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Conserved domains on  [gi|2506603494|gb|KAJ9002770|]
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proteasome regulatory particle base subunit [Exophiala dermatitidis]

Protein Classification

26S proteasome non-ATPase regulatory subunit 1( domain architecture ID 1001948)

26S proteasome non-ATPase regulatory subunit 1 (PSMD1), also known as RPN2, is a non-ATPase subunit of the 19S regulatory complex of the 26S proteasome which plays a critical role in the recognition of ubiquitinated protein substrates by the proteasome and is involved in the ATP-dependent unfolding and translocation of these substrates into the proteasome core for degradation

Gene Ontology:  GO:0043161|GO:0005838

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
RPN2 super family cl34911
26S proteasome regulatory complex component [Posttranslational modification, protein turnover, ...
 4-1074 0e+00

26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG5116:

Pssm-ID: 227446 [Multi-domain]  Cd Length: 926  Bit Score: 843.07  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494    4 LVSAAGLVGFLSEPDPELQSFALKQLDSQVDLLWTEIADSVPQIEALYEDESFPERELAAIVASKVYYHLQEYNESMAFA 83
Cdd:COG5116      3 MTTARILPALLAELRDGRESEALDVINAHVDQLWPEISDDLRYIEALYDDDSFDPREMAALCLSKVYYVLGEYQQAIEYA 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494   84 LGAGKHFRLDQPGEYEDTIISKCVDTFIALSASRDptlaaattagtqpqldtafeQGGDGaasmsasltspvtpfsqsvl 163
Cdd:COG5116     83 LRAGDRFLVDDGSFYYETIVYKSIEMYVHMMDSAY--------------------IGGDK-------------------- 122

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  164 psksllsrqntsafDPtnsgiqvgqagspeaviqqrgLQKALNRVIETLFERCFQEKRYRQVVGIALEARNLDILRRVIK 243
Cdd:COG5116    123 --------------DI---------------------IDRILDFVLEVIGAKCVDDSEIGYLLGIAAEGLRLDIIEKYLS 167

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  244 rasederkengeaTKKGEELMEYILDICMSLVEERGLRNEILKLILELLNEIPSPDYFAIAKCVVYLDQHSMASNMLRHL 323
Cdd:COG5116    168 -------------DGNDCDIINYLLDLAITLVEEEGFRKEILRMLAEIGPGKPKPDYFYVIKAVVYLNDAEKAKALIEKL 234

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  324 VEKGDSRSLAvayQVSFDLYDNSTQEFLqkvreelsEMLPEEtkteaapqdadkmdedvqgkaedqlqqelqdsagapap 403
Cdd:COG5116    235 VKENDLLLYA---QVAFDLEDSASQEIL--------EILVTE-------------------------------------- 265

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  404 fknskLTKPEEQDAIKKIrdiLDGLTSTHLNIEFLHKSNRVDHTILNKVKDSLEPRYSIYHTAVTLSAGFMHAKTANDTF 483
Cdd:COG5116    266 -----LVAQGYDQAVMSI---LSGEFTKKYLGAFLLEKNNTDFKFLNSSKSSLARKFSRFHYAVSLANSFMNLGTSNDSF 337

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  484 FRQNLEWLGKAVNWSKFTATAVFGVIHQGNINQVQRLLSPYLPKAGGlgshDSPYSQGGSLFAYGLLCANHKSRAVDFLR 563
Cdd:COG5116    338 YRNNLDWLGKASNWAKFTATASLGVIHLGNSNPGYEILKPYLPSEVA----SSRQKEGGALYALGLIKAGFGREDTEYLL 413

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  564 EKFKEATEE---VVQHGGALGLGVAGMASGDEAVFEDLRNVLWSDSAINGEAVGLAMGLVMLGSGNTKVLSDMIQHAHDT 640
Cdd:COG5116    414 EYFLDTEDEltpELAYGVCLGIGLINMGSANREIYEKLKELLKNDRALLGEAAVYGMGLLMLGTWSVEAIEDMRTYAGET 493

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  641 QHEKIVRGLAVGMSLIMYGRQEGADELIQGLLNDTDPTMRYGGILTIAMAYVGTGSNKAVRKLLHVAVSDVSDDVRRIAV 720
Cdd:COG5116    494 QHERIKRGLGIGFALILYGRQEMADDYINELLYDKDSILRYNGVFSLALAYVGTGNLGVVSTLLHYAVSDGNDDVRRAAV 573

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  721 LSLGFILFRKYSSVPRMVELLAESYNPHVRYGAAMALGISCAGTGLDEAIDLLEPMLKDPTDFVRQGALIALSMVLIQQT 800
Cdd:COG5116    574 IALGFVCCDDRDLLVGTVELLSESHNFHVRAGVAVALGIACAGTGDKVATDILEALMYDTNDFVRQSAMIAVGMILMQCN 653

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  801 EAMNPKVGTIRKQMLKIISDRHEDAMCKFGCALAMGILDAGGRNCTINLQTQTGNLNMLGIVGIVVFTQYWYWFPLAHFF 880
Cdd:COG5116    654 PELNPNVKRIIKKFNRVIVDKHESGLAKLGAVLAQGISEAGGRNVTISLRNATGILSADRIVGLVLFLQYWYWFPLIHFV 733

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  881 SLSLTPTSVIGIDQKLEAPVFKFHCNTRPSLFDYPPEQQVKADEAPEKVKTAVLSTTAQAKRRAARKEKQQRRDSMDVDT 960
Cdd:COG5116    734 SLSFLPTTVIGIRGSQAIPKFCFNEDLEEEEFEYPRMYEEASGKSVRKVNTAVLSTTIKAAARAKQKPKEKGPNDKEIKI 813

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  961 VTPVTPKIEKGDKMETDEAAAKEDEGKKteegekkegetgevNKKKAEKEKVgyeiSNMSRVLPAQLKYLSF-PDQRYQP 1039
Cdd:COG5116    814 ESPSVETEGERCTIKQREEKGIDAPAIL--------------NVKKKKPYKV----DNMTRILPQQSRYISFiKDDRFVP 875

                         1050      1060      1070
                   ....*....|....*....|....*....|....*
gi 2506603494 1040 VKKPTGGVMVVLDTEPDKEREIIPlTVSKVEPVAA 1074
Cdd:COG5116    876 VRKFKGGVVVLRDREPKEPVALIE-TVRQMKDVNA 909
 
Name Accession Description Interval E-value
RPN2 COG5116
26S proteasome regulatory complex component [Posttranslational modification, protein turnover, ...
 4-1074 0e+00

26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227446 [Multi-domain]  Cd Length: 926  Bit Score: 843.07  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494    4 LVSAAGLVGFLSEPDPELQSFALKQLDSQVDLLWTEIADSVPQIEALYEDESFPERELAAIVASKVYYHLQEYNESMAFA 83
Cdd:COG5116      3 MTTARILPALLAELRDGRESEALDVINAHVDQLWPEISDDLRYIEALYDDDSFDPREMAALCLSKVYYVLGEYQQAIEYA 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494   84 LGAGKHFRLDQPGEYEDTIISKCVDTFIALSASRDptlaaattagtqpqldtafeQGGDGaasmsasltspvtpfsqsvl 163
Cdd:COG5116     83 LRAGDRFLVDDGSFYYETIVYKSIEMYVHMMDSAY--------------------IGGDK-------------------- 122

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  164 psksllsrqntsafDPtnsgiqvgqagspeaviqqrgLQKALNRVIETLFERCFQEKRYRQVVGIALEARNLDILRRVIK 243
Cdd:COG5116    123 --------------DI---------------------IDRILDFVLEVIGAKCVDDSEIGYLLGIAAEGLRLDIIEKYLS 167

