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Conserved domains on  [gi|1919811541|gb|KAF8314207|]
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cyclin-like protein [Clavulina sp. PMI_390]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
29-179 9.62e-55

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410228  Cd Length: 150  Bit Score: 176.63  E-value: 9.62e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919811541  29 EASTQHQHWRYSRR-TLDAERTNLNAAAVEAIRQAFEIEDPgsssSIEFLTPEEELLLVKLYISKIGQLCAHFRMPEAVE 107
Cdd:cd20524     1 HTSTQRKHWIFSSEeELAELRAEANEKAREKLKESLKEEDA----EPKFLTPEEELLLVRYYEKKLLEFCRAFKLPDSVL 76
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1919811541 108 ATACTYLRRFYLRNTVMDWHPKSVMLTAIFLASKTTNNPIPIDTYASRIP--KTTREDVLDLEFLVAQSLGFEF 179
Cdd:cd20524    77 ATALTYFKRFYLKNSVMEYHPKEIMLTCLYLACKVEEFNISIDQFVGNIKesEKTAEIILEYELLLLQGLNFHL 150
CYCLIN_CCNH_rpt2 cd20525
second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
182-297 2.06e-30

second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410229  Cd Length: 126  Bit Score: 112.39  E-value: 2.06e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919811541 182 WHPYRALWGIYLDIQTLPDLQNAFNdIHAAYMAAIATVRQARLTDVELLYTPSQIALACWHLAAPG---LAEQWARAKFE 258
Cdd:cd20525     1 HHPYRPLEGFLLDLKTRLPDLKAEN-LEKLYKEAREFLNRSLLTDAPLLYPPSQIALAALLLAASEagiDVEEYLSEKLP 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1919811541 259 --------EAVIPLLGEIKDAIAREGGVPDVERVRDIDKRLKICKNP 297
Cdd:cd20525    80 gseeseelEKLLEIIREIKKLVKKYEGPPDKEEVKALDKKLKKCRNP 126
 
Name Accession Description Interval E-value
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
29-179 9.62e-55

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410228  Cd Length: 150  Bit Score: 176.63  E-value: 9.62e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919811541  29 EASTQHQHWRYSRR-TLDAERTNLNAAAVEAIRQAFEIEDPgsssSIEFLTPEEELLLVKLYISKIGQLCAHFRMPEAVE 107
Cdd:cd20524     1 HTSTQRKHWIFSSEeELAELRAEANEKAREKLKESLKEEDA----EPKFLTPEEELLLVRYYEKKLLEFCRAFKLPDSVL 76
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1919811541 108 ATACTYLRRFYLRNTVMDWHPKSVMLTAIFLASKTTNNPIPIDTYASRIP--KTTREDVLDLEFLVAQSLGFEF 179
Cdd:cd20524    77 ATALTYFKRFYLKNSVMEYHPKEIMLTCLYLACKVEEFNISIDQFVGNIKesEKTAEIILEYELLLLQGLNFHL 150
ccl1 TIGR00569
cyclin ccl1; All proteins in this family for which functions are known are cyclins that are ...
28-310 1.09e-54

