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Conserved domains on  [gi|1768216513|gb|KAB7923592|]
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bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD [Klebsiella pneumoniae]

Protein Classification

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase( domain architecture ID 11484949)

bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/ 5,10-methenyltetrahydrofolate cyclohydrolase reversibly catalyzes oxidation of 5,10-methylene-THF to 5,10-methenyl-THF and hydrolysis of 5,10-methenyl-THF to 10-formyl-THF

CATH:  3.40.50.720|3.40.50.10860
EC:  1.5.1.5|3.5.4.9
Gene Ontology:  GO:0004488|GO:0003824|GO:0016787|GO:0009086|GO:0006164|GO:0006730
PubMed:  1748668|10386884
SCOP:  4000102

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10792 PRK10792
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 1-285 0e+00

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


:

Pssm-ID: 236760 [Multi-domain]  Cd Length: 285  Bit Score: 616.93  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   1 MAAKIIDGKTIAQQVRSEVAEKVKARVAAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELL 80
Cdd:PRK10792    1 MTAKIIDGKTIAQQVRSEVAQKVQARVAAGLRAPGLAVVLVGSDPASQVYVASKRKACEEVGFVSRSYDLPETTSEAELL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  81 ELIDTLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGL 160
Cdd:PRK10792   81 ALIDELNADPTIDGILVQLPLPAHIDNVKVLERIHPDKDVDGFHPYNVGRLAQRIPLLRPCTPRGIMTLLERYGIDTYGL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 161 NAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKV 240
Cdd:PRK10792  161 NAVVVGASNIVGRPMSLELLLAGCTVTVCHRFTKNLRHHVRNADLLVVAVGKPGFIPGEWIKPGAIVIDVGINRLEDGKL 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1768216513 241 VGDVVYEDAAERASYITPVPGGVGPMTVATLIQNTLQACEEYHDV 285
Cdd:PRK10792  241 VGDVEFETAAERASWITPVPGGVGPMTVATLLENTLQACEEYHDP 285
 
Name Accession Description Interval E-value
PRK10792 PRK10792
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 1-285 0e+00

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 236760 [Multi-domain]  Cd Length: 285  Bit Score: 616.93  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   1 MAAKIIDGKTIAQQVRSEVAEKVKARVAAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELL 80
Cdd:PRK10792    1 MTAKIIDGKTIAQQVRSEVAQKVQARVAAGLRAPGLAVVLVGSDPASQVYVASKRKACEEVGFVSRSYDLPETTSEAELL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  81 ELIDTLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGL 160
Cdd:PRK10792   81 ALIDELNADPTIDGILVQLPLPAHIDNVKVLERIHPDKDVDGFHPYNVGRLAQRIPLLRPCTPRGIMTLLERYGIDTYGL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 161 NAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKV 240
Cdd:PRK10792  161 NAVVVGASNIVGRPMSLELLLAGCTVTVCHRFTKNLRHHVRNADLLVVAVGKPGFIPGEWIKPGAIVIDVGINRLEDGKL 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1768216513 241 VGDVVYEDAAERASYITPVPGGVGPMTVATLIQNTLQACEEYHDV 285
Cdd:PRK10792  241 VGDVEFETAAERASWITPVPGGVGPMTVATLLENTLQACEEYHDP 285
FolD COG0190
5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase ...
 1-286 0e+00

5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism];


Pssm-ID: 439960 [Multi-domain]  Cd Length: 285  Bit Score: 517.26  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   1 MAAKIIDGKTIAQQVRSEVAEKVKARVAAGkRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELL 80
Cdd:COG0190     1 MMAQILDGKAVAAEIREELKERVAALKAKG-ITPGLAVVLVGDDPASQVYVRNKHKACEEVGIESELIRLPADTTQEELL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  81 ELIDTLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGL 160
Cdd:COG0190    80 ALIDELNADPSVHGILVQLPLPKHIDEEAVLEAIDPEKDVDGFHPVNLGRLVLGEPGFVPCTPAGIMELLERYGIDLAGK 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 161 NAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKV 240
Cdd:COG0190   160 HAVVVGRSNIVGKPLALLLLRRNATVTVCHSRTKDLAEHTRQADILVAAVGKPGLITADMVKPGAVVIDVGINRVEDGKL 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1768216513 241 VGDVVYEDAAERASYITPVPGGVGPMTVATLIQNTLQACEEYHDVE 286
Cdd:COG0190   240 VGDVDFESVAEKASAITPVPGGVGPMTIAMLLENTLKAAERQAGLR 285
THF_DHG_CYH_C pfam02882
Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;
124-283 1.16e-95

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;


Pssm-ID: 427036  Cd Length: 160  Bit Score: 278.58  E-value: 1.16e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENA 203
Cdd:pfam02882   1 HPYNLGRLVLGKPCFVPCTPRGIMELLKRYGIDLAGKNVVVVGRSNIVGKPLALLLLNANATVTVCHSKTKDLAEITREA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 204 DLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKVVGDVVYEDAAERASYITPVPGGVGPMTVATLIQNTLQACEEYH 283
Cdd:pfam02882  81 DIVVVAVGKPELIKADWIKPGAVVIDVGINRVGNGKLVGDVDFENVKEKASAITPVPGGVGPMTVAMLLQNTVEAAKRQL 160
NAD_bind_m-THF_DH_Cyclohyd cd01080
NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NADP binding ...
 116-280 2.08e-90

NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NADP binding domain of the Methylene-Tetrahydrofolate Dehydrogenase/cyclohydrolase (m-THF DH/cyclohydrolase) bifunctional enzyme. Tetrahydrofolate is a versatile carrier of activated one-carbon units. The major one-carbon folate donors are N-5 methyltetrahydrofolate, N5,N10-m-THF, and N10-formayltetrahydrofolate. The oxidation of metabolic intermediate m-THF to m-THF requires the enzyme m-THF DH. In addition, most DHs also have an associated cyclohydrolase activity which catalyzes its hydrolysis to N10-formyltetrahydrofolate. m-THF DH is typically found as part of a multifunctional protein in eukaryotes. NADP-dependent m-THF DH in mammals, birds and yeast are components of a trifunctional enzyme with DH, cyclohydrolase, and synthetase activities. Certain eukaryotic cells also contain homodimeric bifunctional DH/cyclodrolase form. In bacteria, monofucntional DH, as well as bifunctional m-THF m-THF DHm-THF DHDH/cyclodrolase are found. In addition, yeast (S. cerevisiae) also express an monofunctional DH. This family contains the bifunctional DH/cyclohydrolase. M-THF DH, like other amino acid DH-like NAD(P)-binding domains, is a member of the Rossmann fold superfamily which includes glutamate, leucine, and phenylalanine DHs, m-THF DH, methylene-tetrahydromethanopterin DH, m-THF DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains.


