|
Name |
Accession |
Description |
Interval |
E-value |
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
9-1097 |
0e+00 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 776.39 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 9 VTELDNIWSEEYQSGFYDSCKNVKNGASGGKAVDFIGGGAKNYTQFLKFLGDK---KLLGSPFQINYKTEPSSPDQGMRA 85
Cdd:TIGR00917 112 VDGIQYYITDDFAAGMYNSCKNVKFGSSNSRALDFLGGGAKNFKEWFNWIGQKagvNLPGAPYGIAFLPTPCPVSSGMRP 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 86 LPIKPKACNDpdEAFRCSCVDCPEVCPEL--PEVKTDK--SCHVGL-LPCLSFAVILIYSVFLLavVAFSSYFTYRERRY 160
Cdd:TIGR00917 192 MNVSIYSCGD--ESLGCSCGDCPSAATCSckAKVPTQKkhSCSIKLgVKCVDFILAILYIVLVS--VFLGGGLLHPVRGK 267
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 161 RKPERVRLLqdpSPDDSE--------DEGDIVHAAGSLEQPSGVyklnsmLDSMFNSIGSTCARFPAITIVTSILLVGLL 232
Cdd:TIGR00917 268 KKTSQMGTL---SEADGEinsvnqqkDQNTPQRNWGQLSTVQGH------LARFFGKYGIWVARHPTLVICLSVSVVLLL 338
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 233 SLGWLRFAVETDPVRLWVSPTSPAAQEKEYFDANFGPFYRAEQVFV----VNEH---GPVLTYDTLSWWFDVESQIRRMI 305
Cdd:TIGR00917 339 CVGLIRFKVETRPVKLWVAPGSRAALEKQYFDTHFGPFYRIEQLIIatvqTSSHekaPEILTDDNLKLLFDIQKKVSQLF 418
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 306 S--PGRGLLLDDVCFKPTGD-ACVVQSLTGYFGGSGWNLHPDTWEE-----RIKHCANSPGDP-SCLPDFQQPLKPEMIL 376
Cdd:TIGR00917 419 AnyEGELITLDSPCFKPNHPyNCFIYSTCKKLQNMYSKLKPENYDDyggvdYVKYCFEHFTSPeSCLSAFGGPVDPTTVL 498
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 377 GGYEKSgNVLHAQALITTWVLNNHAQGTEGEADAIDWENNLKQLLYNvqEDAKERGLRVSFITEVSLEQELNKSSNTDAK 456
Cdd:TIGR00917 499 GGFSGN-NFSEASAFVVTFPVNNFVNKTNKTEKAVAWEKAFIQLAKD--ELLPMVQATISFSAERSIEDELKRESTADVI 575
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 457 IVVISYIIMFIYASLALGSATvTWKSLlnnpanvFVQSKFTLGIAGILIVLMSVSASVGLFSSAGIRVTLIIAEVIPFLV 536
Cdd:TIGR00917 576 TIAISYLVMFAYISLTLGDSP-RLKSL-------YVTSKVLLGLSGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLV 647
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 537 LAVGVDNIFLIVHEFERINV----SHPDEEI----DERVARAVGRIGPSIFLSALTETVAFALGVFVGMPAVRNFAIYAA 608
Cdd:TIGR00917 648 LAVGVDNIFILVFFYFYLEYfyrqVGVDNEQeltlERRLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAV 727
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 609 GAVFINAILQMTMFVSVLALNQRRVESLRADCIPCItvrkATSSGMFEEPAYNDQEGESLTQQFIRKIYANYLLDRRIKV 688
Cdd:TIGR00917 728 LAVFLDFLLQITAFVALLVLDFKRTEDKRVDCFPCI----KTSKSSISAEKGSGQRKAGLLTRYFKEVYAPVLLHWIVKI 803
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 689 AVVIVFLGIFTAGLALIPEVPLGLDQRIALPSDSYLVQYFNDLDIYFRTGPPVYFVTR-NVNVTERKHQQQLCGrFTTCE 767
Cdd:TIGR00917 804 VVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQDSYLQIYFASLTPLLEVGPPFYIVIKgDYNYTDFESQNKLCT-MGGCD 882
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 768 EFSLSFVLEqeskrqNVSYISGSAASWIDDFFYWLNPQQDCC--KENGQICFEDRTPA------WNISLYGMPTGDEFIH 839
Cdd:TIGR00917 883 KDSIVNVFN------NLSYIAKPASSWLDDYLVWLSPQASCCcrKFTNGTFCNGPDPQcfrcadLSSDAQGRPSTTQFKE 956
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 840 YLEKWIEAPTDASCPLGGKAPYTNALVIDSRRLMTNASHFRTSHTPLRSQDDYIKAYISARRIADGISKEHGIDVFPYSK 919
Cdd:TIGR00917 957 KLPWFLNALPSADCAKGGHAAYSSAVDLQGYATIIQASSFRTYHTPLNTQVDFINAMRAAQEFAAKVSRSSKMEVYPYSV 1036
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 920 PYIYFDQYVSIVQLTGTLLGCAVAIIFVITSIILGSVATGAV-VTATVVMIVVDIIGSMAIAGVSLNAVSLVNLVICVGI 998
Cdd:TIGR00917 1037 FYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLQLNALSVVnLIMSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGI 1116
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 999 GVEFCAHIARAFmfpsrtimgkTPTKFRGKDARAWTALVNVGGSVFSGITITKLLGICVLAFTRSKIFEIYYFRVWLALV 1078
Cdd:TIGR00917 1117 AIEFCTHINAQF----------STGKHFSRNHRAKEALGGMGSSVFSGITLTKLVGVVVLGFSRSEIFVVYYFRMYLALV 1186
|
1130
....*....|....*....