cyclin ccl1; All proteins in this family for which functions are known are cyclins that are components of TFIIH, a complex that is involved in nucleotide excision repair and transcription initiation. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, StanfordUniversity). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129660 [Multi-domain]  Cd Length: 305  Bit Score: 181.57  E-value: 1.09e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919811541  28 YEASTQHQHWRYSRR-TLDAERTNLNAAAVEAIRQafeiEDPGSSSSIEFLTPEEELLLVKLYISKIGQLCAHFR--MPE 104
Cdd:TIGR00569   1 YRNSSQKRHWTFTSEeQLQEKRADANAKFREAHEE----EEKVLEAKPIFLTPEEELDLVKYYEKRLLDFCSAFKptMPT 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919811541 105 AVEATACTYLRRFYLRNTVMDWHPKSVMLTAIFLASKTTNNPIPIDTYASRIPKT---TREDVLDLEFLVAQSLGFEFVV 181
Cdd:TIGR00569  77 SVVGTAIMYFKRFYLNNSVMEYHPKIIMLTCVFLACKVEEFNVSIDQFVGNLKETplkALEQVLEYELLLIQQLNFHLIV 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919811541 182 WHPYRALWGIYLDIQT-LPDLQNafndihAAYMAAIATVR--QARLTDVELLYTPSQIALACWHLAAPGLAEQWARAKFE 258
Cdd:TIGR00569 157 HNPYRPLEGFLIDIKTrLPGLEN------PEYLRKHADKFlnRTLLTDAYLLYTPSQIALAAILHTASRAGLNMESYLTE 230
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1919811541 259 EAVIP----LLGEIKDAIAREGGV------PDVERVRDIDKRLKICKNPEKVEGTKAYARKQ 310
Cdd:TIGR00569 231 QLSVPgnreELPQLIDIMRELRILvkkyeePRSEKVAALKKKLDECHSIEENLSSVKIRKRK 292
CYCLIN_CCNH_rpt2 cd20525
second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
182-297 2.06e-30

second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410229  Cd Length: 126  Bit Score: 112.39  E-value: 2.06e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919811541 182 WHPYRALWGIYLDIQTLPDLQNAFNdIHAAYMAAIATVRQARLTDVELLYTPSQIALACWHLAAPG---LAEQWARAKFE 258
Cdd:cd20525     1 HHPYRPLEGFLLDLKTRLPDLKAEN-LEKLYKEAREFLNRSLLTDAPLLYPPSQIALAALLLAASEagiDVEEYLSEKLP 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1919811541 259 --------EAVIPLLGEIKDAIAREGGVPDVERVRDIDKRLKICKNP 297
Cdd:cd20525    80 gseeseelEKLLEIIREIKKLVKKYEGPPDKEEVKALDKKLKKCRNP 126
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
71-265 2.89e-29

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 114.44  E-value: 2.89e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919811541  71 SSSIEFLTPEEELLLVKLYISKIGQLCAHFRMPEAVEATACTYLRRFYLRNTVMDWHPKSVMLTAIFLASKTTNNPIPID 150
Cdd:COG5333    30 LVLEPELTLEKELNLVIYYLKLIMDLCTRLNLPQTVLATAILFFSRFYLKNSVEEISLYSVVTTCVYLACKVEDTPRDIS 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919811541 151 T-------YASRIPKTTREDVLDLEFLVAQSLGFEFVVWHPYRALWGIYLDIQTL---PDLQNAFNDIHAAYmaaiatvr 220
Cdd:COG5333   110 IesfeardLWSEEPKSSRERILEYEFELLEALDFDLHVHHPYKYLEGFLKDLQEKdkyKLLQIAWKIINDAL-------- 181
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1919811541 221 qarLTDVELLYTPSQIALACWHLAAPGLA----EQWARAKFE--EAVIPLL 265
Cdd:COG5333   182 ---RTDLCLLYPPHIIALAALLIACEVLGmpiiKLLDFVSYEtkEEVIALN 229
Cyclin_C_2 pfam16899
Cyclin C-terminal domain; Cyclins contain two domains of similar all-alpha fold, this family ...
183-257 4.57e-23

Cyclin C-terminal domain; Cyclins contain two domains of similar all-alpha fold, this family corresponds with the C-terminal domain of some cyclins including cyclin C and cyclin H.


