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Conserved domains on  [gi|2431900630|gb|KAJ4622502|]
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Salivary acidic proline-rich phosphoprotein 1/2 [Exophiala dermatitidis]

Protein Classification

ATP-dependent RNA helicase( domain architecture ID 13388279)

DEAD/DEAH box containing ATP-dependent RNA helicase catalyzes the unwinding of RNA, similar to DEAH box protein 34 (DHX34) that is required for nonsense-mediated decay (NMD) degradation of mRNA transcripts containing premature stop codons

CATH:  3.40.50.300
EC:  3.6.4.13
Gene Ontology:  GO:0005524|GO:0003724|GO:0003676|GO:0016887|GO:0003723
PubMed:  34680866|19747077|22922795|20206133|21779027|20225155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HrpA super family cl34328
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
127-666 5.07e-159

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG1643:

Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 486.90  E-value: 5.07e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 127 LLSTRQQLPIYSHADHIRQNLREHDVLLLVGETGSGKSTQIPQFLVNEAWCRRQKtkgkgsvggcIAITQPRRVAAISLA 206
Cdd:COG1643     3 LITYPPDLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWGAGGR----------IGMLEPRRLAARAAA 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 207 RRVAEEMGTPLGNsspasQVGYSVRFENSTSPSTRIKFLTEGMLLQEMLRDPWLKEYSAVVVDEVHERGVNVDLVLGFLR 286
Cdd:COG1643    73 ERMAEELGEPVGE-----TVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLL 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 287 rmhDLRSK--DDgrggvpMKVVVMSATADMEKISGFFNGqqqqllqpeqgvdksieekkaslkdkaadatktlavngakt 364
Cdd:COG1643   148 ---DLQPAlrPD------LKLLVMSATLDAERFARLLGD----------------------------------------- 177

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 365 esqkqksqhrATSLFIKGRQHPVTINYTP--SPVPDILDAAYERIMHIHSHSPlpGDILVFLTGQ----ETVESLMSlvt 438
Cdd:COG1643   178 ----------APVIESSGRTYPVEVRYRPlpADERDLEDAVADAVREALAEEP--GDILVFLPGEreirRTAEALRG--- 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 439 nwatsiqkdpklsRQLPKLLVLPLYAALPSHMQQRVFQPTPKFTRKIILATNIAETSITVPGVRYVIDTGKAKQRLFRPS 518
Cdd:COG1643   243 -------------RLPPDTEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPR 309

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 519 LNLDTLLTVPISRSSANQRSGRAGRDAPGTAYRLYTESDFYRLPQDTEPEILRCDLSQLVLTLKAHGIDDLLGFPFLTSP 598
Cdd:COG1643   310 SGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDLPFLDPP 389

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2431900630 599 PRRALERAMIHLVQLTALDtTTGKITPLGRDMSGLPLPASLARVLLASAepEFDCVDEIVDIVSALSV 666
Cdd:COG1643   390 PARAIADARALLQELGALD-ADGRLTPLGRALARLPLDPRLARMLLAAA--ELGCLREAAILAALLSE 454
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 818-898 5.29e-18

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


:

Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 79.22  E-value: 5.29e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 818 ILKCILTGFHANVARLSPDG-SYRTVLTNQPVAIHPSSVLFSAGGgggggpKKFEGIVYNEFVYTgTKAYARGVSAVEMR 896
Cdd:pfam07717   1 LRAALAAGLYPNVARRDPKGkGYTTLSDNQRVFIHPSSVLFNEKT------FPPEWVVYQELVET-TKVYIRTVTAISPE 73


                  ..
gi 2431900630 897 WL 898
Cdd:pfam07717  74 WL 75
 
Name Accession Description Interval E-value
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
127-666 5.07e-159

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 486.90  E-value: 5.07e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 127 LLSTRQQLPIYSHADHIRQNLREHDVLLLVGETGSGKSTQIPQFLVNEAWCRRQKtkgkgsvggcIAITQPRRVAAISLA 206
Cdd:COG1643     3 LITYPPDLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWGAGGR----------IGMLEPRRLAARAAA 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 207 RRVAEEMGTPLGNsspasQVGYSVRFENSTSPSTRIKFLTEGMLLQEMLRDPWLKEYSAVVVDEVHERGVNVDLVLGFLR 286
Cdd:COG1643    73 ERMAEELGEPVGE-----TVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLL 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 287 rmhDLRSK--DDgrggvpMKVVVMSATADMEKISGFFNGqqqqllqpeqgvdksieekkaslkdkaadatktlavngakt 364
Cdd:COG1643   148 ---DLQPAlrPD------LKLLVMSATLDAERFARLLGD----------------------------------------- 177

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 365 esqkqksqhrATSLFIKGRQHPVTINYTP--SPVPDILDAAYERIMHIHSHSPlpGDILVFLTGQ----ETVESLMSlvt 438
Cdd:COG1643   178 ----------APVIESSGRTYPVEVRYRPlpADERDLEDAVADAVREALAEEP--GDILVFLPGEreirRTAEALRG--- 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 439 nwatsiqkdpklsRQLPKLLVLPLYAALPSHMQQRVFQPTPKFTRKIILATNIAETSITVPGVRYVIDTGKAKQRLFRPS 518
Cdd:COG1643   243 -------------RLPPDTEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPR 309

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 519 LNLDTLLTVPISRSSANQRSGRAGRDAPGTAYRLYTESDFYRLPQDTEPEILRCDLSQLVLTLKAHGIDDLLGFPFLTSP 598
Cdd:COG1643   310 SGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDLPFLDPP 389

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2431900630 599 PRRALERAMIHLVQLTALDtTTGKITPLGRDMSGLPLPASLARVLLASAepEFDCVDEIVDIVSALSV 666
Cdd:COG1643   390 PARAIADARALLQELGALD-ADGRLTPLGRALARLPLDPRLARMLLAAA--ELGCLREAAILAALLSE 454
DEAH_box_HrpA TIGR01967
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ...
 120-669 1.76e-107

RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273900 [Multi-domain]  Cd Length: 1283  Bit Score: 360.62  E-value: 1.76e-107
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630  120 LKERARQLLSTRQQLPIYSHADHIRQNLREHDVLLLVGETGSGKSTQIPQFLVNeawcrrqktKGKGSvGGCIAITQPRR 199
Cdd:TIGR01967   52 ARRQAVPEIRYPDNLPVSAKREDIAEAIAENQVVIIAGETGSGKTTQLPKICLE---------LGRGS-HGLIGHTQPRR 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630  200 VAAISLARRVAEEMGTPLGnsspaSQVGYSVRFENSTSPSTRIKFLTEGMLLQEMLRDPWLKEYSAVVVDEVHERGVNVD 279
Cdd:TIGR01967  122 LAARTVAQRIAEELGTPLG-----EKVGYKVRFHDQVSSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERSLNID 196

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630  280 LVLGFLRRMhdLRSKDDgrggvpMKVVVMSATADMEKISGFFNGqqqqllqpeqgvdksieekkaslkdkaadatktlav 359
Cdd:TIGR01967  197 FLLGYLKQL--LPRRPD------LKIIITSATIDPERFSRHFNN------------------------------------ 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630  360 ngaktesqkqksqhrATSLFIKGRQHPVTINYTP----------SPVPDILDAAYERIMHihshspLPGDILVFLTGQET 429
Cdd:TIGR01967  233 ---------------APIIEVSGRTYPVEVRYRPlveeqedddlDQLEAILDAVDELFAE------GPGDILIFLPGERE 291

