|
Name |
Accession |
Description |
Interval |
E-value |
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
59-518 |
0e+00 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 584.05 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 59 LHFDYDCFYAQVVENKEPSLKSLPVGIKQKSILATCNYVARRRGVKKLMRISEARDICPDLVLVDGEDLTPFRDTSKILY 138
Cdd:cd01703 1 IHLDLDCFYAQVEEIRDPSLKSKPLGIQQKYIVVTCNYEARRLGVKKLMSIKDAKEICPDLVLVNGEDLTPFRDMSKKVY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 139 RVLRSFSWNDRAERLGLDEVFLDVSDMvsynldllnphglansffclsstdpelgfafdatgfagcvvapswssnssrgv 218
Cdd:cd01703 81 RLLRSYSWNDRVERLGFDENFMDVTEM----------------------------------------------------- 107
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 219 vesdeasgllrkRLLLASHLAYRIRLRIEQE-GYTSACGISVNKLLAKMVGSRNKPRNQTTLLALSRADTLSFVDQHSLR 297
Cdd:cd01703 108 ------------RLLVASHIAYEMRERIENElGLTCCAGIASNKLLAKLVGSVNKPNQQTTLLPPSCADLMDFMDLHDLR 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 298 SLPGIGGSMAAVMEQHTRSTAPDKPLKAGQVRLQHDVSPHLLEKLLQPLGLEKGIGQKTYRLLHGIDTAEVKFACDFPIQ 377
Cdd:cd01703 176 KIPGIGYKTAAKLEAHGISSVRDLQEFSNRNRQTVGAAPSLLELLLMVKEFGEGIGQRIWKLLFGRDTSPVKPASDFPQQ 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 378 IGIEDTYANTGLSNIAQITQQLIKLSASLIRRIRVDLTEpasnidgpEAVVWVARPRTLRLTTRQRHPTTgprppYNSNR 457
Cdd:cd01703 256 ISIEDSYKKCSLEEIREARNKIEELLASLLERMKQDLQE--------VKAGDGRRPHTLRLTLRRYTSTK-----KHYNR 322
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2286886203 458 TSRSQPLPSFVHSSPTQPaEDLAARLVEETLLPMFHKLNPPPTgtgPAGYNIGLINICVTG 518
Cdd:cd01703 323 ESKQAPIPSHVFQKLTGG-NEIAARPIEKILMRLFRELVPPKN---VKGFNLTLLNVCFTN 379
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
56-411 |
1.40e-37 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 142.59 E-value: 1.40e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 56 RIILHFDYDCFYAQVVENKEPSLKSLPV---GIKQKSILATCNYVARRRGVKKLMRISEARDICPDLVLVDGeDLTPFRD 132
Cdd:COG0389 1 RRILHVDMDAFYASVEQRDRPELRGKPVavgGDNNRGVVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPP-DFELYRD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 133 TSKILYRVLRSFSwnDRAERLGLDEVFLDVSDMVSYnldllnpHGlansffclsstDPElgfafdatgfagcvvapswss 212
Cdd:COG0389 80 VSRRVMAILERYT--PLVEPLSIDEAFLDVTGSARL-------FG-----------SAE--------------------- 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 213 nssrgvvesdeasgllrkrlllasHLAYRIRLRIEQE-GYTSACGISVNKLLAKMVGSRNKPRNQTTllaLSRADTLSFV 291
Cdd:COG0389 119 ------------------------AIARRIRRRIRREtGLTVSVGIAPNKFLAKIASDLAKPDGLTV---IPPGEVAAFL 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 292 DQHSLRSLPGIGGSMAAVMEQ---HTrstapdkplkAGQVRlqhDVSPHLLEKLLqplgleKGIGQKTYRLLHGIDTAEV 368
Cdd:COG0389 172 APLPVEKLWGVGPKTAEKLARlgiRT----------IGDLA---ALPRAELRRRF------GKVGERLYRLARGIDPRPV 232
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 2286886203 369 KfACDFPIQIGIEDTYAnTGLSNIAQITQQLIKLSASLIRRIR 411
Cdd:COG0389 233 E-PRRPRKSIGVERTFG-EDLTDLEELEAALRRLAERLAERLR 273
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
62-266 |
4.25e-36 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 132.31 E-value: 4.25e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 62 DYDCFYAQVVENKEPSLKSLPVGI---KQKSILATCNYVARRRGVKKLMRISEARDICPDLVLVDgEDLTPFRDTSKILY 138
Cdd:pfam00817 2 DMDAFFASVELLRDPELKGKPVAVgggNGRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVP-PDLELYRRASRKIF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 139 RVLRSFSwNDRAERLGLDEVFLDVSDMVsynldllnphglansffclsstdpelgfafdatgfagcvvapswssnssrgv 218
Cdd:pfam00817 81 EILRRFS-TPKVEQASIDEAFLDLTGLE---------------------------------------------------- 107
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 2286886203 219 vesdeasgllrKRLLLASHLAYRIRLRIEQE-GYTSACGISVNKLLAKM 266
Cdd:pfam00817 108 -----------KLFGAEEALAKRLRREIAEEtGLTCSIGIAPNKLLAKL 145
|
|
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
64-411 |
6.23e-28 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 115.22 E-value: 6.23e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 64 DCFYAQVVENKEPSLKSLPVGI----KQKSILATCNYVARRRGVKKLMRISEARDICPDLVLVDGeDLTPFRDTSKILYR 139