Pssm-ID: 465303  Cd Length: 98  Bit Score: 91.83  E-value: 4.57e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1919811541 183 HPYRALWGIYLDIQTLPDLQNafNDIHAAYMAAIATVRQARLTDVELLYTPSQIALACWHLAAPGLAEQWARAKF 257
Cdd:pfam16899   1 HPFRPLEGFLLDLKTRPPLLE--DRIESLYKRAREILKSALLTDAYFLYTPSQIALAALLLADSPLAEFYLTEKF 73
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
95-173 1.77e-12

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 62.22  E-value: 1.77e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1919811541   95 QLCAHFRMPEAVEATACTYLRRFYLRNTVMDWHPKSVMLTAIFLASKTTNNPIPIDTYASRIPKTTREDVLDLEFLVAQ 173
Cdd:smart00385   5 RVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGYFTEEEILRMERLLLE 83
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
95-178 4.82e-04

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 39.42  E-value: 4.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919811541  95 QLCAHFRMPEAVEATACTYLRRFYLRNTVMDWHPKSVMLTAIFLASKTTNNPIP-IDTYASRIPKT-TREDVLDLEFLVA 172
Cdd:pfam00134  40 EVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTCLFIAAKYEEIYPPtVEDLVYITDNAyTREEILRMERLIL 119

                  ....*.
gi 1919811541 173 QSLGFE 178
Cdd:pfam00134 120 ETLNFD 125
 
Name Accession Description Interval E-value
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
29-179 9.62e-55

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410228  Cd Length: 150  Bit Score: 176.63  E-value: 9.62e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919811541  29 EASTQHQHWRYSRR-TLDAERTNLNAAAVEAIRQAFEIEDPgsssSIEFLTPEEELLLVKLYISKIGQLCAHFRMPEAVE 107
Cdd:cd20524     1 HTSTQRKHWIFSSEeELAELRAEANEKAREKLKESLKEEDA----EPKFLTPEEELLLVRYYEKKLLEFCRAFKLPDSVL 76
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1919811541 108 ATACTYLRRFYLRNTVMDWHPKSVMLTAIFLASKTTNNPIPIDTYASRIP--KTTREDVLDLEFLVAQSLGFEF 179
Cdd:cd20524    77 ATALTYFKRFYLKNSVMEYHPKEIMLTCLYLACKVEEFNISIDQFVGNIKesEKTAEIILEYELLLLQGLNFHL 150
ccl1 TIGR00569
cyclin ccl1; All proteins in this family for which functions are known are cyclins that are ...
28-310 1.09e-54

cyclin ccl1; All proteins in this family for which functions are known are cyclins that are components of TFIIH, a complex that is involved in nucleotide excision repair and transcription initiation. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, StanfordUniversity). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129660 [Multi-domain]  Cd Length: 305  Bit Score: 181.57  E-value: 1.09e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919811541  28 YEASTQHQHWRYSRR-TLDAERTNLNAAAVEAIRQafeiEDPGSSSSIEFLTPEEELLLVKLYISKIGQLCAHFR--MPE 104
Cdd:TIGR00569   1 YRNSSQKRHWTFTSEeQLQEKRADANAKFREAHEE----EEKVLEAKPIFLTPEEELDLVKYYEKRLLDFCSAFKptMPT 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919811541 105 AVEATACTYLRRFYLRNTVMDWHPKSVMLTAIFLASKTTNNPIPIDTYASRIPKT---TREDVLDLEFLVAQSLGFEFVV 181
Cdd:TIGR00569  77 SVVGTAIMYFKRFYLNNSVMEYHPKIIMLTCVFLACKVEEFNVSIDQFVGNLKETplkALEQVLEYELLLIQQLNFHLIV 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919811541 182 WHPYRALWGIYLDIQT-LPDLQNafndihAAYMAAIATVR--QARLTDVELLYTPSQIALACWHLAAPGLAEQWARAKFE 258
Cdd:TIGR00569 157 HNPYRPLEGFLIDIKTrLPGLEN------PEYLRKHADKFlnRTLLTDAYLLYTPSQIALAAILHTASRAGLNMESYLTE 230
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1919811541 259 EAVIP----LLGEIKDAIAREGGV------PDVERVRDIDKRLKICKNPEKVEGTKAYARKQ 310
Cdd:TIGR00569 231 QLSVPgnreELPQLIDIMRELRILvkkyeePRSEKVAALKKKLDECHSIEENLSSVKIRKRK 292
CYCLIN_CCNH_rpt2 cd20525
second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
182-297 2.06e-30

