OPT family oligopeptide transporter may be involved in the translocation of oligopeptides such as tetra- and pentapeptides across the cellular membrane in an energy-dependent manner
OPT oligopeptide transporter protein; The OPT family of oligopeptide transporters is distinct ...
53-733
0e+00
OPT oligopeptide transporter protein; The OPT family of oligopeptide transporters is distinct from the ABC pfam00005 and PTR pfam00854 transporter families. OPT transporters were first recognized in fungi (Candida albicans and Schizosaccharomyces pombe), but this alignment also includes orthologues from Arabidopsis thaliana. OPT transporters are thought to have 12-14 transmembrane domains and contain the following motif: SPYxEVRxxVxxxDDP.
The actual alignment was detected with superfamily member TIGR00727:
Pssm-ID: 449333 Cd Length: 681 Bit Score: 636.53 E-value: 0e+00
small oligopeptide transporter, OPT family; This model represents a family of transporters of ...
53-733
0e+00
small oligopeptide transporter, OPT family; This model represents a family of transporters of small oligopeptides, demonstrated experimentally in three different species of yeast. A set of related proteins from the plant Arabidopsis thaliana forms an outgroup to the yeast set by neighbor joining analysis but is remarkably well conserved and is predicted here to have equivalent function. [Transport and binding proteins, Amino acids, peptides and amines]
Pssm-ID: 129810 Cd Length: 681 Bit Score: 636.53 E-value: 0e+00
OPT oligopeptide transporter protein; The OPT family of oligopeptide transporters is distinct ...
75-727
4.44e-166
OPT oligopeptide transporter protein; The OPT family of oligopeptide transporters is distinct from the ABC pfam00005 and PTR pfam00854 transporter families. OPT transporters were first recognized in fungi (Candida albicans and Schizosaccharomyces pombe), but this alignment also includes orthologues from Arabidopsis thaliana. OPT transporters are thought to have 12-14 transmembrane domains and contain the following motif: SPYxEVRxxVxxxDDP.
Pssm-ID: 367370 [Multi-domain] Cd Length: 614 Bit Score: 492.99 E-value: 4.44e-166
small oligopeptide transporter, OPT family; This model represents a family of transporters of ...
53-733
0e+00
small oligopeptide transporter, OPT family; This model represents a family of transporters of small oligopeptides, demonstrated experimentally in three different species of yeast. A set of related proteins from the plant Arabidopsis thaliana forms an outgroup to the yeast set by neighbor joining analysis but is remarkably well conserved and is predicted here to have equivalent function. [Transport and binding proteins, Amino acids, peptides and amines]
Pssm-ID: 129810 Cd Length: 681 Bit Score: 636.53 E-value: 0e+00
OPT oligopeptide transporter protein; The OPT family of oligopeptide transporters is distinct ...
75-727
4.44e-166
OPT oligopeptide transporter protein; The OPT family of oligopeptide transporters is distinct from the ABC pfam00005 and PTR pfam00854 transporter families. OPT transporters were first recognized in fungi (Candida albicans and Schizosaccharomyces pombe), but this alignment also includes orthologues from Arabidopsis thaliana. OPT transporters are thought to have 12-14 transmembrane domains and contain the following motif: SPYxEVRxxVxxxDDP.
Pssm-ID: 367370 [Multi-domain] Cd Length: 614 Bit Score: 492.99 E-value: 4.44e-166
oligopeptide transporter, OPT superfamily; This superfamily has two main branches. One branch ...
59-727
3.71e-154
oligopeptide transporter, OPT superfamily; This superfamily has two main branches. One branch contains a tetrapeptide transporter demonstrated experimentally in three different species of yeast. The other family contains EspB of Myxococcus xanthus, a protein required for normal rather than delayed sporulation after cellular aggregation; its role is unknown but is compatible with transport of a signalling molecule. Homology between the two branches of the superfamily is seen most easily at the ends of the protein. The central regions are poorly conserved within each branch and may not be homologous between branches.
Pssm-ID: 273236 Cd Length: 657 Bit Score: 463.84 E-value: 3.71e-154
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.
To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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(labeled illustration) Four types of hits can be shown, as available,
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specific hits meet or exceed a domain-specific e-value threshold
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and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
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Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
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