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Conserved domains on  [gi|1781451623|gb|KAE9410947|]
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cyclin-like protein [Gymnopus androsaceus JB14]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 19-169 6.45e-52

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410228  Cd Length: 150  Bit Score: 169.31  E-value: 6.45e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781451623  19 EASTQFKNWRY-SPDHLAHIRSTLNEAAVGVIRKTFEAYEPgsssNVSFVTADEEHLLVTFYIHKIGQLCGHFRFPEEVE 97
Cdd:cd20524     1 HTSTQRKHWIFsSEEELAELRAEANEKAREKLKESLKEEDA----EPKFLTPEEELLLVRYYEKKLLEFCRAFKLPDSVL 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1781451623  98 ATAASYLKRFYLKNTVMDWHPKNVMLTALFLATKTTNNPISLDAYTSHIPNTI--ASDVLDLEFLVAQSLRFEF 169
Cdd:cd20524    77 ATALTYFKRFYLKNSVMEYHPKEIMLTCLYLACKVEEFNISIDQFVGNIKESEktAEIILEYELLLLQGLNFHL 150
CYCLIN_CCNH_rpt2 cd20525
second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 172-304 4.06e-29

second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410229  Cd Length: 126  Bit Score: 109.30  E-value: 4.06e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781451623 172 WHAHRALWGIWLDIQNLPntPPDFAKTESAIYDSALTHVRAARLTDAEFIYTPSQIALACISLVAP---DLANQWLESKE 248
Cdd:cd20525     1 HHPYRPLEGFLLDLKTRL--PDLKAENLEKLYKEAREFLNRSLLTDAPLLYPPSQIALAALLLAASeagIDVEEYLSEKL 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1781451623 249 NtpipesrvDIPPRPSSTAISASLEAIRNMITNSGKVPHVEAVREVDKRLKLCKNP 304
Cdd:cd20525    79 P--------GSEESEELEKLLEIIREIKKLVKKYEGPPDKEEVKALDKKLKKCRNP 126
 
Name Accession Description Interval E-value
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 19-169 6.45e-52

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410228  Cd Length: 150  Bit Score: 169.31  E-value: 6.45e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781451623  19 EASTQFKNWRY-SPDHLAHIRSTLNEAAVGVIRKTFEAYEPgsssNVSFVTADEEHLLVTFYIHKIGQLCGHFRFPEEVE 97
Cdd:cd20524     1 HTSTQRKHWIFsSEEELAELRAEANEKAREKLKESLKEEDA----EPKFLTPEEELLLVRYYEKKLLEFCRAFKLPDSVL 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1781451623  98 ATAASYLKRFYLKNTVMDWHPKNVMLTALFLATKTTNNPISLDAYTSHIPNTI--ASDVLDLEFLVAQSLRFEF 169
Cdd:cd20524    77 ATALTYFKRFYLKNSVMEYHPKEIMLTCLYLACKVEEFNISIDQFVGNIKESEktAEIILEYELLLLQGLNFHL 150
ccl1 TIGR00569
cyclin ccl1; All proteins in this family for which functions are known are cyclins that are ...
 18-305 3.78e-45

cyclin ccl1; All proteins in this family for which functions are known are cyclins that are components of TFIIH, a complex that is involved in nucleotide excision repair and transcription initiation. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, StanfordUniversity). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129660 [Multi-domain]  Cd Length: 305  Bit Score: 156.92  E-value: 3.78e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781451623  18 YEASTQFKNWRYSP-DHLAHIRSTLNEAavgvIRKTFEAYEPGSSSNVSFVTADEEHLLVTFYIHKIGQLCGHFR--FPE 94
Cdd:TIGR00569   1 YRNSSQKRHWTFTSeEQLQEKRADANAK----FREAHEEEEKVLEAKPIFLTPEEELDLVKYYEKRLLDFCSAFKptMPT 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781451623  95 EVEATAASYLKRFYLKNTVMDWHPKNVMLTALFLATKTTNNPISLDAYTSHI---PNTIASDVLDLEFLVAQSLRFEFAV 171
Cdd:TIGR00569  77 SVVGTAIMYFKRFYLNNSVMEYHPKIIMLTCVFLACKVEEFNVSIDQFVGNLketPLKALEQVLEYELLLIQQLNFHLIV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781451623 172 WHAHRALWGIWLDIQN-LPNTP-PDFAKtesAIYDSALThvrAARLTDAEFIYTPSQIALACISLVAPDLANQwLESK-- 247
Cdd:TIGR00569 157 HNPYRPLEGFLIDIKTrLPGLEnPEYLR---KHADKFLN---RTLLTDAYLLYTPSQIALAAILHTASRAGLN-MESYlt 229

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1781451623 248 ENTPIPESRVDIPprpsstAISASLEAIRNMITNSGKvPHVEAVREVDKRLKLCKNPE 305
Cdd:TIGR00569 230 EQLSVPGNREELP------QLIDIMRELRILVKKYEE-PRSEKVAALKKKLDECHSIE 280
CYCLIN_CCNH_rpt2 cd20525
second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 172-304 4.06e-29

second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410229  Cd Length: 126  Bit Score: 109.30  E-value: 4.06e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781451623 172 WHAHRALWGIWLDIQNLPntPPDFAKTESAIYDSALTHVRAARLTDAEFIYTPSQIALACISLVAP---DLANQWLESKE 248
Cdd:cd20525     1 HHPYRPLEGFLLDLKTRL--PDLKAENLEKLYKEAREFLNRSLLTDAPLLYPPSQIALAALLLAASeagIDVEEYLSEKL 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1781451623 249 NtpipesrvDIPPRPSSTAISASLEAIRNMITNSGKVPHVEAVREVDKRLKLCKNP 304
Cdd:cd20525    79 P--------GSEESEELEKLLEIIREIKKLVKKYEGPPDKEEVKALDKKLKKCRNP 126
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 49-282 6.94e-25

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 102.50  E-value: 6.94e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781451623  49 IRKTFEAYEPgsssnvsFVTADEEHLLVTFYIHKIGQLCGHFRFPEEVEATAASYLKRFYLKNTVMDWHPKNVMLTALFL 128
Cdd:COG5333    25 IELDLLVLEP-------ELTLEKELNLVIYYLKLIMDLCTRLNLPQTVLATAILFFSRFYLKNSVEEISLYSVVTTCVYL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781451623 129 ATKTTNNP--ISLDAYTSHIPNT--IASD---VLDLEFLVAQSLRFEFAVWHAHRALWGIWLDIQNLpntppDFAKtesa 201
Cdd:COG5333    98 ACKVEDTPrdISIESFEARDLWSeePKSSrerILEYEFELLEALDFDLHVHHPYKYLEGFLKDLQEK-----DKYK---- 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781451623 202 IYDSALTHVRAARLTDAEFIYTPSQIALACIslvapdlanQWLESKENTPIPESRVDIPPRPSSTAISASLEAIR-NMIT 280
Cdd:COG5333   169 LLQIAWKIINDALRTDLCLLYPPHIIALAAL---------LIACEVLGMPIIKLLDFVSYETKEEVIALNYKSIVkNKIK 239


                  ..
gi 1781451623 281 NS 282
Cdd:COG5333   240 TF 241
Cyclin_C_2 pfam16899
Cyclin C-terminal domain; Cyclins contain two domains of similar all-alpha fold, this family ...
 173-279 5.44e-24

Cyclin C-terminal domain; Cyclins contain two domains of similar all-alpha fold, this family corresponds with the C-terminal domain of some cyclins including cyclin C and cyclin H.


Pssm-ID: 465303  Cd Length: 98  Bit Score: 94.53  E-value: 5.44e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781451623 173 HAHRALWGIWLDIQNLPntpPDFAKTESAIYDSALTHVRAARLTDAEFIYTPSQIALACISLVAPDLANQWLESKEntPI 252
Cdd:pfam16899   1 HPFRPLEGFLLDLKTRP---PLLEDRIESLYKRAREILKSALLTDAYFLYTPSQIALAALLLADSPLAEFYLTEKF--GL 75

                          90       100
                  ....*....|....*....|....*..
gi 1781451623 253 PESRVDIPPRpsstaISASLEAIRNMI 279
Cdd:pfam16899  76 PEDRETKLEK-----LLDTIESCRNLL 97
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 85-163 1.19e-10

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 57.22  E-value: 1.19e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1781451623   85 QLCGHFRFPEEVEATAASYLKRFYLKNTVMDWHPKNVMLTALFLATKTTNNPISLDAYTSHIPNTIASDVLDLEFLVAQ 163
Cdd:smart00385   5 RVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGYFTEEEILRMERLLLE 83
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 85-168 1.30e-03

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 38.27  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781451623  85 QLCGHFRFPEEVEATAASYLKRFYLKNTVmdwhPKN----VMLTALFLATKTTN-NPISLDAYTSHIPNTI-ASDVLDLE 158
Cdd:pfam00134  40 EVHEKFKLLPETLYLAVNYLDRFLSKKSV----PKNklqlVGVTCLFIAAKYEEiYPPTVEDLVYITDNAYtREEILRME 115

                          90
                  ....*....|
gi 1781451623 159 FLVAQSLRFE 168
Cdd:pfam00134 116 RLILETLNFD 125
 
Name Accession Description Interval E-value
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 19-169 6.45e-52

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410228  Cd Length: 150  Bit Score: 169.31  E-value: 6.45e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781451623  19 EASTQFKNWRY-SPDHLAHIRSTLNEAAVGVIRKTFEAYEPgsssNVSFVTADEEHLLVTFYIHKIGQLCGHFRFPEEVE 97
Cdd:cd20524     1 HTSTQRKHWIFsSEEELAELRAEANEKAREKLKESLKEEDA----EPKFLTPEEELLLVRYYEKKLLEFCRAFKLPDSVL 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1781451623  98 ATAASYLKRFYLKNTVMDWHPKNVMLTALFLATKTTNNPISLDAYTSHIPNTI--ASDVLDLEFLVAQSLRFEF 169
Cdd:cd20524    77 ATALTYFKRFYLKNSVMEYHPKEIMLTCLYLACKVEEFNISIDQFVGNIKESEktAEIILEYELLLLQGLNFHL 150
ccl1 TIGR00569
cyclin ccl1; All proteins in this family for which functions are known are cyclins that are ...
 18-305 3.78e-45

cyclin ccl1; All proteins in this family for which functions are known are cyclins that are components of TFIIH, a complex that is involved in nucleotide excision repair and transcription initiation. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, StanfordUniversity). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129660 [Multi-domain]  Cd Length: 305  Bit Score: 156.92  E-value: 3.78e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781451623  18 YEASTQFKNWRYSP-DHLAHIRSTLNEAavgvIRKTFEAYEPGSSSNVSFVTADEEHLLVTFYIHKIGQLCGHFR--FPE 94
Cdd:TIGR00569   1 YRNSSQKRHWTFTSeEQLQEKRADANAK----FREAHEEEEKVLEAKPIFLTPEEELDLVKYYEKRLLDFCSAFKptMPT 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781451623  95 EVEATAASYLKRFYLKNTVMDWHPKNVMLTALFLATKTTNNPISLDAYTSHI---PNTIASDVLDLEFLVAQSLRFEFAV 171
Cdd:TIGR00569  77 SVVGTAIMYFKRFYLNNSVMEYHPKIIMLTCVFLACKVEEFNVSIDQFVGNLketPLKALEQVLEYELLLIQQLNFHLIV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781451623 172 WHAHRALWGIWLDIQN-LPNTP-PDFAKtesAIYDSALThvrAARLTDAEFIYTPSQIALACISLVAPDLANQwLESK-- 247
Cdd:TIGR00569 157 HNPYRPLEGFLIDIKTrLPGLEnPEYLR---KHADKFLN---RTLLTDAYLLYTPSQIALAAILHTASRAGLN-MESYlt 229

