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Conserved domains on  [gi|633589263|gb|KDD60382|]
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pertactin [Bordetella bronchiseptica OSU553]

Protein Classification

autotransporter outer membrane beta-barrel domain-containing protein( domain architecture ID 11543204)

autotransporter outer membrane beta-barrel domain-containing protein similar to Bordetella pertactin autotransporter, an agglutinogen that binds to eukaryotic cells, which may have a role in bacterial adhesion, and thus play a role in virulence

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
autotrans_barl TIGR01414
outer membrane autotransporter barrel domain; A number of Gram-negative bacterial proteins, ...
467-919 2.50e-110

outer membrane autotransporter barrel domain; A number of Gram-negative bacterial proteins, mostly found in pathogens and associated with virulence, contain a conserved C-terminal domain that integrates into the outer membrane and enables the N-terminal region to be delivered across the membrane. This C-terminal autotransporter domain is about 400 amino acids in length and includes the aromatic amino acid-rich OMP signal, typically ending with a Phe or Trp residue, at the extreme C-terminus. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


:

Pssm-ID: 273608 [Multi-domain]  Cd Length: 431  Bit Score: 346.68  E-value: 2.50e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263  467 AGRFKVLTVNTL-AGSGLFRMNVF--ADLGLSDKLVVMQDASGQHRLWVRNSGSEPASANT-LLLVQTPRGSAATFTLAN 542
Cdd:TIGR01414   2 GGAFNTLTVNGLyTGNGGFVMNTDlgGDNSQTDRLVVNGNASGTTGVVVNNIGGEGAQTGDgITLVTVNGGSDAAFTLAN 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263  543 kdGKVDIGTYRYRLAANG---NGQWSLvgakvppapkpapqpgpqppqppqppqpqpqpqpqPEAPAPQPPAGRELSAAA 619
Cdd:TIGR01414  82 --GKVDAGAYTYTLYKNGtedNNNWYL-----------------------------------TSSLPDLTPPGQQLSPTY 124
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263  620 NAAVNTGGVGLASTLWYAESNALSKRLGELRLNPDAG--GAWGRGFAQRQQLDNRAGR-RFDQKVAGFELGADHAVA-VA 695
Cdd:TIGR01414 125 RAEAGSYAANANAALFLAELDTLRQRMGDLRSAARDAgnGVWARIFGGDNHLDGDAGAaGYDQNTTGVQLGGDILLAgNA 204
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263  696 GGRWHLGGLAGYTRGDRGFT---GDGGGHTDSVHVGGYATYIANSGFYLDATLRASRLENDFKVAGSDGYaVKGKYRTHG 772
Cdd:TIGR01414 205 DGDLHVGLMAGYAKADIKTRsykYGGKGKVDGYGLGLYGTWLQDSGAYVDGVLQYSRFRNDVSSTGSNGK-VSGKYNSNG 283
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263  773 VGASLEAGRRFSHAD-GWFLEPQAELAVFRAGGGAYRAANGLRVRDEGGNSVLGRLGLEVGKRIELAGGRQVQPYIKASV 851
Cdd:TIGR01414 284 FTASLEAGYRYNLGGnGWYVEPQAQLSYFGVSGDDYKESNGTRVLGGGGDSLQGRLGLRVGYQFDLGTGRAVKPYLKANV 363
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 633589263  852 LQEFDGAGTVRTNGIAHRTELRGTRAELGLGMAAALGRGHSLYASYEYSKGPKLAMPWTFHAGYRYSW 919
Cdd:TIGR01414 364 LHEFKGGTGVRVNGVTIRNDFSGTRAEYGVGVNAKIKDNLSLYADVDYQKGGKKYTDNQGNLGVRYSF 431
PL1_Passenger_AT cd01343
Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of ...
327-571 3.53e-58

Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases, SPATEs (serine protease autotransporters secreted by Enterobacteriaceae), Bordetella pertacins, and nonprotease autotransporters, TibA and similar AIDA-like proteins.


:

Pssm-ID: 238653 [Multi-domain]  Cd Length: 233  Bit Score: 199.12  E-value: 3.53e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 327 ARVTVSGGSLSAPHGNVIETGGARRFAPQaaplsITLQAGAHAQGKAllYRVLPEPVKLTLTGgADAQGDIVATElppiP 406
Cdd:cd01343    1 GRLVSDGGNITAGDNAQLTLGGGALYGSS-----VTLTNGAVLDAGN--ANLSAAASYATLSG-SNIRGTVVLGA----G 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 407 GTSSGPLDVALASQARWTGATRAVDS-LSI-DNATWVMTDNSNVGALRLaSDGSVDFQQPAeAGRFKVLTVNTLAGSGLF 484
Cdd:cd01343   69 QPLQALAELLLGGNAAWTGAIQGLNAtVSLnLNSVWTLTGDSNVNNLTL-NGGTVDFNGPS-AGKFNTLTVNTLSGNGTF 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 485 RMNVFADLGLSDKLVVMQDASGQHRLWVRNSGSEPASANTLLLVQTPRGSAATFTLANkdGKVDIGTYRYRLAANGNGQW 564
Cdd:cd01343  147 VMRTDLAGGQGDKLVVTGSATGDFNLLVVNTGKEPTSGLNLTLVSTPKGGDAEFTLAN--GTVDLGAYRYTLVKDGNGNW 224

                 ....*..
gi 633589263 565 SLVGAKV 571
Cdd:cd01343  225 TLTGPKK 231
 
Name Accession Description Interval E-value
autotrans_barl TIGR01414
outer membrane autotransporter barrel domain; A number of Gram-negative bacterial proteins, ...
467-919 2.50e-110

outer membrane autotransporter barrel domain; A number of Gram-negative bacterial proteins, mostly found in pathogens and associated with virulence, contain a conserved C-terminal domain that integrates into the outer membrane and enables the N-terminal region to be delivered across the membrane. This C-terminal autotransporter domain is about 400 amino acids in length and includes the aromatic amino acid-rich OMP signal, typically ending with a Phe or Trp residue, at the extreme C-terminus. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 273608 [Multi-domain]  Cd Length: 431  Bit Score: 346.68  E-value: 2.50e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263  467 AGRFKVLTVNTL-AGSGLFRMNVF--ADLGLSDKLVVMQDASGQHRLWVRNSGSEPASANT-LLLVQTPRGSAATFTLAN 542
Cdd:TIGR01414   2 GGAFNTLTVNGLyTGNGGFVMNTDlgGDNSQTDRLVVNGNASGTTGVVVNNIGGEGAQTGDgITLVTVNGGSDAAFTLAN 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263  543 kdGKVDIGTYRYRLAANG---NGQWSLvgakvppapkpapqpgpqppqppqppqpqpqpqpqPEAPAPQPPAGRELSAAA 619
Cdd:TIGR01414  82 --GKVDAGAYTYTLYKNGtedNNNWYL-----------------------------------TSSLPDLTPPGQQLSPTY 124
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263  620 NAAVNTGGVGLASTLWYAESNALSKRLGELRLNPDAG--GAWGRGFAQRQQLDNRAGR-RFDQKVAGFELGADHAVA-VA 695
Cdd:TIGR01414 125 RAEAGSYAANANAALFLAELDTLRQRMGDLRSAARDAgnGVWARIFGGDNHLDGDAGAaGYDQNTTGVQLGGDILLAgNA 204
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263  696 GGRWHLGGLAGYTRGDRGFT---GDGGGHTDSVHVGGYATYIANSGFYLDATLRASRLENDFKVAGSDGYaVKGKYRTHG 772
Cdd:TIGR01414 205 DGDLHVGLMAGYAKADIKTRsykYGGKGKVDGYGLGLYGTWLQDSGAYVDGVLQYSRFRNDVSSTGSNGK-VSGKYNSNG 283
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263  773 VGASLEAGRRFSHAD-GWFLEPQAELAVFRAGGGAYRAANGLRVRDEGGNSVLGRLGLEVGKRIELAGGRQVQPYIKASV 851
Cdd:TIGR01414 284 FTASLEAGYRYNLGGnGWYVEPQAQLSYFGVSGDDYKESNGTRVLGGGGDSLQGRLGLRVGYQFDLGTGRAVKPYLKANV 363
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 633589263  852 LQEFDGAGTVRTNGIAHRTELRGTRAELGLGMAAALGRGHSLYASYEYSKGPKLAMPWTFHAGYRYSW 919
Cdd:TIGR01414 364 LHEFKGGTGVRVNGVTIRNDFSGTRAEYGVGVNAKIKDNLSLYADVDYQKGGKKYTDNQGNLGVRYSF 431
AidA COG3468
Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular ...
92-919 7.72e-65

Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442691 [Multi-domain]  Cd Length: 846  Bit Score: 234.46  E-value: 7.72e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263  92 NGSVTSSGQLFDDGIRRFLGTVTVKAGKLVADHATLANVGDTWDDDGIALYVAGEQAQASIAASTLQGAGGVQVERGANV 171
Cdd:COG3468   34 GIGNGGGGGAASGSGAGGVAGNGGGGGGGAGGGGGGAGSGGGLAGAGSGGTGGNSTGGGGGNSGTGGTGGGGGGGGSGNG 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 172 TVQRSAIVDGGLHIGALQSLQPEDLPPSRVVLRDTNVTAVPASGAPAAVSVFGANeLTVDGGHITGGRAAGVAAMQGAVV 251
Cdd:COG3468  114 GGGGGGGGGGGTGGGGGGGTGSAGGGGGGGGGGTGVGGTGAAAAGGGTGSGGGGS-GGGGGAGGGGGGGAGGSGGAGSTG 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 252 HLQRATIRRGDAPAGGGVPGGAVPGGFDPGGFGPGGFGPVLDGWYGVDVSGSTVELAQSIVEAPELGAAIRVGRGARVTV 331
Cdd:COG3468  193 SGAGGGGGGSGGGGGAAGTGGGGGGGGGAGGATGGAGSGGNTGGGVGGGGGSAGGTGGGGLTGGGAAGTGGGGGGTGTGS 272
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 332 SGGSLSAPHGNVIETGGARRFAPQAAPLSITLQAGAHAQGKALLYRVLPEPVKLTLTGGADAQGDIVATELPPIP---GT 408
Cdd:COG3468  273 GGGGGGGANGGGSGGGGGASGTGGGGTASTGGGGGGGGGNGGGGGGGSNAGGGSGGGGGGGGGGGGGGTTLNGAGsagGG 352
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 409 SSGPLDVALASQARWTGATRAVDSLSIDNATW------VMTDNSNVGALRLASDGSVDFQQPAEAGRFKVLTVN-TLAGS 481
Cdd:COG3468  353 TGAALAGTGGSGSGGGGGGGSGGGGGAGGGGAntgsdgVGTGLTTGGTGNNGGGGVGGGGGGGLTLTGGTLTVNgNYTGN 432
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 482 -GLFRMNVF--ADLGLSDKLVVMQDASGQHRLWVRNSGSEPA-SANTLLLVQTPRGSAATFTLAnkdGKVDIGTYRYRLA 557
Cdd:COG3468  433 nGTLVLNTVlgDDNSPTDRLVVNGNTSGTTGVRVNNAGGLGAqTVNGIEVVEVNGASDGAFTLG---GRVVAGAYEYTLY 509
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 558 ANGNGQ----WSLVGAKVPPAPKPapqpgpqppqppqppqpqpqpqpqpeapapqppagRELSAAANAAVNTggvgLAST 633
Cdd:COG3468  510 QGGSGGddgnWYLRSTLTPPDPPT-----------------------------------PVYRPEVPSYLAN----PAAA 550
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 634 LWYAESNALSKRLGELRLNP----DAGGAWGRGFAQRQQLDNRAGR-RFDQKVAGFELGADHAVA-VAGGRWHLGGLAGY 707
Cdd:COG3468  551 NGLFELGTLHDRLGERRYTDtgesDNSGAWLRVEGGHNRSRDSSGQlDYDSNRYGLQLGGDLLQWeDGGGRLHVGVMAGY 630
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 708 TRGD----RGFTGDGGGHTDSVHVGGYATYIANSGFYLDATLRASRLENDFKVAGSDGyaVKGKYRTHGVGASLEAGRRF 783
Cdd:COG3468  631 GNGDsdvrSRATGTGKGDVDGYSLGLYGTWYGNNGFYVDGVLQYSWFDNDVSSDDLGG--VTGSYDGNGYSASLEAGYPF 708
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 784 SHADGWFLEPQAELAVFRAGGGAYRAANGLRVRDEGGNSVLGRLGLEVGKRIELAGGRQVQPYIKASVLQEFDGAGTVRT 863
Cdd:COG3468  709 KLGEGWSLEPQAQLIYQGVDFDDFTDSNGTRVSGDDGDSLQGRLGLRLGYEFHWDDGRALQPYLEANWLHEFLGDNSVTV 788
                        810       820       830       840       850
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 633589263 864 NGIAHRTELRGTRAELGLGMAAALGRGHSLYASYEYSKGPK--LAMPWTFHAGYRYSW 919
Cdd:COG3468  789 NGVSFSQDGSGTWGELGLGVTGQLNKNLSLYGDVGYQTGLDgyDSSDTSGNLGVRYSF 846
PL1_Passenger_AT cd01343
Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of ...
327-571 3.53e-58

Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases, SPATEs (serine protease autotransporters secreted by Enterobacteriaceae), Bordetella pertacins, and nonprotease autotransporters, TibA and similar AIDA-like proteins.


Pssm-ID: 238653 [Multi-domain]  Cd Length: 233  Bit Score: 199.12  E-value: 3.53e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 327 ARVTVSGGSLSAPHGNVIETGGARRFAPQaaplsITLQAGAHAQGKAllYRVLPEPVKLTLTGgADAQGDIVATElppiP 406
Cdd:cd01343    1 GRLVSDGGNITAGDNAQLTLGGGALYGSS-----VTLTNGAVLDAGN--ANLSAAASYATLSG-SNIRGTVVLGA----G 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 407 GTSSGPLDVALASQARWTGATRAVDS-LSI-DNATWVMTDNSNVGALRLaSDGSVDFQQPAeAGRFKVLTVNTLAGSGLF 484
Cdd:cd01343   69 QPLQALAELLLGGNAAWTGAIQGLNAtVSLnLNSVWTLTGDSNVNNLTL-NGGTVDFNGPS-AGKFNTLTVNTLSGNGTF 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 485 RMNVFADLGLSDKLVVMQDASGQHRLWVRNSGSEPASANTLLLVQTPRGSAATFTLANkdGKVDIGTYRYRLAANGNGQW 564
Cdd:cd01343  147 VMRTDLAGGQGDKLVVTGSATGDFNLLVVNTGKEPTSGLNLTLVSTPKGGDAEFTLAN--GTVDLGAYRYTLVKDGNGNW 224

                 ....*..
gi 633589263 565 SLVGAKV 571
Cdd:cd01343  225 TLTGPKK 231
Autotransporter pfam03797
Autotransporter beta-domain; Secretion of protein products occurs by a number of different ...
658-898 1.51e-45

Autotransporter beta-domain; Secretion of protein products occurs by a number of different pathways in bacteria. One of these pathways known as the type V pathway was first described for the IgA1 protease. The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C terminus of the proteins it occurs in. The N terminus contains the variable passenger domain that is translocated across the membrane. Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different protease is used and in some cases no cleavage occurs.


