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Conserved domains on  [gi|2545657646|gb|KAK0540969|]
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hypothetical protein OC835_000396 [Tilletia horrida]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
402-526 3.62e-08

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.84  E-value: 3.62e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545657646  402 SPDRRTLVAVGDSNDVFLRRISpSGELqnISTLRdlsflmaGSGGASYSTSWHPSGLQFAAGSSDGRVHVWDIRSSKPLA 481
Cdd:COG2319    255 SPDGRLLASGSADGTVRLWDLA-TGEL--LRTLT-------GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 324

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2545657646  482 CLETAEGSA-GIAAAAHNGMLFSDEED--------------------TSAVRTVKFSPCGRMLAYA 526
Cdd:COG2319    325 TLTGHTGAVrSVAFSPDGKTLASGSDDgtvrlwdlatgellrtltghTGAVTSVAFSPDGRTLASG 390
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
402-526 3.62e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.84  E-value: 3.62e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545657646  402 SPDRRTLVAVGDSNDVFLRRISpSGELqnISTLRdlsflmaGSGGASYSTSWHPSGLQFAAGSSDGRVHVWDIRSSKPLA 481
Cdd:COG2319    255 SPDGRLLASGSADGTVRLWDLA-TGEL--LRTLT-------GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 324

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2545657646  482 CLETAEGSA-GIAAAAHNGMLFSDEED--------------------TSAVRTVKFSPCGRMLAYA 526
Cdd:COG2319    325 TLTGHTGAVrSVAFSPDGKTLASGSDDgtvrlwdlatgellrtltghTGAVTSVAFSPDGRTLASG 390
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 357-524 3.99e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.72  E-value: 3.99e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545657646  357 STNEKMVRSYRVRTPRvsalpferypglvPIRTAYFST-AINHTSTSPDRRTLVAVGDSNDVFLRRISpsgELQNISTLR 435
Cdd:cd00200    153 SSQDGTIKLWDLRTGK-------------CVATLTGHTgEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---TGKCLGTLR 216

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545657646  436 dlsflmaGSGGASYSTSWHPSGLQFAAGSSDGRVHVWDIRSSKPLACLEtaegsagiaaaAHngmlfsdeedTSAVRTVK 515
Cdd:cd00200    217 -------GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLS-----------GH----------TNSVTSLA 268


                   ....*....
gi 2545657646  516 FSPCGRMLA 524
Cdd:cd00200    269 WSPDGKRLA 277
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 449-473 6.57e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 6.57e-04
                            10        20
                    ....*....|....*....|....*
gi 2545657646   449 YSTSWHPSGLQFAAGSSDGRVHVWD 473
Cdd:smart00320   16 TSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
402-526 3.62e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.84  E-value: 3.62e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545657646  402 SPDRRTLVAVGDSNDVFLRRISpSGELqnISTLRdlsflmaGSGGASYSTSWHPSGLQFAAGSSDGRVHVWDIRSSKPLA 481
Cdd:COG2319    255 SPDGRLLASGSADGTVRLWDLA-TGEL--LRTLT-------GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 324

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2545657646  482 CLETAEGSA-GIAAAAHNGMLFSDEED--------------------TSAVRTVKFSPCGRMLAYA 526
Cdd:COG2319    325 TLTGHTGAVrSVAFSPDGKTLASGSDDgtvrlwdlatgellrtltghTGAVTSVAFSPDGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
393-524 5.86e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.07  E-value: 5.86e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545657646  393 STAINHTSTSPDRRTLVAVGDSNDVFLRRISpSGELqnISTLRdlsflmaGSGGASYSTSWHPSGLQFAAGSSDGRVHVW 472
Cdd:COG2319    162 SGAVTSVAFSPDGKLLASGSDDGTVRLWDLA-TGKL--LRTLT-------GHTGAVRSVAFSPDGKLLASGSADGTVRLW 231

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2545657646  473 DIRSSKPLACLETaegsagiaaaahngmlfsdeeDTSAVRTVKFSPCGRMLA 524
Cdd:COG2319    232 DLATGKLLRTLTG---------------------HSGSVRSVAFSPDGRLLA 262
WD40 COG2319
WD40 repeat [General function prediction only];
402-526 8.60e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.69  E-value: 8.60e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545657646  402 SPDRRTLVAVGDSNDVFLRRISpSGELqnISTLRdlsflmaGSGGASYSTSWHPSGLQFAAGSSDGRVHVWDIRSSKPLA 481
Cdd:COG2319    129 SPDGKTLASGSADGTVRLWDLA-TGKL--LRTLT-------GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 198

