Dublecortin-like domain 1 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2113260056 129 KNVMVYRNGDSFFHGRKFVVNQRQFLTFEAFLNEVTSTIHASVAVRNIYTPRQGHRVTELEELQNGCPYVAAGFERFKR 207
Cdd:cd17150     1 KNVVVYRNGDPFFTGRKFVVNQRQFLTFEAFLNEVTSNIQAPVAVRNLYTPREGHRVTELGDLQNGGHYVAAGFERFKK 79

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2113260056 129 KNVMVYRNGDSFFHGRKFVVNQRQFLTFEAFLNEVTSTIHASVAVRNIYTPRQGHRVTELEELQNGCPYVAAGFERFKR 207
Cdd:cd17150     1 KNVVVYRNGDPFFTGRKFVVNQRQFLTFEAFLNEVTSNIQAPVAVRNLYTPREGHRVTELGDLQNGGHYVAAGFERFKK 79

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113260056  126 PVAKNVMVYRNGDSFFHGRKFVVNQRQFLTFEAFLNEVT--STIHASVAVRNIYTPRqGHRVTELEELQNGCPYVAAGFE 203
Cdd:smart00537   3 VKPKRIRFYRNGDRFFKGVRLVVNRKRFKSFEALLQDLTevVKLDLPHGVRKLYTLD-GKKVTSLDELEDGGSYVASGTE 81

                   ....*...
gi 2113260056  204 RFKRLDYL 211
Cdd:smart00537  82 AFKKVDYG 89

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113260056  250 PCIIHVFRNGDLLSPPFRLLLSKSTLQEWDAILGLLTEKANLRSG-AVRKLCQLDGVPVSGGEELVNGEYYVAVGVEKYK 328
Cdd:smart00537   5 PKRIRFYRNGDRFFKGVRLVVNRKRFKSFEALLQDLTEVVKLDLPhGVRKLYTLDGKKVTSLDELEDGGSYVASGTEAFK 84

                   ....*
gi 2113260056  329 NLPYF 333
Cdd:smart00537  85 KVDYG 89

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2113260056 129 KNVMVYRNGDSFFHGRKFVVNQRQFLTFEAFLNEVTSTIHASVAVRNIYTPRQGHRVTELEELQNGCPYVAAGFERFKR 207
Cdd:cd17150     1 KNVVVYRNGDPFFTGRKFVVNQRQFLTFEAFLNEVTSNIQAPVAVRNLYTPREGHRVTELGDLQNGGHYVAAGFERFKK 79

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2) and similar proteins; DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113260056 129 KNVMVYRNGDSFFHGRKFVVNQRQFLTFEAFLNEVTSTIHA-SVAVRNIYTPRQGHRVTELEELQNGCPYVAAGFERFKR 207
Cdd:cd17071     1 KIIVVYKNGDPFFPGKKFVVNERQVRTFDAFLNEVTSGIKApFGAVRSIYTPTGGHRVKDLDSLQNGGVYVAAGSERFKK 80

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2113260056 250 PCIIHVFRNGDLLSPPFRLLLSKSTLQEWDAILGLLTEKANLRSGAVRKLCQLDGVPVSGGEELVNGEYYVAVG 323
Cdd:cd16113     1 PKTIHVFPNGDLLHPPSKVLLTKRRLPNWDTVLEEVTEKVKLQTGAVRKLYTLDGKRISDPDELVNGGQYVAVG 74

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2113260056 129 KNVMVYRNGDSFFHGRKFVVNQRQFLTFEAFLNEVTSTIHASVAVRNIYTPRQGHRVTELEELQNGCPYVAAGFERFKR 207
Cdd:cd17151     1 KTILVYRNGDPFYQAHKVVIHRRRVKTFDALLRQLTETVKVPFGVRCLYTPRNGHRVKGLDDLQGGGKYVAAGRERFKK 79

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113260056  126 PVAKNVMVYRNGDSFFHGRKFVVNQRQFLTFEAFLNEVT--STIHASVAVRNIYTPRqGHRVTELEELQNGCPYVAAGFE 203
Cdd:smart00537   3 VKPKRIRFYRNGDRFFKGVRLVVNRKRFKSFEALLQDLTevVKLDLPHGVRKLYTLD-GKKVTSLDELEDGGSYVASGTE 81

                   ....*...
gi 2113260056  204 RFKRLDYL 211
Cdd:smart00537  82 AFKKVDYG 89

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113260056  250 PCIIHVFRNGDLLSPPFRLLLSKSTLQEWDAILGLLTEKANLRSG-AVRKLCQLDGVPVSGGEELVNGEYYVAVGVEKYK 328
Cdd:smart00537   5 PKRIRFYRNGDRFFKGVRLVVNRKRFKSFEALLQDLTEVVKLDLPhGVRKLYTLDGKKVTSLDELEDGGSYVASGTEAFK 84

                   ....*
gi 2113260056  329 NLPYF 333
Cdd:smart00537  85 KVDYG 89

Doublecortin-like domain 1 found in retinitis pigmentosa (RP)-like protein; RP-like protein family is part of doublecortin (DCX) family. It has double tandem DCX repeats that are associated with retinitis pigmentosa. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. RP-like proteins are colocalized to the photoreceptor and share a function in outer segment disc morphogenesis.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2113260056 129 KNVMVYRNGDSFFHGRKFVVNQRQFLTFEAFLNEVTSTIHASVAVRNIYTPRQGHRVTELEELQNGCPYVA 199
Cdd:cd16110     1 KNVTFYKDGDVHFSGVRVAINPRRYRTFDALLDELSRKVPLPFGVRSITTPRGRHSITSLEQLEDGGKYVC 71

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2113260056 129 KNVMVYRNGDSFFHGRKFVVNQRQFLTFEAFLNEVTSTIHASV-AVRNIYTPRqGHRVTELEELQNGCPYVAAG 201
Cdd:cd01617     1 KRITVFRNGDKNFKGVKVLVKPRRFRTFDQLLDELTEKLGLPTgGVRKLYTPS-GKLVKSLSDLEDGESYVVCG 73

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2113260056 253 IHVFRNGDLLSPPFRLLLSKSTLQEWDAILGLLTEKANLRSGAVRKLCQLDGVPVSGGEELVNGEYYVAVG 323
Cdd:cd01617     3 ITVFRNGDKNFKGVKVLVKPRRFRTFDQLLDELTEKLGLPTGGVRKLYTPSGKLVKSLSDLEDGESYVVCG 73

Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2); DCLK2 is a member of doublecortin (DCX) protein superfamily that functions as a microtubule-associated protein (MAP), and contains two conserved tubulin binding domains, which typically occur in tandem. The DCX domain has a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier (Ubiquitination) in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. In addition to microtubule binding domains, DCLK encodes a serine/threonine kinase-domain that is similar to Ca/calmodulin-dependent (Cam) protein kinases. Molecular actions of DCX members are less well characterized and it shows that DCLK2 members regulate cyclic AMP signaling. Unlike DCX, this DCLK has varying levels of expression throughout embryonic and adult life.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113260056 128 AKNVMVYRNGDSFFHGRKFVVNQRQFLTFEAFLNEVTSTIHASV----AVRNIYTPRQGHRVTELEELQNGCPYVAAGFE 203
Cdd:cd17141     2 AKKVRFYRNGDRYFKGLVYAVSSDRFRSFDALLMELTRSLSDNVnlpqGVRTIYTIDGSKKITSLDELLEGESYVCASNE 81

                  ....
gi 2113260056 204 RFKR 207
Cdd:cd17141    82 PFRK 85

Doublecortin-like domain 1 found in retinitis pigmentosa 1-like 1 (RP1L1) protein; RP1L1 is a member of the doublecortin (DCX) family. Its DCX domains occur in double tandem repeats. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX-domain of RP1L1 localizes to the photoreceptor and is genetically associated with retinitis pigmentosa.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113260056 129 KNVMVYRNGDSFFHGRKFVVNQRQFLTFEAFLNEVTSTIHASVAVRNIYTPRQGHRVTELEELQNGCPYV 198
Cdd:cd17146     1 KKITFYKSGDPQFGGVKMAVNKRTFKSFSALLDDLSQRVPLPFGVRTITTPRGTHSISRLEQLEDGGCYL 70

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2) and similar proteins; DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2113260056 252 IIHVFRNGDLLSPPFRLLLSKSTLQEWDAILGLLTEKANLRSGAVRKL-CQLDGVPVSGGEELVNGEYYVAVGVEKYK 328
Cdd:cd17071     2 IIVVYKNGDPFFPGKKFVVNERQVRTFDAFLNEVTSGIKAPFGAVRSIyTPTGGHRVKDLDSLQNGGVYVAAGSERFK 79

Dublecortin-like domain 2 found in retinitis pigmentosa 1 (RP1)-like protein; RP1, also termed oxygen-regulated protein 1, is a member of doublecortin (DCX) superfamily that contains double tandem repeats of the DCX domains. RP1 is associated with retinitis pigmentosa, which is a type of inherited blindness. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The RP1 protein is expressed in photoreceptors that is required for correct stacking of outer segment discs. RP1 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2113260056 129 KNVMVYRNGDSFFHgRKFVVNQRQFLTFEAFLNEVTSTIHASVAvrNIYTPrQGHRVTELEEL-QNGCPYVAAGFERFK 206
Cdd:cd17147     1 RKLIVFKNGDPGFK-HTLILNKKTTQSFEALLDHVSELMQFPVV--KLYTT-DGRRVDSLQALiLSSGAVVAAGREPFK 75

Dublecortin-like domain 2 found in neuronal migration protein doublecortin (DCX); DCX, also termed doublin or lissencephalin-X (Lis-XDCX), is a microtubule-associated protein (MAP). It belongs to the doublecortin (DCX) family, has double tandem DCX repeats, and is expressed in migrating neurons. Structure studies show that the N-terminal DCX domain has a stable ubiquitin-like fold. DCX is not only a unique MAP in terms of its structure, but also interacts with multiple additional proteins. Mutations in the human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113260056 250 PCIIHVFRNGDLLSPPFRLLLSKSTLQEWDAILGLLTEKANLRSGAVRKLCQLDGVPVSGGEELV-NGEYYVAVGVEKYK 328
Cdd:cd17142     4 PKLVTIIRSGVKPRKAVRVLLNKKTAHSFEQVLTDITEAIKLETGVVKKLYTLDGKQVTCLHDFFgDDDVFIACGPEKFR 83

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2113260056 253 IHVFRNGDLLSPPFRLLLSKSTLQEWDAILGLLTEKANLRSGAVRKL-CQLDGVPVSGGEELVNGEYYVAVGVEKYK 328
Cdd:cd17149     3 VLVYRNGDPFYAGRRLVINEKRVSSFEVFLKEVTGGVQAPFGAVRNIyTPRGGHRVRSLEQLQSGEQYVAAGRERFK 79

Dublecortin-like domain 2 found in doublecortin-like kinase 1 (DCLK1); DCLK1 is a member of doublecortin (DCX) protein family that functions as a microtubule-associated protein (MAP), and contains two conserved tubulin binding domains. The DCX domain has a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. In addition to microtubule binding domains, DCLK encodes a serine/threonine kinase-domain that is similar to Ca/calmodulin-dependent (Cam) protein kinases. DCLK1 appears to regulate cyclic AMP signaling and is involved in neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. Unlike DCX, the DCLK has varying levels of expression throughout embryonic and adult life.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113260056 250 PCIIHVFRNGDLLSPPFRLLLSKSTLQEWDAILGLLTEKANLRSGAVRKLCQLDGVPVSGGEELV-NGEYYVAVGVEKYK 328
Cdd:cd17143     4 PKLVTIIRSGVKPRKAVRILLNKKTAHSFEQVLTDITDAIKLDSGVVKRLYTLDGKQVMCLQDFFgDDDIFIACGPEKFR 83

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2113260056 133 VYRNGDSFFHGRKFVVNQRQFLTFEAFLNEVTSTIH-ASVAVRNIYTpRQGHRVTELEELQNGCPYVAAGFERFK 206
Cdd:cd17153     6 VFRNGDLLSPPFRLLIPKHMLQDWETILSLLTEKANlRTGAVRKLCT-LDGVPLSSGKELVSGQYYVAVGSEKFK 79