdA |
PHA02572 |
ribonucleoside-diphosphate reductase subunit alpha; Provisional |
2-761 |
0e+00 |
|
ribonucleoside-diphosphate reductase subunit alpha; Provisional
Pssm-ID: 222883 [Multi-domain] Cd Length: 753 Bit Score: 1263.87 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 2 NQSLLVTKRDGSTERINLDKIHRVLDWAAEGlNNVSISQVELRSHIQFYDGIKTADIHETIIKAAADLISREAPDYQYLA 81
Cdd:PHA02572 1 SMIINVIKSSGVSQPFDLEKIHKVLEWACEG-TGVDPSELEENSKIQLRDGMTTKDIQEILIKSAADLISVEEPDYQYVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 82 ARLAIFHLRKKAYGQFEPPALFDHVSKMVKNGKYDTHLLEDYTEEEFKQMDSFIEHDRDMTFSYAAVKQLEGKYLVQNRV 161
Cdd:PHA02572 80 ARLLMFALRKQVYGQFEPPSFIDHISKCVNEGKYDPEILSKYSAEEITYLESFIDHDRDFEFTYAGAMQLKEKYLVQDRS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 162 TGEIYESAQFLYILVAACLFSNYPRETRLDYIKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATS 241
Cdd:PHA02572 160 TGEIYETPQFAYMLIAMALHQDEPKEDRLEHVIRFYNAVSTRKISLPTPIMAGVRTPTRQFSSCVVIESGDSLDSINKTA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 242 SAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEVESLLVLKN 321
Cdd:PHA02572 240 MAIVKYISKRAGIGINAGMIRAEGSKIRGGEVRHTGVIPFWKHFQTAVKSCSQGGIRGGAATAYYPIWHLEVEDLLVLKN 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 322 NRGTDANRVRHMDYGVQINKLMYTRLLKGGDITLFSPSDVPG-LYDAFFADQDEFERLYTQYEQDDSIRKQRIKAVELFS 400
Cdd:PHA02572 320 NKGVEENRIRHLDYGVQINDLMYERFIKNDYITLFSPHDVGGeLYDAYFADQDRFRELYEALEKDPSVRKKRIKAQELFL 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 401 LMMQERASTGRIYIQNVDHCNTHSPFdpvVAPVRQSNLCLEIALPTKPLEDVnDENGEIALCTLSAFNLGVIDSLDELEE 480
Cdd:PHA02572 400 LLLKERSETGRIYIMFIDHCNNHSPF---KDPIRQSNLCCEIALPTKPLNHI-DGEGEIALCTLSAIVLGNFEDQDEIEE 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 481 LAVLAVRALDALLDYQDYPIPAAKRgAMGRRTLGIGVINFAYYLAKHGKRYSDgSANNLTHKTFEAIQYYLLKASNELAI 560
Cdd:PHA02572 476 LAEVAVRALDNLLDYQDYPVPAALK-AKKRRSLGVGVTNYAHYLAKNFASYED-ANADLVHELFERLQYYLIKASNKLAK 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 561 EQGACPWFNETTYAKGILPIDTYKKDLDAIVSESLHYDWEQLRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRG 640
Cdd:PHA02572 554 EKGACEYFSDTKYSRGELPIDWYKKKVDELVAPKYNCDWESLREDLKKYGIRNSTLSALMPCESSSQVSNSTNGIEPPRG 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 641 HVSIKASKDGILRQVVPDYEKLQNGYELLWEM--PNNDGYLQLVGIMQKFIDQSISANTNYDPTRFPSGKVPMQQLLKDL 718
Cdd:PHA02572 634 PVSIKKSKEGPFNQVVPNVETLKDLYDLLWDLakKGNKGYLTQVAIMQKFVDQAISANTSYDPENYPNGKVPMSVMLDDL 713
|
730 740 750 760
....*....|....*....|....*....|....*....|...
gi 1766864855 719 LNAYKFGVKTLYYHNTRDGAEDAQDDLAPSIQDDgCESgaCKI 761
Cdd:PHA02572 714 LYFYYYGGKTLYYHNTRDGKGTEDYEIETPKAED-CDS--CKL 753
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
88-742 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 689.62 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 88 HLRKKAYGQFepPALFDHVsKMVKNGKYDTHLLEdyteEEFKQMDSFIEHDRDMTFSYAAVKQLEGKYLVQNrVTGEIYE 167
Cdd:COG0209 1 QLRKEALGQY--KSFSEKI-KYVEEGLYDERLLE----EDLEELAAAIDPERDRFFSYNALKTLYDRYLLKD-EDGKPLE 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 168 SAQFLYILVAACLFSNYPRETRLDYIKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSAIVKY 247
Cdd:COG0209 73 TPQDLFMRVAMGLAAAEKPEDREEWAKEFYDLLSSLRFLPATPTLFNAGTPRGQLSSCFVLPVEDSLESIFDALKDAALL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 248 VSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEVESLLVLKNNRGTDA 327
Cdd:COG0209 153 SKSGGGVGFNFSRLRPKGSPIKGTGGVSSGPVPFMKVFDDAAVAVNQGGKRRGANMVYLRVWHPDIEEFLDLKKNNGDER 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 328 NRVRHMDYGVQINKLMYTRLLKGGDITLFSPSDVPGLYDAFFadqDEFERLYTQYEQDDSIRKqRIKAVELFSLMMQERA 407
Cdd:COG0209 233 RRLHNFNISVWIPDLFMEAVEEDEDWTLFSPREVPDLYGLYG---EEFEEAYEEYEADGRVYK-TIKARELWRKILESAW 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 408 STGRIYIQNVDHCNTHSPFdPVVAPVRQSNLCLEIALPTKPLedvndengEIALCTLSAFNL------GVIDsLDELEEL 481
Cdd:COG0209 309 ETGEPGILFKDTINRRNPL-PHLGVIHSSNLCGEIPLLPYES--------EDASCNLGSINLakfvkdGEFD-WEKLEET 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 482 AVLAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAIE 561
Cdd:COG0209 379 VRTAVRFLDNVIDINDYPVPEIEKANRRHRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASAELAKE 458
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 562 QGACPWFNETTYAKGILPIDTYKKDldaiVSESLHYDWEQLRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGH 641
Cdd:COG0209 459 RGAFPAFEGSKYAKGILPFDKYLDD----LLIPTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIEPIFSL 534
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 642 VSIKASKD-GILRQVVPDY-------------------------------EKLQNGYELLWEMPnNDGYLQLVGIMQKFI 689
Cdd:COG0209 535 VYVRKVLDgGEFTVVNPYLvralkelglwdeelvekikedgsvqdidelpEELKELYVTAYEID-PEWHIDMQAARQKHV 613
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|...
