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Conserved domains on  [gi|2095568366|gb|KAH0518919|]
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Ribosome biogenesis protein BOP1 [Microtus ochrogaster]

Protein Classification

WD repeat BOP1/ERB1 family ribosome biogenesis protein( domain architecture ID 12224376)

WD repeat BOP1/ERB1 family ribosome biogenesis protein is a component of a complex that is required for maturation of ribosomal RNAs and formation of the 60S ribosome

CATH:  2.130.10.10
Gene Ontology:  GO:0042254|GO:0003676|GO:0043021|GO:0006364
PubMed:  10322433|30069656|21468892
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BOP1NT smart01035
BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.
 27-285 3.24e-169

BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.


:

Pssm-ID: 214986  Cd Length: 264  Bit Score: 482.59  E-value: 3.24e-169
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366   27 YDDFPHVGYDLDGKRIYKPLRTrDELDQFLDKMDDPDFWRTVQDKMTGRDLRLTDEQVALVHRLQRGQFGDVSFNPYEPS 106
Cdd:smart01035   1 YDDYPHIGYDIDGKKIMKPAKG-DALDKFLDSIDDPNFWRTVYDKQTGKDVNLTDEELELIKRIQRGEIPDENYDPYEPY 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366  107 VDFFSGDVMIHPVTNRPADKRSFIPSLIEKEKVSRMVHAIKMGWIKPRRP------QDSTPRFYDLWAQEDPNAVLGRHK 180
Cdd:smart01035  80 VEWFTSEVEIMPLSNAPEPKRRFVPSKHEAKKIMKLVHAIRMGWIKPDKPpkekeeEEEYPKFYDLWADEDETETKFRII 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366  181 MHVPAPKLALPGHAESYNPPPEYLPTEEERLAWMHQEPCERKLNFLPQKFSSLRTVPAYGRFIQERFERCLDLYLCPRQR 260
Cdd:smart01035 160 MHIPAPKLPLPGHAESYNPPPEYLPTEEEKKEWEELEPEDRKLNFLPQKFDSLRKVPGYTNFIKERFERCLDLYLAPRQR 239

                          250       260
                   ....*....|....*....|....*
gi 2095568366  261 KMRVNVDPEDLIPKLPRPRDLQPFP 285
Cdd:smart01035 240 RNKLNIDPESLLPKLPSPKDLRPFP 264
WD40 COG2319
WD40 repeat [General function prediction only];
291-627 8.58e-46

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 167.40  E-value: 8.58e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366 291 VYKGHSDLVRCLSVSPGGQWLASGSDDGSVRLWEVATARCMRTVPV-GGVVRSIAWNPNpticlvaaamgdavlllnpal 369
Cdd:COG2319   115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGhSGAVTSVAFSPD--------------------- 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366 370 GDRLLVGSTD---QLLDAFTPPEEPTLQParwleaseeerqgglrlricHSKPVTQVTWHGRGDYLAvvlSSSGHTQVLI 446
Cdd:COG2319   174 GKLLASGSDDgtvRLWDLATGKLLRTLTG--------------------HTGAVRSVAFSPDGKLLA---SGSADGTVRL 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366 447 HQLSRRRSQSPFRRSHGQVQCVAFHPTRPFLLVASQ-RSVRIYHLLRQELTKKLMPNCKWVSSLAVHPAGDNIICGSYDS 525
Cdd:COG2319   231 WDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAdGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDG 310

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366 526 KLVWFDLDlSTKPYKVLRHHKKALRAVAFHPRYPLFASGSDDGSVIVChgmvynDLLQNPLLvpvKVLKGHTltrdLGVL 605
Cdd:COG2319   311 TVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW------DLATGELL---RTLTGHT----GAVT 376

                         330       340
                  ....*....|....*....|..
gi 2095568366 606 DVAFHPTQPWIFSSGADGTIRL 627
Cdd:COG2319   377 SVAFSPDGRTLASGSADGTVRL 398
 
Name Accession Description Interval E-value
BOP1NT smart01035
BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.
 27-285 3.24e-169

BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.