Cdd:PRK02406 2 DCFYAAVEMRDNPELRGKPVAVggspGRRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPG-RFDVYKEVSRQIRE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 140 VLRSFSwnDRAERLGLDEVFLDVSDmvsynldllNPHGlansffclsstdpelgfafdatgfagcvvapswssnssrgvv 219
Cdd:PRK02406 81 IFRRYT--DLIEPLSLDEAYLDVTD---------NKLC------------------------------------------ 107
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 220 esdeasgllrkrLLLASHLAYRIRLRIEQE-GYTSACGISVNKLLAKMVGSRNKPRNQTTLLAlsrADTLSFVDQHSLRS 298
Cdd:PRK02406 108 ------------IGSATLIAQEIRQDIFEElGLTASAGVAPNKFLAKIASDWNKPNGLFVITP---EEVDAFLATLPVEK 172
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 299 LPGIGGSMAAVMEQ---HTrstapdkplkAGQVRlQHDvsphlLEKLLQPLGleKgIGQKTYRLLHGIDTAEVKfacdfP 375
Cdd:PRK02406 173 IPGVGKVTAEKLHAlgiYT----------CADLQ-KYD-----LAELIRHFG--K-FGRRLYERARGIDERPVK-----P 228
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 2286886203 376 IQ----IGIEDTYAnTGLSNIAQITQQLIKLSASLIRRIR 411
Cdd:PRK02406 229 DRerksVGVERTFA-EDLYDLEACLAELPRLAEKLERRLE 267
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
59-518 |
0e+00 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 584.05 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 59 LHFDYDCFYAQVVENKEPSLKSLPVGIKQKSILATCNYVARRRGVKKLMRISEARDICPDLVLVDGEDLTPFRDTSKILY 138
Cdd:cd01703 1 IHLDLDCFYAQVEEIRDPSLKSKPLGIQQKYIVVTCNYEARRLGVKKLMSIKDAKEICPDLVLVNGEDLTPFRDMSKKVY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 139 RVLRSFSWNDRAERLGLDEVFLDVSDMvsynldllnphglansffclsstdpelgfafdatgfagcvvapswssnssrgv 218
Cdd:cd01703 81 RLLRSYSWNDRVERLGFDENFMDVTEM----------------------------------------------------- 107
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 219 vesdeasgllrkRLLLASHLAYRIRLRIEQE-GYTSACGISVNKLLAKMVGSRNKPRNQTTLLALSRADTLSFVDQHSLR 297
Cdd:cd01703 108 ------------RLLVASHIAYEMRERIENElGLTCCAGIASNKLLAKLVGSVNKPNQQTTLLPPSCADLMDFMDLHDLR 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 298 SLPGIGGSMAAVMEQHTRSTAPDKPLKAGQVRLQHDVSPHLLEKLLQPLGLEKGIGQKTYRLLHGIDTAEVKFACDFPIQ 377
Cdd:cd01703 176 KIPGIGYKTAAKLEAHGISSVRDLQEFSNRNRQTVGAAPSLLELLLMVKEFGEGIGQRIWKLLFGRDTSPVKPASDFPQQ 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 378 IGIEDTYANTGLSNIAQITQQLIKLSASLIRRIRVDLTEpasnidgpEAVVWVARPRTLRLTTRQRHPTTgprppYNSNR 457
Cdd:cd01703 256 ISIEDSYKKCSLEEIREARNKIEELLASLLERMKQDLQE--------VKAGDGRRPHTLRLTLRRYTSTK-----KHYNR 322
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2286886203 458 TSRSQPLPSFVHSSPTQPaEDLAARLVEETLLPMFHKLNPPPTgtgPAGYNIGLINICVTG 518
Cdd:cd01703 323 ESKQAPIPSHVFQKLTGG-NEIAARPIEKILMRLFRELVPPKN---VKGFNLTLLNVCFTN 379
|
|
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
59-490 |
3.05e-42 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 155.37 E-value: 3.05e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 59 LHFDYDCFYAQVVENKEPSLKSLPVGI---KQKSILATCNYVARRRGVKKLMRISEARDICPDLVLVDGeDLTPFRDTSK 135
Cdd:cd03586 1 IHIDMDAFYASVEQRDNPELKGKPVAVggsSDRGVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPP-RFDKYREVSR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 136 ILYRVLRSFSwnDRAERLGLDEVFLDVSDMVSYNLDllnphglansffclsstdpelgfafdatgfagcvvapswssnss 215
Cdd:cd03586 80 QIMEILREYT--PLVEPLSIDEAYLDVTDYVRLFGS-------------------------------------------- 113
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 216 rgvvesdeasgllrkrlllASHLAYRIRLRIEQE-GYTSACGISVNKLLAKMVGSRNKPRNQTTllaLSRADTLSFVDQH 294
Cdd:cd03586 114 -------------------ATEIAKEIRARIREEtGLTASAGIAPNKFLAKIASDLNKPNGLTV---IPPEDVEEFLAPL 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 295 SLRSLPGIGGSMAAVMEQHTRSTAPDkplkagqvrLQHdVSPHLLEKLLqplgleKGIGQKTYRLLHGIDTAEVKfACDF 374
Cdd:cd03586 172 PVRKIPGVGKVTAEKLKELGIKTIGD---------LAK-LDVELLKKLF------GKSGRRLYELARGIDNRPVE-PDRE 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 375 PIQIGIEDTYANTgLSNIAQITQQLIKLSASLIRRIRvdltepASNIdgpeavvwvaRPRTLRLTTRQRHPTTgprppyn 454
Cdd:cd03586 235 RKSIGVERTFSED-LTDPEELLEELLELAEELAERLR------KRGL----------KGRTVTVKLKYADFST------- 290
|
410 420 430
....*....|....*....|....*....|....*.