gi 1766864855 690 DQSISANTNYDPTrfpsgkVPMQQLLKDLLNAYKFGVKTLYYHNTRDGAEDAQ 742
Cdd:COG0209 614 DQAISKTLNLPND------ATVEDLAELYLLAWKLGLKGIYYYRDGSRTGQVL 660
|
|
| NrdE_NrdA |
TIGR02506 |
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ... |
145-735 |
0e+00 |
|
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 654.45 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 145 YAAVKQLEGKYLVQNRVTGEIYESAQFLYILVAACLFSNYPRETRLDYIKRFYDAVSTFKISLPTPIMSGVRTPTRQFSS 224
Cdd:TIGR02506 1 YMGLKELYNRYLLRNAATGAIYESPQEAYMRVAMGLASLEPKDTRLADAIRFYDLLSRLKISPATPTLFNAGTPRGQLSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 225 CVLIECGDS-LDSINATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAAT 303
Cdd:TIGR02506 81 CFLLDVTDDtLESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSPIRGTNNASKGIIPFLKLLDSSVEAVNQGGKRPGAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 304 LFYPMWHLEVESLLVLKNNRGTDANRVRHMDYGVQINKLMYTRLLKGGDITLFSPSDVPGLYDAFFAdqdEFERLYTQYE 383
Cdd:TIGR02506 161 VYLEVWHPDIEEFLDLKKNNGDERRRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPYDVPGLYGLYGE---EFEEEYERLE 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 384 QDDSIRK--QRIKAVELFSLMMQERASTGRIYIQNVDHCNTHSPFDPVVAPVRQSNLCLEIALPTKPledvnDENGEIAL 461
Cdd:TIGR02506 238 KDVEARKkiRKVSARDLMKDILRTRVETGRPYILFKDAVNKHNPFKTGGGAIKMSNLCTEITQPTDD-----SHKGETAV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 462 CTLSAFNLG--VIDSLD---ELEELAVLAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSA 536
Cdd:TIGR02506 313 CNLASVNLAnfVMEDKFdfsELEDAVRIAVRFLDNVIDLQNYPTAPAAKSNQRRRSIGIGVMGLHDVLAKLGLPYDSEEA 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 537 NNLTHKTFEAIQYYLLKASNELAIEQGACPWFNETTYAKGILPIDTYKKDLDAIVS-ESLHYDWEQLRESIKTHGLRNST 615
Cdd:TIGR02506 393 RDLNDRIFEAIYYYAIKASAELAKEKGPFPGFSGSKYAKGWLHPDTWEKTIDPKTSmAPTEEDWEALRERIKEYGLRNSQ 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 616 LSALMPSETSSQISNATNGIEPPRGHVSIKASKDGILRQV--------------------------------VPDYEKLQ 663
Cdd:TIGR02506 473 LTALMPTASSSQLTGVTESIEPVFSNIFTKKTLSGEFLIPnkylmkeleelglwdadrrgdivenvgspqpiAAIPETLK 552
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1766864855 664 NGYELLWEMPNNDgYLQLVGIMQKFIDQSISANTNYDPTrfpsgkVPMQQLLKDLLNAYKFGVKTLYYHNTR 735
Cdd:TIGR02506 553 YKYKTAYELDQEA-LIDMAADRQKFVDQSISLNLFLTEE------VTAKDLLKLLLLAWKKGLKTMYYCRSR 617
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
223-732 |
0e+00 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 552.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 223 SSCVLIECGDSLDSINATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAA 302
Cdd:pfam02867 1 SSCFLLSVEDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGGKRRGAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 303 TLFYPMWHLEVESLLVLKNNRGTDANRVRHMDYGVQINKLMYTRLLKGGDITLFSPSDVPGLYDAFfadQDEFERLYTQY 382
Cdd:pfam02867 81 AVYLEVWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPREAPDLEDLY---GEEFEKEYYER 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 383 EQDDSIRKQRIKAVELFSLMMQERASTGRIYIQNVDHCNTHSPFdPVVAPVRQSNLCLEIALPTKPledvndenGEIALC 462
Cdd:pfam02867 158 EENEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQ-KHLGTIKSSNLCTEIVQPTSP--------SEIAVC 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 463 TLSAFNL-------GVIDsLDELEELAVLAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGS 535
Cdd:pfam02867 229 NLASINLakfvefgGTFD-FEKLREVVKLAVRALDNVIDINDYPVPEARRSNKRHRPIGLGVMGLADALAKLGIPYDSEE 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 536 ANNLTHKTFEAIQYYLLKASNELAIEQGACPWFNETTYAKGILPIDTYKKDLDAIVSESLHYDWEQLRESIKTHGLRNST 615
Cdd:pfam02867 308 ARDLNDKIFETMYYYALKASSELAKEKGPFPGFEGSKYSKGILQFDKYVKTDFAPKASKTREDWEELREDIKKYGLRNSQ 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 616 LSALMPSETSSQISNATNGIEPPRGHVSIKASKDgilrqvvpdyEKLQNGYELLWEMPNNDgYLQLVGIMQKFIDQSISA 695
Cdd:pfam02867 388 LTAIAPTGSISQIAGATESIEPIFSNVYSRKVLS----------EETKEYYKTAYDIDQKA-HIDMAAARQPFVDQSISK 456
|
490 500 510
....*....|....*....|....*....|....*..
gi 1766864855 696 NTNYDptrfpsGKVPMQQLLKDLLNAYKFGVKTLYYH 732
Cdd:pfam02867 457 TLFLP------NDATTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
169-734 |
1.58e-178 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 518.64 E-value: 1.58e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 169 AQFLYILVAACLFSNypretRLDYIKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSAIVKYV 248
Cdd:cd01679 1 PQDRLMRVALGLASG-----DLEWAKEFYDLLSKQRFTPATPTLFNAGTPRGQLSSCFLLTVDDSLESIYDTIKECAQLS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 249 SQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEVESLLVLKNNRGTDAN 328
Cdd:cd01679 76 KIGGGIGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGGQRKGAGAVYLEIWHPDIEEFLDLKKNNGDERR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 329 RVRHMDYGVQINKLMYTRLLKggditlfspsdvpglydaffadqdeferlytqyeqddsirkqrikavELFSLMMQERAS 408
Cdd:cd01679 156 RARDLFYGVWIPDLFMERVER-----------------------------------------------DLWRKILESQFE 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 409 TGRIYIQNVDHCNTHSPFDPvVAPVRQSNLCLEIALPTKPLEdvnDENGEIALCTLSAFNLGVIDSLDELEELAVLAVRA 488
Cdd:cd01679 189 TGYPYILFKDTCNRKNPQKH-LGTIKSSNLCTEILQPTSPSE---DEPGEDAVCNLASINLGNFVTFEKLEEVVKLAVRA 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 489 LDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAIEQGacpwf 568
Cdd:cd01679 265 LDNVIDLNYYPVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYALKASCELAKERG----- 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 569 nettyakgilpidtykkdldaivseslhydweqlresikthGLRNSTLSALMPSETSSQISNATNGIEPPRGHVSIKASK 648
Cdd:cd01679 340 -----------------------------------------GLRNSLLLAIAPTASISQILGATPSIEPITSNIYVRRVL 378
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 649 DGILRQVVPDYEKLQN--GYELLWEMPNNDGYLQLVGIMQKFIDQSISANTNYDPTrfpsgkVPMQQLLKDLLNAYKFGV 726
Cdd:cd01679 379 SGEFPVVNPHLEKDLWeyGLYKTAYEIDQRWLIDLAADRQKHIDQGQSLNLFLTPP------ATTRDLNSLYFYAWKKGL 452
|
....*...
gi 1766864855 727 KTLYYHNT 734
Cdd:cd01679 453 KTLYYLRT 460
|
|
| PRK07088 |
PRK07088 |
ribonucleoside-diphosphate reductase subunit alpha; |
4-731 |
1.78e-111 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180831 [Multi-domain] Cd Length: 764 Bit Score: 356.04 E-value: 1.78e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 4 SLLVTKRDGSTERINLDKIHRVLDWAAEGLNNVSISQVELRSHIQFYDGIKTADIHETIIKAAADL------------IS 71
Cdd:PRK07088 2 NIKIKKRDGQYEPLQVEKTKKMVKLACEGLYGCDPLELELDSRIQFRDGMTTKEIQKSLIQTAIEKviqnskdnngnnTK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 72 REAPDYQYLAARLAIFHLRKKA-----YGQFEPPALFDHVSKMVKNGKYDTHLLEDYTEEEFKQMDSFIEHDRDMTFSYA 146
Cdd:PRK07088 82 KTNPNWQYVAARLYVFDLYKEArinrhYNSFGYGDYYELVKKLVEEKLYGEYLLQNYSKEEIKELEKYIKPERDFLFNYE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 147 AVKQLEGKYLVQNrVTGEIYESAQFLYILVAACLFSNYPRETRLDYIKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCV 226
Cdd:PRK07088 162 GLKLLADRYLVKG-FNREILELPQERFMGIAMHLAIPEGKEKRVYYAKKFYDLLSELKATVATPTLSNAGTPFYQLSSCF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 227 LIECGDSLDSINATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFY 306
Cdd:PRK07088 241 ISVVDDNLWSIYDVNQKFAQVSKHGGALGIYTGKIRALNSEIRGFKNASGGVIPWIKLYNDTAIAVDQLGKRKGGAAITL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 307 PMWHLEVESLLVLKNNRGTDANRVRHMDYGVQINKLMYTRLLKGGDITLFSPSDVPGL----YDAFFADQD--EFERLYT 380
Cdd:PRK07088 321 DIWHKDIPEFLDLKTNNGDDRRKAHDIFPGVSYPDLFMKRLEKRENWSLFDPHEIKKVkgysLEDYYDEEDrkEFTKKYL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 381 QYEQDDSIRKQRIKAVELFSLMMQERASTGRIYIQNVDHCNTHSPfDPVVAPVRQSNLCLEIAL---PTKPLED-VNDEN 456
Cdd:PRK07088 401 ECEEDTNIPRRTVPVLDIMKKIMKSAVETGTPFIFFRDTVNKANP-NKHKGMIYSSNLCHEIAQnmsESELLEEeIIDEN 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 457 GEIAL-----------CTLSAFNLGVIDSlDELEELAVLAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLA 525
Cdd:PRK07088 480 GYYEVvqkikagdmvtCNLNSIVLGNVDD-EELEEVIPTQIRMLDNVISLNYYPVPEAEITSDKYRAIGLGTSGYHHMLA 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 526 KHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAIEQGACPWFNETTYAKGilpidTYKKdLDAIVSESlhydWEQLRES 605
Cdd:PRK07088 559 NNKIRWESDEHIKFADKIYEEIAYYAIKASMELAKEKGSYPAFKGSEWETG-----KYFE-RRGYNSER----WKKLKEE 628
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 606 IKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGHVSIKASKDGILRQVVPD-------YEKLQNGYELLWEMPNNdgy 678
Cdd:PRK07088 629 IKKYGMRNGYITAVAPTGSTSNIANTTAGIDPVFKRFFMEEKKGSFTPKTAPDlneenfwYYKEAHTIDQQWSIKAC--- 705
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|...