gi 2115075863 1079 IFAATHALIFLPVLLSYFG 1097
Cdd:TIGR00917 1187 LLGFLHGLVFLPVLLSVLG 1205
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
375-1096 |
1.12e-70 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 252.66 E-value: 1.12e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 375 ILGG--YEKSGNVLHAQALITTWVLNNHAQgtEGEADAIDWENNLKQLLYNVQEDAKergLRVSFITEVSLEQELNKSSN 452
Cdd:pfam02460 139 HFGGvdFEPPGNISYAKAIVLWYFLKFDEE--EVEEDSKEWEDELSQLLHNKYASEH---IQFTIFHDQILNDELVRNAL 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 453 TDAKIVVISYIIMFIYASLAlgsaTVTWKSLLNNpanvFVQSKFTLGIAGILIVLMSVSASVGLFSSAGIRVTLIIAeVI 532
Cdd:pfam02460 214 TLTPFFVIGFFLLLTFSIIV----SVTLSSYTID----WVRSKPILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVC-VT 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 533 PFLVLAVGVDNIFLIVHEFERINVSHPDEEideRVARAVGRIGPSIFLSALTETVAFALGVFVGMPAVRNFAIYAAGAVF 612
Cdd:pfam02460 285 PFLVLAIGVDDMFLMVAAWQRTTATLSVKK---RMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIF 361
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 613 INAILQMTMFVSVLALNQRRVESLRADCIPCITVRKATSSGMFEEPAYNdQEGESLTQQFIRKIYANYLLDRRIKVAVV- 691
Cdd:pfam02460 362 FDFIYQITFFAAIMAICAKPEAEGRHCLFVWATSSPQRIDSEGSEPDKS-HNIEQLKSRFFLDIYCPFLLNPSVRVCMLv 440
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 692 --IVFLGIFTAGLALIPEvplGLDQRIALPSDSYLVQYFNDLDIYF-RTGPPVYFVTRNvnvterkhqqqlCGRFTTCEe 768
Cdd:pfam02460 441 lfVVYIAIAIYGCVNIKE---GLEPDKLVLEDSPLVEYLSLREKHFwPEGLQIQVAVNN------------PPNLTIPE- 504
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 769 fSLSFVLEQESKRQNVSYISGSAASwiddfFYWLNPQQDCCKENGQICFEDRTPAWnislygmptgdeFIHYLEKWIEAP 848
Cdd:pfam02460 505 -SRDRMNEMVDEFENTPYSLGPNST-----LFWLREYENFLSTLNMEEEEDEEKEW------------SYGNLPSFLKAP 566
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 849 tdascplgGKAPYTNALVIDSRRLMTNASHFRTSHTPLRSQDDYIKAYISARRIADgisKEHGIDVFPYSKPYIYFDQYV 928
Cdd:pfam02460 567 --------GNSHWAGDLVWDDNTTMVTKFRFTLAGKGLSTWNDRTRALQEWRSIAD---QYPEFNVTVFDEDAPFADQYL 635
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 929 SIVQLTGTLLGCAVAIIFVITSIILGSVATGAVVTATVVMIVVDIIGSMAIAGVSLNAVSLVNLVICVGIGVEFCAHIAR 1008
Cdd:pfam02460 636 TILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFSVDFSAHIAY 715
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 1009 AFmFPSRtimGKTPtkfrgkDARAWTALVNVGGSVFSGITITkLLGICVLAFTRSKIFEIYYFRVWLaLVIFAATHALIF 1088
Cdd:pfam02460 716 HF-VRSR---GDTP------AERVVDALEALGWPVFQGGLST-ILGVLVLLFVPSYMVVVFFKTVFL-VVAIGLLHGLFI 783
|
....*...
gi 2115075863 1089 LPVLLSYF 1096
Cdd:pfam02460 784 LPIILSLF 791
|
|
| NPC1_N |
pfam16414 |
Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. ... |
2-130 |
3.28e-62 |
|
Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. This family of proteins mediates transport of cholesterol from the intestinal lumen to enterocytes. This domain contains a cholesterol-binding pocket.
