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Conserved domains on  [gi|2291295425|gb|KAI6989326|]
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hypothetical protein KC359_g7291 [Hortaea werneckii]

Protein Classification

TBP family protein( domain architecture ID 1646)

TBP family protein similar to TATA-box-binding protein (TBP), a general transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID

CATH:  3.30.310.10
Gene Ontology:  GO:0003677|GO:0006352
PubMed:  12878007|11051541|35597524|30710057
SCOP:  4002023

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TBP_TLF super family cl08263
TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription ...
 32-205 6.14e-83

TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA. New members of the TBP family, called TBP-like proteins (TBLP, TLF, TLP) or TBP-related factors (TRF1, TRF2,TRP), are similar to the core domain of TBPs, with identical or chemically similar amino acids at many equivalent positions, suggesting similar structure. However, TLFs contain distinct, conserved amino acids at several positions that distinguish them from TBP.


The actual alignment was detected with superfamily member cd04516:

Pssm-ID: 447593  Cd Length: 174  Bit Score: 243.67  E-value: 6.14e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2291295425  32 PTISNVVAGMDVNCLIDLKTVAMHCRNSLYNPKRFPAVIMRIREPKATGLIFAKGKLQVLGCRSVDDARLAGRKFARILQ 111
Cdd:cd04516     2 PKIQNIVATVNLGCKLDLKKIALRARNAEYNPKRFAAVIMRIREPKTTALIFSSGKMVCTGAKSEDDSKLAARKYARIIQ 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2291295425 112 KTGFTgVKLTDFTVQNMVGNADTKMLIRLEGLQRKCAQYAKYEPELFPGMVFSLADPKMVMLIFAKGKLVFLGAKKEEDM 191
Cdd:cd04516    82 KLGFP-AKFTDFKIQNIVGSCDVKFPIRLEGLAHAHKQFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKSREEI 160

                         170
                  ....*....|....
gi 2291295425 192 REALGKVWPLLLQF 205
Cdd:cd04516   161 YQAFENIYPILLQF 174
 
Name Accession Description Interval E-value
TBP_eukaryotes cd04516
eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are ...
 32-205 6.14e-83

eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA.


Pssm-ID: 239952  Cd Length: 174  Bit Score: 243.67  E-value: 6.14e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2291295425  32 PTISNVVAGMDVNCLIDLKTVAMHCRNSLYNPKRFPAVIMRIREPKATGLIFAKGKLQVLGCRSVDDARLAGRKFARILQ 111
Cdd:cd04516     2 PKIQNIVATVNLGCKLDLKKIALRARNAEYNPKRFAAVIMRIREPKTTALIFSSGKMVCTGAKSEDDSKLAARKYARIIQ 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2291295425 112 KTGFTgVKLTDFTVQNMVGNADTKMLIRLEGLQRKCAQYAKYEPELFPGMVFSLADPKMVMLIFAKGKLVFLGAKKEEDM 191
Cdd:cd04516    82 KLGFP-AKFTDFKIQNIVGSCDVKFPIRLEGLAHAHKQFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKSREEI 160

                         170
                  ....*....|....
gi 2291295425 192 REALGKVWPLLLQF 205
Cdd:cd04516   161 YQAFENIYPILLQF 174
PLN00062 PLN00062
TATA-box-binding protein; Provisional
 32-206 1.40e-77

TATA-box-binding protein; Provisional


Pssm-ID: 177693 [Multi-domain]  Cd Length: 179  Bit Score: 230.35  E-value: 1.40e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2291295425  32 PTISNVVAGMDVNCLIDLKTVAMHCRNSLYNPKRFPAVIMRIREPKATGLIFAKGKLQVLGCRSVDDARLAGRKFARILQ 111
Cdd:PLN00062    2 PTLQNIVSTVNLDCKLDLKKIALQARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVCTGAKSEHDSKLAARKYARIIQ 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2291295425 112 KTGFTgVKLTDFTVQNMVGNADTKMLIRLEGLQRKCAQYAKYEPELFPGMVFSLADPKMVMLIFAKGKLVFLGAKKEEDM 191
Cdd:PLN00062   82 KLGFP-AKFKDFKIQNIVGSCDVKFPIRLEGLAYAHGAFSSYEPELFPGLIYRMKQPKIVLLIFVSGKIVITGAKVREEI 160