gi 1766864855 679 lqlvGIMQKFIDQSISANTNYDPtrfpsgKVPMQQLLKDLLNAYKFGVKTLYY 731
Cdd:PRK07088 706 ----GVRQRHIDQAQSFNLYITP------EYKAKQILNLYIEAWKQGVKTIYY 748
|
|
| PRK08447 |
PRK08447 |
ribonucleoside-diphosphate reductase subunit alpha; |
5-755 |
1.08e-107 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236266 [Multi-domain] Cd Length: 789 Bit Score: 346.71 E-value: 1.08e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 5 LLVTKRDGSTERINLDKIHRVLDWAAEGLNNVSISQVELRSHIQFYDGIKTADIHETIIKAAADLISREAPDYQYLAARL 84
Cdd:PRK08447 2 ITVVKRNGRIEPLDISKIQKYTSDAVEGLEGVSQSELEVDAKIQFRDGITTEEIQQTLIKTAVDKIDIDRPNWTFVAARL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 85 AIFHLRKKAYGQFEPPALFDHVSKMVKNGKYDTHLLEDYTEEEfkqMDSFIEHDRDMTFSYAAVKQLEGKYLVQNRvTGE 164
Cdd:PRK08447 82 FLYDLYHKVSGFTGYNHLKEYFEKGEKEGRILLGLKEKYDLDD---LNAYIKPERDLQFNYLGIKTLYDRYLIKDR-NNN 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 165 IYESAQFLYILVAACLFSNypRETRLDYIKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSAI 244
Cdd:PRK08447 158 PIELPQHMFMAIAMFLAQN--ELDPQKWAKKFYDVISKFEVMLATPTLSNARTTRHQLSSCYIGSTPDNIEGIFDSYKEM 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 245 VKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEVESLLVLKNNRG 324
Cdd:PRK08447 236 ALLSKYGGGIGWDWSKVRAMGSYIDGHKNAAGGIIPFLKITNDIAIAVDQLGTRKGAIAVYLEPWHMDISDFIDLRKNSG 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 325 TDANRVRHMDYGVQINKLMYTRLLKGGDITLFSPSDVPGLYDAFfadQDEFERLYTQYEQDDSIRKQRIKAVELFSLMMQ 404
Cdd:PRK08447 316 EERRRAHDLFPALWINDLFMKRVEEDAMWTLFDPYECKDLTELY---GEEFEKRYLEYEKDEKIIKEYINAKELWKKILT 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 405 ERASTGRIYIQNVDHCNTHSPfDPVVAPVRQSNLCLEIALPTKP--------LEDVNDE--------------------- 455
Cdd:PRK08447 393 NYFETGLPFLCFKDNANRANP-NAHAGIIRSSNLCTEIFQNTAPnhykikieFEDGSIEffeeeelvtvdsgitkkakki 471
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 456 -------------------NGEIALCTLSAFNLGVIDSLDELEELAVLAVRALDALLDYQDYPIPAAKRGAMGRRTLGIG 516
Cdd:PRK08447 472 tsldslkgkkiyivekekkDGKTAVCNLASINLSKINTKEDIERVVPIAIRMLDNVIDLNFYPNRKVKATNLKSRAIGLG 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 517 VINFAYYLAKHGKRYsdGSANNLTH--KTFEAIQYYLLKASNELAIEQGACPWFNETTYAKGILPIDTYKKDLDAIVSE- 593
Cdd:PRK08447 552 VMGEAQMLAEHKIAW--GSKEHLEKidEIMEQISYNAIDASSNLALEKGVYPDFEGSNWSKGIFPIDKANEEAKKLVERg 629
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 594 ---SLHYDWEQLRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGHVSIKASKDGILRQVVPD-----YEKLQNG 665
Cdd:PRK08447 630 glfDSACDWEGLREKVKKDGMRNGYLMAIAPTSSISILVGTTQTIEPVYKRKWFEENLSGLIPVVVPNlspetWQYYTPA 709
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 666 YELlwempNNDGYLQLVGIMQKFIDQSISANTnYDPTRFPSGKVpmqqlLKDL-LNAYKFGVKTLYYhnTRDGAEDAQDD 744
Cdd:PRK08447 710 YDL-----DQKDLIKAAAVRQKWIDQGQSLNI-FLSLDKASGKY-----LNEIyTLAWKLGLKSTYY--LRSESPESEEV 776
|
810
....*....|...
gi 1766864855 745 LAP--SIQDDGCE 755
Cdd:PRK08447 777 SVAdrSIECEGCQ 789
|
|
| PRK12364 |
PRK12364 |
ribonucleoside-diphosphate reductase subunit alpha; |
62-731 |
9.91e-96 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 237077 [Multi-domain] Cd Length: 842 Bit Score: 316.31 E-value: 9.91e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 62 IIKAAADLISREAPDYQYLAARLAIFHLRKKAYGQFEPPALFDHVSK---MVKNGKYDTHLLEDYTEEEFKQMDSFIEHD 138
Cdd:PRK12364 152 LIKAAVELTTQEAPDWEFIAARLLMLQFSKKLGKSLEKLGIHSFYDKikyLTEEGLYGSYILEHYSREEIEEAAGFIDPE 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 139 RDMTFSYAAVKQLEGKYLVQNRvTGEIYESAQFLYILVAACLFSNyPRETRLDYIKRFYDAVSTFKISLPTPIMSGVRTP 218
Cdd:PRK12364 232 RDKLFTYSGLDLLLKRYVIRTH-SHEPLESPQEMFLGIALHLAMP-EKQDRMGWVKRFYDMLSKLKVTMATPTLSNARKP 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 219 TRQFSSCVLIECGDSLDSINATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQ-TAVkSCSQGGV 297
Cdd:PRK12364 310 FHQLSSCFIDTVPDSLDGIYRSIDNFAQVSKFGGGMGLYFGKVRAVGSNIRGFQGVAGGVIRWIKLANdTAV-AVDQLGM 388
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 298 RGGAATLFYPMWHLEVESLLVLKNNRGTDanRVRHMDY--GVQINKLMYtRLLK---GGDITLFSPSDVPGLYDAFFAD- 371
Cdd:PRK12364 389 RQGAVAVYLDVWHKDIPEFLQLRTNNGDD--RMKAHDVfpAVCYPDLFW-KMVRddiNQSWYLFCPHEILTVKGYALEDy 465
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 372 -QDEFERLYTQYEQDDSIRKQRIKAVELFSLMMQERASTGRIYIQNVDHCNTHSPfDPVVAPVRQSNLCLEIALPTKPLE 450
Cdd:PRK12364 466 yGEEWEKRYLDCVNDARISKRSIPIKDLVRLILKSAVETGTPFTFNRDTVNRANP-NKHKGMIYCSNLCTEIAQNMSAIE 544
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 451 DVN----DENGE-----------IALCTLSAFNLGVIDSLD--ELEELAVLAVRALDALLDYQDYPIPAAKRGAMGRRTL 513
Cdd:PRK12364 545 TVSteieTEDGDtvvvtttrpgdFVVCNLASLSLGNIDLEDeeELEEVVRTVVRALDNVIDLNFYPVPYAQITNKRYRSI 624
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 514 GIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAIEQGACPWFNETTYAKGilpidTYKKDLDaIVSE 593
Cdd:PRK12364 625 GLGVSGYHHALAKNGIRWESEEHLEFADRVFERINYAAIKASMEIAKEKGAYGYFEGSDWQTG-----AYFRKRG-YTSE 698
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 594 slhyDWEQLRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGHVSIKASKDGILRQVVPD-----YEKLQNGYEL 668
Cdd:PRK12364 699 ----EWQRLAREVAENGMRNAYLLAVAPTSSTSIIAGTTAGVDPVMKRYFLEEKKGALMPRVAPElsdktFWLYKNAHLI 774
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1766864855 669 --LWEMpnndgylQLVGIMQKFIDQSISANTnYDPTRFpsgkvPMQQLLKDLLNAYKFGVKTLYY 731