second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410229  Cd Length: 126  Bit Score: 112.39  E-value: 2.06e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919811541 182 WHPYRALWGIYLDIQTLPDLQNAFNdIHAAYMAAIATVRQARLTDVELLYTPSQIALACWHLAAPG---LAEQWARAKFE 258
Cdd:cd20525     1 HHPYRPLEGFLLDLKTRLPDLKAEN-LEKLYKEAREFLNRSLLTDAPLLYPPSQIALAALLLAASEagiDVEEYLSEKLP 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1919811541 259 --------EAVIPLLGEIKDAIAREGGVPDVERVRDIDKRLKICKNP 297
Cdd:cd20525    80 gseeseelEKLLEIIREIKKLVKKYEGPPDKEEVKALDKKLKKCRNP 126
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
71-265 2.89e-29

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 114.44  E-value: 2.89e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919811541  71 SSSIEFLTPEEELLLVKLYISKIGQLCAHFRMPEAVEATACTYLRRFYLRNTVMDWHPKSVMLTAIFLASKTTNNPIPID 150
Cdd:COG5333    30 LVLEPELTLEKELNLVIYYLKLIMDLCTRLNLPQTVLATAILFFSRFYLKNSVEEISLYSVVTTCVYLACKVEDTPRDIS 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919811541 151 T-------YASRIPKTTREDVLDLEFLVAQSLGFEFVVWHPYRALWGIYLDIQTL---PDLQNAFNDIHAAYmaaiatvr 220
Cdd:COG5333   110 IesfeardLWSEEPKSSRERILEYEFELLEALDFDLHVHHPYKYLEGFLKDLQEKdkyKLLQIAWKIINDAL-------- 181
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1919811541 221 qarLTDVELLYTPSQIALACWHLAAPGLA----EQWARAKFE--EAVIPLL 265
Cdd:COG5333   182 ---RTDLCLLYPPHIIALAALLIACEVLGmpiiKLLDFVSYEtkEEVIALN 229
CYCLIN_AcCycH_rpt1 cd20585
first cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; CycH ...
28-178 1.18e-26

first cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; CycH associates with and activates the cyclin-dependent kinases, CDK-2 and CDK-3. CycH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410288  Cd Length: 170  Bit Score: 103.75  E-value: 1.18e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919811541  28 YEASTQHQHWRYSRRTLDAERTNLNAAAVEAIRQ----AFEIEDPGS--------------SSSIEFLTPEEELLLVKLY 89
Cdd:cd20585     2 FATSTHRQRWIFTPQDLTEKREAANQRAVDALQQcgatRVEAQAAGSlgggaevggsngkaAKLPEPLSADEELLMLKYY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919811541  90 ISKIGQLCAHFRMPEAVEATACTYLRRFYLRNTVMDWHPKSVMLTAIFLASKTTNNPIPidtyASRIPKTTRED---VLD 166
Cdd:cd20585    82 EQKIQEVCRALRLPNKIQATALLYFKRFYLQWSVMEHDPKRIMLTCIYLACKVEEYHVS----AEELGKGIQQDhqlILK 157
                         170
                  ....*....|..
gi 1919811541 167 LEFLVAQSLGFE 178
Cdd:cd20585   158 NELALLQGLNFD 169
Cyclin_C_2 pfam16899
Cyclin C-terminal domain; Cyclins contain two domains of similar all-alpha fold, this family ...
183-257 4.57e-23

Cyclin C-terminal domain; Cyclins contain two domains of similar all-alpha fold, this family corresponds with the C-terminal domain of some cyclins including cyclin C and cyclin H.


Pssm-ID: 465303  Cd Length: 98  Bit Score: 91.83  E-value: 4.57e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1919811541 183 HPYRALWGIYLDIQTLPDLQNafNDIHAAYMAAIATVRQARLTDVELLYTPSQIALACWHLAAPGLAEQWARAKF 257
Cdd:pfam16899   1 HPFRPLEGFLLDLKTRPPLLE--DRIESLYKRAREILKSALLTDAYFLYTPSQIALAALLLADSPLAEFYLTEKF 73
CYCLIN_AcCycH_rpt2 cd20586
second cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; ...
182-297 2.85e-13

second cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; CycH associates with and activates the cyclin-dependent kinases, CDK-2 and CDK-3. CycH contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410289 [Multi-domain]  Cd Length: 132  Bit Score: 65.91  E-value: 2.85e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919811541 182 WHPYRALWGIYLDIQT------LPDLQNafndIHAAYMAAIATVRQARLTDVELLYTPSQIALACWHLAAP--------- 246
Cdd:cd20586     1 YAPYRALEGFVQDLEEflaagsGPDSQG----LQELRKAALAAVDKLMLTDAPLLYPPGQLALAALRSANKakggvdfdr 76
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1919811541 247 ------GLAEQWARAKFEEAVIPLLGEIkDAIAREGGVPDVERVRDIDKRLKICKNP 297
Cdd:cd20586    77 ylervaARAASKMPDDPAAALTAVLDEI-EYLVSEGARPEVAEVKEIDRKLKECRAP 132
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
95-173 1.77e-12

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 62.22  E-value: 1.77e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1919811541   95 QLCAHFRMPEAVEATACTYLRRFYLRNTVMDWHPKSVMLTAIFLASKTTNNPIPIDTYASRIPKTTREDVLDLEFLVAQ 173
Cdd:smart00385   5 RVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGYFTEEEILRMERLLLE 83
CYCLIN_CCNC_rpt1 cd20513
first cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or ...
86-175 7.19e-12

first cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or SRB11, is a component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. It mediates stress-induced mitochondrial fission and apoptosis. CCNC contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410217 [Multi-domain]  Cd Length: 101  Bit Score: 61.07  E-value: 7.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919811541  86 VKLYISK-IGQLCAHFRMPEAVEATACTYLRRFYLRNTVMDWHPKSVMLTAIFLASKTTNNPIP---IDTYASRI----- 156
Cdd:cd20513     1 LHIFFANfIQALGERLKLRQRVIATAIVYFKRFYARNSFKDIDPRLVAPTCLYLASKVEECPSHarlIVAEAKVLktkfs 80
                          90       100
                  ....*....|....*....|.
gi 1919811541 157 --PKTTREDVLDLEFLVAQSL 175
Cdd:cd20513    81 yeFPYRVNDILECEFYLLEAL 101
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
90-168 9.13e-10

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 54.72  E-value: 9.13e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1919811541  90 ISKIGQLCAHFRMPEAVEATACTYLRRFYLRNTVMDWHPKSVMLTAIFLASKTTNNPIPIDTYASRIpKTTREDVLDLE 168
Cdd:cd00043     3 VDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELPRTLKEIAKVS-GVSEKELRKAE 80
CYCLIN_SpCG1C-like_rpt1 cd20545
first cyclin box found in Schizosaccharomyces pombe cyclin C homolog 1 (pch1) and similar ...
93-142 2.48e-08

first cyclin box found in Schizosaccharomyces pombe cyclin C homolog 1 (pch1) and similar proteins; Cyclin pch1 is essential for progression through the whole cell cycle. It is a homolog of cyclin T; it forms a heterodimer with its partner kinase, cyclin-dependent kinase 9 (CDK9), that can phosphorylate both the pol II C-terminal domain (CTD) and the CTD of transcription elongation factor Spt5. Yeast Cdk9/Pch1, with mRNA capping enzyme Pct1, may also form an elongation checkpoint for mRNA quality control. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410248 [Multi-domain]  Cd Length: 116  Bit Score: 51.66  E-value: 2.48e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1919811541  93 IGQLCAHFRMPEAVEATACTYLRRFYLRNTVMDWHPKSVMLTAIFLASKT 142
Cdd:cd20545    12 IIRVGSRLKLPQTTLFTAATYFHRFYMRNSLKKYHYYEIAATCLFLATKV 61
CYCLIN_AtCycC_rpt1 cd20571
first cyclin box found in Arabidopsis thaliana C-type cyclins (CycCs) and similar proteins; ...
81-177 2.06e-07

first cyclin box found in Arabidopsis thaliana C-type cyclins (CycCs) and similar proteins; Plant CycCs are the cognate cyclin partners of cyclin-dependent kinase CDK8. They may be involved in cell cycle control. CycCs contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410274 [Multi-domain]  Cd Length: 107  Bit Score: 48.70  E-value: 2.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919811541  81 EELLLVKLYISK-IGQLCAHFRMPEAVEATACTYLRRFYLRNTVMDWHPKSVMLTAIFLASKTTNNPIPIDT---YASRI 156
Cdd:cd20571     1 EDVKLIKIHMSNyIKKLAQHIKVRQRVVATAITYFRRVYTRKSFTEYDPRLVAPTCLYLASKAEESTVQAKLlvfYMKRL 80
                          90       100
                  ....*....|....*....|....*.
gi 1919811541 157 PKTTR-----EDVLDLEFLVAQSLGF 177
Cdd:cd20571    81 YADEYhryeiKDILEMEMKLLEALDY 106
CYCLIN_ScCTK2-like_rpt1 cd20547
first cyclin box found in Saccharomyces cerevisiae CTD kinase subunit 2 (ScCTK2) and similar ...
93-179 1.36e-06

first cyclin box found in Saccharomyces cerevisiae CTD kinase subunit 2 (ScCTK2) and similar proteins; CTK2, also called CTD kinase subunit beta, CTDK-I subunit beta, or CTD kinase 38 kDa subunit, is the cyclin subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. CTK2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410250 [Multi-domain]  Cd Length: 110  Bit Score: 46.57  E-value: 1.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919811541  93 IGQLCAHFRMPEAVEATACTYLRRFYLRNTVMDWHPKSVMLTAIFLASKTTNNP-----IPIDTYASRIPKTTRED---- 163
Cdd:cd20547     9 ISQLCKKLKFPRRTLGTAMLLYQRFHLFNPFTDSSNYEVALACLFLASKIEDTQkkskdILAASYNLRHPDKISVDdqml 88
                          90       100
                  ....*....|....*....|..
gi 1919811541 164 ------VLDLEFLVAQSLGFEF 179
Cdd:cd20547    89 eefrkaILGLERLLLETICFDF 110
CYCLIN_CCNT2_rpt1 cd20596
first cyclin box found in cyclin-T2 (CCNT2); CCNT2, also termed CycT2, is a regulatory subunit ...
109-178 1.94e-05

first cyclin box found in cyclin-T2 (CCNT2); CCNT2, also termed CycT2, is a regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II). CCNT2 contains two cyclin boxs. The model responds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410299 [Multi-domain]  Cd Length: 139  Bit Score: 43.88  E-value: 1.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919811541 109 TACTYLRRFYLRNTVMDWHPKSVMLTAIFLASKTTNNP------------------IPIDTYASRIPKTTREDVLdLEFL 170
Cdd:cd20596    53 TAIVYMHRFYMHHSFTKFHRNIISPTALFLAAKVEEQPrklehvikvahaclnplePQLDTKSDAYLQQAQELVI-LETI 131

                  ....*...
gi 1919811541 171 VAQSLGFE 178
Cdd:cd20596   132 MLQTLGFE 139
CYCLIN_CCNL_rpt1 cd20532
first cyclin box found in cyclin-L (CCNL) family; The CCNL family includes two cyclins, CCNL1 ...
75-177 2.68e-05

first cyclin box found in cyclin-L (CCNL) family; The CCNL family includes two cyclins, CCNL1 and CCNL2. CCNL1 is involved in the regulation of RNA polymerase II (pol II) transcription. It functions in association with cyclin-dependent kinases (CDKs). CCNL2 is a novel RNA polymerase II-associated cyclin involved in pre-mRNA splicing. It may induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410235 [Multi-domain]  Cd Length: 127  Bit Score: 43.32  E-value: 2.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919811541  75 EFLTPEEELLLVKL---YISKIGQLcahFRMPEAVEATACTYLRRFYLRNTVMDWHPKSVMLTAIFLASKTTNNP----- 146
Cdd:cd20532     1 DGIDEETEIDLRIYgceLIQDAGIL---LKLPQVVMATAQVLFHRFYYRKSLRKFDVKIVAMACLFLASKIEETPrrlrd 77
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1919811541 147 -------------------IPIDtYASRIPKTTREDVLDLEFLVAQSLGF 177
Cdd:cd20532    78 vinvfhrllqrrlgkpaevLPLD-IGSAEYEELKNDIIKAERRILKELGF 126
CYCLIN_CCNT1_rpt1 cd20595
first cyclin box found in cyclin-T1 (CCNT1); CCNT1, also termed CycT1, is a host factor ...
109-178 7.83e-05

first cyclin box found in cyclin-T1 (CCNT1); CCNT1, also termed CycT1, is a host factor essential for HIV-1 replication in CD4 T cells and macrophages. It is a regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). CCNT1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410298 [Multi-domain]  Cd Length: 138  Bit Score: 42.35  E-value: 7.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919811541 109 TACTYLRRFYLRNTVMDWHPKSVMLTAIFLASKTTNNPIPID-----TYASRIPKT----TR--------EDVLDLEFLV 171
Cdd:cd20595    52 TAIVYMHRFYMIQSFTQFHRNSVAPAALFLAAKVEEQPKKLEhvikvAHTCLHPQEslpdTRseaylqqvQDLVILESII 131

                  ....*..
gi 1919811541 172 AQSLGFE 178
Cdd:cd20595   132 LQTLGFE 138
CYCLIN_CCNK_rpt1 cd20530
first cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase ...
76-178 3.13e-04

first cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase II-associated C-type cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. It is a regulatory subunit of cyclin-dependent kinases that mediates the activation of these target kinases. It plays a role in transcriptional regulation by controlling the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). CCNK contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410233 [Multi-domain]  Cd Length: 115  Bit Score: 39.91  E-value: 3.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919811541  76 FLTPEEELLLVKLYISKIGQLCAHFRMPEAVEATACTYLRRFYLRNTVMDwHPKSVMLTA-IFLASKTTNNP-------- 146
Cdd:cd20530     1 GIDPETEARYRREGARFIQDVGTKLGLPYDTIATGIVYFHRFYMFHSFKD-FDRYVTAACcLFLAGKVEETPkkckdiik 79
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1919811541 147 ----IPIDTYASRIPKTTREDVLDLEFLVAQSLGFE 178
Cdd:cd20530    80 tarsLLNDKQFAQFGDDPKEEVMVLERILLQTIKFD 115
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
95-178 4.82e-04

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 39.42  E-value: 4.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919811541  95 QLCAHFRMPEAVEATACTYLRRFYLRNTVMDWHPKSVMLTAIFLASKTTNNPIP-IDTYASRIPKT-TREDVLDLEFLVA 172
Cdd:pfam00134  40 EVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTCLFIAAKYEEIYPPtVEDLVYITDNAyTREEILRMERLIL 119