Pssm-ID: 214986  Cd Length: 264  Bit Score: 482.59  E-value: 3.24e-169
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366   27 YDDFPHVGYDLDGKRIYKPLRTrDELDQFLDKMDDPDFWRTVQDKMTGRDLRLTDEQVALVHRLQRGQFGDVSFNPYEPS 106
Cdd:smart01035   1 YDDYPHIGYDIDGKKIMKPAKG-DALDKFLDSIDDPNFWRTVYDKQTGKDVNLTDEELELIKRIQRGEIPDENYDPYEPY 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366  107 VDFFSGDVMIHPVTNRPADKRSFIPSLIEKEKVSRMVHAIKMGWIKPRRP------QDSTPRFYDLWAQEDPNAVLGRHK 180
Cdd:smart01035  80 VEWFTSEVEIMPLSNAPEPKRRFVPSKHEAKKIMKLVHAIRMGWIKPDKPpkekeeEEEYPKFYDLWADEDETETKFRII 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366  181 MHVPAPKLALPGHAESYNPPPEYLPTEEERLAWMHQEPCERKLNFLPQKFSSLRTVPAYGRFIQERFERCLDLYLCPRQR 260
Cdd:smart01035 160 MHIPAPKLPLPGHAESYNPPPEYLPTEEEKKEWEELEPEDRKLNFLPQKFDSLRKVPGYTNFIKERFERCLDLYLAPRQR 239

                          250       260
                   ....*....|....*....|....*
gi 2095568366  261 KMRVNVDPEDLIPKLPRPRDLQPFP 285
Cdd:smart01035 240 RNKLNIDPESLLPKLPSPKDLRPFP 264
BOP1NT pfam08145
BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.
 27-285 1.38e-168

BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.


Pssm-ID: 462371  Cd Length: 259  Bit Score: 480.88  E-value: 1.38e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366  27 YDDFPHVGYDLDGKRIYKPlRTRDELDQFLDKMDDPDFWRTVQDKMTGRDLRLTDEQVALVHRLQRGQFGDVSFNPYEPS 106
Cdd:pfam08145   1 YDDYPHIGYDIDGKKIMKP-AKGDALDKFLDSMDDPNAWRTVYDKLTGKDVVLTDEDLELIRRIQKGEFPDAGYDPYEPY 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366 107 VDFFSGDVMIHPVTNRPADKRSFIPSLIEKEKVSRMVHAIKMGWIKPRRPQDSTPRFYDLWAQEDPNAVLGRHKM-HVPA 185
Cdd:pfam08145  80 VEWFTSEDEIHPLSNAPEPKRRFIPSKWEAKKVMKLVRAIRMGRIKPRKPKEEEPKFYDLWADEDETEEERRRRPdHIPA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366 186 PKLALPGHAESYNPPPEYLPTEEERLAWMHQEPCERKLNFLPQKFSSLRTVPAYGRFIQERFERCLDLYLCPRQRKMRVN 265
Cdd:pfam08145 160 PKLPLPGHAESYNPPPEYLPTEEERKKWEEMDPEDRKLNFLPQKYDSLRLVPAYEKFIKERFERCLDLYLCPRVRKNRLN 239

                         250       260
                  ....*....|....*....|
gi 2095568366 266 VDPEDLIPKLPRPRDLQPFP 285
Cdd:pfam08145 240 IDPESLLPKLPSPKDLRPFP 259
WD40 COG2319
WD40 repeat [General function prediction only];
291-627 8.58e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 167.40  E-value: 8.58e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366 291 VYKGHSDLVRCLSVSPGGQWLASGSDDGSVRLWEVATARCMRTVPV-GGVVRSIAWNPNpticlvaaamgdavlllnpal 369
Cdd:COG2319   115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGhSGAVTSVAFSPD--------------------- 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366 370 GDRLLVGSTD---QLLDAFTPPEEPTLQParwleaseeerqgglrlricHSKPVTQVTWHGRGDYLAvvlSSSGHTQVLI 446
Cdd:COG2319   174 GKLLASGSDDgtvRLWDLATGKLLRTLTG--------------------HTGAVRSVAFSPDGKLLA---SGSADGTVRL 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366 447 HQLSRRRSQSPFRRSHGQVQCVAFHPTRPFLLVASQ-RSVRIYHLLRQELTKKLMPNCKWVSSLAVHPAGDNIICGSYDS 525
Cdd:COG2319   231 WDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAdGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDG 310

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366 526 KLVWFDLDlSTKPYKVLRHHKKALRAVAFHPRYPLFASGSDDGSVIVChgmvynDLLQNPLLvpvKVLKGHTltrdLGVL 605
Cdd:COG2319   311 TVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW------DLATGELL---RTLTGHT----GAVT 376

