NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|622707829|gb|KBC86253|]
View 

hypothetical protein AO89_01676 [Mycobacterium tuberculosis M2140]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 11454890)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

EC:  2.1.1.-
Gene Ontology:  GO:0032259|GO:0008168|GO:1904047
PubMed:  12504684|12826405

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 40-139 1.24e-17

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


:

Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 76.21  E-value: 1.24e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 622707829  40 NKSVLEVGAGIGDHTQFFLDRGCKVLCTEPRGENLDVIRQRfGSNPNVTVDHLDLDgDLPAEAHQYDVVYCYGVLYHLSR 119
Cdd:COG2227   25 GGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARER-AAELNVDFVQGDLE-DLPLEDGSFDLVICSEVLEHLPD 102

                         90       100
                 ....*....|....*....|..
gi 622707829 120 PAEALAWMCDRAVD--LLLLET 139
Cdd:COG2227  103 PAALLRELARLLKPggLLLLST 124
 
Name Accession Description Interval E-value
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 40-139 1.24e-17

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 76.21  E-value: 1.24e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 622707829  40 NKSVLEVGAGIGDHTQFFLDRGCKVLCTEPRGENLDVIRQRfGSNPNVTVDHLDLDgDLPAEAHQYDVVYCYGVLYHLSR 119
Cdd:COG2227   25 GGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARER-AAELNVDFVQGDLE-DLPLEDGSFDLVICSEVLEHLPD 102

                         90       100
                 ....*....|....*....|..
gi 622707829 120 PAEALAWMCDRAVD--LLLLET 139
Cdd:COG2227  103 PAALLRELARLLKPggLLLLST 124
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 43-120 1.10e-12

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 62.20  E-value: 1.10e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 622707829   43 VLEVGAGIGDHTQFFLDR-GCKVLCTEPRGENLDVIRQRFG-SNPNVTVDHLDLDgDLPAEAHQYDVVYCYGVLYHLSRP 120
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRgGARVTGVDLSPEMLERARERAAeAGLNVEFVQGDAE-DLPFPDGSFDLVVSSGVLHHLPDP 79
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
31-95 3.92e-05

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 43.74  E-value: 3.92e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 622707829  31 LATLGLDLGNKSVLEVGAGIGDHTQFFLDRGCKVLCTEpRGENL-DVIRQRFGSNPNVTV---DHLDLD 95
Cdd:PRK14896  21 IVEYAEDTDGDPVLEIGPGKGALTDELAKRAKKVYAIE-LDPRLaEFLRDDEIAAGNVEIiegDALKVD 88
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 43-117 1.34e-04

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 40.11  E-value: 1.34e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 622707829  43 VLEVGAGIGDHTQFFLDR-GCKVLCTEPRGENLDVIRQRF--GSNPNVTVDHLDLDGDLPAEAHQYDVVYCYGVLYHL 117
Cdd:cd02440    2 VLDLGCGTGALALALASGpGARVTGVDISPVALELARKAAaaLLADNVEVLKGDAEELPPEADESFDVIISDPPLHHL 79
rADc smart00650
Ribosomal RNA adenine dimethylases;
43-102 1.47e-03

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 38.26  E-value: 1.47e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 622707829    43 VLEVGAGIGDHTQFFLDRGCKVLCTEprgenLD-----VIRQRFGSNPNVTVDHLD-LDGDLPAEA 102
Cdd:smart00650  17 VLEIGPGKGALTEELLERAKRVTAIE-----IDprlapRLREKFAAADNLTVIHGDaLKFDLPKLQ 77
fkbM_fam TIGR01444
methyltransferase, FkbM family; Members of this family are characterized by two well-conserved ...
 43-92 8.69e-03

methyltransferase, FkbM family; Members of this family are characterized by two well-conserved short regions separated by a variable in both sequence and length. The first of the two regions is found in a large number of proteins outside this subfamily, a number of which have been characterized as methyltransferases. One member of the present family, FkbM, was shown to be required for a specific methylation in the biosynthesis of the immunosuppressant FK506 in Streptomyces strain MA6548.


Pssm-ID: 273628  Cd Length: 143  Bit Score: 35.75  E-value: 8.69e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 622707829   43 VLEVGAGIGDHTQFFLDRG--CKVLCTEPRGENLDVIRQRFGSNPNVTVDHL 92
Cdd:TIGR01444   2 VIDVGANIGDTSLYFARKGaeGRVIAFEPLPDAYEILEENVKLNNLPNVVLL 53
 
Name Accession Description Interval E-value
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 40-139 1.24e-17

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 76.21  E-value: 1.24e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 622707829  40 NKSVLEVGAGIGDHTQFFLDRGCKVLCTEPRGENLDVIRQRfGSNPNVTVDHLDLDgDLPAEAHQYDVVYCYGVLYHLSR 119
Cdd:COG2227   25 GGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARER-AAELNVDFVQGDLE-DLPLEDGSFDLVICSEVLEHLPD 102

