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Conserved domains on  [gi|2051959599|gb|KAG6911852|]
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hypothetical protein DXG01_000099 [Tephrocybe rancida]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 18-168 8.01e-54

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410228  Cd Length: 150  Bit Score: 173.94  E-value: 8.01e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051959599  18 ESSTQFKNWRF-SPEHLSNLRSSLNAAAVDVIRNTLESEKPGSSsvvsFLTADEELLLVKLYISKITQLCGHFRFPEEVE 96
Cdd:cd20524     1 HTSTQRKHWIFsSEEELAELRAEANEKAREKLKESLKEEDAEPK----FLTPEEELLLVRYYEKKLLEFCRAFKLPDSVL 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2051959599  97 ATAISYLKRFYLKNTVMDWHPKNVMLTALFLATKTTNNPISLETYTTHIP--RTAPSDVLDLEFLVAQSLGFEF 168
Cdd:cd20524    77 ATALTYFKRFYLKNSVMEYHPKEIMLTCLYLACKVEEFNISIDQFVGNIKesEKTAEIILEYELLLLQGLNFHL 150
CYCLIN_CCNH_rpt2 cd20525
second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 171-293 7.77e-29

second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410229  Cd Length: 126  Bit Score: 108.15  E-value: 7.77e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051959599 171 WHAHRALWGIILDIQNLPDSPL--DTKLLYESAMAHIRASRLTDSELIYTPSQIALAALSLTAPN---LASQWSDSKLER 245
Cdd:cd20525     1 HHPYRPLEGFLLDLKTRLPDLKaeNLEKLYKEAREFLNRSLLTDAPLLYPPSQIALAALLLAASEagiDVEEYLSEKLPG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2051959599 246 ASASLALTAntLPTLLDSVKTVISSCGHPPDLEAVREVDRRLKLCKNP 293
Cdd:cd20525    81 SEESEELEK--LLEIIREIKKLVKKYEGPPDKEEVKALDKKLKKCRNP 126
 
Name Accession Description Interval E-value
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 18-168 8.01e-54

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410228  Cd Length: 150  Bit Score: 173.94  E-value: 8.01e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051959599  18 ESSTQFKNWRF-SPEHLSNLRSSLNAAAVDVIRNTLESEKPGSSsvvsFLTADEELLLVKLYISKITQLCGHFRFPEEVE 96
Cdd:cd20524     1 HTSTQRKHWIFsSEEELAELRAEANEKAREKLKESLKEEDAEPK----FLTPEEELLLVRYYEKKLLEFCRAFKLPDSVL 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2051959599  97 ATAISYLKRFYLKNTVMDWHPKNVMLTALFLATKTTNNPISLETYTTHIP--RTAPSDVLDLEFLVAQSLGFEF 168
Cdd:cd20524    77 ATALTYFKRFYLKNSVMEYHPKEIMLTCLYLACKVEEFNISIDQFVGNIKesEKTAEIILEYELLLLQGLNFHL 150
ccl1 TIGR00569
cyclin ccl1; All proteins in this family for which functions are known are cyclins that are ...
 17-294 9.53e-54

cyclin ccl1; All proteins in this family for which functions are known are cyclins that are components of TFIIH, a complex that is involved in nucleotide excision repair and transcription initiation. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, StanfordUniversity). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129660 [Multi-domain]  Cd Length: 305  Bit Score: 178.87  E-value: 9.53e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051959599  17 YESSTQFKNWRFSPE-HLSNLRSSLNAAAVDVIRNT---LESEKPgsssvvsFLTADEELLLVKLYISKITQLCGHFR-- 90
Cdd:TIGR00569   1 YRNSSQKRHWTFTSEeQLQEKRADANAKFREAHEEEekvLEAKPI-------FLTPEEELDLVKYYEKRLLDFCSAFKpt 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051959599  91 FPEEVEATAISYLKRFYLKNTVMDWHPKNVMLTALFLATKTTNNPISLETYTTHIPRT---APSDVLDLEFLVAQSLGFE 167
Cdd:TIGR00569  74 MPTSVVGTAIMYFKRFYLNNSVMEYHPKIIMLTCVFLACKVEEFNVSIDQFVGNLKETplkALEQVLEYELLLIQQLNFH 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051959599 168 FAIWHAHRALWGIILDIQNLPDSPLDTKLLYESAMAHIRASRLTDSELIYTPSQIALAALSLTAP----NLASQWSDSKl 243
Cdd:TIGR00569 154 LIVHNPYRPLEGFLIDIKTRLPGLENPEYLRKHADKFLNRTLLTDAYLLYTPSQIALAAILHTASraglNMESYLTEQL- 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2051959599 244 erasaSLALTANTLPTLLDSVKTV--ISSCGHPPDLEAVREVDRRLKLCKNPE 294
Cdd:TIGR00569 233 -----SVPGNREELPQLIDIMRELriLVKKYEEPRSEKVAALKKKLDECHSIE 280
CYCLIN_CCNH_rpt2 cd20525
second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 171-293 7.77e-29

second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410229  Cd Length: 126  Bit Score: 108.15  E-value: 7.77e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051959599 171 WHAHRALWGIILDIQNLPDSPL--DTKLLYESAMAHIRASRLTDSELIYTPSQIALAALSLTAPN---LASQWSDSKLER 245
Cdd:cd20525     1 HHPYRPLEGFLLDLKTRLPDLKaeNLEKLYKEAREFLNRSLLTDAPLLYPPSQIALAALLLAASEagiDVEEYLSEKLPG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2051959599 246 ASASLALTAntLPTLLDSVKTVISSCGHPPDLEAVREVDRRLKLCKNP 293
Cdd:cd20525    81 SEESEELEK--LLEIIREIKKLVKKYEGPPDKEEVKALDKKLKKCRNP 126
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 66-244 1.03e-25

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 104.43  E-value: 1.03e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051959599  66 LTADEELLLVKLYISKITQLCGHFRFPEEVEATAISYLKRFYLKNTVMDWHPKNVMLTALFLATKTTNNP--ISLETY-- 141
Cdd:COG5333    36 LTLEKELNLVIYYLKLIMDLCTRLNLPQTVLATAILFFSRFYLKNSVEEISLYSVVTTCVYLACKVEDTPrdISIESFea 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051959599 142 ---TTHIPRTAPSDVLDLEFLVAQSLGFEFAIWHAHRALWGIILDIQNlpdspLDTKLLYESAMAHIRASRLTDSELIYT 218
Cdd:COG5333   116 rdlWSEEPKSSRERILEYEFELLEALDFDLHVHHPYKYLEGFLKDLQE-----KDKYKLLQIAWKIINDALRTDLCLLYP 190

                         170       180
                  ....*....|....*....|....*..
gi 2051959599 219 PSQIALAALSLTAPNLASQ-WSDSKLE 244
Cdd:COG5333   191 PHIIALAALLIACEVLGMPiIKLLDFV 217
Cyclin_C_2 pfam16899
Cyclin C-terminal domain; Cyclins contain two domains of similar all-alpha fold, this family ...
 172-271 4.06e-21

Cyclin C-terminal domain; Cyclins contain two domains of similar all-alpha fold, this family corresponds with the C-terminal domain of some cyclins including cyclin C and cyclin H.


Pssm-ID: 465303  Cd Length: 98  Bit Score: 86.44  E-value: 4.06e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051959599 172 HAHRALWGIILDIQNLPDSPLDT-KLLYESAMAHIRASRLTDSELIYTPSQIALAALSLTAPNLASQWSDSKLERASASl 250
Cdd:pfam16899   1 HPFRPLEGFLLDLKTRPPLLEDRiESLYKRAREILKSALLTDAYFLYTPSQIALAALLLADSPLAEFYLTEKFGLPEDR- 79

                          90       100
                  ....*....|....*....|.
gi 2051959599 251 altantlPTLLDSVKTVISSC 271
Cdd:pfam16899  80 -------ETKLEKLLDTIESC 93
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 82-162 4.43e-12

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 61.07  E-value: 4.43e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051959599   82 ITQLCGHFRFPEEVEATAISYLKRFYLKNTVMDWHPKNVMLTALFLATKTTNNPISLETYTTHIPRTAPSDVLDLEFLVA 161
Cdd:smart00385   3 LRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGYFTEEEILRMERLLL 82


                   .
gi 2051959599  162 Q 162
Cdd:smart00385  83 E 83
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 82-167 3.25e-04

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 40.19  E-value: 3.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051959599  82 ITQLCGHFRFPEEVEATAISYLKRFYLKNTVMDWHPKNVMLTALFLATKTTN-NPISLE--------TYTthiprtaPSD 152
Cdd:pfam00134  38 LVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTCLFIAAKYEEiYPPTVEdlvyitdnAYT-------REE 110

                          90
                  ....*....|....*
gi 2051959599 153 VLDLEFLVAQSLGFE 167
Cdd:pfam00134 111 ILRMERLILETLNFD 125
 
Name Accession Description Interval E-value
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 18-168 8.01e-54

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410228  Cd Length: 150  Bit Score: 173.94  E-value: 8.01e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051959599  18 ESSTQFKNWRF-SPEHLSNLRSSLNAAAVDVIRNTLESEKPGSSsvvsFLTADEELLLVKLYISKITQLCGHFRFPEEVE 96
Cdd:cd20524     1 HTSTQRKHWIFsSEEELAELRAEANEKAREKLKESLKEEDAEPK----FLTPEEELLLVRYYEKKLLEFCRAFKLPDSVL 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2051959599  97 ATAISYLKRFYLKNTVMDWHPKNVMLTALFLATKTTNNPISLETYTTHIP--RTAPSDVLDLEFLVAQSLGFEF 168
Cdd:cd20524    77 ATALTYFKRFYLKNSVMEYHPKEIMLTCLYLACKVEEFNISIDQFVGNIKesEKTAEIILEYELLLLQGLNFHL 150
ccl1 TIGR00569
cyclin ccl1; All proteins in this family for which functions are known are cyclins that are ...
 17-294 9.53e-54

cyclin ccl1; All proteins in this family for which functions are known are cyclins that are components of TFIIH, a complex that is involved in nucleotide excision repair and transcription initiation. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, StanfordUniversity). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129660 [Multi-domain]  Cd Length: 305  Bit Score: 178.87  E-value: 9.53e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051959599  17 YESSTQFKNWRFSPE-HLSNLRSSLNAAAVDVIRNT---LESEKPgsssvvsFLTADEELLLVKLYISKITQLCGHFR-- 90
Cdd:TIGR00569   1 YRNSSQKRHWTFTSEeQLQEKRADANAKFREAHEEEekvLEAKPI-------FLTPEEELDLVKYYEKRLLDFCSAFKpt 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051959599  91 FPEEVEATAISYLKRFYLKNTVMDWHPKNVMLTALFLATKTTNNPISLETYTTHIPRT---APSDVLDLEFLVAQSLGFE 167
Cdd:TIGR00569  74 MPTSVVGTAIMYFKRFYLNNSVMEYHPKIIMLTCVFLACKVEEFNVSIDQFVGNLKETplkALEQVLEYELLLIQQLNFH 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051959599 168 FAIWHAHRALWGIILDIQNLPDSPLDTKLLYESAMAHIRASRLTDSELIYTPSQIALAALSLTAP----NLASQWSDSKl 243
Cdd:TIGR00569 154 LIVHNPYRPLEGFLIDIKTRLPGLENPEYLRKHADKFLNRTLLTDAYLLYTPSQIALAAILHTASraglNMESYLTEQL- 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2051959599 244 erasaSLALTANTLPTLLDSVKTV--ISSCGHPPDLEAVREVDRRLKLCKNPE 294
Cdd:TIGR00569 233 -----SVPGNREELPQLIDIMRELriLVKKYEEPRSEKVAALKKKLDECHSIE 280
CYCLIN_AcCycH_rpt1 cd20585
first cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; CycH ...
 17-167 1.92e-30

first cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; CycH associates with and activates the cyclin-dependent kinases, CDK-2 and CDK-3. CycH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410288  Cd Length: 170  Bit Score: 113.77  E-value: 1.92e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051959599  17 YESSTQFKNWRFSPEHLSNLRSSLNAAAVDVIRN--------------TLESEKPGSSSVVSF----LTADEELLLVKLY 78
Cdd:cd20585     2 FATSTHRQRWIFTPQDLTEKREAANQRAVDALQQcgatrveaqaagslGGGAEVGGSNGKAAKlpepLSADEELLMLKYY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051959599  79 ISKITQLCGHFRFPEEVEATAISYLKRFYLKNTVMDWHPKNVMLTALFLATKTTNNPISLETYTTHIPRTaPSDVLDLEF 158
Cdd:cd20585    82 EQKIQEVCRALRLPNKIQATALLYFKRFYLQWSVMEHDPKRIMLTCIYLACKVEEYHVSAEELGKGIQQD-HQLILKNEL 160


                  ....*....
gi 2051959599 159 LVAQSLGFE 167
Cdd:cd20585   161 ALLQGLNFD 169
CYCLIN_CCNH_rpt2 cd20525
second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 171-293 7.77e-29

second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410229  Cd Length: 126  Bit Score: 108.15  E-value: 7.77e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051959599 171 WHAHRALWGIILDIQNLPDSPL--DTKLLYESAMAHIRASRLTDSELIYTPSQIALAALSLTAPN---LASQWSDSKLER 245
Cdd:cd20525     1 HHPYRPLEGFLLDLKTRLPDLKaeNLEKLYKEAREFLNRSLLTDAPLLYPPSQIALAALLLAASEagiDVEEYLSEKLPG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2051959599 246 ASASLALTAntLPTLLDSVKTVISSCGHPPDLEAVREVDRRLKLCKNP 293
Cdd:cd20525    81 SEESEELEK--LLEIIREIKKLVKKYEGPPDKEEVKALDKKLKKCRNP 126
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 66-244 1.03e-25

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 104.43  E-value: 1.03e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051959599  66 LTADEELLLVKLYISKITQLCGHFRFPEEVEATAISYLKRFYLKNTVMDWHPKNVMLTALFLATKTTNNP--ISLETY-- 141
Cdd:COG5333    36 LTLEKELNLVIYYLKLIMDLCTRLNLPQTVLATAILFFSRFYLKNSVEEISLYSVVTTCVYLACKVEDTPrdISIESFea 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051959599 142 ---TTHIPRTAPSDVLDLEFLVAQSLGFEFAIWHAHRALWGIILDIQNlpdspLDTKLLYESAMAHIRASRLTDSELIYT 218
Cdd:COG5333   116 rdlWSEEPKSSRERILEYEFELLEALDFDLHVHHPYKYLEGFLKDLQE-----KDKYKLLQIAWKIINDALRTDLCLLYP 190

                         170       180
                  ....*....|....*....|....*..
gi 2051959599 219 PSQIALAALSLTAPNLASQ-WSDSKLE 244
Cdd:COG5333   191 PHIIALAALLIACEVLGMPiIKLLDFV 217
Cyclin_C_2 pfam16899
Cyclin C-terminal domain; Cyclins contain two domains of similar all-alpha fold, this family ...
 172-271 4.06e-21

Cyclin C-terminal domain; Cyclins contain two domains of similar all-alpha fold, this family corresponds with the C-terminal domain of some cyclins including cyclin C and cyclin H.