                         330       340
                  ....*....|....*....|..
gi 2095568366 606 DVAFHPTQPWIFSSGADGTIRL 627
Cdd:COG2319   377 SVAFSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 291-629 1.21e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 152.49  E-value: 1.21e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366 291 VYKGHSDLVRCLSVSPGGQWLASGSDDGSVRLWEVATARCMRTVPV-GGVVRSIAWNPNpticlvaaamgdavlllnpal 369
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGhTGPVRDVAASAD--------------------- 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366 370 GDRLLVGSTD---QLLDAFTPPEEPTLqparwleaseeerqgglrlrICHSKPVTQVTWHGRGDYLAvvlSSSGHTQVLI 446
Cdd:cd00200    63 GTYLASGSSDktiRLWDLETGECVRTL--------------------TGHTSYVSSVAFSPDGRILS---SSSRDKTIKV 119

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366 447 HQLSRRRSQSPFRrSH-GQVQCVAFHPTRPFLLVASQ-RSVRIYHLLRQELTKKLMPNCKWVSSLAVHPAGDNIICGSYD 524
Cdd:cd00200   120 WDVETGKCLTTLR-GHtDWVNSVAFSPDGTFVASSSQdGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSD 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366 525 SKL-VWfdlDLST-KPYKVLRHHKKALRAVAFHPRYPLFASGSDDGSVIVchgmvYNDLLQnpllVPVKVLKGHTLtrdl 602
Cdd:cd00200   199 GTIkLW---DLSTgKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRV-----WDLRTG----ECVQTLSGHTN---- 262

                         330       340
                  ....*....|....*....|....*..
gi 2095568366 603 GVLDVAFHPTQPWIFSSGADGTIRLFS 629
Cdd:cd00200   263 SVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
291-324 1.30e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.89  E-value: 1.30e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2095568366 291 VYKGHSDLVRCLSVSPGGQWLASGSDDGSVRLWE 324
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 291-324 1.88e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.09  E-value: 1.88e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2095568366  291 VYKGHSDLVRCLSVSPGGQWLASGSDDGSVRLWE 324
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
BOP1NT smart01035
BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.
 27-285 3.24e-169

BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.


Pssm-ID: 214986  Cd Length: 264  Bit Score: 482.59  E-value: 3.24e-169
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366   27 YDDFPHVGYDLDGKRIYKPLRTrDELDQFLDKMDDPDFWRTVQDKMTGRDLRLTDEQVALVHRLQRGQFGDVSFNPYEPS 106
Cdd:smart01035   1 YDDYPHIGYDIDGKKIMKPAKG-DALDKFLDSIDDPNFWRTVYDKQTGKDVNLTDEELELIKRIQRGEIPDENYDPYEPY 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366  107 VDFFSGDVMIHPVTNRPADKRSFIPSLIEKEKVSRMVHAIKMGWIKPRRP------QDSTPRFYDLWAQEDPNAVLGRHK 180
Cdd:smart01035  80 VEWFTSEVEIMPLSNAPEPKRRFVPSKHEAKKIMKLVHAIRMGWIKPDKPpkekeeEEEYPKFYDLWADEDETETKFRII 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366  181 MHVPAPKLALPGHAESYNPPPEYLPTEEERLAWMHQEPCERKLNFLPQKFSSLRTVPAYGRFIQERFERCLDLYLCPRQR 260
Cdd:smart01035 160 MHIPAPKLPLPGHAESYNPPPEYLPTEEEKKEWEELEPEDRKLNFLPQKFDSLRKVPGYTNFIKERFERCLDLYLAPRQR 239

                          250       260
                   ....*....|....*....|....*
gi 2095568366  261 KMRVNVDPEDLIPKLPRPRDLQPFP 285
Cdd:smart01035 240 RNKLNIDPESLLPKLPSPKDLRPFP 264
BOP1NT pfam08145
BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.
 27-285 1.38e-168

BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.