Cdd:PRK12364 775 dqKWSI-------RAAGVRQRHIDQAQSVNL-YITNEF-----TMRQVLDLYLLAWEEGVKTIYY 826
|
|
| PRK12365 |
PRK12365 |
ribonucleoside-diphosphate reductase subunit alpha; |
7-731 |
4.41e-90 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 171440 [Multi-domain] Cd Length: 1046 Bit Score: 304.95 E-value: 4.41e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 7 VTKRDGSTERINLDKIHRVLDWAAEGLNNVSISQVEL-RSHIQFYDGIKTADIHETIIKAAADLISREaPDYQYLAARLA 85
Cdd:PRK12365 238 VLSKDGSTYTMTKSQLLAHFAWACSRFPETTDAALLAdMAFANFYSGIKESEVVLACIMAARANIEKE-PDYAFVAAELL 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 86 IFHLRKKAYGQFE-----PPALFDHVSKMVKNGkyDTHLLEDYTEE-EFKQMDSFIEHDRDMTFSYAAVKQLEGKYLvqN 159
Cdd:PRK12365 317 LDVVYKEALGKSKydedlEEAHKDHFKRYILEG--DTYRLNPELKHyDLDALAEALDLSRDLQFSYMGVQNLYDRYF--N 392
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 160 RVTGEIYESAQFLYILVAACLFSNyPRETRLDYIKRFYDAVSTFKISLPTPIM--SGVRTptRQFSSCVLIECGDSLdsi 237
Cdd:PRK12365 393 HHEGRRLETPQIFWMRVSMGLALN-EGQDKTSWAITFYNLLSTFRYTPATPTLfnSGMRH--SQLSSCYLSTVQDDL--- 466
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 238 natsSAIVKYVSQRA-------GIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWH 310
Cdd:PRK12365 467 ----VHIYKVISDNAmlskwagGIGNDWTAVRATGALIKGTNGKSQGVIPFIKVANDTAVAVNQGGKRKGAVCVYLEVWH 542
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 311 LEVESLLVLKNNRGTDANRVRHMDYGVQINKLMYTRLLKGGDITLFSPSDVPGLYDAFfadQDEFERLYTQYEQD-DS-- 387
Cdd:PRK12365 543 LDYEDFLELRKNTGDERRRTHDINTASWIPDLFFKRLQQKGTWTLFSPDDVPGLHEAY---GEEFEKLYEEYERKvDTge 619
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 388 IR-KQRIKAVELFSLMMQERASTGRIYIQNVDHCNTHSPFDPvVAPVRQSNLCLEIALptkpledvNDENGEIALCTLSA 466
Cdd:PRK12365 620 IRlYKKVEAEDLWRKMLSMLYETGHPWMTFKDPSNIRSAQDH-KGVVRCSNLCTEILL--------NCSETETAVCNLGS 690
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 467 FNLG---VIDSLDE--LEELAVLAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTH 541
Cdd:PRK12365 691 INLVehiVNDGLDEekLSETISIAIRILDNVIDINFYPTKEAKEANLAHRAIGLGVMGFQDALYKLNISYASQEAVEFAD 770
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 542 KTFEAIQYYLLKASNELAIEQGACPWFNETTYAKGILPIDT------YKKDLDAIVSESLHYDWEQLRESIKTHGLRNST 615
Cdd:PRK12365 771 YSSELIAYYAILASSLLAKERGTYSSYKGSKWDRGYLPIDTiellkeYRGEANLLMDTSSRKDWEPVRSLIKEYGMRNSQ 850
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 616 LSALMPSETSSQISNATNGIEPPRGHVSIKASKDGILrqVVPDYEKLQNGYEL-LWE-------------------MPNN 675
Cdd:PRK12365 851 LMAIAPTATISNIIGVTQSIEPTYKHLFVKSNLSGEF--TIPNVYLIEKLKKLgIWDadmlddlkyfdgslleierIPDH 928
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1766864855 676 DGYLQLVGI-------------MQKFIDQSISANTNYDPtrfPSGKvpmqQLLKDLLNAYKFGVKTLYY 731
Cdd:PRK12365 929 LKKIFLTAFeiepewiiecasrRQKWIDMGQSLNLYLAE---PDGK----KLSNMYLTAWKKGLKTTYY 990
|
|
| PRK09209 |
PRK09209 |
ribonucleoside-diphosphate reductase subunit alpha; |
18-731 |
4.55e-90 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181700 [Multi-domain] Cd Length: 761 Bit Score: 298.95 E-value: 4.55e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 18 NLDKIHRVLDWAAEGLNNVSISQVElRSHIQFYDGIKTA---DIHETIIKAAADLISREAPDYQYLAARLAIFHLRKKA- 93
Cdd:PRK09209 23 DKERLDRYIDQIHAEFPQLDVEDYK-RRVFNFVERKESVtadDLVDYLIREAEARVDLEEPEWTFFAARLYLNRLYKRAs 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 94 ----------YGQFepPALfdhVSKMVKNGKYDTHLLEDYTEEEFKQMDSFIEHDRDMTFSYAAVKQLEGKYLVQNRVtG 163
Cdd:PRK09209 102 rnrfydasekYGSF--VGL---QESLAERGIYSNDLLKRYSKEELIEAGKMIDPERDKLFTYIGLYLLADRYLATDSD-R 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 164 EIYESAQFLYILVAACLFSNYPRETRLDYIKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSA 243
Cdd:PRK09209 176 NVYELPQERWLTIALYLMQNEPRERRMQLVKEAYWALSNLYMTVATPTLANAGKVGGQLSSCFIDTVDDSLQGIYDSNTD 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 244 IVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQ-TAVkSCSQGGVRGGAATLFYPMWHLEVESLLVLKNN 322
Cdd:PRK09209 256 VARVSKHGGGVGAYLGKVRSRGSDIRGFKGVSSGVIPWIKQLNnTAV-SVDQLGQRKGAIAVYLDVWHKDIESFLDLRLN 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 323 RGTDANRVRHMDYGVQINKLMYTRLLKGGDITLFSPSDVP-----GLYDaFFADQD---EFERLYTQYEQDDSIRKQRIK 394
Cdd:PRK09209 335 NGDERLRAHDVFTGVCIPDLFMEAVERRGDWYLFDPHEVKkvmgwYLED-FYDEKKgdgSFREKYEECVADERLSRKTVK 413
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 395 AVELFSLMMQERASTGRIYIQNVDHCNTHSPfDPVVAPVRQSNLCLEIAL---PTKPLEDVNDEN--------GEIALCT 463
Cdd:PRK09209 414 AIDIMKRIMVSQLETGNPFMFYRDEVNRMNP-NKHEGMIYSSNLCTEIMQnmsPTVMIQEIISGGqivitkqpGDFVVCN 492
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 464 LSAFNLGVIDSLDELEELAVLAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKT 543
Cdd:PRK09209 493 LSSINLGRAVTADVLERLIPIQVRMLDNVIDLNQLPVPQATITNQKYRAIGLGTFGWHHLLALKGIAWESEEAVQYADEL 572
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 544 FEAIQYYLLKASNELAIEQGACPWFNETTYAKGilpidTYkkdldaivSESLHY---DWEQLRESIKTHGLRNSTLSALM 620
Cdd:PRK09209 573 YERINYLTIQASMELAKEKGAYPVFKGSDWQTG-----EY--------FERRGYnspQWDELAAQVAENGVRNAYLMAVA 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 621 PSETSSQISNATNGIEPPRGHVSIKASKDGILRQVVPD--------YEKlqNGYEL--LWEMPNNdgylqlvGIMQKFID 690
Cdd:PRK09209 640 PNMSTAQIAGSTASIDPIYSAFYYEEKKDYRRPVTAPDlsldtwpyYEK--GAYKVdqFWSIRQN-------AARQRHVD 710
|
730 740 750 760
....*....|....*....|....*....|....*....|.