                         170
                  ....*....|....*
gi 2291295425 192 REALGKVWPLLLQFR 206
Cdd:PLN00062  161 YTAFENIYPVLTEFR 175
SPT15 COG2101
TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];
32-198 2.53e-48

TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];


Pssm-ID: 441704  Cd Length: 180  Bit Score: 156.13  E-value: 2.53e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2291295425  32 PTISNVVAGMDVNCLIDLKTVAMHCRNSLYNPKRFPAVIMRIREPKATGLIFAKGKLQVLGCRSVDDARLAGRKFARILQ 111
Cdd:COG2101     4 IEIENIVASGSLGQELDLEKLAEDLPNAEYNPEQFPGLVYRLKEPKTAALIFRSGKMVCTGAKSEEDLIEAVEKVIEKLR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2291295425 112 KTGFTGVKLTDFTVQNMVGNADTKMLIRLE------GLQRkcaqyAKYEPELFPGMVFSLADPKMVMLIFAKGKLVFLGA 185
Cdd:COG2101    84 KLGIEIPDEPEITVQNIVASADLGREINLNalaiglGLEN-----IEYEPEQFPGLVYRLDDPKVVLLLFSSGKLVITGA 158

                         170
                  ....*....|...
gi 2291295425 186 KKEEDMREALGKV 198
Cdd:COG2101   159 KDEEEAERAVDKL 171
TBP pfam00352
Transcription factor TFIID (or TATA-binding protein, TBP);
32-112 1.99e-34

Transcription factor TFIID (or TATA-binding protein, TBP);


Pssm-ID: 425630 [Multi-domain]  Cd Length: 84  Bit Score: 117.54  E-value: 1.99e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2291295425  32 PTISNVVAGMDVNCLIDLKTVAM-HCRNSLYNPKRFPAVIMRIREPKATGLIFAKGKLQVLGCRSVDDARLAGRKFARIL 110
Cdd:pfam00352   2 IKIQNVVASADLGFPIDLEKLALkLLENVEYEPERFPGLVYRLREPKVTALIFSSGKIVITGAKSEEDAKKAIRKIAPIL 81


                  ..
gi 2291295425 111 QK 112
Cdd:pfam00352  82 QK 83
 
Name Accession Description Interval E-value
TBP_eukaryotes cd04516
eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are ...
 32-205 6.14e-83

eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA.


Pssm-ID: 239952  Cd Length: 174  Bit Score: 243.67  E-value: 6.14e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2291295425  32 PTISNVVAGMDVNCLIDLKTVAMHCRNSLYNPKRFPAVIMRIREPKATGLIFAKGKLQVLGCRSVDDARLAGRKFARILQ 111
Cdd:cd04516     2 PKIQNIVATVNLGCKLDLKKIALRARNAEYNPKRFAAVIMRIREPKTTALIFSSGKMVCTGAKSEDDSKLAARKYARIIQ 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2291295425 112 KTGFTgVKLTDFTVQNMVGNADTKMLIRLEGLQRKCAQYAKYEPELFPGMVFSLADPKMVMLIFAKGKLVFLGAKKEEDM 191
Cdd:cd04516    82 KLGFP-AKFTDFKIQNIVGSCDVKFPIRLEGLAHAHKQFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKSREEI 160

                         170
                  ....*....|....
gi 2291295425 192 REALGKVWPLLLQF 205
Cdd:cd04516   161 YQAFENIYPILLQF 174
TBP_TLF cd00652
TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription ...
 32-204 3.22e-79

TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA. New members of the TBP family, called TBP-like proteins (TBLP, TLF, TLP) or TBP-related factors (TRF1, TRF2,TRP), are similar to the core domain of TBPs, with identical or chemically similar amino acids at many equivalent positions, suggesting similar structure. However, TLFs contain distinct, conserved amino acids at several positions that distinguish them from TBP.