Pssm-ID: 461054 [Multi-domain]  Cd Length: 255  Bit Score: 164.48  E-value: 1.51e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263  658 AWGRGFAQRQQLDNRAG-RRFDQKVAGFELGADHAVavaGGRWHLGGLAGYTRGDRGFTGDGG-GHTDSVHVGGYATYIA 735
Cdd:pfam03797   1 VWARGFGGRGKQDGDGGaAGYDADTGGLQVGADYRL---GDNLRLGVAFGYSRSDADVDGRGGsGDSDSYSLGLYGTYYG 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263  736 NSGFYLDATLRASRLENDFK---VAGSDGYAVKGKYRTHGVGASLEAGRRFSHADGWFLEPQAELAVFRAGGGAYR---A 809
Cdd:pfam03797  78 DGGWYLDGGLGYGWHDNDTRrsvDLGGFSETAKGDYDGNGFGASLEAGYRFALGGGWTLEPFAGLAYVRLRLDGFTesgG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263  810 ANGLRVRDEGGNSVLGRLGLEVGKRIELaGGRQVQPYIKASVLQEFDGAGTVRTNGIA----------HRTELRGTRAEL 879
Cdd:pfam03797 158 AAALSVDSQSYDSLTGRLGLRLSYTFDL-GGGTLTPYARLGWRHEFGDDDPVTTAAFAglsgagsftvAGADLARDSLEL 236
                         250
                  ....*....|....*....
gi 633589263  880 GLGMAAALGRGHSLYASYE 898
Cdd:pfam03797 237 GAGLSAQLSDNLSLYANYD 255
Autotransporter smart00869
Autotransporter beta-domain; Secretion of protein products occurs by a number of different ...
660-902 1.74e-39

Autotransporter beta-domain; Secretion of protein products occurs by a number of different pathways in bacteria. One of these pathways known as the type IV pathway was first described for the IgA1 protease. The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C-terminus of the proteins it occurs in. The N-terminus contains the variable passenger domain that is translocated across the membrane. Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different peptidase is used and in some cases no cleavage occurs.


Pssm-ID: 214872 [Multi-domain]  Cd Length: 268  Bit Score: 147.33  E-value: 1.74e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263   660 GRGFAQRQQLDNRAG---RRFDQKVAGFELGADHAVAvAGGRWHLGGLAGYTRGDRGFTGDGG---GHTDSVHVGGYATY 733
Cdd:smart00869   1 GRGLGGFLRQDSSGSggsAGFDYDSYGLQLGADYRLS-DNGNLSLGFAAGYGNSKVDFSGNKGsgkGDVDSYGLGLYAGY 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263   734 IANSGFYLDATLRASRLENDFK--VAGSDGYAVKGKYRTHGVGASLEAGRRFSHADGWFLEPQAELAVFRAGGGAYR--- 808
Cdd:smart00869  80 SLGNGLYLDAQLGYGRSDNDTKrkVTLGGAGRAKGSYDGTGYGASLEAGYRFYLGGGLTLTPFAGLAYSRVRQDGFTesg 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263   809 -AANGLRVRDEGGNSVLGRLGLEVGKRIELAGGRQVQPYIKASVLQEFDGAGTVRTNGIA--------HRTELRGTRAEL 879
Cdd:smart00869 160 gGAFGLSVDSQSLDSLSLPLGLRLEYRLALGDGATLTPYLRLAYVHDFYDDNPVVTASLLgsgasfttSGTDLDRNAAEL 239
                          250       260
                   ....*....|....*....|...
gi 633589263   880 GLGMAAALGRGHSLYASYEYSKG 902
Cdd:smart00869 240 GLGLSAKLSNGLSLSLNYDGEFG 262
PL_Passenger_AT cd00253
Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V ...
408-571 7.69e-29

Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain of autotransporters forms a pore in the outer membrane through which the N-terminal passenger domain is transported. Following transport, the passenger domain is generally cleaved by an outer membrane protease with the passenger domain either remaining in contact with the surface via a noncovalent interaction with the beta domain or cleaved to release a soluble protein. These proteins are highly diverse and perform a variety of functions that promote virulence, including catalyzing proteolysis, serving as an adhesin, mediating actin-promoted motility, or serving as a cytotoxin. Proteins in this family share similarity in the C-terminal region of the passenger domain as seen in the pertactin structure P.69, a Bordetella pertussis agglutinogen responsible for human pertussis. The P.69 protein consists of a 16-stranded parallel beta-helix with a V-shaped cross-section, and is one of the largest beta-helix known to date.


Pssm-ID: 238156 [Multi-domain]  Cd Length: 186  Bit Score: 114.00  E-value: 7.69e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 408 TSSGPLDVALASQARWTGATRAVDS-LSID-NATWVMTDNSNVGALRLASDGSVDFQQPAeaGRFKVLTVN--TLAGSGL 483
Cdd:cd00253   16 TLGGGGALTLTGNSVWLGTLQAGGGtVSLNsNSLWTLTGDSTVNGNLTNSGGTVDFGSAS--GAFNTLTVNgnYLGGNGT 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 484 FRMNV--FADLGLSDKLVVMQDASGQHRLWVRNSGSEPAS-ANTLLLVQTPRGSAATFTLANkdgKVDIGTYRYRLAANG 560
Cdd:cd00253   94 FVLNTdlGGDNSPTDKLVVTGNASGTTNVAVVNAGGEGAStGDGIELVEVNGGSDAAFSLAG---RVDAGAYEYTLYKGG 170
                        170
                 ....*....|....
gi 633589263 561 ---NGQWSLVGAKV 571
Cdd:cd00253  171 vgnNGNWYLRSTLA 184
auto_BafA_Cterm NF040482
BafA family autotransporter C-terminal domain; BafA from both Bartonella henselae and ...
452-918 6.92e-26

BafA family autotransporter C-terminal domain; BafA from both Bartonella henselae and Bartonella quintana, and possibly all Bartonella BafA, are mitogenic autotransporter virulence factors that help induce vasoproliferative lesions during infection. This HMM represents the more conserved C-terminal portion only, as the passenger region is more highly variable in length and sequence.


Pssm-ID: 468508 [Multi-domain]  Cd Length: 617  Bit Score: 113.97  E-value: 6.92e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 452 RLASDGSVDFQQPAEAGRFKVLTVNTLAGSGLFRMNVFADLGLSDKLVVmQDASGQHRLWVRNSGSE--PASANTLLLVq 529
Cdd:NF040482 168 KLSGEGSVIFASTGSDPYYSQLHVNNLSGSLHFKFNTSIAGNRGDYLFI-ENGKGNHTISVADSGVEitDPFSNKRDLI- 245
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 530 TPRGSAATFTLANKDGK----VDIGTYRYRLA--ANGNGQ-WSLvgakvppapkpapqpgpqppqppqPPQPQPQPQPQP 602
Cdd:NF040482 246 TDQSGGANFTLTNLSGEkinaVDGGTYMYGLKqrKDENGKiWYL------------------------SADRISGQESSS 301
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 603 EAPAPQPPAGRELSAAANAAVNTGGVglASTL-WYAESNALSKRLGELRLNPDAGGAWGRGFAQRQQLdnRAGR-RFDQK 680
Cdd:NF040482 302 PDPSEPLSVSDFLTTPSTDAVLSMAV--APGLiFNNELQTVRTGRGILDRNKKNTALWTYAIKSKERI--ATGHtHFKLE 377
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 681 VAGFELGADHAVAVAGGRWHLGGLAGYTRG----DRGftGDGGGHTDSVhvGGYATYIANSGFYLDATLRASRLENDFKV 756
Cdd:NF040482 378 QTGIVLGADGLSELTHGDLYIGGFGSYDQAriahARG--GVSDINTYSI--GAYATYFDHRGWYLDGILKYNYYQNNLKA 453
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 757 AGSDGYAVKGKYRTHGVGASLEAGRRFSHADGWFLEPQAELAVFRAGGGAYRAANGLRVRDEGGNSVLGRLGLEVGKRIE 836
Cdd:NF040482 454 VSTNGLAIQGDYNQWAIGTSFEAGYRFETAQNTWMQPYGQLTWLQVEGKKIKLSNGMTGDISPSTSLRSEVGLSAGHEFI 533
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 837 LAGGRQVQPYIKASVLQEF-DGAGTVRTNGIAHRTELRGTRAELGLGMAAALGRGHSLYASYEYSKGPKLAMPWTFHAGY 915
Cdd:NF040482 534 VGAETSLTAYITAAWLRENiDNNHTTINKQHKFITDLSGNAGKLGIGLNSFVSDKLTLYAEAHYLKGHKIKQSLQGILGL 613

                 ...
gi 633589263 916 RYS 918
Cdd:NF040482 614 RYS 616
PRK15313 PRK15313
intestinal colonization autotransporter adhesin MisL;
642-883 6.45e-13

intestinal colonization autotransporter adhesin MisL;


Pssm-ID: 237940 [Multi-domain]  Cd Length: 955  Bit Score: 72.91  E-value: 6.45e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 642 LSKRLGELRLNPDAGGA------WGRGFAQRQQLDNRAGR---RFDQKVagFELGADHAVAVAGG--RWHLGGLAGYTRG 710
Cdd:PRK15313 657 LHDRLGETQYTDMLTGEkkvtslWMRNVGAHTRFNDGSGQlktRINSYV--LQLGGDLAQWSTDGldRWHIGAMAGYANS 734
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 711 -DRGFTG----DGGGHTDSVHVGGYATYIAN----SGFYLDATLRASRLENdfKVAGSDGYAvkGKYRTHGVGASLEAGR 781
Cdd:PRK15313 735 qNRTLSSvsdyHSRGQVTGYSVGLYGTWYANnidrSGAYVDTWMLYNWFDN--KVMGQDQAA--EKYKSKGITASVEAGY 810
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 782 RF----SHADGWFLEPQAELAVFRAGGGAYRAANGLRVRDEGGNSVLGRLGLEV----GKRIELAGGRQVQPYIKASVLQ 853
Cdd:PRK15313 811 SFrlgeSAHQSYWLQPKAQVVWMGVQADDNREANGTLVKDDTAGNLLTRMGVKAyingHNAIDDNKSREFQPFVEANWIH 890
                        250       260       270
                 ....*....|....*....|....*....|..
gi 633589263 854 EFDGAgTVRTNGIAhrTELRGTR--AELGLGM 883
Cdd:PRK15313 891 NTQPA-SVKMDDVS--SDMRGTKniGELKVGI 919
 
Name Accession Description Interval E-value
autotrans_barl TIGR01414
outer membrane autotransporter barrel domain; A number of Gram-negative bacterial proteins, ...
467-919 2.50e-110

outer membrane autotransporter barrel domain; A number of Gram-negative bacterial proteins, mostly found in pathogens and associated with virulence, contain a conserved C-terminal domain that integrates into the outer membrane and enables the N-terminal region to be delivered across the membrane. This C-terminal autotransporter domain is about 400 amino acids in length and includes the aromatic amino acid-rich OMP signal, typically ending with a Phe or Trp residue, at the extreme C-terminus. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 273608 [Multi-domain]  Cd Length: 431  Bit Score: 346.68  E-value: 2.50e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263  467 AGRFKVLTVNTL-AGSGLFRMNVF--ADLGLSDKLVVMQDASGQHRLWVRNSGSEPASANT-LLLVQTPRGSAATFTLAN 542
Cdd:TIGR01414   2 GGAFNTLTVNGLyTGNGGFVMNTDlgGDNSQTDRLVVNGNASGTTGVVVNNIGGEGAQTGDgITLVTVNGGSDAAFTLAN 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263  543 kdGKVDIGTYRYRLAANG---NGQWSLvgakvppapkpapqpgpqppqppqppqpqpqpqpqPEAPAPQPPAGRELSAAA 619
Cdd:TIGR01414  82 --GKVDAGAYTYTLYKNGtedNNNWYL-----------------------------------TSSLPDLTPPGQQLSPTY 124
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263  620 NAAVNTGGVGLASTLWYAESNALSKRLGELRLNPDAG--GAWGRGFAQRQQLDNRAGR-RFDQKVAGFELGADHAVA-VA 695
Cdd:TIGR01414 125 RAEAGSYAANANAALFLAELDTLRQRMGDLRSAARDAgnGVWARIFGGDNHLDGDAGAaGYDQNTTGVQLGGDILLAgNA 204
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263  696 GGRWHLGGLAGYTRGDRGFT---GDGGGHTDSVHVGGYATYIANSGFYLDATLRASRLENDFKVAGSDGYaVKGKYRTHG 772
Cdd:TIGR01414 205 DGDLHVGLMAGYAKADIKTRsykYGGKGKVDGYGLGLYGTWLQDSGAYVDGVLQYSRFRNDVSSTGSNGK-VSGKYNSNG 283
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263  773 VGASLEAGRRFSHAD-GWFLEPQAELAVFRAGGGAYRAANGLRVRDEGGNSVLGRLGLEVGKRIELAGGRQVQPYIKASV 851
Cdd:TIGR01414 284 FTASLEAGYRYNLGGnGWYVEPQAQLSYFGVSGDDYKESNGTRVLGGGGDSLQGRLGLRVGYQFDLGTGRAVKPYLKANV 363
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 633589263  852 LQEFDGAGTVRTNGIAHRTELRGTRAELGLGMAAALGRGHSLYASYEYSKGPKLAMPWTFHAGYRYSW 919
Cdd:TIGR01414 364 LHEFKGGTGVRVNGVTIRNDFSGTRAEYGVGVNAKIKDNLSLYADVDYQKGGKKYTDNQGNLGVRYSF 431
AidA COG3468
Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular ...
92-919 7.72e-65

Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442691 [Multi-domain]  Cd Length: 846  Bit Score: 234.46  E-value: 7.72e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263  92 NGSVTSSGQLFDDGIRRFLGTVTVKAGKLVADHATLANVGDTWDDDGIALYVAGEQAQASIAASTLQGAGGVQVERGANV 171
Cdd:COG3468   34 GIGNGGGGGAASGSGAGGVAGNGGGGGGGAGGGGGGAGSGGGLAGAGSGGTGGNSTGGGGGNSGTGGTGGGGGGGGSGNG 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 172 TVQRSAIVDGGLHIGALQSLQPEDLPPSRVVLRDTNVTAVPASGAPAAVSVFGANeLTVDGGHITGGRAAGVAAMQGAVV 251
Cdd:COG3468  114 GGGGGGGGGGGTGGGGGGGTGSAGGGGGGGGGGTGVGGTGAAAAGGGTGSGGGGS-GGGGGAGGGGGGGAGGSGGAGSTG 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 252 HLQRATIRRGDAPAGGGVPGGAVPGGFDPGGFGPGGFGPVLDGWYGVDVSGSTVELAQSIVEAPELGAAIRVGRGARVTV 331
Cdd:COG3468  193 SGAGGGGGGSGGGGGAAGTGGGGGGGGGAGGATGGAGSGGNTGGGVGGGGGSAGGTGGGGLTGGGAAGTGGGGGGTGTGS 272
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 332 SGGSLSAPHGNVIETGGARRFAPQAAPLSITLQAGAHAQGKALLYRVLPEPVKLTLTGGADAQGDIVATELPPIP---GT 408
Cdd:COG3468  273 GGGGGGGANGGGSGGGGGASGTGGGGTASTGGGGGGGGGNGGGGGGGSNAGGGSGGGGGGGGGGGGGGTTLNGAGsagGG 352
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 409 SSGPLDVALASQARWTGATRAVDSLSIDNATW------VMTDNSNVGALRLASDGSVDFQQPAEAGRFKVLTVN-TLAGS 481
Cdd:COG3468  353 TGAALAGTGGSGSGGGGGGGSGGGGGAGGGGAntgsdgVGTGLTTGGTGNNGGGGVGGGGGGGLTLTGGTLTVNgNYTGN 432
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 482 -GLFRMNVF--ADLGLSDKLVVMQDASGQHRLWVRNSGSEPA-SANTLLLVQTPRGSAATFTLAnkdGKVDIGTYRYRLA 557
Cdd:COG3468  433 nGTLVLNTVlgDDNSPTDRLVVNGNTSGTTGVRVNNAGGLGAqTVNGIEVVEVNGASDGAFTLG---GRVVAGAYEYTLY 509
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 558 ANGNGQ----WSLVGAKVPPAPKPapqpgpqppqppqppqpqpqpqpqpeapapqppagRELSAAANAAVNTggvgLAST 633
Cdd:COG3468  510 QGGSGGddgnWYLRSTLTPPDPPT-----------------------------------PVYRPEVPSYLAN----PAAA 550
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 634 LWYAESNALSKRLGELRLNP----DAGGAWGRGFAQRQQLDNRAGR-RFDQKVAGFELGADHAVA-VAGGRWHLGGLAGY 707
Cdd:COG3468  551 NGLFELGTLHDRLGERRYTDtgesDNSGAWLRVEGGHNRSRDSSGQlDYDSNRYGLQLGGDLLQWeDGGGRLHVGVMAGY 630
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 708 TRGD----RGFTGDGGGHTDSVHVGGYATYIANSGFYLDATLRASRLENDFKVAGSDGyaVKGKYRTHGVGASLEAGRRF 783
Cdd:COG3468  631 GNGDsdvrSRATGTGKGDVDGYSLGLYGTWYGNNGFYVDGVLQYSWFDNDVSSDDLGG--VTGSYDGNGYSASLEAGYPF 708
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 784 SHADGWFLEPQAELAVFRAGGGAYRAANGLRVRDEGGNSVLGRLGLEVGKRIELAGGRQVQPYIKASVLQEFDGAGTVRT 863
Cdd:COG3468  709 KLGEGWSLEPQAQLIYQGVDFDDFTDSNGTRVSGDDGDSLQGRLGLRLGYEFHWDDGRALQPYLEANWLHEFLGDNSVTV 788
                        810       820       830       840       850
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 633589263 864 NGIAHRTELRGTRAELGLGMAAALGRGHSLYASYEYSKGPK--LAMPWTFHAGYRYSW 919
Cdd:COG3468  789 NGVSFSQDGSGTWGELGLGVTGQLNKNLSLYGDVGYQTGLDgyDSSDTSGNLGVRYSF 846
PL1_Passenger_AT cd01343
Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of ...
327-571 3.53e-58

Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases, SPATEs (serine protease autotransporters secreted by Enterobacteriaceae), Bordetella pertacins, and nonprotease autotransporters, TibA and similar AIDA-like proteins.


Pssm-ID: 238653 [Multi-domain]  Cd Length: 233  Bit Score: 199.12  E-value: 3.53e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 327 ARVTVSGGSLSAPHGNVIETGGARRFAPQaaplsITLQAGAHAQGKAllYRVLPEPVKLTLTGgADAQGDIVATElppiP 406
Cdd:cd01343    1 GRLVSDGGNITAGDNAQLTLGGGALYGSS-----VTLTNGAVLDAGN--ANLSAAASYATLSG-SNIRGTVVLGA----G 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 407 GTSSGPLDVALASQARWTGATRAVDS-LSI-DNATWVMTDNSNVGALRLaSDGSVDFQQPAeAGRFKVLTVNTLAGSGLF 484
Cdd:cd01343   69 QPLQALAELLLGGNAAWTGAIQGLNAtVSLnLNSVWTLTGDSNVNNLTL-NGGTVDFNGPS-AGKFNTLTVNTLSGNGTF 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 485 RMNVFADLGLSDKLVVMQDASGQHRLWVRNSGSEPASANTLLLVQTPRGSAATFTLANkdGKVDIGTYRYRLAANGNGQW 564
Cdd:cd01343  147 VMRTDLAGGQGDKLVVTGSATGDFNLLVVNTGKEPTSGLNLTLVSTPKGGDAEFTLAN--GTVDLGAYRYTLVKDGNGNW 224

                 ....*..
gi 633589263 565 SLVGAKV 571
Cdd:cd01343  225 TLTGPKK 231
Autotransporter pfam03797
Autotransporter beta-domain; Secretion of protein products occurs by a number of different ...
658-898 1.51e-45

Autotransporter beta-domain; Secretion of protein products occurs by a number of different pathways in bacteria. One of these pathways known as the type V pathway was first described for the IgA1 protease. The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C terminus of the proteins it occurs in. The N terminus contains the variable passenger domain that is translocated across the membrane. Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different protease is used and in some cases no cleavage occurs.


Pssm-ID: 461054 [Multi-domain]  Cd Length: 255  Bit Score: 164.48  E-value: 1.51e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263  658 AWGRGFAQRQQLDNRAG-RRFDQKVAGFELGADHAVavaGGRWHLGGLAGYTRGDRGFTGDGG-GHTDSVHVGGYATYIA 735
Cdd:pfam03797   1 VWARGFGGRGKQDGDGGaAGYDADTGGLQVGADYRL---GDNLRLGVAFGYSRSDADVDGRGGsGDSDSYSLGLYGTYYG 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263  736 NSGFYLDATLRASRLENDFK---VAGSDGYAVKGKYRTHGVGASLEAGRRFSHADGWFLEPQAELAVFRAGGGAYR---A 809
Cdd:pfam03797  78 DGGWYLDGGLGYGWHDNDTRrsvDLGGFSETAKGDYDGNGFGASLEAGYRFALGGGWTLEPFAGLAYVRLRLDGFTesgG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263  810 ANGLRVRDEGGNSVLGRLGLEVGKRIELaGGRQVQPYIKASVLQEFDGAGTVRTNGIA----------HRTELRGTRAEL 879
Cdd:pfam03797 158 AAALSVDSQSYDSLTGRLGLRLSYTFDL-GGGTLTPYARLGWRHEFGDDDPVTTAAFAglsgagsftvAGADLARDSLEL 236
                         250
                  ....*....|....*....
gi 633589263  880 GLGMAAALGRGHSLYASYE 898
Cdd:pfam03797 237 GAGLSAQLSDNLSLYANYD 255
Pertactin pfam03212
Pertactin;
448-568 3.76e-45

