NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2431900642|gb|KAJ4622514|]
View 

hypothetical protein HRR88_005526 [Exophiala dermatitidis]

Protein Classification

calcium/proton exchanger( domain architecture ID 1903228)

calcium/proton exchanger translocates Ca(2+) and other metal ions into vacuoles using the proton gradient formed by H(+)-ATPase and H(+)-pyrophosphatase

Gene Ontology:  GO:0015369|GO:0006816|GO:0008324
TCDB:  2.A.19

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Na_Ca_ex super family cl46895
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 74-607 6.15e-70

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


The actual alignment was detected with superfamily member TIGR00378:

Pssm-ID: 481235 [Multi-domain]  Cd Length: 349  Bit Score: 230.13  E-value: 6.15e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642  74 LLVFVPVGIAVHFAGVDPNVVFALNAVAIIPLAGLLTFATESVAHRLGPTLGALLNVSFGNAVELIIFIIALVKNEIRIV 153
Cdd:TIGR00378   1 LLVFVPLSVIGSLMHWPSTVLFAVYCLAIIPLAAYMGRATEELAIIAGPRIGGLLNATFGNAVELIISIIALKEGLTGIV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642 154 QASLIGSLLANLLLILGMAFLIGGLEFQEQIYDSTVTQMSACLLALAVLSLLIPTAFhaSFNDLDVADKAVIKLSRGTSV 233
Cdd:TIGR00378  81 LASLTGSVLGNLLLVAGLSFFVGGLKYKRQEFNIHAARHNSSLLIFAIVAFLIPAAF--EVFSVGMENASKLNLSIGISI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642 234 ILLIIYFLYLLFQLKSHAYLYQgtpqhvideeavpgflsrfdstssssasssrvstassgsqrrvrkrlkmqlgrkrhek 313
Cdd:TIGR00378 159 VMILVYVLALYFKLGTHRGLYQ---------------------------------------------------------- 180

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642 314 ieiedeadiggteqsnaitPGDilAEKTEEPAEmetgsdptislpptntstpaaptgttanpatkgkkpvlgprgisirt 393
Cdd:TIGR00378 181 -------------------PNN--AEQTEEMEE----------------------------------------------- 192

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642 394 ppvfrsstlppgGNKPPEHQYNGNLrryrsdpdhgadsrrgsgplarramapsipaededappmgqtaSIILLLISTGLV 473
Cdd:TIGR00378 193 ------------IEREPEHSWSGKV-------------------------------------------ATIVLLAATIVV 217

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642 474 ALCAEFLVGSIEHLVENSPLSEAFVGLIILPIVGNAAEHVTAVTVAAKNKLDLALGVSLGSSIQIALFVTPVVVILGWIL 553
Cdd:TIGR00378 218 AYISENLVGTFHSVAESFGLSELFIGVIVVPIVGNAAEHATAVIVAMKDKMDLAVEVAVGSSLQIAMFVAPVLVIVGWFI 297

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2431900642 554 NKDMSLYFSLFETGSLFVSTFIVNFLVLDGRSNYLEGALLCACYVIVAVGayFF 607
Cdd:TIGR00378 298 PTPMPLNFTLFELVAMVSAVLLMNAISNDGDSNWLEGATLLAAYVIMAIA--FF 349
 
Name Accession Description Interval E-value
cax TIGR00378
calcium/proton exchanger (cax); [Transport and binding proteins, Cations and iron carrying ...
 74-607 6.15e-70

calcium/proton exchanger (cax); [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273043 [Multi-domain]  Cd Length: 349  Bit Score: 230.13  E-value: 6.15e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642  74 LLVFVPVGIAVHFAGVDPNVVFALNAVAIIPLAGLLTFATESVAHRLGPTLGALLNVSFGNAVELIIFIIALVKNEIRIV 153
Cdd:TIGR00378   1 LLVFVPLSVIGSLMHWPSTVLFAVYCLAIIPLAAYMGRATEELAIIAGPRIGGLLNATFGNAVELIISIIALKEGLTGIV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642 154 QASLIGSLLANLLLILGMAFLIGGLEFQEQIYDSTVTQMSACLLALAVLSLLIPTAFhaSFNDLDVADKAVIKLSRGTSV 233
Cdd:TIGR00378  81 LASLTGSVLGNLLLVAGLSFFVGGLKYKRQEFNIHAARHNSSLLIFAIVAFLIPAAF--EVFSVGMENASKLNLSIGISI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642 234 ILLIIYFLYLLFQLKSHAYLYQgtpqhvideeavpgflsrfdstssssasssrvstassgsqrrvrkrlkmqlgrkrhek 313
Cdd:TIGR00378 159 VMILVYVLALYFKLGTHRGLYQ---------------------------------------------------------- 180

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642 314 ieiedeadiggteqsnaitPGDilAEKTEEPAEmetgsdptislpptntstpaaptgttanpatkgkkpvlgprgisirt 393
Cdd:TIGR00378 181 -------------------PNN--AEQTEEMEE----------------------------------------------- 192

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642 394 ppvfrsstlppgGNKPPEHQYNGNLrryrsdpdhgadsrrgsgplarramapsipaededappmgqtaSIILLLISTGLV 473
Cdd:TIGR00378 193 ------------IEREPEHSWSGKV-------------------------------------------ATIVLLAATIVV 217

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642 474 ALCAEFLVGSIEHLVENSPLSEAFVGLIILPIVGNAAEHVTAVTVAAKNKLDLALGVSLGSSIQIALFVTPVVVILGWIL 553
Cdd:TIGR00378 218 AYISENLVGTFHSVAESFGLSELFIGVIVVPIVGNAAEHATAVIVAMKDKMDLAVEVAVGSSLQIAMFVAPVLVIVGWFI 297

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2431900642 554 NKDMSLYFSLFETGSLFVSTFIVNFLVLDGRSNYLEGALLCACYVIVAVGayFF 607
Cdd:TIGR00378 298 PTPMPLNFTLFELVAMVSAVLLMNAISNDGDSNWLEGATLLAAYVIMAIA--FF 349
ChaA COG0387
Cation (Ca2+/Na+/K+)/H+ antiporter ChaA [Inorganic ion transport and metabolism];
450-606 4.72e-50

Cation (Ca2+/Na+/K+)/H+ antiporter ChaA [Inorganic ion transport and metabolism];


Pssm-ID: 440156 [Multi-domain]  Cd Length: 362  Bit Score: 177.66  E-value: 4.72e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642 450 EDEDAPPMGQT-ASIILLLISTGLVALCAEFLVGSIEHLVENSPLSEAFVGLIIlPIVGNAAEHVTAVTVAAKNKLDLAL 528
Cdd:COG0387   205 EHEEPPSKWSLlLSLGLLLVALVAVVLLSEILVGSIEEAVEALGLPEAFVGVII-AILVLAPEGLTAVRAARKNRLQLSL 283

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2431900642 529 GVSLGSSIQIALFVTPVVVILGWILNKDMSLYFSLFETGSLFVSTFIVNFLVLDGRSNYLEGALLCACYVIVAVGAYF 606
Cdd:COG0387   284 NIALGSALASIGLTIPALVLISLLTGQPLTLGFNPFELVLLALTVLVSNLTFSDGRTNWLEGAVHLALFAIYAFLFFF 361
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 462-606 1.79e-24

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 99.60  E-value: 1.79e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642 462 SIILLLISTGLVALCAEFLVGSIEHLVENSPLSEAFVGLIILPIVGNAAEHVTAVTVAAKNKLDLALGVSLGSSIQIALF 541
Cdd:pfam01699   2 SLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNILL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2431900642 542 VTPVVVILGWILNKDMSLYFS---LFETGSLFVSTFIVNFLVLDGRSNYLEGALLCACYVIVAVGAYF 606
Cdd:pfam01699  82 VLGLSALIGPVKVDSLLLKLDlgvLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
 
Name Accession Description Interval E-value
cax TIGR00378
calcium/proton exchanger (cax); [Transport and binding proteins, Cations and iron carrying ...
 74-607 6.15e-70

calcium/proton exchanger (cax); [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273043 [Multi-domain]  Cd Length: 349  Bit Score: 230.13  E-value: 6.15e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642  74 LLVFVPVGIAVHFAGVDPNVVFALNAVAIIPLAGLLTFATESVAHRLGPTLGALLNVSFGNAVELIIFIIALVKNEIRIV 153
Cdd:TIGR00378   1 LLVFVPLSVIGSLMHWPSTVLFAVYCLAIIPLAAYMGRATEELAIIAGPRIGGLLNATFGNAVELIISIIALKEGLTGIV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642 154 QASLIGSLLANLLLILGMAFLIGGLEFQEQIYDSTVTQMSACLLALAVLSLLIPTAFhaSFNDLDVADKAVIKLSRGTSV 233
Cdd:TIGR00378  81 LASLTGSVLGNLLLVAGLSFFVGGLKYKRQEFNIHAARHNSSLLIFAIVAFLIPAAF--EVFSVGMENASKLNLSIGISI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642 234 ILLIIYFLYLLFQLKSHAYLYQgtpqhvideeavpgflsrfdstssssasssrvstassgsqrrvrkrlkmqlgrkrhek 313
Cdd:TIGR00378 159 VMILVYVLALYFKLGTHRGLYQ---------------------------------------------------------- 180

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642 314 ieiedeadiggteqsnaitPGDilAEKTEEPAEmetgsdptislpptntstpaaptgttanpatkgkkpvlgprgisirt 393
Cdd:TIGR00378 181 -------------------PNN--AEQTEEMEE----------------------------------------------- 192

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642 394 ppvfrsstlppgGNKPPEHQYNGNLrryrsdpdhgadsrrgsgplarramapsipaededappmgqtaSIILLLISTGLV 473
Cdd:TIGR00378 193 ------------IEREPEHSWSGKV-------------------------------------------ATIVLLAATIVV 217

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642 474 ALCAEFLVGSIEHLVENSPLSEAFVGLIILPIVGNAAEHVTAVTVAAKNKLDLALGVSLGSSIQIALFVTPVVVILGWIL 553
Cdd:TIGR00378 218 AYISENLVGTFHSVAESFGLSELFIGVIVVPIVGNAAEHATAVIVAMKDKMDLAVEVAVGSSLQIAMFVAPVLVIVGWFI 297

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2431900642 554 NKDMSLYFSLFETGSLFVSTFIVNFLVLDGRSNYLEGALLCACYVIVAVGayFF 607
Cdd:TIGR00378 298 PTPMPLNFTLFELVAMVSAVLLMNAISNDGDSNWLEGATLLAAYVIMAIA--FF 349
caca2 TIGR00846
calcium/proton exchanger; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the ...
 65-601 4.69e-66

calcium/proton exchanger; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is generated from the calcium ion/proton exchangers of the CacA family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273297 [Multi-domain]  Cd Length: 363  Bit Score: 220.40  E-value: 4.69e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642  65 ALFHSWVNVLLVFVPVGIAVHFAGVDPNVVFALNAVAIIPLAGLLTFATESVAHRLGPTLGALLNVSFGNAVELIIFIIA 144
Cdd:TIGR00846   1 VLLGSWLNILLIFVPAAIILGHWGSSQTLIFLLNLLGILPLAARVSFHTEELAHRLGETLGGLLNATFGNAVELIVSIMA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642 145 LVKNEIRIVQASLIGSLLANLLLILGMAFLIGGLEF--QEQIYDSTVTQMSACLLALAVLSLLIPTAFHASFNDLDVADK 222
Cdd:TIGR00846  81 LGNGKVEVVRDSLLGSILSNLLLVLGLCLLLGGIANirREQTFDRGAAQTNFALLLLAILSLLLPAALPAAKPHEKSDHF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642 223 --AVIKLSRGTSVILLIIYFLYLLFQLKSHAYLYqgtpqhVIDEEAVpgflsrfdstssssasssrvstassgsqrrvrk 300
Cdd:TIGR00846 161 qdMILGLSRGTAIVSLILYGAFLVFQLWTHRQLF------EAQEEED--------------------------------- 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642 301 rlkmqlgrkrhekieieDEADiggteqsnaitpgdilaekteepaemetgsdptislpptntstpaaptgttanPATKGK 380
Cdd:TIGR00846 202 -----------------SEVD-----------------------------------------------------DEVHEK 211

