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Conserved domains on  [gi|2086904587|gb|KAG9320822|]
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hypothetical protein KVV02_004287 [Mortierella alpina]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
176-369 8.24e-35

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 137.74  E-value: 8.24e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 176 RVKPLQIHwhdKQPIYSAHFepGPKGR-LATAGGDGNVRLWkvvkdkekDSTNVEFLSSLNRHTAAVNVVRFSPTAECLA 254
Cdd:COG2319   196 LLRTLTGH---TGAVRSVAF--SPDGKlLASGSADGTVRLW--------DLATGKLLRTLTGHSGSVRSVAFSPDGRLLA 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 255 SAGDDGNIILWRPTesketisrfgeseedefereTWRVQSMMRGSLSDIYDLAWSPDGRYIISGSIDNTARIWDVKDAKC 334
Cdd:COG2319   263 SGSADGTVRLWDLA--------------------TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL 322

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2086904587 335 IHVIADHHHYVQGVAWDPLGEFVATQSSDRSVHIY 369
Cdd:COG2319   323 LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
GRAB pfam10375
GRAB domain; The GRAB (GRIP-related Arf-binding) domain is towards the C-terminus of Rud3 type ...
 55-103 1.42e-22

GRAB domain; The GRAB (GRIP-related Arf-binding) domain is towards the C-terminus of Rud3 type proteins. This domain is related to the GRIP domain, but the conserved tyrosine residue found at position 4 in all GRIP domains is replaced by a leucine residue. The Arf small GTPase is localized to the cis-Golgi where it recruits proteins via their GRAB domain, as part of the transport of cargo from the endoplasmic reticulum to the plasma membrane.


:

Pssm-ID: 431241  Cd Length: 49  Bit Score: 91.13  E-value: 1.42e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2086904587  55 NSQNTVDIPLISNLFISFLNIPRGDQKRFEILQLISGVLKFTDEQREQA 103
Cdd:pfam10375   1 SSEDTVDRQLVTNLLLSFLSIPRGDTKKFEILQLIANLLEWDDEQREQA 49
WD40 super family cl43672
WD40 repeat [General function prediction only];
275-654 3.43e-05

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.21  E-value: 3.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 275 SRFGESEEDEFERETWRVQSMMRGSLSDIYDLAWSPDGRYIISGSIDNTARIWDVKDAKCIHVIADHHHYVQGVAWDPLG 354
Cdd:COG2319    11 AASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDG 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 355 EFVATQSSDRSVHIYAfkldkhghvvvtslgRSTKLDLTKLRSVPQPPTSTGVTTNstnskGKAgdseMADGSADKD--- 431
Cdd:COG2319    91 RLLASASADGTVRLWD---------------LATGLLLRTLTGHTGAVRSVAFSPD-----GKT----LASGSADGTvrl 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 432 -DASKPARVgpKSFRLyHDETLTSffrrLSFTPDGAMLLTpAGqykapvlkhsaqkDDesgttpqpleletrNTVYVYar 510
Cdd:COG2319   147 wDLATGKLL--RTLTG-HSGAVTS----VAFSPDGKLLAS-GS-------------DD--------------GTVRLW-- 189

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 511 rDFNKG-PIAHLPGHKKPSVAIKCSP--------------VLYELR-EQLQPPSQGSNYQRRSqQAVQGDGKHekpkaps 574
Cdd:COG2319   190 -DLATGkLLRTLTGHTGAVRSVAFSPdgkllasgsadgtvRLWDLAtGKLLRTLTGHSGSVRS-VAFSPDGRL------- 260

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 575 vfgldyrfvYAVATQD-SILIYDTQQTAALALVSHiHYATFTDMTWSSDGCNLILTSSDGFCSIISFEEGELGTVYTPPK 653
Cdd:COG2319   261 ---------LASGSADgTVRLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHT 330


                  .
gi 2086904587 654 D 654
Cdd:COG2319   331 G 331
Atg16_CCD super family cl46300
Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family ...
 4-57 6.57e-04

Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family includes Saccharomyces cerevisiae Atg16 (also called cytoplasm to vacuole targeting protein 11, CVT11, or SAP18), human autophagy-related protein 16-1 (also called APG16-like 1, ATG16L1, or APG16L) and autophagy-related protein 16-2 (also called APG16-like 2, ATG16L2, WD repeat-containing protein 80 or WDR80), and similar proteins. Atg16 stabilizes the Atg5-Atg12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The Atg5-Atg12/Atg16 complex is required for efficient promotion of Atg8-conjugation to phosphatidylethanolamine and Atg8 localization to the pre-autophagosomal structure (PAS). Similarly, human ATG16L1 plays an essential role in autophagy and acts as a molecular scaffold which mediates protein-protein interactions essential for autophagosome formation. ATG16L2, though structurally similar to ATG16L1 and able to form a complex with the autophagy proteins Atg5 and Atg12, is not essential for autophagy. Single-nucleotide polymorphisms in ATG16L1 is associated with an increased risk of developing Crohn disease. Saccharomyces cerevisiae Atg16 contains an N-terminal domain (NTD) that interacts with the Atg5-Atg12 protein conjugate and a coiled-coil domain (CCD) that dimerizes and mediates self-assembly. Human ATG16L1 and ATG16L2 also contains an N-terminal region that binds Atg5, a CCD homologous to the yeast CCD, and a WD40 domain that represents approximately 50% of the full-length protein. This model corresponds to the CCD of Atg16 family proteins.


The actual alignment was detected with superfamily member cd22887:

Pssm-ID: 480640 [Multi-domain]  Cd Length: 91  Bit Score: 39.47  E-value: 6.57e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2086904587   4 EQLRHLTldvERARQLEREVKEKNLTIGKLR--HDAV-IQQGHLTEAMRRLKEENSQ 57
Cdd:cd22887    18 AELASLE---EEIKDLEEELKEKNKANEILNdeLIALqIENNLLEEKLRKLQEENDE 71
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
176-369 8.24e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 137.74  E-value: 8.24e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 176 RVKPLQIHwhdKQPIYSAHFepGPKGR-LATAGGDGNVRLWkvvkdkekDSTNVEFLSSLNRHTAAVNVVRFSPTAECLA 254
Cdd:COG2319   196 LLRTLTGH---TGAVRSVAF--SPDGKlLASGSADGTVRLW--------DLATGKLLRTLTGHSGSVRSVAFSPDGRLLA 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 255 SAGDDGNIILWRPTesketisrfgeseedefereTWRVQSMMRGSLSDIYDLAWSPDGRYIISGSIDNTARIWDVKDAKC 334
Cdd:COG2319   263 SGSADGTVRLWDLA--------------------TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL 322

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2086904587 335 IHVIADHHHYVQGVAWDPLGEFVATQSSDRSVHIY 369
Cdd:COG2319   323 LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 180-378 8.51e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 131.69  E-value: 8.51e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 180 LQIHwhdKQPIYSAHFEPGPKgRLATAGGDGNVRLWkvvkdkekDSTNVEFLSSLNRHTAAVNVVRFSPTAECLASAGDD 259
Cdd:cd00200     5 LKGH---TGGVTCVAFSPDGK-LLATGSGDGTIKVW--------DLETGELLRTLKGHTGPVRDVAASADGTYLASGSSD 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 260 GNIILWrPTESKETISRFgeseedeferetwrvqsmmRGSLSDIYDLAWSPDGRYIISGSIDNTARIWDVKDAKCIHVIA 339
Cdd:cd00200    73 KTIRLW-DLETGECVRTL-------------------TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLR 132

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2086904587 340 DHHHYVQGVAWDPLGEFVATQSSDRSVHIYAFKLDK-----HGH 378
Cdd:cd00200   133 GHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKcvatlTGH 176
GRAB pfam10375
GRAB domain; The GRAB (GRIP-related Arf-binding) domain is towards the C-terminus of Rud3 type ...
 55-103 1.42e-22

GRAB domain; The GRAB (GRIP-related Arf-binding) domain is towards the C-terminus of Rud3 type proteins. This domain is related to the GRIP domain, but the conserved tyrosine residue found at position 4 in all GRIP domains is replaced by a leucine residue. The Arf small GTPase is localized to the cis-Golgi where it recruits proteins via their GRAB domain, as part of the transport of cargo from the endoplasmic reticulum to the plasma membrane.