gi 2286886203 455 snrTSRSQPLPSFVHSSPTqpAEDLAARLVEETLLP 490
Cdd:cd03586 291 ---RTRSRTLPEPTDDAED--IYELALELLEELLDG 321
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
56-411 |
1.40e-37 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 142.59 E-value: 1.40e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 56 RIILHFDYDCFYAQVVENKEPSLKSLPV---GIKQKSILATCNYVARRRGVKKLMRISEARDICPDLVLVDGeDLTPFRD 132
Cdd:COG0389 1 RRILHVDMDAFYASVEQRDRPELRGKPVavgGDNNRGVVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPP-DFELYRD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 133 TSKILYRVLRSFSwnDRAERLGLDEVFLDVSDMVSYnldllnpHGlansffclsstDPElgfafdatgfagcvvapswss 212
Cdd:COG0389 80 VSRRVMAILERYT--PLVEPLSIDEAFLDVTGSARL-------FG-----------SAE--------------------- 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 213 nssrgvvesdeasgllrkrlllasHLAYRIRLRIEQE-GYTSACGISVNKLLAKMVGSRNKPRNQTTllaLSRADTLSFV 291
Cdd:COG0389 119 ------------------------AIARRIRRRIRREtGLTVSVGIAPNKFLAKIASDLAKPDGLTV---IPPGEVAAFL 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 292 DQHSLRSLPGIGGSMAAVMEQ---HTrstapdkplkAGQVRlqhDVSPHLLEKLLqplgleKGIGQKTYRLLHGIDTAEV 368
Cdd:COG0389 172 APLPVEKLWGVGPKTAEKLARlgiRT----------IGDLA---ALPRAELRRRF------GKVGERLYRLARGIDPRPV 232
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 2286886203 369 KfACDFPIQIGIEDTYAnTGLSNIAQITQQLIKLSASLIRRIR 411
Cdd:COG0389 233 E-PRRPRKSIGVERTFG-EDLTDLEELEAALRRLAERLAERLR 273
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
62-266 |
4.25e-36 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 132.31 E-value: 4.25e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 62 DYDCFYAQVVENKEPSLKSLPVGI---KQKSILATCNYVARRRGVKKLMRISEARDICPDLVLVDgEDLTPFRDTSKILY 138
Cdd:pfam00817 2 DMDAFFASVELLRDPELKGKPVAVgggNGRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVP-PDLELYRRASRKIF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 139 RVLRSFSwNDRAERLGLDEVFLDVSDMVsynldllnphglansffclsstdpelgfafdatgfagcvvapswssnssrgv 218
Cdd:pfam00817 81 EILRRFS-TPKVEQASIDEAFLDLTGLE---------------------------------------------------- 107
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 2286886203 219 vesdeasgllrKRLLLASHLAYRIRLRIEQE-GYTSACGISVNKLLAKM 266
Cdd:pfam00817 108 -----------KLFGAEEALAKRLRREIAEEtGLTCSIGIAPNKLLAKL 145
|
|
| PolY_Pol_eta |
cd01702 |
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ... |
60-518 |
6.18e-33 |
|
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.