                  ....*.
gi 1919811541 173 QSLGFE 178
Cdd:pfam00134 120 ETLNFD 125
CYCLIN_CCNM_CCNQ_rpt1 cd20534
first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ...
96-147 8.22e-04

first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ancient conserved domain proteins (ACDPs), are evolutionarily conserved Mg2+ transporters. CCNM, also called cyclin-Q (CCNQ), or CDK10-activating cyclin, or cyclin-related protein FAM58A, associates with CDK10 to promote its kinase activity. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410237 [Multi-domain]  Cd Length: 110  Bit Score: 38.69  E-value: 8.22e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1919811541  96 LCAHFRMPEAVEATACTYLRRFYLRNTVMDWHPKSVMLTAIFLASKTTNNPI 147
Cdd:cd20534    12 AGLKLELSSVTIATACVLYHRFYRELSLEDYDPYLVAMACLYLAGKAEEQPR 63
CYCLIN_CCNC_rpt2 cd20514
second cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or ...
183-245 3.38e-03

second cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or SRB11, is a component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. It mediates stress-induced mitochondrial fission and apoptosis. CCNC contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410218 [Multi-domain]  Cd Length: 92  Bit Score: 36.44  E-value: 3.38e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919811541 183 HPYRALwgiyldIQTLPD-------LQNAFNDIHAAYMaaiatvrqarlTDVELLYTPSQIALACWHLAA 245
Cdd:cd20514     1 HPYRPL------TQYVQDaglddelLPLAWRIVNDSYR-----------TDVCLLYPPYLIALACLHMAC 53
CYCLIN_AcCycT_rpt1 cd20587
first cyclin box found in Arabidopsis thaliana T-type cyclins (CycTs) and similar proteins; ...
81-178 5.44e-03

first cyclin box found in Arabidopsis thaliana T-type cyclins (CycTs) and similar proteins; CycTs associate with their partner cyclin-dependent kinases (CDKs) to trigger their kinase activity. CycTs show high sequence similarity with metazoan cyclin-K (CCNK). CycTs contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410290 [Multi-domain]  Cd Length: 124  Bit Score: 36.73  E-value: 5.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919811541  81 EELLLVKLYISKIGQLCAHFRMPEAVEATACTYLRRFYLRNTVMDWHPKSVMLTAIFLASKTTNNPIPID---------- 150
Cdd:cd20587     7 KETYLRKSYCTFLQDLGMRLKVPQVTIATAIVFCHRFFLRQSHAKNDRQTIATVCMFLAGKVEETPRPLKdvivvsyeii 86
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1919811541 151 -----TYASRIPKTT-----REDVLDLEFLVAQSLGFE 178
Cdd:cd20587    87 fkkdpSAAQRIKQKEvyeqqKELVLNGEKLVLSTLGFD 124
CYCLIN_AcCycL_rpt1 cd20591
first cyclin box found in Arabidopsis thaliana L-type cyclins (CycL) and similar proteins; ...
101-178 6.46e-03

first cyclin box found in Arabidopsis thaliana L-type cyclins (CycL) and similar proteins; Cyclin-L1-1 (CycL1), also called arginine-rich cyclin 1 (AtRCY1), or protein MODIFIER OF SNC1 12, is the cognate cyclin for cyclin-dependent kinase G1 (CDKG1). It is involved in regulation of DNA methylation and transcriptional silencing. It is required for synapsis and male meiosis, and for the proper splicing of specific resistance (R) genes. L-type cyclins contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410294 [Multi-domain]  Cd Length: 128  Bit Score: 36.35  E-value: 6.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919811541 101 RMPEAVEATACTYLRRFYLRNTVMDWHPKSVMLTAIFLASKTTNNPIPIDTYA---SRIPKttREDVLDLEFLVAQSLGF 177
Cdd:cd20591    30 KLPQAVMATGQVLFQRFYCKKSFARFNVKRVAASCVWLAAKLEESPRKIRQVLmvfHRMEC--RRENLPLEPLEPESKKY 107

                  .
gi 1919811541 178 E 178
Cdd:cd20591   108 D 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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