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  244 rasederkengeaTKKGEELMEYILDICMSLVEERGLRNEILKLILELLNEIPSPDYFAIAKCVVYLDQHSMASNMLRHL 323
Cdd:COG5116    168 -------------DGNDCDIINYLLDLAITLVEEEGFRKEILRMLAEIGPGKPKPDYFYVIKAVVYLNDAEKAKALIEKL 234

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  324 VEKGDSRSLAvayQVSFDLYDNSTQEFLqkvreelsEMLPEEtkteaapqdadkmdedvqgkaedqlqqelqdsagapap 403
Cdd:COG5116    235 VKENDLLLYA---QVAFDLEDSASQEIL--------EILVTE-------------------------------------- 265

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  404 fknskLTKPEEQDAIKKIrdiLDGLTSTHLNIEFLHKSNRVDHTILNKVKDSLEPRYSIYHTAVTLSAGFMHAKTANDTF 483
Cdd:COG5116    266 -----LVAQGYDQAVMSI---LSGEFTKKYLGAFLLEKNNTDFKFLNSSKSSLARKFSRFHYAVSLANSFMNLGTSNDSF 337

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  484 FRQNLEWLGKAVNWSKFTATAVFGVIHQGNINQVQRLLSPYLPKAGGlgshDSPYSQGGSLFAYGLLCANHKSRAVDFLR 563
Cdd:COG5116    338 YRNNLDWLGKASNWAKFTATASLGVIHLGNSNPGYEILKPYLPSEVA----SSRQKEGGALYALGLIKAGFGREDTEYLL 413

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  564 EKFKEATEE---VVQHGGALGLGVAGMASGDEAVFEDLRNVLWSDSAINGEAVGLAMGLVMLGSGNTKVLSDMIQHAHDT 640
Cdd:COG5116    414 EYFLDTEDEltpELAYGVCLGIGLINMGSANREIYEKLKELLKNDRALLGEAAVYGMGLLMLGTWSVEAIEDMRTYAGET 493

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  641 QHEKIVRGLAVGMSLIMYGRQEGADELIQGLLNDTDPTMRYGGILTIAMAYVGTGSNKAVRKLLHVAVSDVSDDVRRIAV 720
Cdd:COG5116    494 QHERIKRGLGIGFALILYGRQEMADDYINELLYDKDSILRYNGVFSLALAYVGTGNLGVVSTLLHYAVSDGNDDVRRAAV 573

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  721 LSLGFILFRKYSSVPRMVELLAESYNPHVRYGAAMALGISCAGTGLDEAIDLLEPMLKDPTDFVRQGALIALSMVLIQQT 800
Cdd:COG5116    574 IALGFVCCDDRDLLVGTVELLSESHNFHVRAGVAVALGIACAGTGDKVATDILEALMYDTNDFVRQSAMIAVGMILMQCN 653

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  801 EAMNPKVGTIRKQMLKIISDRHEDAMCKFGCALAMGILDAGGRNCTINLQTQTGNLNMLGIVGIVVFTQYWYWFPLAHFF 880
Cdd:COG5116    654 PELNPNVKRIIKKFNRVIVDKHESGLAKLGAVLAQGISEAGGRNVTISLRNATGILSADRIVGLVLFLQYWYWFPLIHFV 733

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  881 SLSLTPTSVIGIDQKLEAPVFKFHCNTRPSLFDYPPEQQVKADEAPEKVKTAVLSTTAQAKRRAARKEKQQRRDSMDVDT 960
Cdd:COG5116    734 SLSFLPTTVIGIRGSQAIPKFCFNEDLEEEEFEYPRMYEEASGKSVRKVNTAVLSTTIKAAARAKQKPKEKGPNDKEIKI 813

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  961 VTPVTPKIEKGDKMETDEAAAKEDEGKKteegekkegetgevNKKKAEKEKVgyeiSNMSRVLPAQLKYLSF-PDQRYQP 1039
Cdd:COG5116    814 ESPSVETEGERCTIKQREEKGIDAPAIL--------------NVKKKKPYKV----DNMTRILPQQSRYISFiKDDRFVP 875