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642 381 KPVLGPRgisirtppvfrsstlppggnkppehqyngnlrryrsdpdhgadsrrgsgplarramapsipaededappmgqt 460
Cdd:TIGR00846 212 PTVLSPW------------------------------------------------------------------------- 218

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642 461 ASIILLLISTGLVALCAEFLVGSIEHLVENSPLSEAFVGLIILPIVGNAAEHVTAVTVAAKNKLDLALGVSLGSSIQIAL 540
Cdd:TIGR00846 219 SAAAWLVGTTIAIILLADYLVDTIDDAVDSWGLSVAFIGLILAPIVGNAAEHVTAVKAALKNKLDLALGVALGSALQIIL 298

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2431900642 541 FVTPVVVILGWILNKDMSLYFSLFETGSLFVSTFIVNFLVLDGRSNYLEGALLCACYVIVA 601
Cdd:TIGR00846 299 FVVPLVVLVAWMLGIPMDLNFGTFETIVLALSLFLTTITLQDGRSNYLEGAVLLALYIIIA 359
ChaA COG0387
Cation (Ca2+/Na+/K+)/H+ antiporter ChaA [Inorganic ion transport and metabolism];
450-606 4.72e-50

Cation (Ca2+/Na+/K+)/H+ antiporter ChaA [Inorganic ion transport and metabolism];


Pssm-ID: 440156 [Multi-domain]  Cd Length: 362  Bit Score: 177.66  E-value: 4.72e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642 450 EDEDAPPMGQT-ASIILLLISTGLVALCAEFLVGSIEHLVENSPLSEAFVGLIIlPIVGNAAEHVTAVTVAAKNKLDLAL 528
Cdd:COG0387   205 EHEEPPSKWSLlLSLGLLLVALVAVVLLSEILVGSIEEAVEALGLPEAFVGVII-AILVLAPEGLTAVRAARKNRLQLSL 283

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2431900642 529 GVSLGSSIQIALFVTPVVVILGWILNKDMSLYFSLFETGSLFVSTFIVNFLVLDGRSNYLEGALLCACYVIVAVGAYF 606
Cdd:COG0387   284 NIALGSALASIGLTIPALVLISLLTGQPLTLGFNPFELVLLALTVLVSNLTFSDGRTNWLEGAVHLALFAIYAFLFFF 361
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 462-606 1.79e-24

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 99.60  E-value: 1.79e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642 462 SIILLLISTGLVALCAEFLVGSIEHLVENSPLSEAFVGLIILPIVGNAAEHVTAVTVAAKNKLDLALGVSLGSSIQIALF 541
Cdd:pfam01699   2 SLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNILL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2431900642 542 VTPVVVILGWILNKDMSLYFS---LFETGSLFVSTFIVNFLVLDGRSNYLEGALLCACYVIVAVGAYF 606
Cdd:pfam01699  82 VLGLSALIGPVKVDSLLLKLDlgvLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
ChaA COG0387
Cation (Ca2+/Na+/K+)/H+ antiporter ChaA [Inorganic ion transport and metabolism];
65-192 1.12e-23

Cation (Ca2+/Na+/K+)/H+ antiporter ChaA [Inorganic ion transport and metabolism];