Pssm-ID: 431241  Cd Length: 49  Bit Score: 91.13  E-value: 1.42e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2086904587  55 NSQNTVDIPLISNLFISFLNIPRGDQKRFEILQLISGVLKFTDEQREQA 103
Cdd:pfam10375   1 SSEDTVDRQLVTNLLLSFLSIPRGDTKKFEILQLIANLLEWDDEQREQA 49
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 289-328 7.64e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.93  E-value: 7.64e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2086904587  289 TWRVQSMMRGSLSDIYDLAWSPDGRYIISGSIDNTARIWD 328
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
290-328 3.47e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.04  E-value: 3.47e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2086904587 290 WRVQSMMRGSLSDIYDLAWSPDGRYIISGSIDNTARIWD 328
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
275-654 3.43e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.21  E-value: 3.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 275 SRFGESEEDEFERETWRVQSMMRGSLSDIYDLAWSPDGRYIISGSIDNTARIWDVKDAKCIHVIADHHHYVQGVAWDPLG 354
Cdd:COG2319    11 AASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDG 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 355 EFVATQSSDRSVHIYAfkldkhghvvvtslgRSTKLDLTKLRSVPQPPTSTGVTTNstnskGKAgdseMADGSADKD--- 431
Cdd:COG2319    91 RLLASASADGTVRLWD---------------LATGLLLRTLTGHTGAVRSVAFSPD-----GKT----LASGSADGTvrl 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 432 -DASKPARVgpKSFRLyHDETLTSffrrLSFTPDGAMLLTpAGqykapvlkhsaqkDDesgttpqpleletrNTVYVYar 510
Cdd:COG2319   147 wDLATGKLL--RTLTG-HSGAVTS----VAFSPDGKLLAS-GS-------------DD--------------GTVRLW-- 189

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 511 rDFNKG-PIAHLPGHKKPSVAIKCSP--------------VLYELR-EQLQPPSQGSNYQRRSqQAVQGDGKHekpkaps 574
Cdd:COG2319   190 -DLATGkLLRTLTGHTGAVRSVAFSPdgkllasgsadgtvRLWDLAtGKLLRTLTGHSGSVRS-VAFSPDGRL------- 260

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 575 vfgldyrfvYAVATQD-SILIYDTQQTAALALVSHiHYATFTDMTWSSDGCNLILTSSDGFCSIISFEEGELGTVYTPPK 653
Cdd:COG2319   261 ---------LASGSADgTVRLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHT 330


                  .
gi 2086904587 654 D 654
Cdd:COG2319   331 G 331
PTZ00421 PTZ00421
coronin; Provisional
 187-341 1.50e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.27  E-value: 1.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 187 KQPIYSAHFEPGPKGRLATAGGDGNVRLWKVVKDKEKDSTNvEFLSSLNRHTAAVNVVRFSPTAE-CLASAGDDGNIILW 265
Cdd:PTZ00421   75 EGPIIDVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNIS-DPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVW 153

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2086904587 266 --RPTESKETISrfgeseedeferetwrvqsmmrgSLSD-IYDLAWSPDGRYIISGSIDNTARIWDVKDAKCIHVIADH 341
Cdd:PTZ00421  154 dvERGKAVEVIK-----------------------CHSDqITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAH 209
Atg16_CCD cd22887
Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family ...
 4-57 6.57e-04

Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family includes Saccharomyces cerevisiae Atg16 (also called cytoplasm to vacuole targeting protein 11, CVT11, or SAP18), human autophagy-related protein 16-1 (also called APG16-like 1, ATG16L1, or APG16L) and autophagy-related protein 16-2 (also called APG16-like 2, ATG16L2, WD repeat-containing protein 80 or WDR80), and similar proteins. Atg16 stabilizes the Atg5-Atg12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The Atg5-Atg12/Atg16 complex is required for efficient promotion of Atg8-conjugation to phosphatidylethanolamine and Atg8 localization to the pre-autophagosomal structure (PAS). Similarly, human ATG16L1 plays an essential role in autophagy and acts as a molecular scaffold which mediates protein-protein interactions essential for autophagosome formation. ATG16L2, though structurally similar to ATG16L1 and able to form a complex with the autophagy proteins Atg5 and Atg12, is not essential for autophagy. Single-nucleotide polymorphisms in ATG16L1 is associated with an increased risk of developing Crohn disease. Saccharomyces cerevisiae Atg16 contains an N-terminal domain (NTD) that interacts with the Atg5-Atg12 protein conjugate and a coiled-coil domain (CCD) that dimerizes and mediates self-assembly. Human ATG16L1 and ATG16L2 also contains an N-terminal region that binds Atg5, a CCD homologous to the yeast CCD, and a WD40 domain that represents approximately 50% of the full-length protein. This model corresponds to the CCD of Atg16 family proteins.