Pssm-ID: 176456 [Multi-domain] Cd Length: 359 Bit Score: 130.13 E-value: 6.18e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 60 HFDYDCFYAQVVENKEPSLKSLPVGIKQ-KSILATcNYVARRRGVKKLMRISEARDICPDLVLV------DGED------ 126
Cdd:cd01702 2 HIDMDAFFAQVEQVRLGLLRNDPVAVVQwNSIIAV-SYAARAFGVTRFMTIDEAKKKCPDLILAhvatykKGEDeadyhe 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 127 ----------LTPFRDTSKILYRVLRSFSwnDRAERLGLDEVFLDvsdmvsynldllnphglansffclsstdpelgfaf 196
Cdd:cd01702 81 npsparhkvsLDPYRRASRKILNILKRFG--DVVEKASIDEAYLD----------------------------------- 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 197 datgfagcvvapswssnssrgvvesdeasgllrkrllLASHLAYRIRLRIEQE-GYTSACGISVNKLLAKMVGSRNKPRN 275
Cdd:cd01702 124 -------------------------------------LGSRIVEEIRQQVYDElGYTCSAGIAHNKMLAKLASGMNKPNA 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 276 QTTLLALSRADTLSFVDQHSLRSLPG-IGGSMAAVMEQHTRSTApdkplkAGQVRLQHDVSPHLLEKLlqplglekgiGQ 354
Cdd:cd01702 167 QTILRNDAVASFLSSLPITSIRGLGGkLGEEIIDLLGLPTEGDV------AGFRSSESDLQEHFGEKL----------GE 230
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 355 KTYRLLHGIDTAEVKfacDFPI--QIGIEDTYANTGLSNIAQITQQLIKLSASLIRRIRVDLTEPasnidgpeavvwVAR 432
Cdd:cd01702 231 WLYNLLRGIDHEPVK---PRPLpkSMGSSKNFPGKTALSTEDVQHWLLVLASELNSRLEDDRYEN------------NRR 295
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 433 PRTLRLTTRQRHPTTgprppynsnRTSRSQPLPSFVhssPTQPAEDlAARLVEETLLPMFHKLNPPPtgtgpagynIGLI 512
Cdd:cd01702 296 PKTLVLSLRQRGDGV---------RRSRSCALPRYD---AQKIVKD-AFKLIKAINEEGLGLAWNYP---------LTLL 353
|
....*.
gi 2286886203 513 NICVTG 518
Cdd:cd01702 354 SLSFTK 359
|
|
| PolY |
cd00424 |
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ... |
59-413 |
5.64e-32 |
|
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176453 [Multi-domain] Cd Length: 343 Bit Score: 126.71 E-value: 5.64e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 59 LHFDYDCFYAQVVENKEPSLKSLPVGIKQKSI----LATCNYVARRRGVKKLMRISEARDICPDLVLVDgEDLTPFRDTS 134
Cdd:cd00424 1 LHIDFDNFFASVEQLARPELKGRPVVVVPFNSdstcVIACSYEARKYGVKRGMPVREARKMCPNLILVP-ARLDLYRRLS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 135 KILYRVLRSFSwnDRAERLGLDEVFLDVSDMVsynldllnphglansffclsstdpelgfafdatgfagcvvapswssns 214
Cdd:cd00424 80 ERLLSELEEVA--PLVEVASIDELFLDLTGSA------------------------------------------------ 109
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 215 srgvvesdeasgllrKRLLLASHLAYRIRLRIEQE--GYTSACGISVNKLLAKMVGSRNKPRNQTTLLalsRADTLSFVD 292
Cdd:cd00424 110 ---------------RLLGLGSEVALRIKRHIAEQlgGITASIGIASNKLLAKLAAKYAKPDGLTILD---PEDLPGFLS 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 293 QHSLRSLPGIGGSMAAVMEqhtrstapdkplkagqvrlQHDVSPHLLEKLLQPLGLEKGI----GQKTYRLLHGIDTAEV 368
Cdd:cd00424 172 KLPLTDLPGIGAVTAKRLE-------------------AVGINPIGDLLAASPDALLALWggvsGERLWYALRGIDDEPL 232
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 2286886203 369 KFAcDFPIQIGIEDTYAnTGLSNIAQITQQLIKLSASLIRRIRVD 413
Cdd:cd00424 233 SPP-RPRKSFSHERVLP-RDSRNAEDARPLLRLLLEKLARRLRRD 275
|
|
| PolY_Rev1 |
cd01701 |
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ... |
53-499 |
4.40e-29 |
|
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.
