hypothetical protein GE061_004208 [Apolygus lucorum]
Protein Classification
CUE domain-containing protein( domain architecture ID 10406393)
CUE domain-containing protein may bind ubiquitin and function in monoubiquitylation
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| CUE | cd14279 | CUE domain found in ubiquitin-binding CUE proteins; This family includes many coupling of ... |
234-271 | 3.95e-04 | ||
CUE domain found in ubiquitin-binding CUE proteins; This family includes many coupling of ubiquitin conjugation to endoplasmic reticulum degradation (CUE) domain containing proteins that are characterized by an FP and a di-leucine-like sequence and bind to monoubiquitin with varying affinities. Some higher eukaryotic CUE domain proteins do not bind monoubiquitin efficiently, since they carry LP, rather than FP among CUE domains. CUE domains form three-helix bundle structures and are distantly related to the ubiquitin-associated (UBA) domains which are widely occurring ubiquitin-binding motifs found in a broad range of cellular proteins in species ranging from yeast to human. The majority of family members contain one CUE domain, but some family members from fungi harbor two CUE domains. : Pssm-ID: 270465 Cd Length: 38 Bit Score: 37.83 E-value: 3.95e-04
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| UBA_like_SF super family | cl21463 | UBA domain-like superfamily; The ubiquitin-associated (UBA) domain-like superfamily contains ... |
157-196 | 2.55e-03 | ||
UBA domain-like superfamily; The ubiquitin-associated (UBA) domain-like superfamily contains alpha-helical structural homology ubiquitin-binding domains, including UBA domains and coupling of ubiquitin conjugation to endoplasmic reticulum degradation (CUE) domains which share a common three-helical bundle architecture. UBA domains are commonly occurring sequence motifs found in proteins involved in ubiquitin-mediated proteolysis. They contribute to ubiquitin (Ub) binding or ubiquitin-like (UbL) domain binding. However, some kinds of UBA domains can only bind the UbL domain, but not the Ub domain. UBA domains are normally comprised of compact three-helix bundles which contain a conserved GF/Y-loop. They can bind polyubiquitin with high affinity. They also bind monoubiquitin and other proteins. Most UBA domain-containing proteins have one UBA domain, but some harbor two or three UBA domains. CUE domain containing proteins are characterized by an FP and a di-leucine-like sequence and bind to monoubiquitin with varying affinities. Some higher eukaryotic CUE domain proteins do not bind monoubiquitin efficiently, since they carry LP, rather than FP among CUE domains. This superfamily also includes many UBA-like domains found in AMP-activated protein kinase (AMPK) related kinases, the NXF family of mRNA nuclear export factors, elongation factor Ts (EF-Ts), nascent polypeptide-associated complex subunit alpha (NACA) and similar proteins. Although many UBA-like domains may have a conserved TG but not GF/Y-loop, they still show a high level of structural and sequence similarity with three-helical ubiquitin binding domains. The actual alignment was detected with superfamily member cd14373: Pssm-ID: 473871 Cd Length: 41 Bit Score: 35.62 E-value: 2.55e-03
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| Name | Accession | Description | Interval | E-value | ||
| CUE | cd14279 | CUE domain found in ubiquitin-binding CUE proteins; This family includes many coupling of ... |
234-271 | 3.95e-04 | ||
CUE domain found in ubiquitin-binding CUE proteins; This family includes many coupling of ubiquitin conjugation to endoplasmic reticulum degradation (CUE) domain containing proteins that are characterized by an FP and a di-leucine-like sequence and bind to monoubiquitin with varying affinities. Some higher eukaryotic CUE domain proteins do not bind monoubiquitin efficiently, since they carry LP, rather than FP among CUE domains. CUE domains form three-helix bundle structures and are distantly related to the ubiquitin-associated (UBA) domains which are widely occurring ubiquitin-binding motifs found in a broad range of cellular proteins in species ranging from yeast to human. The majority of family members contain one CUE domain, but some family members from fungi harbor two CUE domains. Pssm-ID: 270465 Cd Length: 38 Bit Score: 37.83 E-value: 3.95e-04
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| CUE_Cue3p_like | cd14373 | CUE domain found in yeast ubiquitin-binding protein CUE3 (Cue3p) and similar proteins; Cue3p, ... |
157-196 | 2.55e-03 | ||
CUE domain found in yeast ubiquitin-binding protein CUE3 (Cue3p) and similar proteins; Cue3p, also called coupling of ubiquitin conjugation to ER degradation protein 3, is encoded by the open reading frame (ORF) YGL110C. It is involved in the intramolecular monoubiquitination that serves as a regulatory signal in a variety of cellular processes in yeast. Cue3p contains a CUE domain. Pssm-ID: 270556 Cd Length: 41 Bit Score: 35.62 E-value: 2.55e-03
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| CUE | smart00546 | Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also ... |
155-194 | 7.87e-03 | ||
Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2. Ponting (Biochem. J.) "Proteins of the Endoplasmic reticulum" (in press) Pssm-ID: 214715 Cd Length: 43 Bit Score: 34.39 E-value: 7.87e-03
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| Name | Accession | Description | Interval | E-value | ||
| CUE | cd14279 | CUE domain found in ubiquitin-binding CUE proteins; This family includes many coupling of ... |
234-271 | 3.95e-04 | ||
CUE domain found in ubiquitin-binding CUE proteins; This family includes many coupling of ubiquitin conjugation to endoplasmic reticulum degradation (CUE) domain containing proteins that are characterized by an FP and a di-leucine-like sequence and bind to monoubiquitin with varying affinities. Some higher eukaryotic CUE domain proteins do not bind monoubiquitin efficiently, since they carry LP, rather than FP among CUE domains. CUE domains form three-helix bundle structures and are distantly related to the ubiquitin-associated (UBA) domains which are widely occurring ubiquitin-binding motifs found in a broad range of cellular proteins in species ranging from yeast to human. The majority of family members contain one CUE domain, but some family members from fungi harbor two CUE domains. Pssm-ID: 270465 Cd Length: 38 Bit Score: 37.83 E-value: 3.95e-04
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| CUE_Cue3p_like | cd14373 | CUE domain found in yeast ubiquitin-binding protein CUE3 (Cue3p) and similar proteins; Cue3p, ... |
157-196 | 2.55e-03 | ||
CUE domain found in yeast ubiquitin-binding protein CUE3 (Cue3p) and similar proteins; Cue3p, also called coupling of ubiquitin conjugation to ER degradation protein 3, is encoded by the open reading frame (ORF) YGL110C. It is involved in the intramolecular monoubiquitination that serves as a regulatory signal in a variety of cellular processes in yeast. Cue3p contains a CUE domain. Pssm-ID: 270556 Cd Length: 41 Bit Score: 35.62 E-value: 2.55e-03
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| CUE | smart00546 | Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also ... |
155-194 | 7.87e-03 | ||
Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2. Ponting (Biochem. J.) "Proteins of the Endoplasmic reticulum" (in press) Pssm-ID: 214715 Cd Length: 43 Bit Score: 34.39 E-value: 7.87e-03
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