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Conserved domains on  [gi|1802320089|gb|KAF1215106|]
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ferrichrome ABC transporter permease [Streptococcus agalactiae]

Protein Classification

FecCD family ABC transporter permease( domain architecture ID 10001816)

FecCD family ABC transporter permease such as iron ABC transporter permease, which is the transmembrane subunit (TM) found in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter involved in the import of iron and iron-containing compounds

CATH:  1.10.3470.10
Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
SCOP:  4002900
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 29-331 3.61e-86

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 440374  Cd Length: 306  Bit Score: 261.54  E-value: 3.61e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089  29 GYANTSVIDVLKLISGKSDDAFL-FIITNIRLPRIIVCIFGGASLGIAGLLLQTLTKNPLADSGILGINAGAGLVIALTI 107
Cdd:COG0609     5 GAVPISLSDVLRALLGPDGDPTAdLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAVLAI 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 108 GTFNVSNPtilYFLPLFAMFGGLVTIFLVYLMSyRRNHNISPTRLIVTGIGISTMISGVMISIISQSNNQKMDMIVEWLS 187
Cdd:COG0609    85 VLGGGLSA---LGLPLAAFLGALLAALLVYLLA-RRGGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEQLRSIVFWLM 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 188 GKITISSWTTIITFIPILILLWGLAYSRSRHLNIMNLNEQTALALGLHLKKERIYTLMLASSLAAISVVLIGNITFIGLL 267
Cdd:COG0609   161 GSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLV 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1802320089 268 AGHLSRRLLGNNHKIILPSCLLIGAIILLVSDTIGRILLVGTGIPTGLVVSIIGAPYFLWLMTK 331
Cdd:COG0609   241 VPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRR 304
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 29-331 3.61e-86

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 261.54  E-value: 3.61e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089  29 GYANTSVIDVLKLISGKSDDAFL-FIITNIRLPRIIVCIFGGASLGIAGLLLQTLTKNPLADSGILGINAGAGLVIALTI 107
Cdd:COG0609     5 GAVPISLSDVLRALLGPDGDPTAdLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAVLAI 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 108 GTFNVSNPtilYFLPLFAMFGGLVTIFLVYLMSyRRNHNISPTRLIVTGIGISTMISGVMISIISQSNNQKMDMIVEWLS 187
Cdd:COG0609    85 VLGGGLSA---LGLPLAAFLGALLAALLVYLLA-RRGGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEQLRSIVFWLM 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 188 GKITISSWTTIITFIPILILLWGLAYSRSRHLNIMNLNEQTALALGLHLKKERIYTLMLASSLAAISVVLIGNITFIGLL 267
Cdd:COG0609   161 GSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLV 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1802320089 268 AGHLSRRLLGNNHKIILPSCLLIGAIILLVSDTIGRILLVGTGIPTGLVVSIIGAPYFLWLMTK 331
Cdd:COG0609   241 VPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRR 304
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 29-331 1.80e-73

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 229.34  E-value: 1.80e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089  29 GYANTSVIDVLKLISGKSDDAFLFIITNIRLPRIIVCIFGGASLGIAGLLLQTLTKNPLADSGILGINAGAGLVIALTIG 108
Cdd:pfam01032  13 GAVKISPSDVFSALLGGDDSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISSGAALGAVLAIL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 109 TFNVSNPtilYFLPLFAMFGGLVTIFLVYLMSYRRNHnISPTRLIVTGIGISTMISGVMISIISQSNNQKMDMIVEWLSG 188
Cdd:pfam01032  93 LGGSLSL---FALPLAAFIGALLAALLVYFLSRGRGG-ASPLRLILAGIAVSALLSALTSLLLLLLNPEALQSILFWLMG 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 189 KITISSWTTIITFIPILILLWGLAYSRSRHLNIMNLNEQTALALGLHLKKERIYTLMLASSLAAISVVLIGNITFIGLLA 268
Cdd:pfam01032 169 SLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGPIGFVGLIV 248

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1802320089 269 GHLSRRLLGNNHKIILPSCLLIGAIILLVSDTIGRILLVGTGIPTGLVVSIIGAPYFLWLMTK 331
Cdd:pfam01032 249 PHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
58-331 5.53e-64

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 214.32  E-value: 5.53e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089  58 RLPRIIVCIFGGASLGIAGLLLQTLTKNPLADSGILGINAGAGLVIALTIGTFNVSNPTilyFLPLFAMFGGLVTIFLVY 137
Cdd:PRK10577  397 RLPRLLAALLAGAMLAVAGTLLQRLTRNPLASPEVLGISSGAGLGVVLALFLVPGAGFG---WLLAAALLGALAALALIL 473

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 138 LMSYRrnHNISPTRLIVTGIGISTMISGVmISIISQSNNQKMDMIVEWLSGKITISSWTTIITFIPILILLWGLAYSRSR 217
Cdd:PRK10577  474 LLARR--GGFAPERLLLTGIALSALFTAL-IQLLLASGDPRAAQLLTWLSGSTYGVTWAQALPLLIVAVLLLALALLLRR 550

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 218 HLNIMNLNEQTALALGLHLKKERIYTLMLASSLAAISVVLIGNITFIGLLAGHLSRRLLGNNHKIILPSCLLIGAIILLV 297
Cdd:PRK10577  551 WLDLLPLGDDTARALGLPVTRARLALLLLAALLTAAATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALLMVL 630

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1802320089 298 SDTIGRILLVGTGIPTGLVVSIIGAPYFLWLMTK 331
Cdd:PRK10577  631 ADWLGRTLLFPYQIPAGLLAALIGAPYFLWLLRR 664
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 62-329 1.92e-41

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 145.01  E-value: 1.92e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089  62 IIVCIFGGASLGIAGLLLQTLTKNPLADSGILGINAGAGLVIALTIGTFNVSNPtilYFLPLFAMFGGLVTIFLVYLMSY 141
Cdd:cd06550     1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSN---YALGAFAFAGALAIALLVLLLAS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 142 RRNHNISptRLIVTGIGISTMISGVMISIISQSNNQKMDMIVeWLSGKITISSWTTIITFIPILILLWGLAYSRSRHLNI 221
Cdd:cd06550    78 RGGLSPS--KLILIGIVLSAFFSAGVILISLLSDDSLQDLNI-WLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 222 MNLNEQTALALGLHLKKERIYTLMLASSLAAISVVLIGNITFIGLLAGHLSRRLLGNNHKIILPSCLLIGAIILLVSDTI 301
Cdd:cd06550   155 LTFDEDLAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLL 234

                         250       260
                  ....*....|....*....|....*...
gi 1802320089 302 GRILLVGtGIPTGLVVSIIGAPYFLWLM 329
Cdd:cd06550   235 SRTLLPS-ELPVGPVTALLGAPYFLYLL 261
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 29-331 3.61e-86

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 261.54  E-value: 3.61e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089  29 GYANTSVIDVLKLISGKSDDAFL-FIITNIRLPRIIVCIFGGASLGIAGLLLQTLTKNPLADSGILGINAGAGLVIALTI 107
Cdd:COG0609     5 GAVPISLSDVLRALLGPDGDPTAdLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAVLAI 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 108 GTFNVSNPtilYFLPLFAMFGGLVTIFLVYLMSyRRNHNISPTRLIVTGIGISTMISGVMISIISQSNNQKMDMIVEWLS 187
Cdd:COG0609    85 VLGGGLSA---LGLPLAAFLGALLAALLVYLLA-RRGGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEQLRSIVFWLM 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 188 GKITISSWTTIITFIPILILLWGLAYSRSRHLNIMNLNEQTALALGLHLKKERIYTLMLASSLAAISVVLIGNITFIGLL 267
Cdd:COG0609   161 GSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLV 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1802320089 268 AGHLSRRLLGNNHKIILPSCLLIGAIILLVSDTIGRILLVGTGIPTGLVVSIIGAPYFLWLMTK 331
Cdd:COG0609   241 VPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRR 304
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 29-331 1.80e-73

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 229.34  E-value: 1.80e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089  29 GYANTSVIDVLKLISGKSDDAFLFIITNIRLPRIIVCIFGGASLGIAGLLLQTLTKNPLADSGILGINAGAGLVIALTIG 108
Cdd:pfam01032  13 GAVKISPSDVFSALLGGDDSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISSGAALGAVLAIL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 109 TFNVSNPtilYFLPLFAMFGGLVTIFLVYLMSYRRNHnISPTRLIVTGIGISTMISGVMISIISQSNNQKMDMIVEWLSG 188
Cdd:pfam01032  93 LGGSLSL---FALPLAAFIGALLAALLVYFLSRGRGG-ASPLRLILAGIAVSALLSALTSLLLLLLNPEALQSILFWLMG 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 189 KITISSWTTIITFIPILILLWGLAYSRSRHLNIMNLNEQTALALGLHLKKERIYTLMLASSLAAISVVLIGNITFIGLLA 268
Cdd:pfam01032 169 SLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGPIGFVGLIV 248

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1802320089 269 GHLSRRLLGNNHKIILPSCLLIGAIILLVSDTIGRILLVGTGIPTGLVVSIIGAPYFLWLMTK 331
Cdd:pfam01032 249 PHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
58-331 5.53e-64

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 214.32  E-value: 5.53e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089  58 RLPRIIVCIFGGASLGIAGLLLQTLTKNPLADSGILGINAGAGLVIALTIGTFNVSNPTilyFLPLFAMFGGLVTIFLVY 137
Cdd:PRK10577  397 RLPRLLAALLAGAMLAVAGTLLQRLTRNPLASPEVLGISSGAGLGVVLALFLVPGAGFG---WLLAAALLGALAALALIL 473

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 138 LMSYRrnHNISPTRLIVTGIGISTMISGVmISIISQSNNQKMDMIVEWLSGKITISSWTTIITFIPILILLWGLAYSRSR 217
Cdd:PRK10577  474 LLARR--GGFAPERLLLTGIALSALFTAL-IQLLLASGDPRAAQLLTWLSGSTYGVTWAQALPLLIVAVLLLALALLLRR 550

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 218 HLNIMNLNEQTALALGLHLKKERIYTLMLASSLAAISVVLIGNITFIGLLAGHLSRRLLGNNHKIILPSCLLIGAIILLV 297
Cdd:PRK10577  551 WLDLLPLGDDTARALGLPVTRARLALLLLAALLTAAATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALLMVL 630

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1802320089 298 SDTIGRILLVGTGIPTGLVVSIIGAPYFLWLMTK 331
Cdd:PRK10577  631 ADWLGRTLLFPYQIPAGLLAALIGAPYFLWLLRR 664
FepG COG4779
ABC-type enterobactin transport system, permease component [Inorganic ion transport and ...
 29-329 4.49e-61

ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443810  Cd Length: 344  Bit Score: 198.42  E-value: 4.49e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089  29 GYANTSVIDVLKLISGKSDDAFLFIITNIRLPRIIVCIFGGASLGIAGLLLQTLTKNPLADSGILGINAGAGLVIALTIG 108
Cdd:COG4779    44 GDYPLSPGDVLRALLGEGDPGASFVVLELRLPRALAALLVGAALGLSGAIFQSLTRNPLASPDIIGITAGASAGAVAAIV 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 109 TFNVSNPTIlyflPLFAMFGGLVTIFLVYLMSYRRnhNISPTRLIVTGIGISTMISGV---MISIISQsnNQKMDMIVeW 185
Cdd:COG4779   124 VLGGSGLAV----ALGALAGGLATALLVYLLAWRG--GVSGYRLILVGIGVSAMLTAVnsyLLTRADL--EDAQSAAV-W 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 186 LSGKITISSWTTIITFIPILILLWGLAYSRSRHLNIMNLNEQTALALGLHLKKERIYTLMLASSLAAISVVLIGNITFIG 265
Cdd:COG4779   195 LTGSLNGRTWEDVLPLAVALAVLLPLALALARRLRLLELGDDTAAALGVRVERTRLLLLLVAVALAAVATAAAGPIAFVA 274

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1802320089 266 LLAGHLSRRLLGNNHKIILPSClLIGAIILLVSDTIGRILLVGTGIPTGLVVSIIGAPYFLWLM 329
Cdd:COG4779   275 LAAPQIARRLTRSPGPPLLPSA-LVGALLLLAADLVAQHLLAPVQLPVGVVTGALGGPYLLWLL 337
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
46-331 1.11e-50

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 171.00  E-value: 1.11e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089  46 SDDAFLFIITNIRLPRIIVCIFGGASLGIAGLLLQTLTKNPLADSGILGINAGAGLVialTIGTFNVSNPTILYFLPLFA 125
Cdd:PRK09777   39 AGDEHYYVLMEYRLPRLLLALFVGAALAVSGVLVQGIVRNPLASPDILGVNHAASLA---SVGALLLFPSLPVMWLPLLA 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 126 MFGGLVTIFLVYLMSYRRnhniSPTRLIVTGIGISTMISGVmISIISQSNNQKMDMIVEWLSGKITISSWTTIITFIPIL 205
Cdd:PRK09777  116 FIGGMAGLILLKMLAGTH----QPMKLALTGVALSALWASL-TDYLMLSRPQDINNALLWLTGSLWGRDWSFVKVALPWL 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 206 ILLWGLAYSRSRHLNIMNLNEQTALALGLHLKKERIYTLMLASSLAAISVVLIGNITFIGLLAGHLSRRLLGNNHKIILP 285
Cdd:PRK09777  191 ILLLPLSLSFCRDLDLLALGDARATTLGVSVPHTQFWALLLAVALTATGVAACGPISFIGLVVPHLMRSLVGGRHRRLLP 270

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1802320089 286 SCLLIGAIILLVSDTIGRILLVGTGIPTGLVVSIIGAPYFLWLMTK 331
Cdd:PRK09777  271 VSALTGALLLLLADLLARIIHPPLELPAGVLTAIIGAPWFFWLLVR 316
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
41-328 4.18e-46

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 159.09  E-value: 4.18e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089  41 LISGKSDDAFLFIITNIRLPRIIVCIFGGASLGIAGLLLQTLTKNPLADSGILGINAGAGLVIALTIGTfnVSNPTILYF 120
Cdd:PRK11228   34 LLPGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGALLQTLTHNPLASPSLLGINSGAALAMALTSAL--SPTPFAGYS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 121 LPLFAMFGGLVTIFLVYLMSYRRNHNISPTRLIVTGIGISTMISGV--MISIISQSNNQKmdmIVEWLSGKITISSWTTI 198
Cdd:PRK11228  112 LAFIAACGGGLSWLLVMTAGGGWRHTHDRNRLILAGIALSALCMALtrITLLLAEDHAYG---IFYWLAGGVSHARWQEV 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 199 ITFIPILILLWGLAYSRSRHLNIMNLNEQTALALGLHLKKERIYTLMLASSLAAISVVLIGNITFIGLLAGHLSRRLLGN 278
Cdd:PRK11228  189 WQLLPFVVTAVPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLLVGACVSVAGPVAFIGLLVPHLARFWIGY 268

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1802320089 279 NHKIILPSCLLIGAIILLVSDTIGRILLVGTGIPTGLVVSIIGAPYFLWL 328
Cdd:PRK11228  269 DQRNVLPMSMLLGATLMLLADLLARALAFPGELPAGAVLALIGAPCFVWL 318
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
29-329 7.15e-46

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 165.01  E-value: 7.15e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089  29 GYANTSVIDVLKLISGKSDDAF-LFIITNIRLPRIIVCIFGGASLGIAGLLLQTLTKNPLADSGILGINAGAGLVIALTI 107
Cdd:PRK10577   32 LSAALPLSQWLQALWGPDADDLeQLLLHYSRLPRLAIALLVGAALGLAGALLQQVLRNPLASPTTLGVAAGAQLALVLAT 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 108 GTFnvsnPTILYFLP-LFAMFGGLVTIFLVYLMSYRRNhnISPTRLIVTGIGIStMISGVMISIISQSNNQKMDMIVEWL 186
Cdd:PRK10577  112 LFA----PALLALASqLAAFAGGLLAAALVFALAGGKR--LSPLRLVLAGMVVS-LYLGALTTLLLLFNEQYLQGLFLWG 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 187 SGKITISSWTTIITFIPILILLWGLAYSRSRHLNIMNLNEQTALALGLHLKKERIYTLMLASSLAAISVVLIGNITFIGL 266
Cdd:PRK10577  185 AGSLAQNDWSGVQRLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRLAALALAVLLSAAVVSAVGPIGFIGL 264

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1802320089 267 LAGHLSRRLLGNNHKIILPSCLLIGAIILLVSDTIGRIL--LVGTGIPTGLVVSIIGAPYFLWLM 329
Cdd:PRK10577  265 AAPNLARLLGARRLRARLPLSPLIGALLLLLTDQLVRLLagVGGELLPTGAVTALIGAPLLLWLL 329
BtuC COG4139
ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and ...
 47-331 5.43e-45

ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and metabolism];


Pssm-ID: 443314  Cd Length: 327  Bit Score: 156.17  E-value: 5.43e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089  47 DDAFLFIITNIRLPRIIVCIFGGASLGIAGLLLQTLTKNPLADSGILGINAGAGLVIALTIGTFNVSNPtiLYFLPLFAM 126
Cdd:COG4139    44 SEAWQLFVWQLRLPRTLAAVLVGASLAVSGAVMQALFENPLAEPGLLGISNGAGVGLVLVVLLGGGLLP--PWLLSLAAI 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 127 FGGLVTIFLVYLMSYRRnhnISPTRLIVTGIGISTMISGVMISIISQSNNQKMDMIVEWLSGK---ITISSWTTIITFIP 203
Cdd:COG4139   122 AGALLVTLLLLAFARRR---LSNARLLLIGVALGIICSAIMTWAVYFSSSLDLRQLMYWMMGSfggVDWRQLWLLLALLP 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 204 ILILLwglaYSRSRHLNIMNLNEQTALALGLHLKKERiYTLMLASS-LAAISVVLIGNITFIGLLAGHLSRRLLGNNHKI 282
Cdd:COG4139   199 VLLWL----CLQGKPLNLLLLGENQARQLGLSVHRWR-NLLVLATGlLVGVSVALAGPIGFVGLVVPHLLRLLGTTDHRF 273

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1802320089 283 ILPSCLLIGAIILLVSDTIGRILLVGTGIPTGLVVSIIGAPYFLWLMTK 331
Cdd:COG4139   274 LLPACALAGAALLLLADIIARLALSSAELPIGVVTATLGAPVFIWLLLR 322
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
38-328 9.37e-45

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 156.02  E-value: 9.37e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089  38 VLKLISGKSDDAFLFIITNIRLPRIIVCIFGGASLGIAGLLLQTLTKNPLADSGILGINAGAGLVIALTIGTFNVSNPTI 117
Cdd:PRK10441   40 VLEALSGTCQSADCTIVLDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLLGVNAGASFAIVLGAALFGYSSAQE 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 118 LYflpLFAMFGGLVTIFLVYLMSYRRNHNISPTRLIVTGIGISTMISGvMISIISQSNNQKMDMIVEWLSGKITISSWTT 197
Cdd:PRK10441  120 QL---AMAFAGALVASLIVAFTGSQGGGQLSPVRLTLAGVALAAVLEG-LTSGIALLNPDVYDQLRFWQAGSLDIRNLHT 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 198 IITFIPILILLWGLAYSRSRHLNIMNLNEQTALALGLHLKKERIYTLMLASSLAAISVVLIGNITFIGLLAGHLSRRLLG 277
Cdd:PRK10441  196 LKVVLIPVLIAGATALLLSRALNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSATAVVGPIAFIGLMMPHMARWLVG 275

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1802320089 278 NNHKIILPSCLLIGAIILLVSDTIGRILLVGTgIPTGLVVSIIGAPYFLWL 328
Cdd:PRK10441  276 ADHRWSLPVTLLATPALLLFADIIGRLLVPGE-LRVSVVSAFIGAPVLIFL 325
btuC PRK09535
cobalamin ABC transporter permease BtuC;
53-331 1.78e-43

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 153.37  E-value: 1.78e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089  53 IITNIRLPRIIVCIFGGASLGIAGLLLQTLTKNPLADSGILGINAGAGLVIALTIgTFNVSNPtilYFLPLFAMFGGLVT 132
Cdd:PRK09535   90 IVLQIRLPRILLAATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVGAVAAI-VLPLAVP---FGLQAAAFAGALVA 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 133 IFLVYLMSYRRNHNISPTrLIVTGIGISTMIsGVMISIISQSNNQKMDMIVEWLSGKITISSWTTIITFIPILILLWGLA 212
Cdd:PRK09535  166 AFGVYAIATENGRTPVAT-LLLAGVAVQTFL-GAVISYLLLHSGESLRRAVYWLMGHLHGSTWSDVEVALPVVVVGFVVL 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 213 YSRSRHLNIMNLNEQTALALGLHLKKERIYTLMLASSLAAISVVLIGNITFIGLLAGHLSRRLLGNNHKIILPSCLLIGA 292
Cdd:PRK09535  244 LAYARDLNVLLLGEEDAHTLGIEVERTKRLLLALASVVTAAAVAVAGVIGFVGLIVPHVMRLLVGPDHRILLPTSALAGA 323

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1802320089 293 IILLVSDTIGRilLVGTGIPTGLVVSIIGAPYFLWLMTK 331
Cdd:PRK09535  324 SFLVATDTVAR--SGPAEVPVGIVTAALGAPFFLYLLRT 360
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 46-333 7.46e-42

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 148.18  E-value: 7.46e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089  46 SDDAFLFIItNIRLPRIIVCIFGGASLGIAGLLLQTLTKNPLADSGILGINAGAGLVIALTIGTFNVSNPtiLYFLPLFA 125
Cdd:PRK03784   47 SPRGELFVW-QLRLPRTLAVLLVGAALAVSGAVMQALFENPLAEPGLLGVSNGAGVALVAAVLLGQGLLP--PWALSLCA 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 126 MFGGLVTIFLvyLMSYRRNHNISPTRLIVTGIGISTMISGVMISIISQSNNQKMDMIVEWLSGKITISSW---TTIITFI 202
Cdd:PRK03784  124 IAGALLITLI--LLRFARRHRLSTSRLLLAGVALGIICSALMTWAVYFSTSLDLRQLMYWMMGGFGGVDWrqsWLMLALL 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 203 PILILLwglaYSRSRHLNIMNLNEQTALALGLHLKKERIYTLMLASSLAAISVVLIGNITFIGLLAGHLSRRLLGNNHKI 282
Cdd:PRK03784  202 PVLIWL----CCQGRPLNMLALGEISARQLGLPLWFWRNLLVLATGWLVGVSVALAGAIGFIGLVIPHILRLCGLTDHRV 277

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1802320089 283 ILPSCLLIGAIILLVSDTIGRILLVGTGIPTGLVVSIIGAPYFLWLMTKVD 333
Cdd:PRK03784  278 LLPGCALAGASLLLLADIVARLALASAELPIGVVTATLGAPVFIWLLLRSH 328
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 62-329 1.92e-41

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 145.01  E-value: 1.92e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089  62 IIVCIFGGASLGIAGLLLQTLTKNPLADSGILGINAGAGLVIALTIGTFNVSNPtilYFLPLFAMFGGLVTIFLVYLMSY 141
Cdd:cd06550     1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSN---YALGAFAFAGALAIALLVLLLAS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 142 RRNHNISptRLIVTGIGISTMISGVMISIISQSNNQKMDMIVeWLSGKITISSWTTIITFIPILILLWGLAYSRSRHLNI 221
Cdd:cd06550    78 RGGLSPS--KLILIGIVLSAFFSAGVILISLLSDDSLQDLNI-WLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 222 MNLNEQTALALGLHLKKERIYTLMLASSLAAISVVLIGNITFIGLLAGHLSRRLLGNNHKIILPSCLLIGAIILLVSDTI 301
Cdd:cd06550   155 LTFDEDLAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLL 234

                         250       260
                  ....*....|....*....|....*...
gi 1802320089 302 GRILLVGtGIPTGLVVSIIGAPYFLWLM 329
Cdd:cd06550   235 SRTLLPS-ELPVGPVTALLGAPYFLYLL 261
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
37-329 4.25e-32

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 122.13  E-value: 4.25e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089  37 DVLKLISGKSDDAFLFIITNIRLPRIIVCIFGGASLGIAGLLLQTLTKNPLADSGILGINAGAGLVIALTIGTFNVSnpt 116
Cdd:PRK10440   38 QVFAALMGDAPRSMTMVVTEWRLPRVLMALLIGAALGVSGAIFQSLMRNPLGSPDVMGFNTGAWSGVLVAMVLFGQD--- 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 117 iLYFLPLFAMFGGLVTIFLVYLMSYRRnhNISPTRLIVTGIGISTMISGVMISIISQSNNQKMDMIVEWLSGKITISSWT 196
Cdd:PRK10440  115 -LTAIALAAMAGGIVTSLLVWLLAWRN--GIDTFRLIIIGIGVRAMLVAFNTWLLLKASLETALTAGLWNAGSLNGLTWA 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802320089 197 TIITFIPILILLWGLAYSRSRHLNIMNLNEQTALALGLHLKKERIYTLMLASSLAAISVVLIGNITFIGLLAGHLSRRLL 276
Cdd:PRK10440  192 KTSPSAPIIILMLIAAALLVRRMRLLEMGDDTACALGVSVERSRLLLMLVAVVLTAAATALAGPISFIALVAPHIARRLS 271

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1802320089 277 GNNHKIILPSClLIGAIILLVSDTIGRILLVGTGIPTGLVVSIIGAPYFLWLM 329
Cdd:PRK10440  272 GTARWGLTQAA-LCGALLLLAADLCAQQLFMPYQLPVGVVTVSLGGIYLIVLL 323
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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