Pssm-ID: 176455 [Multi-domain] Cd Length: 404 Bit Score: 119.73 E-value: 4.40e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 53 DDERIILHFDYDCFYAQVVENKEPSLKSLPV----GIKQKSILATCNYVARRRGVKKLMRISEARDICPDLVLVDgEDLT 128
Cdd:cd01701 44 DLQRIIMHVDFDCFFVSVSIRNRPDLKGKPVavchGKGPNSEIASCNYEARSYGIKNGMWVGQAKKLCPQLVTLP-YDFE 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 129 PFRDTSKILYRVLRSFSWNDRAerLGLDEVFLDVSDMVSYnldllnphglansffclSSTDPElgfafdatgfagcvvap 208
Cdd:cd01701 123 AYEEVSLTFYEILASYTDNIEA--VSCDEALIDITSLLEE-----------------TYELPE----------------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 209 swssnssrgvvesdeasgllrkrlLLASHLAYRIRlriEQEGYTSACGISVNKLLAKMVGSRNKPRNQttlLALSRADTL 288
Cdd:cd01701 167 ------------------------ELAEAIRNEIR---ETTGCSASVGIGPNILLARLATRKAKPDGQ---YHLSAEKVE 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 289 SFVDQHSLRSLPGIGGSMAAVMEQHTRSTapdkplkAGQVRLQHDVsphlLEKLLQPLGleKGIGQKTYRLLHGIDTAEV 368
Cdd:cd01701 217 EFLSQLKVGDLPGVGSSLAEKLVKLFGDT-------CGGLELRSKT----KEKLQKVLG--PKTGEKLYDYCRGIDDRPV 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 369 KfACDFPIQIGIEDTYAnTGLSNIAQITQQLIKLSASLIRRIRVDltepasnidgpeavvwVARPRTLRLTTRQRHPTTG 448
Cdd:cd01701 284 T-GEKERKSVSAEINYG-IRFTNVDDVEQFLQRLSEELSKRLEES----------------NVTGRQITLKLMKRAPGAP 345
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 2286886203 449 PRPP-YNSNRT----SRSQPLPsfvhsSPTQPAEDLAARLVeetllPMFHKLNPPP 499
Cdd:cd01701 346 IEPPkYMGHGIcdsfSKSSTLG-----VATDDSGVIGTEAK-----KLFRDLSIPP 391
|
|
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
64-411 |
6.23e-28 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 115.22 E-value: 6.23e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 64 DCFYAQVVENKEPSLKSLPVGI----KQKSILATCNYVARRRGVKKLMRISEARDICPDLVLVDGeDLTPFRDTSKILYR 139
Cdd:PRK02406 2 DCFYAAVEMRDNPELRGKPVAVggspGRRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPG-RFDVYKEVSRQIRE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 140 VLRSFSwnDRAERLGLDEVFLDVSDmvsynldllNPHGlansffclsstdpelgfafdatgfagcvvapswssnssrgvv 219
Cdd:PRK02406 81 IFRRYT--DLIEPLSLDEAYLDVTD---------NKLC------------------------------------------ 107
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 220 esdeasgllrkrLLLASHLAYRIRLRIEQE-GYTSACGISVNKLLAKMVGSRNKPRNQTTLLAlsrADTLSFVDQHSLRS 298
Cdd:PRK02406 108 ------------IGSATLIAQEIRQDIFEElGLTASAGVAPNKFLAKIASDWNKPNGLFVITP---EEVDAFLATLPVEK 172
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 299 LPGIGGSMAAVMEQ---HTrstapdkplkAGQVRlQHDvsphlLEKLLQPLGleKgIGQKTYRLLHGIDTAEVKfacdfP 375
Cdd:PRK02406 173 IPGVGKVTAEKLHAlgiYT----------CADLQ-KYD-----LAELIRHFG--K-FGRRLYERARGIDERPVK-----P 228
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 2286886203 376 IQ----IGIEDTYAnTGLSNIAQITQQLIKLSASLIRRIR 411
Cdd:PRK02406 229 DRerksVGVERTFA-EDLYDLEACLAELPRLAEKLERRLE 267
|
|
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
56-483 |
1.09e-21 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 97.79 E-value: 1.09e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 56 RIILHFDYDCFYAQVVENKEPSLKSLPVGI-----KQKSILATCNYVARRRGVKKLMRISEARDICPDLVLVDgEDLTPF 130
Cdd:PRK01810 5 RVIFHVDMNSFFASVEIAYDPSLQGKPLAVagnekERKGIIVTCSYEARAYGIRTTMPLWEAKRLCPQLIVRR-PNFDRY 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 131 RDTSKILYRVLRSFSwnDRAERLGLDEVFLDVSDmvsynldllnphglansffCLSSTDPelgfafdatgfagcvvapsw 210
Cdd:PRK01810 84 REASRQMFQILSEFT--PLVQPVSIDEGYLDITD-------------------CYALGSP-------------------- 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 211 ssnssrgvvesdeasgllrkrlllaSHLAYRIRLRIEQE-GYTSACGISVNKLLAKMVGSRNKPRNQTTLlalsRADTLS 289
Cdd:PRK01810 123 -------------------------LEIAKMIQQRLLTElQLPCSIGIAPNKFLAKMASDMKKPLGITVL----RKRDVP 173
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 290 FVdqhsLRSLP-----GIGgsmaavmeqhtRSTApdKPLKAGQVRLQHDVS---PHLLEKLLqplglekGI-GQKTYRLL 360
Cdd:PRK01810 174 EM----LWPLPvgemhGIG-----------EKTA--EKLKDIGIQTIGDLAkadEHILRAKL-------GInGVRLQRRA 229
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 361 HGIDTAEVKfacdfPIQIGIEDTYAN-TGLS----NIAQITQQLIKLSASLIRRIRvdltepasnidgPEAVVwvarPRT 435
Cdd:PRK01810 230 NGIDDRPVD-----PEAIYQFKSVGNsTTLShdmdEEKELLDVLRRLSKSVSKRLQ------------KKTVV----SYN 288
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 2286886203 436 LRLTTRqrhpttgprppYNSNRT-SRSQPLpsfvhSSPTQPAEDL---AARL 483
Cdd:PRK01810 289 VQIMIR-----------YHDRRTiTRSKTL-----KNPIWEKRDIfqaASRL 324
|
|
| PTZ00205 |
PTZ00205 |
DNA polymerase kappa; Provisional |
59-311 |
6.36e-18 |
|
DNA polymerase kappa; Provisional
Pssm-ID: 140232 [Multi-domain] Cd Length: 571 Bit Score: 87.38 E-value: 6.36e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 59 LHFDYDCFYAQVVENKEPSLKSLPVGIKQKSILATCNYVARRRGVKKLMRISEARDICPDLVLVDgEDLTPFRDTSKILY 138
Cdd:PTZ00205 136 IHLDMDMFYAAVEIKKHPEYAAIPLAIGTMTMLQTANYVARGRGIRQGMPGFLALKICPNLLILP-PDFDAYNEESNTVR 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 139 RVLRSFSWNDRAerLGLDEVFLDVSDMVSynldllnphglansffclsstdpelgfAFDATGFAgcvvapswssnssrgv 218
Cdd:PTZ00205 215 RIVAEYDPNYIS--FGLDELTLEVSAYIE---------------------------RFEGTKTA---------------- 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 219 veSDEASGLlrkrlllashlayRIRLRIEQEgYTSACGISVNKLLAKMVGSRNKPRNQTTLLALSRADTLSFVDQHSLRS 298
Cdd:PTZ00205 250 --EDVASEL-------------RVRVFGETK-LTASAGIGPTAALAKIASNINKPNGQHDLNLHTRGDVMTYVRDLGLRS 313
|
250
....*....|...
gi 2286886203 299 LPGIGGSMAAVME 311
Cdd:PTZ00205 314 VPGVGKVTEALLK 326
|
|
| PRK01216 |
PRK01216 |
DNA polymerase IV; Validated |
57-303 |
8.18e-16 |
|
DNA polymerase IV; Validated
Pssm-ID: 179251 [Multi-domain] Cd Length: 351 Bit Score: 79.06 E-value: 8.18e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 57 IILHFDYDCFYAQVVENKEPSLKSLPVGI-------KQKSILATCNYVARRRGVKKLMRISEARDICPDLVLVdgedltP 129
Cdd:PRK01216 2 IILFVDFDYFFAQVEEVLNPSLKGKPVVVcvysgrfEDSGAVATANYEARKLGIKAGMPIVEAKKILPNAVYL------P 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 130 FRD------TSKILyRVLRSFSwnDRAERLGLDEVFLDVSDMVSYNldllnphglansffclsstdpelgfafdatgfag 203
Cdd:PRK01216 76 MRKevyqqvSNRIM-KLLREYS--EKIEIASIDEAYLDISDKVKNY---------------------------------- 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 204 cvvapswssnssrgvvesDEASGLLRKrlllashlayrIRLRI-EQEGYTSACGISVNKLLAKMVGSRNKPRNqttLLAL 282
Cdd:PRK01216 119 ------------------QDAYNLGLE-----------IKNKIlEKEKITVTVGISKNKVFAKIAADMAKPNG---IKVI 166
|
250 260
....*....|....*....|.