Pssm-ID: 465110 Cd Length: 239 Bit Score: 212.08 E-value: 3.28e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 2 ASSGKLLVTELDNIWSEEYQSGFYDSCKNVKNGASGGKAVDFIGGGAKNYTQFLKFLGDKKLLGSPFQINYKTEPSSPDQ 81
Cdd:pfam16414 108 SVDGKEYVTELDYYISEEYASGFYDSCKDVKFPATNGYAMDLICGGACNYTRWLKFMGDKKNGGSPFQINFPDPPEEDPS 187
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 2115075863 82 GMRALPIKPKACN-DPDEAFRCSCVDCPEVCP---ELPEVKtDKSCHVGLLPC 130
Cdd:pfam16414 188 GMVPLNPNTKDCNeSYDASYACSCVDCPLSCPpppQLPPPP-HGPCKVGGLDG 239
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
491-646 |
5.95e-62 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 207.82 E-value: 5.95e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 491 FVQSKFTLGIAGILIVLMSVSASVGLFSSAGIRVTLIIAEVIPFLVLAVGVDNIFLIVHEFERINVSHPdeeIDERVARA 570
Cdd:pfam12349 1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLD---VSERIAEA 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2115075863 571 VGRIGPSIFLSALTETVAFALGVFVGMPAVRNFAIYAAGAVFINAILQMTMFVSVLALNQRRVESLRADCIPCITV 646
Cdd:pfam12349 78 LGEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRLDVACCIRV 153
|
|
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
159-1099 |
4.92e-57 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 215.52 E-value: 4.92e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 159 RYRKPERvRLLQDPSPDDSEDEGDIVHAAGSLEQPSGVY---KLNSMLDSMFNSIGSTCARFpaitIVTSILLVGLLSLG 235
Cdd:TIGR00918 1 RTAAPDS-EYLQRPSYCDAAFALEQIDKGKATGRRAPLWlraKFQRLLFTLGCYIQKHCGKV----LFVGLLVFSAFAVG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 236 wLRFA-VETDPVRLWVSPTSPAAQEKEYF------DANFGPfyraeQVFVVNEHGP---VLTYDTLSWWFDVESQIRRMI 305
Cdd:TIGR00918 76 -LRAAnIETNVEQLWVEVGGRVSQELAYTrqkigeEAMFTP-----QLLIQTPHQEganVLTPEALLQHLDSALKASRVH 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 306 SP--GRGLLLDDVCFKPTGDA---------------CVV-------------QSLTGYFGGSG---W-NLHP-------- 343
Cdd:TIGR00918 150 VYlyNRQWGLEHLCYKSGEPSteggyieqileklipCLIitpldcfwegaklQGGTAYLPGKPplqWtNLDPasfleelk 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 344 ------DTWEERIKH-----------CANsPGDPSCLP-----DFQQPL--------------------KPEMILGGYEK 381
Cdd:TIGR00918 230 qkmsqvESWEEMLKKaavgqgymerpCLN-PADPDCPDtapnkNSTQPPdvaavlsggcyglsakymhwQEELIVGGTKR 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 382 --SGNVLHAQALITTWVL------NNHAQG---------TEGEADAI--DWENNLKQLLYnvQEDAKERGLRVSFITEVS 442
Cdd:TIGR00918 309 nrSGKLLSAQALQSMFQLmtpkqmYEHFKGyykvhhigwNEEKAAAVleAWQRNFSEEVQ--QSLPKNSSQKILVFSSTT 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 443 LEQELNKSSNTDAKIVVISYIIMFIYASLALgsatVTWKSllnnpanvfVQSKFTLGIAGILIVLMSVSASVGLFSSAGI 522
Cdd:TIGR00918 387 LDDILKKFSDVSAIRIVSGYLLMLAYACLTM----LRWDC---------AKSQGSVGLAGVLLVALSVAAGLGLCALLGI 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 523 RVTLIIAEVIPFLVLAVGVDNIFLIVHEFERINVSHPDEeidERVARAVGRIGPSIFLSALTETVAFALGVFVGMPAVRN 602
Cdd:TIGR00918 454 SFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNIPFE---ERTGECLKRTGASVVLTSISNVTAFFMAALIPIPALRA 530
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 603 FAIYAAGAVFINAILQMTMFVSVLALNQRRVESLRADCIPCITVRKATSSGMFEEPAYND-------------------- 662
Cdd:TIGR00918 531 FSLQAAIVVVFNFAAVLLVFPAILSLDLRRREDRRLDIFCCFFSPCSARVIQIEPQAYADgsappvysshmqstvqlrte 610
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 663 --------------------QEGESLTQQ----------------------------------FIRKIYANYLLDRRIKV 688
Cdd:TIGR00918 611 ydpgtqhyyttneprshlsvQPSDPLSCQspdiagstrdllsqfedskaaclslpcarwtlatFAEKHYAPFLLQSWAKV 690