Pssm-ID: 440156 [Multi-domain]  Cd Length: 362  Bit Score: 102.93  E-value: 1.12e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642  65 ALFHSWVNVLLVFVPVGIAVHFA----GVDPNVVFALNAVAIIPLAGLLTFATESVAHRLGPTLGALLNVSFGNAVELII 140
Cdd:COG0387     2 SLLRRILPLLLLFVPIAALALFLlhggRWGPVLVFILAALAIIPLAFAAVHHAEVLAHRLGEPFGGLLLATFGNAIEVIL 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2431900642 141 FIIALV--KNEIRIVQASLIGSLLANLLLILGMAFLIGGLEFQEQIYDSTVTQM 192
Cdd:COG0387    82 IISAMLagEELPTLVRDTIFGAIMINLNGVLGLSLLLGGLRHKEQEFNLQGARA 135
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
440-599 9.07e-15

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 75.17  E-value: 9.07e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642 440 RRAMAPSIPAEDEDAPPMGQTASIILLLISTGLVALCAEFLVGSIEHLVENSPLSEAFVGLIILPIVGNAAEHVTAVTVA 519
Cdd:COG0530   131 KEPAWEEVEEELEEKPKMSLWKALLLLVLGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAA 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642 520 AKNKLDLALGVSLGSSIQIALFVTPVVVILGWILNKDMSLYFSLFetGSLFVSTFIVNFLVLDGRSNYLEGALLCACYVI 599
Cdd:COG0530   211 RKGEDDLAVGNIIGSNIFNILLVLGIGALITPIPVDPAVLSFDLP--VMLAATLLLLGLLRTGGRIGRWEGLLLLALYLA 288
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
477-605 6.16e-09

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 57.45  E-value: 6.16e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642 477 AEFLVGSIEHLVENSPLSEAFVGLIILPIVGNAAEHVTAVTVAAKNKLDLALGVSLGSSIQIALFVTPVVVILGwilnkD 556
Cdd:COG0530     1 ADLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIR-----P 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2431900642 557 MSLYFSLF--ETGSLFVSTFIVNFLVLDGRSNYLEGALLCACYVIVAVGAY 605
Cdd:COG0530    76 LAVDRRVLrrDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYLI 126
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 463-599 1.09e-06

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 50.79  E-value: 1.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642 463 IILLLISTGLVALCAEFLVGSIEHLVENSPLSEAFVGLIILPIVGNAAEHVTAVTVAAKNKLDLALGVSLGSSI------ 536
Cdd:TIGR00367   4 IGYLILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIfnilli 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2431900642 537 -QIALFVTPVVViLGWILNKDMSLYfslfetgslFVSTFIVNFLVLDGRSNYLEGALLCACYVI 599
Cdd:TIGR00367  84 lGLSAIFSPIIV-DKDWLRRDILFY---------LLVSILLLFFGLDGQISRIDGVVLLILYIV 137
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 93-178 4.74e-05

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 43.75  E-value: 4.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642  93 VVFALNAVAIIPLAGLLTFATESVAHRLG---PTLGALLNVSFGNAVELIIFIIALVKNEIRIVQASLIGSLLANLLLIL 169
Cdd:pfam01699   4 LLFILGLLLISVAADLLVDSAEVLARVLGisgTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNILLVL 83


                  ....*....
gi 2431900642 170 GMAFLIGGL 178
Cdd:pfam01699  84 GLSALIGPV 92
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 462-599 5.85e-05

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 45.39  E-value: 5.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431900642 462 SIILLLISTGLVALCAEFLVGSIEHLVENSPLSEAFVGLIILPIVGNAAEHVTAVTVAAKNKLDLALGVSLGSSIQIALF 541
Cdd:TIGR00367 171 SLVLLIIGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVGNVIGSNIFNILV 250

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2431900642 542 VTPVVVILGWILNKDMSLYFSLfeTGSLFVSTFIVNFLVLDGRSNYLEGALLCACYVI 599
Cdd:TIGR00367 251 GLGVPSLFMPIPVEPLAYNLDA--PVMVIVTLLLMLFFKTSMKLGRWEGILLLALYIA 306
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH