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Conserved domains on  [gi|622703327|gb|KBC81881|]
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transposase, partial [Mycobacterium tuberculosis M2140]

Protein Classification

transposase( domain architecture ID 706256)

transposase binds to the end of a transposon and catalyze the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism

Gene Ontology:  GO:0032196|GO:0004803

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Transposase_mut super family cl27632
Transposase, Mutator family;
1-196 3.47e-88

Transposase, Mutator family;


The actual alignment was detected with superfamily member pfam00872:

Pssm-ID: 474953  Cd Length: 380  Bit Score: 263.86  E-value: 3.47e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 622703327    1 MTSSH-LIDTEQLLADQLAQASPDLLRGLLSTFIAALMGAEADALCGAGYRERSDERSNQRNGYRHRDFDTRAATIDVAI 79
Cdd:pfam00872   1 MTETHlLLDSEALQAIIELQGKDDLLRTLLKTVMNALLEAELTEHLGAARYERTEERSNQRNGSYSRTFITRAGTLELRI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 622703327   80 PKLRQGSYFPdWLLQRRKRAERALTSVVATCYLLGVSTRRMERLVETLGVTK-LSKSQVSIMAKELDEAVEAFRTRPLDA 158
Cdd:pfam00872  81 PRDRNGSFSP-ALLERYQRRERALDAVVIEMYVSGVSTRKVSDIVEELYGHKsVSKSTVSRITKRLDEAVGAFRNRPLEE 159
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 622703327  159 GPYTFLAADALVLKVREAGRVVGVHTLIATGVNAEGYR 196
Cdd:pfam00872 160 NEYPYLFLDATYLKVREEGRVVSKAVYIAIGIDADGRR 197
 
Name Accession Description Interval E-value
Transposase_mut pfam00872
Transposase, Mutator family;
1-196 3.47e-88

Transposase, Mutator family;


Pssm-ID: 307151  Cd Length: 380  Bit Score: 263.86  E-value: 3.47e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 622703327    1 MTSSH-LIDTEQLLADQLAQASPDLLRGLLSTFIAALMGAEADALCGAGYRERSDERSNQRNGYRHRDFDTRAATIDVAI 79
Cdd:pfam00872   1 MTETHlLLDSEALQAIIELQGKDDLLRTLLKTVMNALLEAELTEHLGAARYERTEERSNQRNGSYSRTFITRAGTLELRI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 622703327   80 PKLRQGSYFPdWLLQRRKRAERALTSVVATCYLLGVSTRRMERLVETLGVTK-LSKSQVSIMAKELDEAVEAFRTRPLDA 158
Cdd:pfam00872  81 PRDRNGSFSP-ALLERYQRRERALDAVVIEMYVSGVSTRKVSDIVEELYGHKsVSKSTVSRITKRLDEAVGAFRNRPLEE 159
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 622703327  159 GPYTFLAADALVLKVREAGRVVGVHTLIATGVNAEGYR 196
Cdd:pfam00872 160 NEYPYLFLDATYLKVREEGRVVSKAVYIAIGIDADGRR 197
transpos_IS256 NF033543
IS256 family transposase; Members of this family belong to the branch of the IS256-like family ...
1-196 4.33e-67

IS256 family transposase; Members of this family belong to the branch of the IS256-like family of transposases that includes the founding member. It excludes the IS1249 group.


Pssm-ID: 468074 [Multi-domain]  Cd Length: 406  Bit Score: 210.54  E-value: 4.33e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 622703327   1 MTSSHLIDTEQLLADQLAQASP-DLLRGLLSTFIAALMGAEADALCGAGYRERSDeRSNQRNGYRHRDFDTRAATIDVAI 79
Cdd:NF033543   4 TAVDELLDEALLGLKALEDLTDdELLRELLKALLEQLLEAELTAHLGAEKYERTG-RGNVRNGYYPRTVLTRGGPVELRV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 622703327  80 PKLRQGSYFPDWLLQRRKRAERALTSVVATCYLLGVSTRRMERLVETLGVTKLSKSQVSIMAKELDEAVEAFRTRPLDaG 159
Cdd:NF033543  83 PRDRDGSFEPQLILKRYRRSEKALEAVIIELYLKGVSTRDIQEALEELYGIDVSSKSVSRLTDAVDEEVEAWQNRPLE-E 161
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 622703327 160 PYTFLAADALVLKVREAGRVVGVHTLIATGVNAEGYR 196
Cdd:NF033543 162 RYPYVFLDATYLKVRDGGRVVNKAVLVALGVDADGKK 198
IS285 COG3328
Transposase (or an inactivated derivative) [Mobilome: prophages, transposons];
10-196 1.00e-66

Transposase (or an inactivated derivative) [Mobilome: prophages, transposons];