Pssm-ID: 238352 [Multi-domain]  Cd Length: 174  Bit Score: 234.36  E-value: 3.22e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2291295425  32 PTISNVVAGMDVNCLIDLKTVAMHCRNSLYNPKRFPAVIMRIREPKATGLIFAKGKLQVLGCRSVDDARLAGRKFARILQ 111
Cdd:cd00652     2 PKIQNIVATVNLGCELDLRKIALAARNAEYNPKRFPGVIMRLREPKTTALIFSSGKMVITGAKSEEDAKLAARKYARILQ 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2291295425 112 KTGFTGVKLTDFTVQNMVGNADTKMLIRLEGLQRKCAQYAKYEPELFPGMVFSLADPKMVMLIFAKGKLVFLGAKKEEDM 191
Cdd:cd00652    82 KLGFPVEKFPEFKVQNIVASCDLGFPIRLEELALKHPENASYEPELFPGLIYRMDEPKVVLLIFVSGKIVITGAKSREDI 161

                         170
                  ....*....|...
gi 2291295425 192 REALGKVWPLLLQ 204
Cdd:cd00652   162 YEAVEKIYPILKE 174
PLN00062 PLN00062
TATA-box-binding protein; Provisional
 32-206 1.40e-77

TATA-box-binding protein; Provisional


Pssm-ID: 177693 [Multi-domain]  Cd Length: 179  Bit Score: 230.35  E-value: 1.40e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2291295425  32 PTISNVVAGMDVNCLIDLKTVAMHCRNSLYNPKRFPAVIMRIREPKATGLIFAKGKLQVLGCRSVDDARLAGRKFARILQ 111
Cdd:PLN00062    2 PTLQNIVSTVNLDCKLDLKKIALQARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVCTGAKSEHDSKLAARKYARIIQ 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2291295425 112 KTGFTgVKLTDFTVQNMVGNADTKMLIRLEGLQRKCAQYAKYEPELFPGMVFSLADPKMVMLIFAKGKLVFLGAKKEEDM 191
Cdd:PLN00062   82 KLGFP-AKFKDFKIQNIVGSCDVKFPIRLEGLAYAHGAFSSYEPELFPGLIYRMKQPKIVLLIFVSGKIVITGAKVREEI 160

                         170
                  ....*....|....*
gi 2291295425 192 REALGKVWPLLLQFR 206
Cdd:PLN00062  161 YTAFENIYPVLTEFR 175
PRK00394 PRK00394
transcription factor; Reviewed
 33-198 2.67e-49

transcription factor; Reviewed


Pssm-ID: 234746  Cd Length: 179  Bit Score: 158.47  E-value: 2.67e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2291295425  33 TISNVVAGMDVNCLIDLKTVAMHCRNSLYNPKRFPAVIMRIREPKATGLIFAKGKLQVLGCRSVDDARLAGRKFARILQK 112
Cdd:PRK00394    2 KIENIVASTDLGQELDLEKVAEDLPNAEYNPEQFPGLVYRLEDPKIAALIFRSGKVVCTGAKSVEDLHEAVKIIIKKLKE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2291295425 113 TGFTGVKLTDFTVQNMVGNADTKMLIRLE----GLQRKCAQyakYEPELFPGMVFSLADPKMVMLIFAKGKLVFLGAKKE 188
Cdd:PRK00394   82 LGIKVIDEPEIKVQNIVASADLGVELNLNaiaiGLGLENIE---YEPEQFPGLVYRLDDPKVVVLLFGSGKLVITGAKSE 158

                         170
                  ....*....|
gi 2291295425 189 EDMREALGKV 198
Cdd:PRK00394  159 EDAEKAVEKI 168
SPT15 COG2101
TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];
32-198 2.53e-48

TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];