                         90       100
                 ....*....|....*....|..
gi 622707829 120 PAEALAWMCDRAVD--LLLLET 139
Cdd:COG2227  103 PAALLRELARLLKPggLLLLST 124
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 26-125 3.03e-14

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 67.71  E-value: 3.03e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 622707829  26 RRQEHLATLGLDlGNKSVLEVGAGIGDHTQFFLDRGCKVLCTEPRGENLDVIRQRFGS-NPNVTVDHLDLDgDLPAEAHQ 104
Cdd:COG2226   10 GREALLAALGLR-PGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEaGLNVEFVVGDAE-DLPFPDGS 87

                         90       100
                 ....*....|....*....|.
gi 622707829 105 YDVVYCYGVLYHLSRPAEALA 125
Cdd:COG2226   88 FDLVISSFVLHHLPDPERALA 108
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 43-120 1.10e-12

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 62.20  E-value: 1.10e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 622707829   43 VLEVGAGIGDHTQFFLDR-GCKVLCTEPRGENLDVIRQRFG-SNPNVTVDHLDLDgDLPAEAHQYDVVYCYGVLYHLSRP 120
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRgGARVTGVDLSPEMLERARERAAeAGLNVEFVQGDAE-DLPFPDGSFDLVVSSGVLHHLPDP 79
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 44-125 1.35e-09

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 53.91  E-value: 1.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 622707829   44 LEVGAGIGDHTQFFLD--RGCKVLCTEPRGENLDVIRQRFGSNPNVTVDHLDLDGDLPAEAH--QYDVVYCYGVLYHLSR 119
Cdd:pfam08242   1 LEIGCGTGTLLRALLEalPGLEYTGLDISPAALEAARERLAALGLLNAVRVELFQLDLGELDpgSFDVVVASNVLHHLAD 80


                  ....*.
gi 622707829  120 PAEALA 125
Cdd:pfam08242  81 PRAVLR 86
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 44-125 2.26e-09

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 53.05  E-value: 2.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 622707829   44 LEVGAGIGDHTQFFLDRGCKVLCTEPRGENLDVIRQRFGSNPNVTVdHLDLDgDLPAEAHQYDVVYCYGVLYHLSRPAEA 123
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREGLTFV-VGDAE-DLPFPDNSFDLVLSSEVLHHVEDPERA 78


                  ..
gi 622707829  124 LA 125
Cdd:pfam08241  79 LR 80
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
39-129 1.38e-07

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 48.28  E-value: 1.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 622707829  39 GNKSVLEVGAGIGDHTQFFLDR--GCKVLCTEPRGENLDVIRQRFgsnPNVTVDHLDLdGDLPAEAhQYDVVYCYGVLYH 116
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALLAERfpGARVTGVDLSPEMLARARARL---PNVRFVVADL-RDLDPPE-PFDLVVSNAALHW 75

                         90
                 ....*....|...
gi 622707829 117 LSRPAEALAWMCD 129
Cdd:COG4106   76 LPDHAALLARLAA 88
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
20-127 5.93e-07

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 48.07  E-value: 5.93e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 622707829  20 YLRHNARRQEHLATLGLDlGNKSVLEVGAGIGDHTQFFLDRGCKVLCTEPRGENLDVIRQRFGSnpnVTVDHLDLdGDLP 99
Cdd:COG4976   28 YEAPALLAEELLARLPPG-PFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREKGVY---DRLLVADL-ADLA 102

                         90       100
                 ....*....|....*....|....*...
gi 622707829 100 AEAHQYDVVYCYGVLYHLSRPAEALAWM 127
Cdd:COG4976  103 EPDGRFDLIVAADVLTYLGDLAAVFAGV 130
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 39-118 1.54e-06

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 47.22  E-value: 1.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 622707829  39 GNKSVLEVGAGIGDHTQFFLDRGC-KVLCTEPRGENLDVIRQRFGSN--PNVTVDHLDLDGDLPAEAHQYDVVYCYGVLY 115
Cdd:COG0500   26 KGGRVLDLGCGTGRNLLALAARFGgRVIGIDLSPEAIALARARAAKAglGNVEFLVADLAELDPLPAESFDLVVAFGVLH 105


                 ...
gi 622707829 116 HLS 118
Cdd:COG0500  106 HLP 108
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 20-151 1.42e-05

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 43.96  E-value: 1.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 622707829   20 YLRHNARR--QEHLATLGLDLGNKSVLEVGAGIGDHTQFFLDRGCKVlcteprgENLDVIRQRFGSNPNVTVDHLDLDGD 97
Cdd:pfam13489   1 YAHQRERLlaDLLLRLLPKLPSPGRVLDFGCGTGIFLRLLRAQGFSV-------TGVDPSPIAIERALLNVRFDQFDEQE 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 622707829   98 LPAEAHQYDVVYCYGVLYHLSRPAEALAWMCDRAVD--LLLLETCVSYSGEDEPFL 151
Cdd:pfam13489  74 AAVPAGKFDVIVAREVLEHVPDPPALLRQIAALLKPggLLLLSTPLASDEADRLLL 129
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
31-95 3.92e-05

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 43.74  E-value: 3.92e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 622707829  31 LATLGLDLGNKSVLEVGAGIGDHTQFFLDRGCKVLCTEpRGENL-DVIRQRFGSNPNVTV---DHLDLD 95
Cdd:PRK14896  21 IVEYAEDTDGDPVLEIGPGKGALTDELAKRAKKVYAIE-LDPRLaEFLRDDEIAAGNVEIiegDALKVD 88
PRK15068 PRK15068
tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB;
30-141 7.89e-05

tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB;


Pssm-ID: 237898  Cd Length: 322  Bit Score: 42.92  E-value: 7.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 622707829  30 HLAtlglDLGNKSVLEVGAGIGDHTQFFL----------DRGCKVLCteprgeNLDVIRQRFGSNPNVtvdHLDLDG--D 97
Cdd:PRK15068 117 HLS----PLKGRTVLDVGCGNGYHMWRMLgagaklvvgiDPSQLFLC------QFEAVRKLLGNDQRA---HLLPLGieQ 183

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 622707829  98 LPAEaHQYDVVYCYGVLYHLSRPAEALAWMCDRAVD--LLLLETCV 141
Cdd:PRK15068 184 LPAL-KAFDTVFSMGVLYHRRSPLDHLKQLKDQLVPggELVLETLV 228
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 43-117 1.34e-04

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 40.11  E-value: 1.34e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 622707829  43 VLEVGAGIGDHTQFFLDR-GCKVLCTEPRGENLDVIRQRF--GSNPNVTVDHLDLDGDLPAEAHQYDVVYCYGVLYHL 117
Cdd:cd02440    2 VLDLGCGTGALALALASGpGARVTGVDISPVALELARKAAaaLLADNVEVLKGDAEELPPEADESFDVIISDPPLHHL 79
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 43-108 1.38e-03

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 38.95  E-value: 1.38e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 622707829  43 VLEVGAGIGDHTQFFLDRGCKVLCTEPRGENLDVIRQRFGSNPNVTV---DHLDLDGDLPAEAHQYDVV 108
Cdd:COG0030   41 VLEIGPGLGALTRALLERAARVTAVEIDRRLAAILRETFAAYPNLTViegDALKVDLPALAAGEPLKVV 109
rADc smart00650
Ribosomal RNA adenine dimethylases;
43-102 1.47e-03

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 38.26  E-value: 1.47e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 622707829    43 VLEVGAGIGDHTQFFLDRGCKVLCTEprgenLD-----VIRQRFGSNPNVTVDHLD-LDGDLPAEA 102
Cdd:smart00650  17 VLEIGPGKGALTEELLERAKRVTAIE-----IDprlapRLREKFAAADNLTVIHGDaLKFDLPKLQ 77
Methyltransf_9 pfam08003
Protein of unknown function (DUF1698); This family contains many hypothetical proteins. It ...
 26-141 4.56e-03

Protein of unknown function (DUF1698); This family contains many hypothetical proteins. It also includes two putative methyltransferase proteins, Swiss:Q8EEE6 and Swiss:Q88MX8.


Pssm-ID: 429781 [Multi-domain]  Cd Length: 315  Bit Score: 37.38  E-value: 4.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 622707829   26 RRQEHLAtlglDLGNKSVLEVGAGIGDHTQFFLDRGCK-VLCTEPRGENL---DVIRQRFGSNPNVTVDHLDLDgDLPAE 101
Cdd:pfam08003 106 RVLPHLS----PLKGRTILDVGCGNGYHMWRMLGEGAAmVVGIDPSELFLcqfEAVRKLLGNDQRAHLLPLGIE-QLPAL 180

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 622707829  102 AhQYDVVYCYGVLYHLSRPAEALAWMCDRAVD--LLLLETCV 141
Cdd:pfam08003 181 A-AFDTVFSMGVLYHRRSPLDHLLQLKDQLVKggELVLETLV 221
fkbM_fam TIGR01444
methyltransferase, FkbM family; Members of this family are characterized by two well-conserved ...
 43-92 8.69e-03

methyltransferase, FkbM family; Members of this family are characterized by two well-conserved short regions separated by a variable in both sequence and length. The first of the two regions is found in a large number of proteins outside this subfamily, a number of which have been characterized as methyltransferases. One member of the present family, FkbM, was shown to be required for a specific methylation in the biosynthesis of the immunosuppressant FK506 in Streptomyces strain MA6548.


Pssm-ID: 273628  Cd Length: 143  Bit Score: 35.75  E-value: 8.69e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 622707829   43 VLEVGAGIGDHTQFFLDRG--CKVLCTEPRGENLDVIRQRFGSNPNVTVDHL 92
Cdd:TIGR01444   2 VIDVGANIGDTSLYFARKGaeGRVIAFEPLPDAYEILEENVKLNNLPNVVLL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH