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Conserved domains on  [gi|2477810793|gb|KAJ8242561|]
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hypothetical protein LV156_000171 [Aspergillus fumigatus]

Protein Classification

bromodomain-containing protein( domain architecture ID 10860798)

bromodomain-containing protein with a BET (bromodomain extra-terminal) domain may act as transcription regulator involved in chromatin-based DNA damage response (DDR) pathways, which maintain genome integrity from cell-intrinsic and extrinsic DNA-damaging sources

CATH:  1.20.920.10
Gene Ontology:  GO:0005515|GO:0006338|GO:0006357|GO:0070577
PubMed:  26472704|1350857|34548613|28847823|31582847
SCOP:  4000871

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 280-382 4.79e-57

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


:

Pssm-ID: 99932  Cd Length: 103  Bit Score: 190.22  E-value: 4.79e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 280 MTKVQHKFVLKGIQSLKRMNDARFYREPVDPIKMNIPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVT 359
Cdd:cd05500     1 MTKHQHKFLLSSIRSLKRLKDARPFLVPVDPVKLNIPHYPTIIKKPMDLGTIERKLKSNVYTSVEEFTADFNLMVDNCLT 80

                          90       100
                  ....*....|....*....|...
gi 2477810793 360 FNGPDHLVSQEGLKLKGTFEKQM 382
Cdd:cd05500    81 FNGPEHPVSQMGKRLQAAFEKHL 103
Bromo_BDF1_2_II cd05499
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast ...
 477-578 5.20e-54

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


:

Pssm-ID: 99931  Cd Length: 102  Bit Score: 181.71  E-value: 5.20e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 477 ELRFCQEVLDELHKPKHYNWAAPFYFPVDPVALNIPTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFKF 556
Cdd:cd05499     1 ELKFCEEVLKELMKPKHSAYNWPFLDPVDPVALNIPNYFSIIKKPMDLGTISKKLQNGQYQSAKEFERDVRLIFKNCYTF 80

                          90       100
                  ....*....|....*....|..
gi 2477810793 557 NIPGDPTYMAGQRFQEIFENKW 578
Cdd:cd05499    81 NPEGTDVYMMGHQLEEVFNDKW 102
BET pfam17035
Bromodomain extra-terminal - transcription regulation; The BET, or bromodomain extra-terminal ...
 686-750 5.62e-19

Bromodomain extra-terminal - transcription regulation; The BET, or bromodomain extra-terminal domain, is found on bromodomain proteins that play key roles in development, cancer progression and virus-host pathogenesis. It interacts with NSD3, JMJD6, CHD4, GLTSCR1, and ATAD5 all of which are shown to impart a pTEFb-independent transcriptional activation function on the bromodomain proteins.


:

Pssm-ID: 435704  Cd Length: 64  Bit Score: 81.39  E-value: 5.62e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2477810793 686 YVTYHEKQIISNGISSLPDKKMQEALKIIQSNVPALKGTQEtEIELDIDELPNEVLLMLLKFVKK 750
Cdd:pfam17035   1 PMTYEEKRELSERINKLPGEKLGRVIEIIKERNPELQSDDD-EIELDIDALDDDTLRKLYNFVKK 64
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 2-270 5.30e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 5.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793    2 ATPPPEAPPvvKEDKPQLPPSPNGASSVdvgltstqNHVTEVSPINGTNKPEENDKTATLNCQGTEQLSLTNGAGSTVSP 81
Cdd:PHA03247  2610 GPAPPSPLP--PDTHAPDPPPPSPSPAA--------NEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSP 2679

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793   82 PKSPTEPAdVPAPSGTTATqkeeekpLTSTPADGSDKEPKLENLIPDAPVTQETGSTVGTDQASPQDTKASQDVSKPPTD 161
Cdd:PHA03247  2680 PQRPRRRA-ARPTVGSLTS-------LADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATP 2751

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793  162 sssdakvennvqdsGVKTELPHHPSTSTKLDTMPGDNPTSNAPtvpslqtsdQDMPDAPDAPMSPTKVSRERDADADDEP 241
Cdd:PHA03247  2752 --------------GGPARPARPPTTAGPPAPAPPAAPAAGPP---------RRLTRPAVASLSESRESLPSPWDPADPP 2808

                          250       260
                   ....*....|....*....|....*....
gi 2477810793  242 APKRTKLEDEGSAEVKLPDLPTPVTETPA 270
Cdd:PHA03247  2809 AAVLAPAAALPPAASPAGPLPPPTSAQPT 2837
 
Name Accession Description Interval E-value
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 280-382 4.79e-57

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 190.22  E-value: 4.79e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 280 MTKVQHKFVLKGIQSLKRMNDARFYREPVDPIKMNIPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVT 359
Cdd:cd05500     1 MTKHQHKFLLSSIRSLKRLKDARPFLVPVDPVKLNIPHYPTIIKKPMDLGTIERKLKSNVYTSVEEFTADFNLMVDNCLT 80

                          90       100
                  ....*....|....*....|...
gi 2477810793 360 FNGPDHLVSQEGLKLKGTFEKQM 382
Cdd:cd05500    81 FNGPEHPVSQMGKRLQAAFEKHL 103
Bromo_BDF1_2_II cd05499
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast ...
 477-578 5.20e-54

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99931  Cd Length: 102  Bit Score: 181.71  E-value: 5.20e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 477 ELRFCQEVLDELHKPKHYNWAAPFYFPVDPVALNIPTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFKF 556
Cdd:cd05499     1 ELKFCEEVLKELMKPKHSAYNWPFLDPVDPVALNIPNYFSIIKKPMDLGTISKKLQNGQYQSAKEFERDVRLIFKNCYTF 80

                          90       100
                  ....*....|....*....|..
gi 2477810793 557 NIPGDPTYMAGQRFQEIFENKW 578
Cdd:cd05499    81 NPEGTDVYMMGHQLEEVFNDKW 102
BROMO smart00297
bromo domain;
477-580 8.42e-29

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 110.83  E-value: 8.42e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793  477 ELRFCQEVLDELHKPKH-YNWAAPFYFPVDPVAlnIPTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFK 555
Cdd:smart00297   4 LQKKLQELLKAVLDKLDsHPLSWPFLKPVSRKE--APDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNART 81

                           90       100
                   ....*....|....*....|....*
gi 2477810793  556 FNIPGDPTYMAGQRFQEIFENKWAQ 580
Cdd:smart00297  82 YNGPDSEVYKDAKKLEKFFEKKLRE 106
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 280-532 1.82e-27

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 114.90  E-value: 1.82e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 280 MTKVQHKFVLKGIQSLKRMNDARFYREPVDPIKMNIPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVT 359
Cdd:COG5076   143 LYADNKAIAKFKKQLFLRDGRFLSSIFLGLPSKREYPDYYEIIKSPMDLLTIQKKLKNGRYKSFEEFVSDLNLMFDNCKL 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 360 FNGPDHLVSQEGLKLKGTFEKQMMNLPKADEVEEKKPKKvstktsaAHREPRTSigtstarptaaspqattfaLGPEGLP 439
Cdd:COG5076   223 YNGPDSSVYVDAKELEKYFLKLIEEIPEEMLELSIKPGR-------EEREERES-------------------VLITNSQ 276

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 440 LIRRDSTnTDGRPKRSIHPPKRD---LPYSTKPKKKKYQWELRFCQEvLDELHKPKHYNWAAPFYFPVDPVALNIPTYHS 516
Cdd:COG5076   277 AHVGAWP-FLRPVSDEEVPDYYKdirDPMDLSTKELKLRNNYYRPEE-TFVRDAKLFFDNCVMYNGEVTDYYKNANVLED 354

                         250
                  ....*....|....*.
gi 2477810793 517 IIKKPMDLSTVQSKLK 532
Cdd:COG5076   355 FVIKKTRLIREYPKLI 370
BROMO smart00297
bromo domain;
282-382 8.00e-26

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 102.36  E-value: 8.00e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793  282 KVQHKFVLKGIQSLKRMND-ARFYREPVDPIKmnIPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTF 360
Cdd:smart00297   5 QKKLQELLKAVLDKLDSHPlSWPFLKPVSRKE--APDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNARTY 82

                           90       100
                   ....*....|....*....|..
gi 2477810793  361 NGPDHLVSQEGLKLKGTFEKQM 382
Cdd:smart00297  83 NGPDSEVYKDAKKLEKFFEKKL 104
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 481-569 1.15e-20