                         1050      1060      1070
                   ....*....|....*....|....*....|....*
gi 2506603494 1040 VKKPTGGVMVVLDTEPDKEREIIPlTVSKVEPVAA 1074
Cdd:COG5116    876 VRKFKGGVVVLRDREPKEPVALIE-TVRQMKDVNA 909
RPN2_C pfam18004
26S proteasome regulatory subunit RPN2 C-terminal domain; This is the C-terminal domain found ...
 887-1062 1.17e-72

26S proteasome regulatory subunit RPN2 C-terminal domain; This is the C-terminal domain found in S. cerevisiae Rpn2 (26S proteasome regulatory subunit RPN2) as well as other eukaryotic species. A study revealed that the C-terminal 52 residues of the Rpn2 C-terminal domain are responsible for mediating interactions with the ubiquitin-binding subunit Rpn13. Futhermore, the extreme C-terminal 20 or 21 residues of Rpn2 (926-945 or 925-945) of S. cerevisiae, were shown to be equally effective at binding Rpn13. Multiple sequence alignments indicate that Rpn2 orthologs are highly conserved in this C-terminal region and share characteriztic acidic, aromatic, and proline residues, suggesting a common function. In the structure of Rpn2 from S. cerevisiae, this region is exposed and disordered, and is thus accessible for associating with Rpn13. The Rpn2 binding surface of human Rpn13 has been mapped by nuclear magnetic resonance titration to one surface of its Pru domain.


Pssm-ID: 465613 [Multi-domain]  Cd Length: 159  Bit Score: 238.24  E-value: 1.17e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  887 TSVIGIDQKLEAPVFKFHCNTRPSLFDYPPEQQVKADEAPEKVKTAVLSTTAQAKRRAARKEKQQrrdsmdvdtvtpvtP 966
Cdd:pfam18004    1 TAIIGLNKDLKMPKFEFNSNAKPSLFAYPPETEEKKEKAPEKVATAVLSTTAKAKARAKKKEKEK--------------E 66

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  967 KIEKGDKMETDEAAAKEDEGKKTEEGEKKEGEtgevnKKKAEKEKVGYEISNMSRVLPAQLKYLSF-PDQRYQPVKK-PT 1044
Cdd:pfam18004   67 KEKEEDKMDVDEEKEEKEKKEKEKEEKEKKAE-----KKKKEKEPTFYKLENPSRVLPAQLKYISFiKDSRYVPVKKkGT 141

                          170
                   ....*....|....*...
gi 2506603494 1045 GGVMVVLDTEPDKEREII 1062
Cdd:pfam18004  142 GGIIVLKDTKPDEPEELI 159
 
Name Accession Description Interval E-value
RPN2 COG5116
26S proteasome regulatory complex component [Posttranslational modification, protein turnover, ...
 4-1074 0e+00

26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227446 [Multi-domain]  Cd Length: 926  Bit Score: 843.07  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494    4 LVSAAGLVGFLSEPDPELQSFALKQLDSQVDLLWTEIADSVPQIEALYEDESFPERELAAIVASKVYYHLQEYNESMAFA 83
Cdd:COG5116      3 MTTARILPALLAELRDGRESEALDVINAHVDQLWPEISDDLRYIEALYDDDSFDPREMAALCLSKVYYVLGEYQQAIEYA 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494   84 LGAGKHFRLDQPGEYEDTIISKCVDTFIALSASRDptlaaattagtqpqldtafeQGGDGaasmsasltspvtpfsqsvl 163
Cdd:COG5116     83 LRAGDRFLVDDGSFYYETIVYKSIEMYVHMMDSAY--------------------IGGDK-------------------- 122

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  164 psksllsrqntsafDPtnsgiqvgqagspeaviqqrgLQKALNRVIETLFERCFQEKRYRQVVGIALEARNLDILRRVIK 243
Cdd:COG5116    123 --------------DI---------------------IDRILDFVLEVIGAKCVDDSEIGYLLGIAAEGLRLDIIEKYLS 167

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  244 rasederkengeaTKKGEELMEYILDICMSLVEERGLRNEILKLILELLNEIPSPDYFAIAKCVVYLDQHSMASNMLRHL 323
Cdd:COG5116    168 -------------DGNDCDIINYLLDLAITLVEEEGFRKEILRMLAEIGPGKPKPDYFYVIKAVVYLNDAEKAKALIEKL 234

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  324 VEKGDSRSLAvayQVSFDLYDNSTQEFLqkvreelsEMLPEEtkteaapqdadkmdedvqgkaedqlqqelqdsagapap 403
Cdd:COG5116    235 VKENDLLLYA---QVAFDLEDSASQEIL--------EILVTE-------------------------------------- 265

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  404 fknskLTKPEEQDAIKKIrdiLDGLTSTHLNIEFLHKSNRVDHTILNKVKDSLEPRYSIYHTAVTLSAGFMHAKTANDTF 483
Cdd:COG5116    266 -----LVAQGYDQAVMSI---LSGEFTKKYLGAFLLEKNNTDFKFLNSSKSSLARKFSRFHYAVSLANSFMNLGTSNDSF 337

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  484 FRQNLEWLGKAVNWSKFTATAVFGVIHQGNINQVQRLLSPYLPKAGGlgshDSPYSQGGSLFAYGLLCANHKSRAVDFLR 563
Cdd:COG5116    338 YRNNLDWLGKASNWAKFTATASLGVIHLGNSNPGYEILKPYLPSEVA----SSRQKEGGALYALGLIKAGFGREDTEYLL 413

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  564 EKFKEATEE---VVQHGGALGLGVAGMASGDEAVFEDLRNVLWSDSAINGEAVGLAMGLVMLGSGNTKVLSDMIQHAHDT 640
Cdd:COG5116    414 EYFLDTEDEltpELAYGVCLGIGLINMGSANREIYEKLKELLKNDRALLGEAAVYGMGLLMLGTWSVEAIEDMRTYAGET 493

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  641 QHEKIVRGLAVGMSLIMYGRQEGADELIQGLLNDTDPTMRYGGILTIAMAYVGTGSNKAVRKLLHVAVSDVSDDVRRIAV 720
Cdd:COG5116    494 QHERIKRGLGIGFALILYGRQEMADDYINELLYDKDSILRYNGVFSLALAYVGTGNLGVVSTLLHYAVSDGNDDVRRAAV 573

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  721 LSLGFILFRKYSSVPRMVELLAESYNPHVRYGAAMALGISCAGTGLDEAIDLLEPMLKDPTDFVRQGALIALSMVLIQQT 800
Cdd:COG5116    574 IALGFVCCDDRDLLVGTVELLSESHNFHVRAGVAVALGIACAGTGDKVATDILEALMYDTNDFVRQSAMIAVGMILMQCN 653

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  801 EAMNPKVGTIRKQMLKIISDRHEDAMCKFGCALAMGILDAGGRNCTINLQTQTGNLNMLGIVGIVVFTQYWYWFPLAHFF 880
Cdd:COG5116    654 PELNPNVKRIIKKFNRVIVDKHESGLAKLGAVLAQGISEAGGRNVTISLRNATGILSADRIVGLVLFLQYWYWFPLIHFV 733

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  881 SLSLTPTSVIGIDQKLEAPVFKFHCNTRPSLFDYPPEQQVKADEAPEKVKTAVLSTTAQAKRRAARKEKQQRRDSMDVDT 960
Cdd:COG5116    734 SLSFLPTTVIGIRGSQAIPKFCFNEDLEEEEFEYPRMYEEASGKSVRKVNTAVLSTTIKAAARAKQKPKEKGPNDKEIKI 813

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  961 VTPVTPKIEKGDKMETDEAAAKEDEGKKteegekkegetgevNKKKAEKEKVgyeiSNMSRVLPAQLKYLSF-PDQRYQP 1039
Cdd:COG5116    814 ESPSVETEGERCTIKQREEKGIDAPAIL--------------NVKKKKPYKV----DNMTRILPQQSRYISFiKDDRFVP 875

                         1050      1060      1070
                   ....*....|....*....|....*....|....*
gi 2506603494 1040 VKKPTGGVMVVLDTEPDKEREIIPlTVSKVEPVAA 1074
Cdd:COG5116    876 VRKFKGGVVVLRDREPKEPVALIE-TVRQMKDVNA 909
RPN2_C pfam18004
26S proteasome regulatory subunit RPN2 C-terminal domain; This is the C-terminal domain found ...
 887-1062 1.17e-72

26S proteasome regulatory subunit RPN2 C-terminal domain; This is the C-terminal domain found in S. cerevisiae Rpn2 (26S proteasome regulatory subunit RPN2) as well as other eukaryotic species. A study revealed that the C-terminal 52 residues of the Rpn2 C-terminal domain are responsible for mediating interactions with the ubiquitin-binding subunit Rpn13. Futhermore, the extreme C-terminal 20 or 21 residues of Rpn2 (926-945 or 925-945) of S. cerevisiae, were shown to be equally effective at binding Rpn13. Multiple sequence alignments indicate that Rpn2 orthologs are highly conserved in this C-terminal region and share characteriztic acidic, aromatic, and proline residues, suggesting a common function. In the structure of Rpn2 from S. cerevisiae, this region is exposed and disordered, and is thus accessible for associating with Rpn13. The Rpn2 binding surface of human Rpn13 has been mapped by nuclear magnetic resonance titration to one surface of its Pru domain.


Pssm-ID: 465613 [Multi-domain]  Cd Length: 159  Bit Score: 238.24  E-value: 1.17e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  887 TSVIGIDQKLEAPVFKFHCNTRPSLFDYPPEQQVKADEAPEKVKTAVLSTTAQAKRRAARKEKQQrrdsmdvdtvtpvtP 966
Cdd:pfam18004    1 TAIIGLNKDLKMPKFEFNSNAKPSLFAYPPETEEKKEKAPEKVATAVLSTTAKAKARAKKKEKEK--------------E 66

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  967 KIEKGDKMETDEAAAKEDEGKKTEEGEKKEGEtgevnKKKAEKEKVGYEISNMSRVLPAQLKYLSF-PDQRYQPVKK-PT 1044
Cdd:pfam18004   67 KEKEEDKMDVDEEKEEKEKKEKEKEEKEKKAE-----KKKKEKEPTFYKLENPSRVLPAQLKYISFiKDSRYVPVKKkGT 141

                          170
                   ....*....|....*...
gi 2506603494 1045 GGVMVVLDTEPDKEREII 1062
Cdd:pfam18004  142 GGIIVLKDTKPDEPEELI 159
RPN1 COG5110
26S proteasome regulatory complex component [Posttranslational modification, protein turnover, ...
 373-897 8.31e-19

26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227441 [Multi-domain]  Cd Length: 881  Bit Score: 92.30  E-value: 8.31e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  373 QDADKMDEDVQGkAEDQL--QQELQDSAGAPAPFKNSKltkPEEQDAIK--KIRDILDGLtSTHLNIEFLHKSNRVDHTI 448
Cdd:COG5110    268 QKSKEIIEYVRA-IEDPDykKQCLYILARQNLYYEASD---EEEKDILSngYLSDHFRYL-GKELNLDKPKVPEDILKGH 342

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  449 LNKVKDSLEPRySIY----HTAVTLSAGFMHAKTANDTFFRQNLEWLGKAVNWSKFTATAVFGVIHQGNINQVQRLLSPY 524
Cdd:COG5110    343 LKYDKDTRQLA-GIGsanqNLAMGFVNDPINLGYENDSLIPLDDEWIYKCKVPGLISAFASIGVIESWNSDKGLETLDKY 421

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  525 LpkagglgSHDSPYSQGGSLFAYGLL-CANHKSR--AVDFLREKFKEATeevVQHGGALGLGVAGMASGDEAvfEDLRNV 601
Cdd:COG5110    422 L-------YADESYRKAGALLGIGLSgLRVFEERppALALLSNYLQSSS---SKHVIAAILGLGAAFSGTQA--EEVLEL 489

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  602 LW-----SDSAINGEAV-GLAMGLVMLGSGNTKVLSDMIQ----HAHDTQHEKIVRGLAVGMSLIMYGRQEGADELIQGL 671
Cdd:COG5110    490 LQpimfsTDSPIEVVFFaSLTLGSVFVGTCNGDLTSLILQtfveRGKIESETQWFRFLALGLASLFYGRKDQVDDVEETI 569

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  672 LNDTDPTMRYGGILTIAMAYVGTGSNKAVRKLLHVAVSDVSDDVRR-------IAVLSLGFILFRKYSS---VPRMVELL 741
Cdd:COG5110    570 MAIEGALSKHEEILVKGCQYVGTGDVLVIQSLLHVKDEFTGDTLKNeealiesLALLGCALIAMGEDIGsemVLRHFSHS 649

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  742 AESYNPHVRYGAAMALGISCAGTGLDEAIDLLEPMLKDPTDFVRQGALIALSMVliqQTEAMNPKVGTIRKQMLkiiSDR 821
Cdd:COG5110    650 MHYGSSHIRSVLPLAYGILSPSNPQMNVFDTLERSSHDGDLNVIINTIFAMGLI---GAGTLNARLAQLLRQLA---SYY 723

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  822 HEDAMCKFGCALAMGILDAGGRNCTINL----QTQTGNLNMLGIVGIVVF----------TQYWYWFplahFFSLSLTPT 887
Cdd:COG5110    724 YKESKALFVLRIAQGLLSLGKGTMTISPlyfdKTTLMPKNTAGLFTTVFMlldssifplvSSHALMY----FLLCQIRPQ 799

                          570
                   ....*....|
gi 2506603494  888 SVIGIDQKLE 897
Cdd:COG5110    800 KYVTLSEKGE 809
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 700-793 1.14e-13

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 67.36  E-value: 1.14e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  700 VRKLLHVAVSDVSDDVRRIAVLSLGfiLFRKYSSVPRMVELLaESYNPHVRYGAAMALGIscagTGLDEAIDLLEPMLKD 779
Cdd:pfam13646    1 LPALLQALLRDPDPEVRAAAIRALG--RIGDPEAVPALLELL-KDEDPAVRRAAAEALGK----IGDPEALPALLELLRD 73

                           90
                   ....*....|....*
gi 2506603494  780 PTD-FVRQGALIALS 793
Cdd:pfam13646   74 DDDdVVRAAAAEALA 88
HEAT COG1413
HEAT repeat [General function prediction only];
646-792 1.25e-12

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 66.19  E-value: 1.25e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  646 VRGLAVgMSLIMYGRQEGADELIQgLLNDTDPTMRYggilTIAMAYVGTGSNKAVRKLLHvAVSDVSDDVRRIAVLSLGF 725
Cdd:COG1413      1 VRRAAA-RALGRLGDPAAVPALIA-ALADEDPDVRA----AAARALGRLGDPRAVPALLE-ALKDPDPEVRAAAAEALGR 73

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2506603494  726 IlfRKYSSVPRMVELLAESyNPHVRYGAAMALGiscaGTGLDEAIDLLEPMLKDPTDFVRQGALIAL 792
Cdd:COG1413     74 I--GDPEAVPALIAALKDE-DPEVRRAAAEALG----RLGDPAAVPALLEALKDPDWEVRRAAARAL 133
HEAT COG1413
HEAT repeat [General function prediction only];
625-758 8.72e-09

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 55.02  E-value: 8.72e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  625 GNTKVLSDMIQHAHDTQHEkiVRGLAVgMSLIMYGRQEGADELIQgLLNDTDPTMRYGGILTIAMayvgTGSNKAVRKLL 704
Cdd:COG1413     13 GDPAAVPALIAALADEDPD--VRAAAA-RALGRLGDPRAVPALLE-ALKDPDPEVRAAAAEALGR----IGDPEAVPALI 84

