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Conserved domains on  [gi|1886621345|gb|KAF6426039|]
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zinc finger SWIM-type containing 8 [Molossus molossus]

Protein Classification

SWIM zinc finger domain-containing protein( domain architecture ID 10790860)

SWIM zinc finger domain-containing protein; SWIM domains are versatile and can interact with DNA or proteins in different contexts such as inhibiting DNA damage tolerance in yeast and protein-protein interactions in yeast and humans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SWIM COG4715
Uncharacterized protein, contains SWIM-type Zn finger domain [Function unknown];
116-257 1.25e-08

Uncharacterized protein, contains SWIM-type Zn finger domain [Function unknown];


:

Pssm-ID: 443750 [Multi-domain]  Cd Length: 508  Bit Score: 59.84  E-value: 1.25e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886621345  116 NEEDIRlysclANGSADEFQRGDQLFRMRAVKDPLQIGFHLSATVvppqmvppKG--AYNVAVMFDRCRVTSCSCTCGAG 193
Cdd:COG4715      7 TEDDIR-----RLAGPRIFERGREYAREGRVLDLDVEDGRLEATV--------QGseDYRVRVDLDDGGDLDSSCTCPYG 73

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1886621345  194 A-KWCTHVVALCLFRIHNASAV----CLRAPVSESLSRLQRDQLQKFAQYLISELPQqiLPTAQRLLDE 257
Cdd:COG4715     74 GgGFCKHVVAVLLALLDQPEEGaprqSEREALEELLERLSKEELVELLLELAAEDPE--LRELRRALDD 140
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1505-1650 7.70e-07

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 54.39  E-value: 7.70e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886621345 1505 PYTALQPHLPcSPQYLTHPAHPAHPMPHM------PRPAVFPVPS--SAYPQGVHPAFLG------------AQYPYSVT 1564
Cdd:pfam03154  358 PPTTPIPQLP-NPQSHKHPPHLSGPSPFQmnsnlpPPPALKPLSSlsTHHPPSAHPPPLQlmpqsqqlppppAQPPVLTQ 436

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886621345 1565 PPSLAATAVSFP-------VPSMAPITVHPYH-------TEP-GLPLPTSVALSSVHPASTFPAIQGASLPALTTQPSPL 1629
Cdd:pfam03154  437 SQSLPPPAASHPptsglhqVPSQSPFPQHPFVpggpppiTPPsGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPP 516

                          170       180
                   ....*....|....*....|...
gi 1886621345 1630 VSGGFPPPE--EETHSQPVNPHS 1650
Cdd:pfam03154  517 VQIKEEALDeaEEPESPPPPPRS 539
 
Name Accession Description Interval E-value
SWIM COG4715
Uncharacterized protein, contains SWIM-type Zn finger domain [Function unknown];
116-257 1.25e-08

Uncharacterized protein, contains SWIM-type Zn finger domain [Function unknown];


Pssm-ID: 443750 [Multi-domain]  Cd Length: 508  Bit Score: 59.84  E-value: 1.25e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886621345  116 NEEDIRlysclANGSADEFQRGDQLFRMRAVKDPLQIGFHLSATVvppqmvppKG--AYNVAVMFDRCRVTSCSCTCGAG 193
Cdd:COG4715      7 TEDDIR-----RLAGPRIFERGREYAREGRVLDLDVEDGRLEATV--------QGseDYRVRVDLDDGGDLDSSCTCPYG 73

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1886621345  194 A-KWCTHVVALCLFRIHNASAV----CLRAPVSESLSRLQRDQLQKFAQYLISELPQqiLPTAQRLLDE 257
Cdd:COG4715     74 GgGFCKHVVAVLLALLDQPEEGaprqSEREALEELLERLSKEELVELLLELAAEDPE--LRELRRALDD 140
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1505-1650 7.70e-07

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 54.39  E-value: 7.70e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886621345 1505 PYTALQPHLPcSPQYLTHPAHPAHPMPHM------PRPAVFPVPS--SAYPQGVHPAFLG------------AQYPYSVT 1564
Cdd:pfam03154  358 PPTTPIPQLP-NPQSHKHPPHLSGPSPFQmnsnlpPPPALKPLSSlsTHHPPSAHPPPLQlmpqsqqlppppAQPPVLTQ 436

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886621345 1565 PPSLAATAVSFP-------VPSMAPITVHPYH-------TEP-GLPLPTSVALSSVHPASTFPAIQGASLPALTTQPSPL 1629
Cdd:pfam03154  437 SQSLPPPAASHPptsglhqVPSQSPFPQHPFVpggpppiTPPsGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPP 516

                          170       180
                   ....*....|....*....|...
gi 1886621345 1630 VSGGFPPPE--EETHSQPVNPHS 1650
Cdd:pfam03154  517 VQIKEEALDeaEEPESPPPPPRS 539
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1500-1648 3.25e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 3.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886621345 1500 SPGLHPYTALQPHLPCSPQYLTHPAHPAHPMPHMPRPAVFPVPSSAypqgvhPAFLGAQYPYSVTPPSLAATAVSFPVPS 1579
Cdd:PHA03247  2770 APPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPA------AALPPAASPAGPLPPPTSAQPTAPPPPP 2843

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1886621345 1580 MAPITVHPY--HTEPGLPL---PTSVALSSVHPASTFPAIQGASLPALTTQPSPLvsgGFPPPEEETHSQPVNP 1648
Cdd:PHA03247  2844 GPPPPSLPLggSVAPGGDVrrrPPSRSPAAKPAAPARPPVRRLARPAVSRSTESF---ALPPDQPERPPQPQAP 2914
 
Name Accession Description Interval E-value
SWIM COG4715
Uncharacterized protein, contains SWIM-type Zn finger domain [Function unknown];
116-257 1.25e-08

Uncharacterized protein, contains SWIM-type Zn finger domain [Function unknown];


Pssm-ID: 443750 [Multi-domain]  Cd Length: 508  Bit Score: 59.84  E-value: 1.25e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886621345  116 NEEDIRlysclANGSADEFQRGDQLFRMRAVKDPLQIGFHLSATVvppqmvppKG--AYNVAVMFDRCRVTSCSCTCGAG 193
Cdd:COG4715      7 TEDDIR-----RLAGPRIFERGREYAREGRVLDLDVEDGRLEATV--------QGseDYRVRVDLDDGGDLDSSCTCPYG 73

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1886621345  194 A-KWCTHVVALCLFRIHNASAV----CLRAPVSESLSRLQRDQLQKFAQYLISELPQqiLPTAQRLLDE 257
Cdd:COG4715     74 GgGFCKHVVAVLLALLDQPEEGaprqSEREALEELLERLSKEELVELLLELAAEDPE--LRELRRALDD 140
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1505-1650 7.70e-07

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 54.39  E-value: 7.70e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886621345 1505 PYTALQPHLPcSPQYLTHPAHPAHPMPHM------PRPAVFPVPS--SAYPQGVHPAFLG------------AQYPYSVT 1564
Cdd:pfam03154  358 PPTTPIPQLP-NPQSHKHPPHLSGPSPFQmnsnlpPPPALKPLSSlsTHHPPSAHPPPLQlmpqsqqlppppAQPPVLTQ 436

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886621345 1565 PPSLAATAVSFP-------VPSMAPITVHPYH-------TEP-GLPLPTSVALSSVHPASTFPAIQGASLPALTTQPSPL 1629
Cdd:pfam03154  437 SQSLPPPAASHPptsglhqVPSQSPFPQHPFVpggpppiTPPsGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPP 516

                          170       180
                   ....*....|....*....|...
gi 1886621345 1630 VSGGFPPPE--EETHSQPVNPHS 1650
Cdd:pfam03154  517 VQIKEEALDeaEEPESPPPPPRS 539
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1500-1658 1.77e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 46.68  E-value: 1.77e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886621345 1500 SPGLHPYTALQPHLPCSPQYL-THPAHPAHPMPHMPRPAVFPVPSSAYPQGVHPAFLGAQYPYSVTPPSLAATAVSFPvP 1578
Cdd:pfam03154  262 SPQPLPQPSLHGQMPPMPHSLqTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQP-P 340

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886621345 1579 SMAPITVHPYHTEPGLPLPTSvalssvhPASTFPAIQGASLPALTTQPSPL-VSGGFPPPEEethSQPVNPHSLHHLHAA 1657
Cdd:pfam03154  341 REQPLPPAPLSMPHIKPPPTT-------PIPQLPNPQSHKHPPHLSGPSPFqMNSNLPPPPA---LKPLSSLSTHHPPSA 410


                   .
gi 1886621345 1658 Y 1658
Cdd:pfam03154  411 H 411
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1500-1648 3.25e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 3.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886621345 1500 SPGLHPYTALQPHLPCSPQYLTHPAHPAHPMPHMPRPAVFPVPSSAypqgvhPAFLGAQYPYSVTPPSLAATAVSFPVPS 1579
Cdd:PHA03247  2770 APPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPA------AALPPAASPAGPLPPPTSAQPTAPPPPP 2843

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1886621345 1580 MAPITVHPY--HTEPGLPL---PTSVALSSVHPASTFPAIQGASLPALTTQPSPLvsgGFPPPEEETHSQPVNP 1648
Cdd:PHA03247  2844 GPPPPSLPLggSVAPGGDVrrrPPSRSPAAKPAAPARPPVRRLARPAVSRSTESF---ALPPDQPERPPQPQAP 2914
PHA03377 PHA03377
EBNA-3C; Provisional
 1496-1645 3.60e-04

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 45.43  E-value: 3.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886621345 1496 GHGHSPGlhPYTALQPHLPcsPQYLTHPAH---------PAHPMPHMPRPAVFPVPssaypqgvhpaflgaQYPYSVTPP 1566
Cdd:PHA03377   818 GHGHPQG--PWAPRPPHLP--PQWDGSAGHgqdqvsqfpHLQSETGPPRLQLSQVP---------------QLPYSQTLV 878

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886621345 1567 SLAATAVSFPVPSmAPITVHPYH-TEPGLPLPTSVALSSVHPASTFPAI-------QGASLPALTTQPSPLvsggfPPPE 1638
Cdd:PHA03377   879 SSSAPSWSSPQPR-APIRPIPTRfPPPPMPLQDSMAVGCDSSGTACPSMpfasdysQGAFTPLDINAQTPK-----RPRV 952


                   ....*..
gi 1886621345 1639 EETHSQP 1645
Cdd:PHA03377   953 EESSHGP 959
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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