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630  430 VESLMSLVTNwatsiqkdpklsRQLPKLLVLPLYAALPSHMQQRVFQPTPKftRKIILATNIAETSITVPGVRYVIDTGK 509
Cdd:TIGR01967  292 IRDAAEILRK------------RNLRHTEILPLYARLSNKEQQRVFQPHSG--RRIVLATNVAETSLTVPGIHYVIDTGT 357

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630  510 AKQRLFRPSLNLDTLLTVPISRSSANQRSGRAGRDAPGTAYRLYTESDFYRLPQDTEPEILRCDLSQLVLTLKAHGIDDL 589
Cdd:TIGR01967  358 ARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNSRPEFTDPEILRTNLASVILQMLALRLGDI 437

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630  590 LGFPFLTSPPRRALERAMIHLVQLTALDTTTG--KITPLGRDMSGLPLPASLARVLLASAepEFDCVDEIVDIVSALSVE 667
Cdd:TIGR01967  438 AAFPFIEAPDPRAIRDGFRLLEELGALDDDEAepQLTPIGRQLAQLPVDPRLARMLLEAH--RLGCLQEVLIIASALSIQ 515


                   ..
gi 2431900630  668 NV 669
Cdd:TIGR01967  516 DP 517
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 108-668 7.07e-101

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 342.42  E-value: 7.07e-101
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630  108 QTTQQLNNRhsnlkERARQLLSTRQQLPIYSHADHIRQNLREHDVLLLVGETGSGKSTQIPQFLVneawcrrqkTKGKGs 187
Cdd:PRK11131    52 QAAQRVLLR-----EAARPEITYPENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICL---------ELGRG- 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630  188 VGGCIAITQPRRVAAISLARRVAEEMGTPLGnsspaSQVGYSVRFENSTSPSTRIKFLTEGMLLQEMLRDPWLKEYSAVV 267
Cdd:PRK11131   117 VKGLIGHTQPRRLAARTVANRIAEELETELG-----GCVGYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTII 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630  268 VDEVHERGVNVDLVLGFLRRMhdLRSKDDgrggvpMKVVVMSATADMEKISGFFNGQQQqllqpeqgvdksIEekkaslk 347
Cdd:PRK11131   192 IDEAHERSLNIDFILGYLKEL--LPRRPD------LKVIITSATIDPERFSRHFNNAPI------------IE------- 244

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630  348 dkaadatktlavngaktesqkqksqhratslfIKGRQHPVTINYTP------SPVPDILDAAYERIMHIHSHSPlpGDIL 421
Cdd:PRK11131   245 --------------------------------VSGRTYPVEVRYRPiveeadDTERDQLQAIFDAVDELGREGP--GDIL 290

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630  422 VFLTGQETVEslmslvtNWATSIQKdpklsRQLPKLLVLPLYAALPSHMQQRVFQPTPkfTRKIILATNIAETSITVPGV 501
Cdd:PRK11131   291 IFMSGEREIR-------DTADALNK-----LNLRHTEILPLYARLSNSEQNRVFQSHS--GRRIVLATNVAETSLTVPGI 356

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630  502 RYVIDTGKAkqRLFRPSL--NLDTLLTVPISRSSANQRSGRAGRDAPGTAYRLYTESDFYRLPQDTEPEILRCDLSQLVL 579
Cdd:PRK11131   357 KYVIDPGTA--RISRYSYrtKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVIL 434

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630  580 TLKAHGIDDLLGFPFLTSPPRRALERAMIHLVQLTALDTTTG----KITPLGRDMSGLPLPASLARVLLASaePEFDCVD 655
Cdd:PRK11131   435 QMTALGLGDIAAFPFVEAPDKRNIQDGVRLLEELGAITTDEQasayKLTPLGRQLAQLPVDPRLARMVLEA--QKHGCVR 512

                          570
                   ....*....|...
gi 2431900630  656 EIVDIVSALSVEN 668
Cdd:PRK11131   513 EVMIITSALSIQD 525
DEXHc_RHA-like cd17917
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ...
 150-323 1.55e-74

DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438707 [Multi-domain]  Cd Length: 159  Bit Score: 240.82  E-value: 1.55e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 150 HDVLLLVGETGSGKSTQIPQFLVNEAWCRRQKtkgkgsvgGCIAITQPRRVAAISLARRVAEEMGTPLGNSspasqVGYS 229
Cdd:cd17917     1 NQVVVIVGETGSGKTTQVPQFLLEDGLAKGGK--------GRIVCTQPRRIAAISVAERVAEERGEKLGEE-----VGYQ 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 230 VRFENSTSPSTRIKFLTEGMLLQEMLRDPWLKEYSAVVVDEVHERGVNVDLVLGFLRRMhdLRSKDDgrggvpMKVVVMS 309
Cdd:cd17917    68 IRFESKTSSKTRIKFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDL--LRKRPD------LKVILMS 139

                         170
                  ....*....|....
gi 2431900630 310 ATADMEKISGFFNG 323
Cdd:cd17917   140 ATLDAEKFSSYFGG 153
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 606-727 2.78e-22

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 92.30  E-value: 2.78e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 606 AMIHLVQLTALDTTtGKITPLGRDMSGLPLPASLARVLLASAepEFDCVDEIVDIVSALSVENVFLNIHRNQSDGLQNDN 685
Cdd:pfam04408   1 ALELLYYLGALDED-GELTPLGRKMAELPLDPRLAKMLLAAA--ELGCLDEVLTIVAALSVRDPFVQPNFLDPRSAAKAA 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2431900630 686 NRRGEGDGDGDVDADAENEtrearaeryrrvlfrREGDHLTL 727
Cdd:pfam04408  78 RRRRRAADEKARAKFARLD---------------LEGDHLTL 104
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 818-898 5.29e-18

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 79.22  E-value: 5.29e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 818 ILKCILTGFHANVARLSPDG-SYRTVLTNQPVAIHPSSVLFSAGGgggggpKKFEGIVYNEFVYTgTKAYARGVSAVEMR 896
Cdd:pfam07717   1 LRAALAAGLYPNVARRDPKGkGYTTLSDNQRVFIHPSSVLFNEKT------FPPEWVVYQELVET-TKVYIRTVTAISPE 73


                  ..
gi 2431900630 897 WL 898
Cdd:pfam07717  74 WL 75
DEXDc smart00487
DEAD-like helicases superfamily;
147-312 1.14e-16

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 79.46  E-value: 1.14e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630  147 LREHDVLLLVGETGSGKSTQIPQFLVNeawcrrqktKGKGSVGGCIAITQPRRVAAISLARRVAEEMGtPLGNSSPASQV 226
Cdd:smart00487  21 LSGLRDVILAAPTGSGKTLAALLPALE---------ALKRGKGGRVLVLVPTRELAEQWAEELKKLGP-SLGLKVVGLYG 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630  227 GYSVR--FENSTSPSTRIKFLTEGMLLQEMLRDP-WLKEYSAVVVDEVHERGVNV--DLVLGFLRRMHDLRskddgrggv 301
Cdd:smart00487  91 GDSKReqLRKLESGKTDILVTTPGRLLDLLENDKlSLSNVDLVILDEAHRLLDGGfgDQLEKLLKLLPKNV--------- 161

                          170
                   ....*....|.
gi 2431900630  302 pmKVVVMSATA 312
Cdd:smart00487 162 --QLLLLSATP 170
 