Pssm-ID: 442557  Cd Length: 400  Bit Score: 209.67  E-value: 1.00e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 622703327  10 EQLLADQLAQAS--PDLLRGLLSTFIAALMGAEADALCGAGYRERSD-ERSNQRNGYRHRDFDTRAATIDVAIPKLRQGS 86
Cdd:COG3328    9 EELLSELLEGDDlfDDLLRELLKELLEQALEAELDAHLGAEKYERTGgERGNSRNGYRERTVKTRVGELELRVPRDRDGS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 622703327  87 YFPdWLLQRRKRAERALTSVVATCYLLGVSTRRMERLVETLGVTKLSKSQVSIMAKELDEAVEAFRTRPLDaGPYTFLAA 166
Cdd:COG3328   89 FEP-QLLPKYQRREQALEEVIIELYAKGVSTRDIEEALEELYGTGLSKSTVSRITDKLDEEVEAWQNRPLE-ERYPYVYL 166
                        170       180       190
                 ....*....|....*....|....*....|
gi 622703327 167 DALVLKVREAGRVVGVHTLIATGVNAEGYR 196
Cdd:COG3328  167 DAIYLKVREDGRVVNKAVYVALGVNEDGRK 196
 
Name Accession Description Interval E-value
Transposase_mut pfam00872
Transposase, Mutator family;
1-196 3.47e-88

Transposase, Mutator family;


Pssm-ID: 307151  Cd Length: 380  Bit Score: 263.86  E-value: 3.47e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 622703327    1 MTSSH-LIDTEQLLADQLAQASPDLLRGLLSTFIAALMGAEADALCGAGYRERSDERSNQRNGYRHRDFDTRAATIDVAI 79
Cdd:pfam00872   1 MTETHlLLDSEALQAIIELQGKDDLLRTLLKTVMNALLEAELTEHLGAARYERTEERSNQRNGSYSRTFITRAGTLELRI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 622703327   80 PKLRQGSYFPdWLLQRRKRAERALTSVVATCYLLGVSTRRMERLVETLGVTK-LSKSQVSIMAKELDEAVEAFRTRPLDA 158
Cdd:pfam00872  81 PRDRNGSFSP-ALLERYQRRERALDAVVIEMYVSGVSTRKVSDIVEELYGHKsVSKSTVSRITKRLDEAVGAFRNRPLEE 159
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 622703327  159 GPYTFLAADALVLKVREAGRVVGVHTLIATGVNAEGYR 196
Cdd:pfam00872 160 NEYPYLFLDATYLKVREEGRVVSKAVYIAIGIDADGRR 197
transpos_IS256 NF033543
IS256 family transposase; Members of this family belong to the branch of the IS256-like family ...
1-196 4.33e-67

IS256 family transposase; Members of this family belong to the branch of the IS256-like family of transposases that includes the founding member. It excludes the IS1249 group.


Pssm-ID: 468074 [Multi-domain]  Cd Length: 406  Bit Score: 210.54  E-value: 4.33e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 622703327   1 MTSSHLIDTEQLLADQLAQASP-DLLRGLLSTFIAALMGAEADALCGAGYRERSDeRSNQRNGYRHRDFDTRAATIDVAI 79
Cdd:NF033543   4 TAVDELLDEALLGLKALEDLTDdELLRELLKALLEQLLEAELTAHLGAEKYERTG-RGNVRNGYYPRTVLTRGGPVELRV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 622703327  80 PKLRQGSYFPDWLLQRRKRAERALTSVVATCYLLGVSTRRMERLVETLGVTKLSKSQVSIMAKELDEAVEAFRTRPLDaG 159
Cdd:NF033543  83 PRDRDGSFEPQLILKRYRRSEKALEAVIIELYLKGVSTRDIQEALEELYGIDVSSKSVSRLTDAVDEEVEAWQNRPLE-E 161
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 622703327 160 PYTFLAADALVLKVREAGRVVGVHTLIATGVNAEGYR 196
Cdd:NF033543 162 RYPYVFLDATYLKVRDGGRVVNKAVLVALGVDADGKK 198
IS285 COG3328
Transposase (or an inactivated derivative) [Mobilome: prophages, transposons];
10-196 1.00e-66

Transposase (or an inactivated derivative) [Mobilome: prophages, transposons];


Pssm-ID: 442557  Cd Length: 400  Bit Score: 209.67  E-value: 1.00e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 622703327  10 EQLLADQLAQAS--PDLLRGLLSTFIAALMGAEADALCGAGYRERSD-ERSNQRNGYRHRDFDTRAATIDVAIPKLRQGS 86
Cdd:COG3328    9 EELLSELLEGDDlfDDLLRELLKELLEQALEAELDAHLGAEKYERTGgERGNSRNGYRERTVKTRVGELELRVPRDRDGS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 622703327  87 YFPdWLLQRRKRAERALTSVVATCYLLGVSTRRMERLVETLGVTKLSKSQVSIMAKELDEAVEAFRTRPLDaGPYTFLAA 166
Cdd:COG3328   89 FEP-QLLPKYQRREQALEEVIIELYAKGVSTRDIEEALEELYGTGLSKSTVSRITDKLDEEVEAWQNRPLE-ERYPYVYL 166
                        170       180       190
                 ....*....|....*....|....*....|
gi 622703327 167 DALVLKVREAGRVVGVHTLIATGVNAEGYR 196
Cdd:COG3328  167 DAIYLKVREDGRVVNKAVYVALGVNEDGRK 196
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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