Pssm-ID: 133448  Cd Length: 168  Bit Score: 265.57  E-value: 2.08e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 116 PDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKN 195
Cdd:cd01080     1 PEKDVDGLHPVNLGRLALGRPGFIPCTPAGILELLKRYGIDLAGKKVVVVGRSNIVGKPLAALLLNRNATVTVCHSKTKN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 196 LRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLE---SGKVVGDVVYEDAAERASYITPVPGGVGPMTVATLI 272
Cdd:cd01080    81 LKEHTKQADIVIVAVGKPGLVKGDMVKPGAVVIDVGINRVPdksGGKLVGDVDFESAKEKASAITPVPGGVGPMTVAMLM 160


                  ....*...
gi 1768216513 273 QNTLQACE 280
Cdd:cd01080   161 KNTVEAAK 168
 
Name Accession Description Interval E-value
PRK10792 PRK10792
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 1-285 0e+00

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 236760 [Multi-domain]  Cd Length: 285  Bit Score: 616.93  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   1 MAAKIIDGKTIAQQVRSEVAEKVKARVAAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELL 80
Cdd:PRK10792    1 MTAKIIDGKTIAQQVRSEVAQKVQARVAAGLRAPGLAVVLVGSDPASQVYVASKRKACEEVGFVSRSYDLPETTSEAELL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  81 ELIDTLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGL 160
Cdd:PRK10792   81 ALIDELNADPTIDGILVQLPLPAHIDNVKVLERIHPDKDVDGFHPYNVGRLAQRIPLLRPCTPRGIMTLLERYGIDTYGL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 161 NAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKV 240
Cdd:PRK10792  161 NAVVVGASNIVGRPMSLELLLAGCTVTVCHRFTKNLRHHVRNADLLVVAVGKPGFIPGEWIKPGAIVIDVGINRLEDGKL 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1768216513 241 VGDVVYEDAAERASYITPVPGGVGPMTVATLIQNTLQACEEYHDV 285
Cdd:PRK10792  241 VGDVEFETAAERASWITPVPGGVGPMTVATLLENTLQACEEYHDP 285
FolD COG0190
5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase ...
 1-286 0e+00

5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism];


Pssm-ID: 439960 [Multi-domain]  Cd Length: 285  Bit Score: 517.26  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   1 MAAKIIDGKTIAQQVRSEVAEKVKARVAAGkRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELL 80
Cdd:COG0190     1 MMAQILDGKAVAAEIREELKERVAALKAKG-ITPGLAVVLVGDDPASQVYVRNKHKACEEVGIESELIRLPADTTQEELL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  81 ELIDTLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGL 160
Cdd:COG0190    80 ALIDELNADPSVHGILVQLPLPKHIDEEAVLEAIDPEKDVDGFHPVNLGRLVLGEPGFVPCTPAGIMELLERYGIDLAGK 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 161 NAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKV 240
Cdd:COG0190   160 HAVVVGRSNIVGKPLALLLLRRNATVTVCHSRTKDLAEHTRQADILVAAVGKPGLITADMVKPGAVVIDVGINRVEDGKL 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1768216513 241 VGDVVYEDAAERASYITPVPGGVGPMTVATLIQNTLQACEEYHDVE 286
Cdd:COG0190   240 VGDVDFESVAEKASAITPVPGGVGPMTIAMLLENTLKAAERQAGLR 285
PRK14190 PRK14190
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 1-285 2.37e-134

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 184560 [Multi-domain]  Cd Length: 284  Bit Score: 381.28  E-value: 2.37e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   1 MAAKIIDGKTIAQQVRSEVAEKVKARVAAGKrAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELL 80
Cdd:PRK14190    1 MMAVIIDGKEVAKEKREQLKEEVVKLKEQGI-VPGLAVILVGDDPASHSYVRGKKKAAEKVGIYSELYEFPADITEEELL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  81 ELIDTLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGL 160
Cdd:PRK14190   80 ALIDRLNADPRINGILVQLPLPKHIDEKAVIERISPEKDVDGFHPINVGRMMLGQDTFLPCTPHGILELLKEYNIDISGK 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 161 NAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKV 240
Cdd:PRK14190  160 HVVVVGRSNIVGKPVGQLLLNENATVTYCHSKTKNLAELTKQADILIVAVGKPKLITADMVKEGAVVIDVGVNRLENGKL 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1768216513 241 VGDVVYEDAAERASYITPVPGGVGPMTVATLIQNTLQACEEYHDV 285
Cdd:PRK14190  240 CGDVDFDNVKEKASYITPVPGGVGPMTITMLMHNTVELAKRAGGR 284
PRK14189 PRK14189
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;
1-280 1.70e-130

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;


Pssm-ID: 184559 [Multi-domain]  Cd Length: 285  Bit Score: 371.71  E-value: 1.70e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   1 MAAKIIDGKTIAQQVRSEVAEKVKARVAAGKRaPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELL 80
Cdd:PRK14189    1 MTAQLIDGNALSKQLRAEAAQRAAALTARGHQ-PGLAVILVGDNPASQVYVRNKVKACEDNGFHSLKDRYPADLSEAELL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  81 ELIDTLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGL 160
Cdd:PRK14189   80 ARIDELNRDPKIHGILVQLPLPKHIDSHKVIEAIAPEKDVDGFHVANAGALMTGQPLFRPCTPYGVMKMLESIGIPLRGA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 161 NAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKV 240
Cdd:PRK14189  160 HAVVIGRSNIVGKPMAMLLLQAGATVTICHSKTRDLAAHTRQADIVVAAVGKRNVLTADMVKPGATVIDVGMNRDDAGKL 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1768216513 241 VGDVVYEDAAERASYITPVPGGVGPMTVATLIQNTLQACE 280
Cdd:PRK14189  240 CGDVDFAGVKEVAGYITPVPGGVGPMTITMLLVNTIEAAE 279
PRK14191 PRK14191
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 4-280 4.22e-128

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172679 [Multi-domain]  Cd Length: 285  Bit Score: 365.63  E-value: 4.22e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   4 KIIDGKTIAQQVRSEVAEKVKARVAAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLELI 83
Cdd:PRK14191    2 VLLDGKALSYKIEKDLKNKIQILTAQTGKRPKLAVILVGKDPASQTYVNMKIKACERVGMDSDLHTLQENTTEAELLSLI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  84 DTLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNAV 163
Cdd:PRK14191   82 KDLNTDQNIDGILVQLPLPRHIDTKMVLEAIDPNKDVDGFHPLNIGKLCSQLDGFVPATPMGVMRLLKHYHIEIKGKDVV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 164 VIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKVVGD 243
Cdd:PRK14191  162 IIGASNIVGKPLAMLMLNAGASVSVCHILTKDLSFYTQNADIVCVGVGKPDLIKASMVKKGAVVVDIGINRLNDGRLVGD 241

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1768216513 244 VVYEDAAERASYITPVPGGVGPMTVATLIQNTLQACE 280
Cdd:PRK14191  242 VDFENVAPKASFITPVPGGVGPMTIVSLLENTLIAAE 278
PRK14188 PRK14188
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 2-279 1.30e-127

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 184558 [Multi-domain]  Cd Length: 296  Bit Score: 364.66  E-value: 1.30e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   2 AAKIIDGKTIAQQVRSEVAEKVKARVAAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLE 81
Cdd:PRK14188    1 MATIIDGKAFAADVRATVAAEVARLKAAHGVTPGLAVVLVGEDPASQVYVRSKGKQTKEAGMASFEHKLPADTSQAELLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  82 LIDTLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLN 161
Cdd:PRK14188   81 LIARLNADPAIHGILVQLPLPKHLDSEAVIQAIDPEKDVDGLHVVNAGRLATGETALVPCTPLGCMMLLRRVHGDLSGLN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 162 AVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLES---- 237
Cdd:PRK14188  161 AVVIGRSNLVGKPMAQLLLAANATVTIAHSRTRDLPAVCRRADILVAAVGRPEMVKGDWIKPGATVIDVGINRIPApekg 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1768216513 238 ---GKVVGDVVYEDAAERASYITPVPGGVGPMTVATLIQNTLQAC 279
Cdd:PRK14188  241 egkTRLVGDVAFAEAAEVAGAITPVPGGVGPMTIACLLANTLTAA 285
PRK14186 PRK14186
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 3-278 1.99e-121