Pssm-ID: 439196 [Multi-domain]  Cd Length: 91  Bit Score: 39.47  E-value: 6.57e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2086904587   4 EQLRHLTldvERARQLEREVKEKNLTIGKLR--HDAV-IQQGHLTEAMRRLKEENSQ 57
Cdd:cd22887    18 AELASLE---EEIKDLEEELKEKNKANEILNdeLIALqIENNLLEEKLRKLQEENDE 71
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
176-369 8.24e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 137.74  E-value: 8.24e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 176 RVKPLQIHwhdKQPIYSAHFepGPKGR-LATAGGDGNVRLWkvvkdkekDSTNVEFLSSLNRHTAAVNVVRFSPTAECLA 254
Cdd:COG2319   196 LLRTLTGH---TGAVRSVAF--SPDGKlLASGSADGTVRLW--------DLATGKLLRTLTGHSGSVRSVAFSPDGRLLA 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 255 SAGDDGNIILWRPTesketisrfgeseedefereTWRVQSMMRGSLSDIYDLAWSPDGRYIISGSIDNTARIWDVKDAKC 334
Cdd:COG2319   263 SGSADGTVRLWDLA--------------------TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL 322

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2086904587 335 IHVIADHHHYVQGVAWDPLGEFVATQSSDRSVHIY 369
Cdd:COG2319   323 LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 180-378 8.51e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 131.69  E-value: 8.51e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 180 LQIHwhdKQPIYSAHFEPGPKgRLATAGGDGNVRLWkvvkdkekDSTNVEFLSSLNRHTAAVNVVRFSPTAECLASAGDD 259
Cdd:cd00200     5 LKGH---TGGVTCVAFSPDGK-LLATGSGDGTIKVW--------DLETGELLRTLKGHTGPVRDVAASADGTYLASGSSD 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 260 GNIILWrPTESKETISRFgeseedeferetwrvqsmmRGSLSDIYDLAWSPDGRYIISGSIDNTARIWDVKDAKCIHVIA 339
Cdd:cd00200    73 KTIRLW-DLETGECVRTL-------------------TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLR 132

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2086904587 340 DHHHYVQGVAWDPLGEFVATQSSDRSVHIYAFKLDK-----HGH 378
Cdd:cd00200   133 GHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKcvatlTGH 176
WD40 COG2319
WD40 repeat [General function prediction only];
178-369 1.14e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 134.27  E-value: 1.14e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 178 KPLQIHWHDKQPIYSAHFepGPKGR-LATAGGDGNVRLWKVVKDKEkdstnvefLSSLNRHTAAVNVVRFSPTAECLASA 256
Cdd:COG2319   153 KLLRTLTGHSGAVTSVAF--SPDGKlLASGSDDGTVRLWDLATGKL--------LRTLTGHTGAVRSVAFSPDGKLLASG 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 257 GDDGNIILWRPTesketisrfgeseedefereTWRVQSMMRGSLSDIYDLAWSPDGRYIISGSIDNTARIWDVKDAKCIH 336
Cdd:COG2319   223 SADGTVRLWDLA--------------------TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR 282

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2086904587 337 VIADHHHYVQGVAWDPLGEFVATQSSDRSVHIY 369
Cdd:COG2319   283 TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
178-369 3.85e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 129.65  E-value: 3.85e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 178 KPLQIHWHDKQPIYSAHFEPGPKgRLATAGGDGNVRLWKVVKDKEkdstnvefLSSLNRHTAAVNVVRFSPTAECLASAG 257
Cdd:COG2319   237 KLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGEL--------LRTLTGHSGGVNSVAFSPDGKLLASGS 307