Name Accession Description Interval E-value
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
127-666 5.07e-159

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 486.90  E-value: 5.07e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 127 LLSTRQQLPIYSHADHIRQNLREHDVLLLVGETGSGKSTQIPQFLVNEAWCRRQKtkgkgsvggcIAITQPRRVAAISLA 206
Cdd:COG1643     3 LITYPPDLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWGAGGR----------IGMLEPRRLAARAAA 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 207 RRVAEEMGTPLGNsspasQVGYSVRFENSTSPSTRIKFLTEGMLLQEMLRDPWLKEYSAVVVDEVHERGVNVDLVLGFLR 286
Cdd:COG1643    73 ERMAEELGEPVGE-----TVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLL 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 287 rmhDLRSK--DDgrggvpMKVVVMSATADMEKISGFFNGqqqqllqpeqgvdksieekkaslkdkaadatktlavngakt 364
Cdd:COG1643   148 ---DLQPAlrPD------LKLLVMSATLDAERFARLLGD----------------------------------------- 177

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 365 esqkqksqhrATSLFIKGRQHPVTINYTP--SPVPDILDAAYERIMHIHSHSPlpGDILVFLTGQ----ETVESLMSlvt 438
Cdd:COG1643   178 ----------APVIESSGRTYPVEVRYRPlpADERDLEDAVADAVREALAEEP--GDILVFLPGEreirRTAEALRG--- 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 439 nwatsiqkdpklsRQLPKLLVLPLYAALPSHMQQRVFQPTPKFTRKIILATNIAETSITVPGVRYVIDTGKAKQRLFRPS 518
Cdd:COG1643   243 -------------RLPPDTEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPR 309

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 519 LNLDTLLTVPISRSSANQRSGRAGRDAPGTAYRLYTESDFYRLPQDTEPEILRCDLSQLVLTLKAHGIDDLLGFPFLTSP 598
Cdd:COG1643   310 SGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDLPFLDPP 389

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2431900630 599 PRRALERAMIHLVQLTALDtTTGKITPLGRDMSGLPLPASLARVLLASAepEFDCVDEIVDIVSALSV 666
Cdd:COG1643   390 PARAIADARALLQELGALD-ADGRLTPLGRALARLPLDPRLARMLLAAA--ELGCLREAAILAALLSE 454
DEAH_box_HrpA TIGR01967
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ...
 120-669 1.76e-107

RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273900 [Multi-domain]  Cd Length: 1283  Bit Score: 360.62  E-value: 1.76e-107
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630  120 LKERARQLLSTRQQLPIYSHADHIRQNLREHDVLLLVGETGSGKSTQIPQFLVNeawcrrqktKGKGSvGGCIAITQPRR 199
Cdd:TIGR01967   52 ARRQAVPEIRYPDNLPVSAKREDIAEAIAENQVVIIAGETGSGKTTQLPKICLE---------LGRGS-HGLIGHTQPRR 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630  200 VAAISLARRVAEEMGTPLGnsspaSQVGYSVRFENSTSPSTRIKFLTEGMLLQEMLRDPWLKEYSAVVVDEVHERGVNVD 279
Cdd:TIGR01967  122 LAARTVAQRIAEELGTPLG-----EKVGYKVRFHDQVSSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERSLNID 196

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630  280 LVLGFLRRMhdLRSKDDgrggvpMKVVVMSATADMEKISGFFNGqqqqllqpeqgvdksieekkaslkdkaadatktlav 359
Cdd:TIGR01967  197 FLLGYLKQL--LPRRPD------LKIIITSATIDPERFSRHFNN------------------------------------ 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630  360 ngaktesqkqksqhrATSLFIKGRQHPVTINYTP----------SPVPDILDAAYERIMHihshspLPGDILVFLTGQET 429
Cdd:TIGR01967  233 ---------------APIIEVSGRTYPVEVRYRPlveeqedddlDQLEAILDAVDELFAE------GPGDILIFLPGERE 291

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630  430 VESLMSLVTNwatsiqkdpklsRQLPKLLVLPLYAALPSHMQQRVFQPTPKftRKIILATNIAETSITVPGVRYVIDTGK 509
Cdd:TIGR01967  292 IRDAAEILRK------------RNLRHTEILPLYARLSNKEQQRVFQPHSG--RRIVLATNVAETSLTVPGIHYVIDTGT 357

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630  510 AKQRLFRPSLNLDTLLTVPISRSSANQRSGRAGRDAPGTAYRLYTESDFYRLPQDTEPEILRCDLSQLVLTLKAHGIDDL 589
Cdd:TIGR01967  358 ARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNSRPEFTDPEILRTNLASVILQMLALRLGDI 437

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630  590 LGFPFLTSPPRRALERAMIHLVQLTALDTTTG--KITPLGRDMSGLPLPASLARVLLASAepEFDCVDEIVDIVSALSVE 667
Cdd:TIGR01967  438 AAFPFIEAPDPRAIRDGFRLLEELGALDDDEAepQLTPIGRQLAQLPVDPRLARMLLEAH--RLGCLQEVLIIASALSIQ 515


                   ..
gi 2431900630  668 NV 669
Cdd:TIGR01967  516 DP 517
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 108-668 7.07e-101

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 342.42  E-value: 7.07e-101
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630  108 QTTQQLNNRhsnlkERARQLLSTRQQLPIYSHADHIRQNLREHDVLLLVGETGSGKSTQIPQFLVneawcrrqkTKGKGs 187
Cdd:PRK11131    52 QAAQRVLLR-----EAARPEITYPENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICL---------ELGRG- 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630  188 VGGCIAITQPRRVAAISLARRVAEEMGTPLGnsspaSQVGYSVRFENSTSPSTRIKFLTEGMLLQEMLRDPWLKEYSAVV 267
Cdd:PRK11131   117 VKGLIGHTQPRRLAARTVANRIAEELETELG-----GCVGYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTII 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630  268 VDEVHERGVNVDLVLGFLRRMhdLRSKDDgrggvpMKVVVMSATADMEKISGFFNGQQQqllqpeqgvdksIEekkaslk 347
Cdd:PRK11131   192 IDEAHERSLNIDFILGYLKEL--LPRRPD------LKVIITSATIDPERFSRHFNNAPI------------IE------- 244

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630  348 dkaadatktlavngaktesqkqksqhratslfIKGRQHPVTINYTP------SPVPDILDAAYERIMHIHSHSPlpGDIL 421
Cdd:PRK11131   245 --------------------------------VSGRTYPVEVRYRPiveeadDTERDQLQAIFDAVDELGREGP--GDIL 290

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630  422 VFLTGQETVEslmslvtNWATSIQKdpklsRQLPKLLVLPLYAALPSHMQQRVFQPTPkfTRKIILATNIAETSITVPGV 501
Cdd:PRK11131   291 IFMSGEREIR-------DTADALNK-----LNLRHTEILPLYARLSNSEQNRVFQSHS--GRRIVLATNVAETSLTVPGI 356

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630  502 RYVIDTGKAkqRLFRPSL--NLDTLLTVPISRSSANQRSGRAGRDAPGTAYRLYTESDFYRLPQDTEPEILRCDLSQLVL 579
Cdd:PRK11131   357 KYVIDPGTA--RISRYSYrtKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVIL 434

