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Conserved domains on  [gi|1832221304|gb|KAF4103970|]
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hypothetical protein G5714_014957 [Onychostoma macrolepis]

Protein Classification

Apt family protein( domain architecture ID 10785556)

Apt family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Apt COG0503
Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide ...
 30-175 1.72e-39

Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide transport and metabolism]; Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein is part of the Pathway/BioSystem: Purine salvage


:

Pssm-ID: 440269  Cd Length: 171  Bit Score: 132.89  E-value: 1.72e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832221304  30 WLDPSRLYCNSQALSDCVKDLLKPFQNETIDLVAGIDAMGFILGSAVAKTLRKGFLAIRKAGHLCVQTRTRDY-SDYsGR 108
Cdd:COG0503    20 FRDITPLLGDPELFRAAGDELAERFADKGIDKVVGIEARGFILAAALAYALGVPFVPARKPGKLPGETVSEEYdLEY-GT 98

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1832221304 109 EKLMEVRVDVLKPGLRVLIVDQWIETGGTMRAAIKLVENQGATVVGIAAVaIENSE-GGKWLKENYKY 175
Cdd:COG0503    99 GDTLELHKDALKPGDRVLIVDDLLATGGTAKAAIKLVEEAGAEVVGIAFL-IELGFlGGREKLRDYPV 165
 
Name Accession Description Interval E-value
Apt COG0503
Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide ...
 30-175 1.72e-39

Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide transport and metabolism]; Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440269  Cd Length: 171  Bit Score: 132.89  E-value: 1.72e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832221304  30 WLDPSRLYCNSQALSDCVKDLLKPFQNETIDLVAGIDAMGFILGSAVAKTLRKGFLAIRKAGHLCVQTRTRDY-SDYsGR 108
Cdd:COG0503    20 FRDITPLLGDPELFRAAGDELAERFADKGIDKVVGIEARGFILAAALAYALGVPFVPARKPGKLPGETVSEEYdLEY-GT 98

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1832221304 109 EKLMEVRVDVLKPGLRVLIVDQWIETGGTMRAAIKLVENQGATVVGIAAVaIENSE-GGKWLKENYKY 175
Cdd:COG0503    99 GDTLELHKDALKPGDRVLIVDDLLATGGTAKAAIKLVEEAGAEVVGIAFL-IELGFlGGREKLRDYPV 165
PRK02304 PRK02304
adenine phosphoribosyltransferase; Provisional
 36-161 4.42e-37

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 235028  Cd Length: 175  Bit Score: 126.73  E-value: 4.42e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832221304  36 LYCNSQALSDCVKDLLKPFQNETIDLVAGIDAMGFILGSAVAKTLRKGFLAIRKAGHLCVQTRTRDYS-DYsGREKLmEV 114
Cdd:PRK02304   29 LLADPEAFREVIDALVERYKDADIDKIVGIEARGFIFGAALAYKLGIGFVPVRKPGKLPRETISESYElEY-GTDTL-EI 106

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1832221304 115 RVDVLKPGLRVLIVDQWIETGGTMRAAIKLVENQGATVVGIAAVaIE 161
Cdd:PRK02304  107 HKDAIKPGDRVLIVDDLLATGGTLEAAIKLLERLGAEVVGAAFV-IE 152
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 59-171 1.71e-21

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 85.53  E-value: 1.71e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832221304  59 IDLVAGIDAMGFILGSAVAKTLRKGFLAIRKAGHLCVQTRTRDYSdysgreklMEVRVDVLKPGLRVLIVDQWIETGGTM 138
Cdd:cd06223    16 PDVVVGILRGGLPLAAALARALGLPLAFIRKERKGPGRTPSEPYG--------LELPLGGDVKGKRVLLVDDVIATGGTL 87

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1832221304 139 RAAIKLVENQGATVVGIAAVaIENSEGGKWLKE 171
Cdd:cd06223    88 LAAIELLKEAGAKVVGVAVL-LDKPEGGARELA 119
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 56-170 2.09e-10

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 56.60  E-value: 2.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832221304  56 NETIDLVAGIDAMGFILGSAVAKTLRKGFLAIRKaghlcvqtrTRDYSDYSGREKLMEVRVDVlkPGLRVLIVDQWIETG 135
Cdd:pfam00156  27 GGKPDVVVGILRGGLPFAGILARRLDVPLAFVRK---------VSYNPDTSEVMKTSSALPDL--KGKTVLIVDDILDTG 95

