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Conserved domains on  [gi|1786751629|gb|KAF0127803|]
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methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [Elusimicrobia bacterium]

Protein Classification

bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase( domain architecture ID 11415140)

bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase reversibly catalyzes oxidation of 5,10-methylene-THF to 5,10-methenyl-THF and hydrolysis of 5,10-methenyl-THF to 10-formyl-THF

CATH:  3.40.50.720|3.40.430.10
EC:  1.5.1.5|3.5.4.9
Gene Ontology:  GO:0004488|GO:0003824|GO:0016787|GO:0009086|GO:0006164|GO:0006730
PubMed:  8485162
SCOP:  4000102

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FolD COG0190
5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase ...
 1-292 2.13e-114

5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism];


:

Pssm-ID: 439960 [Multi-domain]  Cd Length: 285  Bit Score: 331.21  E-value: 2.13e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   1 MADIIEGKTLSQSILADVAARAAAAAAAlGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIETHLIMPEESKGRDHFFG 80
Cdd:COG0190     2 MAQILDGKAVAAEIREELKERVAALKAK-GITPGLAVVLVGDDPASQVYVRNKHKACEEVGIESELIRLPADTTQEELLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  81 LLRELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLFLAKTwkeiaeggFFVPCTALAVVKIMKHA 160
Cdd:COG0190    81 LIDELNADPSVHGILVQLPLPKHIDEEAVLEAIDPEKDVDGFHPVNLGRLVLGEP--------GFVPCTPAGIMELLERY 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 161 GIDPAGKEIAVVGRSAIVGRPAAHMLTCLDATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGTN 240
Cdd:COG0190   153 GIDLAGKHAVVVGRSNIVGKPLALLLLRRNATVTVCHSRTKDLAEHTRQADILVAAVGKPGLITADMVKPGAVVIDVGIN 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1786751629 241 LGPDGKMCGDADSAALAGTAGRITPVPGGVGPVTLACLLEAAVTAAERRARE 292
Cdd:COG0190   233 RVEDGKLVGDVDFESVAEKASAITPVPGGVGPMTIAMLLENTLKAAERQAGL 284
 
Name Accession Description Interval E-value
FolD COG0190
5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase ...
 1-292 2.13e-114

5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism];


Pssm-ID: 439960 [Multi-domain]  Cd Length: 285  Bit Score: 331.21  E-value: 2.13e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   1 MADIIEGKTLSQSILADVAARAAAAAAAlGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIETHLIMPEESKGRDHFFG 80
Cdd:COG0190     2 MAQILDGKAVAAEIREELKERVAALKAK-GITPGLAVVLVGDDPASQVYVRNKHKACEEVGIESELIRLPADTTQEELLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  81 LLRELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLFLAKTwkeiaeggFFVPCTALAVVKIMKHA 160
Cdd:COG0190    81 LIDELNADPSVHGILVQLPLPKHIDEEAVLEAIDPEKDVDGFHPVNLGRLVLGEP--------GFVPCTPAGIMELLERY 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 161 GIDPAGKEIAVVGRSAIVGRPAAHMLTCLDATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGTN 240
Cdd:COG0190   153 GIDLAGKHAVVVGRSNIVGKPLALLLLRRNATVTVCHSRTKDLAEHTRQADILVAAVGKPGLITADMVKPGAVVIDVGIN 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1786751629 241 LGPDGKMCGDADSAALAGTAGRITPVPGGVGPVTLACLLEAAVTAAERRARE 292
Cdd:COG0190   233 RVEDGKLVGDVDFESVAEKASAITPVPGGVGPMTIAMLLENTLKAAERQAGL 284
PRK14190 PRK14190
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 1-290 2.10e-81

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 184560 [Multi-domain]  Cd Length: 284  Bit Score: 247.23  E-value: 2.10e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   1 MADIIEGKTLSQSILADVAARAAAAAAAlGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGI-ETHLIMPEESKGRDhFF 79
Cdd:PRK14190    2 MAVIIDGKEVAKEKREQLKEEVVKLKEQ-GIVPGLAVILVGDDPASHSYVRGKKKAAEKVGIySELYEFPADITEEE-LL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  80 GLLRELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLFLAKTwkeiaeggFFVPCTALAVVKIMKH 159
Cdd:PRK14190   80 ALIDRLNADPRINGILVQLPLPKHIDEKAVIERISPEKDVDGFHPINVGRMMLGQD--------TFLPCTPHGILELLKE 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 160 AGIDPAGKEIAVVGRSAIVGRPAAHMLTCLDATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGT 239
Cdd:PRK14190  152 YNIDISGKHVVVVGRSNIVGKPVGQLLLNENATVTYCHSKTKNLAELTKQADILIVAVGKPKLITADMVKEGAVVIDVGV 231

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1786751629 240 NLGPDGKMCGDADSAALAGTAGRITPVPGGVGPVTLACLLEAAVTAAERRA 290
Cdd:PRK14190  232 NRLENGKLCGDVDFDNVKEKASYITPVPGGVGPMTITMLMHNTVELAKRAG 282
NAD_bind_m-THF_DH_Cyclohyd cd01080
NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NADP binding ...
 115-287 5.21e-68

NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NADP binding domain of the Methylene-Tetrahydrofolate Dehydrogenase/cyclohydrolase (m-THF DH/cyclohydrolase) bifunctional enzyme. Tetrahydrofolate is a versatile carrier of activated one-carbon units. The major one-carbon folate donors are N-5 methyltetrahydrofolate, N5,N10-m-THF, and N10-formayltetrahydrofolate. The oxidation of metabolic intermediate m-THF to m-THF requires the enzyme m-THF DH. In addition, most DHs also have an associated cyclohydrolase activity which catalyzes its hydrolysis to N10-formyltetrahydrofolate. m-THF DH is typically found as part of a multifunctional protein in eukaryotes. NADP-dependent m-THF DH in mammals, birds and yeast are components of a trifunctional enzyme with DH, cyclohydrolase, and synthetase activities. Certain eukaryotic cells also contain homodimeric bifunctional DH/cyclodrolase form. In bacteria, monofucntional DH, as well as bifunctional m-THF m-THF DHm-THF DHDH/cyclodrolase are found. In addition, yeast (S. cerevisiae) also express an monofunctional DH. This family contains the bifunctional DH/cyclohydrolase. M-THF DH, like other amino acid DH-like NAD(P)-binding domains, is a member of the Rossmann fold superfamily which includes glutamate, leucine, and phenylalanine DHs, m-THF DH, methylene-tetrahydromethanopterin DH, m-THF DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains.


Pssm-ID: 133448  Cd Length: 168  Bit Score: 208.95  E-value: 5.21e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 115 PAKDPDALSTLNMGRLflaktwkeIAEGGFFVPCTALAVVKIMKHAGIDPAGKEIAVVGRSAIVGRPAAHMLTCLDATVT 194
Cdd:cd01080     1 PEKDVDGLHPVNLGRL--------ALGRPGFIPCTPAGILELLKRYGIDLAGKKVVVVGRSNIVGKPLAALLLNRNATVT 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 195 LCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGTNLGPD---GKMCGDADSAALAGTAGRITPVPGGVG 271
Cdd:cd01080    73 VCHSKTKNLKEHTKQADIVIVAVGKPGLVKGDMVKPGAVVIDVGINRVPDksgGKLVGDVDFESAKEKASAITPVPGGVG 152

                         170
                  ....*....|....*.
gi 1786751629 272 PVTLACLLEAAVTAAE 287
Cdd:cd01080   153 PMTVAMLMKNTVEAAK 168
THF_DHG_CYH_C pfam02882
Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;
123-290 8.38e-68

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;


Pssm-ID: 427036  Cd Length: 160  Bit Score: 208.09  E-value: 8.38e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 123 STLNMGRLFLAKTwkeiaeggFFVPCTALAVVKIMKHAGIDPAGKEIAVVGRSAIVGRPAAHMLTCLDATVTLCHSRTRD 202
Cdd:pfam02882   1 HPYNLGRLVLGKP--------CFVPCTPRGIMELLKRYGIDLAGKNVVVVGRSNIVGKPLALLLLNANATVTVCHSKTKD 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 203 INAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGTNLGPDGKMCGDADSAALAGTAGRITPVPGGVGPVTLACLLEAA 282
Cdd:pfam02882  73 LAEITREADIVVVAVGKPELIKADWIKPGAVVIDVGINRVGNGKLVGDVDFENVKEKASAITPVPGGVGPMTVAMLLQNT 152


                  ....*...
gi 1786751629 283 VTAAERRA 290
Cdd:pfam02882 153 VEAAKRQL 160
FolD_Thplmales NF041156
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 4-287 8.48e-61

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 469068 [Multi-domain]  Cd Length: 277  Bit Score: 194.27  E-value: 8.48e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   4 IIEGKTLSQSILADVAARAAAAAAALGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIETHLiMPEESKGRDHFFGLLR 83
Cdd:NF041156    2 ILDGEEIAEKKMERLKNEIEKIKNKYGIEPKLKLIQIGNDYASTIYANAKIRRGKKLGIDVDL-EKYDNITMDDLVKLIK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  84 ELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLFLAKTwkeiaeggFFVPCTALAVVKIMKHAGID 163
Cdd:NF041156   81 DYSADPDINGIMVESPLPKPINYYDIVKNIPYYKDVDGLSPYNQGNLYLKNE--------FIAPATARAVVDILDYYGIK 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 164 PAgkEIAVVGRSAIVGRPAAHMLTCLDATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGTNLgP 243
Cdd:NF041156  153 SG--NVCIINRSPVVGRPLSMMLLNRDYTVSVCHSKTVDIKEIARSSDIVVVAVGKPGFLDRSYVTDKSIVIDVGINY-V 229

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1786751629 244 DGKMCGDADSAALAGTAGRITPVPGGVGPVTLACLLEAAVTAAE 287
Cdd:NF041156  230 NNKICGDANFDNVSEKVKAITPVPGGVGPVTATDIFENFINGAK 273
 
Name Accession Description Interval E-value
FolD COG0190
5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase ...
 1-292 2.13e-114

5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism];


Pssm-ID: 439960 [Multi-domain]  Cd Length: 285  Bit Score: 331.21  E-value: 2.13e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   1 MADIIEGKTLSQSILADVAARAAAAAAAlGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIETHLIMPEESKGRDHFFG 80
Cdd:COG0190     2 MAQILDGKAVAAEIREELKERVAALKAK-GITPGLAVVLVGDDPASQVYVRNKHKACEEVGIESELIRLPADTTQEELLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  81 LLRELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLFLAKTwkeiaeggFFVPCTALAVVKIMKHA 160
Cdd:COG0190    81 LIDELNADPSVHGILVQLPLPKHIDEEAVLEAIDPEKDVDGFHPVNLGRLVLGEP--------GFVPCTPAGIMELLERY 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 161 GIDPAGKEIAVVGRSAIVGRPAAHMLTCLDATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGTN 240
Cdd:COG0190   153 GIDLAGKHAVVVGRSNIVGKPLALLLLRRNATVTVCHSRTKDLAEHTRQADILVAAVGKPGLITADMVKPGAVVIDVGIN 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1786751629 241 LGPDGKMCGDADSAALAGTAGRITPVPGGVGPVTLACLLEAAVTAAERRARE 292
Cdd:COG0190   233 RVEDGKLVGDVDFESVAEKASAITPVPGGVGPMTIAMLLENTLKAAERQAGL 284
PRK14190 PRK14190
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 1-290 2.10e-81

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 184560 [Multi-domain]  Cd Length: 284  Bit Score: 247.23  E-value: 2.10e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   1 MADIIEGKTLSQSILADVAARAAAAAAAlGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGI-ETHLIMPEESKGRDhFF 79
Cdd:PRK14190    2 MAVIIDGKEVAKEKREQLKEEVVKLKEQ-GIVPGLAVILVGDDPASHSYVRGKKKAAEKVGIySELYEFPADITEEE-LL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  80 GLLRELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLFLAKTwkeiaeggFFVPCTALAVVKIMKH 159
Cdd:PRK14190   80 ALIDRLNADPRINGILVQLPLPKHIDEKAVIERISPEKDVDGFHPINVGRMMLGQD--------TFLPCTPHGILELLKE 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 160 AGIDPAGKEIAVVGRSAIVGRPAAHMLTCLDATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGT 239
Cdd:PRK14190  152 YNIDISGKHVVVVGRSNIVGKPVGQLLLNENATVTYCHSKTKNLAELTKQADILIVAVGKPKLITADMVKEGAVVIDVGV 231

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1786751629 240 NLGPDGKMCGDADSAALAGTAGRITPVPGGVGPVTLACLLEAAVTAAERRA 290
Cdd:PRK14190  232 NRLENGKLCGDVDFDNVKEKASYITPVPGGVGPMTITMLMHNTVELAKRAG 282
PRK14189 PRK14189
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;
2-291 4.33e-78

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;


Pssm-ID: 184559 [Multi-domain]  Cd Length: 285  Bit Score: 238.82  E-value: 4.33e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   2 ADIIEGKTLSQSILADVAARAAAAAAAlGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIETHLIMPEESKGRDHFFGL 81
Cdd:PRK14189    3 AQLIDGNALSKQLRAEAAQRAAALTAR-GHQPGLAVILVGDNPASQVYVRNKVKACEDNGFHSLKDRYPADLSEAELLAR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  82 LRELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLFLAKTwkeiaeggFFVPCTALAVVKIMKHAG 161
Cdd:PRK14189   82 IDELNRDPKIHGILVQLPLPKHIDSHKVIEAIAPEKDVDGFHVANAGALMTGQP--------LFRPCTPYGVMKMLESIG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 162 IDPAGKEIAVVGRSAIVGRPAAHMLTCLDATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGTNL 241
Cdd:PRK14189  154 IPLRGAHAVVIGRSNIVGKPMAMLLLQAGATVTICHSKTRDLAAHTRQADIVVAAVGKRNVLTADMVKPGATVIDVGMNR 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1786751629 242 GPDGKMCGDADSAALAGTAGRITPVPGGVGPVTLACLLEAAVTAAERRAR 291
Cdd:PRK14189  234 DDAGKLCGDVDFAGVKEVAGYITPVPGGVGPMTITMLLVNTIEAAERAAA 283
PRK14186 PRK14186
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 1-290 6.58e-75

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 237636 [Multi-domain]  Cd Length: 297  Bit Score: 231.11  E-value: 6.58e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   1 MADIIEGKTLSQSILADVAARAAAAAAALGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIETHLIMPEESKGRDHFFG 80
Cdd:PRK14186    1 MALILDGKALAAEIEQRLQAQIESNLPKAGRPPGLAVLRVGDDPASAVYVRNKEKACARVGIASFGKHLPADTSQAEVEA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  81 LLRELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLFLAktwkeiaEGGFfVPCTALAVVKIMKHA 160
Cdd:PRK14186   81 LIAQLNQDERVDGILLQLPLPKHLDEVPLLHAIDPDKDADGLHPLNLGRLVKG-------EPGL-RSCTPAGVMRLLRSQ 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 161 GIDPAGKEIAVVGRSAIVGRPAAHMLTCLDATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGTN 240
Cdd:PRK14186  153 QIDIAGKKAVVVGRSILVGKPLALMLLAANATVTIAHSRTQDLASITREADILVAAAGRPNLIGAEMVKPGAVVVDVGIH 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1786751629 241 LGPD----GKMCGDADSAALAGTAGRITPVPGGVGPVTLACLLEAAVTAAERRA 290
Cdd:PRK14186  233 RLPSsdgkTRLCGDVDFEEVEPVAAAITPVPGGVGPMTVTMLLVNTVLSWQKRH 286
PRK14184 PRK14184
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 4-289 1.25e-74

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 237635 [Multi-domain]  Cd Length: 286  Bit Score: 230.05  E-value: 1.25e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   4 IIEGKTLSQSILADVAARAAAAAAALGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIETHLIMPEESKGRDHFFGLLR 83
Cdd:PRK14184    3 LLDGKATAATIREELKTEVAALTARHGRAPGLAVILVGEDPASQVYVRNKERACEDAGIVSEAFRLPADTTQEELEDLIA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  84 ELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLFLAKTWkeiaeggfFVPCTALAVVKIMKHAGID 163
Cdd:PRK14184   83 ELNARPDIDGILLQLPLPKGLDSQRCLELIDPAKDVDGFHPENMGRLALGLPG--------FRPCTPAGVMTLLERYGLS 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 164 PAGKEIAVVGRSAIVGRPAAHMLTCL----DATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGT 239
Cdd:PRK14184  155 PAGKKAVVVGRSNIVGKPLALMLGAPgkfaNATVTVCHSRTPDLAEECREADFLFVAIGRPRFVTADMVKPGAVVVDVGI 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1786751629 240 NLGPDGkMCGDADSAALAGTAGRITPVPGGVGPVTLACLLEAAVTAAERR 289
Cdd:PRK14184  235 NRTDDG-LVGDCDFEGLSDVASAITPVPGGVGPMTIAQLLVNTVQSWKER 283
PRK14191 PRK14191
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 4-294 3.78e-74

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172679 [Multi-domain]  Cd Length: 285  Bit Score: 228.88  E-value: 3.78e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   4 IIEGKTLSQSILADVAARAAAAAAALGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIETHLIMPEESKGRDHFFGLLR 83
Cdd:PRK14191    3 LLDGKALSYKIEKDLKNKIQILTAQTGKRPKLAVILVGKDPASQTYVNMKIKACERVGMDSDLHTLQENTTEAELLSLIK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  84 ELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLFLAKtwkeiaegGFFVPCTALAVVKIMKHAGID 163
Cdd:PRK14191   83 DLNTDQNIDGILVQLPLPRHIDTKMVLEAIDPNKDVDGFHPLNIGKLCSQL--------DGFVPATPMGVMRLLKHYHIE 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 164 PAGKEIAVVGRSAIVGRPAAHMLTCLDATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGTNLGP 243
Cdd:PRK14191  155 IKGKDVVIIGASNIVGKPLAMLMLNAGASVSVCHILTKDLSFYTQNADIVCVGVGKPDLIKASMVKKGAVVVDIGINRLN 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1786751629 244 DGKMCGDADSAALAGTAGRITPVPGGVGPVTLACLLEAAVTAAERRAREIK 294
Cdd:PRK14191  235 DGRLVGDVDFENVAPKASFITPVPGGVGPMTIVSLLENTLIAAEKRQRKGF 285
PRK10792 PRK10792
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 2-289 1.38e-70

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 236760 [Multi-domain]  Cd Length: 285  Bit Score: 219.79  E-value: 1.38e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   2 ADIIEGKTLSQSILADVAARAAAAAAALGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIETHLIMPEESKGRDHFFGL 81
Cdd:PRK10792    3 AKIIDGKTIAQQVRSEVAQKVQARVAAGLRAPGLAVVLVGSDPASQVYVASKRKACEEVGFVSRSYDLPETTSEAELLAL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  82 LRELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLFLAKTwkeiaeggFFVPCTALAVVKIMKHAG 161
Cdd:PRK10792   83 IDELNADPTIDGILVQLPLPAHIDNVKVLERIHPDKDVDGFHPYNVGRLAQRIP--------LLRPCTPRGIMTLLERYG 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 162 IDPAGKEIAVVGRSAIVGRPAAHMLTCLDATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGTNL 241
Cdd:PRK10792  155 IDTYGLNAVVVGASNIVGRPMSLELLLAGCTVTVCHRFTKNLRHHVRNADLLVVAVGKPGFIPGEWIKPGAIVIDVGINR 234

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1786751629 242 GPDGKMCGDADSAALAGTAGRITPVPGGVGPVTLACLLEAAVTAAERR 289
Cdd:PRK10792  235 LEDGKLVGDVEFETAAERASWITPVPGGVGPMTVATLLENTLQACEEY 282
NAD_bind_m-THF_DH_Cyclohyd cd01080
NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NADP binding ...
 115-287 5.21e-68

NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NADP binding domain of the Methylene-Tetrahydrofolate Dehydrogenase/cyclohydrolase (m-THF DH/cyclohydrolase) bifunctional enzyme. Tetrahydrofolate is a versatile carrier of activated one-carbon units. The major one-carbon folate donors are N-5 methyltetrahydrofolate, N5,N10-m-THF, and N10-formayltetrahydrofolate. The oxidation of metabolic intermediate m-THF to m-THF requires the enzyme m-THF DH. In addition, most DHs also have an associated cyclohydrolase activity which catalyzes its hydrolysis to N10-formyltetrahydrofolate. m-THF DH is typically found as part of a multifunctional protein in eukaryotes. NADP-dependent m-THF DH in mammals, birds and yeast are components of a trifunctional enzyme with DH, cyclohydrolase, and synthetase activities. Certain eukaryotic cells also contain homodimeric bifunctional DH/cyclodrolase form. In bacteria, monofucntional DH, as well as bifunctional m-THF m-THF DHm-THF DHDH/cyclodrolase are found. In addition, yeast (S. cerevisiae) also express an monofunctional DH. This family contains the bifunctional DH/cyclohydrolase. M-THF DH, like other amino acid DH-like NAD(P)-binding domains, is a member of the Rossmann fold superfamily which includes glutamate, leucine, and phenylalanine DHs, m-THF DH, methylene-tetrahydromethanopterin DH, m-THF DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains.


Pssm-ID: 133448  Cd Length: 168  Bit Score: 208.95  E-value: 5.21e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 115 PAKDPDALSTLNMGRLflaktwkeIAEGGFFVPCTALAVVKIMKHAGIDPAGKEIAVVGRSAIVGRPAAHMLTCLDATVT 194
Cdd:cd01080     1 PEKDVDGLHPVNLGRL--------ALGRPGFIPCTPAGILELLKRYGIDLAGKKVVVVGRSNIVGKPLAALLLNRNATVT 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 195 LCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGTNLGPD---GKMCGDADSAALAGTAGRITPVPGGVG 271
Cdd:cd01080    73 VCHSKTKNLKEHTKQADIVIVAVGKPGLVKGDMVKPGAVVIDVGINRVPDksgGKLVGDVDFESAKEKASAITPVPGGVG 152

                         170
                  ....*....|....*.
gi 1786751629 272 PVTLACLLEAAVTAAE 287
Cdd:cd01080   153 PMTVAMLMKNTVEAAK 168
THF_DHG_CYH_C pfam02882
Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;
123-290 8.38e-68

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;


Pssm-ID: 427036  Cd Length: 160  Bit Score: 208.09  E-value: 8.38e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 123 STLNMGRLFLAKTwkeiaeggFFVPCTALAVVKIMKHAGIDPAGKEIAVVGRSAIVGRPAAHMLTCLDATVTLCHSRTRD 202
Cdd:pfam02882   1 HPYNLGRLVLGKP--------CFVPCTPRGIMELLKRYGIDLAGKNVVVVGRSNIVGKPLALLLLNANATVTVCHSKTKD 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 203 INAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGTNLGPDGKMCGDADSAALAGTAGRITPVPGGVGPVTLACLLEAA 282
Cdd:pfam02882  73 LAEITREADIVVVAVGKPELIKADWIKPGAVVIDVGINRVGNGKLVGDVDFENVKEKASAITPVPGGVGPMTVAMLLQNT 152


                  ....*...
gi 1786751629 283 VTAAERRA 290
Cdd:pfam02882 153 VEAAKRQL 160
PRK14173 PRK14173
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 2-290 1.90e-67

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 184551 [Multi-domain]  Cd Length: 287  Bit Score: 211.61  E-value: 1.90e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   2 ADIIEGKTLSQSILADVAARAAAaaaaLGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIETHLIMPEESKGRDHFFGL 81
Cdd:PRK14173    3 ARELSGPPAAEAVYAELRARLAK----LPFVPHLRVVRLGEDPASVSYVRLKDRQAKALGLRSQVEVLPESTSQEELLEL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  82 LRELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLFLAktwkeiaeGGFFVPCTALAVVKIMKHAG 161
Cdd:PRK14173   79 IARLNADPEVDGILVQLPLPPHIDFQRVLEAIDPLKDVDGFHPLNVGRLWMG--------GEALEPCTPAGVVRLLKHYG 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 162 IDPAGKEIAVVGRSAIVGRPAAHMLTCLDATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGTN- 240
Cdd:PRK14173  151 IPLAGKEVVVVGRSNIVGKPLAALLLREDATVTLAHSKTQDLPAVTRRADVLVVAVGRPHLITPEMVRPGAVVVDVGINr 230

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1786751629 241 -LGPDGKMCGDADSA-ALAGTAGRITPVPGGVGPVTLACLLEAAVTAAERRA 290
Cdd:PRK14173  231 vGGNGGRDILTGDVHpEVAEVAGALTPVPGGVGPMTVAMLMANTVIAALRRR 282
PRK14188 PRK14188
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 1-290 2.58e-67

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 184558 [Multi-domain]  Cd Length: 296  Bit Score: 211.74  E-value: 2.58e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   1 MADIIEGKTLSQSILADVAARAAAAAAALGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIETHLIMPEESKGRDHFFG 80
Cdd:PRK14188    1 MATIIDGKAFAADVRATVAAEVARLKAAHGVTPGLAVVLVGEDPASQVYVRSKGKQTKEAGMASFEHKLPADTSQAELLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  81 LLRELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLflaktwkeiAEGGF-FVPCTALAVVKIMKH 159
Cdd:PRK14188   81 LIARLNADPAIHGILVQLPLPKHLDSEAVIQAIDPEKDVDGLHVVNAGRL---------ATGETaLVPCTPLGCMMLLRR 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 160 AGIDPAGKEIAVVGRSAIVGRPAAHMLTCLDATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGT 239
Cdd:PRK14188  152 VHGDLSGLNAVVIGRSNLVGKPMAQLLLAANATVTIAHSRTRDLPAVCRRADILVAAVGRPEMVKGDWIKPGATVIDVGI 231

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1786751629 240 NLGP-----DGK--MCGDADSAALAGTAGRITPVPGGVGPVTLACLLEAAVTAAERRA 290
Cdd:PRK14188  232 NRIPapekgEGKtrLVGDVAFAEAAEVAGAITPVPGGVGPMTIACLLANTLTAACRAA 289
PRK14193 PRK14193
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 1-291 3.74e-67

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 237637 [Multi-domain]  Cd Length: 284  Bit Score: 211.03  E-value: 3.74e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   1 MADIIEGKTLSQSILADVAARAAAAAAAlGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIET-HLIMPEESKgRDHFF 79
Cdd:PRK14193    2 TAIILDGKATADEIKADLAERVAALKEK-GITPGLGTVLVGDDPGSQAYVRGKHRDCAEVGITSiRRDLPADAT-QEELN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  80 GLLRELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLFLAKTWKeiaeggffVPCTALAVVKIMKH 159
Cdd:PRK14193   80 AVIDELNADPACTGYIVQLPLPKHLDENAVLERIDPAKDADGLHPTNLGRLVLNEPAP--------LPCTPRGIVHLLRR 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 160 AGIDPAGKEIAVVGRSAIVGRPAAHMLT--CLDATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDV 237
Cdd:PRK14193  152 YDVELAGAHVVVIGRGVTVGRPIGLLLTrrSENATVTLCHTGTRDLAAHTRRADIIVAAAGVAHLVTADMVKPGAAVLDV 231

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1786751629 238 GTNLGPDGKMCGDADSAAlAGTAGRITPVPGGVGPVTLACLLEAAVTAAERRAR 291
Cdd:PRK14193  232 GVSRAGDGKLVGDVHPDV-WEVAGAVSPNPGGVGPMTRAFLLTNVVERAERRAG 284
PRK14166 PRK14166
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 4-289 7.35e-65

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 172654 [Multi-domain]  Cd Length: 282  Bit Score: 204.87  E-value: 7.35e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   4 IIEGKTLSQSILADVAARAAAAAAAlGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIETHLIMPEESKGRDHFFGLLR 83
Cdd:PRK14166    3 LLDGKALSAKIKEELKEKNQFLKSK-GIESCLAVILVGDNPASQTYVKSKAKACEECGIKSLVYHLNENTTQNELLALIN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  84 ELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLFLAktwkeiAEGGFfVPCTALAVVKIMKHAGID 163
Cdd:PRK14166   82 TLNHDDSVHGILVQLPLPDHICKDLILESIISSKDVDGFHPINVGYLNLG------LESGF-LPCTPLGVMKLLKAYEID 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 164 PAGKEIAVVGRSAIVGRPAAHMLTCLDATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGTNLGP 243
Cdd:PRK14166  155 LEGKDAVIIGASNIVGRPMATMLLNAGATVSVCHIKTKDLSLYTRQADLIIVAAGCVNLLRSDMVKEGVIVVDVGINRLE 234

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1786751629 244 DGKMCGDADSAALAGTAGRITPVPGGVGPVTLACLLEAAVTAAERR 289
Cdd:PRK14166  235 SGKIVGDVDFEEVSKKSSYITPVPGGVGPMTIAMLLENTVKSAKNR 280
PRK14169 PRK14169
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 2-291 1.05e-64

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 184550 [Multi-domain]  Cd Length: 282  Bit Score: 204.41  E-value: 1.05e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   2 ADIIEGKTLSQSILADVAARAAAAAAAlGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIETHLI-MPEESKGRDhFFG 80
Cdd:PRK14169    1 ATRLDGRAVSKKILADLKQTVAKLAQQ-DVTPTLAVVLVGSDPASEVYVRNKQRRAEDIGVRSLMFrLPEATTQAD-LLA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  81 LLRELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLFLAKTWkeiaeggfFVPCTALAVVKIMKHA 160
Cdd:PRK14169   79 KVAELNHDPDVDAILVQLPLPAGLDEQAVIDAIDPDKDVDGFSPVSVGRLWANEPT--------VVASTPYGIMALLDAY 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 161 GIDPAGKEIAVVGRSAIVGRPAAHMLTCLDATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGTN 240
Cdd:PRK14169  151 DIDVAGKRVVIVGRSNIVGRPLAGLMVNHDATVTIAHSKTRNLKQLTKEADILVVAVGVPHFIGADAVKPGAVVIDVGIS 230

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1786751629 241 LGPDGKMCGDADSAALAGTAGRITPVPGGVGPVTLACLLEAAVTAAERRAR 291
Cdd:PRK14169  231 RGADGKLLGDVDEAAVAPIASAITPVPGGVGPMTIASLMAQTVTLAKRRAN 281
PRK14172 PRK14172
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 1-279 1.37e-64

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 172660 [Multi-domain]  Cd Length: 278  Bit Score: 204.24  E-value: 1.37e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   1 MADIIEGKTLSQSILADVAARAAAAAAALGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIETHLIMPEESKGRDHFFG 80
Cdd:PRK14172    1 MGQIINGKEVALKIKEEIKNFVEERKENGLSIPKIASILVGNDGGSIYYMNNQEKVANSLGIDFKKIKLDESISEEDLIN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  81 LLRELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLFLAKTWkeiaeggfFVPCTALAVVKIMKHA 160
Cdd:PRK14172   81 EIEELNKDNNVHGIMLQLPLPKHLDEKKITNKIDANKDIDCLTFISVGKFYKGEKC--------FLPCTPNSVITLIKSL 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 161 GIDPAGKEIAVVGRSAIVGRPAAHMLTCLDATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGTN 240
Cdd:PRK14172  153 NIDIEGKEVVVIGRSNIVGKPVAQLLLNENATVTICHSKTKNLKEVCKKADILVVAIGRPKFIDEEYVKEGAIVIDVGTS 232

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1786751629 241 LgPDGKMCGDADSAALAGTAGRITPVPGGVGPVTLACLL 279
Cdd:PRK14172  233 S-VNGKITGDVNFDKVIDKASYITPVPGGVGSLTTTLLI 270
PRK14179 PRK14179
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;
1-292 4.62e-64

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;


Pssm-ID: 237634 [Multi-domain]  Cd Length: 284  Bit Score: 203.06  E-value: 4.62e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   1 MADIIEGKTLSQSILADVAARAAAAAAALGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIETHLIMPEESKGRDHFFG 80
Cdd:PRK14179    1 MTEIIDGKALAQKMQAELAEKVAKLKEEKGIVPGLVVILVGDNPASQVYVRNKERSALAAGFKSEVVRLPETISQEELLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  81 LLRELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLFLAKTwkeiaeggFFVPCTALAVVKIMKHA 160
Cdd:PRK14179   81 LIERYNQDPTWHGILVQLPLPKHINEEKILLAIDPKKDVDGFHPMNTGHLWSGRP--------VMIPCTPAGIMEMFREY 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 161 GIDPAGKEIAVVGRSAIVGRPAAHMLTCLDATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGTN 240
Cdd:PRK14179  153 NVELEGKHAVVIGRSNIVGKPMAQLLLDKNATVTLTHSRTRNLAEVARKADILVVAIGRGHFVTKEFVKEGAVVIDVGMN 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1786751629 241 LGPDGKMCGDADSAALAGTAGRITPVPGGVGPVTLACLLEAAVTAAERRARE 292
Cdd:PRK14179  233 RDENGKLIGDVDFDEVAEVASYITPVPGGVGPMTITMLMEQTYQAALRSLHK 284
PRK14175 PRK14175
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 30-289 1.49e-63

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 184552 [Multi-domain]  Cd Length: 286  Bit Score: 201.68  E-value: 1.49e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  30 GRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIETHLIMPEESKGRDHFFGLLRELGADNAVDAIMVERPLPKGFDAPEA 109
Cdd:PRK14175   30 GFTPKLSVILVGNDGASQSYVRSKKKAAEKIGMISEIVHLEETATEEEVLNELNRLNNDDSVSGILVQVPLPKQVSEQKI 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 110 WELLDPAKDPDALSTLNMGRLFLAKTwkeiaeggFFVPCTALAVVKIMKHAGIDPAGKEIAVVGRSAIVGRPAAHMLTCL 189
Cdd:PRK14175  110 LEAINPEKDVDGFHPINIGKLYIDEQ--------TFVPCTPLGIMEILKHADIDLEGKNAVVIGRSHIVGQPVSKLLLQK 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 190 DATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGTNLGPDGKMCGDADSAALAGTAGRITPVPGG 269
Cdd:PRK14175  182 NASVTILHSRSKDMASYLKDADVIVSAVGKPGLVTKDVVKEGAVIIDVGNTPDENGKLKGDVDYDAVKEIAGAITPVPGG 261

                         250       260
                  ....*....|....*....|
gi 1786751629 270 VGPVTLACLLEAAVTAAERR 289
Cdd:PRK14175  262 VGPLTITMVLNNTLLAEKMR 281
PRK14178 PRK14178
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 30-289 3.82e-63

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172666 [Multi-domain]  Cd Length: 279  Bit Score: 200.45  E-value: 3.82e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  30 GRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIETHLI-MPEESKGRDhFFGLLRELGADNAVDAIMVERPLPKGFDAPE 108
Cdd:PRK14178   24 GLYPRLATVIVGDDPASQMYVRMKHRACERVGIGSVGIeLPGDATTRT-VLERIRRLNEDPDINGILVQLPLPKGVDTER 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 109 AWELLDPAKDPDALSTLNMGRLFLAKTwkeiaeggFFVPCTALAVVKIMKHAGIDPAGKEIAVVGRSAIVGRPAAHMLTC 188
Cdd:PRK14178  103 VIAAILPEKDVDGFHPLNLGRLVSGLP--------GFAPCTPNGIMTLLHEYKISIAGKRAVVVGRSIDVGRPMAALLLN 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 189 LDATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGTNlGPDGKMCGDADSAALAGTAGRITPVPG 268
Cdd:PRK14178  175 ADATVTICHSKTENLKAELRQADILVSAAGKAGFITPDMVKPGATVIDVGIN-QVNGKLCGDVDFDAVKEIAGAITPVPG 253

                         250       260
                  ....*....|....*....|.
gi 1786751629 269 GVGPVTLACLLEAAVTAAERR 289
Cdd:PRK14178  254 GVGPMTIATLMENTFDAAKMR 274
PRK14174 PRK14174
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 4-288 9.90e-63

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 172662 [Multi-domain]  Cd Length: 295  Bit Score: 200.05  E-value: 9.90e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   4 IIEGKTLSQSILADVAARAAAAAAALGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIETHLIMPEESKGRDHFFGLLR 83
Cdd:PRK14174    3 IIDGKKVSLDLKNELKTRVEAYRAKTGKVPGLTVIIVGEDPASQVYVRNKAKSCKEIGMNSTVIELPADTTEEHLLKKIE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  84 ELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLFLAKTWKeiaeggFFVPCTALAVVKIMKHAGID 163
Cdd:PRK14174   83 DLNNDPDVHGILVQQPLPKQIDEFAVTLAIDPAKDVDGFHPENLGRLVMGHLDK------CFVSCTPYGILELLGRYNIE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 164 PAGKEIAVVGRSAIVGRPAAH-MLTCLDA---TVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGT 239
Cdd:PRK14174  157 TKGKHCVVVGRSNIVGKPMANlMLQKLKEsncTVTICHSATKDIPSYTRQADILIAAIGKARFITADMVKPGAVVIDVGI 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1786751629 240 NLGPDG------KMCGDADSAALAGTAGRITPVPGGVGPVTLACLLEAAVTAAER 288
Cdd:PRK14174  237 NRIEDPstksgyRLVGDVDYEGVSAKASAITPVPGGVGPMTIAMLLKNTLQSFER 291
PRK14176 PRK14176
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 4-288 2.89e-62

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 184553 [Multi-domain]  Cd Length: 287  Bit Score: 198.49  E-value: 2.89e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   4 IIEGKTLSQSILADVAARAAAAAAALGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIETHLIMPEESKGRDHFFGLLR 83
Cdd:PRK14176   10 IIDGKALAKKIEAEVRSGVERLKSNRGITPGLATILVGDDPASKMYVRLKHKACERVGIRAEDQFLPADTTQEELLELID 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  84 ELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLFLAktwkeiAEGgfFVPCTALAVVKIMKHAGID 163
Cdd:PRK14176   90 SLNKRKDVHGILLQLPLPKHLDPQEAMEAIDPAKDADGFHPYNMGKLMIG------DEG--LVPCTPHGVIRALEEYGVD 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 164 PAGKEIAVVGRSAIVGRPAAHMLTCLDATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGTNlGP 243
Cdd:PRK14176  162 IEGKNAVIVGHSNVVGKPMAAMLLNRNATVSVCHVFTDDLKKYTLDADILVVATGVKHLIKADMVKEGAVIFDVGIT-KE 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1786751629 244 DGKMCGDADSAALAGTAGRITPVPGGVGPVTLACLLEAAVTAAER 288
Cdd:PRK14176  241 EDKVYGDVDFENVIKKASLITPVPGGVGPLTIAMLMKHVLMCAEK 285
FolD_Thplmales NF041156
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 4-287 8.48e-61

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 469068 [Multi-domain]  Cd Length: 277  Bit Score: 194.27  E-value: 8.48e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   4 IIEGKTLSQSILADVAARAAAAAAALGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIETHLiMPEESKGRDHFFGLLR 83
Cdd:NF041156    2 ILDGEEIAEKKMERLKNEIEKIKNKYGIEPKLKLIQIGNDYASTIYANAKIRRGKKLGIDVDL-EKYDNITMDDLVKLIK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  84 ELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLFLAKTwkeiaeggFFVPCTALAVVKIMKHAGID 163
Cdd:NF041156   81 DYSADPDINGIMVESPLPKPINYYDIVKNIPYYKDVDGLSPYNQGNLYLKNE--------FIAPATARAVVDILDYYGIK 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 164 PAgkEIAVVGRSAIVGRPAAHMLTCLDATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGTNLgP 243
Cdd:NF041156  153 SG--NVCIINRSPVVGRPLSMMLLNRDYTVSVCHSKTVDIKEIARSSDIVVVAVGKPGFLDRSYVTDKSIVIDVGINY-V 229

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1786751629 244 DGKMCGDADSAALAGTAGRITPVPGGVGPVTLACLLEAAVTAAE 287
Cdd:NF041156  230 NNKICGDANFDNVSEKVKAITPVPGGVGPVTATDIFENFINGAK 273
PRK14183 PRK14183
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 4-290 2.30e-60

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 184555 [Multi-domain]  Cd Length: 281  Bit Score: 193.51  E-value: 2.30e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   4 IIEGKTLSQSILADVAARAAAAAAALGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIETHLIMPEESKGRDHFFGLLR 83
Cdd:PRK14183    3 ILDGKALSDKIKENVKKEVDELKLVKNIVPGLAVILVGDDPASHTYVKMKAKACDRVGIYSITHEMPSTISQKEILETIA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  84 ELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLflaktwkeiAEG-GFFVPCTALAVVKIMKHAGI 162
Cdd:PRK14183   83 MMNNNPNIDGILVQLPLPKHIDTTKILEAIDPKKDVDGFHPYNVGRL---------VTGlDGFVPCTPLGVMELLEEYEI 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 163 DPAGKEIAVVGRSAIVGRPAAHMLTCLDATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGTNLG 242
Cdd:PRK14183  154 DVKGKDVCVVGASNIVGKPMAALLLNANATVDICHIFTKDLKAHTKKADIVIVGVGKPNLITEDMVKEGAIVIDIGINRT 233

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1786751629 243 PDGKMCGDADSAALAGTAGRITPVPGGVGPVTLACLLEAAVTAAERRA 290
Cdd:PRK14183  234 EDGRLVGDVDFENVAKKCSYITPVPGGVGPMTIAMLLSNTLKAAKNRA 281
PRK14171 PRK14171
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 1-285 1.22e-59

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172659 [Multi-domain]  Cd Length: 288  Bit Score: 191.71  E-value: 1.22e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   1 MADIIEGKTLSQSILADVAARAAAAAAALGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIETHLIMPEESKGRDHFFG 80
Cdd:PRK14171    1 MNNIIDGKALANEILADLKLEIQELKSQTNASPKLAIVLVGDNPASIIYVKNKIKNAHKIGIDTLLVNLSTTIHTNDLIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  81 LLRELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLFLAktwkeIAEGgfFVPCTALAVVKIMKHA 160
Cdd:PRK14171   81 KINELNLDNEISGIIVQLPLPSSIDKNKILSAVSPSKDIDGFHPLNVGYLHSG-----ISQG--FIPCTALGCLAVIKKY 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 161 GIDPAGKEIAVVGRSAIVGRPAAHMLTCLDATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGTN 240
Cdd:PRK14171  154 EPNLTGKNVVIIGRSNIVGKPLSALLLKENCSVTICHSKTHNLSSITSKADIVVAAIGSPLKLTAEYFNPESIVIDVGIN 233

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1786751629 241 LGPDGKMCGDADSAALAGTAGRITPVPGGVGPVTLACLLEAAVTA 285
Cdd:PRK14171  234 RISGNKIIGDVDFENVKSKVKYITPVPGGIGPMTIAFLLKNTVKA 278
PRK14177 PRK14177
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 4-279 3.92e-59

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172665 [Multi-domain]  Cd Length: 284  Bit Score: 190.18  E-value: 3.92e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   4 IIEGKTLSQSILADVAARAAAAAAALGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIETHLIMPEESKGRDHFFGLLR 83
Cdd:PRK14177    5 LLDGKKLSEKIRNEIRETIEERKTKNKRIPKLATILVGNNPASETYVSMKVKACHKVGMGSEMIRLKEQTTTEELLGVID 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  84 ELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLFLAKTwkeiaeggFFVPCTALAVVKIMKHAGID 163
Cdd:PRK14177   85 KLNLDPNVDGILLQHPVPSQIDERAAFDRIALEKDVDGVTTLSFGKLSMGVE--------TYLPCTPYGMVLLLKEYGID 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 164 PAGKEIAVVGRSAIVGRPAAHMLTCLDATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGTNLGP 243
Cdd:PRK14177  157 VTGKNAVVVGRSPILGKPMAMLLTEMNATVTLCHSKTQNLPSIVRQADIIVGAVGKPEFIKADWISEGAVLLDAGYNPGN 236

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1786751629 244 dgkmCGDADSAALAGTAGRITPVPGGVGPVTLACLL 279
Cdd:PRK14177  237 ----VGDIEISKAKDKSSFYTPVPGGVGPMTIAVLL 268
PRK14170 PRK14170
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 1-288 2.44e-58

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172658 [Multi-domain]  Cd Length: 284  Bit Score: 188.36  E-value: 2.44e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   1 MADIIEGKTLSQSILADVAARAAAAAAaLGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIETHLIMPEESKGRDHFFG 80
Cdd:PRK14170    1 MGEIIDGKKLAKEIQEKVTREVAELVK-EGKKPGLAVVLVGDNQASRTYVRNKQKRTEEAGMKSVLIELPENVTEEKLLS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  81 LLRELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLFLAKTwkeiaeggFFVPCTALAVVKIMKHA 160
Cdd:PRK14170   80 VVEELNEDKTIHGILVQLPLPEHISEEKVIDTISYDKDVDGFHPVNVGNLFIGKD--------SFVPCTPAGIIELIKST 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 161 GIDPAGKEIAVVGRSAIVGRPAAHMLTCLDATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGTN 240
Cdd:PRK14170  152 GTQIEGKRAVVIGRSNIVGKPVAQLLLNENATVTIAHSRTKDLPQVAKEADILVVATGLAKFVKKDYIKPGAIVIDVGMD 231

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1786751629 241 LGPDGKMCGDADSAALAGTAGRITPVPGGVGPVTLACLLEAAVTAAER 288
Cdd:PRK14170  232 RDENNKLCGDVDFDDVVEEAGFITPVPGGVGPMTITMLLANTLKAAKR 279
PRK14192 PRK14192
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 1-291 2.69e-58

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 184561 [Multi-domain]  Cd Length: 283  Bit Score: 188.13  E-value: 2.69e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   1 MADIIEGKTLSQSILADVAARAAAAAAALGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIETHLIMPEESKGRDHFFG 80
Cdd:PRK14192    2 MALVLDGKALAKQIEEELSVRVEALKAKTGRTPILATILVGDDPASATYVRMKGNACRRVGMDSLKVELPQETTTEQLLA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  81 LLRELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLFLaktwKEIAEGGffvpCTALAVVKIMKHA 160
Cdd:PRK14192   82 KIEELNANPDVHGILLQHPVPAQIDERACFDAISLAKDVDGVTCLGFGRMAM----GEAAYGS----ATPAGIMRLLKAY 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 161 GIDPAGKEIAVVGRSAIVGRPAAHMLTCLDATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGTN 240
Cdd:PRK14192  154 NIELAGKHAVVVGRSAILGKPMAMMLLNANATVTICHSRTQNLPELVKQADIIVGAVGKPELIKKDWIKQGAVVVDAGFH 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1786751629 241 LGPDGKmCGDADSAALAGTAGRITPVPGGVGPVTLACLLEAAVTAAERRAR 291
Cdd:PRK14192  234 PRDGGG-VGDIELQGIEEIASAYTPVPGGVGPMTINTLIRQTVEAAEKALG 283
PRK14167 PRK14167
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 1-286 5.28e-57

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 184549 [Multi-domain]  Cd Length: 297  Bit Score: 185.37  E-value: 5.28e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   1 MADIIEGKTLSQSILADVAARAAAAAAAlGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIET--HLIMPEESKgrDHF 78
Cdd:PRK14167    1 MTEIIDGNAVAAQIRDDLTDAIETLEDA-GVTPGLATVLMSDDPASETYVSMKQRDCEEVGIEAidVEIDPDAPA--EEL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  79 FGLLRELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLflaktwkeIAEGGFFVPCTALAVVKIMK 158
Cdd:PRK14167   78 YDTIDELNADEDVHGILVQMPVPDHVDDREVLRRIDPAKDVDGFHPENVGRL--------VAGDARFKPCTPHGIQKLLA 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 159 HAGIDPAGKEIAVVGRSAIVGRPAAHMLTCL----DATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATV 234
Cdd:PRK14167  150 AAGVDTEGADVVVVGRSDIVGKPMANLLIQKadggNATVTVCHSRTDDLAAKTRRADIVVAAAGVPELIDGSMLSEGATV 229

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1786751629 235 IDVGTNLGPDG-----KMCGDADSAALAGTAGRITPVPGGVGPVTLACLLEAAVTAA 286
Cdd:PRK14167  230 IDVGINRVDADtekgyELVGDVEFESAKEKASAITPVPGGVGPMTRAMLLYNTVKAA 286
PLN02516 PLN02516
methylenetetrahydrofolate dehydrogenase (NADP+)
 1-288 4.68e-56

methylenetetrahydrofolate dehydrogenase (NADP+)


Pssm-ID: 178131 [Multi-domain]  Cd Length: 299  Bit Score: 182.78  E-value: 4.68e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   1 MADIIEGKTLSQSILADVAARAAAAAAALGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIETHLIMPEESKGRDHFFG 80
Cdd:PLN02516    8 VAQIIDGKAIAKAIRSEIAEEVAQLSEKHGKVPGLAVVIVGSRKDSQTYVNMKRKACAEVGIKSFDVDLPENISEAELIS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  81 LLRELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLFLAktwkeiAEGGFFVPCTALAVVKIMKHA 160
Cdd:PLN02516   88 KVHELNANPDVHGILVQLPLPKHINEEKILNEISLEKDVDGFHPLNIGKLAMK------GREPLFLPCTPKGCLELLSRS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 161 GIDPAGKEIAVVGRSAIVGRPAAHMLTCLDATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGTN 240
Cdd:PLN02516  162 GIPIKGKKAVVVGRSNIVGLPVSLLLLKADATVTVVHSRTPDPESIVREADIVIAAAGQAMMIKGDWIKPGAAVIDVGTN 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1786751629 241 LGPDG------KMCGDADSAALAGTAGRITPVPGGVGPVTLACLLEAAVTAAER 288
Cdd:PLN02516  242 AVSDPskksgyRLVGDVDFAEVSKVAGWITPVPGGVGPMTVAMLLKNTVDGAKR 295
PRK14182 PRK14182
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 4-291 1.21e-55

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 172670 [Multi-domain]  Cd Length: 282  Bit Score: 181.37  E-value: 1.21e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   4 IIEGKTLSQSILADVAARAAAAAAAlGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIETHLIMPEESKGRDHFFGLLR 83
Cdd:PRK14182    3 LIDGKQIAAKVKGEVATEVRALAAR-GVQTGLTVVRVGDDPASAIYVRGKRKDCEEVGITSVEHHLPATTTQAELLALIA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  84 ELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLflaktwkEIAEGGFFVPCTALAVVKIMKHAGID 163
Cdd:PRK14182   82 RLNADPAVHGILVQLPLPKHVDERAVLDAISPAKDADGFHPFNVGAL-------SIGIAGVPRPCTPAGVMRMLDEARVD 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 164 PAGKEIAVVGRSAIVGRPAAHMLTCLDATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGTNLGP 243
Cdd:PRK14182  155 PKGKRALVVGRSNIVGKPMAMMLLERHATVTIAHSRTADLAGEVGRADILVAAIGKAELVKGAWVKEGAVVIDVGMNRLA 234

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1786751629 244 DGKMCGDADSAALAGTAGRITPVPGGVGPVTLACLLEAAVTAAERRAR 291
Cdd:PRK14182  235 DGKLVGDVEFAAAAARASAITPVPGGVGPMTRAMLLVNTVELAKRTAR 282
PRK14185 PRK14185
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 4-288 2.83e-54

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 184556 [Multi-domain]  Cd Length: 293  Bit Score: 178.10  E-value: 2.83e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   4 IIEGKTLSQSILADVAARAAAAAAALGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIETHLIMPEESKGRDHFFGLLR 83
Cdd:PRK14185    3 LIDGKAISAQIKQEIAAEVAEIVAKGGKRPHLAAILVGHDGGSETYVANKVKACEECGFKSSLIRYESDVTEEELLAKVR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  84 ELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLFLAKTWkeiaeggfFVPCTALAVVKIMKHAGID 163
Cdd:PRK14185   83 ELNQDDDVDGFIVQLPLPKHISEQKVIEAIDYRKDVDGFHPINVGRMSIGLPC--------FVSATPNGILELLKRYHIE 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 164 PAGKEIAVVGRSAIVGRPAAHMLT----CLDATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGT 239
Cdd:PRK14185  155 TSGKKCVVLGRSNIVGKPMAQLMMqkayPGDCTVTVCHSRSKNLKKECLEADIIIAALGQPEFVKADMVKEGAVVIDVGT 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1786751629 240 NLGPDG------KMCGDADSAALAGTAGRITPVPGGVGPVTLACLLEAAVTAAER 288
Cdd:PRK14185  235 TRVPDAtrksgfKLTGDVKFDEVAPKCSYITPVPGGVGPMTIVSLMKNTLLAGKK 289
PLN02616 PLN02616
tetrahydrofolate dehydrogenase/cyclohydrolase, putative
 2-288 2.70e-53

tetrahydrofolate dehydrogenase/cyclohydrolase, putative


Pssm-ID: 215332 [Multi-domain]  Cd Length: 364  Bit Score: 177.89  E-value: 2.70e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   2 ADIIEGKTLSQSILADVAARAAAAAAALGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIETHLIMPEESKGRDHFFGL 81
Cdd:PLN02616   73 AKVIDGKAVAKKIRDEITIEVSRMKESIGVVPGLAVILVGDRKDSATYVRNKKKACDSVGINSFEVRLPEDSTEQEVLKF 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  82 LRELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLFLAktwkeiAEGGFFVPCTALAVVKIMKHAG 161
Cdd:PLN02616  153 ISGFNNDPSVHGILVQLPLPSHMDEQNILNAVSIEKDVDGFHPLNIGRLAMR------GREPLFVPCTPKGCIELLHRYN 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 162 IDPAGKEIAVVGRSAIVGRPAAHMLTCLDATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGTNL 241
Cdd:PLN02616  227 VEIKGKRAVVIGRSNIVGMPAALLLQREDATVSIVHSRTKNPEEITREADIIISAVGQPNMVRGSWIKPGAVVIDVGINP 306

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1786751629 242 GPDG------KMCGDADSAALAGTAGRITPVPGGVGPVTLACLLEAAVTAAER 288
Cdd:PLN02616  307 VEDAssprgyRLVGDVCYEEACKVASAVTPVPGGVGPMTIAMLLSNTLTSAKR 359
PLN02897 PLN02897
tetrahydrofolate dehydrogenase/cyclohydrolase, putative
 2-288 1.38e-51

tetrahydrofolate dehydrogenase/cyclohydrolase, putative


Pssm-ID: 178485 [Multi-domain]  Cd Length: 345  Bit Score: 172.84  E-value: 1.38e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   2 ADIIEGKTLSQSILADVAARAAAAAAALGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIETHLIMPEESKGRDHFFGL 81
Cdd:PLN02897   56 TVVIDGNVIAEEIRTKIASEVRKMKKAVGKVPGLAVVLVGQQRDSQTYVRNKIKACEETGIKSLLAELPEDCTEGQILSA 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  82 LRELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLflAKTWKEiaegGFFVPCTALAVVKIMKHAG 161
Cdd:PLN02897  136 LRKFNEDTSIHGILVQLPLPQHLDESKILNMVRLEKDVDGFHPLNVGNL--AMRGRE----PLFVSCTPKGCVELLIRSG 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 162 IDPAGKEIAVVGRSAIVGRPAAHMLTCLDATVTLCHSRTRDINAVLKRAEIIVTAIG-----KALWLKPdmigpGATVID 236
Cdd:PLN02897  210 VEIAGKNAVVIGRSNIVGLPMSLLLQRHDATVSTVHAFTKDPEQITRKADIVIAAAGipnlvRGSWLKP-----GAVVID 284

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1786751629 237 VGTNLGPDG------KMCGDADSAALAGTAGRITPVPGGVGPVTLACLLEAAVTAAER 288
Cdd:PLN02897  285 VGTTPVEDSscefgyRLVGDVCYEEALGVASAITPVPGGVGPMTITMLLCNTLDAAKR 342
PRK14168 PRK14168
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 2-286 1.67e-49

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 237633 [Multi-domain]  Cd Length: 297  Bit Score: 165.82  E-value: 1.67e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   2 ADIIEGKTLSQSILADVAARAAAAAAALGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGI-ETHLIMPEESKGRDhFFG 80
Cdd:PRK14168    3 AKIIKGTEIREEILEEIRGEVAELKEKYGKVPGLVTILVGESPASLSYVTLKIKTAHRLGFhEIQDNQSVDITEEE-LLA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  81 LLRELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLFLAKTwkEIAeggfFVPCTALAVVKIMKHA 160
Cdd:PRK14168   82 LIDKYNNDDSIHGILVQLPLPKHINEKKVLNAIDPDKDVDGFHPVNVGRLMIGGD--EVK----FLPCTPAGIQEMLVRS 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 161 GIDPAGKEIAVVGRSAIVGRPAAHMLT----CLDATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVID 236
Cdd:PRK14168  156 GVETSGAEVVVVGRSNIVGKPIANMMTqkgpGANATVTIVHTRSKNLARHCQRADILIVAAGVPNLVKPEWIKPGATVID 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1786751629 237 VGTN---LGPDGK---MCGDADSAALAGTAGRITPVPGGVGPVTLACLLEAAVTAA 286
Cdd:PRK14168  236 VGVNrvgTNESTGkaiLSGDVDFDAVKEIAGKITPVPGGVGPMTIAMLMRNTLKSA 291
PRK14187 PRK14187
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 1-286 3.68e-48

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172675 [Multi-domain]  Cd Length: 294  Bit Score: 162.30  E-value: 3.68e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   1 MADIIEGKTLSQSILADVAARAAAAAAALGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIETHLIMPEESKGRDHFFG 80
Cdd:PRK14187    1 ETNIIDGKKIANDITEILATCIDDLKRQHNLFPCLIVILVGDDPASQLYVRNKQRKAEMLGLRSETILLPSTISESSLIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  81 LLRELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLFLAKtwkeiaEGGFFVPCTALAVVKIMKHA 160
Cdd:PRK14187   81 KINELNNDDSVHGILVQLPVPNHIDKNLIINTIDPEKDVDGFHNENVGRLFTGQ------KKNCLIPCTPKGCLYLIKTI 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 161 GIDPAGKEIAVVGRSAIVGRPAAHMLTCLDATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGTN 240
Cdd:PRK14187  155 TRNLSGSDAVVIGRSNIVGKPMACLLLGENCTVTTVHSATRDLADYCSKADILVAAVGIPNFVKYSWIKKGAIVIDVGIN 234

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1786751629 241 ---LGPDGKMCGDADSAALAGTAGRITPVPGGVGPVTLACLLEAAVTAA 286
Cdd:PRK14187  235 sieEGGVKKFVGDVDFAEVKKKASAITPVPGGVGPMTIAFLMVNTVIAA 283
PRK14194 PRK14194
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 2-290 7.78e-48

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172682 [Multi-domain]  Cd Length: 301  Bit Score: 161.55  E-value: 7.78e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   2 ADIIEGKTLSQSILADVAARAAAAAAAlGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIET--HLIMPEESKGRdhFF 79
Cdd:PRK14194    4 AKLIDGKAAAARVLAQVREDVRTLKAA-GIEPALAVILVGNDPASQVYVRNKILRAEEAGIRSleHRLPADTSQAR--LL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  80 GLLRELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLFLAKTwkeiaeggFFVPCTALAVVKIMKH 159
Cdd:PRK14194   81 ALIAELNADPSVNGILLQLPLPAHIDEARVLQAINPLKDVDGFHSENVGGLSQGRD--------VLTPCTPSGCLRLLED 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 160 AGIDPAGKEIAVVGRSAIVGRPAAHMLTCLDATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGT 239
Cdd:PRK14194  153 TCGDLTGKHAVVIGRSNIVGKPMAALLLQAHCSVTVVHSRSTDAKALCRQADIVVAAVGRPRLIDADWLKPGAVVIDVGI 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1786751629 240 NLGPDG---KMCGDADSAALAGTAGRITPVPGGVGPVTLACLLEAAVTAAERRA 290
Cdd:PRK14194  233 NRIDDDgrsRLVGDVDFDSALPVVSAITPVPGGVGPMTIAFLMKNTVTAARLQA 286
PRK14180 PRK14180
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 4-291 3.60e-47

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 172668 [Multi-domain]  Cd Length: 282  Bit Score: 159.43  E-value: 3.60e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   4 IIEGKTLSQSILADVAARAAAAAAALGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIETHLIMPEESKGRDHFFGLLR 83
Cdd:PRK14180    3 LIDGKSLSKDLKERLATQVQEYKHHTAITPKLVAIIVGNDPASKTYVASKEKACAQVGIDSQVITLPEHTTESELLELID 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  84 ELGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPDALSTLNMGRLFLAKtwKEIAEGgffvpCTALAVVKIMKHAGID 163
Cdd:PRK14180   83 QLNNDSSVHAILVQLPLPAHINKNNVIYSIKPEKDVDGFHPTNVGRLQLRD--KKCLES-----CTPKGIMTMLREYGIK 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 164 PAGKEIAVVGRSAIVGRPAAHMLTCLDATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGTNlGP 243
Cdd:PRK14180  156 TEGAYAVVVGASNVVGKPVSQLLLNAKATVTTCHRFTTDLKSHTTKADILIVAVGKPNFITADMVKEGAVVIDVGIN-HV 234

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1786751629 244 DGKMCGDADSAALAGTAGRITPVPGGVGPVTLACLLEAAVTAAERRAR 291
Cdd:PRK14180  235 DGKIVGDVDFAAVKDKVAAITPVPGGVGPMTITELLYNTFQCAQELNR 282
PRK14181 PRK14181
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 33-279 1.31e-44

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172669 [Multi-domain]  Cd Length: 287  Bit Score: 153.09  E-value: 1.31e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629  33 PSLAIINYYEDSPSAVYVKRKLSACAKAGI--ETHLiMPEESKGRDhFFGLLRELGADNAVDAIMVERPLPKGFDAPEAW 110
Cdd:PRK14181   27 PGLAVVLIGNDPASEVYVGMKVKKATDLGMvsKAHR-LPSDATLSD-ILKLIHRLNNDPNIHGILVQLPLPKHLDAQAIL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 111 ELLDPAKDPDALSTLNMGRLFLAKTwkeiaegGFFVPCTALAVVKIMKHAGIDPAGKEIAVVGRSAIVGRPAAHML---- 186
Cdd:PRK14181  105 QAISPDKDVDGLHPVNMGKLLLGET-------DGFIPCTPAGIIELLKYYEIPLHGRHVAIVGRSNIVGKPLAALLmqkh 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 187 TCLDATVTLCHSRTRDINAVLKRAEIIVTAIGKALWLKPDMIGPGATVIDVGTNLGPDGK-----MCGDADSAALAGTAG 261
Cdd:PRK14181  178 PDTNATVTLLHSQSENLTEILKTADIIIAAIGVPLFIKEEMIAEKAVIVDVGTSRVPAANpkgyiLVGDVDFNNVVPKCR 257

                         250
                  ....*....|....*...
gi 1786751629 262 RITPVPGGVGPVTLACLL 279
Cdd:PRK14181  258 AITPVPGGVGPMTVAMLM 275
THF_DHG_CYH pfam00763
Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain;
5-120 1.71e-24

Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain;


Pssm-ID: 459930 [Multi-domain]  Cd Length: 115  Bit Score: 95.16  E-value: 1.71e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629   5 IEGKTLSQSILADVAARAAAAAAAlGRKPSLAIINYYEDSPSAVYVKRKLSACAKAGIETHLIMPEESKGRDHFFGLLRE 84
Cdd:pfam00763   1 IDGKAIAKKIREELKEEVAALKAG-GRKPGLAVILVGDDPASQVYVRNKKKACEEVGIESELIRLPEDTTEEELLALIDK 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1786751629  85 LGADNAVDAIMVERPLPKGFDAPEAWELLDPAKDPD 120
Cdd:pfam00763  80 LNADPSVHGILVQLPLPKHIDEEKVLEAIDPEKDVD 115
NAD_bind_m-THF_DH_Cyclohyd_like cd05212
NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and ...
 147-287 2.75e-19

NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NAD(P) binding domains of methylene-tetrahydrofolate dehydrogenase (m-THF DH) and m-THF DH/cyclohydrolase bifunctional enzymes (m-THF DH/cyclohydrolase). M-THF is a versatile carrier of activated one-carbon units. The major one-carbon folate donors are N-5 methyltetrahydrofolate, N5,N10-m-THF, and N10-formayltetrahydrofolate. The oxidation of metabolic intermediate m-THF to m-THF requires the enzyme m-THF DH. In addition, most DHs also have an associated cyclohydrolase activity which catalyzes its hydrolysis to N10-formyltetrahydrofolate. m-THF DH is typically found as part of a multifunctional protein in eukaryotes. NADP-dependent m-THF DH in mammals, birds and yeast are components of a trifunctional enzyme with DH, cyclohydrolase, and synthetase activities. Certain eukaryotic cells also contain homodimeric bifunctional DH/cyclodrolase form. In bacteria, mono-functional DH, as well as bifunctional DH/cyclodrolase are found. In addition, yeast (S. cerevisiae) also express a monofunctional DH. M-THF DH, like other amino acid DH-like NAD(P)-binding domains, is a member of the Rossmann fold superfamily which includes glutamate, leucine, and phenylalanine DHs, m-THF DH, methylene-tetrahydromethanopterin DH, m-THF DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.


Pssm-ID: 133451  Cd Length: 140  Bit Score: 82.17  E-value: 2.75e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 147 PCTALAVVKIMK-------HAGIDPAGKEIAVVGRSAIVGRPAAHMLTCLDATVTLCHSRTRDINAVLKRAEIIVTAIGK 219
Cdd:cd05212     2 PCTPLFVSPVAKavkellnKEGVRLDGKKVLVVGRSGIVGAPLQCLLQRDGATVYSCDWKTIQLQSKVHDADVVVVGSPK 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1786751629 220 ALWLKPDMIGPGATVIDVGTNLGPDGKMCGDADSaalagtagrITPVPGGVGPVTLACLLEAAVTAAE 287
Cdd:cd05212    82 PEKVPTEWIKPGATVINCSPTKLSGDDVKESASL---------YVPMTGGVGKLTVAMRMQNMVRSVR 140
NAD_bind_m-THF_DH cd01079
NAD binding domain of methylene-tetrahydrofolate dehydrogenase; The NAD-binding domain of ...
 115-279 1.70e-08

NAD binding domain of methylene-tetrahydrofolate dehydrogenase; The NAD-binding domain of methylene-tetrahydrofolate dehydrogenase (m-THF DH). M-THF is a versatile carrier of activated one-carbon units. The major one-carbon folate donors are N-5 methyltetrahydrofolate, N5,N10-m-THF, and N10-formayltetrahydrofolate. The oxidation of metabolic intermediate m-THF to m-THF requires the enzyme m-THF DH. M-THF DH is a component of an unusual monofunctional enzyme; in eukaryotes, m-THF DH is typically found as part of a multifunctional protein. NADP-dependent m-THF DHs in mammals, birds and yeast are components of a trifunctional enzyme with DH, cyclohydrolase, and synthetase activities. Certain eukaryotic cells also contain homodimeric bifunctional DH/cyclodrolase form. In bacteria, monofunctional DH, as well as bifunctional DH/cyclodrolase are found. In addition, yeast (S. cerevisiae) also express an monofunctional DH. This family contains only the monofunctional DHs from S. cerevisiae and certain bacteria. M-THF DH, like other amino acid DH-like NAD(P)-binding domains, is a member of the Rossmann fold superfamily which includes glutamate, leucine, and phenylalanine DHs, m-THF DH, methylene-tetrahydromethanopterin DH, m-THF DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.


Pssm-ID: 133447 [Multi-domain]  Cd Length: 197  Bit Score: 53.58  E-value: 1.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 115 PAKDPDALSTLNMGRL-----FL--AKTWKEIaeggffVPCTALAVVKIMKHAGI--------DPA-GKEIAVVGRSAIV 178
Cdd:cd01079     1 PHKDVEGLSHKYIFNLyhnirFLdpENRKKSI------LPCTPLAIVKILEFLGIynkilpygNRLyGKTITIINRSEVV 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1786751629 179 GRPAAHMLTCLDATV---------------------TLCHSRTRDINAVLKRAEIIVTAIGKALW-LKPDMIGPGATVID 236
Cdd:cd01079    75 GRPLAALLANDGARVysvdingiqvftrgesirhekHHVTDEEAMTLDCLSQSDVVITGVPSPNYkVPTELLKDGAICIN 154

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1786751629 237 VGtnlgpdgkmCGDADSAALAGTAGRITPVpggVGPVTLACLL 279
Cdd:cd01079   155 FA---------SIKNFEPSVKEKASIYVPS---IGKVTIAMLL 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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