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630  580 TLKAHGIDDLLGFPFLTSPPRRALERAMIHLVQLTALDTTTG----KITPLGRDMSGLPLPASLARVLLASaePEFDCVD 655
Cdd:PRK11131   435 QMTALGLGDIAAFPFVEAPDKRNIQDGVRLLEELGAITTDEQasayKLTPLGRQLAQLPVDPRLARMVLEA--QKHGCVR 512

                          570
                   ....*....|...
gi 2431900630  656 EIVDIVSALSVEN 668
Cdd:PRK11131   513 EVMIITSALSIQD 525
DEXHc_RHA-like cd17917
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ...
 150-323 1.55e-74

DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438707 [Multi-domain]  Cd Length: 159  Bit Score: 240.82  E-value: 1.55e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 150 HDVLLLVGETGSGKSTQIPQFLVNEAWCRRQKtkgkgsvgGCIAITQPRRVAAISLARRVAEEMGTPLGNSspasqVGYS 229
Cdd:cd17917     1 NQVVVIVGETGSGKTTQVPQFLLEDGLAKGGK--------GRIVCTQPRRIAAISVAERVAEERGEKLGEE-----VGYQ 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 230 VRFENSTSPSTRIKFLTEGMLLQEMLRDPWLKEYSAVVVDEVHERGVNVDLVLGFLRRMhdLRSKDDgrggvpMKVVVMS 309
Cdd:cd17917    68 IRFESKTSSKTRIKFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDL--LRKRPD------LKVILMS 139

                         170
                  ....*....|....
gi 2431900630 310 ATADMEKISGFFNG 323
Cdd:cd17917   140 ATLDAEKFSSYFGG 153
PRK11664 PRK11664
ATP-dependent RNA helicase HrpB; Provisional
 133-648 1.01e-73

ATP-dependent RNA helicase HrpB; Provisional


Pssm-ID: 236950 [Multi-domain]  Cd Length: 812  Bit Score: 258.70  E-value: 1.01e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 133 QLPIYSHADHIRQNLREHDVLLLVGETGSGKSTQIP-QFLVNeawcrrqktkgkGSVGGCIAITQPRRVAAISLARRVAE 211
Cdd:PRK11664    3 SLPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPlQLLQH------------GGINGKIIMLEPRRLAARNVAQRLAE 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 212 EMGTPLGnsspaSQVGYSVRFENSTSPSTRIKFLTEGMLLQEMLRDPWLKEYSAVVVDEVHERGVNVDLVLGFLRRMHD- 290
Cdd:PRK11664   71 QLGEKPG-----ETVGYRMRAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVQQg 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 291 LRskDDgrggvpMKVVVMSATADmekisgffngqqqqllqpeqgvdksieekkaslkdkaADATKTLAVNGAKTESQkqk 370
Cdd:PRK11664  146 LR--DD------LKLLIMSATLD-------------------------------------NDRLQQLLPDAPVIVSE--- 177

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 371 sqhratslfikGRQHPVTINYTPSPVPDILDAAYER-IMHIHSHSPlpGDILVFLTGQETVESLMSLvtnwatsiqkdpk 449
Cdd:PRK11664  178 -----------GRSFPVERRYQPLPAHQRFDEAVARaTAELLRQES--GSLLLFLPGVGEIQRVQEQ------------- 231

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 450 LSRQLPK-LLVLPLYAALPSHMQQRVFQPTPKFTRKIILATNIAETSITVPGVRYVIDTGKAKQRLFRPSLNLDTLLTVP 528
Cdd:PRK11664  232 LASRVASdVLLCPLYGALSLAEQQKAILPAPAGRRKVVLATNIAETSLTIEGIRLVVDSGLERVARFDPKTGLTRLVTQR 311

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 529 ISRSSANQRSGRAGRDAPGTAYRLYTESDFYRLPQDTEPEILRCDLSQLVLTLKAHGIDDLLGFPFLTSPPRRALERAMI 608
Cdd:PRK11664  312 ISQASMTQRAGRAGRLEPGICLHLYSKEQAERAAAQSEPEILHSDLSGLLLELLQWGCHDPAQLSWLDQPPAAALAAAKR 391

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|
gi 2431900630 609 HLVQLTALDtTTGKITPLGRDMSGLPLPASLARVLLASAE 648
Cdd:PRK11664  392 LLQQLGALD-GQGRLTARGRKMAALGNDPRLAAMLVAAKE 430
DEXHc_DHX33 cd17978
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ...
 134-323 1.57e-73

DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438710 [Multi-domain]  Cd Length: 178  Bit Score: 239.18  E-value: 1.57e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 134 LPIYSHADHIRQNLREHDVLLLVGETGSGKSTQIPQFLVNEAWCRrqktkgkgsvGGCIAITQPRRVAAISLARRVAEEM 213
Cdd:cd17978     1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFAR----------GGMIGITQPRRVAAVSVAKRVAEEM 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 214 GTPLGNsspasQVGYSVRFENSTSPSTRIKFLTEGMLLQEMLRDPWLKEYSAVVVDEVHERGVNVDLVLGFLRRMHDLRS 293
Cdd:cd17978    71 GVELGQ-----LVGYSVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRK 145

                         170       180       190
                  ....*....|....*....|....*....|
gi 2431900630 294 KddgRGGVPMKVVVMSATADMEKISGFFNG 323
Cdd:cd17978   146 E---QKLSPLKVIIMSATLDADLFSEYFNG 172
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
 385-553 2.58e-71

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 232.81  E-value: 2.58e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 385 HPVTINYTPSPV-----------PDILDAAYERIMHIHSHSPlPGDILVFLTGQETVESLMSLVtnwatsiqKDPKLSRQ 453
Cdd:cd18791     1 FPVEVYYLEDILellgissekedPDYVDAAVRLILQIHRTEE-PGDILVFLPGQEEIERLCELL--------REELLSPD 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 454 LPKLLVLPLYAALPSHMQQRVFQPTPKFTRKIILATNIAETSITVPGVRYVIDTGKAKQRLFRPSLNLDTLLTVPISRSS 533
Cdd:cd18791    72 LGKLLVLPLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKAS 151

                         170       180
                  ....*....|....*....|
gi 2431900630 534 ANQRSGRAGRDAPGTAYRLY 553
Cdd:cd18791   152 AEQRAGRAGRTRPGKCYRLY 171
DEXHc_DHX37 cd17982
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ...
 134-311 2.83e-59

DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350740 [Multi-domain]  Cd Length: 191  Bit Score: 200.66  E-value: 2.83e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 134 LPIYSHADHIRQNLREHDVLLLVGETGSGKSTQIPQFLVNEAWcrrqkTKGKGSVGGCIAITQPRRVAAISLARRVAEEM 213
Cdd:cd17982     1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGF-----GSPESDNPGMIGITQPRRVAAVSMAKRVAEEL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 214 GTPlgnsspASQVGYSVRFENSTSPSTRIKFLTEGMLLQEMLRDPWLKEYSAVVVDEVHERGVNVDLVLGFLRRMHDLRS 293
Cdd:cd17982    76 NVF------GKEVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRA 149

                         170       180
                  ....*....|....*....|
gi 2431900630 294 KDDGRG--GVPMKVVVMSAT 311
Cdd:cd17982   150 KLYLQDqtVKPLKLVIMSAT 169
DEXHc_DHX15 cd17973
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ...
 122-323 1.10e-55

DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438709 [Multi-domain]  Cd Length: 187  Bit Score: 190.32  E-value: 1.10e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 122 ERARQLLSTRQQLPIYSHADHIRQNLREHDVLLLVGETGSGKSTQIPQFLVNEAWCRRQKTKgkgsvggcIAITQPRRVA 201
Cdd:cd17973     1 QRYFEILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELPHQPKKL--------VACTQPRRVA 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 202 AISLARRVAEEMGTPLGnsspaSQVGYSVRFENSTSPSTRIKFLTEGMLLQEMLRDPWLKEYSAVVVDEVHERGVNVDLV 281
Cdd:cd17973    73 AMSVAQRVAEEMDVKLG-----EEVGYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDIL 147

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 2431900630 282 LGFLRRMhdLRSKDDgrggvpMKVVVMSATADMEKISGFFNG 323
Cdd:cd17973   148 MGLLKEV--VRRRPD------LKLIVMSATLDAGKFQKYFDN 181
DEXHc_DHX16 cd17974
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ...
 134-323 2.33e-55

DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350732 [Multi-domain]  Cd Length: 174  Bit Score: 188.87  E-value: 2.33e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 134 LPIYSHADHIRQNLREHDVLLLVGETGSGKSTQIPQFLVNEAWcrrqkTKGKGSVGgCiaiTQPRRVAAISLARRVAEEM 213
Cdd:cd17974     1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGY-----TKGGGKIG-C---TQPRRVAAMSVAARVAEEM 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 214 GTPLGNsspasQVGYSVRFENSTSPSTRIKFLTEGMLLQEMLRDPWLKEYSAVVVDEVHERGVNVDLVLGFLrrmhdlrs 293
Cdd:cd17974    72 GVKLGN-----EVGYSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLV-------- 138

                         170       180       190
                  ....*....|....*....|....*....|
gi 2431900630 294 KDDGRGGVPMKVVVMSATADMEKISGFFNG 323
Cdd:cd17974   139 KDIARFRPDLKLLISSATMDAEKFSAFFDD 168
DEXHc_DHX35 cd17980
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ...
 134-322 1.45e-54

DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350738 [Multi-domain]  Cd Length: 185  Bit Score: 187.29  E-value: 1.45e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 134 LPIYSHADHIRQNLREHDVLLLVGETGSGKSTQIPQFLVNEAWcrrqkTKGkgsvGGCIAITQPRRVAAISLARRVAEEM 213
Cdd:cd17980     1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEAGW-----TAG----GRVVGCTQPRRVAAVTVAGRVAEEM 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 214 GTPLGNsspasQVGYSVRFENSTSP-STRIKFLTEGMLLQEMLRDPWLKEYSAVVVDEVHERGVNVDLVLGFLRRMHDLR 292
Cdd:cd17980    72 GAVLGH-----EVGYCIRFDDCTDPqATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKR 146

                         170       180       190
                  ....*....|....*....|....*....|
gi 2431900630 293 SKddgrggvpMKVVVMSATADMEKISGFFN 322
Cdd:cd17980   147 GD--------LRLIVASATLDAEKFRDFFN 168
DEXHc_DHX38 cd17983
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ...
 134-323 2.38e-53

DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350741 [Multi-domain]  Cd Length: 173  Bit Score: 183.43  E-value: 2.38e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 134 LPIYSHADHIRQNLREHDVLLLVGETGSGKSTQIPQFLVNEAWCRRqktkgkgsvgGCIAITQPRRVAAISLARRVAEEM 213
Cdd:cd17983     1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHEDGYTDY----------GMIGCTQPRRVAAMSVAKRVSEEM 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 214 GTPLGnsspaSQVGYSVRFENSTSPSTRIKFLTEGMLLQEMLRDPWLKEYSAVVVDEVHERGVNVDLVLGFLRRMHDLRS 293
Cdd:cd17983    71 GVELG-----EEVGYAIRFEDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRR 145

                         170       180       190
                  ....*....|....*....|....*....|
gi 2431900630 294 KddgrggvpMKVVVMSATADMEKISGFFNG 323
Cdd:cd17983   146 D--------LKLIVTSATMDADKFADFFGN 167
DEXHc_DHX8 cd17971
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ...
 131-321 3.24e-53

DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350729 [Multi-domain]  Cd Length: 179  Bit Score: 183.07  E-value: 3.24e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 131 RQQLPIYSHADHIRQNLREHDVLLLVGETGSGKSTQIPQFLVNEAWCRRQKTkgkgsvgGCiaiTQPRRVAAISLARRVA 210
Cdd:cd17971     3 RESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAEAGYTSRGKI-------GC---TQPRRVAAMSVAKRVA 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 211 EEMGTPLGNsspasQVGYSVRFENSTSPSTRIKFLTEGMLLQEMLRDPWLKEYSAVVVDEVHERGVNVDLVLGFLRRMHD 290
Cdd:cd17971    73 EEFGCCLGQ-----EVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQ 147

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2431900630 291 LRSKddgrggvpMKVVVMSATADMEKISGFF 321
Cdd:cd17971   148 KRPD--------LKLIVTSATLDAVKFSQYF 170
DEXHc_DHX40 cd17984
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ...
 134-321 8.00e-51

DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350742 [Multi-domain]  Cd Length: 178  Bit Score: 176.58  E-value: 8.00e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 134 LPIYSHADHIRQNLREHDVLLLVGETGSGKSTQIPQFLVNEAWCRRqktkgkgsvgGCIAITQPRRVAAISLARRVAEEM 213
Cdd:cd17984     1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQH----------GMIGVTQPRRVAAISVAQRVAEEM 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 214 GTPLGnsspaSQVGYSVRFENSTSPSTRIKFLTEGMLLQEMLRDPWLKEYSAVVVDEVHERGVNVDLVLGFLRRMHDLRS 293
Cdd:cd17984    71 KCTLG-----SKVGYQVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFQEKS 145

                         170       180
                  ....*....|....*....|....*...
gi 2431900630 294 KddgRGGVPMKVVVMSATADMEKISGFF 321
Cdd:cd17984   146 P---NRKEHLKVVVMSATLELAKLSAFF 170
DEXHc_DHX34 cd17979
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ...
 134-323 2.09e-49

DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350737 [Multi-domain]  Cd Length: 170  Bit Score: 172.24  E-value: 2.09e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 134 LPIYSHADHIRQNLREHDVLLLVGETGSGKSTQIPQFLVNEAWCRrqktkgkgsvggcIAITQPRRVAAISLARRVAEEM 213
Cdd:cd17979     1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFRH-------------IACTQPRRIACISLAKRVAFES 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 214 GTPLGnsspaSQVGYSVRFENSTSPSTRIKFLTEGMLLQEMLRDPWLKEYSAVVVDEVHERGVNVDLVLGFLRRMhdLRS 293
Cdd:cd17979    68 LNQYG-----SKVAYQIRFERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCL--LRL 140

                         170       180       190
                  ....*....|....*....|....*....|
gi 2431900630 294 KDDgrggvpMKVVVMSATADMEKISGFFNG 323
Cdd:cd17979   141 RPD------LKLILMSATINIELFSGYFEG 164
DEXHc_HrpA cd17989
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ...
 134-323 7.11e-48

DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350747 [Multi-domain]  Cd Length: 173  Bit Score: 168.02  E-value: 7.11e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 134 LPIYSHADHIRQNLREHDVLLLVGETGSGKSTQIPQFLVNeawcrrqktKGKGsVGGCIAITQPRRVAAISLARRVAEEM 213
Cdd:cd17989     1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLE---------LGRG-IRGLIGHTQPRRLAARSVAERIAEEL 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 214 GTPLGNSspasqVGYSVRFENSTSPSTRIKFLTEGMLLQEMLRDPWLKEYSAVVVDEVHERGVNVDLVLGFLRRMHDLRS 293
Cdd:cd17989    71 KTELGGA-----VGYKVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRP 145

                         170       180       190
                  ....*....|....*....|....*....|
gi 2431900630 294 KddgrggvpMKVVVMSATADMEKISGFFNG 323
Cdd:cd17989   146 D--------LKVIITSATIDAERFSRHFNN 167
DEXHc_DHX29 cd17975
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ...
 134-322 3.88e-45

DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350733 [Multi-domain]  Cd Length: 183  Bit Score: 160.47  E-value: 3.88e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 134 LPIYSHADHIRQNLREHDVLLLVGETGSGKSTQIPQFLVNEAWCrrqktkGKGSVGGC-IAITQPRRVAAISLARRVAEE 212
Cdd:cd17975     1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEDLLL------NGGTAQKCnIVCTQPRRISAMSLATRVCEE 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 213 MGTPLGNSSPASQVGYSVRFENSTSPSTRIKFLTEGMLLQEMLRDPWLKEYSAVVVDEVHERGVNVDLVLGFLRRMHDLR 292
Cdd:cd17975    75 LGCESGPGGKNSLCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKR 154

                         170       180       190
                  ....*....|....*....|....*....|
gi 2431900630 293 SKddgrggvpMKVVVMSATADMEKISGFFN 322
Cdd:cd17975   155 SD--------LHLILMSATVDCEKFSSYFT 176
DEXHc_HrpB cd17990
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ...
 134-323 3.36e-43

DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438711 [Multi-domain]  Cd Length: 174  Bit Score: 154.80  E-value: 3.36e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 134 LPIYSHADHIRQNLREHDVLLLVGETGSGKSTQIPQFLVNEAWCRRQKtkgkgsvggcIAITQPRRVAAISLARRVAEEM 213
Cdd:cd17990     1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELWIAGGK----------IIVLEPRRVAARAAARRLATLL 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 214 GTPLGNSspasqVGYSVRFENSTSPSTRIKFLTEGMLLQEMLRDPWLKEYSAVVVDEVHERGVNVDLVLGFLRRMHDLRS 293
Cdd:cd17990    71 GEAPGET-----VGYRVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQLLR 145

                         170       180       190
                  ....*....|....*....|....*....|
gi 2431900630 294 KDdgrggvpMKVVVMSATADMEKISGFFNG 323
Cdd:cd17990   146 DD-------LRLLAMSATLDGDGLAALLPE 168
DEXHc_DHX36 cd17981
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ...
 134-322 1.05e-40

DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350739 [Multi-domain]  Cd Length: 180  Bit Score: 147.68  E-value: 1.05e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 134 LPIYSHADHIRQNLREHDVLLLVGETGSGKSTQIPQFLVNEAWCRrqktkGKGSvgGC-IAITQPRRVAAISLARRVAEE 212
Cdd:cd17981     1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILDDAIER-----GKGS--SCrIVCTQPRRISAISVAERVAAE 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 213 MG--TPLGNSspasqVGYSVRFEnSTSPSTR--IKFLTEGMLLQEMLRDPWLKEYSAVVVDEVHERGVNVDLVLGFLRRM 288
Cdd:cd17981    74 RAesCGLGNS-----TGYQIRLE-SRKPRKQgsILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDL 147

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2431900630 289 HDLRSKddgrggvpMKVVVMSATADMEKISGFFN 322
Cdd:cd17981   148 LPFRSD--------LKVILMSATLNAEKFSDYFN 173
DEXHc_DHX30 cd17976
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ...
 134-323 2.15e-39

DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350734 [Multi-domain]  Cd Length: 178  Bit Score: 144.16  E-value: 2.15e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 134 LPIYSHADHIRQNLREHDVLLLVGETGSGKSTQIPQFLVNEAwcrrqKTKGKGSVggC-IAITQPRRVAAISLARRVAEE 212
Cdd:cd17976     1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDY-----VLRGRGAR--CnVVITQPRRISAVSVAQRVAHE 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 213 MGTPLGNSspasqVGYSVRFENSTSPST-RIKFLTEGMLLQEMLRDPWLKEYSAVVVDEVHERGVNVDLVLGFLRRMHDL 291
Cdd:cd17976    74 LGPNLRRN-----VGYQVRLESRPPPRGgALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQL 148

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2431900630 292 RSKddgrggvpMKVVVMSATADMEKISGFFNG 323
Cdd:cd17976   149 NPE--------LRVVLMSATGDNQRLSRYFGG 172
DEXHc_DHX9 cd17972
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ...
 108-321 1.35e-37

DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350730 [Multi-domain]  Cd Length: 234  Bit Score: 140.74  E-value: 1.35e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 108 QTTQQLNNRHSNLKERA---RQLLSTRQQLPIYSHADHIRQNLREHDVLLLVGETGSGKSTQIPQFLVNEAWCrrqktkg 184
Cdd:cd17972    30 QISMDLKNELMYQREQDhnlQQILQERELLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYILDDFIQ------- 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 185 KGSVGGC-IAITQPRRVAAISLARRVAEEMGTPLGNSspasqVGYSVRFENST-SPSTRIKFLTEGMLLQEMlrDPWLKE 262
Cdd:cd17972   103 NDRAAECnIVVTQPRRISAVSVAERVAFERGEEVGKS-----CGYSVRFESVLpRPHASILFCTVGVLLRKL--EAGIRG 175

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2431900630 263 YSAVVVDEVHERGVNVDLVLGFLRRMHDLRSKddgrggvpMKVVVMSATADMEKISGFF 321
Cdd:cd17972   176 ISHVIVDEIHERDINTDFLLVVLRDVVQAYPD--------LRVILMSATIDTSMFCEYF 226
DEXHc_YTHDC2 cd17987
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ...
 134-323 4.60e-35

DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350745 [Multi-domain]  Cd Length: 176  Bit Score: 131.49  E-value: 4.60e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 134 LPIYSHADHIRQNLREHDVLLLVGETGSGKSTQIPQFLVNEAW-----CRrqktkgkgsvggcIAITQPRRVAAISLARR 208
Cdd:cd17987     1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDCYangipCR-------------IFCTQPRRLAAIAVAER 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 209 VAEEMGTPLGNSspasqVGYSVRFENSTSPSTRIKFLTEGMLLQE-MLRDPWLKEYSAVVVDEVHERGVNVDLVLGFLRr 287
Cdd:cd17987    68 VAAERGEKIGQT-----VGYQIRLESRVSPKTLLTFCTNGVLLRTlMAGDSALSTVTHVIVDEVHERDRFSDFLLTKLR- 141

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2431900630 288 mhDLRSKDDGrggvpMKVVVMSATADMEKISGFFNG 323
Cdd:cd17987   142 --DILQKHPN-----LKLILSSAALDVNLFIRYFGS 170
DEXHc_TDRD9 cd17988
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ...
 134-321 9.64e-35

DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350746 [Multi-domain]  Cd Length: 180  Bit Score: 130.70  E-value: 9.64e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 134 LPIYSHADHIRQNLREHDVLLLVGETGSGKSTQIPQFLVNEAWcrrqktkgKGSVGGCIAITQPRRVAAISLARRVAEEM 213
Cdd:cd17988     1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDHYY--------KRGKYCNIVVTQPRRIAAISIARRVSQER 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 214 GTPLGnsspaSQVGYSVRFENSTSPSTRIKFLTEGMLLQEMLRDPWLKEYSAVVVDEVHERGVNVDLVLGFLRRMHDLRS 293
Cdd:cd17988    73 EWTLG-----SLVGYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRTNS 147

                         170       180
                  ....*....|....*....|....*...
gi 2431900630 294 KDdgrggvpMKVVVMSATADMEKISGFF 321
Cdd:cd17988   148 RH-------VKIILMSATISCKEFADYF 168
DEXHc_DHX57 cd17985
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ...
 134-323 1.62e-33

DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350743 [Multi-domain]  Cd Length: 177  Bit Score: 127.26  E-value: 1.62e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 134 LPIYSHADHIRQNLREHDVLLLVGETGSGKSTQIPQFLVnEAWCRRQKTKGKGsvggcIAITQPRRVAAISLARRVAEEM 213
Cdd:cd17985     1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFIL-DNSLQGPPLPVAN-----IICTQPRRISAISVAERVAQER 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 214 GTPLGNSspasqVGYSVRFENSTSPSTRIKFLTEGMLLQEMLRDPWLKEYSAVVVDEVHERGVNVDLVLGFLRRMHDLRS 293
Cdd:cd17985    75 AERVGQS-----VGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRP 149

                         170       180       190
                  ....*....|....*....|....*....|
gi 2431900630 294 KddgrggvpMKVVVMSATADMEKISGFFNG 323
Cdd:cd17985   150 D--------LKVILMSATLNAELFSDYFNS 171
DEXQc_DQX1 cd17986
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ...
 134-320 8.28e-30

DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350744 [Multi-domain]  Cd Length: 177  Bit Score: 116.54  E-value: 8.28e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 134 LPIYSHADHIRQNLREH-DVLLLVGETGSGKSTQIPQflvneaWCRrQKTKGKGSVGGCIAITQPRRVAAISLARRVAEE 212
Cdd:cd17986     1 LPIWAAKFTFLEQLESPsGIVLVSGEPGSGKSTQVPQ------WCA-EFALSRGFQKGQVTVTQPHPLAARSLALRVADE 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 213 MGTPLGNsspasQVGYSVRFENSTSPSTRIKFLTEGMLLQEMLRDPWLKEYSAVVVDEVHERGVNVDLVLGFLRRMHDLR 292
Cdd:cd17986    74 MDLNLGH-----EVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQR 148

                         170       180
                  ....*....|....*....|....*...
gi 2431900630 293 SKddgrggvpMKVVVMSATADMEKISGF 320
Cdd:cd17986   149 PE--------LRVVVVTSPALEPKLRAF 168
DEXHc_DHX32 cd17977
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ...
 134-321 8.00e-28

DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350735 [Multi-domain]  Cd Length: 176  Bit Score: 110.69  E-value: 8.00e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 134 LPIYSHADHIRQNLREHDVLLLVGETGSGKSTQIPQflvneaWCRRQKTKGKGSVGGCIAiTQPRRVAAISLARRVAEEM 213
Cdd:cd17977     1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQ------WCAEYCLSAHYQHGVVVC-TQVHKQTAVWLALRVADEM 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 214 GTPLGNsspasQVGYSVRFENSTSPSTRIKFLTEGMLLQEMLRDPWLKEYSAVVVDEVHERGVNVDLVLGFLRRMHDLRS 293
Cdd:cd17977    74 DVNIGH-----EVGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRP 148

                         170       180
                  ....*....|....*....|....*...
gi 2431900630 294 KddgrggvpMKVVVMSATADMEKISGFF 321
Cdd:cd17977   149 E--------LKLVIITCPHLSSKLLSYY 168
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 606-727 2.78e-22

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 92.30  E-value: 2.78e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 606 AMIHLVQLTALDTTtGKITPLGRDMSGLPLPASLARVLLASAepEFDCVDEIVDIVSALSVENVFLNIHRNQSDGLQNDN 685
Cdd:pfam04408   1 ALELLYYLGALDED-GELTPLGRKMAELPLDPRLAKMLLAAA--ELGCLDEVLTIVAALSVRDPFVQPNFLDPRSAAKAA 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2431900630 686 NRRGEGDGDGDVDADAENEtrearaeryrrvlfrREGDHLTL 727
Cdd:pfam04408  78 RRRRRAADEKARAKFARLD---------------LEGDHLTL 104
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 818-898 5.29e-18

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 79.22  E-value: 5.29e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 818 ILKCILTGFHANVARLSPDG-SYRTVLTNQPVAIHPSSVLFSAGGgggggpKKFEGIVYNEFVYTgTKAYARGVSAVEMR 896
Cdd:pfam07717   1 LRAALAAGLYPNVARRDPKGkGYTTLSDNQRVFIHPSSVLFNEKT------FPPEWVVYQELVET-TKVYIRTVTAISPE 73


                  ..
gi 2431900630 897 WL 898
Cdd:pfam07717  74 WL 75
DEXDc smart00487
DEAD-like helicases superfamily;
147-312 1.14e-16

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 79.46  E-value: 1.14e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630  147 LREHDVLLLVGETGSGKSTQIPQFLVNeawcrrqktKGKGSVGGCIAITQPRRVAAISLARRVAEEMGtPLGNSSPASQV 226
Cdd:smart00487  21 LSGLRDVILAAPTGSGKTLAALLPALE---------ALKRGKGGRVLVLVPTRELAEQWAEELKKLGP-SLGLKVVGLYG 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630  227 GYSVR--FENSTSPSTRIKFLTEGMLLQEMLRDP-WLKEYSAVVVDEVHERGVNV--DLVLGFLRRMHDLRskddgrggv 301
Cdd:smart00487  91 GDSKReqLRKLESGKTDILVTTPGRLLDLLENDKlSLSNVDLVILDEAHRLLDGGfgDQLEKLLKLLPKNV--------- 161

                          170
                   ....*....|.
gi 2431900630  302 pmKVVVMSATA 312
Cdd:smart00487 162 --QLLLLSATP 170
HA2 smart00847
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ...
 612-679 1.41e-13

Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 214852 [Multi-domain]  Cd Length: 82  Bit Score: 66.91  E-value: 1.41e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2431900630  612 QLTALDTTtGKITPLGRDMSGLPLPASLARVLLASAepEFDCVDEIVDIVSALSVENVFLNIHRNQSD 679
Cdd:smart00847   1 ELGALDDD-GRLTPLGRKMAELPLDPRLAKMLLAAA--EFGCLDEILTIVAMLSVGDPRPKEKREDAD 65
HELICc smart00490
helicase superfamily c-terminal domain;
459-544 3.97e-13

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 65.31  E-value: 3.97e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630  459 VLPLYAALPSHMQQRVFQPTPKFTRKIILATNIAETSITVPGVRYVIDTGkakqrlfrpslnldtlltVPISRSSANQRS 538
Cdd:smart00490  14 VARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYD------------------LPWSPASYIQRI 75


                   ....*.
gi 2431900630  539 GRAGRD 544
Cdd:smart00490  76 GRAGRA 81
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 404-543 2.54e-11