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1832221304 136 GTMRAAIKLVENQGATVVGIAAVAIENSEGGKWLK 170
Cdd:pfam00156  96 GTLLKVLELLKNVGPKEVKIAVLIDKPAGTEPKDK 130
pyrE_Therm TIGR01367
orotate phosphoribosyltransferase, Thermus family; This model represents a distinct clade of ...
 59-167 1.46e-07

orotate phosphoribosyltransferase, Thermus family; This model represents a distinct clade of orotate phosphoribosyltransferases. Members include the experimentally determined example from Thermus aquaticus and additional examples from Caulobacter crescentus, Helicobacter pylori, Mesorhizobium loti, and related species. [Purines, pyrimidines, nucleosides, and nucleotides, Pyrimidine ribonucleotide biosynthesis]


Pssm-ID: 273579  Cd Length: 187  Bit Score: 49.40  E-value: 1.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832221304  59 IDLVAGIDAMGFILGSAVAKTLRKGFLAIRKAGhlcvqtrtrdysdysgreKLMEVRVDV-LKPGLRVLIVDQWIETGGT 137
Cdd:TIGR01367  59 VDFIVGPAMGGVILGYEVARQLSVRSIFAEREG------------------GGMKLRRGFaVKPGEKFVAVEDVVTTGGS 120

                          90       100       110
                  ....*....|....*....|....*....|
gi 1832221304 138 MRAAIKLVENQGATVVGIAAVaIENSEGGK 167
Cdd:TIGR01367 121 LLEAIRAIEGQGGQVVGLACI-IDRSQGGK 149
 
Name Accession Description Interval E-value
Apt COG0503
Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide ...
 30-175 1.72e-39

Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide transport and metabolism]; Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440269  Cd Length: 171  Bit Score: 132.89  E-value: 1.72e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832221304  30 WLDPSRLYCNSQALSDCVKDLLKPFQNETIDLVAGIDAMGFILGSAVAKTLRKGFLAIRKAGHLCVQTRTRDY-SDYsGR 108
Cdd:COG0503    20 FRDITPLLGDPELFRAAGDELAERFADKGIDKVVGIEARGFILAAALAYALGVPFVPARKPGKLPGETVSEEYdLEY-GT 98

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1832221304 109 EKLMEVRVDVLKPGLRVLIVDQWIETGGTMRAAIKLVENQGATVVGIAAVaIENSE-GGKWLKENYKY 175
Cdd:COG0503    99 GDTLELHKDALKPGDRVLIVDDLLATGGTAKAAIKLVEEAGAEVVGIAFL-IELGFlGGREKLRDYPV 165
PRK02304 PRK02304
adenine phosphoribosyltransferase; Provisional
 36-161 4.42e-37

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 235028  Cd Length: 175  Bit Score: 126.73  E-value: 4.42e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832221304  36 LYCNSQALSDCVKDLLKPFQNETIDLVAGIDAMGFILGSAVAKTLRKGFLAIRKAGHLCVQTRTRDYS-DYsGREKLmEV 114
Cdd:PRK02304   29 LLADPEAFREVIDALVERYKDADIDKIVGIEARGFIFGAALAYKLGIGFVPVRKPGKLPRETISESYElEY-GTDTL-EI 106

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1832221304 115 RVDVLKPGLRVLIVDQWIETGGTMRAAIKLVENQGATVVGIAAVaIE 161
Cdd:PRK02304  107 HKDAIKPGDRVLIVDDLLATGGTLEAAIKLLERLGAEVVGAAFV-IE 152
PLN02293 PLN02293
adenine phosphoribosyltransferase
 32-158 9.17e-26

adenine phosphoribosyltransferase


Pssm-ID: 177930  Cd Length: 187  Bit Score: 98.21  E-value: 9.17e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832221304  32 DPSRLYCNSQALSDCVKDLLKPFQNETIDLVAGIDAMGFILGSAVAKTLRKGFLAIRKAGHLCVQTRTRDYSDYSGREKL 111
Cdd:PLN02293   36 DITTLLLDPKAFKDTIDLFVERYRDMGISVVAGIEARGFIFGPPIALAIGAKFVPLRKPGKLPGEVISEEYVLEYGTDCL 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1832221304 112 mEVRVDVLKPGLRVLIVDQWIETGGTMRAAIKLVENQGATVVGIAAV 158
Cdd:PLN02293  116 -EMHVGAVEPGERALVIDDLIATGGTLCAAINLLERAGAEVVECACV 161
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 59-171 1.71e-21

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 85.53  E-value: 1.71e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832221304  59 IDLVAGIDAMGFILGSAVAKTLRKGFLAIRKAGHLCVQTRTRDYSdysgreklMEVRVDVLKPGLRVLIVDQWIETGGTM 138
Cdd:cd06223    16 PDVVVGILRGGLPLAAALARALGLPLAFIRKERKGPGRTPSEPYG--------LELPLGGDVKGKRVLLVDDVIATGGTL 87

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1832221304 139 RAAIKLVENQGATVVGIAAVaIENSEGGKWLKE 171
Cdd:cd06223    88 LAAIELLKEAGAKVVGVAVL-LDKPEGGARELA 119
pyrE PRK00455
orotate phosphoribosyltransferase; Validated
 59-158 1.14e-12

orotate phosphoribosyltransferase; Validated


Pssm-ID: 234771  Cd Length: 202  Bit Score: 63.64  E-value: 1.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832221304  59 IDLVAGIdAMGFI-LGSAVAKTLRKGFLAIRKA--GHlcvqtrtrdysdysGREKLMEVRvdvLKPGLRVLIVDQWIETG 135
Cdd:PRK00455   65 FDVVAGP-ATGGIpLAAAVARALDLPAIFVRKEakDH--------------GEGGQIEGR---RLFGKRVLVVEDVITTG 126

                          90       100
                  ....*....|....*....|...
gi 1832221304 136 GTMRAAIKLVENQGATVVGIAAV 158
Cdd:PRK00455  127 GSVLEAVEAIRAAGAEVVGVAVI 149
PyrE COG0461
Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate ...
 41-158 6.14e-12

Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440229  Cd Length: 201  Bit Score: 61.71  E-value: 6.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832221304  41 QALSDCVKDLLKPFqnetiDLVAGIdAMGFI-LGSAVAKTLRKGFLAIRKA--GHlcvqtrtrdysdysGREKLMEVRvd 117
Cdd:COG0461    51 EALAELIKELGPEF-----DAVAGP-ATGGIpLAAAVARALGLPAIFVRKEakDH--------------GTGGQIEGG-- 108

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1832221304 118 vLKPGLRVLIVDQWIETGGTMRAAIKLVENQGATVVGIAAV 158
Cdd:COG0461   109 -LLPGERVLVVEDVITTGGSVLEAVEALREAGAEVVGVAVI 148
PRK12560 PRK12560
adenine phosphoribosyltransferase; Provisional
 41-175 1.18e-10

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 183595  Cd Length: 187  Bit Score: 57.87  E-value: 1.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832221304  41 QALSDCVKDLLKpFQNETIDLVAGIDAMGFILGSAVAKTlrkGFLAIRKAGHLCVQTRTRDYSDYS-GREKL-MEVRVDV 118
Cdd:PRK12560   35 KVLKETAKEIIK-YIDKDIDKIVTEEDKGAPLATPVSLL---SGKPLAMARWYPYSLSELNYNVVEiGSEYFeGVVYLNG 110

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1832221304 119 LKPGLRVLIVDQWIETGGTMRAAIKLVENQGATVVG-IAAVAIENSEGGKWLKENYKY 175
Cdd:PRK12560  111 IEKGDRVAIIDDTLSTGGTVIALIKAIENSGGIVSDvICVIEKTQNNGRKKLFTQTGI 168
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 56-170 2.09e-10

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 56.60  E-value: 2.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832221304  56 NETIDLVAGIDAMGFILGSAVAKTLRKGFLAIRKaghlcvqtrTRDYSDYSGREKLMEVRVDVlkPGLRVLIVDQWIETG 135
Cdd:pfam00156  27 GGKPDVVVGILRGGLPFAGILARRLDVPLAFVRK---------VSYNPDTSEVMKTSSALPDL--KGKTVLIVDDILDTG 95

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1832221304 136 GTMRAAIKLVENQGATVVGIAAVAIENSEGGKWLK 170
Cdd:pfam00156  96 GTLLKVLELLKNVGPKEVKIAVLIDKPAGTEPKDK 130
PRK02277 PRK02277
orotate phosphoribosyltransferase-like protein; Provisional
 32-159 8.15e-08

orotate phosphoribosyltransferase-like protein; Provisional


Pssm-ID: 235023 [Multi-domain]  Cd Length: 200  Bit Score: 50.25  E-value: 8.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832221304  32 DPSRLYCNSQALSDCVKDllkpfQNETIDLVAGIDAMGFILGSAVAKTLRKGFLAIRKAGHLCVQTR------TRDYSDY 105
Cdd:PRK02277   64 SSSRLRYIASAMADMLEK-----EDEEVDVVVGIAKSGVPLATLVADELGKDLAIYHPKKWDHGEGEkktgsfSRNFASV 138

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1832221304 106 SGReklmevrvdvlkpglRVLIVDQWIETGGTMRAAIKLVENQGATVVGIAAVA 159
Cdd:PRK02277  139 EGK---------------RCVIVDDVITSGTTMKETIEYLKEHGGKPVAVVVLI 177
pyrE_Therm TIGR01367
orotate phosphoribosyltransferase, Thermus family; This model represents a distinct clade of ...
 59-167 1.46e-07

orotate phosphoribosyltransferase, Thermus family; This model represents a distinct clade of orotate phosphoribosyltransferases. Members include the experimentally determined example from Thermus aquaticus and additional examples from Caulobacter crescentus, Helicobacter pylori, Mesorhizobium loti, and related species. [Purines, pyrimidines, nucleosides, and nucleotides, Pyrimidine ribonucleotide biosynthesis]


Pssm-ID: 273579  Cd Length: 187  Bit Score: 49.40  E-value: 1.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832221304  59 IDLVAGIDAMGFILGSAVAKTLRKGFLAIRKAGhlcvqtrtrdysdysgreKLMEVRVDV-LKPGLRVLIVDQWIETGGT 137
Cdd:TIGR01367  59 VDFIVGPAMGGVILGYEVARQLSVRSIFAEREG------------------GGMKLRRGFaVKPGEKFVAVEDVVTTGGS 120

                          90       100       110
                  ....*....|....*....|....*....|
gi 1832221304 138 MRAAIKLVENQGATVVGIAAVaIENSEGGK 167
Cdd:TIGR01367 121 LLEAIRAIEGQGGQVVGLACI-IDRSQGGK 149
PRK08558 PRK08558
adenine phosphoribosyltransferase; Provisional
 67-173 6.29e-07

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 181466 [Multi-domain]  Cd Length: 238  Bit Score: 48.06  E-value: 6.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832221304  67 AMGFILGS--AVAKTLRKgfLAIRKAghlcVQTRTRDYSdysGREKLMEVRVDVLKPGLRVLIVDQWIETGGTMRAAIKL 144
Cdd:PRK08558  128 AIASYFGAdlVYAKKSKE--TGVEKF----YEEYQRLAS---GIEVTLYLPASALKKGDRVLIVDDIIRSGETQRALLDL 198

                          90       100
                  ....*....|....*....|....*....
gi 1832221304 145 VENQGATVVGIAAVAIENSEGGKWLKENY 173
Cdd:PRK08558  199 ARQAGADVVGVFFLIAVGEVGIDRAREET 227
PRK09219 PRK09219
xanthine phosphoribosyltransferase; Validated
 113-171 8.88e-07

xanthine phosphoribosyltransferase; Validated


Pssm-ID: 181705  Cd Length: 189  Bit Score: 47.09  E-value: 8.88e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1832221304 113 EVRV--DVLKPGLRVLIVDQWIETGGTMRAAIKLVENQGATVVGIAAVaIENS--EGGKWLKE 171
Cdd:PRK09219  106 TVSVskKFLSEGDRVLIIDDFLANGQAALGLIDIIEQAGAKVAGIGIV-IEKSfqDGRKLLEE 167
PRK07322 PRK07322
adenine phosphoribosyltransferase; Provisional
 122-161 2.24e-06

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 180928  Cd Length: 178  Bit Score: 46.12  E-value: 2.24e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1832221304 122 GLRVLIVDQWIETGGTMRAAIKLVENQGATVVGIAAVAIE 161
Cdd:PRK07322  120 GKRVAIVDDVVSTGGTLTALERLVERAGGQVVAKAAIFAE 159
PRK06031 PRK06031
phosphoribosyltransferase; Provisional
 42-165 5.22e-06

phosphoribosyltransferase; Provisional


Pssm-ID: 235678  Cd Length: 233  Bit Score: 45.51  E-value: 5.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832221304  42 ALSDCVKDLLKPFQnetIDLVAGIDAMGFILGSAVAktlrkgflaiRKAGHlcvqTR------TRDY---SDYS------ 106
Cdd:PRK06031   71 ALAEHLAEKARAFD---PDVVAGLPTLGLTLAAAVA----------RKLGH----TRyvplgtSRKFwyrDELSvplssi 133

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1832221304 107 ---GREKLMEV--RVDVLKPGLRVLIVDQWIETGGTMRAAIKLVENQGATVVGIAAvAIENSEG 165
Cdd:PRK06031  134 ttpDQGKRLYIdpRMLPLLEGRRVALIDDVISSGASIVAGLRLLAACGIEPAGIGA-AMLQSER 196
PRK00934 PRK00934
ribose-phosphate pyrophosphokinase; Provisional
 105-158 6.00e-06

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 234868 [Multi-domain]  Cd Length: 285  Bit Score: 45.67  E-value: 6.00e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1832221304 105 YSGRE-KLMEVRVDVlkPGLRVLIVDQWIETGGTMRAAIKLVENQGATVVGIAAV 158
Cdd:PRK00934  188 ISPTEvEIAPKNLDV--KGKDVLIVDDIISTGGTMATAIKILKEQGAKKVYVACV 240
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 75-158 9.91e-05

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 41.88  E-value: 9.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832221304  75 AVAKTLRKGFLAIRKaghlcvqtrTRDYSDYSGREklMEVRVDVlkPGLRVLIVDQWIETGGTMRAAIKLVENQGATVVG 154
Cdd:TIGR01251 176 KVADALGCPLAIIDK---------RRISATNEVEV--MNLVGDV--EGKDVVIVDDIIDTGGTIAKAAEILKSAGAKRVI 242


                  ....
gi 1832221304 155 IAAV 158
Cdd:TIGR01251 243 AAAT 246
Hpt1 COG2236
Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; Hypoxanthine ...
 69-158 4.93e-04

Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; Hypoxanthine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 441837 [Multi-domain]  Cd Length: 153  Bit Score: 39.06  E-value: 4.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832221304  69 GFILGSAVAKTL-RKGFLAIRkaghlcvqtrTRDYSDYSGREKLMEVR--VDVLKPGLRVLIVDQWIETGGTMRAAIKLV 145
Cdd:COG2236    42 GLVPARILADALgVPDLASIR----------VSSYTGTAKRLEEPVVKgpLDEDLAGKRVLIVDDVADTGRTLEAVRDLL 111

                          90
                  ....*....|...
gi 1832221304 146 ENQGATVVGIAAV 158
Cdd:COG2236   112 KEAGPAEVRTAVL 124
PLN02541 PLN02541
uracil phosphoribosyltransferase
 75-160 6.01e-04

uracil phosphoribosyltransferase


Pssm-ID: 215297  Cd Length: 244  Bit Score: 39.38  E-value: 6.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832221304  75 AVAKTLRKGFLAIRKAGHLCVQTRTRdYSDYSGREKLMEVRV------DVLKPGLRVLIVDQWIETGGTMRAAIKLVENQ 148
Cdd:PLN02541  105 AVVPILRAGLVLLEHASSVLPATKTY-HLGFVRDEETLQPSMylnklpDKFPEGSRVLVVDPMLATGGTIVAAIDELVSR 183

                          90
                  ....*....|..
gi 1832221304 149 GATVVGIAAVAI 160
Cdd:PLN02541  184 GASVEQIRVVCA 195
COG1926 COG1926
Predicted phosphoribosyltransferase [General function prediction only];
124-159 6.05e-04

Predicted phosphoribosyltransferase [General function prediction only];


Pssm-ID: 441529  Cd Length: 209  Bit Score: 39.29  E-value: 6.05e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1832221304 124 RVLIVDQWIETGGTMRAAIKLVENQGATVVGIAA-VA 159
Cdd:COG1926   123 TVILVDDGIATGATMRAALRALRRQGPARIVVAVpVA 159
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 74-158 7.26e-03

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 36.19  E-value: 7.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832221304  74 SAVAKTLRKGFLAIRKaghlcvqTRTRDysdysgRE-KLMEVRVDVlkPGLRVLIVDQWIETGGTMRAAIKLVENQGATV 152
Cdd:COG0462   177 RAFAKRLGAPLAIIDK-------RRPGA------NEvEVMNIIGDV--EGKTCIIVDDMIDTGGTLVEAAEALKEAGAKS 241


                  ....*.
gi 1832221304 153 VgIAAV 158
Cdd:COG0462   242 V-YAAA 246
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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