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 237636 [Multi-domain]  Cd Length: 297  Bit Score: 349.36  E-value: 1.99e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   3 AKIIDGKTIAQQVRSEVAEKVKARVAAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLEL 82
Cdd:PRK14186    2 ALILDGKALAAEIEQRLQAQIESNLPKAGRPPGLAVLRVGDDPASAVYVRNKEKACARVGIASFGKHLPADTSQAEVEAL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  83 IDTLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNA 162
Cdd:PRK14186   82 IAQLNQDERVDGILLQLPLPKHLDEVPLLHAIDPDKDADGLHPLNLGRLVKGEPGLRSCTPAGVMRLLRSQQIDIAGKKA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 163 VVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLES----G 238
Cdd:PRK14186  162 VVVGRSILVGKPLALMLLAANATVTIAHSRTQDLASITREADILVAAAGRPNLIGAEMVKPGAVVVDVGIHRLPSsdgkT 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1768216513 239 KVVGDVVYEDAAERASYITPVPGGVGPMTVATLIQNTLQA 278
Cdd:PRK14186  242 RLCGDVDFEEVEPVAAAITPVPGGVGPMTVTMLLVNTVLS 281
PRK14184 PRK14184
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 5-278 2.08e-119

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 237635 [Multi-domain]  Cd Length: 286  Bit Score: 343.68  E-value: 2.08e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   5 IIDGKTIAQQVRSEVAEKVKARVAAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLELID 84
Cdd:PRK14184    3 LLDGKATAATIREELKTEVAALTARHGRAPGLAVILVGEDPASQVYVRNKERACEDAGIVSEAFRLPADTTQEELEDLIA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  85 TLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNAVV 164
Cdd:PRK14184   83 ELNARPDIDGILLQLPLPKGLDSQRCLELIDPAKDVDGFHPENMGRLALGLPGFRPCTPAGVMTLLERYGLSPAGKKAVV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 165 IGASNIVGRPMSMELLLAG----CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGkV 240
Cdd:PRK14184  163 VGRSNIVGKPLALMLGAPGkfanATVTVCHSRTPDLAEECREADFLFVAIGRPRFVTADMVKPGAVVVDVGINRTDDG-L 241

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1768216513 241 VGDVVYEDAAERASYITPVPGGVGPMTVATLIQNTLQA 278
Cdd:PRK14184  242 VGDCDFEGLSDVASAITPVPGGVGPMTIAQLLVNTVQS 279
PRK14179 PRK14179
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;
3-279 1.87e-113

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;


Pssm-ID: 237634 [Multi-domain]  Cd Length: 284  Bit Score: 328.63  E-value: 1.87e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   3 AKIIDGKTIAQQVRSEVAEKVKARVAAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLEL 82
Cdd:PRK14179    2 TEIIDGKALAQKMQAELAEKVAKLKEEKGIVPGLVVILVGDNPASQVYVRNKERSALAAGFKSEVVRLPETISQEELLDL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  83 IDTLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNA 162
Cdd:PRK14179   82 IERYNQDPTWHGILVQLPLPKHINEEKILLAIDPKKDVDGFHPMNTGHLWSGRPVMIPCTPAGIMEMFREYNVELEGKHA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 163 VVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKVVG 242
Cdd:PRK14179  162 VVIGRSNIVGKPMAQLLLDKNATVTLTHSRTRNLAEVARKADILVVAIGRGHFVTKEFVKEGAVVIDVGMNRDENGKLIG 241

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1768216513 243 DVVYEDAAERASYITPVPGGVGPMTVATLIQNTLQAC 279
Cdd:PRK14179  242 DVDFDEVAEVASYITPVPGGVGPMTITMLMEQTYQAA 278
PRK14183 PRK14183
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 4-278 1.12e-112

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 184555 [Multi-domain]  Cd Length: 281  Bit Score: 326.40  E-value: 1.12e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   4 KIIDGKTIAQQVRSEVAEKVKARVAAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLELI 83
Cdd:PRK14183    2 QILDGKALSDKIKENVKKEVDELKLVKNIVPGLAVILVGDDPASHTYVKMKAKACDRVGIYSITHEMPSTISQKEILETI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  84 DTLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNAV 163
Cdd:PRK14183   82 AMMNNNPNIDGILVQLPLPKHIDTTKILEAIDPKKDVDGFHPYNVGRLVTGLDGFVPCTPLGVMELLEEYEIDVKGKDVC 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 164 VIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKVVGD 243
Cdd:PRK14183  162 VVGASNIVGKPMAALLLNANATVDICHIFTKDLKAHTKKADIVIVGVGKPNLITEDMVKEGAIVIDIGINRTEDGRLVGD 241

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1768216513 244 VVYEDAAERASYITPVPGGVGPMTVATLIQNTLQA 278
Cdd:PRK14183  242 VDFENVAKKCSYITPVPGGVGPMTIAMLLSNTLKA 276
PRK14176 PRK14176
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 4-281 1.93e-107

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 184553 [Multi-domain]  Cd Length: 287  Bit Score: 313.28  E-value: 1.93e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   4 KIIDGKTIAQQVRSEVAEKVKARVAAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLELI 83
Cdd:PRK14176    9 RIIDGKALAKKIEAEVRSGVERLKSNRGITPGLATILVGDDPASKMYVRLKHKACERVGIRAEDQFLPADTTQEELLELI 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  84 DTLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNAV 163
Cdd:PRK14176   89 DSLNKRKDVHGILLQLPLPKHLDPQEAMEAIDPAKDADGFHPYNMGKLMIGDEGLVPCTPHGVIRALEEYGVDIEGKNAV 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 164 VIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRlESGKVVGD 243
Cdd:PRK14176  169 IVGHSNVVGKPMAAMLLNRNATVSVCHVFTDDLKKYTLDADILVVATGVKHLIKADMVKEGAVIFDVGITK-EEDKVYGD 247

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1768216513 244 VVYEDAAERASYITPVPGGVGPMTVATLIQNTLQACEE 281
Cdd:PRK14176  248 VDFENVIKKASLITPVPGGVGPLTIAMLMKHVLMCAEK 285
PRK14166 PRK14166
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 5-280 4.76e-107

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 172654 [Multi-domain]  Cd Length: 282  Bit Score: 312.34  E-value: 4.76e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   5 IIDGKTIAQQVRSEVAEKVKARVAAGKRaPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLELID 84
Cdd:PRK14166    3 LLDGKALSAKIKEELKEKNQFLKSKGIE-SCLAVILVGDNPASQTYVKSKAKACEECGIKSLVYHLNENTTQNELLALIN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  85 TLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRL-CQRAPRLRPCTPRGIVTLLERYNIDTYGLNAV 163
Cdd:PRK14166   82 TLNHDDSVHGILVQLPLPDHICKDLILESIISSKDVDGFHPINVGYLnLGLESGFLPCTPLGVMKLLKAYEIDLEGKDAV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 164 VIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKVVGD 243
Cdd:PRK14166  162 IIGASNIVGRPMATMLLNAGATVSVCHIKTKDLSLYTRQADLIIVAAGCVNLLRSDMVKEGVIVVDVGINRLESGKIVGD 241

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1768216513 244 VVYEDAAERASYITPVPGGVGPMTVATLIQNTLQACE 280
Cdd:PRK14166  242 VDFEEVSKKSSYITPVPGGVGPMTIAMLLENTVKSAK 278
PRK14193 PRK14193
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 1-280 6.23e-103