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1781451623 248 ENTPIPESRVDIPprpsstAISASLEAIRNMITNSGKvPHVEAVREVDKRLKLCKNPE 305
Cdd:TIGR00569 230 EQLSVPGNREELP------QLIDIMRELRILVKKYEE-PRSEKVAALKKKLDECHSIE 280
CYCLIN_CCNH_rpt2 cd20525
second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 172-304 4.06e-29

second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410229  Cd Length: 126  Bit Score: 109.30  E-value: 4.06e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781451623 172 WHAHRALWGIWLDIQNLPntPPDFAKTESAIYDSALTHVRAARLTDAEFIYTPSQIALACISLVAP---DLANQWLESKE 248
Cdd:cd20525     1 HHPYRPLEGFLLDLKTRL--PDLKAENLEKLYKEAREFLNRSLLTDAPLLYPPSQIALAALLLAASeagIDVEEYLSEKL 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1781451623 249 NtpipesrvDIPPRPSSTAISASLEAIRNMITNSGKVPHVEAVREVDKRLKLCKNP 304
Cdd:cd20525    79 P--------GSEESEELEKLLEIIREIKKLVKKYEGPPDKEEVKALDKKLKKCRNP 126
CYCLIN_AcCycH_rpt1 cd20585
first cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; CycH ...
 18-168 1.31e-27

first cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; CycH associates with and activates the cyclin-dependent kinases, CDK-2 and CDK-3. CycH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410288  Cd Length: 170  Bit Score: 106.45  E-value: 1.31e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781451623  18 YEASTQFKNWRYSPDHLAHIRSTLNEAAVGVIRK--------------TFEAYEPGSSSNVSF----VTADEEHLLVTFY 79
Cdd:cd20585     2 FATSTHRQRWIFTPQDLTEKREAANQRAVDALQQcgatrveaqaagslGGGAEVGGSNGKAAKlpepLSADEELLMLKYY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781451623  80 IHKIGQLCGHFRFPEEVEATAASYLKRFYLKNTVMDWHPKNVMLTALFLATKTTNNPISldayTSHIPNTIASD---VLD 156
Cdd:cd20585    82 EQKIQEVCRALRLPNKIQATALLYFKRFYLQWSVMEHDPKRIMLTCIYLACKVEEYHVS----AEELGKGIQQDhqlILK 157

                         170
                  ....*....|..
gi 1781451623 157 LEFLVAQSLRFE 168
Cdd:cd20585   158 NELALLQGLNFD 169
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 49-282 6.94e-25

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 102.50  E-value: 6.94e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781451623  49 IRKTFEAYEPgsssnvsFVTADEEHLLVTFYIHKIGQLCGHFRFPEEVEATAASYLKRFYLKNTVMDWHPKNVMLTALFL 128
Cdd:COG5333    25 IELDLLVLEP-------ELTLEKELNLVIYYLKLIMDLCTRLNLPQTVLATAILFFSRFYLKNSVEEISLYSVVTTCVYL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781451623 129 ATKTTNNP--ISLDAYTSHIPNT--IASD---VLDLEFLVAQSLRFEFAVWHAHRALWGIWLDIQNLpntppDFAKtesa 201
Cdd:COG5333    98 ACKVEDTPrdISIESFEARDLWSeePKSSrerILEYEFELLEALDFDLHVHHPYKYLEGFLKDLQEK-----DKYK---- 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781451623 202 IYDSALTHVRAARLTDAEFIYTPSQIALACIslvapdlanQWLESKENTPIPESRVDIPPRPSSTAISASLEAIR-NMIT 280
Cdd:COG5333   169 LLQIAWKIINDALRTDLCLLYPPHIIALAAL---------LIACEVLGMPIIKLLDFVSYETKEEVIALNYKSIVkNKIK 239


                  ..
gi 1781451623 281 NS 282
Cdd:COG5333   240 TF 241
Cyclin_C_2 pfam16899
Cyclin C-terminal domain; Cyclins contain two domains of similar all-alpha fold, this family ...
 173-279 5.44e-24

Cyclin C-terminal domain; Cyclins contain two domains of similar all-alpha fold, this family corresponds with the C-terminal domain of some cyclins including cyclin C and cyclin H.