Pssm-ID: 441704  Cd Length: 180  Bit Score: 156.13  E-value: 2.53e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2291295425  32 PTISNVVAGMDVNCLIDLKTVAMHCRNSLYNPKRFPAVIMRIREPKATGLIFAKGKLQVLGCRSVDDARLAGRKFARILQ 111
Cdd:COG2101     4 IEIENIVASGSLGQELDLEKLAEDLPNAEYNPEQFPGLVYRLKEPKTAALIFRSGKMVCTGAKSEEDLIEAVEKVIEKLR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2291295425 112 KTGFTGVKLTDFTVQNMVGNADTKMLIRLE------GLQRkcaqyAKYEPELFPGMVFSLADPKMVMLIFAKGKLVFLGA 185
Cdd:COG2101    84 KLGIEIPDEPEITVQNIVASADLGREINLNalaiglGLEN-----IEYEPEQFPGLVYRLDDPKVVLLLFSSGKLVITGA 158

                         170
                  ....*....|...
gi 2291295425 186 KKEEDMREALGKV 198
Cdd:COG2101   159 KDEEEAERAVDKL 171
TLF cd04517
TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and ...
 32-204 3.17e-48

TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the basal transcription machinery. Yet, in contrast to TBPs, TLFs seem not to interact with the TATA-box and even have a negative effect on the transcription of TATA-containing promoters. Recent results indicate that TLFs are involved in the transcription via TATA-less promoters.


Pssm-ID: 239953  Cd Length: 174  Bit Score: 155.57  E-value: 3.17e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2291295425  32 PTISNVVAGMDVNCLIDLKTVAMHCRNSLYNPkRFPAVIMRIREPKATGLIFAKGKLQVLGCRSVDDARLAGRKFARILQ 111
Cdd:cd04517     3 ILIVNVVCQFSLRCHIDLRKLALAGRNVEYNP-RYPKVTMRLREPRATASVWSSGKITITGATSEEEAKQAARRAARLLQ 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2291295425 112 KTGFTGVKLTDFTVQNMVGNADTKMLIRLEGLQRKCAQYAKYEPELFPGMVFSLADPKMVMLIFAKGKLVFLGAKKEEDM 191
Cdd:cd04517    82 KLGFKVVRFSNFRVVNVLATCSMPFPIRLDELAAKNRSSASYEPELHPGVVYRITGPRATLSIFSTGSVTVTGARSMEDV 161

                         170
                  ....*....|...
gi 2291295425 192 REALGKVWPLLLQ 204
Cdd:cd04517   162 REAVEKIYPIVFE 174
TBP_archaea cd04518
archaeal TATA box binding protein (TBP): TBPs are transcription factors present in archaea and ...
 32-198 2.07e-45

archaeal TATA box binding protein (TBP): TBPs are transcription factors present in archaea and eukaryotes, that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA.


Pssm-ID: 239954  Cd Length: 174  Bit Score: 148.55  E-value: 2.07e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2291295425  32 PTISNVVAGMDVNCLIDLKTVAMHCRNSLYNPKRFPAVIMRIREPKATGLIFAKGKLQVLGCRSVDDARLAGRKFARILQ 111
Cdd:cd04518     2 LKIENIVASVDLGQELDLEKVAAELPNAEYNPDQFPGLVYRLEDPKIAALIFRSGKMVCTGAKSVEDLHRAVKEIIKKLK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2291295425 112 KTGFTGVKLTDFTVQNMVGNAD-------TKMLIRLEGlqrkcaqyAKYEPELFPGMVFSLADPKMVMLIFAKGKLVFLG 184
Cdd:cd04518    82 DYGIKVIEKPEIKVQNIVASADlgrevnlDAIAIGLPN--------AEYEPEQFPGLVYRLDEPKVVLLLFSSGKMVITG 153

                         170
                  ....*....|....
gi 2291295425 185 AKKEEDMREALGKV 198
Cdd:cd04518   154 AKSEEDAKRAVEKL 167
TBP pfam00352
Transcription factor TFIID (or TATA-binding protein, TBP);
32-112 1.99e-34