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 237637 [Multi-domain]  Cd Length: 284  Bit Score: 301.93  E-value: 6.23e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   1 MAAKIIDGKTIAQQVRSEVAEKVKARVAAGkRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELL 80
Cdd:PRK14193    1 MTAIILDGKATADEIKADLAERVAALKEKG-ITPGLGTVLVGDDPGSQAYVRGKHRDCAEVGITSIRRDLPADATQEELN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  81 ELIDTLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGL 160
Cdd:PRK14193   80 AVIDELNADPACTGYIVQLPLPKHLDENAVLERIDPAKDADGLHPTNLGRLVLNEPAPLPCTPRGIVHLLRRYDVELAGA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 161 NAVVIGASNIVGRPMSMELLLAGCTTTVT--HRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESG 238
Cdd:PRK14193  160 HVVVIGRGVTVGRPIGLLLTRRSENATVTlcHTGTRDLAAHTRRADIIVAAAGVAHLVTADMVKPGAAVLDVGVSRAGDG 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1768216513 239 KVVGDvVYEDAAERASYITPVPGGVGPMTVATLIQNTLQACE 280
Cdd:PRK14193  240 KLVGD-VHPDVWEVAGAVSPNPGGVGPMTRAFLLTNVVERAE 280
PRK14174 PRK14174
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 5-285 4.66e-101

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 172662 [Multi-domain]  Cd Length: 295  Bit Score: 297.50  E-value: 4.66e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   5 IIDGKTIAQQVRSEVAEKVKARVAAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLELID 84
Cdd:PRK14174    3 IIDGKKVSLDLKNELKTRVEAYRAKTGKVPGLTVIIVGEDPASQVYVRNKAKSCKEIGMNSTVIELPADTTEEHLLKKIE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  85 TLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRL-------CqraprLRPCTPRGIVTLLERYNIDT 157
Cdd:PRK14174   83 DLNNDPDVHGILVQQPLPKQIDEFAVTLAIDPAKDVDGFHPENLGRLvmghldkC-----FVSCTPYGILELLGRYNIET 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 158 YGLNAVVIGASNIVGRPMS----MELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGIN 233
Cdd:PRK14174  158 KGKHCVVVGRSNIVGKPMAnlmlQKLKESNCTVTICHSATKDIPSYTRQADILIAAIGKARFITADMVKPGAVVIDVGIN 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1768216513 234 RLE-----SG-KVVGDVVYEDAAERASYITPVPGGVGPMTVATLIQNTLQACEEYHDV 285
Cdd:PRK14174  238 RIEdpstkSGyRLVGDVDYEGVSAKASAITPVPGGVGPMTIAMLLKNTLQSFERVNNL 295
PRK14182 PRK14182
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 5-277 3.20e-99

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 172670 [Multi-domain]  Cd Length: 282  Bit Score: 292.31  E-value: 3.20e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   5 IIDGKTIAQQVRSEVAEKVKARVAAGKrAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLELID 84
Cdd:PRK14182    3 LIDGKQIAAKVKGEVATEVRALAARGV-QTGLTVVRVGDDPASAIYVRGKRKDCEEVGITSVEHHLPATTTQAELLALIA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  85 TLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRL-RPCTPRGIVTLLERYNIDTYGLNAV 163
Cdd:PRK14182   82 RLNADPAVHGILVQLPLPKHVDERAVLDAISPAKDADGFHPFNVGALSIGIAGVpRPCTPAGVMRMLDEARVDPKGKRAL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 164 VIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKVVGD 243
Cdd:PRK14182  162 VVGRSNIVGKPMAMMLLERHATVTIAHSRTADLAGEVGRADILVAAIGKAELVKGAWVKEGAVVIDVGMNRLADGKLVGD 241

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1768216513 244 VVYEDAAERASYITPVPGGVGPMTVATLIQNTLQ 277
Cdd:PRK14182  242 VEFAAAAARASAITPVPGGVGPMTRAMLLVNTVE 275
PRK14167 PRK14167
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 3-286 2.35e-98

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 184549 [Multi-domain]  Cd Length: 297  Bit Score: 290.52  E-value: 2.35e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   3 AKIIDGKTIAQQVRSEVAEKVKARVAAGKRaPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLEL 82
Cdd:PRK14167    2 TEIIDGNAVAAQIRDDLTDAIETLEDAGVT-PGLATVLMSDDPASETYVSMKQRDCEEVGIEAIDVEIDPDAPAEELYDT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  83 IDTLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNA 162
Cdd:PRK14167   81 IDELNADEDVHGILVQMPVPDHVDDREVLRRIDPAKDVDGFHPENVGRLVAGDARFKPCTPHGIQKLLAAAGVDTEGADV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 163 VVIGASNIVGRPMSMELLLAG----CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESG 238
Cdd:PRK14167  161 VVVGRSDIVGKPMANLLIQKAdggnATVTVCHSRTDDLAAKTRRADIVVAAAGVPELIDGSMLSEGATVIDVGINRVDAD 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1768216513 239 -----KVVGDVVYEDAAERASYITPVPGGVGPMTVATLIQNTLQACEEYHDVE 286
Cdd:PRK14167  241 tekgyELVGDVEFESAKEKASAITPVPGGVGPMTRAMLLYNTVKAASLQEGVD 293
PRK14194 PRK14194
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 1-283 3.40e-98

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172682 [Multi-domain]  Cd Length: 301  Bit Score: 290.59  E-value: 3.40e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   1 MAAKIIDGKTIAQQVRSEVAEKVKARVAAGKRaPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELL 80
Cdd:PRK14194    2 MSAKLIDGKAAAARVLAQVREDVRTLKAAGIE-PALAVILVGNDPASQVYVRNKILRAEEAGIRSLEHRLPADTSQARLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  81 ELIDTLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGL 160
Cdd:PRK14194   81 ALIAELNADPSVNGILLQLPLPAHIDEARVLQAINPLKDVDGFHSENVGGLSQGRDVLTPCTPSGCLRLLEDTCGDLTGK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 161 NAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESG-- 238
Cdd:PRK14194  161 HAVVIGRSNIVGKPMAALLLQAHCSVTVVHSRSTDAKALCRQADIVVAAVGRPRLIDADWLKPGAVVIDVGINRIDDDgr 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1768216513 239 -KVVGDVVYEDAAERASYITPVPGGVGPMTVATLIQNTLQACEEYH 283
Cdd:PRK14194  241 sRLVGDVDFDSALPVVSAITPVPGGVGPMTIAFLMKNTVTAARLQA 286
PLN02616 PLN02616
tetrahydrofolate dehydrogenase/cyclohydrolase, putative
 2-286 1.34e-97

tetrahydrofolate dehydrogenase/cyclohydrolase, putative


Pssm-ID: 215332 [Multi-domain]  Cd Length: 364  Bit Score: 291.14  E-value: 1.34e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   2 AAKIIDGKTIAQQVRSEVAEKVKARVAAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLE 81
Cdd:PLN02616   72 GAKVIDGKAVAKKIRDEITIEVSRMKESIGVVPGLAVILVGDRKDSATYVRNKKKACDSVGINSFEVRLPEDSTEQEVLK 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  82 LIDTLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRA--PRLRPCTPRGIVTLLERYNIDTYG 159
Cdd:PLN02616  152 FISGFNNDPSVHGILVQLPLPSHMDEQNILNAVSIEKDVDGFHPLNIGRLAMRGrePLFVPCTPKGCIELLHRYNVEIKG 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 160 LNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESG- 238
Cdd:PLN02616  232 KRAVVIGRSNIVGMPAALLLQREDATVSIVHSRTKNPEEITREADIIISAVGQPNMVRGSWIKPGAVVIDVGINPVEDAs 311