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2506603494  705 HvAVSDVSDDVRRIAVLSLGFIlfRKYSSVPRMVELLAESyNPHVRYGAAMALG 758
Cdd:COG1413     85 A-ALKDEDPEVRRAAAEALGRL--GDPAAVPALLEALKDP-DWEVRRAAARALG 134
PC_rep pfam01851
Proteasome/cyclosome repeat;
752-786 2.76e-08

Proteasome/cyclosome repeat;


Pssm-ID: 460361 [Multi-domain]  Cd Length: 35  Bit Score: 50.50  E-value: 2.76e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2506603494  752 GAAMALGISCAGTGLDEAIDLLEPMLKDPTDFVRQ 786
Cdd:pfam01851    1 GAALALGLIHAGSGNEEALDLLLPYLSDTSAESRA 35
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 664-758 1.69e-07

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 50.03  E-value: 1.69e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  664 ADELIQGLLNDTDPTMRYGGILTIAMAyvgtgSNKAVRKLLHVAVSDVSDDVRRIAVLSLGFIlfRKYSSVPRMVELLAE 743
Cdd:pfam13646    1 LPALLQALLRDPDPEVRAAAIRALGRI-----GDPEAVPALLELLKDEDPAVRRAAAEALGKI--GDPEALPALLELLRD 73

                           90
                   ....*....|....*
gi 2506603494  744 SYNPHVRYGAAMALG 758
Cdd:pfam13646   74 DDDDVVRAAAAEALA 88
HEAT COG1413
HEAT repeat [General function prediction only];
715-793 3.09e-07

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 50.78  E-value: 3.09e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2506603494  715 VRRIAVLSLGFIlfRKYSSVPRMVELLAESyNPHVRYGAAMALGiscaGTGLDEAIDLLEPMLKDPTDFVRQGALIALS 793
Cdd:COG1413      1 VRRAAARALGRL--GDPAAVPALIAALADE-DPDVRAAAARALG----RLGDPRAVPALLEALKDPDPEVRAAAAEALG 72
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 747-793 1.41e-06

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 46.21  E-value: 1.41e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2506603494  747 PHVRYGAAMALGISCAGTG------LDEAIDLLEPMLKDPTDFVRQGALIALS 793
Cdd:pfam13513    1 WRVREAAALALGSLAEGGPdllapaVPELLPALLPLLNDDSDLVREAAAWALG 53
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 734-795 2.65e-06

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 46.56  E-value: 2.65e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2506603494  734 VPRMVELLAESYNPHVRYGAAMALGiscaGTGLDEAIDLLEPMLKDPTDFVRQGALIALSMV 795
Cdd:pfam13646    1 LPALLQALLRDPDPEVRAAAIRALG----RIGDPEAVPALLELLKDEDPAVRRAAAEALGKI 58
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 630-724 1.30e-05

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 44.64  E-value: 1.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506603494  630 LSDMIQHAHDTQHEKiVRGLAVgMSLIMYGRQEGADELIQgLLNDTDPTMRYGGILTIAMayvgTGSNKAVRKLLHVAVS 709
Cdd:pfam13646    1 LPALLQALLRDPDPE-VRAAAI-RALGRIGDPEAVPALLE-LLKDEDPAVRRAAAEALGK----IGDPEALPALLELLRD 73

                           90
                   ....*....|....*
gi 2506603494  710 DVSDDVRRIAVLSLG 724
Cdd:pfam13646   74 DDDDVVRAAAAEALA 88
PC_rep pfam01851
Proteasome/cyclosome repeat;
615-646 6.70e-05

Proteasome/cyclosome repeat;


Pssm-ID: 460361 [Multi-domain]  Cd Length: 35  Bit Score: 40.87  E-value: 6.70e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2506603494  615 LAMGLVMLGSGNTKVLSDMIQHAHDTQHEKIV 646
Cdd:pfam01851    4 LALGLIHAGSGNEEALDLLLPYLSDTSAESRA 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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