Pssm-ID: 462371  Cd Length: 259  Bit Score: 480.88  E-value: 1.38e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366  27 YDDFPHVGYDLDGKRIYKPlRTRDELDQFLDKMDDPDFWRTVQDKMTGRDLRLTDEQVALVHRLQRGQFGDVSFNPYEPS 106
Cdd:pfam08145   1 YDDYPHIGYDIDGKKIMKP-AKGDALDKFLDSMDDPNAWRTVYDKLTGKDVVLTDEDLELIRRIQKGEFPDAGYDPYEPY 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366 107 VDFFSGDVMIHPVTNRPADKRSFIPSLIEKEKVSRMVHAIKMGWIKPRRPQDSTPRFYDLWAQEDPNAVLGRHKM-HVPA 185
Cdd:pfam08145  80 VEWFTSEDEIHPLSNAPEPKRRFIPSKWEAKKVMKLVRAIRMGRIKPRKPKEEEPKFYDLWADEDETEEERRRRPdHIPA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366 186 PKLALPGHAESYNPPPEYLPTEEERLAWMHQEPCERKLNFLPQKFSSLRTVPAYGRFIQERFERCLDLYLCPRQRKMRVN 265
Cdd:pfam08145 160 PKLPLPGHAESYNPPPEYLPTEEERKKWEEMDPEDRKLNFLPQKYDSLRLVPAYEKFIKERFERCLDLYLCPRVRKNRLN 239

                         250       260
                  ....*....|....*....|
gi 2095568366 266 VDPEDLIPKLPRPRDLQPFP 285
Cdd:pfam08145 240 IDPESLLPKLPSPKDLRPFP 259
WD40 COG2319
WD40 repeat [General function prediction only];
291-627 8.58e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 167.40  E-value: 8.58e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366 291 VYKGHSDLVRCLSVSPGGQWLASGSDDGSVRLWEVATARCMRTVPV-GGVVRSIAWNPNpticlvaaamgdavlllnpal 369
Cdd:COG2319   115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGhSGAVTSVAFSPD--------------------- 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366 370 GDRLLVGSTD---QLLDAFTPPEEPTLQParwleaseeerqgglrlricHSKPVTQVTWHGRGDYLAvvlSSSGHTQVLI 446
Cdd:COG2319   174 GKLLASGSDDgtvRLWDLATGKLLRTLTG--------------------HTGAVRSVAFSPDGKLLA---SGSADGTVRL 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366 447 HQLSRRRSQSPFRRSHGQVQCVAFHPTRPFLLVASQ-RSVRIYHLLRQELTKKLMPNCKWVSSLAVHPAGDNIICGSYDS 525
Cdd:COG2319   231 WDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAdGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDG 310

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366 526 KLVWFDLDlSTKPYKVLRHHKKALRAVAFHPRYPLFASGSDDGSVIVChgmvynDLLQNPLLvpvKVLKGHTltrdLGVL 605
Cdd:COG2319   311 TVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW------DLATGELL---RTLTGHT----GAVT 376

                         330       340
                  ....*....|....*....|..
gi 2095568366 606 DVAFHPTQPWIFSSGADGTIRL 627
Cdd:COG2319   377 SVAFSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 291-629 1.21e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 152.49  E-value: 1.21e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366 291 VYKGHSDLVRCLSVSPGGQWLASGSDDGSVRLWEVATARCMRTVPV-GGVVRSIAWNPNpticlvaaamgdavlllnpal 369
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGhTGPVRDVAASAD--------------------- 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366 370 GDRLLVGSTD---QLLDAFTPPEEPTLqparwleaseeerqgglrlrICHSKPVTQVTWHGRGDYLAvvlSSSGHTQVLI 446
Cdd:cd00200    63 GTYLASGSSDktiRLWDLETGECVRTL--------------------TGHTSYVSSVAFSPDGRILS---SSSRDKTIKV 119

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366 447 HQLSRRRSQSPFRrSH-GQVQCVAFHPTRPFLLVASQ-RSVRIYHLLRQELTKKLMPNCKWVSSLAVHPAGDNIICGSYD 524
Cdd:cd00200   120 WDVETGKCLTTLR-GHtDWVNSVAFSPDGTFVASSSQdGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSD 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366 525 SKL-VWfdlDLST-KPYKVLRHHKKALRAVAFHPRYPLFASGSDDGSVIVchgmvYNDLLQnpllVPVKVLKGHTLtrdl 602
Cdd:cd00200   199 GTIkLW---DLSTgKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRV-----WDLRTG----ECVQTLSGHTN---- 262

                         330       340
                  ....*....|....*....|....*..
gi 2095568366 603 GVLDVAFHPTQPWIFSSGADGTIRLFS 629
Cdd:cd00200   263 SVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
396-629 4.61e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 95.75  E-value: 4.61e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366 396 ARWLEASEEERQGGLRLRICHSKPVTQVTWHGRGDYLAvvlSSSGHTQVLIHQLSRRRSQSPFRRSHGQVQCVAFHPTRP 475
Cdd:COG2319    15 DLALALLAAALGALLLLLLGLAAAVASLAASPDGARLA---AGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGR 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366 476 FLLVAS-QRSVRIYHLLRQELTKKLMPNCKWVSSLAVHPAGDNIICGSYDSKLVWFDLDlSTKPYKVLRHHKKALRAVAF 554
Cdd:COG2319    92 LLASASaDGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA-TGKLLRTLTGHSGAVTSVAF 170

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2095568366 555 HPRYPLFASGSDDGSVIVChgmvynDLLQNPLLvpvKVLKGHTltrdLGVLDVAFHPTQPWIFSSGADGTIRLFS 629
Cdd:COG2319   171 SPDGKLLASGSDDGTVRLW------DLATGKLL---RTLTGHT----GAVRSVAFSPDGKLLASGSADGTVRLWD 232
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 538-629 5.68e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.89  E-value: 5.68e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366 538 PYKVLRHHKKALRAVAFHPRYPLFASGSDDGSVIVChgmvynDLLQNPLLvpvKVLKGHTltrdLGVLDVAFHPTQPWIF 617
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVW------DLETGELL---RTLKGHT----GPVRDVAASADGTYLA 67

                          90
                  ....*....|..
gi 2095568366 618 SSGADGTIRLFS 629
Cdd:cd00200    68 SGSSDKTIRLWD 79
WD40 pfam00400
WD domain, G-beta repeat;
291-324 1.30e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.89  E-value: 1.30e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2095568366 291 VYKGHSDLVRCLSVSPGGQWLASGSDDGSVRLWE 324
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 291-324 1.88e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.09  E-value: 1.88e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2095568366  291 VYKGHSDLVRCLSVSPGGQWLASGSDDGSVRLWE 324
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
291-327 2.65e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.46  E-value: 2.65e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2095568366 291 VYKGHSDLVRCLSVSPGGQWLASGSDDGSVRLWEVAT 327
Cdd:COG2319   367 TLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
477-629 1.86e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.68  E-value: 1.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095568366 477 LLVASQRSVRIYHLLRQELTKKLMPNCKWVSSLAVHPAGDNIICGSYDSKLVWFDLDLSTKPyKVLRHHKKALRAVAFHP 556
Cdd:COG2319    10 AAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALL-ATLLGHTAAVLSVAFSP 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2095568366 557 RYPLFASGSDDGSVIVChgmvynDLLQNPLLVPvkvLKGHTltrdLGVLDVAFHPTQPWIFSSGADGTIRLFS 629
Cdd:COG2319    89 DGRLLASASADGTVRLW------DLATGLLLRT---LTGHT----GAVRSVAFSPDGKTLASGSADGTVRLWD 148
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 535-572 3.84e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 3.84e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2095568366  535 STKPYKVLRHHKKALRAVAFHPRYPLFASGSDDGSVIV 572
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKL 38
WD40 pfam00400
WD domain, G-beta repeat;
589-629 5.55e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 5.55e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2095568366 589 PVKVLKGHTLtrdlGVLDVAFHPTQPWIFSSGADGTIRLFS 629
Cdd:pfam00400   3 LLKTLEGHTG----SVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 589-629 6.59e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 6.59e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2095568366  589 PVKVLKGHTLtrdlGVLDVAFHPTQPWIFSSGADGTIRLFS 629
Cdd:smart00320   4 LLKTLKGHTG----PVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
537-572 2.26e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 2.26e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2095568366 537 KPYKVLRHHKKALRAVAFHPRYPLFASGSDDGSVIV 572
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKV 37
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 294-348 6.43e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.18  E-value: 6.43e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2095568366 294 GHSDLVRCLSVSPGGQWLASGSDDGSVRLWEVATARCMRTVPVG-GVVRSIAWNPN 348
Cdd:pfam12894  36 KEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGsDLITCLGWGEN 91
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 295-329 8.13e-04

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 41.98  E-value: 8.13e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2095568366 295 HSDLVRCLSVSPGGQWLASGSDDGSVRLWEVATAR 329
Cdd:pfam20426 123 HKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGR 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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