Pssm-ID: 465303  Cd Length: 98  Bit Score: 86.44  E-value: 4.06e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051959599 172 HAHRALWGIILDIQNLPDSPLDT-KLLYESAMAHIRASRLTDSELIYTPSQIALAALSLTAPNLASQWSDSKLERASASl 250
Cdd:pfam16899   1 HPFRPLEGFLLDLKTRPPLLEDRiESLYKRAREILKSALLTDAYFLYTPSQIALAALLLADSPLAEFYLTEKFGLPEDR- 79

                          90       100
                  ....*....|....*....|.
gi 2051959599 251 altantlPTLLDSVKTVISSC 271
Cdd:pfam16899  80 -------ETKLEKLLDTIESC 93
CYCLIN_AcCycH_rpt2 cd20586
second cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; ...
 171-293 7.01e-13

second cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; CycH associates with and activates the cyclin-dependent kinases, CDK-2 and CDK-3. CycH contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410289 [Multi-domain]  Cd Length: 132  Bit Score: 65.14  E-value: 7.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051959599 171 WHAHRALWGIILDIQ------NLPDSP-LDTklLYESAMAHIRASRLTDSELIYTPSQIALAALSLTAPNLASQWSDSKL 243
Cdd:cd20586     1 YAPYRALEGFVQDLEeflaagSGPDSQgLQE--LRKAALAAVDKLMLTDAPLLYPPGQLALAALRSANKAKGGVDFDRYL 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2051959599 244 ER-----ASASLALTANTLPTLLDSVKTVISScGHPPDLEAVREVDRRLKLCKNP 293
Cdd:cd20586    79 ERvaaraASKMPDDPAAALTAVLDEIEYLVSE-GARPEVAEVKEIDRKLKECRAP 132
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 82-162 4.43e-12

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 61.07  E-value: 4.43e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051959599   82 ITQLCGHFRFPEEVEATAISYLKRFYLKNTVMDWHPKNVMLTALFLATKTTNNPISLETYTTHIPRTAPSDVLDLEFLVA 161
Cdd:smart00385   3 LRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGYFTEEEILRMERLLL 82


                   .
gi 2051959599  162 Q 162
Cdd:smart00385  83 E 83
CYCLIN_CCNC_rpt1 cd20513
first cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or ...
 75-164 2.88e-11

first cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or SRB11, is a component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. It mediates stress-induced mitochondrial fission and apoptosis. CCNC contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410217 [Multi-domain]  Cd Length: 101  Bit Score: 59.53  E-value: 2.88e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051959599  75 VKLYISK-ITQLCGHFRFPEEVEATAISYLKRFYLKNTVMDWHPKNVMLTALFLATKTTNNPI---SLETYTTHIPRTA- 149
Cdd:cd20513     1 LHIFFANfIQALGERLKLRQRVIATAIVYFKRFYARNSFKDIDPRLVAPTCLYLASKVEECPSharLIVAEAKVLKTKFs 80

                          90       100
                  ....*....|....*....|.
gi 2051959599 150 ------PSDVLDLEFLVAQSL 164
Cdd:cd20513    81 yefpyrVNDILECEFYLLEAL 101
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 79-157 3.82e-09

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 52.80  E-value: 3.82e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2051959599  79 ISKITQLCGHFRFPEEVEATAISYLKRFYLKNTVMDWHPKNVMLTALFLATKTTNNPISLETYTTHIpRTAPSDVLDLE 157
Cdd:cd00043     3 VDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELPRTLKEIAKVS-GVSEKELRKAE 80
CYCLIN_ScCTK2-like_rpt1 cd20547
first cyclin box found in Saccharomyces cerevisiae CTD kinase subunit 2 (ScCTK2) and similar ...
 82-168 5.38e-08

first cyclin box found in Saccharomyces cerevisiae CTD kinase subunit 2 (ScCTK2) and similar proteins; CTK2, also called CTD kinase subunit beta, CTDK-I subunit beta, or CTD kinase 38 kDa subunit, is the cyclin subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. CTK2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410250 [Multi-domain]  Cd Length: 110  Bit Score: 50.42  E-value: 5.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051959599  82 ITQLCGHFRFPEEVEATAISYLKRFYLKNTVMDWHPKNVMLTALFLATKTTN------------------NPISLETYTT 143
Cdd:cd20547     9 ISQLCKKLKFPRRTLGTAMLLYQRFHLFNPFTDSSNYEVALACLFLASKIEDtqkkskdilaasynlrhpDKISVDDQML 88

                          90       100
                  ....*....|....*....|....*
gi 2051959599 144 HIPRTApsdVLDLEFLVAQSLGFEF 168
Cdd:cd20547    89 EEFRKA---ILGLERLLLETICFDF 110
CYCLIN_AtCycC_rpt1 cd20571
first cyclin box found in Arabidopsis thaliana C-type cyclins (CycCs) and similar proteins; ...
 70-166 2.18e-07

first cyclin box found in Arabidopsis thaliana C-type cyclins (CycCs) and similar proteins; Plant CycCs are the cognate cyclin partners of cyclin-dependent kinase CDK8. They may be involved in cell cycle control. CycCs contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410274 [Multi-domain]  Cd Length: 107  Bit Score: 48.70  E-value: 2.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051959599  70 EELLLVKLYISK-ITQLCGHFRFPEEVEATAISYLKRFYLKNTVMDWHPKNVMLTALFLATKTTNNPISLETYTTHIPRT 148
Cdd:cd20571     1 EDVKLIKIHMSNyIKKLAQHIKVRQRVVATAITYFRRVYTRKSFTEYDPRLVAPTCLYLASKAEESTVQAKLLVFYMKRL 80

                          90       100
                  ....*....|....*....|....*.
gi 2051959599 149 APS--------DVLDLEFLVAQSLGF 166
Cdd:cd20571    81 YADeyhryeikDILEMEMKLLEALDY 106
CYCLIN_SpCG1C-like_rpt1 cd20545
first cyclin box found in Schizosaccharomyces pombe cyclin C homolog 1 (pch1) and similar ...
 82-131 5.44e-07

first cyclin box found in Schizosaccharomyces pombe cyclin C homolog 1 (pch1) and similar proteins; Cyclin pch1 is essential for progression through the whole cell cycle. It is a homolog of cyclin T; it forms a heterodimer with its partner kinase, cyclin-dependent kinase 9 (CDK9), that can phosphorylate both the pol II C-terminal domain (CTD) and the CTD of transcription elongation factor Spt5. Yeast Cdk9/Pch1, with mRNA capping enzyme Pct1, may also form an elongation checkpoint for mRNA quality control. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410248 [Multi-domain]  Cd Length: 116  Bit Score: 47.80  E-value: 5.44e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2051959599  82 ITQLCGHFRFPEEVEATAISYLKRFYLKNTVMDWHPKNVMLTALFLATKT 131
Cdd:cd20545    12 IIRVGSRLKLPQTTLFTAATYFHRFYMRNSLKKYHYYEIAATCLFLATKV 61
CYCLIN_CCNT1_rpt1 cd20595
first cyclin box found in cyclin-T1 (CCNT1); CCNT1, also termed CycT1, is a host factor ...
 98-167 6.82e-06

first cyclin box found in cyclin-T1 (CCNT1); CCNT1, also termed CycT1, is a host factor essential for HIV-1 replication in CD4 T cells and macrophages. It is a regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). CCNT1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410298 [Multi-domain]  Cd Length: 138  Bit Score: 45.05  E-value: 6.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051959599  98 TAISYLKRFYLKNTVMDWHPKNVMLTALFLATKTTNNPISLE-----TYTTHIPRTA------------PSDVLDLEFLV 160
Cdd:cd20595    52 TAIVYMHRFYMIQSFTQFHRNSVAPAALFLAAKVEEQPKKLEhvikvAHTCLHPQESlpdtrseaylqqVQDLVILESII 131


                  ....*..
gi 2051959599 161 AQSLGFE 167
Cdd:cd20595   132 LQTLGFE 138
CYCLIN_CCNT2_rpt1 cd20596
first cyclin box found in cyclin-T2 (CCNT2); CCNT2, also termed CycT2, is a regulatory subunit ...
 98-167 1.52e-05

first cyclin box found in cyclin-T2 (CCNT2); CCNT2, also termed CycT2, is a regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II). CCNT2 contains two cyclin boxs. The model responds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410299 [Multi-domain]  Cd Length: 139  Bit Score: 44.27  E-value: 1.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051959599  98 TAISYLKRFYLKNTVMDWHPKNVMLTALFLATKTTNNPISLE-----TYTTHIPRTAPSD------------VLDLEFLV 160
Cdd:cd20596    53 TAIVYMHRFYMHHSFTKFHRNIISPTALFLAAKVEEQPRKLEhvikvAHACLNPLEPQLDtksdaylqqaqeLVILETIM 132


                  ....*..
gi 2051959599 161 AQSLGFE 167
Cdd:cd20596   133 LQTLGFE 139
CYCLIN_CCNT_rpt1 cd20538
first cyclin box found in cyclin-T (CCNT) family; The CCNT family includes two C-type cyclins, ...
 81-167 1.14e-04

first cyclin box found in cyclin-T (CCNT) family; The CCNT family includes two C-type cyclins, cyclin-T1 (CCNT1) and cyclin-T2 (CCNT2), both of which are regulatory subunits of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410241 [Multi-domain]  Cd Length: 137  Bit Score: 41.61  E-value: 1.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051959599  81 KITQLCGHfrfpeeveaTAISYLKRFYLKNTVMDWHPKNVMLTALFLATKTTNNPISLE--TYTTH--IPRTAPS----- 151
Cdd:cd20538    43 QVSQLCIN---------TAIVYMHRFYMFHSFTKFHRNSIAAAALFLAAKVEEQPRKLEhvIKVAHacLHRGEPDldtks 113

                          90       100
                  ....*....|....*....|....
gi 2051959599 152 --------DVLDLEFLVAQSLGFE 167
Cdd:cd20538   114 eaylqqaqELVINENILLQTLGFE 137
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 82-167 3.25e-04

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 40.19  E-value: 3.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051959599  82 ITQLCGHFRFPEEVEATAISYLKRFYLKNTVMDWHPKNVMLTALFLATKTTN-NPISLE--------TYTthiprtaPSD 152
Cdd:pfam00134  38 LVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTCLFIAAKYEEiYPPTVEdlvyitdnAYT-------REE 110

                          90
                  ....*....|....*
gi 2051959599 153 VLDLEFLVAQSLGFE 167
Cdd:pfam00134 111 ILRMERLILETLNFD 125
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 47-164 6.63e-04

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 39.58  E-value: 6.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051959599  47 VIRNTLESEKPGSSSVVSFLTADEELL--LVKLYISKITQLCGHFRFPEEVEATAISYLKRFYLKNTVMDWHPKNVMLTA 124
Cdd:cd20573    25 VLQTMLKAEETCLPSVSYFKCVQKEILpsMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSVEPTKKSRLQLLGATC 104

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2051959599 125 LFLATKTTNN-PISLET---YTTHIPRtaPSDVLDLEFLVAQSL 164
Cdd:cd20573   105 MFLASKMKETiPLTAEKlciYTDNSIR--PEELLQMELLVLNKL 146
CYCLIN_CCNK_rpt1 cd20530
first cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase ...
 65-167 2.90e-03

first cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase II-associated C-type cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. It is a regulatory subunit of cyclin-dependent kinases that mediates the activation of these target kinases. It plays a role in transcriptional regulation by controlling the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). CCNK contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410233 [Multi-domain]  Cd Length: 115  Bit Score: 37.21  E-value: 2.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051959599  65 FLTADEELLLVKLYISKITQLCGHFRFPEEVEATAISYLKRFYLKNTVMDwHPKNVMLTA-LFLATKTTNNP-------- 135
Cdd:cd20530     1 GIDPETEARYRREGARFIQDVGTKLGLPYDTIATGIVYFHRFYMFHSFKD-FDRYVTAACcLFLAGKVEETPkkckdiik 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2051959599 136 ----ISLETYTTHIPRTAPSDVLDLEFLVAQSLGFE 167
Cdd:cd20530    80 tarsLLNDKQFAQFGDDPKEEVMVLERILLQTIKFD 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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