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1768216513 239 -----KVVGDVVYEDAAERASYITPVPGGVGPMTVATLIQNTLQACEEYHDVE 286
Cdd:PLN02616  312 sprgyRLVGDVCYEEACKVASAVTPVPGGVGPMTIAMLLSNTLTSAKRIHNFQ 364
PRK14175 PRK14175
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 1-278 4.42e-97

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 184552 [Multi-domain]  Cd Length: 286  Bit Score: 287.20  E-value: 4.42e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   1 MAAKIIDGKTIAQQVRSEVAEKVKARVAAGkRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELL 80
Cdd:PRK14175    1 MVAKILDGKQIAKDYRQGLQDQVEALKEKG-FTPKLSVILVGNDGASQSYVRSKKKAAEKIGMISEIVHLEETATEEEVL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  81 ELIDTLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGL 160
Cdd:PRK14175   80 NELNRLNNDDSVSGILVQVPLPKQVSEQKILEAINPEKDVDGFHPINIGKLYIDEQTFVPCTPLGIMEILKHADIDLEGK 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 161 NAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKV 240
Cdd:PRK14175  160 NAVVIGRSHIVGQPVSKLLLQKNASVTILHSRSKDMASYLKDADVIVSAVGKPGLVTKDVVKEGAVIIDVGNTPDENGKL 239

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1768216513 241 VGDVVYEDAAERASYITPVPGGVGPMTVATLIQNTLQA 278
Cdd:PRK14175  240 KGDVDYDAVKEIAGAITPVPGGVGPLTITMVLNNTLLA 277
PRK14180 PRK14180
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 5-281 6.44e-97

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 172668 [Multi-domain]  Cd Length: 282  Bit Score: 286.54  E-value: 6.44e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   5 IIDGKTIAQQVRSEVAEKVKARVAAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLELID 84
Cdd:PRK14180    3 LIDGKSLSKDLKERLATQVQEYKHHTAITPKLVAIIVGNDPASKTYVASKEKACAQVGIDSQVITLPEHTTESELLELID 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  85 TLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPR-LRPCTPRGIVTLLERYNIDTYGLNAV 163
Cdd:PRK14180   83 QLNNDSSVHAILVQLPLPAHINKNNVIYSIKPEKDVDGFHPTNVGRLQLRDKKcLESCTPKGIMTMLREYGIKTEGAYAV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 164 VIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLEsGKVVGD 243
Cdd:PRK14180  163 VVGASNVVGKPVSQLLLNAKATVTTCHRFTTDLKSHTTKADILIVAVGKPNFITADMVKEGAVVIDVGINHVD-GKIVGD 241

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1768216513 244 VVYEDAAERASYITPVPGGVGPMTVATLIQNTLQACEE 281
Cdd:PRK14180  242 VDFAAVKDKVAAITPVPGGVGPMTITELLYNTFQCAQE 279
PLN02516 PLN02516
methylenetetrahydrofolate dehydrogenase (NADP+)
 3-276 1.96e-96

methylenetetrahydrofolate dehydrogenase (NADP+)


Pssm-ID: 178131 [Multi-domain]  Cd Length: 299  Bit Score: 286.02  E-value: 1.96e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   3 AKIIDGKTIAQQVRSEVAEKVKARVAAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLEL 82
Cdd:PLN02516    9 AQIIDGKAIAKAIRSEIAEEVAQLSEKHGKVPGLAVVIVGSRKDSQTYVNMKRKACAEVGIKSFDVDLPENISEAELISK 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  83 IDTLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQ--RAPRLRPCTPRGIVTLLERYNIDTYGL 160
Cdd:PLN02516   89 VHELNANPDVHGILVQLPLPKHINEEKILNEISLEKDVDGFHPLNIGKLAMkgREPLFLPCTPKGCLELLSRSGIPIKGK 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 161 NAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRL----- 235
Cdd:PLN02516  169 KAVVVGRSNIVGLPVSLLLLKADATVTVVHSRTPDPESIVREADIVIAAAGQAMMIKGDWIKPGAAVIDVGTNAVsdpsk 248

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1768216513 236 ESG-KVVGDVVYEDAAERASYITPVPGGVGPMTVATLIQNTL 276
Cdd:PLN02516  249 KSGyRLVGDVDFAEVSKVAGWITPVPGGVGPMTVAMLLKNTV 290
THF_DHG_CYH_C pfam02882
Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;
124-283 1.16e-95

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;


Pssm-ID: 427036  Cd Length: 160  Bit Score: 278.58  E-value: 1.16e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENA 203
Cdd:pfam02882   1 HPYNLGRLVLGKPCFVPCTPRGIMELLKRYGIDLAGKNVVVVGRSNIVGKPLALLLLNANATVTVCHSKTKDLAEITREA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 204 DLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKVVGDVVYEDAAERASYITPVPGGVGPMTVATLIQNTLQACEEYH 283
Cdd:pfam02882  81 DIVVVAVGKPELIKADWIKPGAVVIDVGINRVGNGKLVGDVDFENVKEKASAITPVPGGVGPMTVAMLLQNTVEAAKRQL 160
PRK14169 PRK14169
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 3-281 4.96e-95

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 184550 [Multi-domain]  Cd Length: 282  Bit Score: 281.83  E-value: 4.96e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   3 AKIIDGKTIAQQVRSEVAEKVkARVAAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLEL 82
Cdd:PRK14169    1 ATRLDGRAVSKKILADLKQTV-AKLAQQDVTPTLAVVLVGSDPASEVYVRNKQRRAEDIGVRSLMFRLPEATTQADLLAK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  83 IDTLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNA 162
Cdd:PRK14169   80 VAELNHDPDVDAILVQLPLPAGLDEQAVIDAIDPDKDVDGFSPVSVGRLWANEPTVVASTPYGIMALLDAYDIDVAGKRV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 163 VVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKVVG 242
Cdd:PRK14169  160 VIVGRSNIVGRPLAGLMVNHDATVTIAHSKTRNLKQLTKEADILVVAVGVPHFIGADAVKPGAVVIDVGISRGADGKLLG 239

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1768216513 243 DVVYEDAAERASYITPVPGGVGPMTVATLIQNTLQACEE 281
Cdd:PRK14169  240 DVDEAAVAPIASAITPVPGGVGPMTIASLMAQTVTLAKR 278
PRK14173 PRK14173
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 1-280 5.10e-95

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 184551 [Multi-domain]  Cd Length: 287  Bit Score: 281.72  E-value: 5.10e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   1 MAAKIIDGKTIAQQVRSEVaekvKARVAAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELL 80
Cdd:PRK14173    1 MAARELSGPPAAEAVYAEL----RARLAKLPFVPHLRVVRLGEDPASVSYVRLKDRQAKALGLRSQVEVLPESTSQEELL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  81 ELIDTLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGL 160
Cdd:PRK14173   77 ELIARLNADPEVDGILVQLPLPPHIDFQRVLEAIDPLKDVDGFHPLNVGRLWMGGEALEPCTPAGVVRLLKHYGIPLAGK 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 161 NAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRL--ESG 238
Cdd:PRK14173  157 EVVVVGRSNIVGKPLAALLLREDATVTLAHSKTQDLPAVTRRADVLVVAVGRPHLITPEMVRPGAVVVDVGINRVggNGG 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1768216513 239 K--VVGDVVYEdAAERASYITPVPGGVGPMTVATLIQNTLQACE 280
Cdd:PRK14173  237 RdiLTGDVHPE-VAEVAGALTPVPGGVGPMTVAMLMANTVIAAL 279
PRK14185 PRK14185
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 4-278 1.75e-94