gi 2286886203 283 SRADTLSFVDQHSLRSLPGIG 303
Cdd:PRK01216 167 DDEEVKRFINELDIADIPGIG 187
|
|
| PRK02794 |
PRK02794 |
DNA polymerase IV; Provisional |
58-525 |
1.38e-15 |
|
DNA polymerase IV; Provisional
Pssm-ID: 179473 [Multi-domain] Cd Length: 419 Bit Score: 79.21 E-value: 1.38e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 58 ILHFDYDCFYAQVVENKEPSLKSLPV--GIKQKSILATCNYVARRRGVKKLMRISEARDICPDLVLVDGeDLTPFRDTSK 135
Cdd:PRK02794 38 IAHIDCDAFYASVEKRDNPELRDKPViiGGGKRGVVSTACYIARIHGVRSAMPMFKALKLCPDAVVIKP-DMEKYVRVGR 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 136 ILYRVLRSFSwnDRAERLGLDEVFLDvsdmvsynldllnphglansffcLSSTDPELGfafdatgfagcvvAPSwssnss 215
Cdd:PRK02794 117 EVRAMMQALT--PLVEPLSIDEAFLD-----------------------LSGTERLHG-------------APP------ 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 216 rgvvesdeasgllrkrlllASHLAyRIRLRIEQE-GYTSACGISVNKLLAKMVGSRNKPRNQTtllALSRADTLSFVDQH 294
Cdd:PRK02794 153 -------------------AVVLA-RFARRVEREiGITVSVGLSYNKFLAKIASDLDKPRGFS---VIGRAEALAFLAPK 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 295 SLRSLPGIGGSMAAVMEQHTRSTAPDKpLKAGQVRLQhdvsphllekllQPLGlekGIGQKTYRLLHGIDTAEVKfaCDF 374
Cdd:PRK02794 210 PVGIIWGVGPATAARLARDGIRTIGDL-QRADEADLM------------RRFG---SMGLRLWRLARGIDDRKVS--PDR 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 375 PIQ-IGIEDTYaNTGLSNIAQITQQLIKLSASLIRRIRvdltepASNIDGpeAVVwvarprTLRLTT---RQRhpttgpr 450
Cdd:PRK02794 272 EAKsVSAETTF-ETDLSDFEDLEPILWRLSEKVSRRLK------AAGLAG--RTV------TLKLKTadfRLR------- 329
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2286886203 451 ppynsnrtSRSQPLPsfvhsSPTQpaedLAARLVEETlLPMFHKLnppPTGTgpagyNIGLINICVTGMV-ASGAD 525
Cdd:PRK02794 330 --------TRRRTLE-----DPTQ----LADRIFRTA-RELLEKE---TDGT-----AFRLIGIGVSDLSpADEAD 379
|
|
| PRK14133 |
PRK14133 |
DNA polymerase IV; Provisional |
55-164 |
1.84e-14 |
|
DNA polymerase IV; Provisional
Pssm-ID: 184529 [Multi-domain] Cd Length: 347 Bit Score: 75.14 E-value: 1.84e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 55 ERIILHFDYDCFYAQVVENKEPSLKSLPV---GIKQKSILATCNYVARRRGVKKLMRISEARDICPDLVLVDGEdLTPFR 131
Cdd:PRK14133 2 DRVIIHVDMDAFFASVEQMDNPKLKGKPVivgGISERGVVSTCSYEARKYGVHSAMPVFMAKKRCPHGIFLPVR-HERYK 80
|
90 100 110
....*....|....*....|....*....|...
gi 2286886203 132 DTSKILYRVLrsFSWNDRAERLGLDEVFLDVSD 164
Cdd:PRK14133 81 EVSKNIFKIL--YEVTPIVEPVSIDEAYLDITN 111
|
|
| PRK03103 |
PRK03103 |
DNA polymerase IV; Reviewed |
55-315 |
2.36e-13 |
|
DNA polymerase IV; Reviewed
Pssm-ID: 235104 [Multi-domain] Cd Length: 409 Bit Score: 72.34 E-value: 2.36e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 55 ERIILHFDYDCFYAQVVENKEPSLKSLPV----------GIkqksILATCnYVARRRGVKKLMRISEARDICPDLVLVdg 124
Cdd:PRK03103 2 ERVILLVDMQSFYASVEKAANPELKGRPVivsgdperrsGV----VLAAC-PLAKAYGVKTAERLWEAQQKCPDLVVV-- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 125 edlTP----FRDTSKILYRVLRSFSwnDRAERLGLDEVFLDvsdmVSYNLDLLNPhglansffclsstdPElgfafdatg 200
Cdd:PRK03103 75 ---KPrmqrYIDVSLQITRILEDFT--DLVEPFSIDEQFLD----VTGSQKLFGS--------------PL--------- 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 201 fagcvvapswssnssrgvvesdeasgllrkrlllasHLAYRIRLRIEQE-GYTSACGISVNKLLAKMVGSRNKPRNQTTL 279
Cdd:PRK03103 123 ------------------------------------EIAQKIQQRIMREtGVYARVGIGPNKLLAKMACDNFAKKNPDGL 166
|
250 260 270
....*....|....*....|....*....|....*.
gi 2286886203 280 LALSRADTLSFVDQHSLRSLPGIGGSmaavMEQHTR 315
Cdd:PRK03103 167 FTLDKEDVPADLWPLPVRKLFGVGSR----MEKHLR 198
|
|
| PRK03858 |
PRK03858 |
DNA polymerase IV; Validated |
58-163 |
1.89e-12 |
|
DNA polymerase IV; Validated
Pssm-ID: 179663 [Multi-domain] Cd Length: 396 Bit Score: 69.24 E-value: 1.89e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 58 ILHFDYDCFYAQVVENKEPSLKSLPVGIKQKSILAtCNYVARRRGVKKLMRISEARDICPDLVLVDGEdLTPFRDTSKIL 137
Cdd:PRK03858 6 ILHADLDSFYASVEQRDDPALRGRPVIVGGGVVLA-ASYEAKAYGVRTAMGGRQARRLCPQAVVVPPR-MSAYSRASKAV 83
|
90 100
....*....|....*....|....*.