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 258 DDGNIILWRpTESKETISRFgeseedeferetwrvqsmmRGSLSDIYDLAWSPDGRYIISGSIDNTARIWDVKDAKCIHV 337
Cdd:COG2319   308 DDGTVRLWD-LATGKLLRTL-------------------TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT 367

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2086904587 338 IADHHHYVQGVAWDPLGEFVATQSSDRSVHIY 369
Cdd:COG2319   368 LTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
163-369 5.48e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.18  E-value: 5.48e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 163 SNSTNPRSPTIAMRVKPLQIHWHDKQPIYSAHFEPGPKgRLATAGGDGNVRLWkvvkdkekDSTNVEFLSSLNRHTAAVN 242
Cdd:COG2319    54 GAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGR-LLASASADGTVRLW--------DLATGLLLRTLTGHTGAVR 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 243 VVRFSPTAECLASAGDDGNIILWRpTESKETISRFgeseedeferetwrvqsmmRGSLSDIYDLAWSPDGRYIISGSIDN 322
Cdd:COG2319   125 SVAFSPDGKTLASGSADGTVRLWD-LATGKLLRTL-------------------TGHSGAVTSVAFSPDGKLLASGSDDG 184

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2086904587 323 TARIWDVKDAKCIHVIADHHHYVQGVAWDPLGEFVATQSSDRSVHIY 369
Cdd:COG2319   185 TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 189-370 6.47e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 114.35  E-value: 6.47e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 189 PIYSAHFEPGPKgRLATAGGDGNVRLWkvvkdkekDSTNVEFLSSLNRHTAAVNVVRFSPTAECLASAGDDGNIILWRPT 268
Cdd:cd00200   137 WVNSVAFSPDGT-FVASSSQDGTIKLW--------DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 269 ESKETisrfgeseedeferetwrvqSMMRGSLSDIYDLAWSPDGRYIISGSIDNTARIWDVKDAKCIHVIADHHHYVQGV 348
Cdd:cd00200   208 TGKCL--------------------GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSL 267

                         170       180
                  ....*....|....*....|..
gi 2086904587 349 AWDPLGEFVATQSSDRSVHIYA 370
Cdd:cd00200   268 AWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
201-369 6.21e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.38  E-value: 6.21e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 201 GRLATAGGDGNVRLWkvvkdkekDSTNVEFLSSLNRHTAAVNVVRFSPTAECLASAGDDGNIILWRpTESKETISRFges 280
Cdd:COG2319    49 ARLAAGAGDLTLLLL--------DAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWD-LATGLLLRTL--- 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 281 eedeferetwrvqsmmRGSLSDIYDLAWSPDGRYIISGSIDNTARIWDVKDAKCIHVIADHHHYVQGVAWDPLGEFVATQ 360
Cdd:COG2319   117 ----------------TGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASG 180


                  ....*....
gi 2086904587 361 SSDRSVHIY 369
Cdd:COG2319   181 SDDGTVRLW 189
GRAB pfam10375
GRAB domain; The GRAB (GRIP-related Arf-binding) domain is towards the C-terminus of Rud3 type ...
 55-103 1.42e-22

GRAB domain; The GRAB (GRIP-related Arf-binding) domain is towards the C-terminus of Rud3 type proteins. This domain is related to the GRIP domain, but the conserved tyrosine residue found at position 4 in all GRIP domains is replaced by a leucine residue. The Arf small GTPase is localized to the cis-Golgi where it recruits proteins via their GRAB domain, as part of the transport of cargo from the endoplasmic reticulum to the plasma membrane.