gi 1766864855 691 QSISANTNYDPTrfpsgkVPMQQLLKDLLNAYKFGVKTLYY 731
Cdd:PRK09209 711 QSISFNFYVPST------IRASELLDLHMTAWKEGLKTTYY 745
|
|
| PRK07207 |
PRK07207 |
ribonucleoside-diphosphate reductase subunit alpha; |
4-731 |
8.86e-90 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 235966 [Multi-domain] Cd Length: 965 Bit Score: 302.65 E-value: 8.86e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 4 SLLVTKRDGSTERINLDKIHRVLDWAAEGLNNVSISQVELRSHIQFYDGIKTADIHETIIKAAADLISREaPDYQYLAAR 83
Cdd:PRK07207 148 GLNVTLDDGVRRPLDMARLRALIEEACEGLEAVDAEPILAETLKNLYDGVPMDEVYKALILAARTLIEKE-PNYSYVTAR 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 84 LAIFHLRKKAYGQFEPPALFDHVSKMVKNGKY---------DTHLLEdyteEEFKQMD-----SFIEHDRDMTFSYAAVK 149
Cdd:PRK07207 227 LLLDTLRREALGFLGVPEEVTQAEMATRYAEYfpafikkgiEAELLD----PKLAQFDlerlgAALDPERDLQFTYLGLQ 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 150 QLEGKYLVqnRVTGEIYESAQFLYILVAACLFSNYP-RETRLdyIKrFYDAVSTFKI--SLPTPIMSGVRTPtrQFSSCV 226
Cdd:PRK07207 303 TLYDRYFL--HVDGTRIELPQAFFMRVAMGLALNEIdREARA--IE-FYNLLSSFDFmsSTPTLFNSGTLRP--QLSSCY 375
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 227 LIECGDSLDSI------NATSSaivKYVsqrAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQ-TAVkSCSQGGVRG 299
Cdd:PRK07207 376 LTTVPDDLDGIyeaikdNALLS---KFA---GGLGNDWTPVRALGSHIKGTNGKSQGVVPFLKVVNdTAV-AVNQGGKRK 448
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 300 GAATLFYPMWHLEVESLLVLKNNRGTDANRVRHMDYGVQINKLMYTRLLKGGDITLFSPSDVPGLYDAFFAdqdEFERLY 379
Cdd:PRK07207 449 GAVCAYLETWHLDIEEFLELRKNTGDDRRRTHDMNTANWIPDLFMKRVMEDGEWTLFSPSEVPDLHDLFGK---AFEEAY 525
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 380 TQYEQ---DDSIRK-QRIKAVELFSLMMQERASTGRIYIQNVDHCNTHSPfDPVVAPVRQSNLCLEIALPTkpledvNDE 455
Cdd:PRK07207 526 TAYEAkaaRGEIKLfKKIPAVDLWRKMLSMLFETGHPWITFKDPCNLRSP-QQHVGVVHSSNLCTEITLNT------SDD 598
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 456 ngEIALCTLSAFNL-------GVIDsLDELEELAVLAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHG 528
Cdd:PRK07207 599 --EIAVCNLGSVNLvahikdgAKLD-HEKLKRTVSTAMRMLDNVIDINYYAVPKARNSNLRHRPVGLGIMGFQDALYLLR 675
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 529 KRYSDGSANNLTHKTFEAIQYYLLKASNELAIEQGACPWFNETTYAKGILPIDTYK-------KDLDAIVSESLhyDWEQ 601
Cdd:PRK07207 676 IPYASDEAVEFADRSMEAVSYYAIWASTELAEERGRYSSYEGSLWSRGILPIDSLKllaeargGYLEVDRSSTL--DWDA 753
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 602 LRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGHVSIKASKDG----ILRQVVPDYEKLQngyelLWE--MPNN 675
Cdd:PRK07207 754 LRARIKKHGMRNSNCMAIAPTATISNIIGVSQSIEPTYQNLYVKSNLSGeftvVNPYLVRDLKARG-----LWDevMVND 828
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 676 ----DGYLQ-----------------------LVGIM---QKFIDQSISANTnYDPTrfPSGKvPMQQLLKdllNAYKFG 725
Cdd:PRK07207 829 lkyfDGSLQridripadlkalyatafevdprwLVEAAsrrQKWIDQAQSLNL-YMAG--ASGK-KLDETYK---LAWLRG 901
|
....*.
gi 1766864855 726 VKTLYY 731
Cdd:PRK07207 902 LKTTYY 907
|
|
| PLN02437 |
PLN02437 |
ribonucleoside--diphosphate reductase large subunit |
7-741 |
5.77e-88 |
|
ribonucleoside--diphosphate reductase large subunit
Pssm-ID: 178056 [Multi-domain] Cd Length: 813 Bit Score: 294.73 E-value: 5.77e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 7 VTKRDGSTERINLDKIHRVLDWAAEGLNNVSISQVELRSHI--QFYDGIKTADIHETIIKAAADLISREaPDYQYLAARL 84
Cdd:PLN02437 3 VVKRDGRQETVHFDKITARLKKLSYGLSQDHCDPVLVAQKVcaGVYKGVTTSQLDELAAETAAAMTTNH-PDYAILAARI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 85 AIFHLRKKAYGQFEPP--ALFDHVSKmvKNGKYDTHLLEDYTE---EEFKQMDSFIEHDRDMTFSYAAVKQLEGKYLVqn 159
Cdd:PLN02437 82 AVSNLHKNTKKSFSETvkDMYNHVNE--RSGLKAPLIADDVYDiimKNAARLDSEIIYDRDFDYDYFGFKTLERSYLL-- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 160 RVTGEIYESAQFLYILVAACLfsnypRETRLDYIKRFYDAVST--FKISLPTPIMSGvrTPTRQFSSCVLIeC--GDSLD 235
Cdd:PLN02437 158 KVNGKVVERPQHMLMRVSVGI-----HKDDIESAIKTYHLMSQrwFTHASPTLFNAG--TPRPQLSSCFLI-CmkDDSIE 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 236 SINAT---SSAIVKYVsqrAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGG-VRGGAATLFYPMWHL 311
Cdd:PLN02437 230 GIYDTlkeCAVISKSA---GGIGLSVHNIRATGSYIRGTNGTSNGIVPMLRVFNDTARYVDQGGgKRKGAFAIYLEPWHA 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 312 EVESLLVLKNNRGTDANRVRHMDYGVQINKLMYTRLLKGGDITLFSPSDVPGLYDAFfadQDEFERLYTQYEQDDSIRKQ 391
Cdd:PLN02437 307 DIFEFLDLRKNHGKEEHRARDLFYALWIPDLFMERVQSNGDWSLFCPNEAPGLADCW---GEEFERLYTKYEREGKAKKV 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 392 rIKAVELFSLMMQERASTGRIYIQNVDHCNTHSPfDPVVAPVRQSNLCLEIALPTKPledvndenGEIALCTLSAFNL-- 469
Cdd:PLN02437 384 -VQAQQLWFAILESQIETGTPYMLFKDSCNRKSN-QQNLGTIKSSNLCTEIIEYTSP--------TETAVCNLASIALpr 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 470 --------------GVIDSL---------DELEELAVLAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAK 526
Cdd:PLN02437 454 fvrekgvpleshpsKLVGSLgsknryfdfEKLAEVTAVVTRNLNKIIDVNYYPVETARRSNMRHRPIGIGVQGLADAFIL 533
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 527 HGKRYSDGSANNLTHKTFEAIQYYLLKASNELAIEQGACPWFNETTYAKGILPIDTYKkdldaiVSESLHYDWEQLRESI 606
Cdd:PLN02437 534 LGMPFDSPEAQQLNKDIFETIYYHALKASSELAAREGPYETYAGSPVSKGILQPDMWG------VTPSGRWDWAALREMI 607
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 607 KTHGLRNSTLSALMPSETSSQI-----------SN----------------------ATNGIEPPRGHVSIKAsKDGILR 653
Cdd:PLN02437 608 SKNGVRNSLLVAPMPTASTSQIlgnnecfepytSNiysrrvlsgefvvvnkhllhdlTEMGLWTPTLKNKIIA-ENGSVQ 686
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 654 QV--VPDyeKLQNGYELLWEMPNNDgylqLVGiMQ----KFIDQSISANTNYD-PTrfpSGKvpmqqlLKDL-LNAYKFG 725
Cdd:PLN02437 687 KIpeIPD--DLKAIYKTVWEIKQRT----LVD-MAadrgCYIDQSQSLNIHMDqPN---FGK------LTSLhFYAWSKG 750
|
810
....*....|....*..
gi 1766864855 726 VKT-LYYHNTRdGAEDA 741
Cdd:PLN02437 751 LKTgMYYLRSR-AAADA 766
|
|
| RNR_PFL |
cd00576 |
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and ... |
193-732 |
5.68e-79 |
|
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and pyruvate formate lyase (PFL) are believed to have diverged from a common ancestor. They have a structurally similar ten-stranded alpha-beta barrel domain that hosts the active site, and are radical enzymes. RNRs are found in all organisms and provide the only mechanism by which nucleotides are converted to deoxynucleotides. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs use a diiron-tyrosyl radical while Class II RNRs use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. PFL, an essential enzyme in anaerobic bacteria, catalyzes the conversion of pyruvate and CoA to acteylCoA and formate in a mechanism that uses a glycyl radical.
Pssm-ID: 153083 [Multi-domain] Cd Length: 401 Bit Score: 259.00 E-value: 5.68e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 193 IKRFYDAVSTFKISLPTPimsgvrtpTRQFSSCVLIECGDSLD---------------SINATSSAIVKYVSQR--AGIG 255
Cdd:cd00576 1 AERIYEAVKSGVITVGRP--------DLPFTGCVLVDYGDSLDpgikgvnetaksineAIQKTYQIIALAASNQngGGVS 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 256 INA--GRIRALGSPIRG-GEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLE-----VESLLVLKNNRGTDA 327
Cdd:cd00576 73 FARasSILSPYGSRDYAkGSGTETDAVEAADAFNLALKEVGQGNGRTGAATGFIGGVHKGkgdkiSQEFLNLALANGGEG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 328 NRVRHMDYGVQINKLMYTRLlkggditlfspsdvpglydaffadqdeferlytqyeqddsirkqrIKAVELFSLMMQERA 407
Cdd:cd00576 153 IPLNFPNLSVRVSSDKPGIL---------------------------------------------VKAVELKQLIAEEAR 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 408 STGRIYIQNVDHCNtHSPFDPvvapvrqsnlcleialptkpledvndenGEIAlctLSAFNLGVIDSLDELEELAVLAVR 487
Cdd:cd00576 188 KTGSPGIFNDELCN-LVSLNL----------------------------ARIM---EKAINGSMDVVLEELEELAFLAVR 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 488 ALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYS-DGSANNLTHKTFEAIQYYLLKASNElaieqgacp 566
Cdd:cd00576 236 ALDCVIDSHDERIPTIELGGDERRTVGLGIAGVADLLIKLGLEKVgDPEADDLAAELVDQLKKHLVKATNE--------- 306
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 567 wfnettyakgilpidtykkdldaivseslhydweqlresikthgLRNSTLSALMPSETSSQISNATNGIEPPRGHVSIka 646
Cdd:cd00576 307 --------------------------------------------RGFNFLLGLSPSESNSSGAPATNGVSPSRG*IAI-- 340
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 647 skdgilrqvvpdyeklqngyeLLWEMPNNDGYLQLVGIMQKFIDQSISANTNYDPTRFpsgkvPMQQLLKDLLNAYKFGV 726
Cdd:cd00576 341 ---------------------VLNGDIGPEESLASVAILQFYADNGISDTITIPDSAT-----NLDQLLAVIDGAAAIKT 394
|
....*.
gi 1766864855 727 KTLYYH 732
Cdd:cd00576 395 THVRVN 400
|
|
| PRK06539 |
PRK06539 |
ribonucleoside-diphosphate reductase subunit alpha; |
4-731 |
2.01e-76 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180610 [Multi-domain] Cd Length: 822 Bit Score: 263.32 E-value: 2.01e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 4 SLLVTKRDGSTERINLDKIHRVLDWAAEGLN-NVS-ISQVELRSHIQFYDGIKTADIHETIIKAAADLIsREAPDYQYLA 81
Cdd:PRK06539 2 SITVVKRDGSKEPYDANKVNAAIEDAARGLDdAITwVTQLASELEITLFDGITTQQLDEAVIQVALQNV-KDDPAFDTVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 82 ARLAIFHLRKKAYGQFEPPALF-----DHVSKMVKNGKYDTHLLEDYTEE-EFKQMDSFIEHDRDMTFSYAAVKQLEGKY 155
Cdd:PRK06539 81 ARLLLKKIYKRVLGDYDSPEELqdlhaNHFRRTIEKGVAEGLLDSRLGGLfDLERLAAALDPTRDELLKYIGVVTLNNRY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 156 LVQNRvTGEIYESAQFLYILVAACLFSNY--PRETRLdyikRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDS 233
Cdd:PRK06539 161 GIRAR-NGDALEVPQYFWMRIAMGLSLNEddPTSSAL----AFYEKMSKLEYLAAGSTLVNAGTPYPQLSNCFVMEMQDD 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 234 LDSINATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEV 313
Cdd:PRK06539 236 IEHIAKTTRDVMWLTKGTGGIGLSVSKLRAQGSPIRSNNTTSTGPIPFMHTIDSVLRAVSRGGKKFGALCFYMENWHMDF 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 314 ESLLVLKNNRGTDANRVRHMDYGVQINKLMYTRLLKGGDITLFSPSDVPGLYDAFFADqdeFERLYTQY----EQDDSIR 389
Cdd:PRK06539 316 PEFLDLRQNSGDPYRRTRTANTAVWISDEFMKRVQNDEDWYLFDPLETPDLNELYGKA---FSKRYAQYveqaEAGRIRM 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 390 KQRIKAVELFSLMMQERASTGRIYIQNVDHCNTHSpFDPVVAPVRQSNLCLEIALPtkpledvNDENgEIALCTLSAFNL 469
Cdd:PRK06539 393 FKRITAREQFRAILMSLQTTSHPWLTWKDTINNRA-LNNNTGTIHLSNLCTEICLP-------QDRD-NVSVCNLASINL 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 470 ------GVIDsLDELEELAVLAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKT 543
Cdd:PRK06539 464 srhladGELD-WAQLEESTRLAVRQLDNLIDITASSVKEADFSNQQNRAIGLGVMGFTDMVERLGYSYESEEAYDLIDRI 542
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 544 FEAIQYYLLKASNELAIEQGACPWFNETTYAKGILPIDTYK-----KDLDAIVSESLHYDWEQLRESIKThGLRNSTLSA 618
Cdd:PRK06539 543 MEHISYAAIDESADLAAERGAYPNFEGSRWSRGMVPVDSIAlleadRGVPVDVNRTTRLDWDALRAKVRG-GMRNATLMA 621
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 619 LMPSETSSQISNATNGIEPPRGHVSIKASKDG----ILRQVVPDYEKLQngyelLWEMPNND------------------ 676
Cdd:PRK06539 622 IAPTASIGLVAGTTPGLDPQFSQIFSRSTSSGkfleVNRNLVADLKELG-----LWETVREEilrsqgdiqeiaaipdei 696
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1766864855 677 -------------GYLQLVGIMQKFIDQSISANTnYDPTRfpsgkvPMQQLLKDLLNAYKFGVKTLYY 731
Cdd:PRK06539 697 kalyrtsfqlspyAFLEVAARAQKWVDQAISRNM-YLESR------DIGDMMDIYTAAWEMGVKTTYY 757
|
|
| NrdJ_Z |
TIGR02504 |
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a ... |
150-742 |
6.01e-52 |
|
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a group of adenosylcobalamin(B12)-dependent ribonucleotide reductases (Class II RNRs) related to the characterized species from Pyrococcus, Thermoplasma, Corynebacterium, and Deinococcus. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. This model identifies genes in a wide range of deeply branching bacteria. All are structurally related to the class I (non-heme iron dependent) RNRs. In most species this gene is known as NrdJ, while in mycobacteria it is called NrdZ. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274168 [Multi-domain] Cd Length: 575 Bit Score: 190.23 E-value: 6.01e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 150 QLEGKYLVQNRvTGEIYESAQFLYILVAACLFSN---YPRETRLDYIKRFYDAVSTFKISLPTPIMSGV-RTPTRQFSSC 225
Cdd:TIGR02504 1 VLAARYLLKDE-DGNIIESPEDLFRRVARALAAAedkYNSPVWKQWYERFYDLMVNLGFIPNSPTLMNAgGTRLGQLSAC 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 226 VLIECGDSLDSINATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLF 305
Cdd:TIGR02504 80 FVLPVEDSMEDIFEALKEAALIFKRGGGVGYNFSTLRPKGDLVSGTGGVASGPVSFMRVFDSAAGVVKQGGTRRGAQMGI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 306 YPMWHLEVESLLVLKNNRGtdanRVRHMDYGVqinklmytrllkggditlfspsdvpGLYDAFF--ADQDEferLYTQYE 383
Cdd:TIGR02504 160 LDVWHPDIEEFIEAKAKEG----KLQNFNISV-------------------------GVTDEFMeaVENDE---EYELRN 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 384 QDDSIRKQrIKAVELFSLMMQ---ERASTGRIYIQNVdhcNTHSPFDPVvAPVRQSNLCLEIALPtkPLEDvndengeia 460
Cdd:TIGR02504 208 PRTGEYKE-VDARELWDKIVEsawKSAEPGVLFIDTI---NKWHTCPYG-GRINATNPCGEQPLL--PYES--------- 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 461 lCTLSAFNL-----------GVIDsLDELEELAVLAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGK 529
Cdd:TIGR02504 272 -CNLGSINLakfvkndfgdeASFD-FERLREVVRLATRFLDNVIDINVFPLPEIAENTKKTRRIGLGIMGLADLLIKLGI 349
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 530 RYSDGSANNLTHKTFEAIQYYLLKASNELAIEQGACPWFNETTYAKGILPIDTYKKDLDAivseslhydweQLRESIKTH 609
Cdd:TIGR02504 350 PYDSEEARELAEEVMEFIADAAYRASAELAKERGAFPLYDASKYPMGRAMGARIPSALPA-----------EIREAIRKY 418
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 610 GLRNSTLSALMPSETSSQISNATNGIEPPRGHVSIKA-SKDGILRQVVPDYEK----LQNGYELLWEMPNNDGYLQ---- 680
Cdd:TIGR02504 419 GIRNAQLTTIAPTGTISLIAGTSSGIEPVFALVYFRNvTVGGELLEVNPLVELalreLGYYSDEIVKYVDEKGTVEgapg 498
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 681 ---------------------LVGIMQKFIDQSISANTNydptrFPSGkVPMQQLLKDLLNAYKFGVK--TLYyhntRDG 737
Cdd:TIGR02504 499 peelpkvfvtamdispedhvlMQAAIQPWVDSSISKTIN-----MPSD-ATVEDVKAVYLEAWKLGLKgiTVY----RDG 568
|
....*
gi 1766864855 738 AEDAQ 742
Cdd:TIGR02504 569 SRSSQ 573
|
|
| RNR_II_dimer |
cd02888 |
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the ... |
193-737 |
1.13e-47 |
|
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class II RNRs are found in bacteria that can live under both aerobic and anaerobic conditions. Many, but not all members of this class are found to be homodimers. Adenosylcobalamin interacts directly with an active site cysteine to form the reactive cysteine radical.
Pssm-ID: 153089 [Multi-domain] Cd Length: 464 Bit Score: 175.50 E-value: 1.13e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 193 IKRFYDAVSTFKISLPTPIMSGVRTPTR-QFSSC-VLIECGDSLDSINATSSAIVKYVSQRAGIGINAGRIRALGSPIRG 270
Cdd:cd02888 1 ADEFFYLLLSQGFIPNSPTLMNAGTGELgQLSACfVLPVEDDSIEGIFDALKEAALIFKRGGGVGYNFSRLRPKGDIVKS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 271 GEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEVESLLVLKNnRGTDANRVRHMDYGVqinklmytrllkg 350
Cdd:cd02888 81 TGGVASGPVSFMRVFDAATGVIKQGGTRRGANMGVLDVDHPDIEEFIDAKM-KEEKTVVLQNFNISV------------- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 351 gditlfspsdvpGLYDAFFA--DQDEFERLYTQYEQDDSIRKQRIKAVELFSLMMQ---ERASTGRIYIQNVDHCNTHsp 425
Cdd:cd02888 147 ------------AVTDAFMEavENDEPWELRNPREPDTGKVYRTVPARELWDKIVEaawDSADPGVLFIDTINRWNPL-- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 426 fdPVVAPVRQSNLCLEIALPtkPLEDvndengeialCTLSAFNL----------GVIDsLDELEELAVLAVRALDALLDY 495
Cdd:cd02888 213 --PGLGRINATNPCGEQPLL--PYES----------CNLGSINLskfvknpfggASFD-FERLREAVRLAVRFLDNVIDV 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 496 QDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAIEQGACPWFNETTYak 575
Cdd:cd02888 278 NRYPLPEIAEETKATRRIGLGVMGLADMLIKLGIPYDSEEARELAERIMSFIRDAAYRASAELAKERGPFPLFDASRY-- 355
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 576 gilpidtykkdLDAIVSESLHYDWEQLRESIKTHGLRNSTLSALMPSETSSQISNATNGIEP---PRGHVSIKASkdgil 652
Cdd:cd02888 356 -----------LMLKVIVNAKELPDDVLEEIEKYGIRNAHLTTIAPTGTISLIAGTSSGIEPifsPEDHVRMQAA----- 419
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 653 rqvvpdyeklqngyellwempnndgylqlvgiMQKFIDQSISANTNydptrFPSGkVPMQQLLKDLLNAYKFGVK--TLY 730
Cdd:cd02888 420 --------------------------------LQPWVDGAISKTIN-----LPND-ATVEDVEAVYLLAWKLGLKgiTVY 461
|
....*..
gi 1766864855 731 yhntRDG 737
Cdd:cd02888 462 ----RDG 464
|
|
| PRK09102 |
PRK09102 |
ribonucleoside-diphosphate reductase subunit alpha; |
151-731 |
1.42e-46 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236378 [Multi-domain] Cd Length: 601 Bit Score: 175.53 E-value: 1.42e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 151 LEGKYLVQNrvtgeiyESAQFLYILVAaclfsNYPRETRLDYIKRFYDAVSTFKISLPTPIMSGVRT----PTrqfsSCV 226
Cdd:PRK09102 29 LRDRYLLEG-------ESYQDLFARIA-----EAYADIDPEHAQRFYDYMSRGWFMPATPVLSNGGTdrglPI----SCF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 227 LIECGDSLDSINATSSAIVKYVSQRAGIGINAGRIRALGSPIRG-GEAfhTGCIPFYKHFQTAVKSCSQGGVRGGAATLF 305
Cdd:PRK09102 93 LNYVEDSLEGIVNTWNENVWLAKRGGGIGSYWGNVRSIGEPIRNnGKS--SGIIPFIKVMDSLTLAISQGSLRRGSFAVY 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 306 YPMWHLEVESLLVLKNNRGTDANRVRHMDYGVQINklmytrllkggditlfspsdvpglyDAFF---ADQDEFERLytqy 382
Cdd:PRK09102 171 LDIEHPEIEEFLDIRKPTGDPNRKALNLHHGVCVT-------------------------DEFMeavEDGDEWDLI---- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 383 EQDDSIRKQRIKAVELFSLMMQERASTGRIYIQNVDHCNTHSP--FDPVVAPVRQSNLCLEIALPTKplEDVNDENgEIA 460
Cdd:PRK09102 222 SPKDKSVIRTVKARDLWAKILETRIETGEPYLLFIDNVNRALPevYKDLGLKVKASNLCSEITLPTG--IDHLGED-RTA 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 461 LCTLSAFNLGVIDSLDELEELAVLAVRALDALLdyQDY------PIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDG 534
Cdd:PRK09102 299 VCCLSSLNLEYYDEWKDTDAFIEDLMRFLDNVL--QDFidkapdEMERAKYSAMRERSVGLGVMGFHSYLQSKMIPFESV 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 535 SANNLTHKTFEAIQYYLLKASNELAIEQGACPWfnettyAKGilpidtykkdldaivseslhYDWEQlresikthglRNS 614
Cdd:PRK09102 377 MAKQWNKKIFKHIREQADKASKELAKEKGECPD------AAG--------------------YGVMR----------RFS 420
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 615 TLSALMPSETSSQIS-NATNGIEPPRGHVSIKASKDGILRQVVPDYEKL--QNGY--ELLWE-MPNNDGYLQ-------- 680
Cdd:PRK09102 421 TKMAIAPTASISIILgNTSPGIEPIAANYYTHKTLKGSFTVKNKYLEKLleEKGKdtDEVWSsILTNEGSVQhldflsee 500
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1766864855 681 ------------------LVGIMQKFIDQSISANTNydptrFPSGkVPMQQLLKDLLNAYKFGVKTLYY 731
Cdd:PRK09102 501 ekdvfktafeidqrwiieLAADRQKYIDQAQSLNLF-----LPAN-VPKRDLNKLHFEAWKKGVKSLYY 563
|
|
| PRK08665 |
PRK08665 |
vitamin B12-dependent ribonucleotide reductase; |
140-637 |
1.84e-22 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236330 [Multi-domain] Cd Length: 752 Bit Score: 103.09 E-value: 1.84e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 140 DMTFSYAAVKQLEGKYLVQNRvTGEIYESAQFLYILVAACLFS---NYPRETRLDYI-KRFYDAVSTFKIsLP-TPIMSG 214
Cdd:PRK08665 9 DMKLTDNALTVLEKRYLKKDE-DGKPIETPEDMFRRVARTIAAaelIYDSKADVEALaDRFYDLMTSLEF-LPnSPTLMN 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 215 VRTPTRQFSSCVLIECGDSLDSINATssaiVKYVS----QRAGIGINAGRIRALGSPIR--GGEAfhTGCIPFYKHFQTA 288
Cdd:PRK08665 87 AGRELGQLSACFVLPVGDSIEEIFDA----VKHAAlihkSGGGTGFSFSRLRPKNDRVGstGGVA--SGPVSFMRVFDAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 289 VKSCSQGGVRGGAatlfypmwhlevesllvlknNRGTdaNRVRHMDygvqINKLMYTRLlKGGDITLFSPSdVpGLYDAF 368
Cdd:PRK08665 161 TEAIKQGGTRRGA--------------------NMGI--LRVDHPD----IMEFITCKE-DNGELTNFNIS-V-AITEAF 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 369 F----ADQDeferlYTQYEQDDSIRKQRIKAVELFSLMMQERASTGRIYIQNVDHCNTHSPfDPVVAPVRQSNLCLEIAL 444
Cdd:PRK08665 212 MeaveADEE-----YDLINPRTGEVVGRLNAREVFDLIVEMAWENGEPGIVFIDRINRDNP-TPHLGEIESTNPCGEQPL 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 445 PtkPLEDvndengeialCTLSAFNL------GVIDsLDELEELAVLAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVI 518
Cdd:PRK08665 286 L--PYES----------CNLGSINLskmvknGDVD-WEKLREVVHLAVRFLDNVIDANKYPLPQIEEMTKGNRKIGLGVM 352
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 519 NFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAIEQGACPWFNETTYAK-GILPIdtykkdldaivseslhy 597
Cdd:PRK08665 353 GWADMLIQLGIPYDSEEAVELAEKVMKFIQDEAHAASRELAEERGPFPNYEGSIYDKdGLGPM----------------- 415
|
490 500 510 520
....*....|....*....|....*....|....*....|
gi 1766864855 598 dweqlresikthglRNSTLSALMPSETSSQISNATNGIEP 637
Cdd:PRK08665 416 --------------RNATVTTIAPTGTISIIAGCSSGIEP 441
|
|
| PRK06406 |
PRK06406 |
vitamin B12-dependent ribonucleotide reductase; |
192-637 |
6.55e-22 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 235796 [Multi-domain] Cd Length: 771 Bit Score: 101.08 E-value: 6.55e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 192 YIKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSI-NATSSAIVKYVSQrAGIGINAGRIRALGSPIRG 270
Cdd:PRK06406 219 YINKFEEVMSNLKFVPNSPTLMNAGTKLGQLSACFVLPVPDSIEGIfNALKYTAMIHKSG-GGTGFSFSRLRPKDDIVAS 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 271 GEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEVESLLVLKNNRgtdaNRVrhmdygvqinklmytrlLKG 350
Cdd:PRK06406 298 TKGVASGPLSFMRIFDVTTDVIKQGGKRRGANMGILSYHHPDIMEFITSKDSE----NKV-----------------LSN 356
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 351 GDITLfspsdvpGLYDAFFA--DQDEFERLYTqyEQDDSIRKqRIKAVELFSLMMQERASTGRIYIQNVDHCNTHSPFDP 428
Cdd:PRK06406 357 FNISV-------AVTDEFFDklDNDDYYPLRN--PRNGKEVK-RIKARQVWDLIITQAWKTGDPGVIFLDEINRKNPVKN 426
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 429 VvAPVRQSNLCLEiaLPTKPLEDvndengeialCTLSAFNL------GVIDsLDELEELAVLAVRALDALLDYQDYPIPA 502
Cdd:PRK06406 427 L-GEIESTNPCGE--QPLLPYES----------CNLGSINLskfvenGKID-WDRLRETVHIATRFLDNVIDANKFPVPQ 492
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 503 AKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAIEQGACP-WFNEttyakgilpid 581
Cdd:PRK06406 493 IKEMTRMTRKIGLGVMGFADMLIKLGIPYNSEEALEIAEKVMKFINEESHRASQKLAEERGVFPaWYGS----------- 561
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 1766864855 582 tykkdldaivseslhyDWEqlRESIKthgLRNSTLSALMPSETSSQISNATNGIEP 637
Cdd:PRK06406 562 ----------------EWE--KKGIK---MRNSTTTTIAPTGTISIIAGCSSSIEP 596
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
458-680 |
2.52e-18 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 90.21 E-value: 2.52e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 458 EIALCTLSAFNLGVIDSLDE-------LEELAVL---AVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKH 527
Cdd:PRK08332 1304 EYESCNLASINLAKFVKYDEngkpyfdWDEYAYViqkVAKYLDNAIDVNKFPLPEIDYNTKLTRRIGVGMMGLADALFKL 1383
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 528 GKRYSDGSANNLTHKTFEAIQYYLLKASNELAIEQGACPWFNETTYAKGILPIDTYKKdldaivSESLHYDWEQLRESIK 607
Cdd:PRK08332 1384 GIPYNSEEGFKFMRKVTEYLTFYAYKYSVEAAKKRGTFPLYEKTEYPKGELPVEGFYH------PEIWNLPWDKLVEEIK 1457
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1766864855 608 THGLRNSTLSALMPSETSSQISNATNGIEPPRGHVSIKASKDGILRQVVPDYE---KLQNGY--ELLWEMPNNDGYLQ 680
Cdd:PRK08332 1458 KYGVRNAMVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEaelKKRGLYseELLKKISDNYGSVQ 1535
|
|
| PRK08115 |
PRK08115 |
vitamin B12-dependent ribonucleotide reductase; |
187-742 |
6.55e-17 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236152 [Multi-domain] Cd Length: 858 Bit Score: 85.28 E-value: 6.55e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 187 ETRLDYIKRFYDAVSTFKISLPTPIM--SGVRTPTRQFSSCVLIECGDSLDSINATSSAIVKYVSQRAGIGINAGRIRAL 264
Cdd:PRK08115 150 EKRKESFEKFYQELVNMNFVPAGRVLygAGSKTDVTYFNCYVMPFVKDSREGISEHRKQVMEIMSRGGGVGTNGSTLRPR 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 265 GSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEVESLLVLK--NNR-------GTDANRVRH--- 332
Cdd:PRK08115 230 NTLARGVNGKSSGSVSWLDDIAKLTHLVEQGGSRRGAQMIMLADWHPDILEFIISKmqNPRilrylleNTEDEQIKRlvk 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 333 -------------------------MDYGVQINKLMY---TRLLKGGDITLFSPSDVPG------LYDAFF--ADQDEFE 376
Cdd:PRK08115 310 eklkftplseveeamyqaivnykniEGQGGFDTKVIKeaeNKLRTGGTYTVNNPEFLTGanisvcLTKEFMeaVENDEEY 389
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 377 RL-------YTQYEQDD-------------------SIRKQR-IKAVELFSLM---MQERASTGRIYIQNV-DHCNTHSP 425
Cdd:PRK08115 390 ELrfpdvenYTEEEMEIyneewhevgdvrewekmgyPVRTYRkIKAKELWNLInicATYSAEPGIFFIDNAnEMTNAKAY 469
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 426 FDPVVApvrqSNLCLEialptKPLedvndenGEIALCTLSAFNL--------GVIDsLDELEELAVLAVRALDALLDYQD 497
Cdd:PRK08115 470 GQKVVA----TNPCGE-----QPL-------APYSVCNLAAINLanmadketKTVD-YEKLKRTVEVGVRMQDNVIDATP 532
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 498 YPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAIEQGACPWF-----NETT 572
Cdd:PRK08115 533 YFLEENKKQALGERRVGLGVMGLHDLLIYCETVYGSEEGNQLVDQIFETIATTAYRTSIELAKEKGSFPFLvgqteEETA 612
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 573 YAKGILPIDTYKKDLDAIVseslhydweqlRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPprgHVSIKASKDGIL 652
Cdd:PRK08115 613 KLREAFINTGYMKKMPEDI-----------REDILKYGIRNSHLLTVAPTGSTGTMVGVSTGLEP---YFSFSYYRSGRL 678
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 653 -------RQVVPDYEKLQNgyellWEMPNN-------------DGYLQLVGIMQKFIDQSISANTNYdptrfPSGkVPMQ 712
Cdd:PRK08115 679 gkfievkADIVQEYLDKHP-----EADENHlpewfisamelkpEAHADVQCIIQRWVDSSLSKTVNA-----PKG-YTVE 747
|
650 660 670
....*....|....*....|....*....|..
gi 1766864855 713 QLLKDLLNAYKFGVK--TLYYhntrDGAEDAQ 742
Cdd:PRK08115 748 QVQKVYERLYRGGAKggTVYV----DGSRDAQ 775
|
|
| Ribonuc_red_lgN |
pfam00317 |
Ribonucleotide reductase, all-alpha domain; |
143-218 |
4.34e-16 |
|
Ribonucleotide reductase, all-alpha domain;
Pssm-ID: 459758 [Multi-domain] Cd Length: 75 Bit Score: 73.43 E-value: 4.34e-16
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1766864855 143 FSYAAVKQLEGKYLVQNRvTGEIYESAQFLYILVAACLFSNYPRETRLDYIKRFYDAVSTFKISLPTPIMSGVRTP 218
Cdd:pfam00317 1 LTYLGAKVLEDRYLLKDE-DGELLETPQDMFMRVALALAGAELEEDRLELAEEFYDLLSSLKFLPATPTLMNAGTP 75
|
|
| ATP-cone |
pfam03477 |
ATP cone domain; |
5-92 |
3.40e-14 |
|
ATP cone domain;
Pssm-ID: 397513 [Multi-domain] Cd Length: 86 Bit Score: 68.45 E-value: 3.40e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 5 LLVTKRDGSTERINLDKIHRVLDWAAEGLNNVS---ISQVELRSHIQFYDGIKTADIHETIIKAAadlisREAPDYQYLA 81
Cdd:pfam03477 1 MKVIKRDGRREPFDKEKIRRAIEKACEKSPDQAdelASEVEEELEKSLEDGISTEEIQDLVEKTL-----AEHPDYAVAR 75
|
90
....*....|.
gi 1766864855 82 ARLAIFHLRKK 92
Cdd:pfam03477 76 AYILYRNLRKE 86
|
|
| PRK06948 |
PRK06948 |
ribonucleotide reductase-like protein; Provisional |
486-640 |
8.15e-12 |
|
ribonucleotide reductase-like protein; Provisional
Pssm-ID: 180772 [Multi-domain] Cd Length: 595 Bit Score: 68.67 E-value: 8.15e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 486 VRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAIEQGAC 565
Cdd:PRK06948 338 VRMLDNALDLTRWPLAAHAREARQKRRIGVGVTGLADALTMMRLRYDSPAAREMARYIASDLRHHAYAASAALAAERGAY 417
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1766864855 566 PWFNETTYAKG-----ILPIdtykkdldaivseslhydweQLRESIKTHGLRNSTLSALMPSETSSQI--SNATNGIEPP 638
Cdd:PRK06948 418 PLCDPAAHLDAlragpPLPH--------------------AVCHAIARHGLRNSHLLSFAPVGSVSLAfgDNCSPGIEPA 477
|
..
gi 1766864855 639 RG 640
Cdd:PRK06948 478 RA 479
|
|
| |