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 184556 [Multi-domain]  Cd Length: 293  Bit Score: 280.56  E-value: 1.75e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   4 KIIDGKTIAQQVRSEVAEKVKARVAAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLELI 83
Cdd:PRK14185    2 QLIDGKAISAQIKQEIAAEVAEIVAKGGKRPHLAAILVGHDGGSETYVANKVKACEECGFKSSLIRYESDVTEEELLAKV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  84 DTLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNAV 163
Cdd:PRK14185   82 RELNQDDDVDGFIVQLPLPKHISEQKVIEAIDYRKDVDGFHPINVGRMSIGLPCFVSATPNGILELLKRYHIETSGKKCV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 164 VIGASNIVGRPMSMELLLAG----CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESG- 238
Cdd:PRK14185  162 VLGRSNIVGKPMAQLMMQKAypgdCTVTVCHSRSKNLKKECLEADIIIAALGQPEFVKADMVKEGAVVIDVGTTRVPDAt 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1768216513 239 -----KVVGDVVYEDAAERASYITPVPGGVGPMTVATLIQNTLQA 278
Cdd:PRK14185  242 rksgfKLTGDVKFDEVAPKCSYITPVPGGVGPMTIVSLMKNTLLA 286
PRK14178 PRK14178
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 5-278 1.95e-94

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172666 [Multi-domain]  Cd Length: 279  Bit Score: 280.19  E-value: 1.95e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   5 IIDGKTIAQQvRSEVaekVKARVAAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLELID 84
Cdd:PRK14178    2 ILDGKAVSEK-RLEL---LKEEIIESGLYPRLATVIVGDDPASQMYVRMKHRACERVGIGSVGIELPGDATTRTVLERIR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  85 TLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNAVV 164
Cdd:PRK14178   78 RLNEDPDINGILVQLPLPKGVDTERVIAAILPEKDVDGFHPLNLGRLVSGLPGFAPCTPNGIMTLLHEYKISIAGKRAVV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 165 IGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLEsGKVVGDV 244
Cdd:PRK14178  158 VGRSIDVGRPMAALLLNADATVTICHSKTENLKAELRQADILVSAAGKAGFITPDMVKPGATVIDVGINQVN-GKLCGDV 236

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1768216513 245 VYEDAAERASYITPVPGGVGPMTVATLIQNTLQA 278
Cdd:PRK14178  237 DFDAVKEIAGAITPVPGGVGPMTIATLMENTFDA 270
PRK14172 PRK14172
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 4-281 7.44e-94

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 172660 [Multi-domain]  Cd Length: 278  Bit Score: 278.59  E-value: 7.44e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   4 KIIDGKTIAQQVRSEVAEKVKARVAAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLELI 83
Cdd:PRK14172    3 QIINGKEVALKIKEEIKNFVEERKENGLSIPKIASILVGNDGGSIYYMNNQEKVANSLGIDFKKIKLDESISEEDLINEI 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  84 DTLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNAV 163
Cdd:PRK14172   83 EELNKDNNVHGIMLQLPLPKHLDEKKITNKIDANKDIDCLTFISVGKFYKGEKCFLPCTPNSVITLIKSLNIDIEGKEVV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 164 VIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLEsGKVVGD 243
Cdd:PRK14172  163 VIGRSNIVGKPVAQLLLNENATVTICHSKTKNLKEVCKKADILVVAIGRPKFIDEEYVKEGAIVIDVGTSSVN-GKITGD 241

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1768216513 244 VVYEDAAERASYITPVPGGVGPMTVATLIQNtlqACEE 281
Cdd:PRK14172  242 VNFDKVIDKASYITPVPGGVGSLTTTLLIKN---VCEA 276
PRK14177 PRK14177
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 1-282 2.63e-93

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172665 [Multi-domain]  Cd Length: 284  Bit Score: 277.24  E-value: 2.63e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   1 MAAKIIDGKTIAQQVRSEVAEKVKARVAAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELL 80
Cdd:PRK14177    1 MSPILLDGKKLSEKIRNEIRETIEERKTKNKRIPKLATILVGNNPASETYVSMKVKACHKVGMGSEMIRLKEQTTTEELL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  81 ELIDTLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGL 160
Cdd:PRK14177   81 GVIDKLNLDPNVDGILLQHPVPSQIDERAAFDRIALEKDVDGVTTLSFGKLSMGVETYLPCTPYGMVLLLKEYGIDVTGK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 161 NAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINrleSGKv 240
Cdd:PRK14177  161 NAVVVGRSPILGKPMAMLLTEMNATVTLCHSKTQNLPSIVRQADIIVGAVGKPEFIKADWISEGAVLLDAGYN---PGN- 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1768216513 241 VGDVVYEDAAERASYITPVPGGVGPMTVATLIQNTLQACEEY 282
Cdd:PRK14177  237 VGDIEISKAKDKSSFYTPVPGGVGPMTIAVLLLQTLYSFKEH 278
NAD_bind_m-THF_DH_Cyclohyd cd01080
NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NADP binding ...
 116-280 2.08e-90

NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NADP binding domain of the Methylene-Tetrahydrofolate Dehydrogenase/cyclohydrolase (m-THF DH/cyclohydrolase) bifunctional enzyme. Tetrahydrofolate is a versatile carrier of activated one-carbon units. The major one-carbon folate donors are N-5 methyltetrahydrofolate, N5,N10-m-THF, and N10-formayltetrahydrofolate. The oxidation of metabolic intermediate m-THF to m-THF requires the enzyme m-THF DH. In addition, most DHs also have an associated cyclohydrolase activity which catalyzes its hydrolysis to N10-formyltetrahydrofolate. m-THF DH is typically found as part of a multifunctional protein in eukaryotes. NADP-dependent m-THF DH in mammals, birds and yeast are components of a trifunctional enzyme with DH, cyclohydrolase, and synthetase activities. Certain eukaryotic cells also contain homodimeric bifunctional DH/cyclodrolase form. In bacteria, monofucntional DH, as well as bifunctional m-THF m-THF DHm-THF DHDH/cyclodrolase are found. In addition, yeast (S. cerevisiae) also express an monofunctional DH. This family contains the bifunctional DH/cyclohydrolase. M-THF DH, like other amino acid DH-like NAD(P)-binding domains, is a member of the Rossmann fold superfamily which includes glutamate, leucine, and phenylalanine DHs, m-THF DH, methylene-tetrahydromethanopterin DH, m-THF DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains.


Pssm-ID: 133448  Cd Length: 168  Bit Score: 265.57  E-value: 2.08e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 116 PDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKN 195
Cdd:cd01080     1 PEKDVDGLHPVNLGRLALGRPGFIPCTPAGILELLKRYGIDLAGKKVVVVGRSNIVGKPLAALLLNRNATVTVCHSKTKN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 196 LRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLE---SGKVVGDVVYEDAAERASYITPVPGGVGPMTVATLI 272
Cdd:cd01080    81 LKEHTKQADIVIVAVGKPGLVKGDMVKPGAVVIDVGINRVPdksGGKLVGDVDFESAKEKASAITPVPGGVGPMTVAMLM 160


                  ....*...
gi 1768216513 273 QNTLQACE 280
Cdd:cd01080   161 KNTVEAAK 168
PLN02897 PLN02897
tetrahydrofolate dehydrogenase/cyclohydrolase, putative
 3-284 2.28e-90

tetrahydrofolate dehydrogenase/cyclohydrolase, putative


Pssm-ID: 178485 [Multi-domain]  Cd Length: 345  Bit Score: 272.22  E-value: 2.28e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   3 AKIIDGKTIAQQVRSEVAEKVKARVAAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLEL 82
Cdd:PLN02897   56 TVVIDGNVIAEEIRTKIASEVRKMKKAVGKVPGLAVVLVGQQRDSQTYVRNKIKACEETGIKSLLAELPEDCTEGQILSA 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  83 IDTLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRA--PRLRPCTPRGIVTLLERYNIDTYGL 160
Cdd:PLN02897  136 LRKFNEDTSIHGILVQLPLPQHLDESKILNMVRLEKDVDGFHPLNVGNLAMRGrePLFVSCTPKGCVELLIRSGVEIAGK 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 161 NAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESG-- 238
Cdd:PLN02897  216 NAVVIGRSNIVGLPMSLLLQRHDATVSTVHAFTKDPEQITRKADIVIAAAGIPNLVRGSWLKPGAVVIDVGTTPVEDSsc 295

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1768216513 239 ----KVVGDVVYEDAAERASYITPVPGGVGPMTVATLIQNTLQACEEYHD 284
Cdd:PLN02897  296 efgyRLVGDVCYEEALGVASAITPVPGGVGPMTITMLLCNTLDAAKRIFL 345
PRK14187 PRK14187
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 5-278 3.12e-89

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172675 [Multi-domain]  Cd Length: 294  Bit Score: 267.46  E-value: 3.12e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   5 IIDGKTIAQQVRSEVAEKVKARVAAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLELID 84
Cdd:PRK14187    4 IIDGKKIANDITEILATCIDDLKRQHNLFPCLIVILVGDDPASQLYVRNKQRKAEMLGLRSETILLPSTISESSLIEKIN 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  85 TLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLC--QRAPRLRPCTPRGIVTLLERYNIDTYGLNA 162
Cdd:PRK14187   84 ELNNDDSVHGILVQLPVPNHIDKNLIINTIDPEKDVDGFHNENVGRLFtgQKKNCLIPCTPKGCLYLIKTITRNLSGSDA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 163 VVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESG---K 239
Cdd:PRK14187  164 VVIGRSNIVGKPMACLLLGENCTVTTVHSATRDLADYCSKADILVAAVGIPNFVKYSWIKKGAIVIDVGINSIEEGgvkK 243

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1768216513 240 VVGDVVYEDAAERASYITPVPGGVGPMTVATLIQNTLQA 278
Cdd:PRK14187  244 FVGDVDFAEVKKKASAITPVPGGVGPMTIAFLMVNTVIA 282
PRK14192 PRK14192
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 1-281 4.38e-89

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 184561 [Multi-domain]  Cd Length: 283  Bit Score: 266.71  E-value: 4.38e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   1 MAAKIIDGKTIAQQVRSEVAEKVKARVAAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELL 80
Cdd:PRK14192    1 MMALVLDGKALAKQIEEELSVRVEALKAKTGRTPILATILVGDDPASATYVRMKGNACRRVGMDSLKVELPQETTTEQLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  81 ELIDTLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGL 160
Cdd:PRK14192   81 AKIEELNANPDVHGILLQHPVPAQIDERACFDAISLAKDVDGVTCLGFGRMAMGEAAYGSATPAGIMRLLKAYNIELAGK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 161 NAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKv 240
Cdd:PRK14192  161 HAVVVGRSAILGKPMAMMLLNANATVTICHSRTQNLPELVKQADIIVGAVGKPELIKKDWIKQGAVVVDAGFHPRDGGG- 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1768216513 241 VGDVVYEDAAERASYITPVPGGVGPMTVATLIQNTLQACEE 281
Cdd:PRK14192  240 VGDIELQGIEEIASAYTPVPGGVGPMTINTLIRQTVEAAEK 280
PRK14168 PRK14168
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 1-278 1.84e-87

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 237633 [Multi-domain]  Cd Length: 297  Bit Score: 262.89  E-value: 1.84e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   1 MAAKIIDGKTIaqqvRSEVAEKVKARVAAGKR----APGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSE 76
Cdd:PRK14168    1 MSAKIIKGTEI----REEILEEIRGEVAELKEkygkVPGLVTILVGESPASLSYVTLKIKTAHRLGFHEIQDNQSVDITE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  77 AELLELIDTLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLC--QRAPRLRPCTPRGIVTLLERYN 154
Cdd:PRK14168   77 EELLALIDKYNNDDSIHGILVQLPLPKHINEKKVLNAIDPDKDVDGFHPVNVGRLMigGDEVKFLPCTPAGIQEMLVRSG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 155 IDTYGLNAVVIGASNIVGRPMSMELLLAG----CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDV 230
Cdd:PRK14168  157 VETSGAEVVVVGRSNIVGKPIANMMTQKGpganATVTIVHTRSKNLARHCQRADILIVAAGVPNLVKPEWIKPGATVIDV 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1768216513 231 GINRL----ESGKVV--GDVVYEDAAERASYITPVPGGVGPMTVATLIQNTLQA 278
Cdd:PRK14168  237 GVNRVgtneSTGKAIlsGDVDFDAVKEIAGKITPVPGGVGPMTIAMLMRNTLKS 290
PRK14170 PRK14170
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 3-280 1.83e-86

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172658 [Multi-domain]  Cd Length: 284  Bit Score: 260.01  E-value: 1.83e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   3 AKIIDGKTIAQQVRSEVAEKVKARVAAGKRaPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLEL 82
Cdd:PRK14170    2 GEIIDGKKLAKEIQEKVTREVAELVKEGKK-PGLAVVLVGDNQASRTYVRNKQKRTEEAGMKSVLIELPENVTEEKLLSV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  83 IDTLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNA 162
Cdd:PRK14170   81 VEELNEDKTIHGILVQLPLPEHISEEKVIDTISYDKDVDGFHPVNVGNLFIGKDSFVPCTPAGIIELIKSTGTQIEGKRA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 163 VVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKVVG 242
Cdd:PRK14170  161 VVIGRSNIVGKPVAQLLLNENATVTIAHSRTKDLPQVAKEADILVVATGLAKFVKKDYIKPGAIVIDVGMDRDENNKLCG 240

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1768216513 243 DVVYEDAAERASYITPVPGGVGPMTVATLIQNTLQACE 280
Cdd:PRK14170  241 DVDFDDVVEEAGFITPVPGGVGPMTITMLLANTLKAAK 278
PRK14171 PRK14171
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 5-278 4.30e-86

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172659 [Multi-domain]  Cd Length: 288  Bit Score: 259.12  E-value: 4.30e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   5 IIDGKTIAQQVRSEVAEKVKARVAAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLELID 84
Cdd:PRK14171    4 IIDGKALANEILADLKLEIQELKSQTNASPKLAIVLVGDNPASIIYVKNKIKNAHKIGIDTLLVNLSTTIHTNDLISKIN 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  85 TLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPR-LRPCTPRGIVTLLERYNIDTYGLNAV 163
Cdd:PRK14171   84 ELNLDNEISGIIVQLPLPSSIDKNKILSAVSPSKDIDGFHPLNVGYLHSGISQgFIPCTALGCLAVIKKYEPNLTGKNVV 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 164 VIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKVVGD 243
Cdd:PRK14171  164 IIGRSNIVGKPLSALLLKENCSVTICHSKTHNLSSITSKADIVVAAIGSPLKLTAEYFNPESIVIDVGINRISGNKIIGD 243

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1768216513 244 VVYEDAAERASYITPVPGGVGPMTVATLIQNTLQA 278
Cdd:PRK14171  244 VDFENVKSKVKYITPVPGGIGPMTIAFLLKNTVKA 278
PRK14181 PRK14181
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 15-275 3.50e-79