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 86.98  E-value: 1.15e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 481 CQEVLDEL--HKPkhynwAAPFYFPVDPValNIPTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFKFNI 558
Cdd:pfam00439   1 CLEILDKLmeHPI-----AAPFLEPVDPD--EYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNG 73

                          90
                  ....*....|.
gi 2477810793 559 PGDPTYMAGQR 569
Cdd:pfam00439  74 PGSVIYKAAEK 84
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 295-373 5.26e-20

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 85.06  E-value: 5.26e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2477810793 295 LKRMNDARFYREPVDPikMNIPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTFNGPDHLVSQEGLK 373
Cdd:pfam00439   8 LMEHPIAAPFLEPVDP--DEYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVIYKAAEK 84
BET pfam17035
Bromodomain extra-terminal - transcription regulation; The BET, or bromodomain extra-terminal ...
 686-750 5.62e-19

Bromodomain extra-terminal - transcription regulation; The BET, or bromodomain extra-terminal domain, is found on bromodomain proteins that play key roles in development, cancer progression and virus-host pathogenesis. It interacts with NSD3, JMJD6, CHD4, GLTSCR1, and ATAD5 all of which are shown to impart a pTEFb-independent transcriptional activation function on the bromodomain proteins.


Pssm-ID: 435704  Cd Length: 64  Bit Score: 81.39  E-value: 5.62e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2477810793 686 YVTYHEKQIISNGISSLPDKKMQEALKIIQSNVPALKGTQEtEIELDIDELPNEVLLMLLKFVKK 750
Cdd:pfam17035   1 PMTYEEKRELSERINKLPGEKLGRVIEIIKERNPELQSDDD-EIELDIDALDDDTLRKLYNFVKK 64
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2-270 5.30e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 5.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793    2 ATPPPEAPPvvKEDKPQLPPSPNGASSVdvgltstqNHVTEVSPINGTNKPEENDKTATLNCQGTEQLSLTNGAGSTVSP 81
Cdd:PHA03247  2610 GPAPPSPLP--PDTHAPDPPPPSPSPAA--------NEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSP 2679

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793   82 PKSPTEPAdVPAPSGTTATqkeeekpLTSTPADGSDKEPKLENLIPDAPVTQETGSTVGTDQASPQDTKASQDVSKPPTD 161
Cdd:PHA03247  2680 PQRPRRRA-ARPTVGSLTS-------LADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATP 2751

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793  162 sssdakvennvqdsGVKTELPHHPSTSTKLDTMPGDNPTSNAPtvpslqtsdQDMPDAPDAPMSPTKVSRERDADADDEP 241
Cdd:PHA03247  2752 --------------GGPARPARPPTTAGPPAPAPPAAPAAGPP---------RRLTRPAVASLSESRESLPSPWDPADPP 2808

                          250       260
                   ....*....|....*....|....*....
gi 2477810793  242 APKRTKLEDEGSAEVKLPDLPTPVTETPA 270
Cdd:PHA03247  2809 AAVLAPAAALPPAASPAGPLPPPTSAQPT 2837
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 17-244 6.05e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 46.83  E-value: 6.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793  17 PQLPPSPNGASSVDVGLTSTQNHVTEVSPiNGTNkPEENDKTATLNCQgteqlSLTNGAGSTVSPPKSPTEPADVPAPSG 96
Cdd:pfam05109 490 PSPSPRDNGTESKAPDMTSPTSAVTTPTP-NATS-PTPAVTTPTPNAT-----SPTLGKTSPTSAVTTPTPNATSPTPAV 562

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793  97 TTATQKEEEKPLTSTPADGSDKEPKlenliPDA--PVTQETGSTVGTDQASPQDTKASQDVSKPPTDSSSDAKV-ENNVQ 173
Cdd:pfam05109 563 TTPTPNATIPTLGKTSPTSAVTTPT-----PNAtsPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTgQHNIT 637

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2477810793 174 DSGVKTELPHHPSTSTKLDTMPGDNPTSNAPTVPSLQ-TSDQDMPDAPDAPMSPTKVSRErdadaddEPAPK 244
Cdd:pfam05109 638 SSSTSSMSLRPSSISETLSPSTSDNSTSHMPLLTSAHpTGGENITQVTPASTSTHHVSTS-------SPAPR 702
 
Name Accession Description Interval E-value
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 280-382 4.79e-57

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 190.22  E-value: 4.79e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 280 MTKVQHKFVLKGIQSLKRMNDARFYREPVDPIKMNIPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVT 359
Cdd:cd05500     1 MTKHQHKFLLSSIRSLKRLKDARPFLVPVDPVKLNIPHYPTIIKKPMDLGTIERKLKSNVYTSVEEFTADFNLMVDNCLT 80

                          90       100
                  ....*....|....*....|...
gi 2477810793 360 FNGPDHLVSQEGLKLKGTFEKQM 382
Cdd:cd05500    81 FNGPEHPVSQMGKRLQAAFEKHL 103
Bromo_BDF1_2_II cd05499
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast ...
 477-578 5.20e-54

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99931  Cd Length: 102  Bit Score: 181.71  E-value: 5.20e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 477 ELRFCQEVLDELHKPKHYNWAAPFYFPVDPVALNIPTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFKF 556
Cdd:cd05499     1 ELKFCEEVLKELMKPKHSAYNWPFLDPVDPVALNIPNYFSIIKKPMDLGTISKKLQNGQYQSAKEFERDVRLIFKNCYTF 80

                          90       100
                  ....*....|....*....|..
gi 2477810793 557 NIPGDPTYMAGQRFQEIFENKW 578
Cdd:cd05499    81 NPEGTDVYMMGHQLEEVFNDKW 102
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 477-578 8.51e-44

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 153.20  E-value: 8.51e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 477 ELRFCQEVLDELHKPKHYNWAAPFYFPVDPVALNIPTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFKF 556
Cdd:cd05498     1 QLKFCSGILKELFSKKHKAYAWPFYKPVDPEALGLHDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKY 80

                          90       100
                  ....*....|....*....|..
gi 2477810793 557 NIPGDPTYMAGQRFQEIFENKW 578
Cdd:cd05498    81 NPPDHPVHAMARKLQDVFEDRW 102
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 473-575 8.45e-30

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 113.56  E-value: 8.45e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 473 KYQWelRFCQEVLDELHKPKHynwAAPFYFPVDPVALNIPTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKN 552
Cdd:cd05500     3 KHQH--KFLLSSIRSLKRLKD---ARPFLVPVDPVKLNIPHYPTIIKKPMDLGTIERKLKSNVYTSVEEFTADFNLMVDN 77

                          90       100
                  ....*....|....*....|...
gi 2477810793 553 CFKFNIPGDPTYMAGQRFQEIFE 575
Cdd:cd05500    78 CLTFNGPEHPVSQMGKRLQAAFE 100
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 477-578 1.33e-29

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 112.85  E-value: 1.33e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 477 ELRFCQEVLDELHKPKHYNwAAPFYFPVDPvaLNIPTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFKF 556
Cdd:cd04369     1 LKKKLRSLLDALKKLKRDL-SEPFLEPVDP--KEAPDYYEVIKNPMDLSTIKKKLKNGEYKSLEEFEADVRLIFSNAKTY 77

                          90       100
                  ....*....|....*....|..
gi 2477810793 557 NIPGDPTYMAGQRFQEIFENKW 578
Cdd:cd04369    78 NGPGSPIYKDAKKLEKLFEKLL 99
Bromo_plant1 cd05506
Bromodomain, uncharacterized subfamily specific to plants. Might function as a global ...
 481-578 4.10e-29

Bromodomain, uncharacterized subfamily specific to plants. Might function as a global transcription factor. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99938  Cd Length: 99  Bit Score: 111.65  E-value: 4.10e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 481 CQEVLDELHKPKhynWAAPFYFPVDPVALNIPTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFKFNIPG 560
Cdd:cd05506     5 CGTLLRKLMKHK---WGWVFNAPVDVVALGLPDYFDIIKKPMDLGTVKKKLEKGEYSSPEEFAADVRLTFANAMRYNPPG 81

                          90
                  ....*....|....*...
gi 2477810793 561 DPTYMAGQRFQEIFENKW 578
Cdd:cd05506    82 NDVHTMAKELLKIFETRW 99
BROMO smart00297
bromo domain;
477-580 8.42e-29

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 110.83  E-value: 8.42e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793  477 ELRFCQEVLDELHKPKH-YNWAAPFYFPVDPVAlnIPTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFK 555
Cdd:smart00297   4 LQKKLQELLKAVLDKLDsHPLSWPFLKPVSRKE--APDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNART 81

                           90       100
                   ....*....|....*....|....*
gi 2477810793  556 FNIPGDPTYMAGQRFQEIFENKWAQ 580
Cdd:smart00297  82 YNGPDSEVYKDAKKLEKFFEKKLRE 106
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 280-532 1.82e-27

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 114.90  E-value: 1.82e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 280 MTKVQHKFVLKGIQSLKRMNDARFYREPVDPIKMNIPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVT 359
Cdd:COG5076   143 LYADNKAIAKFKKQLFLRDGRFLSSIFLGLPSKREYPDYYEIIKSPMDLLTIQKKLKNGRYKSFEEFVSDLNLMFDNCKL 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 360 FNGPDHLVSQEGLKLKGTFEKQMMNLPKADEVEEKKPKKvstktsaAHREPRTSigtstarptaaspqattfaLGPEGLP 439
Cdd:COG5076   223 YNGPDSSVYVDAKELEKYFLKLIEEIPEEMLELSIKPGR-------EEREERES-------------------VLITNSQ 276

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 440 LIRRDSTnTDGRPKRSIHPPKRD---LPYSTKPKKKKYQWELRFCQEvLDELHKPKHYNWAAPFYFPVDPVALNIPTYHS 516
Cdd:COG5076   277 AHVGAWP-FLRPVSDEEVPDYYKdirDPMDLSTKELKLRNNYYRPEE-TFVRDAKLFFDNCVMYNGEVTDYYKNANVLED 354

                         250
                  ....*....|....*.
gi 2477810793 517 IIKKPMDLSTVQSKLK 532
Cdd:COG5076   355 FVIKKTRLIREYPKLI 370
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 288-382 1.77e-26

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 104.28  E-value: 1.77e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 288 VLKGIQSLKRMNDARFYREPVDPIKMNIPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTFNGPDHLV 367
Cdd:cd05498     8 ILKELFSKKHKAYAWPFYKPVDPEALGLHDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKYNPPDHPV 87

                          90
                  ....*....|....*
gi 2477810793 368 SQEGLKLKGTFEKQM 382
Cdd:cd05498    88 HAMARKLQDVFEDRW 102
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 286-382 2.01e-26

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 103.99  E-value: 2.01e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 286 KFVLKGIQSLKRmNDARFYREPVDPikMNIPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTFNGPDH 365
Cdd:cd04369     6 RSLLDALKKLKR-DLSEPFLEPVDP--KEAPDYYEVIKNPMDLSTIKKKLKNGEYKSLEEFEADVRLIFSNAKTYNGPGS 82

                          90
                  ....*....|....*..
gi 2477810793 366 LVSQEGLKLKGTFEKQM 382
Cdd:cd04369    83 PIYKDAKKLEKLFEKLL 99
BROMO smart00297
bromo domain;
282-382 8.00e-26

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 102.36  E-value: 8.00e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793  282 KVQHKFVLKGIQSLKRMND-ARFYREPVDPIKmnIPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTF 360
Cdd:smart00297   5 QKKLQELLKAVLDKLDSHPlSWPFLKPVSRKE--APDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNARTY 82

                           90       100
                   ....*....|....*....|..
gi 2477810793  361 NGPDHLVSQEGLKLKGTFEKQM 382
Cdd:smart00297  83 NGPDSEVYKDAKKLEKFFEKKL 104
Bromo_BDF1_2_II cd05499
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast ...
 288-382 2.04e-25

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99931  Cd Length: 102  Bit Score: 101.21  E-value: 2.04e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 288 VLKGIQSLKRMNDARFYREPVDPIKMNIPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTFNGPDHLV 367
Cdd:cd05499     8 VLKELMKPKHSAYNWPFLDPVDPVALNIPNYFSIIKKPMDLGTISKKLQNGQYQSAKEFERDVRLIFKNCYTFNPEGTDV 87

                          90
                  ....*....|....*
gi 2477810793 368 SQEGLKLKGTFEKQM 382
Cdd:cd05499    88 YMMGHQLEEVFNDKW 102
Bromo_BAZ2A_B_like cd05503
Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B ...
 477-578 7.61e-25

Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting protein 5) and hWALp3. The proteins may play roles in transcriptional regulation. Human Tip5 is part of a complex termed NoRC (nucleolar remodeling complex), which induces nucleosome sliding and may play a role in the regulation of the rDNA locus. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99935  Cd Length: 97  Bit Score: 99.37  E-value: 7.61e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 477 ELRFCQEVLDELHKpkHYNwAAPFYFPVDPVAlnIPTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFKF 556
Cdd:cd05503     1 DLALCETILDEMEA--HED-AWPFLEPVNTKL--VPGYRKIIKKPMDFSTIREKLESGQYKTLEEFAEDVRLVFDNCETF 75

                          90       100
                  ....*....|....*....|..
gi 2477810793 557 NIPGDPTYMAGQRFQEIFENKW 578
Cdd:cd05503    76 NEDDSEVGRAGHNMRKFFEKRW 97
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 480-577 9.50e-24

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 96.08  E-value: 9.50e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 480 FCQEVLDELHKPKHyNWaaPFYFPVDPvaLNIPTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFKFNIP 559
Cdd:cd05509     5 QLKKVLDSLKNHKS-AW--PFLEPVDK--EEAPDYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDNCRLYNGP 79

                          90
                  ....*....|....*...
gi 2477810793 560 GDPTYMAGQRFQEIFENK 577
Cdd:cd05509    80 DTEYYKCANKLEKFFWKK 97
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 483-580 1.43e-23

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99929  Cd Length: 107  Bit Score: 95.95  E-value: 1.43e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 483 EVLDELHKPKHynwAAPFYFPVDPVALNIPTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFKFNIPGDP 562
Cdd:cd05497    12 VVLKALWKHKF---AWPFQQPVDAVKLNLPDYHKIIKTPMDLGTIKKRLENNYYWSASECIQDFNTMFTNCYIYNKPGDD 88

                          90
                  ....*....|....*...
gi 2477810793 563 TYMAGQRFQEIFENKWAQ 580
Cdd:cd05497    89 VVLMAQTLEKLFLQKLAQ 106
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 304-363 6.70e-23

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99929  Cd Length: 107  Bit Score: 94.03  E-value: 6.70e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 304 YREPVDPIKMNIPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTFNGP 363
Cdd:cd05497    26 FQQPVDAVKLNLPDYHKIIKTPMDLGTIKKRLENNYYWSASECIQDFNTMFTNCYIYNKP 85
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 481-569 1.15e-20

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 86.98  E-value: 1.15e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 481 CQEVLDEL--HKPkhynwAAPFYFPVDPValNIPTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFKFNI 558
Cdd:pfam00439   1 CLEILDKLmeHPI-----AAPFLEPVDPD--EYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNG 73

                          90
                  ....*....|.
gi 2477810793 559 PGDPTYMAGQR 569
Cdd:pfam00439  74 PGSVIYKAAEK 84
Bromo_cbp_like cd05495
Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase ...
 478-576 1.45e-20

Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to phosphorylated CREB protein and augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99927  Cd Length: 108  Bit Score: 87.50  E-value: 1.45e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 478 LRFCQEVLDELHKPKHYnwAAPFYFPVDPVALNIPTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFKFN 557
Cdd:cd05495     5 RQALMPTLEKLYKQDPE--SLPFRQPVDPKLLGIPDYFDIVKNPMDLSTIRRKLDTGQYQDPWQYVDDVWLMFDNAWLYN 82

                          90
                  ....*....|....*....
gi 2477810793 558 IPGDPTYMAGQRFQEIFEN 576
Cdd:cd05495    83 RKTSRVYKYCTKLAEVFEQ 101
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 292-385 1.69e-20

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 86.84  E-value: 1.69e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 292 IQSLKRMNDARFYREPVDpiKMNIPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTFNGPDHLVSQEG 371
Cdd:cd05509    10 LDSLKNHKSAWPFLEPVD--KEEAPDYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDNCRLYNGPDTEYYKCA 87

                          90
                  ....*....|....
gi 2477810793 372 LKLKGTFEKQMMNL 385
Cdd:cd05509    88 NKLEKFFWKKLKEL 101
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 295-373 5.26e-20

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 85.06  E-value: 5.26e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2477810793 295 LKRMNDARFYREPVDPikMNIPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTFNGPDHLVSQEGLK 373
Cdd:pfam00439   8 LMEHPIAAPFLEPVDP--DEYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVIYKAAEK 84
Bromo_cbp_like cd05495
Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase ...
 295-382 2.20e-19

Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to phosphorylated CREB protein and augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99927  Cd Length: 108  Bit Score: 84.03  E-value: 2.20e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 295 LKRMNDARFYREPVDPIKMNIPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTFNGPDHLVSQEGLKL 374
Cdd:cd05495    16 YKQDPESLPFRQPVDPKLLGIPDYFDIVKNPMDLSTIRRKLDTGQYQDPWQYVDDVWLMFDNAWLYNRKTSRVYKYCTKL 95


                  ....*...
gi 2477810793 375 KGTFEKQM 382
Cdd:cd05495    96 AEVFEQEI 103
Bromo_plant1 cd05506
Bromodomain, uncharacterized subfamily specific to plants. Might function as a global ...
 304-380 2.67e-19

Bromodomain, uncharacterized subfamily specific to plants. Might function as a global transcription factor. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99938  Cd Length: 99  Bit Score: 83.53  E-value: 2.67e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2477810793 304 YREPVDPIKMNIPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTFNGPDHLVSQEGLKLKGTFEK 380
Cdd:cd05506    21 FNAPVDVVALGLPDYFDIIKKPMDLGTVKKKLEKGEYSSPEEFAADVRLTFANAMRYNPPGNDVHTMAKELLKIFET 97
BET pfam17035
Bromodomain extra-terminal - transcription regulation; The BET, or bromodomain extra-terminal ...
 686-750 5.62e-19

Bromodomain extra-terminal - transcription regulation; The BET, or bromodomain extra-terminal domain, is found on bromodomain proteins that play key roles in development, cancer progression and virus-host pathogenesis. It interacts with NSD3, JMJD6, CHD4, GLTSCR1, and ATAD5 all of which are shown to impart a pTEFb-independent transcriptional activation function on the bromodomain proteins.


Pssm-ID: 435704  Cd Length: 64  Bit Score: 81.39  E-value: 5.62e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2477810793 686 YVTYHEKQIISNGISSLPDKKMQEALKIIQSNVPALKGTQEtEIELDIDELPNEVLLMLLKFVKK 750
Cdd:pfam17035   1 PMTYEEKRELSERINKLPGEKLGRVIEIIKERNPELQSDDD-EIELDIDALDDDTLRKLYNFVKK 64
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 330-575 2.09e-18

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 87.94  E-value: 2.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 330 TIERKLKNNEYKTAQAVVDDFNlmvqnavtFNGPDHLVSQEGLKLKGTFEKQMMNLPKadEVEEKKPKKVSTKTSAAHRE 409
Cdd:COG5076     9 SQLGRPSVLKEEFGNELLRLVD--------NDSSPFPNAPEEEGSKNLFQKQLKRMPK--EYITSIVDDREPGSMANVND 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 410 PRTSIGTSTARPT-AASPQATTFALGPEgLPLIRRDSTNTDGRPKRSIHPPKRDLPYSTKPKKKKYQWELRFCQEVLDEL 488
Cdd:COG5076    79 DLENVGGITYSPFeKNRPESLRFDEIVF-LAIESVTPESGLGSLLMAHLKTSVKKRKTPKIEDELLYADNKAIAKFKKQL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 489 HKPKHYNwaAPFYFPVDPVALNIPTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFKFNIPGDPTYMAGQ 568
Cdd:COG5076   158 FLRDGRF--LSSIFLGLPSKREYPDYYEIIKSPMDLLTIQKKLKNGRYKSFEEFVSDLNLMFDNCKLYNGPDSSVYVDAK 235


                  ....*..
gi 2477810793 569 RFQEIFE 575
Cdd:COG5076   236 ELEKYFL 242
Bromo_Acf1_like cd05504
Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was ...
 477-577 9.16e-18

Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) and regulates ISWI-induced nucleosome remodeling. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99936  Cd Length: 115  Bit Score: 79.75  E-value: 9.16e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 477 ELRFCQEVLDELHKPKHyNWaaPFYFPVDpvALNIPTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFKF 556
Cdd:cd05504    13 NLSALEQLLVEIVKHKD-SW--PFLRPVS--KIEVPDYYDIIKKPMDLGTIKEKLNMGEYKLAEEFLSDIQLVFSNCFLY 87

                          90       100
                  ....*....|....*....|.
gi 2477810793 557 NIPGDPTYMAGQRFQEIFENK 577
Cdd:cd05504    88 NPEHTSVYKAGTRLQRFFIKR 108
Bromo_tif1_like cd05502
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of ...
 477-577 1.64e-17

Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or corepressors to modulate transcription. Vertebrate Tif1-gamma, also labeled E3 ubiquitin-protein ligase TRIM33, plays a role in the control of hematopoiesis. Its homologue in Xenopus laevis, Ectodermin, has been shown to function in germ-layer specification and control of cell growth during embryogenesis. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99934 [Multi-domain]  Cd Length: 109  Bit Score: 78.87  E-value: 1.64e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 477 ELRFCQEVLDEL--HKPkhynwAAPFYFPVDPvalNIPTYHSIIKKPMDLSTVQSKLK---TGQYENAKEFEVDMRQIFK 551
Cdd:cd05502     5 DQRKCERLLLELycHEL-----SLPFHEPVSP---SVPNYYKIIKTPMDLSLIRKKLQpksPQHYSSPEEFVADVRLMFK 76

                          90       100
                  ....*....|....*....|....*.
gi 2477810793 552 NCFKFNIPGDPTYMAGQRFQEIFENK 577
Cdd:cd05502    77 NCYKFNEEDSEVAQAGKELELFFEEQ 102
Bromo_tif1_like cd05502
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of ...
 304-382 2.86e-17

Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or corepressors to modulate transcription. Vertebrate Tif1-gamma, also labeled E3 ubiquitin-protein ligase TRIM33, plays a role in the control of hematopoiesis. Its homologue in Xenopus laevis, Ectodermin, has been shown to function in germ-layer specification and control of cell growth during embryogenesis. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99934 [Multi-domain]  Cd Length: 109  Bit Score: 78.10  E-value: 2.86e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 304 YREPVDPIkmnIPHYPQIIKHPMDLGTIERKLKNNE---YKTAQAVVDDFNLMVQNAVTFNGPDHLVSQEGLKLKGTFEK 380
Cdd:cd05502    25 FHEPVSPS---VPNYYKIIKTPMDLSLIRKKLQPKSpqhYSSPEEFVADVRLMFKNCYKFNEEDSEVAQAGKELELFFEE 101


                  ..
gi 2477810793 381 QM 382
Cdd:cd05502   102 QL 103
Bromo_TFIID cd05511
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, ...
 484-575 5.56e-17

Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99943 [Multi-domain]  Cd Length: 112  Bit Score: 77.30  E-value: 5.56e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 484 VLDELH-KPKHYNWAAPFYFPVDPValNIPTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFKFNIPGDP 562
Cdd:cd05511     4 ILDEIVnELKNLPDSWPFHTPVNKK--KVPDYYKIIKRPMDLQTIRKKISKHKYQSREEFLEDIELIVDNSVLYNGPDSV 81

                          90
                  ....*....|....
gi 2477810793 563 -TYMAgqrfQEIFE 575
Cdd:cd05511    82 yTKKA----KEMLE 91
Bromo_SPT7_like cd05510
Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the ...
 481-557 3.44e-16

Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, and SLIK. SAGA is involved in the RNA polymerase II-dependent transcriptional regulation of about 10% of all yeast genes. The SPT7 bromodomain has been shown to weakly interact with acetylated histone H3, but not H4. The human representative of this subfamily is cat eye syndrome critical region protein 2 (CECR2). Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99942 [Multi-domain]  Cd Length: 112  Bit Score: 75.17  E-value: 3.44e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2477810793 481 CQEVLDELHKpkHYNWAAPFYFPVDPValNIPTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFKFN 557
Cdd:cd05510    12 LDKVLNELKT--YTEHSTPFLTKVSKR--EAPDYYDIIKKPMDLGTMLKKLKNLQYKSKAEFVDDLNLIWKNCLLYN 84
Bromo_TFIID cd05511
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, ...
 287-388 7.75e-15

Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99943 [Multi-domain]  Cd Length: 112  Bit Score: 71.14  E-value: 7.75e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 287 FVL-KGIQSLKRMNDARFYREPVDPIKmnIPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTFNGPDH 365
Cdd:cd05511     3 FILdEIVNELKNLPDSWPFHTPVNKKK--VPDYYKIIKRPMDLQTIRKKISKHKYQSREEFLEDIELIVDNSVLYNGPDS 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 2477810793 366 ---LVSQEGLKLKGT----FEKQMMNLPKA 388
Cdd:cd05511    81 vytKKAKEMLELAEEllaeREEKLTQLEKN 110
Bromo_AAA cd05528
Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long ...
 477-562 1.43e-14

Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this alignment is an uncharacterized protein predicted from analysis of cDNA clones from human fetal liver


Pssm-ID: 99957  Cd Length: 112  Bit Score: 70.46  E-value: 1.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 477 ELRFC-QEVLDELHKPKHYNwaaPFYFPVDPValNIPTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFK 555
Cdd:cd05528     3 ELRLFlRDVLKRLASDKRFN---AFTKPVDEE--EVPDYYEIIKQPMDLQTILQKLDTHQYLTAKDFLKDIDLIVTNALE 77


                  ....*..
gi 2477810793 556 FNIPGDP 562
Cdd:cd05528    78 YNPDRDP 84
Bromo_brd1_like cd05512
Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein ...
 295-375 2.91e-14

Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99944  Cd Length: 98  Bit Score: 68.97  E-value: 2.91e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 295 LKRMNDARFYREPVDpIKmNIPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTFNGPDHLVSQEGLKL 374
Cdd:cd05512    13 LQEKDTAEIFSEPVD-LS-EVPDYLDHIKQPMDFSTMRKKLESQRYRTLEDFEADFNLIINNCLAYNAKDTIFYRAAVRL 90


                  .
gi 2477810793 375 K 375
Cdd:cd05512    91 R 91
Bromo_polybromo_V cd05515
Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which ...
 310-374 8.11e-14

Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99946  Cd Length: 105  Bit Score: 68.10  E-value: 8.11e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2477810793 310 PIKMNIPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTFNGPDHLVSQEGLKL 374
Cdd:cd05515    31 PSKSEYPDYYDVIKKPIDMEKIRSKIEGNQYQSLDDMVSDFVLMFDNACKYNEPDSQIYKDALTL 95
Bromo_Acf1_like cd05504
Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was ...
 295-386 1.09e-13

Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) and regulates ISWI-induced nucleosome remodeling. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99936  Cd Length: 115  Bit Score: 68.19  E-value: 1.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 295 LKRMNDARFYREPVDpiKMNIPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTFNGPDHLVSQEGLKL 374
Cdd:cd05504    24 IVKHKDSWPFLRPVS--KIEVPDYYDIIKKPMDLGTIKEKLNMGEYKLAEEFLSDIQLVFSNCFLYNPEHTSVYKAGTRL 101

                          90
                  ....*....|....
gi 2477810793 375 KGTFEKQM--MNLP 386
Cdd:cd05504   102 QRFFIKRCrkLGLP 115
Bromo_BAZ2A_B_like cd05503
Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B ...
 300-380 5.45e-13

Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting protein 5) and hWALp3. The proteins may play roles in transcriptional regulation. Human Tip5 is part of a complex termed NoRC (nucleolar remodeling complex), which induces nucleosome sliding and may play a role in the regulation of the rDNA locus. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99935  Cd Length: 97  Bit Score: 65.47  E-value: 5.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 300 DARFYREPVDPikMNIPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTFNGPDHLVSQEGLKLKGTFE 379
Cdd:cd05503    17 DAWPFLEPVNT--KLVPGYRKIIKKPMDFSTIREKLESGQYKTLEEFAEDVRLVFDNCETFNEDDSEVGRAGHNMRKFFE 94


                  .
gi 2477810793 380 K 380
Cdd:cd05503    95 K 95
Bromo_brd7_like cd05513
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown ...
 292-382 9.60e-13

Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene involved in nasopharyngeal carcinoma. The protein interacts with acetylated histone H3 via its bromodomain. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99945  Cd Length: 98  Bit Score: 64.74  E-value: 9.60e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 292 IQSLKRMNDARFYREPV-DPIKmniPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTFNGPDHLVSQE 370
Cdd:cd05513    10 IRQLQRKDPHGFFAFPVtDFIA---PGYSSIIKHPMDFSTMKEKIKNNDYQSIEEFKDDFKLMCENAMKYNKPDTIYYKA 86

                          90
                  ....*....|..
gi 2477810793 371 GLKLKGTFEKQM 382
Cdd:cd05513    87 AKKLLHSGMKIL 98
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 289-364 1.07e-12

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99958  Cd Length: 128  Bit Score: 65.82  E-value: 1.07e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2477810793 289 LKGIQSLKRMNDARFYREPVDpIKMNIPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTFNGPD 364
Cdd:cd05529    33 LDKLLLSLQLEIAEYFEYPVD-LRAWYPDYWNRVPVPMDLETIRSRLENRYYRSLEALRHDVRLILSNAETFNEPN 107
Bromo_SPT7_like cd05510
Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the ...
 312-386 1.25e-12

Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, and SLIK. SAGA is involved in the RNA polymerase II-dependent transcriptional regulation of about 10% of all yeast genes. The SPT7 bromodomain has been shown to weakly interact with acetylated histone H3, but not H4. The human representative of this subfamily is cat eye syndrome critical region protein 2 (CECR2). Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99942 [Multi-domain]  Cd Length: 112  Bit Score: 65.16  E-value: 1.25e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2477810793 312 KMNIPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTFNG-PDHLVSQEGLKLKGTFEKQMMNLP 386
Cdd:cd05510    35 KREAPDYYDIIKKPMDLGTMLKKLKNLQYKSKAEFVDDLNLIWKNCLLYNSdPSHPLRRHANFMKKKAEHLLKLIP 110
Bromo_brd7_like cd05513
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown ...
 482-569 2.22e-12

Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene involved in nasopharyngeal carcinoma. The protein interacts with acetylated histone H3 via its bromodomain. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99945  Cd Length: 98  Bit Score: 63.97  E-value: 2.22e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 482 QEVLDELHKP-KHYNWAAPFYFPV-DPVAlniPTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFKFNIP 559
Cdd:cd05513     3 QKALEQLIRQlQRKDPHGFFAFPVtDFIA---PGYSSIIKHPMDFSTMKEKIKNNDYQSIEEFKDDFKLMCENAMKYNKP 79

                          90
                  ....*....|
gi 2477810793 560 GDPTYMAGQR 569
Cdd:cd05513    80 DTIYYKAAKK 89
Bromo_WSTF_like cd05505
Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The ...
 477-560 4.40e-12

Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two chromatin remodeling complexes, WINAC and WICH. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99937  Cd Length: 97  Bit Score: 62.94  E-value: 4.40e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 477 ELRFCQEVLDELHKpkhYNWAAPFYFPvdPVALNIPTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFKF 556
Cdd:cd05505     1 ELQKCEEILSKILK---YRFSWPFREP--VTADEAEDYKKVITNPMDLQTMQTKCSCGSYSSVQEFLDDMKLVFSNAEKY 75


                  ....
gi 2477810793 557 NIPG 560
Cdd:cd05505    76 YENG 79
Bromo_brd1_like cd05512
Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein ...
 505-572 7.93e-12

Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99944  Cd Length: 98  Bit Score: 62.03  E-value: 7.93e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2477810793 505 DPVALN-IPTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFKFNIPGDPTYMAGQRFQE 572
Cdd:cd05512    24 EPVDLSeVPDYLDHIKQPMDFSTMRKKLESQRYRTLEDFEADFNLIINNCLAYNAKDTIFYRAAVRLRD 92
Bromo_WDR9_II cd05496
Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 497-577 1.85e-11

Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99928  Cd Length: 119  Bit Score: 61.70  E-value: 1.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 497 AAPFYFPVDPVALniPTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFKFNiPGDPT--YMAGQRFQEIF 574
Cdd:cd05496    23 SEPFRQPVDLLKY--PDYRDIIDTPMDLGTVKETLFGGNYDDPMEFAKDVRLIFSNSKSYT-PNKRSriYSMTLRLSALF 99


                  ...
gi 2477810793 575 ENK 577
Cdd:cd05496   100 EEH 102
Bromo_polybromo_IV cd05518
Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which ...
 305-361 3.81e-11

Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99949 [Multi-domain]  Cd Length: 103  Bit Score: 60.54  E-value: 3.81e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2477810793 305 REPVD-----PIKMNIPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTFN 361
Cdd:cd05518    21 RRLCDlfmekPSKKDYPDYYKIILEPIDLKTIEHNIRNDKYATEEELMDDFKLMFRNARHYN 82
Bromo_SNF2 cd05519
Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in ...
 310-380 6.68e-11

Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in transcriptional activation, it is the catalytic component of the SWI/SNF ATP-dependent chromatin remodeling complex. The protein is essential for the regulation of gene expression (both positive and negative) of a large number of genes. The SWI/SNF complex changes chromatin structure by altering DNA-histone contacts within the nucleosome, which results in a re-positioning of the nucleosome and facilitates or represses the binding of gene-specific transcription factors. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99950  Cd Length: 103  Bit Score: 59.66  E-value: 6.68e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2477810793 310 PIKMNIPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTFNGPDHLVSQEGLKLKGTFEK 380
Cdd:cd05519    31 PSKKLYPDYYVIIKRPIALDQIKRRIEGRAYKSLEEFLEDFHLMFANARTYNQEGSIVYEDAVEMEKAFKK 101
Bromo_Rsc1_2_II cd05522
Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 286-385 8.25e-11

Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99953 [Multi-domain]  Cd Length: 104  Bit Score: 59.56  E-value: 8.25e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 286 KFVLKGIQSLKRMND----ARFYREPvDPIKMniPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTFN 361
Cdd:cd05522     7 KNILKGLRKERDENGrlltLHFEKLP-DKARE--PEYYQEISNPISLDDIKKKVKRRKYKSFDQFLNDLNLMFENAKLYN 83

                          90       100
                  ....*....|....*....|....
gi 2477810793 362 GPDhlvSQEgLKLKGTFEKQMMNL 385
Cdd:cd05522    84 END---SQE-YKDAVLLEKEARLL 103
Bromo_SNF2L2 cd05516
Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI ...
 310-382 1.12e-10

Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone receptors to boost transcriptional activation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99947  Cd Length: 107  Bit Score: 59.36  E-value: 1.12e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2477810793 310 PIKMNIPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTFNGPDHLVSQEGLKLKGTFEKQM 382
Cdd:cd05516    32 PSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLEDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFKSAR 104
Bromo_AAA cd05528
Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long ...
 288-364 1.60e-10

Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this alignment is an uncharacterized protein predicted from analysis of cDNA clones from human fetal liver


Pssm-ID: 99957  Cd Length: 112  Bit Score: 58.91  E-value: 1.60e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2477810793 288 VLKGIQSLKRMNDarFYRePVDPikMNIPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTFNGPD 364
Cdd:cd05528    11 VLKRLASDKRFNA--FTK-PVDE--EEVPDYYEIIKQPMDLQTILQKLDTHQYLTAKDFLKDIDLIVTNALEYNPDR 82
Bromo_polybromo_V cd05515
Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which ...
 512-565 2.46e-10

Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99946  Cd Length: 105  Bit Score: 58.08  E-value: 2.46e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2477810793 512 PTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFKFNIPGDPTYM 565
Cdd:cd05515    37 PDYYDVIKKPIDMEKIRSKIEGNQYQSLDDMVSDFVLMFDNACKYNEPDSQIYK 90
Bromo_polybromo_III cd05520
Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which ...
 512-577 3.20e-10

Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99951  Cd Length: 103  Bit Score: 57.73  E-value: 3.20e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2477810793 512 PTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFKFNIPGDPTYMAGQRFQEIFENK 577
Cdd:cd05520    37 PDYYQEIKNPISLQQIRTKLKNGEYETLEELEADLNLMFENAKRYNVPNSRIYKDAEKLQKLMQAK 102
Bromo_polybromo_III cd05520
Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which ...
 310-375 4.41e-10

Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99951  Cd Length: 103  Bit Score: 57.35  E-value: 4.41e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2477810793 310 PIKMNIPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTFNGPDHLVSQEGLKLK 375
Cdd:cd05520    31 PSKRKYPDYYQEIKNPISLQQIRTKLKNGEYETLEELEADLNLMFENAKRYNVPNSRIYKDAEKLQ 96
Bromo_polybromo_I cd05524
Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which ...
 310-381 1.14e-09

Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99954 [Multi-domain]  Cd Length: 113  Bit Score: 56.57  E-value: 1.14e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2477810793 310 PIKMNIPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTFNGPDHLVSQEGLKLKGTFEKQ 381
Cdd:cd05524    33 PKRRNEPEYYEVVSNPIDLLKIQQKLKTEEYDDVDDLTADFELLINNAKAYYKPDSPEHKDACKLWELFLSA 104
Bromo_ASH1 cd05525
Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the ...
 506-576 1.51e-09

Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in histones H3 and H4. Mammalian ASH1 has been shown to methylate histone H3. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99955 [Multi-domain]  Cd Length: 106  Bit Score: 55.86  E-value: 1.51e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2477810793 506 PVALNIPTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFKFNIPGDPTYMAGQRFQEIFEN 576
Cdd:cd05525    33 PSKKKNPDYYERITDPVDLSTIEKQILTGYYKTPEAFDSDMLKVFRNAEKYYGRKSPIGRDVCRLRKAYYQ 103
Bromo_polybromo_I cd05524
Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which ...
 512-589 1.85e-09

Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99954 [Multi-domain]  Cd Length: 113  Bit Score: 55.80  E-value: 1.85e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2477810793 512 PTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFKFNIPGDPTYMAGQRFQEIFEnkwAQKTRYLEAHE 589
Cdd:cd05524    39 PEYYEVVSNPIDLLKIQQKLKTEEYDDVDDLTADFELLINNAKAYYKPDSPEHKDACKLWELFL---SARNEVLSGGE 113
Bromo_polybromo_II cd05517
Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which ...
 310-378 1.00e-08

Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99948  Cd Length: 103  Bit Score: 53.60  E-value: 1.00e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2477810793 310 PIKMNIPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTFNGPDHLVSQEGLKLKGTF 378
Cdd:cd05517    31 PSKVLYPDYYAVIKEPIDLKTIAQRIQSGYYKSIEDMEKDLDLMVKNAKTFNEPGSQVYKDANAIKKIF 99
Bromo_SP100C_like cd05501
Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major ...
 315-380 1.64e-08

Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin level. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99933  Cd Length: 102  Bit Score: 52.82  E-value: 1.64e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2477810793 315 IPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTFNGPDHLVsQEGLKLKGTFEK 380
Cdd:cd05501    30 IRDYCQGIKEPMWLNKVKERLNERVYHTVEGFVRDMRLIFHNHKLFYKDDDFG-QVGITLEKKFEK 94
Bromo_RACK7 cd05508
Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) ...
 294-369 3.18e-08

Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular proliferation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99940  Cd Length: 99  Bit Score: 52.00  E-value: 3.18e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2477810793 294 SLKRM--NDARFYREPVDpiKMNIPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTFNGPDHLVSQ 369
Cdd:cd05508    11 ALERMkqPGAEPFLKPVD--LEQFPDYAQYVFKPMDLSTLEKNVRKKAYGSTDAFLADAKWILHNAIIYNGGDHKLTQ 86
Bromo_brd8_like cd05507
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with ...
 316-368 3.29e-08

Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be a nuclear receptor coactivator. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99939  Cd Length: 104  Bit Score: 51.98  E-value: 3.29e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2477810793 316 PHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTFNGPDHLVS 368
Cdd:cd05507    34 PGYHSVVYRPMDLSTIKKNIENGTIRSTAEFQRDVLLMFQNAIMYNSSDHDVY 86
Bromo_WDR9_II cd05496
Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 300-361 7.19e-08

Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99928  Cd Length: 119  Bit Score: 51.69  E-value: 7.19e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2477810793 300 DARFYREPVDPIKMniPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTFN 361
Cdd:cd05496    22 DSEPFRQPVDLLKY--PDYRDIIDTPMDLGTVKETLFGGNYDDPMEFAKDVRLIFSNSKSYT 81
Bromo_WSTF_like cd05505
Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The ...
 292-369 7.57e-08

Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two chromatin remodeling complexes, WINAC and WICH. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99937  Cd Length: 97  Bit Score: 51.00  E-value: 7.57e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2477810793 292 IQSLKRMNDARFYREPvdPIKMNIPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTFNGPDHLVSQ 369
Cdd:cd05505     9 LSKILKYRFSWPFREP--VTADEAEDYKKVITNPMDLQTMQTKCSCGSYSSVQEFLDDMKLVFSNAEKYYENGSYVLS 84
Bromo_ASH1 cd05525
Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the ...
 310-381 9.70e-08

Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in histones H3 and H4. Mammalian ASH1 has been shown to methylate histone H3. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99955 [Multi-domain]  Cd Length: 106  Bit Score: 50.85  E-value: 9.70e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2477810793 310 PIKMNIPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTFNGPDHLVSQEGLKLKGTFEKQ 381
Cdd:cd05525    33 PSKKKNPDYYERITDPVDLSTIEKQILTGYYKTPEAFDSDMLKVFRNAEKYYGRKSPIGRDVCRLRKAYYQA 104
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 485-560 1.03e-07

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99958  Cd Length: 128  Bit Score: 51.57  E-value: 1.03e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2477810793 485 LDELHKPKHYNWAAPFYFPVDpVALNIPTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFKFNIPG 560
Cdd:cd05529    33 LDKLLLSLQLEIAEYFEYPVD-LRAWYPDYWNRVPVPMDLETIRSRLENRYYRSLEALRHDVRLILSNAETFNEPN 107
Bromo_Rsc1_2_I cd05521
Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 310-376 1.21e-07

Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99952  Cd Length: 106  Bit Score: 50.40  E-value: 1.21e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2477810793 310 PIKMNIPHYPQIIKHPMDLGTIERKLKNneYKTAQAVVDDFNLMVQNAVTFNGPDHLVSQEGLKLKG 376
Cdd:cd05521    32 PLRKDYPDYYKIIKNPLSLNTVKKRLPH--YTNAQEFVNDLAQIPWNARLYNTKGSVIYKYALILEK 96
Bromo_brd8_like cd05507
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with ...
 496-568 2.30e-07

Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be a nuclear receptor coactivator. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99939  Cd Length: 104  Bit Score: 49.67  E-value: 2.30e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2477810793 496 WAAPFYFPV-DPVAlniPTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFKFNIPGDPTY-MAGQ 568
Cdd:cd05507    20 YASVFLKPVtEDIA---PGYHSVVYRPMDLSTIKKNIENGTIRSTAEFQRDVLLMFQNAIMYNSSDHDVYlMAVE 91
Bromo_SNF2L2 cd05516
Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI ...
 511-574 5.52e-07

Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone receptors to boost transcriptional activation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99947  Cd Length: 107  Bit Score: 48.58  E-value: 5.52e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2477810793 511 IPTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFKFNIPGDPTYMAGQRFQEIF 574
Cdd:cd05516    37 LPEYYELIRKPVDFKKIKERIRNHKYRSLEDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVF 100
Bromo_SP100C_like cd05501
Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major ...
 511-575 5.60e-07

Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin level. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99933  Cd Length: 102  Bit Score: 48.58  E-value: 5.60e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2477810793 511 IPTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFKFNIPGDPTYMaGQRFQEIFE 575
Cdd:cd05501    30 IRDYCQGIKEPMWLNKVKERLNERVYHTVEGFVRDMRLIFHNHKLFYKDDDFGQV-GITLEKKFE 93
Bromo_Rsc1_2_II cd05522
Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 512-571 1.01e-06

Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99953 [Multi-domain]  Cd Length: 104  Bit Score: 48.01  E-value: 1.01e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 512 PTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFKFNIPGDPTYMAGQRFQ 571
Cdd:cd05522    38 PEYYQEISNPISLDDIKKKVKRRKYKSFDQFLNDLNLMFENAKLYNENDSQEYKDAVLLE 97
Bromo_polybromo_IV cd05518
Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which ...
 502-564 1.08e-06

Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99949 [Multi-domain]  Cd Length: 103  Bit Score: 47.83  E-value: 1.08e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2477810793 502 FPVDPVALNIPTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFKFNIPGDPTY 564
Cdd:cd05518    27 FMEKPSKKDYPDYYKIILEPIDLKTIEHNIRNDKYATEEELMDDFKLMFRNARHYNEEGSQVY 89
Bromo_Rsc1_2_I cd05521
Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 502-564 8.91e-06

Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99952  Cd Length: 106  Bit Score: 45.39  E-value: 8.91e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2477810793 502 FPVDPVALNIPTYHSIIKKPMDLSTVQSKLKtgQYENAKEFEVDMRQIFKNCFKFNIPGDPTY 564
Cdd:cd05521    28 FNVLPLRKDYPDYYKIIKNPLSLNTVKKRLP--HYTNAQEFVNDLAQIPWNARLYNTKGSVIY 88
Bromo_RACK7 cd05508
Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) ...
 494-557 1.31e-05

Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular proliferation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99940  Cd Length: 99  Bit Score: 44.68  E-value: 1.31e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2477810793 494 YNWAAPFYFPVDpvALNIPTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFKFN 557
Cdd:cd05508    17 QPGAEPFLKPVD--LEQFPDYAQYVFKPMDLSTLEKNVRKKAYGSTDAFLADAKWILHNAIIYN 78
Bromo_ZMYND11 cd05492
Bromodomain; ZMYND11_like sub-family. ZMYND11 or BS69 is a ubiquitously expressed nuclear ...
 286-371 2.07e-05

Bromodomain; ZMYND11_like sub-family. ZMYND11 or BS69 is a ubiquitously expressed nuclear protein that has been shown to associate with chromatin. It interacts with chromatin remodeling factors and might play a role in chromatin remodeling and gene expression. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99924  Cd Length: 109  Bit Score: 44.29  E-value: 2.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 286 KFVLKGIQSLKRMNDArfYREPV---DPIKMNIPHYPQIIKHPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTFNG 362
Cdd:cd05492     6 KFIVSRMKSWLPPDTT--NRAIVlnkRGKATKLPKRRRLIHTHLDVADIQEKINSEKYTSLEEFKADALLLLHNTAIFHG 83


                  ....*....
gi 2477810793 363 PDhlvSQEG 371
Cdd:cd05492    84 AD---SEQY 89
Bromodomain_1 cd05494
Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated ...
 481-526 3.40e-05

Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99926 [Multi-domain]  Cd Length: 114  Bit Score: 43.97  E-value: 3.40e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2477810793 481 CQEVLDELHKPKHYNWAAPFYFPVDPVALNIPTYHSIIKKPMDLST 526
Cdd:cd05494     5 LERVLRELKRHRRNEDAWPFLEPVNPPRRGAPDYRDVIKRPMSFGT 50
Bromo_polybromo_II cd05517
Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which ...
 512-564 4.68e-05

Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99948  Cd Length: 103  Bit Score: 43.20  E-value: 4.68e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2477810793 512 PTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKNCFKFNIPGDPTY 564
Cdd:cd05517    37 PDYYAVIKEPIDLKTIAQRIQSGYYKSIEDMEKDLDLMVKNAKTFNEPGSQVY 89
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2-270 5.30e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 5.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793    2 ATPPPEAPPvvKEDKPQLPPSPNGASSVdvgltstqNHVTEVSPINGTNKPEENDKTATLNCQGTEQLSLTNGAGSTVSP 81
Cdd:PHA03247  2610 GPAPPSPLP--PDTHAPDPPPPSPSPAA--------NEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSP 2679

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793   82 PKSPTEPAdVPAPSGTTATqkeeekpLTSTPADGSDKEPKLENLIPDAPVTQETGSTVGTDQASPQDTKASQDVSKPPTD 161
Cdd:PHA03247  2680 PQRPRRRA-ARPTVGSLTS-------LADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATP 2751

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793  162 sssdakvennvqdsGVKTELPHHPSTSTKLDTMPGDNPTSNAPtvpslqtsdQDMPDAPDAPMSPTKVSRERDADADDEP 241
Cdd:PHA03247  2752 --------------GGPARPARPPTTAGPPAPAPPAAPAAGPP---------RRLTRPAVASLSESRESLPSPWDPADPP 2808

                          250       260
                   ....*....|....*....|....*....
gi 2477810793  242 APKRTKLEDEGSAEVKLPDLPTPVTETPA 270
Cdd:PHA03247  2809 AAVLAPAAALPPAASPAGPLPPPTSAQPT 2837
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 17-244 6.05e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 46.83  E-value: 6.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793  17 PQLPPSPNGASSVDVGLTSTQNHVTEVSPiNGTNkPEENDKTATLNCQgteqlSLTNGAGSTVSPPKSPTEPADVPAPSG 96
Cdd:pfam05109 490 PSPSPRDNGTESKAPDMTSPTSAVTTPTP-NATS-PTPAVTTPTPNAT-----SPTLGKTSPTSAVTTPTPNATSPTPAV 562

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793  97 TTATQKEEEKPLTSTPADGSDKEPKlenliPDA--PVTQETGSTVGTDQASPQDTKASQDVSKPPTDSSSDAKV-ENNVQ 173
Cdd:pfam05109 563 TTPTPNATIPTLGKTSPTSAVTTPT-----PNAtsPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTgQHNIT 637

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2477810793 174 DSGVKTELPHHPSTSTKLDTMPGDNPTSNAPTVPSLQ-TSDQDMPDAPDAPMSPTKVSRErdadaddEPAPK 244
Cdd:pfam05109 638 SSSTSSMSLRPSSISETLSPSTSDNSTSHMPLLTSAHpTGGENITQVTPASTSTHHVSTS-------SPAPR 702
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2-271 1.28e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 1.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793    2 ATPPPEAPPVVKEDKPQLPPSPNGASSVDVGLTSTQNhVTEVSPINGTNKPEENDKTATLNCQGTEQLSLTNGAGSTVSP 81
Cdd:PHA03247  2687 AARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPP-GPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAG 2765

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793   82 PKSPTEPADVPAPSGTTATQKEEEKPLTSTPADGSDKEPKLENLIPDAPVTQETGSTVGTDQASPQDTKASQDVSKPPTD 161
Cdd:PHA03247  2766 PPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGP 2845

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793  162 SSSDAKVENNVQDSGVKTELPHHPSTSTKLDTMPgdNPTSNAPTVPSLQTSDQDMPDAPDAPmsptkvSRERDADADDEP 241
Cdd:PHA03247  2846 PPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPA--RPPVRRLARPAVSRSTESFALPPDQP------ERPPQPQAPPPP 2917

                          250       260       270
                   ....*....|....*....|....*....|
gi 2477810793  242 APKrtkledegsAEVKLPDLPTPVTETPAR 271
Cdd:PHA03247  2918 QPQ---------PQPPPPPQPQPPPPPPPR 2938
Bromo_TBP7_like cd05491
Bromodomain; TBP7_like subfamily, limited to fungi. TBP7, or TAT-binding protein homolog 7, is ...
 324-364 8.45e-04

Bromodomain; TBP7_like subfamily, limited to fungi. TBP7, or TAT-binding protein homolog 7, is a yeast protein of unknown function that contains AAA-superfamily ATP-ase domains and a bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99923  Cd Length: 119  Bit Score: 40.13  E-value: 8.45e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2477810793 324 HPMDLGTIERKLKNNEYKTAQAVVDDFNLMVQNAVTFNGPD 364
Cdd:cd05491    63 YNMDLDTIEERLWNGYYATPKDFLKDIKRIVRDAKTIGDRE 103
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 35-295 1.45e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.21  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793  35 STQNHVTEVSPINGTNKPEENDKTATLNCQGTEQLSLTNGAGSTVSPPKSPTEPADV-----------PAPSGTTATQke 103
Cdd:pfam05109 408 TATNATTTTHKVIFSKAPESTTTSPTLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTgptvstadvtsPTPAGTTSGA-- 485

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 104 eeKPLTSTPadgSDKEPKLENLIPDApvtqeTGSTVGTDQASPQDTKASQDVSKpPTDSSSDAKVENNVQDSGVKTELPH 183
Cdd:pfam05109 486 --SPVTPSP---SPRDNGTESKAPDM-----TSPTSAVTTPTPNATSPTPAVTT-PTPNATSPTLGKTSPTSAVTTPTPN 554

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 184 HPSTSTKLDTmpgdnPTSNApTVPSLQTSdqdmpdAPDAPMSPTKVSRERDADADDEPAPKRTKLEDEGSAEvklpdlpT 263
Cdd:pfam05109 555 ATSPTPAVTT-----PTPNA-TIPTLGKT------SPTSAVTTPTPNATSPTVGETSPQANTTNHTLGGTSS-------T 615

                         250       260       270
                  ....*....|....*....|....*....|..
gi 2477810793 264 PVTETPARttvNGEATMTKVQHKFVLKGIQSL 295
Cdd:pfam05109 616 PVVTSPPK---NATSAVTTGQHNITSSSTSSM 644
Bromodomain_1 cd05494
Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated ...
 288-353 2.50e-03

Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99926 [Multi-domain]  Cd Length: 114  Bit Score: 38.58  E-value: 2.50e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2477810793 288 VLKGIQSLKRMNDARFYREPVDPIKMNIPHYPQIIKHPMDLGTIErklkNNEYKTAQAVVDDFNLM 353
Cdd:cd05494     8 VLRELKRHRRNEDAWPFLEPVNPPRRGAPDYRDVIKRPMSFGTKV----NNIVETGARDLEDLQIV 69
Bromo_ZMYND11 cd05492
Bromodomain; ZMYND11_like sub-family. ZMYND11 or BS69 is a ubiquitously expressed nuclear ...
 505-552 3.13e-03

Bromodomain; ZMYND11_like sub-family. ZMYND11 or BS69 is a ubiquitously expressed nuclear protein that has been shown to associate with chromatin. It interacts with chromatin remodeling factors and might play a role in chromatin remodeling and gene expression. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99924  Cd Length: 109  Bit Score: 38.13  E-value: 3.13e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2477810793 505 DPVALNIPTYHSIIKKPMDLSTVQSKLKTGQYENAKEFEVDMRQIFKN 552
Cdd:cd05492    30 RGKATKLPKRRRLIHTHLDVADIQEKINSEKYTSLEEFKADALLLLHN 77
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
74-244 3.55e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 40.99  E-value: 3.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793  74 GAGSTVSPPKSPTEPADVPAPSGTTATQKEEEKPLTSTPADGSDKEPKLENLIPDAPVTQETGSTVGTDQASPQDTKASQ 153
Cdd:PRK07003  363 TGGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDA 442

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793 154 DVSKPPTDSSSDAKV--ENNVQDSGVKTELPHHPSTSTKLDTMPgdnPTSNAPTVPSLQTSDQDMPDAPDaPMSPTKVSR 231
Cdd:PRK07003  443 ADGDAPVPAKANARAsaDSRCDERDAQPPADSGSASAPASDAPP---DAAFEPAPRAAAPSAATPAAVPD-ARAPAAASR 518

                         170
                  ....*....|...
gi 2477810793 232 ERDADADDEPAPK 244
Cdd:PRK07003  519 EDAPAAAAPPAPE 531
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 2-273 5.41e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 5.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793    2 ATPPPEAPPVVKEDKPQLPPSPNG-ASSVDVGLTSTQNHVTEVSPINGTNKPEENDKTATLNCQGTEQLSLTNGAGSTVS 80
Cdd:PHA03307   125 SPPPSPAPDLSEMLRPVGSPGPPPaASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASP 204

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793   81 PPKSPTEPADVPAPSGTTATQKEEEKPLTSTPADGSDKEPK-----LENLIPDAPVTQETGSTVGTDQASPQDTKA-SQD 154
Cdd:PHA03307   205 RPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSgcgwgPENECPLPRPAPITLPTRIWEASGWNGPSSrPGP 284

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2477810793  155 VSKPPTDSSSDAKVENNVQDSGVKTELPHH-----PSTSTKLDTMPGDNPTSNAPTVPSLQTSDQDMPDAPDAPMSPTKV 229
Cdd:PHA03307   285 ASSSSSPRERSPSPSPSSPGSGPAPSSPRAsssssSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSS 364

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 2477810793  230 SRERDADADDEPAPKRTKLEDEGSAEVKLPDLPTPVTETPARTT 273
Cdd:PHA03307   365 PRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFP 408
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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