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 689 AVVIVFLGIFTAGLALIPEVPLGLDQRIALPSDSylvQYFNDLDIYFRtgppvYFVTRNVN-VTERK----HQQQLCgrF 763
Cdd:TIGR00918 691 VVIFLFLALLGLSLYGTTRVQDGLDLTDIVPRDT---NEHDFLDAQFR-----YFSFYNMYaVTQGNfdypTQQQLL--Y 760
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 764 TTCEEF-SLSFVLEQESkrqnvsyiSGSAASWIDDFFYWLNPQQDC-------------CKENGQ--------------- 814
Cdd:TIGR00918 761 DLHQSFsSVKYVLKEDN--------GQLPRMWLHYFRDWLQGLQKAfdedwrdgritkeNYRNGSddavlaykllvqtgh 832
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 815 ----ICFEDRTPAWNISLYGMPTGDEFIHYLEKWIeaptdASCPLGGKAPYTNaLVIDSRRLMtnasHFRTSHTP----- 885
Cdd:TIGR00918 833 rdkpVDKEQLTTQRLVNADGIINPNAFYIYLSAWV-----SNDPVAYAASQAN-IYPHPPEWL----HDKNDYDPenlri 902
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 886 -----------------LRSQDDYIKAYISARRIADGISKEhGIDVFPYSKPYIYFDQYVSIVQLTGTLLGCAVAIIFVI 948
Cdd:TIGR00918 903 paaepleyaqfpfylngLRETSQFVEAIEHVRAICNNYEGF-GLPSYPSGYPFLFWEQYMGLRHWLLLSISVVLACTFLV 981
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 949 TSIILGSVATGAVVTATVVMIVVDIIGSMAIAGVSLNAVSLVNLVICVGIGVEFCAHIARAFMfpsrtimgktpTKFRGK 1028
Cdd:TIGR00918 982 CALLLLNPWTAGLIVLVLALMTVELFGMMGLLGIKLSAIPVVILIASVGIGVEFTVHIALGFL-----------TAIGDR 1050
|
1130 1140 1150 1160 1170 1180 1190
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2115075863 1029 DARAWTALVNVGGSVFSGiTITKLLGICVLAFTRSKIFEIYYFRVWLALVIFAATHALIFLPVLLSYFGGE 1099
Cdd:TIGR00918 1051 NRRAVLALEHMFAPVLDG-ALSTLLGVLMLAGSEFDFIVRYFFAVLAVLTCLGVLNGLVLLPVLLSMFGPE 1120
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
204-1096 |
4.55e-37 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 150.40 E-value: 4.55e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 204 DSMFNSIGSTCARFPAITIVTSILLVGLLSLGWLRFAVETDPVRlWVSPTSPAAQEKEYFDANFGPfyrAEQVFVVNEHG 283
Cdd:COG1033 1 ERLMERLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFES-LLPEDDPSVQAYDEFEEEFGG---DDTVVVAVEGK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 284 P-VLTYDTLSWWFDVESQIRRMisPGrgllLDDVcfkptgdacvvQSLTGYFGGSGwNLHPDTWEERIKHcaNSPGDPSC 362
Cdd:COG1033 77 DdIFTPETLEALRELTEELEEI--PG----VDSV-----------TSLTNVRATEG-TEDGLTVEPLIPD--ELPASPEE 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 363 LPDFQQPLKPEMILGG--YEKSGNVlhaqALIttwVLNNHAQGTEGEADAIDWENNLKQLLynvqEDAKERGLRVSFITE 440
Cdd:COG1033 137 LAELREKVLSSPLYVGrlVSPDGKA----TLI---VVTLDPDPLSSDLDRKEVVAEIRAII----AKYEDPGVEVYLTGF 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 441 VSLEQELNKSSNTD-AKIVVISYIIMFIYASLALGSATVTwksllnnpanvfvqskftlgIAGILIVLMSVSASVGLFSS 519
Cdd:COG1033 206 PVLRGDIAEAIQSDlAIFFPLALLLILLLLFLFFRSLRGV--------------------LLPLLVVLLAVIWTLGLMGL 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 520 AGIRVTLIIAeVIPFLVLAVGVDN-IFLIVHEFERINVSHPdeeIDERVARAVGRIGPSIFLSALTETVAFALGVFVGMP 598
Cdd:COG1033 266 LGIPLSPLTI-LVPPLLLAIGIDYgIHLLNRYREERRKGLD---KREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIP 341
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 599 AVRNFAIYAAGAVFINAILQMTMFVSVLALNQRRVeslradcipcitvrkatssgmfeePAYNDQEGESLTQQFIRKIyA 678
Cdd:COG1033 342 PIRDFGIVAAIGVLLAFLTSLTLLPALLSLLPRPK------------------------PKTRRLKKPPELGRLLAKL-A 396
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 679 NYLLDRRikVAVVIVFLGIFTAGLALIPEVPLGLDQRIALPSDSYLVQ---YFND-------LDIYFRTGPPVYFVTRNV 748
Cdd:COG1033 397 RFVLRRP--KVILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSPIRQdldFIEEnfggsdpLEVVVDTGEPDGLKDPEV 474
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 749 nvterkhqqqlcgrfttceefsLSFVLEQESKRQNVSYISGSAAswIDDFFYWLNPQqdcckengqicFEDRTPAWnisl 828
Cdd:COG1033 475 ----------------------LKEIDRLQDYLESLPEVGKVLS--LADLVKELNQA-----------LNEGDPKY---- 515
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 829 YGMPTGDEFIHYLEKWIEAPtdascPLGGKAPYTNAlviDSRRLMTNAShfrtshTPLRSQDDYIKAYISARRIADGISK 908
Cdd:COG1033 516 YALPESRELLAQLLLLLSSP-----PGDDLSRFVDE---DYSAARVTVR------LKDLDSEEIKALVEEVRAFLAENFP 581
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 909 EHGIDVFPYSKPYIYFD--QYVSIVQLTGTLLgcAVAIIFVITSIILGSVATGAVVTATVVMIVVDIIGSMAIAGVSLNA 986
Cdd:COG1033 582 PDGVEVTLTGSAVLFAAinESVIESQIRSLLL--ALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNI 659
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 987 VSLVNLVICVGIGVEFCAHiaraFMfpsrtimgktpTKFR-----GKDARA--WTALVNVGGSV-FSGITITklLGICVL 1058
Cdd:COG1033 660 ATAVVASIALGIGVDYTIH----FL-----------SRYReerrkGGDLEEaiRRALRTTGKAIlFTSLTLA--AGFGVL 722
|
890 900 910
....*....|....*....|....*....|....*....
gi 2115075863 1059 AFTRSKIfeIYYFRVWLAL-VIFAATHALIFLPVLLSYF 1096
Cdd:COG1033 723 LFSSFPP--LADFGLLLALgLLVALLAALLLLPALLLLL 759
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
201-628 |
6.11e-11 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 66.81 E-value: 6.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 201 SMLDSMFNSIGSTCARFPAITIVTSILLVGLLSLGWLRFAVETDPVRlWVSPTSPAAQEKEYFDANFGPFYRAEQVFVVN 280
Cdd:COG1033 386 PELGRLLAKLARFVLRRPKVILVVALVLAVVSLYGISRLKVEYDFED-YLPEDSPIRQDLDFIEENFGGSDPLEVVVDTG 464
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 281 EHGPVLTYDTLSWWFDVESQIRRMISPGRglllddvcfkptgdacvVQSLTGYFGGSGWNLHPDTWEERIkhcanspgdp 360
Cdd:COG1033 465 EPDGLKDPEVLKEIDRLQDYLESLPEVGK-----------------VLSLADLVKELNQALNEGDPKYYA---------- 517
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 361 scLPDFQQPLK---------PEMILGGYEKSGnvlHAQALITTWVlNNHAQGTegeadAIDWENNLKQLLynvQEDAKER 431
Cdd:COG1033 518 --LPESRELLAqlllllsspPGDDLSRFVDED---YSAARVTVRL-KDLDSEE-----IKALVEEVRAFL---AENFPPD 583
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 432 GLRVSFITEVSLEQELNKSSNTDA-KIVVISYIIMFIYASLALGSatvtwksllnnpanvfvqskFTLGIAGILIVLMSV 510
Cdd:COG1033 584 GVEVTLTGSAVLFAAINESVIESQiRSLLLALLLIFLLLLLAFRS--------------------LRLGLISLIPNLLPI 643
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 511 SASVGLFSSAGIRVTLIIAEVIPfLVLAVGVDNIFLIVHEF--ERINvshpDEEIDERVARAVGRIGPSIFLSALTETVA 588
Cdd:COG1033 644 LLTFGLMGLLGIPLNIATAVVAS-IALGIGVDYTIHFLSRYreERRK----GGDLEEAIRRALRTTGKAILFTSLTLAAG 718
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 2115075863 589 FALGVFVGMPAVRNFAIYAAGAVFINAILQMTMFVSVLAL 628
Cdd:COG1033 719 FGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLL 758
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
503-759 |
6.71e-11 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 66.71 E-value: 6.71e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 503 ILIVLMSVSASVGL--FSSAGIRVTLIIAEVIPFLVLAVGVDNIFLIV---HEfERINvshpDEEIDERVARAVGRIGPS 577
Cdd:COG2409 200 LLTAGLAVGVALGLlaLLAAFTDVSSFAPNLLTMLGLGVGIDYALFLVsryRE-ELRA----GEDREEAVARAVATAGRA 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 578 IFLSALteTVAFALG--VFVGMPAVRNFAIYAAGAVFINAILQMTMFVSVLALNQRRVESLRadcIPCITVRKATSSGMF 655
Cdd:COG2409 275 VLFSGL--TVAIALLglLLAGLPFLRSMGPAAAIGVAVAVLAALTLLPALLALLGRRVFWPR---RPRRRRAAAPESGFW 349
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 656 eepayndqegesltqqfiRKIyANYLLDRRIKVAVVIV-FLGIFTAGLaliPEVPLGLDQRIALPSDSYLVQYFNDLDIY 734
Cdd:COG2409 350 ------------------RRL-ARAVVRRPVPVLVAAVaVLLALALPA---LGLRLGLPDADSLPADSPSRQGYDALAEH 407
|
250 260
....*....|....*....|....*..
gi 2115075863 735 F--RTGPPVYFVTRNVNVTERKHQQQL 759
Cdd:COG2409 408 FppGSNGPLTVVVESDDDLDPADLAAL 434
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
884-1097 |
7.13e-10 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 63.34 E-value: 7.13e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 884 TPLRSQDDYIKAYISARRIADGISKEhGIDVFPYSKPYIYFDQYVSIVQLTGTLLGCAVAIIFVITSIILGSVATGAVVT 963
Cdd:COG1033 171 DPLSSDLDRKEVVAEIRAIIAKYEDP-GVEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPL 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 964 ATVVMIVVDIIGSMAIAGVSLNAVSLVNLVICVGIGVEFCAHIARAFMFPSRtimgktptkfRGKDAR--AWTALVNVGG 1041
Cdd:COG1033 250 LVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYGIHLLNRYREERR----------KGLDKReaLREALRKLGP 319
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 2115075863 1042 SVFSGiTITKLLGICVLAFTRSKIFEiyYFRVWLAL-VIFAATHALIFLPVLLSYFG 1097
Cdd:COG1033 320 PVLLT-SLTTAIGFLSLLFSDIPPIR--DFGIVAAIgVLLAFLTSLTLLPALLSLLP 373
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
500-628 |
2.74e-08 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 57.92 E-value: 2.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 500 IAGILIVLMSVSASVGLFSSAGIRVTLIIAEVIPfLVLAVGVD-NIFLIVHEFERINVSHPDEEIdervARAVGRIGPSI 578
Cdd:TIGR00921 595 VFPLIAIGSGILWAIGLMGLRGIPSFLAMATTIS-IILGLGMDySIHLAERYFEERKEHGPKEAI----THTMERTGPGI 669
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 2115075863 579 FLSALTETVAFALGVFVGMPAVRNFAIYAAGAVFINAILQMTMFVSVLAL 628
Cdd:TIGR00921 670 LFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALLVL 719
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
503-633 |
8.43e-08 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 55.38 E-value: 8.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 503 ILIVLMSVSASVGLFS----SAGIRV---TLIIAEVIpflVLAVGVD-NIFLI--VHEFERINvshpdEEIDERVARAVG 572
Cdd:pfam03176 173 LLTVGLSLGAAQGLVAilahILGIGLstfALNLLVVL---LIAVGTDyALFLVsrYREELRAG-----EDREEAVIRAVR 244
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2115075863 573 RIGPSIFLSALteTVAFALG--VFVGMPAVRNFAIYAAGAVFINAILQMTMFVSVLALNQRRV 633
Cdd:pfam03176 245 GTGKVVTAAGL--TVAIAMLalSFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLALLGRWG 305
|
|
| actII |
TIGR00833 |
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ... |
442-735 |
1.04e-05 |
|
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 129913 [Multi-domain] Cd Length: 910 Bit Score: 49.97 E-value: 1.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 442 SLEQELNKSSNTDAKIVVIsyIIMFIYASLalgsatVTWKSLLnnpANVFVQSKFTLGIAGILIV--LMSVSASVGLFSS 519
Cdd:TIGR00833 170 SGDKDMNRITATTGIIVLI--ILLLVYRSP------ITMLVPL---VSVGFSVVVAQGIVSLLGIpgLIGVNAQTTVLLT 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 520 AgirvtliiaevipfLVLAVGVD-NIFLI--VHEFERINvshpdEEIDERVARAVGRIGPSIFLSALTETVAFALGVFVG 596
Cdd:TIGR00833 239 A--------------LVIGAGTDyAVFLTgrYHEERRKG-----ESLEEAAAEALRGTGKAILGSALTVAVAFLALSLAR 299
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 597 MPAVRNFAIYAAGAVFINAILQMTMFVSVLALNQRRVeslradCIPciTVRKATSSGMFeepayndqegesltqqfirki 676
Cdd:TIGR00833 300 LPSFKTLGVSCAVGVLVALLNAVTLTPALLTLEGREG------LMK--PGRKSKIRFIW--------------------- 350
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2115075863 677 yanylldRRIKVAVV-------IVFLGIFTAGLALIPEVPLGLDQRIALPSDSYLVQYFNDLDIYF 735
Cdd:TIGR00833 351 -------RRLGTAVVrrpwpilVTTLIISGVSLLALPLIRTGYDDEKMIPTDLESVQGYEAADRHF 409
|
|
| 2A060605 |
TIGR00920 |
3-hydroxy-3-methylglutaryl-coenzyme A reductase; [Transport and binding proteins, ... |
494-628 |
1.29e-05 |
|
3-hydroxy-3-methylglutaryl-coenzyme A reductase; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273339 [Multi-domain] Cd Length: 886 Bit Score: 49.47 E-value: 1.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 494 SKFTLGIAGILIVLMSVsasvgLFSSAgirvtliiaeVIPFLVLAVGVDN----IFLIVHEFERINV-------SHPDEE 562
Cdd:TIGR00920 88 SKYILGIAGLFTIFSSF-----VFSTA----------VIHFLGSELTGLNealpFFLLLIDLSKASAlakfalsSNSQDE 152
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2115075863 563 IDERVARAVGRIGPSIFLSALTETVAFALGVFVGMPAVRNFAIYAAGAVFINAILQMTMFVSVLAL 628
Cdd:TIGR00920 153 VRDNIARGMAILGPTITLDTVVETLVIGVGTMSGVRRLEVLCCFGCMSVLANYFVFMTFFPACLSL 218
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
932-1090 |
1.34e-05 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 49.47 E-value: 1.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 932 QLTGTLLGCAVAIIFVITSIILGSVATGAVVTATVVMIVVDIIGSMAIAGVSLNAVSLVNLVICVGIGVEFCAHIARAFM 1011
Cdd:COG4258 639 NDALWLLLLALLLILLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGIDYALFFTEGLL 718
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 1012 FPSRtimgktptkfrgkDARAWTALvnvggsVFSgiTITKLLGICVLAFtrSKIFEIYYFRVWLAL-VIFAATHALIFLP 1090
Cdd:COG4258 719 DKGE-------------LARTLLSI------LLA--ALTTLLGFGLLAF--SSTPALRSFGLTVLLgILLALLLAPLLAP 775
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
900-1097 |
3.17e-05 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 48.22 E-value: 3.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 900 RRIADGISKEhGIDVFPYSKPYIYFDQYVSIVQLTGTLLGCAVAIIFVITSIILGSVATGAVVTATVVMIVVDIIGSMAI 979
Cdd:COG2409 138 RDAVAAAPAP-GLTVYVTGPAALAADLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTAGLAVGVALGLLAL 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 980 AG----VSLNAVSLVnLVICVGIGVEFCAhiaraFMFpSRtimgktptkFR-----GKDAR--AWTALVNVGGSV-FSGI 1047
Cdd:COG2409 217 LAaftdVSSFAPNLL-TMLGLGVGIDYAL-----FLV-SR---------YReelraGEDREeaVARAVATAGRAVlFSGL 280
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 2115075863 1048 TItkLLGICVLAFtrskiFEIYYFRVwLAL-----VIFAATHALIFLPVLLSYFG 1097
Cdd:COG2409 281 TV--AIALLGLLL-----AGLPFLRS-MGPaaaigVAVAVLAALTLLPALLALLG 327
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
886-1093 |
8.89e-05 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 46.75 E-value: 8.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 886 LRSQDDY---IKAYISARRIADGISKEHGIDVFPYSKPYIYFDQYVSIVQLTGTLLGCAVAIIFVITSIILGSVATGAVV 962
Cdd:TIGR00921 144 LKSDADYkqvVPIYNDVERSLERTNPPSGKFLDVTGSPAINYDIEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLP 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 963 TATVVMIVVDIIGSMAIAGVSLNAVSLVNLVICVGIGVEFCAHIARAFMFPSRtimgktptKFRGKDARAWTALVNVGGS 1042
Cdd:TIGR00921 224 LVIILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRYEEERD--------IGRAKGEAIVTAVRRTGRA 295
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 2115075863 1043 VFsGITITKLLGIcvLAFTRSKIFEIYYFRVWLAL-VIFAATHALIFLPVLL 1093
Cdd:TIGR00921 296 VL-IALLTTSAGF--AALALSEFPMVSEFGLGLVAgLITAYLLTLLVLPALL 344
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
432-628 |
1.45e-03 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 42.68 E-value: 1.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 432 GLRVSFITEVSLEQELNKSSNTDAKIV-VISYIIMFIYASLALGSatvtwkslLNNPANVFVqskfTLGIAgiLIVLMSV 510
Cdd:TIGR03480 248 GVTVRLTGEVALSDEELATVSEGATVAgLLSFVLVLVLLWLALRS--------PRLVFAVLV----TLIVG--LILTAAF 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 511 SA-SVGlfssagiRVTLIiaeVIPFLVLAVGVDNIFLIVHEFERINVSHPDEEIDERVARAVGRIGPSIFLSALTETVAF 589
Cdd:TIGR03480 314 ATlAVG-------HLNLI---SVAFAVLFIGLGVDFAIQFSLRYREERFRGGNHREALSVAARRMGAALLLAALATAAGF 383
|
170 180 190
....*....|....*....|....*....|....*....
gi 2115075863 590 ALGVFVGMPAVRNFAIYAAGAVFINAILQMTMFVSVLAL 628
Cdd:TIGR03480 384 FAFLPTDYKGVSELGIIAGTGMFIALFVTLTVLPALLRL 422
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
499-628 |
2.11e-03 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 42.13 E-value: 2.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 499 GIAGILIVLMSVSASVGLFSSAGIRVTLIIAEVIPfLVLAVGVD-NIFLIVHEFERInvsHPDEEIDERVARAVGRIGPS 577
Cdd:TIGR00921 220 PLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVP-MLIGVGIDyGIQTLNRYEEER---DIGRAKGEAIVTAVRRTGRA 295
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 2115075863 578 IFLSALTETVAFALGVFVGMPAVRNFAIYAAGAVFINAILQMTMFVSVLAL 628
Cdd:TIGR00921 296 VLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALLQS 346
|
|
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
496-712 |
2.17e-03 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 42.40 E-value: 2.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 496 FTLGIAGILIVLMsvsasVGLFSsAGIRVTLIIAEVIPF-----------------------LVLAVG--VDN-IflIVH 549
Cdd:COG0841 335 KTLLEAILLVVLV-----VFLFL-RSWRATLIPAVAIPVsligtfavmyllgfslniltlfaLVLAIGivVDDaI--VVV 406
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 550 EferiNVS-HPDEEIDERVA--RAVGRIGPSIFLSALTeTVAfalgVFV------GMPAV--RNFAIYAAGAVFINAILQ 618
Cdd:COG0841 407 E----NIErHMEEGLSPLEAaiKGAREVAGAVIASTLT-LVA----VFLplafmgGITGQlfRQFALTVAIALLISLFVA 477
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 619 MT---MFVSVLalnqrrvesLRADcipcITVRKATSSGMFEEpayndqegeslTQQFIRKIYANyLLDR--RIKVAVVIV 693
Cdd:COG0841 478 LTltpALCARL---------LKPH----PKGKKGRFFRAFNR-----------GFDRLTRGYGR-LLRWalRHRKLTLLV 532
|
250
....*....|....*....
gi 2115075863 694 FLGIFTAGLALIPEVPLGL 712
Cdd:COG0841 533 ALALLALSVLLFGRLPTEF 551
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
496-617 |
2.50e-03 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 42.15 E-value: 2.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 496 FTLGIAGILIVLM----SVSASVGLFSSAGIRVTL--IIAEVipfLVLAVGVD-NIFLIVHeferinvsHPDEEIDERVA 568
Cdd:COG4258 659 RLRSLRRALRVLLppllAVLLTLAILGLLGIPLNLfhLIALL---LVLGIGIDyALFFTEG--------LLDKGELARTL 727
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 2115075863 569 RavgrigpSIFLSALTETVAFALGVFVGMPAVRNFAIYAAGAVFINAIL 617
Cdd:COG4258 728 L-------SILLAALTTLLGFGLLAFSSTPALRSFGLTVLLGILLALLL 769
|
|
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
922-1096 |
7.36e-03 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 40.47 E-value: 7.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 922 IYFDQ--YV--SIVQLTGTLLGcAVAIIFVITSIILGSVATGAVVTATvvmIVVDIIGS---MAIAGVSLNAVSLVNLVI 994
Cdd:COG0841 318 IVYDQseFIraSIEEVVKTLLE-AILLVVLVVFLFLRSWRATLIPAVA---IPVSLIGTfavMYLLGFSLNILTLFALVL 393
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2115075863 995 CVGIGV-------EfcaHIARAFMfpsrtiMGKTPtkfrgKDArAWTALVNVGGSVFSgITITkLlgICV---LAFTRSK 1064
Cdd:COG0841 394 AIGIVVddaivvvE---NIERHME------EGLSP-----LEA-AIKGAREVAGAVIA-STLT-L--VAVflpLAFMGGI 454
|
170 180 190
....*....|....*....|....*....|....*..
gi 2115075863 1065 IFEIYYFrvwLALVIFAAT-----HALIFLPVLLSYF 1096
Cdd:COG0841 455 TGQLFRQ---FALTVAIALlislfVALTLTPALCARL 488
|
|
| |