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 2545657646  482 CLEtaegsagiaaaAHngmlfsdeedTSAVRTVKFSPCGRMLAYA 526
Cdd:COG2319    199 TLT-----------GH----------TGAVRSVAFSPDGKLLASG 222
WD40 COG2319
WD40 repeat [General function prediction only];
393-526 9.47e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.69  E-value: 9.47e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545657646  393 STAINHTSTSPDRRTLVAVGDSNDVFLRRISpSGELqnISTLRdlsflmaGSGGASYSTSWHPSGLQFAAGSSDGRVHVW 472
Cdd:COG2319    204 TGAVRSVAFSPDGKLLASGSADGTVRLWDLA-TGKL--LRTLT-------GHSGSVRSVAFSPDGRLLASGSADGTVRLW 273

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2545657646  473 DIRSSKPLACLETAEGSAG----------IAAAAHNGM-----------LFSDEEDTSAVRTVKFSPCGRMLAYA 526
Cdd:COG2319    274 DLATGELLRTLTGHSGGVNsvafspdgklLASGSDDGTvrlwdlatgklLRTLTGHTGAVRSVAFSPDGKTLASG 348
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 357-524 3.99e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.72  E-value: 3.99e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545657646  357 STNEKMVRSYRVRTPRvsalpferypglvPIRTAYFST-AINHTSTSPDRRTLVAVGDSNDVFLRRISpsgELQNISTLR 435
Cdd:cd00200    153 SSQDGTIKLWDLRTGK-------------CVATLTGHTgEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---TGKCLGTLR 216

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545657646  436 dlsflmaGSGGASYSTSWHPSGLQFAAGSSDGRVHVWDIRSSKPLACLEtaegsagiaaaAHngmlfsdeedTSAVRTVK 515
Cdd:cd00200    217 -------GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLS-----------GH----------TNSVTSLA 268


                   ....*....
gi 2545657646  516 FSPCGRMLA 524
Cdd:cd00200    269 WSPDGKRLA 277
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 395-524 1.27e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.10  E-value: 1.27e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545657646  395 AINHTSTSPDRRTLVAVGDSNDVFLRRISPSGELQNIStlrdlsflmaGSGGASYSTSWHPSGLQFAAGSSDGRVHVWDI 474
Cdd:cd00200    137 WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLT----------GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL 206

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 2545657646  475 RSSKPLACLEtaegsagiaaaAHNGmlfsdeedtsAVRTVKFSPCGRMLA 524
Cdd:cd00200    207 STGKCLGTLR-----------GHEN----------GVNSVAFSPDGYLLA 235
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 395-526 1.90e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.71  E-value: 1.90e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545657646  395 AINHTSTSPDRRTLVAVGDSNDVFLRRISpSGELqnISTLRdlsflmaGSGGASYSTSWHPSGLQFAAGSSDGRVHVWDI 474
Cdd:cd00200     53 PVRDVAASADGTYLASGSSDKTIRLWDLE-TGEC--VRTLT-------GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV 122

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2545657646  475 RSSKPLACLEtaegsagiaaaAHngmlfsdeedTSAVRTVKFSPCGRMLAYA 526
Cdd:cd00200    123 ETGKCLTTLR-----------GH----------TDWVNSVAFSPDGTFVASS 153
WD40 COG2319
WD40 repeat [General function prediction only];
402-476 8.59e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.06  E-value: 8.59e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2545657646  402 SPDRRTLVAVGDSNDVFLRRISPSGELQNIStlrdlsflmaGSGGASYSTSWHPSGLQFAAGSSDGRVHVWDIRS 476
Cdd:COG2319    339 SPDGKTLASGSDDGTVRLWDLATGELLRTLT----------GHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 449-473 6.57e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 6.57e-04
                            10        20
                    ....*....|....*....|....*
gi 2545657646   449 YSTSWHPSGLQFAAGSSDGRVHVWD 473
Cdd:smart00320   16 TSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 443-524 1.05e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.32  E-value: 1.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545657646  443 GSGGASYSTSWHPSGLQFAAGSSDGRVHVWDIRSSKPLACLETAEGS-AGIAAAAHNGMLFSDEED-------------- 507
Cdd:cd00200      7 GHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPvRDVAASADGTYLASGSSDktirlwdletgecv 86

                           90       100
                   ....*....|....*....|...
gi 2545657646  508 ------TSAVRTVKFSPCGRMLA 524
Cdd:cd00200     87 rtltghTSYVSSVAFSPDGRILS 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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