Pssm-ID: 465303  Cd Length: 98  Bit Score: 94.53  E-value: 5.44e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781451623 173 HAHRALWGIWLDIQNLPntpPDFAKTESAIYDSALTHVRAARLTDAEFIYTPSQIALACISLVAPDLANQWLESKEntPI 252
Cdd:pfam16899   1 HPFRPLEGFLLDLKTRP---PLLEDRIESLYKRAREILKSALLTDAYFLYTPSQIALAALLLADSPLAEFYLTEKF--GL 75

                          90       100
                  ....*....|....*....|....*..
gi 1781451623 253 PESRVDIPPRpsstaISASLEAIRNMI 279
Cdd:pfam16899  76 PEDRETKLEK-----LLDTIESCRNLL 97
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 85-163 1.19e-10

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 57.22  E-value: 1.19e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1781451623   85 QLCGHFRFPEEVEATAASYLKRFYLKNTVMDWHPKNVMLTALFLATKTTNNPISLDAYTSHIPNTIASDVLDLEFLVAQ 163
Cdd:smart00385   5 RVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGYFTEEEILRMERLLLE 83
CYCLIN_CCNC_rpt1 cd20513
first cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or ...
 78-165 2.73e-10

first cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or SRB11, is a component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. It mediates stress-induced mitochondrial fission and apoptosis. CCNC contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410217 [Multi-domain]  Cd Length: 101  Bit Score: 56.83  E-value: 2.73e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781451623  78 FYIHKIGQLCGHFRFPEEVEATAASYLKRFYLKNTVMDWHPKNVMLTALFLATKTTNNPI---SLDAYTSHIPNTI---- 150
Cdd:cd20513     4 FFANFIQALGERLKLRQRVIATAIVYFKRFYARNSFKDIDPRLVAPTCLYLASKVEECPSharLIVAEAKVLKTKFsyef 83

                          90
                  ....*....|....*...
gi 1781451623 151 ---ASDVLDLEFLVAQSL 165
Cdd:cd20513    84 pyrVNDILECEFYLLEAL 101
CYCLIN_AcCycH_rpt2 cd20586
second cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; ...
 172-304 1.57e-09

second cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; CycH associates with and activates the cyclin-dependent kinases, CDK-2 and CDK-3. CycH contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410289 [Multi-domain]  Cd Length: 132  Bit Score: 55.51  E-value: 1.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781451623 172 WHAHRALWGIWLDIQN-LPNTPPDFAKTESAIYDSALTHVRAARLTDAEFIYTPSQIALACI-----SLVAPDLAN--QW 243
Cdd:cd20586     1 YAPYRALEGFVQDLEEfLAAGSGPDSQGLQELRKAALAAVDKLMLTDAPLLYPPGQLALAALrsankAKGGVDFDRylER 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1781451623 244 LESKENTPIPEsrvdipprPSSTAISASLEAIRNMITNsGKVPHVEAVREVDKRLKLCKNP 304
Cdd:cd20586    81 VAARAASKMPD--------DPAAALTAVLDEIEYLVSE-GARPEVAEVKEIDRKLKECRAP 132
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 80-158 8.36e-09

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 52.03  E-value: 8.36e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1781451623  80 IHKIGQLCGHFRFPEEVEATAASYLKRFYLKNTVMDWHPKNVMLTALFLATKTTNNPISLDAYTSHIPNTIaSDVLDLE 158
Cdd:cd00043     3 VDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELPRTLKEIAKVSGVSE-KELRKAE 80
CYCLIN_ScCTK2-like_rpt1 cd20547
first cyclin box found in Saccharomyces cerevisiae CTD kinase subunit 2 (ScCTK2) and similar ...
 83-169 2.12e-08

first cyclin box found in Saccharomyces cerevisiae CTD kinase subunit 2 (ScCTK2) and similar proteins; CTK2, also called CTD kinase subunit beta, CTDK-I subunit beta, or CTD kinase 38 kDa subunit, is the cyclin subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. CTK2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410250 [Multi-domain]  Cd Length: 110  Bit Score: 51.58  E-value: 2.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781451623  83 IGQLCGHFRFPEEVEATAASYLKRFYLKNTVMDWHPKNVMLTALFLATKTTNNP-----ISLDAYTSHIPNTIASD---- 153
Cdd:cd20547     9 ISQLCKKLKFPRRTLGTAMLLYQRFHLFNPFTDSSNYEVALACLFLASKIEDTQkkskdILAASYNLRHPDKISVDdqml 88

                          90       100
                  ....*....|....*....|..
gi 1781451623 154 ------VLDLEFLVAQSLRFEF 169
Cdd:cd20547    89 eefrkaILGLERLLLETICFDF 110
CYCLIN_SpCG1C-like_rpt1 cd20545
first cyclin box found in Schizosaccharomyces pombe cyclin C homolog 1 (pch1) and similar ...
 91-132 2.90e-07

first cyclin box found in Schizosaccharomyces pombe cyclin C homolog 1 (pch1) and similar proteins; Cyclin pch1 is essential for progression through the whole cell cycle. It is a homolog of cyclin T; it forms a heterodimer with its partner kinase, cyclin-dependent kinase 9 (CDK9), that can phosphorylate both the pol II C-terminal domain (CTD) and the CTD of transcription elongation factor Spt5. Yeast Cdk9/Pch1, with mRNA capping enzyme Pct1, may also form an elongation checkpoint for mRNA quality control. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410248 [Multi-domain]  Cd Length: 116  Bit Score: 48.57  E-value: 2.90e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1781451623  91 RFPEEVEATAASYLKRFYLKNTVMDWHPKNVMLTALFLATKT 132
Cdd:cd20545    20 KLPQTTLFTAATYFHRFYMRNSLKKYHYYEIAATCLFLATKV 61
CYCLIN_AtCycC_rpt1 cd20571
first cyclin box found in Arabidopsis thaliana C-type cyclins (CycCs) and similar proteins; ...
 79-167 6.51e-05

first cyclin box found in Arabidopsis thaliana C-type cyclins (CycCs) and similar proteins; Plant CycCs are the cognate cyclin partners of cyclin-dependent kinase CDK8. They may be involved in cell cycle control. CycCs contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410274 [Multi-domain]  Cd Length: 107  Bit Score: 41.77  E-value: 6.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781451623  79 YIHKIGQlcgHFRFPEEVEATAASYLKRFYLKNTVMDWHPKNVMLTALFLATKTTNNPIS---LDAYTSHIPNTIA---- 151
Cdd:cd20571    13 YIKKLAQ---HIKVRQRVVATAITYFRRVYTRKSFTEYDPRLVAPTCLYLASKAEESTVQaklLVFYMKRLYADEYhrye 89

                          90
                  ....*....|....*..
gi 1781451623 152 -SDVLDLEFLVAQSLRF 167
Cdd:cd20571    90 iKDILEMEMKLLEALDY 106
CYCLIN_CCNM_CCNQ_rpt1 cd20534
first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ...
 72-139 3.40e-04

first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ancient conserved domain proteins (ACDPs), are evolutionarily conserved Mg2+ transporters. CCNM, also called cyclin-Q (CCNQ), or CDK10-activating cyclin, or cyclin-related protein FAM58A, associates with CDK10 to promote its kinase activity. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410237 [Multi-domain]  Cd Length: 110  Bit Score: 39.85  E-value: 3.40e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1781451623  72 EHLLVTFYIHKIGQLCghfRFPEEVEATAASYLKRFYLKNTVMDWHPKNVMLTALFLATKTTNNPISL 139
Cdd:cd20534     1 EHFKVLRFIREAGLKL---ELSSVTIATACVLYHRFYRELSLEDYDPYLVAMACLYLAGKAEEQPRRL 65
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 85-168 1.30e-03

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 38.27  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781451623  85 QLCGHFRFPEEVEATAASYLKRFYLKNTVmdwhPKN----VMLTALFLATKTTN-NPISLDAYTSHIPNTI-ASDVLDLE 158
Cdd:pfam00134  40 EVHEKFKLLPETLYLAVNYLDRFLSKKSV----PKNklqlVGVTCLFIAAKYEEiYPPTVEDLVYITDNAYtREEILRME 115

                          90
                  ....*....|
gi 1781451623 159 FLVAQSLRFE 168
Cdd:pfam00134 116 RLILETLNFD 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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