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 61.07  E-value: 2.54e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 404 YERIMHIHSHSPlPGDILVFLTGQETVESlmslvtnwatsiqkdpKLSRQLPKLLVLPLYAALPSHMQQRVFQPTPKFTR 483
Cdd:pfam00271   3 LEALLELLKKER-GGKVLIFSQTKKTLEA----------------ELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKI 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 484 KIILATNIAETSITVPGVRYVIDtgkakqrlFRPSLNLDTLLtvpisrssanQRSGRAGR 543
Cdd:pfam00271  66 DVLVATDVAERGLDLPDVDLVIN--------YDLPWNPASYI----------QRIGRAGR 107
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
 153-311 3.70e-09

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 56.26  E-value: 3.70e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 153 LLLVGETGSGKSTQIPQFLVNEAwcrrqKTKGKGSVggciaITQPRRvaaiSLARRVAEEMGTPLGNSSPasqVGYSVRF 232
Cdd:cd00046     4 VLITAPTGSGKTLAALLAALLLL-----LKKGKKVL-----VLVPTK----ALALQTAERLRELFGPGIR---VAVLVGG 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 233 ENS------TSPSTRIKFLTEGMLLQEMLRD--PWLKEYSAVVVDEVHERGVNVDLVLGFLRRMHDLRSKDdgrggvpMK 304
Cdd:cd00046    67 SSAeereknKLGDADIIIATPDMLLNLLLREdrLFLKDLKLIIVDEAHALLIDSRGALILDLAVRKAGLKN-------AQ 139


                  ....*..
gi 2431900630 305 VVVMSAT 311
Cdd:cd00046   140 VILLSAT 146
PHA02653 PHA02653
RNA helicase NPH-II; Provisional
 485-554 2.59e-07

RNA helicase NPH-II; Provisional


Pssm-ID: 177443 [Multi-domain]  Cd Length: 675  Bit Score: 54.60  E-value: 2.59e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2431900630 485 IILATNIAETSITVPGVRYVIDTGkakqRLFRPSlnldtlltvP-------ISRSSANQRSGRAGRDAPGTAYRLYT 554
Cdd:PHA02653  449 IIISTPYLESSVTIRNATHVYDTG----RVYVPE---------PfggkemfISKSMRTQRKGRVGRVSPGTYVYFYD 512
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
 484-550 4.34e-06

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 45.39  E-value: 4.34e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2431900630 484 KIILATNIAETSITVPGVRYVIDTGkakqrlfrpslnldtlltVPISRSSANQRSGRAGRDAPGTAY 550
Cdd:cd18785    24 EILVATNVLGEGIDVPSLDTVIFFD------------------PPSSAASYIQRVGRAGRGGKDEGE 72
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 147-315 9.97e-06

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 46.85  E-value: 9.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 147 LREHDVLLlVGETGSGKST--QIPqflvneAWCRRQKTKGKGSVggciAITQPRRvaaiSLAR---RVAEEMGTPLGNSS 221
Cdd:pfam00270  12 LEGRDVLV-QAPTGSGKTLafLLP------ALEALDKLDNGPQA----LVLAPTR----ELAEqiyEELKKLGKGLGLKV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 222 PASQVGYSVRFENSTSPSTRIKFLTEGMLLQEMLRDPWLKEYSAVVVDEVHE-----RGVNVDLVLGFLRRMHdlrskdd 296
Cdd:pfam00270  77 ASLLGGDSRKEQLEKLKGPDILVGTPGRLLDLLQERKLLKNLKLLVLDEAHRlldmgFGPDLEEILRRLPKKR------- 149

                         170
                  ....*....|....*....
gi 2431900630 297 grggvpmKVVVMSATADME 315
Cdd:pfam00270 150 -------QILLLSATLPRN 161
DEXHc_viral_Ns3 cd17931
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional ...
 159-272 3.20e-04

DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional protein found in pestiviruses that contains an N-terminal protease and a C-terminal helicase. The N-terminal domain is a chymotrypsin-like serine protease, which is responsible for most of the maturation cleavages of the polyprotein precursor in the cytosolic side of the endoplasmic reticulum membrane. The C-terminal domain, about two-thirds of NS3, is a helicase belonging to superfamily 2 (SF2) thought to be important for unwinding highly structured regions of the RNA genome during replication. NS3 plays an essential role in viral polyprotein processing and genome replication. NS3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350689 [Multi-domain]  Cd Length: 151  Bit Score: 42.15  E-value: 3.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 159 TGSGKSTQIPQFLVNEAWCRRQKTkgkgsvggciAITQPRRVAAISlarrVAEEM-GTPLGNSSPASQVGysvrfensTS 237
Cdd:cd17931    10 PGAGKTTRVLPQIIREAIKKRLRT----------LVLAPTRVVAAE----MYEALrGLPIRYRTGAVKEE--------HG 67

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2431900630 238 PSTRIKFLTEGMLLQEMLRDPWLKEYSAVVVDEVH 272
Cdd:cd17931    68 GNEIVDYMCHGTFTCRLLSPKRVPNYNLIIMDEAH 102
PRK02362 PRK02362
ATP-dependent DNA helicase;
258-311 1.98e-03

ATP-dependent DNA helicase;


Pssm-ID: 235032 [Multi-domain]  Cd Length: 737  Bit Score: 41.87  E-value: 1.98e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2431900630 258 PWLKEYSAVVVDEVH-----ERGVNVDLVLGFLRRMHdlrskddgrggVPMKVVVMSAT 311
Cdd:PRK02362  133 PWLDDITCVVVDEVHlidsaNRGPTLEVTLAKLRRLN-----------PDLQVVALSAT 180
DEXHc_Ski2 cd17921
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ...
 133-322 4.52e-03

DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350679 [Multi-domain]  Cd Length: 181  Bit Score: 39.17  E-value: 4.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 133 QLPIYSHADHirqnlrEHDVLLLVGETGSGKSTqIPQFLVNEAWCRrqktkgkgsVGGCIAITQPRRvaaiSLARRVAE- 211
Cdd:cd17921     6 QREALRALYL------SGDSVLVSAPTSSGKTL-IAELAILRALAT---------SGGKAVYIAPTR----ALVNQKEAd 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 212 --EMGTPLGnsspaSQVG--YSVRFENSTSPS-TRIKFLT----EGMLLQemLRDPWLKEYSAVVVDEVH-----ERGVN 277
Cdd:cd17921    66 lrERFGPLG-----KNVGllTGDPSVNKLLLAeADILVATpeklDLLLRN--GGERLIQDVRLVVVDEAHligdgERGVV 138

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 2431900630 278 VDLVLGFLRRMHDlrskddgrggvPMKVVVMSAT-ADMEKISGFFN 322
Cdd:cd17921   139 LELLLSRLLRINK-----------NARFVGLSATlPNAEDLAEWLG 173
AAA_22 pfam13401
AAA domain;
152-295 6.25e-03

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 37.71  E-value: 6.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900630 152 VLLLVGETGSGKSTQIpQFLVNEAWCRRQktkgkgsvgGCIAITQPRRVAAISLARRVAEEMGTPLGNSspasqvgysvr 231
Cdd:pfam13401   7 ILVLTGESGTGKTTLL-RRLLEQLPEVRD---------SVVFVDLPSGTSPKDLLRALLRALGLPLSGR----------- 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2431900630 232 fenstspstrikfLTEGMLLQEMLRdpWLKEYSA---VVVDEVHergvNVDL-VLGFLRRMHDLRSKD 295
Cdd:pfam13401  66 -------------LSKEELLAALQQ--LLLALAVavvLIIDEAQ----HLSLeALEELRDLLNLSSKL 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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