Pertactin;


Pssm-ID: 460848 [Multi-domain]  Cd Length: 121  Bit Score: 158.33  E-value: 3.76e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263  448 VGALRLaSDGSVDFQQPAE-AGRFKVLTVNTLAGSGLFRMNVFADLGLSDKLVVMQDASGQHRLWVRNSGSEPASANT-L 525
Cdd:pfam03212   1 VAALAL-SGGTVDFASPAEpAGAFKTLTTQTLSGSGTFVMNADVASGTGDQLVVSGNASGQHVLLVRNTGSEPASGNTkL 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 633589263  526 LLVQTPrGSAATFTLANKDGKVDIGTYRYRLAANGNGQWSLVG 568
Cdd:pfam03212  80 TLVETG-GGDAAFTLGNKGGKVDAGTYRYRLTADGNGNWSLTA 121
Autotransporter smart00869
Autotransporter beta-domain; Secretion of protein products occurs by a number of different ...
660-902 1.74e-39

Autotransporter beta-domain; Secretion of protein products occurs by a number of different pathways in bacteria. One of these pathways known as the type IV pathway was first described for the IgA1 protease. The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C-terminus of the proteins it occurs in. The N-terminus contains the variable passenger domain that is translocated across the membrane. Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different peptidase is used and in some cases no cleavage occurs.


Pssm-ID: 214872 [Multi-domain]  Cd Length: 268  Bit Score: 147.33  E-value: 1.74e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263   660 GRGFAQRQQLDNRAG---RRFDQKVAGFELGADHAVAvAGGRWHLGGLAGYTRGDRGFTGDGG---GHTDSVHVGGYATY 733
Cdd:smart00869   1 GRGLGGFLRQDSSGSggsAGFDYDSYGLQLGADYRLS-DNGNLSLGFAAGYGNSKVDFSGNKGsgkGDVDSYGLGLYAGY 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263   734 IANSGFYLDATLRASRLENDFK--VAGSDGYAVKGKYRTHGVGASLEAGRRFSHADGWFLEPQAELAVFRAGGGAYR--- 808
Cdd:smart00869  80 SLGNGLYLDAQLGYGRSDNDTKrkVTLGGAGRAKGSYDGTGYGASLEAGYRFYLGGGLTLTPFAGLAYSRVRQDGFTesg 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263   809 -AANGLRVRDEGGNSVLGRLGLEVGKRIELAGGRQVQPYIKASVLQEFDGAGTVRTNGIA--------HRTELRGTRAEL 879
Cdd:smart00869 160 gGAFGLSVDSQSLDSLSLPLGLRLEYRLALGDGATLTPYLRLAYVHDFYDDNPVVTASLLgsgasfttSGTDLDRNAAEL 239
                          250       260
                   ....*....|....*....|...
gi 633589263   880 GLGMAAALGRGHSLYASYEYSKG 902
Cdd:smart00869 240 GLGLSAKLSNGLSLSLNYDGEFG 262
PL_Passenger_AT cd00253
Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V ...
408-571 7.69e-29

Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain of autotransporters forms a pore in the outer membrane through which the N-terminal passenger domain is transported. Following transport, the passenger domain is generally cleaved by an outer membrane protease with the passenger domain either remaining in contact with the surface via a noncovalent interaction with the beta domain or cleaved to release a soluble protein. These proteins are highly diverse and perform a variety of functions that promote virulence, including catalyzing proteolysis, serving as an adhesin, mediating actin-promoted motility, or serving as a cytotoxin. Proteins in this family share similarity in the C-terminal region of the passenger domain as seen in the pertactin structure P.69, a Bordetella pertussis agglutinogen responsible for human pertussis. The P.69 protein consists of a 16-stranded parallel beta-helix with a V-shaped cross-section, and is one of the largest beta-helix known to date.


Pssm-ID: 238156 [Multi-domain]  Cd Length: 186  Bit Score: 114.00  E-value: 7.69e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 408 TSSGPLDVALASQARWTGATRAVDS-LSID-NATWVMTDNSNVGALRLASDGSVDFQQPAeaGRFKVLTVN--TLAGSGL 483
Cdd:cd00253   16 TLGGGGALTLTGNSVWLGTLQAGGGtVSLNsNSLWTLTGDSTVNGNLTNSGGTVDFGSAS--GAFNTLTVNgnYLGGNGT 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 484 FRMNV--FADLGLSDKLVVMQDASGQHRLWVRNSGSEPAS-ANTLLLVQTPRGSAATFTLANkdgKVDIGTYRYRLAANG 560
Cdd:cd00253   94 FVLNTdlGGDNSPTDKLVVTGNASGTTNVAVVNAGGEGAStGDGIELVEVNGGSDAAFSLAG---RVDAGAYEYTLYKGG 170
                        170
                 ....*....|....
gi 633589263 561 ---NGQWSLVGAKV 571
Cdd:cd00253  171 vgnNGNWYLRSTLA 184
auto_BafA_Cterm NF040482
BafA family autotransporter C-terminal domain; BafA from both Bartonella henselae and ...
452-918 6.92e-26

BafA family autotransporter C-terminal domain; BafA from both Bartonella henselae and Bartonella quintana, and possibly all Bartonella BafA, are mitogenic autotransporter virulence factors that help induce vasoproliferative lesions during infection. This HMM represents the more conserved C-terminal portion only, as the passenger region is more highly variable in length and sequence.


Pssm-ID: 468508 [Multi-domain]  Cd Length: 617  Bit Score: 113.97  E-value: 6.92e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 452 RLASDGSVDFQQPAEAGRFKVLTVNTLAGSGLFRMNVFADLGLSDKLVVmQDASGQHRLWVRNSGSE--PASANTLLLVq 529
Cdd:NF040482 168 KLSGEGSVIFASTGSDPYYSQLHVNNLSGSLHFKFNTSIAGNRGDYLFI-ENGKGNHTISVADSGVEitDPFSNKRDLI- 245
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 530 TPRGSAATFTLANKDGK----VDIGTYRYRLA--ANGNGQ-WSLvgakvppapkpapqpgpqppqppqPPQPQPQPQPQP 602
Cdd:NF040482 246 TDQSGGANFTLTNLSGEkinaVDGGTYMYGLKqrKDENGKiWYL------------------------SADRISGQESSS 301
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 603 EAPAPQPPAGRELSAAANAAVNTGGVglASTL-WYAESNALSKRLGELRLNPDAGGAWGRGFAQRQQLdnRAGR-RFDQK 680
Cdd:NF040482 302 PDPSEPLSVSDFLTTPSTDAVLSMAV--APGLiFNNELQTVRTGRGILDRNKKNTALWTYAIKSKERI--ATGHtHFKLE 377
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 681 VAGFELGADHAVAVAGGRWHLGGLAGYTRG----DRGftGDGGGHTDSVhvGGYATYIANSGFYLDATLRASRLENDFKV 756
Cdd:NF040482 378 QTGIVLGADGLSELTHGDLYIGGFGSYDQAriahARG--GVSDINTYSI--GAYATYFDHRGWYLDGILKYNYYQNNLKA 453
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 757 AGSDGYAVKGKYRTHGVGASLEAGRRFSHADGWFLEPQAELAVFRAGGGAYRAANGLRVRDEGGNSVLGRLGLEVGKRIE 836
Cdd:NF040482 454 VSTNGLAIQGDYNQWAIGTSFEAGYRFETAQNTWMQPYGQLTWLQVEGKKIKLSNGMTGDISPSTSLRSEVGLSAGHEFI 533
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 837 LAGGRQVQPYIKASVLQEF-DGAGTVRTNGIAHRTELRGTRAELGLGMAAALGRGHSLYASYEYSKGPKLAMPWTFHAGY 915
Cdd:NF040482 534 VGAETSLTAYITAAWLRENiDNNHTTINKQHKFITDLSGNAGKLGIGLNSFVSDKLTLYAEAHYLKGHKIKQSLQGILGL 613

                 ...
gi 633589263 916 RYS 918
Cdd:NF040482 614 RYS 616
COG4625 COG4625
Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain [Function ...
50-919 8.03e-15

Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain [Function unknown];


Pssm-ID: 443664 [Multi-domain]  Cd Length: 900  Bit Score: 79.05  E-value: 8.03e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263  50 GIHIQGSDPGGVRTASGTTIKVSGRQAQGILLENPAAELQFRNGSVTSSGQLFDDGIRRFLGTVTVKAGKLVADHATLAN 129
Cdd:COG4625   18 GGGGAGGGGGAGGGAGGGGAGGGGGGGGGGGGAGGGGGGGGTGGGGGGGGGGGGGGAGGGGGGGGGGGGGGGTGGVGGGG 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 130 VGDTWDDDGIALYVAGEQAQASIAASTLQGAGGVQVERGANVTVQRSAIVDGGLHIGALQSLQPEDLPPSRVVLRDTNVT 209
Cdd:COG4625   98 GGGGGGGGGGGGGGGGGGGGSAGGGGGGAGGAGGGGGGGAGGGGGGGGGGGAGGGGGGGAGGAGGGGGGGGGGGGGGGGG 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 210 AVPASGAPAAVSVFGANELTVDGGHITGGRAAGVAAMQGAVVHLQRATIRRGDAPAGGGVPGGAVPGGFDPGGFGPGGFG 289
Cdd:COG4625  178 GGGGGGGGGGGGGGGNGGGGGGGGGGGGGGGGGGGGAGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGAGGGGGGGGG 257
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 290 PVLDGWYGVDVSGSTVELAQSIVEAPELGAAIRVGRGARVTVSGGSLSAPHGNVIETGGARRFAPQAAPLSITLQAGAHA 369
Cdd:COG4625  258 NGGGGGAGGGGGGGGGGSGGGGGGGGGGGSGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGAGGG 337
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 370 QGKALLYRVLPEPVKLTLTGGADAQGDIVATELPPIPGTSSGPLDVALASQARWTGATRAVDSLSIDNATWVMTDNSNVG 449
Cdd:COG4625  338 GGSGGAGAGGGGAGGGGAGGGGGGGTGGGGGGGGGGGGGSGGGGAGGGGGSGGGGGGGAGGGGGGGGAGGTGGGGAGGGG 417
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 450 ALRLASDGSVDFQQPAEAGRFKVLTVNTLAGSGLFRMNVFADLGLSDKLVVMQDASGQHRLWVRNSGSEPASANTLLLVQ 529
Cdd:COG4625  418 GAAGGGGGGTGAGGGGGGGGTGAGGGGATGGGGGGGGGAGGSGGGAGAGGGSGSGAGTLTLTGNNTYTGTTTVNGGGNYT 497
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 530 TPRGSAATFTLANKDGKVDIGTYRYRLAaNGNGQWSLVGAKVPPAPKPAPQPGPQPPQPPQPPQPQPQPQPQPEAPAPQP 609
Cdd:COG4625  498 QSAGSTLAVEVDAANSDRLVVTGTATLN-GGTVVVLAGGYAPGTTYTILAVAAALDALAGNGDLSALYNALAALDAAAAR 576
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 610 PAGRELSAAANAAVNTGGVGLASTLwyaeSNALSKRLGELRLNPDAG-------GAWGRGFAQRQQLDNRAGR-RFDQKV 681
Cdd:COG4625  577 AALDQLSGEIHASAAAALLQASRAL----RDALSNRLRALRGAGAAGdaaaegwGVWAQGFGSWGDQDGDGGAaGYDSST 652
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 682 AGFELGADHAVavaGGRWHLGGLAGYTRGDRGFTGDGG-GHTDSVHVGGYATYIANsGFYLDATLRASRLENDFK---VA 757
Cdd:COG4625  653 GGLLVGADYRL---GDNWRLGVALGYSRSDVDVDDRGSsGDSDSYHLGLYGGYQFG-ALYLDGGLGYGWNDYDTDrtiAF 728
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 758 GSDGYAVKGKYRTHGVGASLEAGRRFsHADGWFLEPQAELAVFRAGGGAYR---AANGLRVRDEGGNSVLGRLGLEVGKR 834
Cdd:COG4625  729 GGLSRTATADYDGDTASAFLEAGYRF-DLGGLTLTPFAGLAYVRLRTDGFTetgGAAALSVDSQSTDSLRSTLGLRASRT 807
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 835 IELAGGRQVQPYIKASVLQEFDGAGTVRTNGIA---------HRTELRGTRAELGLGMAAALGRGHSLYASYEYSKGPKl 905
Cdd:COG4625  808 FSLGGGVTLTPSGRLGWRHEFGDDDPSTTASFAgapgaaftvAGAPLARDALVLGAGLSARLSDGLSLGLGYDGEFGSG- 886
                        890
                 ....*....|....
gi 633589263 906 AMPWTFHAGYRYSW 919
Cdd:COG4625  887 YTDHGGSAGLRYRF 900
PRK15313 PRK15313
intestinal colonization autotransporter adhesin MisL;
642-883 6.45e-13

intestinal colonization autotransporter adhesin MisL;


Pssm-ID: 237940 [Multi-domain]  Cd Length: 955  Bit Score: 72.91  E-value: 6.45e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 642 LSKRLGELRLNPDAGGA------WGRGFAQRQQLDNRAGR---RFDQKVagFELGADHAVAVAGG--RWHLGGLAGYTRG 710
Cdd:PRK15313 657 LHDRLGETQYTDMLTGEkkvtslWMRNVGAHTRFNDGSGQlktRINSYV--LQLGGDLAQWSTDGldRWHIGAMAGYANS 734
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 711 -DRGFTG----DGGGHTDSVHVGGYATYIAN----SGFYLDATLRASRLENdfKVAGSDGYAvkGKYRTHGVGASLEAGR 781
Cdd:PRK15313 735 qNRTLSSvsdyHSRGQVTGYSVGLYGTWYANnidrSGAYVDTWMLYNWFDN--KVMGQDQAA--EKYKSKGITASVEAGY 810
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 782 RF----SHADGWFLEPQAELAVFRAGGGAYRAANGLRVRDEGGNSVLGRLGLEV----GKRIELAGGRQVQPYIKASVLQ 853
Cdd:PRK15313 811 SFrlgeSAHQSYWLQPKAQVVWMGVQADDNREANGTLVKDDTAGNLLTRMGVKAyingHNAIDDNKSREFQPFVEANWIH 890
                        250       260       270
                 ....*....|....*....|....*....|..
gi 633589263 854 EFDGAgTVRTNGIAhrTELRGTR--AELGLGM 883
Cdd:PRK15313 891 NTQPA-SVKMDDVS--SDMRGTKniGELKVGI 919
PRK14849 PRK14849
autotransporter barrel domain-containing lipoprotein;
657-919 3.29e-09

autotransporter barrel domain-containing lipoprotein;


Pssm-ID: 184851 [Multi-domain]  Cd Length: 1806  Bit Score: 61.29  E-value: 3.29e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263  657 GAWGRGFAQRQQLDNRAGRRFdqkvagFELGADHA--VAVAGGRWHLGGLAGY------TRGDR-GFTGDGggHTDSVHV 727
Cdd:PRK14849 1531 GGHERSRAGDGQLNTQANRYV------LQLGGDLAqwSSNAQDRWHLGVMAGYanqhsnTQSNRvGYKSDG--RISGYSA 1602
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263  728 GGYATYIANSGFYLDATLRASRLENDFKVAGSDGYAVKGKYRTHGVGASLEAGRRFSHA---------DGWFLEPQAELA 798
Cdd:PRK14849 1603 GLYATWYQNDANKTGAYVDSWALYNWFDNSVSSDNRSADDYDSRGVTASVEGGYTFEAGtfsgsegtlNTWYVQPQAQIT 1682
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263  799 VFRAGGGAYRAANGLRVRDEGGNSVLGRLG----LEVGKRIELAGGRQVQPYIKASVLQEfDGAGTVRTNGIAHRTELRG 874
Cdd:PRK14849 1683 WMGVKDSDHTRKDGTRIETEGDGNVQTRLGvktyLNSHHQRDDGKQREFQPYIEANWINN-SKVYAVKMNGQTVGREGAR 1761
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 633589263  875 TRAELGLGMAAALGRGHSLYASYEYSKGPKLAMPWTFHAGYRYSW 919
Cdd:PRK14849 1762 NLGEVRTGVEAKVNNNLSLWGNVGVQLGDKGYSDTQGMLGVKYSW 1806
PRK15319 PRK15319
fibronectin-binding autotransporter adhesin ShdA;
491-919 1.63e-08

fibronectin-binding autotransporter adhesin ShdA;


Pssm-ID: 185219 [Multi-domain]  Cd Length: 2039  Bit Score: 58.94  E-value: 1.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263  491 DLGLSDKLVVMQDASGQHRLWVRNSGSEPASANTLLLVQTPRGSAA-TFTLANkdgKVDIGTYRYRLAAN-GNGQWSLV- 567
Cdd:PRK15319 1589 DDSATDKLVITGDASGTTDLYINGIGDGAQTTNGIEVVDVGGVSTSdAFELKN---EVNAGLYTYRLYWNeSDNDWYLAs 1665
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263  568 ----------GAKVPPAPKPAPQPGPQPPQPPQPPQPQPQPQPQPEAPAPQPPAGRELSAAANAAVNT--GGVGLASTLw 635
Cdd:PRK15319 1666 kaqsddddsgGDDTPSDGGDDGGNVTPPDDGGDGGNVTPPDDGGDGGDVTPPDHGGDVAPQYRADIGAymGNQWMARNL- 1744
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263  636 yaESNALSKRLGELRLNPDaGGAWGRGFAQRQQLDNRAGR-RFDQKVAGFELGADhAVAVAGGR--WHLGGLAGYTRGDR 712
Cdd:PRK15319 1745 --QMQTLYDREGSQYRNAD-GSVWARFKAGKAESEAVSGNiDMDSNYSQFQLGGD-ILAWGNGQqsVTVGVMASYINADT 1820
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263  713 GFTGDGG---------GHTDSVHVGGYATYIAN----SGFYLDATLRASRLENDFKvagsDGYAVKGKYRTHGVGASLEA 779
Cdd:PRK15319 1821 DSTGNRGadgsqftssGNVDGYNLGVYATWFADaqthSGAYVDSWYQYGFYNNSVE----SGDAGSESYDSTANAVSLET 1896
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263  780 GRRF----SHADGWFLEPQAELAVFRAGGGAYRAANGLRVRDEGGNSVLGRLGLEVGKRIELAGGRQVQPYIKASVLQEF 855
Cdd:PRK15319 1897 GYRYdialSNGNTVSLTPQAQVVWQNYSADSVKDNYGTRIDGQDGDSWTTRLGLRVDGKLYKGSRTVIQPFAEANWLHTS 1976
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 633589263  856 DGAgTVRTNGIAHRTELRGTRAELGLGMAAALGRGHSLYASYEYSKGPKLAMPWTFHAGYRYSW 919
Cdd:PRK15319 1977 DDV-SVSFDDATVKQDLPANRAELKVGLQADIDKQWSVRAQVAGQTGSNDFGDLNGSLNLRYNW 2039
YhjY COG5571
Uncharacterized conserved protein YhjY, contains autotransporter beta-barrel domain [General ...
649-919 4.23e-08

Uncharacterized conserved protein YhjY, contains autotransporter beta-barrel domain [General function prediction only];


Pssm-ID: 444313 [Multi-domain]  Cd Length: 648  Bit Score: 57.20  E-value: 4.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 649 LRLNPDAGGAWGRGFAQRQQLDNRAGRRFDQKVAGFELGADHAVavaGGRWHLGGLAGYTRGDRGFTGDGGGHTDSVHVG 728
Cdd:COG5571  371 QGRGARGGQTRGGGGAGGTTGGGVGAGGGDGDGPNLTLGVDYRL---SDNLLLGAALSYGRQDLDFGDGGSYDARSTSLS 447
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 729 GYATYIANsGFYLDATLRASRLENDFKVAGSDGYAV---KGKYRTHGVGASLEAGRRFShADGWFLEPQAELAVFRAGGG 805
Cdd:COG5571  448 LYAGYRAG-GLWVDADLSYGDLDYDIRRHIRLGPATrteTGDTDGSQWGARLTAGYDFT-AGRLRTGPFAGLDYQKVKVD 525
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 806 AYR----AANGLRVRDEGGNSVLGRLGLevgkRIELAGGRQVQPYIKASVLQEFDG---AGTVRTNGIAHRT------EL 872
Cdd:COG5571  526 GYTetgaGSTALSFGDQDRDSLVGSLGW----RADYQLLGRFNPYAEVAYEHEFGDddrDVTAGLASLPAGSfslpaaAP 601
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 633589263 873 RGTRAELGLGMAAALGRGHSLYASYEYSKGPKLAMPWTFHAGYRYSW 919
Cdd:COG5571  602 DKNWGRATLGASAALTNGVSLFAGYSGTFGRDDGRQTSVNLGLSARF 648
PL2_Passenger_AT cd01344
Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of ...
385-560 1.45e-07

Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43, AIDA-1 and IcsA, as well as, the less characterized ShdA, MisL, and BapA autotransporters.


Pssm-ID: 238654 [Multi-domain]  Cd Length: 188  Bit Score: 52.69  E-value: 1.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 385 LTLTGGADAQGDIVATElppipgtssGPLDVALASQARWTGATRAVDSLSID-NATWVMTDNSNVGALRLASDGSVDFQQ 463
Cdd:cd01344    3 ITGNGGWKLGGDLTLGG---------GALTLTTSLTLTGTLLTGGAGTLTLDsTSTWNITGTSTLNVGNLTNAGTIDLGN 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 633589263 464 PAEAGrfKVLTVNT--LAGSGLFRMNVF--ADLGLSDKLVVMQDASGQHRLWVRNSGSEPA-SANTLLLVQTpRG--SAA 536
Cdd:cd01344   74 GSPAG--GTLTITGnyTGNGGTLRLNTVlgDDDSPTDRLVIDGDASGTTRVAVNNAGGSGAtTGNGIEVVEV-GGtsSNG 150
                        170       180
                 ....*....|....*....|....
gi 633589263 537 TFTLAnkdGKVDIGTYRYRLAANG 560
Cdd:cd01344  151 AFSLA---GRVVAGAYEYRLYRGG 171
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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