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172669 [Multi-domain]  Cd Length: 287  Bit Score: 241.69  E-value: 3.50e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  15 VRSEVAEKVKARVAAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADKTIDG 94
Cdd:PRK14181    8 AAEHILATIKENISASSTAPGLAVVLIGNDPASEVYVGMKVKKATDLGMVSKAHRLPSDATLSDILKLIHRLNNDPNIHG 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513  95 ILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGR-LCQRAPRLRPCTPRGIVTLLERYNIDTYGLNAVVIGASNIVGR 173
Cdd:PRK14181   88 ILVQLPLPKHLDAQAILQAISPDKDVDGLHPVNMGKlLLGETDGFIPCTPAGIIELLKYYEIPLHGRHVAIVGRSNIVGK 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 174 PMSMELLL----AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGK-----VVGDV 244
Cdd:PRK14181  168 PLAALLMQkhpdTNATVTLLHSQSENLTEILKTADIIIAAIGVPLFIKEEMIAEKAVIVDVGTSRVPAANpkgyiLVGDV 247

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1768216513 245 VYEDAAERASYITPVPGGVGPMTVATLIQNT 275
Cdd:PRK14181  248 DFNNVVPKCRAITPVPGGVGPMTVAMLMRNT 278
THF_DHG_CYH pfam00763
Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain;
6-121 5.10e-63

Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain;


Pssm-ID: 459930 [Multi-domain]  Cd Length: 115  Bit Score: 194.16  E-value: 5.10e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513   6 IDGKTIAQQVRSEVAEKVKARVAAGkRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLELIDT 85
Cdd:pfam00763   1 IDGKAIAKKIREELKEEVAALKAGG-RKPGLAVILVGDDPASQVYVRNKKKACEEVGIESELIRLPEDTTEEELLALIDK 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1768216513  86 LNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVD 121
Cdd:pfam00763  80 LNADPSVHGILVQLPLPKHIDEEKVLEAIDPEKDVD 115
NAD_bind_m-THF_DH_Cyclohyd_like cd05212
NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and ...
 140-280 3.73e-32

NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NAD(P) binding domains of methylene-tetrahydrofolate dehydrogenase (m-THF DH) and m-THF DH/cyclohydrolase bifunctional enzymes (m-THF DH/cyclohydrolase). M-THF is a versatile carrier of activated one-carbon units. The major one-carbon folate donors are N-5 methyltetrahydrofolate, N5,N10-m-THF, and N10-formayltetrahydrofolate. The oxidation of metabolic intermediate m-THF to m-THF requires the enzyme m-THF DH. In addition, most DHs also have an associated cyclohydrolase activity which catalyzes its hydrolysis to N10-formyltetrahydrofolate. m-THF DH is typically found as part of a multifunctional protein in eukaryotes. NADP-dependent m-THF DH in mammals, birds and yeast are components of a trifunctional enzyme with DH, cyclohydrolase, and synthetase activities. Certain eukaryotic cells also contain homodimeric bifunctional DH/cyclodrolase form. In bacteria, mono-functional DH, as well as bifunctional DH/cyclodrolase are found. In addition, yeast (S. cerevisiae) also express a monofunctional DH. M-THF DH, like other amino acid DH-like NAD(P)-binding domains, is a member of the Rossmann fold superfamily which includes glutamate, leucine, and phenylalanine DHs, m-THF DH, methylene-tetrahydromethanopterin DH, m-THF DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.


Pssm-ID: 133451  Cd Length: 140  Bit Score: 115.68  E-value: 3.73e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 140 PCTPRGIV-------TLLERYNIDTYGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGK 212
Cdd:cd05212     2 PCTPLFVSpvakavkELLNKEGVRLDGKKVLVVGRSGIVGAPLQCLLQRDGATVYSCDWKTIQLQSKVHDADVVVVGSPK 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1768216513 213 PGFIPGEWIKEGAIVVDVGINRLesgkvvgdvVYEDAAERASYITPVPGGVGPMTVATLIQNTLQACE 280
Cdd:cd05212    82 PEKVPTEWIKPGATVINCSPTKL---------SGDDVKESASLYVPMTGGVGKLTVAMRMQNMVRSVR 140
NAD_bind_m-THF_DH cd01079
NAD binding domain of methylene-tetrahydrofolate dehydrogenase; The NAD-binding domain of ...
 116-283 2.02e-13

NAD binding domain of methylene-tetrahydrofolate dehydrogenase; The NAD-binding domain of methylene-tetrahydrofolate dehydrogenase (m-THF DH). M-THF is a versatile carrier of activated one-carbon units. The major one-carbon folate donors are N-5 methyltetrahydrofolate, N5,N10-m-THF, and N10-formayltetrahydrofolate. The oxidation of metabolic intermediate m-THF to m-THF requires the enzyme m-THF DH. M-THF DH is a component of an unusual monofunctional enzyme; in eukaryotes, m-THF DH is typically found as part of a multifunctional protein. NADP-dependent m-THF DHs in mammals, birds and yeast are components of a trifunctional enzyme with DH, cyclohydrolase, and synthetase activities. Certain eukaryotic cells also contain homodimeric bifunctional DH/cyclodrolase form. In bacteria, monofunctional DH, as well as bifunctional DH/cyclodrolase are found. In addition, yeast (S. cerevisiae) also express an monofunctional DH. This family contains only the monofunctional DHs from S. cerevisiae and certain bacteria. M-THF DH, like other amino acid DH-like NAD(P)-binding domains, is a member of the Rossmann fold superfamily which includes glutamate, leucine, and phenylalanine DHs, m-THF DH, methylene-tetrahydromethanopterin DH, m-THF DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.


Pssm-ID: 133447 [Multi-domain]  Cd Length: 197  Bit Score: 67.45  E-value: 2.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 116 PDKDVDGFHPYNVGRLCQ---------RAPRLRPCTPRGIVTLLE---------RYNIDTYGLNAVVIGASNIVGRPMSM 177
Cdd:cd01079     1 PHKDVEGLSHKYIFNLYHnirfldpenRKKSILPCTPLAIVKILEflgiynkilPYGNRLYGKTITIINRSEVVGRPLAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 178 elLLAGCTTTV-------THRFTKN-----LRHHVEN-----------ADLLIVAVGKPGF-IPGEWIKEGAIVVDV-GI 232
Cdd:cd01079    81 --LLANDGARVysvdingIQVFTRGesirhEKHHVTDeeamtldclsqSDVVITGVPSPNYkVPTELLKDGAICINFaSI 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1768216513 233 NRLEsgkvvgdvvyEDAAERASYITPVpggVGPMTVATLIQNTLQACEEYH 283
Cdd:cd01079   159 KNFE----------PSVKEKASIYVPS---IGKVTIAMLLRNLLRLYHNQH 196
garR PRK11559
tartronate semialdehyde reductase; Provisional
 170-229 2.76e-03

tartronate semialdehyde reductase; Provisional


Pssm-ID: 183197 [Multi-domain]  Cd Length: 296  Bit Score: 38.49  E-value: 2.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768216513 170 IVGRPMSMELLLAGCTTTVTHRFTKNLRHHV--------------ENADLLI-----------VAVGKPGFIPGewIKEG 224
Cdd:PRK11559   12 IMGKPMSKNLLKAGYSLVVYDRNPEAVAEVIaagaetastakavaEQCDVIItmlpnsphvkeVALGENGIIEG--AKPG 89


                  ....*
gi 1768216513 225 AIVVD 229
Cdd:PRK11559   90 TVVID 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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