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Conserved domains on  [gi|1848333883|gb|KAF5002942|]
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hypothetical protein FGRMN_1 [Fusarium graminum]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 10573454)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0003677|GO:0008270|GO:0003700
PubMed:  11179890|12665246|11361095|10940247
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-C2H2_2 pfam12756
C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger ...
 214-311 3.05e-41

C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger domain.


:

Pssm-ID: 463690  Cd Length: 98  Bit Score: 143.58  E-value: 3.05e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848333883 214 CLFCNYSSPSIPLNTHHMERFHGMFIPEKKYLVDIDGLLQQLQDKIRQHHQCLYCDKVKSSMFGVQTHMRDTGHCKIPYE 293
Cdd:pfam12756   1 CLFCGHTSSTVEENLEHMFKSHGFFIPEREYLVDLEGLLNYLREKIGLGNECLYCGKQFKSLEALRQHMRDKGHCKIPYE 80

                          90
                  ....*....|....*...
gi 1848333883 294 TEREQLRIGDFYDFRSTY 311
Cdd:pfam12756  81 SEEEWLEIAEFYDFSSSY 98
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 81-104 2.26e-05

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


:

Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 41.39  E-value: 2.26e-05
                          10        20
                  ....*....|....*....|....
gi 1848333883  81 CDICEKTYYSENAFQNHLSSQKHK 104
Cdd:pfam12171   4 CVLCDKYFKSENALQNHLKSKKHK 27
PTZ00448 super family cl29187
hypothetical protein; Provisional
 16-59 1.06e-03

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PTZ00448:

Pssm-ID: 185627 [Multi-domain]  Cd Length: 373  Bit Score: 41.56  E-value: 1.06e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1848333883  16 CNTCQVAYRNIDLQKGHMKSDWHRYNLKRRVASLPPISADVFTE 59
Cdd:PTZ00448  317 CRKCNIQLMDHNAFKQHYRSEWHIFNTKRNARKMEPISEEEFLE 360
 
Name Accession Description Interval E-value
zf-C2H2_2 pfam12756
C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger ...
 214-311 3.05e-41

C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger domain.


Pssm-ID: 463690  Cd Length: 98  Bit Score: 143.58  E-value: 3.05e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848333883 214 CLFCNYSSPSIPLNTHHMERFHGMFIPEKKYLVDIDGLLQQLQDKIRQHHQCLYCDKVKSSMFGVQTHMRDTGHCKIPYE 293
Cdd:pfam12756   1 CLFCGHTSSTVEENLEHMFKSHGFFIPEREYLVDLEGLLNYLREKIGLGNECLYCGKQFKSLEALRQHMRDKGHCKIPYE 80

                          90
                  ....*....|....*...
gi 1848333883 294 TEREQLRIGDFYDFRSTY 311
Cdd:pfam12756  81 SEEEWLEIAEFYDFSSSY 98
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 81-104 2.26e-05

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 41.39  E-value: 2.26e-05
                          10        20
                  ....*....|....*....|....
gi 1848333883  81 CDICEKTYYSENAFQNHLSSQKHK 104
Cdd:pfam12171   4 CVLCDKYFKSENALQNHLKSKKHK 27
PTZ00448 PTZ00448
hypothetical protein; Provisional
 16-59 1.06e-03

hypothetical protein; Provisional


Pssm-ID: 185627 [Multi-domain]  Cd Length: 373  Bit Score: 41.56  E-value: 1.06e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1848333883  16 CNTCQVAYRNIDLQKGHMKSDWHRYNLKRRVASLPPISADVFTE 59
Cdd:PTZ00448  317 CRKCNIQLMDHNAFKQHYRSEWHIFNTKRNARKMEPISEEEFLE 360
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 81-107 6.05e-03

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 34.54  E-value: 6.05e-03
                           10        20
                   ....*....|....*....|....*..
gi 1848333883   81 CDICEKTYYSENAFQNHLSSQKHKAKE 107
Cdd:smart00451   6 CKLCNVTFTDEISVEAHLKGKKHKKNV 32
 
Name Accession Description Interval E-value
zf-C2H2_2 pfam12756
C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger ...
 214-311 3.05e-41

C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger domain.


Pssm-ID: 463690  Cd Length: 98  Bit Score: 143.58  E-value: 3.05e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848333883 214 CLFCNYSSPSIPLNTHHMERFHGMFIPEKKYLVDIDGLLQQLQDKIRQHHQCLYCDKVKSSMFGVQTHMRDTGHCKIPYE 293
Cdd:pfam12756   1 CLFCGHTSSTVEENLEHMFKSHGFFIPEREYLVDLEGLLNYLREKIGLGNECLYCGKQFKSLEALRQHMRDKGHCKIPYE 80

                          90
                  ....*....|....*...
gi 1848333883 294 TEREQLRIGDFYDFRSTY 311
Cdd:pfam12756  81 SEEEWLEIAEFYDFSSSY 98
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 81-104 2.26e-05

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 41.39  E-value: 2.26e-05
                          10        20
                  ....*....|....*....|....
gi 1848333883  81 CDICEKTYYSENAFQNHLSSQKHK 104
Cdd:pfam12171   4 CVLCDKYFKSENALQNHLKSKKHK 27
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 81-103 1.87e-04

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 38.63  E-value: 1.87e-04
                          10        20
                  ....*....|....*....|...
gi 1848333883  81 CDICEKTYYSENAFQNHLSSQKH 103
Cdd:pfam12874   3 CELCNVTFNSESQLKSHLQGKKH 25
PTZ00448 PTZ00448
hypothetical protein; Provisional
 16-59 1.06e-03

hypothetical protein; Provisional


Pssm-ID: 185627 [Multi-domain]  Cd Length: 373  Bit Score: 41.56  E-value: 1.06e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1848333883  16 CNTCQVAYRNIDLQKGHMKSDWHRYNLKRRVASLPPISADVFTE 59
Cdd:PTZ00448  317 CRKCNIQLMDHNAFKQHYRSEWHIFNTKRNARKMEPISEEEFLE 360
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 81-107 6.05e-03

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 34.54  E-value: 6.05e-03
                           10        20
                   ....*....|....*....|....*..
gi 1848333883   81 CDICEKTYYSENAFQNHLSSQKHKAKE 107
Cdd:smart00451   6 CKLCNVTFTDEISVEAHLKGKKHKKNV 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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