Pssm-ID: 431241  Cd Length: 49  Bit Score: 91.13  E-value: 1.42e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2086904587  55 NSQNTVDIPLISNLFISFLNIPRGDQKRFEILQLISGVLKFTDEQREQA 103
Cdd:pfam10375   1 SSEDTVDRQLVTNLLLSFLSIPRGDTKKFEILQLIANLLEWDDEQREQA 49
WD40 COG2319
WD40 repeat [General function prediction only];
185-331 6.97e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.22  E-value: 6.97e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 185 HDKQPIYSAHFEPGPKgRLATAGGDGNVRLWKVVKDKEkdstnvefLSSLNRHTAAVNVVRFSPTAECLASAGDDGNIIL 264
Cdd:COG2319   286 GHSGGVNSVAFSPDGK-LLASGSDDGTVRLWDLATGKL--------LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRL 356

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2086904587 265 WRPtESKETISRFgeseedeferetwrvqsmmRGSLSDIYDLAWSPDGRYIISGSIDNTARIWDVKD 331
Cdd:COG2319   357 WDL-ATGELLRTL-------------------TGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 289-328 7.64e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.93  E-value: 7.64e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2086904587  289 TWRVQSMMRGSLSDIYDLAWSPDGRYIISGSIDNTARIWD 328
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
290-328 3.47e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.04  E-value: 3.47e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2086904587 290 WRVQSMMRGSLSDIYDLAWSPDGRYIISGSIDNTARIWD 328
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 229-265 3.59e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 3.59e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2086904587  229 EFLSSLNRHTAAVNVVRFSPTAECLASAGDDGNIILW 265
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 333-369 5.60e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 5.60e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2086904587  333 KCIHVIADHHHYVQGVAWDPLGEFVATQSSDRSVHIY 369
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
229-265 2.40e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 2.40e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2086904587 229 EFLSSLNRHTAAVNVVRFSPTAECLASAGDDGNIILW 265
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 303-350 2.45e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 43.42  E-value: 2.45e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2086904587 303 IYDLAWSPDGRYIISGSIDNTARIWDVKDAKCIHVIADHHHYVQGVAW 350
Cdd:pfam12894  41 VTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGW 88
WD40 COG2319
WD40 repeat [General function prediction only];
275-654 3.43e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.21  E-value: 3.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 275 SRFGESEEDEFERETWRVQSMMRGSLSDIYDLAWSPDGRYIISGSIDNTARIWDVKDAKCIHVIADHHHYVQGVAWDPLG 354
Cdd:COG2319    11 AASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDG 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 355 EFVATQSSDRSVHIYAfkldkhghvvvtslgRSTKLDLTKLRSVPQPPTSTGVTTNstnskGKAgdseMADGSADKD--- 431
Cdd:COG2319    91 RLLASASADGTVRLWD---------------LATGLLLRTLTGHTGAVRSVAFSPD-----GKT----LASGSADGTvrl 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 432 -DASKPARVgpKSFRLyHDETLTSffrrLSFTPDGAMLLTpAGqykapvlkhsaqkDDesgttpqpleletrNTVYVYar 510
Cdd:COG2319   147 wDLATGKLL--RTLTG-HSGAVTS----VAFSPDGKLLAS-GS-------------DD--------------GTVRLW-- 189

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 511 rDFNKG-PIAHLPGHKKPSVAIKCSP--------------VLYELR-EQLQPPSQGSNYQRRSqQAVQGDGKHekpkaps 574
Cdd:COG2319   190 -DLATGkLLRTLTGHTGAVRSVAFSPdgkllasgsadgtvRLWDLAtGKLLRTLTGHSGSVRS-VAFSPDGRL------- 260

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 575 vfgldyrfvYAVATQD-SILIYDTQQTAALALVSHiHYATFTDMTWSSDGCNLILTSSDGFCSIISFEEGELGTVYTPPK 653
Cdd:COG2319   261 ---------LASGSADgTVRLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHT 330


                  .
gi 2086904587 654 D 654
Cdd:COG2319   331 G 331
PTZ00421 PTZ00421
coronin; Provisional
 187-341 1.50e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.27  E-value: 1.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 187 KQPIYSAHFEPGPKGRLATAGGDGNVRLWKVVKDKEKDSTNvEFLSSLNRHTAAVNVVRFSPTAE-CLASAGDDGNIILW 265
Cdd:PTZ00421   75 EGPIIDVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNIS-DPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVW 153

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2086904587 266 --RPTESKETISrfgeseedeferetwrvqsmmrgSLSD-IYDLAWSPDGRYIISGSIDNTARIWDVKDAKCIHVIADH 341
Cdd:PTZ00421  154 dvERGKAVEVIK-----------------------CHSDqITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAH 209
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 298-387 4.03e-04

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 44.26  E-value: 4.03e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587  298 GSLSDIYDLAWSPDGRYIIsgSIDNTARIW--DVKDAKCIHVIAD-HHHYVQGVAWDPLGEFVA-TQSSDRSVH-IYAFK 372
Cdd:COG4946    386 GDLGRVFNPVWSPDGKKIA--FTDNRGRLWvvDLASGKVRKVDTDgYGDGISDLAWSPDSKWLAySKPGPNQLSqIFLYD 463

                           90
                   ....*....|....*
gi 2086904587  373 LDKHGHVVVTSLGRS 387
Cdd:COG4946    464 VETGKTVQLTDGRYD 478
WD40 pfam00400
WD domain, G-beta repeat;
333-369 4.12e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 4.12e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2086904587 333 KCIHVIADHHHYVQGVAWDPLGEFVATQSSDRSVHIY 369
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 306-371 4.99e-04

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 42.26  E-value: 4.99e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2086904587 306 LAWSPDGRYIISGSIDNTA---RIWDVKDAKCIHVIadHHHYVQGVAWDPLGEFVATQSS------DRSVHIYAF 371
Cdd:pfam08662 106 IFWSPFGRLVLLAGFGNLAgdiEFWDVVNKKKIATA--EASNATLCEWSPDGRYFLTATTaprlrvDNGFKIWHY 178
Atg16_CCD cd22887
Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family ...
 4-57 6.57e-04

Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family includes Saccharomyces cerevisiae Atg16 (also called cytoplasm to vacuole targeting protein 11, CVT11, or SAP18), human autophagy-related protein 16-1 (also called APG16-like 1, ATG16L1, or APG16L) and autophagy-related protein 16-2 (also called APG16-like 2, ATG16L2, WD repeat-containing protein 80 or WDR80), and similar proteins. Atg16 stabilizes the Atg5-Atg12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The Atg5-Atg12/Atg16 complex is required for efficient promotion of Atg8-conjugation to phosphatidylethanolamine and Atg8 localization to the pre-autophagosomal structure (PAS). Similarly, human ATG16L1 plays an essential role in autophagy and acts as a molecular scaffold which mediates protein-protein interactions essential for autophagosome formation. ATG16L2, though structurally similar to ATG16L1 and able to form a complex with the autophagy proteins Atg5 and Atg12, is not essential for autophagy. Single-nucleotide polymorphisms in ATG16L1 is associated with an increased risk of developing Crohn disease. Saccharomyces cerevisiae Atg16 contains an N-terminal domain (NTD) that interacts with the Atg5-Atg12 protein conjugate and a coiled-coil domain (CCD) that dimerizes and mediates self-assembly. Human ATG16L1 and ATG16L2 also contains an N-terminal region that binds Atg5, a CCD homologous to the yeast CCD, and a WD40 domain that represents approximately 50% of the full-length protein. This model corresponds to the CCD of Atg16 family proteins.


Pssm-ID: 439196 [Multi-domain]  Cd Length: 91  Bit Score: 39.47  E-value: 6.57e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2086904587   4 EQLRHLTldvERARQLEREVKEKNLTIGKLR--HDAV-IQQGHLTEAMRRLKEENSQ 57
Cdd:cd22887    18 AELASLE---EEIKDLEEELKEKNKANEILNdeLIALqIENNLLEEKLRKLQEENDE 71
PTZ00420 PTZ00420
coronin; Provisional
 234-368 6.31e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.93  E-value: 6.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086904587 234 LNRHTAAVNVVRFSPT-AECLASAGDDGNIILWRPTESKETISRFGESeedeferetwrvQSMMRGSLSDIYDLAWSPDG 312
Cdd:PTZ00420   70 LKGHTSSILDLQFNPCfSEILASGSEDLTIRVWEIPHNDESVKEIKDP------------QCILKGHKKKISIIDWNPMN 137

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2086904587 313 RYII-SGSIDNTARIWDVKDAKCIHVIaDHHHYVQGVAWDPLGEFVATQSSDRSVHI 368
Cdd:PTZ00420  138 YYIMcSSGFDSFVNIWDIENEKRAFQI-NMPKKLSSLKWNIKGNLLSGTCVGKHMHI 193
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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