gi 2286886203 138 YRVLRSFSwnDRAERLGLDEVFLDVS 163
Cdd:PRK03858 84 FEVFRDTT--PLVEGLSIDEAFLDVG 107
|
|
| PRK03348 |
PRK03348 |
DNA polymerase IV; Provisional |
56-413 |
5.85e-12 |
|
DNA polymerase IV; Provisional
Pssm-ID: 235118 [Multi-domain] Cd Length: 454 Bit Score: 68.04 E-value: 5.85e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 56 RIILHFDYDCFYAQVVENKEPSLKSLPV---GIKQKSILATCNYVARRRGVKKLMRISEARDICPDLVLVdgedLTP--- 129
Cdd:PRK03348 5 RWVLHLDMDAFFASVEQLTRPTLRGRPVlvgGLGGRGVVAGASYEARVFGARSAMPMHQARRLVGNGAVV----LPPrfv 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 130 -FRDTSKILYRVLRSFSwnDRAERLGLDEVFLDvsdmvsynldllnPHGLAnsffclsstdpelgfafDATgfAGCVVAp 208
Cdd:PRK03348 81 vYRAASRRVFDTLRELS--PVVEQLSFDEAFVE-------------PAELA-----------------GAS--AEEVEA- 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 209 swssnssrgvvesdeasgllrkrlllashLAYRIRLRIEQE-GYTSACGISVNKLLAKMVGSRNKPrNQTTLLAlsRADT 287
Cdd:PRK03348 126 -----------------------------FAERLRARVREEtGLPASVGAGSGKQIAKIASGLAKP-DGIRVVP--PGEE 173
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 288 LSFVDQHSLRSLPGIGgsmaAVMEQHTRstapdkplKAGqVRLQHDVSPHLLEKLLQPLGleKGIGQKTYRLLHGID--- 364
Cdd:PRK03348 174 RELLAPLPVRRLWGIG----PVTEEKLH--------RLG-IETIGDLAALSEAEVANLLG--ATVGPALHRLARGIDdrp 238
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 2286886203 365 ---TAEVKfacdfpiQIGIEDTYAnTGLSNIAQITQQLIKLSASLIRRIRVD 413
Cdd:PRK03348 239 vaeRAEAK-------QISAESTFA-VDLTTRAQLREAIERIAEHAHRRLLKD 282
|
|
| PolY_like |
cd03468 |
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ... |
59-163 |
5.47e-05 |
|
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176458 [Multi-domain] Cd Length: 335 Bit Score: 45.84 E-value: 5.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 59 LHFDYdcFYAQVVENKEPSLKSLPVGI---KQKSILATCNYVARRRGVKKLMRISEARDICPDLVLVdgeDLTPFRDTSK 135
Cdd:cd03468 3 LWFPR--LPLDALLRNRPADDEAPLAVverKKAGRILACNAAARAAGVRPGMPLAEALALCPNLQVV---EYDPEADARA 77
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90 100
....*....|....*....|....*...
gi 2286886203 136 ILYRVLRSFSWNDRAERLGLDEVFLDVS 163
Cdd:cd03468 78 LQELALWLLRFTPLVALDGPDGLLLDVT 105
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| PRK03352 |
PRK03352 |
DNA polymerase IV; Validated |
55-308 |
4.90e-04 |
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DNA polymerase IV; Validated
Pssm-ID: 179564 [Multi-domain] Cd Length: 346 Bit Score: 42.70 E-value: 4.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 55 ERIILHFDYDCFYAQVVENKEPSLKSLPVGI-------KQKSILATCNYVARRRGVKKLM--RISEARdiCPDLVLVDgE 125
Cdd:PRK03352 4 PRWVLHVDLDQFIAAVELLRRPELAGLPVIVggngdptEPRKVVTCASYEARAFGVRAGMplRTAARR--CPDAVFLP-S 80
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90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 126 DLTPFRDTSKILYRVLRSFSwnDRAERLGLDEVFLDVsdmvsynldllnphglansffclSSTDPELgfafdatgfagcv 205
Cdd:PRK03352 81 DPAAYDAASEEVMATLRDLG--VPVEVWGWDEAFLGV-----------------------DTDDPEA------------- 122
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170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286886203 206 vapswssnssrgvvesdeasgllrkrlllashLAYRIRLRI-EQEGYTSACGISVNKLLAKMVGSRNKPRNqttLLALSR 284
Cdd:PRK03352 123 --------------------------------LAEEIRAAVlERTGLSCSVGIGDNKLRAKIATGFAKPAG---VFRLTD 167
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250 260
....*....|....*....|....
gi 2286886203 285 ADTLSFVDQHSLRSLPGIGGSMAA 308
Cdd:PRK03352 168 ANWMAVMGDRPTDALWGVGPKTAK 191
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