Transcription factor TFIID (or TATA-binding protein, TBP);


Pssm-ID: 425630 [Multi-domain]  Cd Length: 84  Bit Score: 117.54  E-value: 1.99e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2291295425  32 PTISNVVAGMDVNCLIDLKTVAM-HCRNSLYNPKRFPAVIMRIREPKATGLIFAKGKLQVLGCRSVDDARLAGRKFARIL 110
Cdd:pfam00352   2 IKIQNVVASADLGFPIDLEKLALkLLENVEYEPERFPGLVYRLREPKVTALIFSSGKIVITGAKSEEDAKKAIRKIAPIL 81


                  ..
gi 2291295425 111 QK 112
Cdd:pfam00352  82 QK 83
TBP pfam00352
Transcription factor TFIID (or TATA-binding protein, TBP);
122-205 8.99e-28

Transcription factor TFIID (or TATA-binding protein, TBP);


Pssm-ID: 425630 [Multi-domain]  Cd Length: 84  Bit Score: 100.20  E-value: 8.99e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2291295425 122 DFTVQNMVGNADTKMLIRLEGLQRKCAQYAKYEPELFPGMVFSLADPKMVMLIFAKGKLVFLGAKKEEDMREALGKVWPL 201
Cdd:pfam00352   1 DIKIQNVVASADLGFPIDLEKLALKLLENVEYEPERFPGLVYRLREPKVTALIFSSGKIVITGAKSEEDAKKAIRKIAPI 80


                  ....
gi 2291295425 202 LLQF 205
Cdd:pfam00352  81 LQKL 84
SPT15 COG2101
TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];
32-115 5.48e-15

TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];


Pssm-ID: 441704  Cd Length: 180  Bit Score: 69.84  E-value: 5.48e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2291295425  32 PTISNVVAGMDVNCLIDLKTVAMHCR--NSLYNPKRFPAVIMRIREPKATGLIFAKGKLQVLGCRSVDDARLAGRKFARI 109
Cdd:COG2101    95 ITVQNIVASADLGREINLNALAIGLGleNIEYEPEQFPGLVYRLDDPKVVLLLFSSGKLVITGAKDEEEAERAVDKLRER 174


                  ....*.
gi 2291295425 110 LQKTGF 115
Cdd:COG2101   175 LEELGL 180
TBP_archaea cd04518
archaeal TATA box binding protein (TBP): TBPs are transcription factors present in archaea and ...
 30-112 1.05e-14

archaeal TATA box binding protein (TBP): TBPs are transcription factors present in archaea and eukaryotes, that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA.


Pssm-ID: 239954  Cd Length: 174  Bit Score: 68.81  E-value: 1.05e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2291295425  30 TGPTISNVVAGMDVNCLIDLKTVAMHCRNSLYNPKRFPAVIMRIREPKATGLIFAKGKLQVLGCRSVDDARLAGRKFARI 109
Cdd:cd04518    91 PEIKVQNIVASADLGREVNLDAIAIGLPNAEYEPEQFPGLVYRLDEPKVVLLLFSSGKMVITGAKSEEDAKRAVEKLLSR 170


                  ...
gi 2291295425 110 LQK 112
Cdd:cd04518   171 LKE 173
PRK00394 PRK00394
transcription factor; Reviewed
 33-114 1.07e-14

transcription factor; Reviewed


Pssm-ID: 234746  Cd Length: 179  Bit Score: 69.11  E-value: 1.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2291295425  33 TISNVVAGMDVNCLIDLKTVAMH--CRNSLYNPKRFPAVIMRIREPKATGLIFAKGKLQVLGCRSVDDARLAGRKFARIL 110
Cdd:PRK00394   93 KVQNIVASADLGVELNLNAIAIGlgLENIEYEPEQFPGLVYRLDDPKVVVLLFGSGKLVITGAKSEEDAEKAVEKILEKL 172


                  ....
gi 2291295425 111 QKTG 114
Cdd:PRK00394  173 EELG 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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