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Conserved domains on  [gi|667705088|gb|KFA57937|]
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iron ABC transporter permease [Mageeibacillus indolicus 0009-5]

Protein Classification

FecCD family ABC transporter permease( domain architecture ID 10001816)

FecCD family ABC transporter permease such as iron ABC transporter permease, which is the transmembrane subunit (TM) found in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter involved in the import of iron and iron-containing compounds

CATH:  1.10.3470.10
Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
SCOP:  4002900
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 27-322 1.41e-92

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 440374  Cd Length: 306  Bit Score: 277.72  E-value: 1.41e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088  27 IGSAGYSLREIVEAIFG-EGSPTVRNILIYLRLPRVIVAIIVGACLATAGALLQAVMRNPLADPGIIGVSAGAGTAATAI 105
Cdd:COG0609    4 LGAVPISLSDVLRALLGpDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAVLA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 106 MLLWPNVST-SVPLFAFCGSLLTCGLIYIMAY-DGTMNPVRIVLAGIAINTVLGGFNALLQ-IMYSDSLSGVLAFLNGSI 182
Cdd:COG0609   84 IVLGGGLSAlGLPLAAFLGALLAALLVYLLARrGGGLSPLRLVLAGVAVSALFSALTSLLLlLADPEQLRSIVFWLMGSL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 183 AASTWSAVRLILAYGVPCLALSFLTIRGANALQLGDEMAVNLGFNVTLTRILISALAAFLSASTVATVGIIGFIGLVVPH 262
Cdd:COG0609  164 AGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLVVPH 243

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 263 IGRIIIGSDYRRLLPISMLMGGLIALVADTVGRVLIEGMELPLGIVMAVAGGPFFLYLLR 322
Cdd:COG0609  244 IARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLR 303
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 27-322 1.41e-92

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 277.72  E-value: 1.41e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088  27 IGSAGYSLREIVEAIFG-EGSPTVRNILIYLRLPRVIVAIIVGACLATAGALLQAVMRNPLADPGIIGVSAGAGTAATAI 105
Cdd:COG0609    4 LGAVPISLSDVLRALLGpDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAVLA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 106 MLLWPNVST-SVPLFAFCGSLLTCGLIYIMAY-DGTMNPVRIVLAGIAINTVLGGFNALLQ-IMYSDSLSGVLAFLNGSI 182
Cdd:COG0609   84 IVLGGGLSAlGLPLAAFLGALLAALLVYLLARrGGGLSPLRLVLAGVAVSALFSALTSLLLlLADPEQLRSIVFWLMGSL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 183 AASTWSAVRLILAYGVPCLALSFLTIRGANALQLGDEMAVNLGFNVTLTRILISALAAFLSASTVATVGIIGFIGLVVPH 262
Cdd:COG0609  164 AGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLVVPH 243

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 263 IGRIIIGSDYRRLLPISMLMGGLIALVADTVGRVLIEGMELPLGIVMAVAGGPFFLYLLR 322
Cdd:COG0609  244 IARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLR 303
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 27-322 7.80e-70

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 220.09  E-value: 7.80e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088   27 IGSAGYSLREIVEAIFGEGSPTVRNILIYLRLPRVIVAIIVGACLATAGALLQAVMRNPLADPGIIGVSAGAGTAATAIM 106
Cdd:pfam01032  12 IGAVKISPSDVFSALLGGDDSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISSGAALGAVLAI 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088  107 LLWPNVST-SVPLFAFCGSLLTCGLIYIMAYDGT-MNPVRIVLAGIAINTVLGGFNALLQIMYS-DSLSGVLAFLNGSIA 183
Cdd:pfam01032  92 LLGGSLSLfALPLAAFIGALLAALLVYFLSRGRGgASPLRLILAGIAVSALLSALTSLLLLLLNpEALQSILFWLMGSLS 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088  184 ASTWSAVRLILAYGVPCLALSFLTIRGANALQLGDEMAVNLGFNVTLTRILISALAAFLSASTVATVGIIGFIGLVVPHI 263
Cdd:pfam01032 172 GANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGPIGFVGLIVPHI 251

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 667705088  264 GRIIIGSDYRRLLPISMLMGGLIALVADTVGRVLIEGMELPLGIVMAVAGGPFFLYLLR 322
Cdd:pfam01032 252 ARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLL 310
btuC PRK09535
cobalamin ABC transporter permease BtuC;
48-322 2.56e-56

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 186.88  E-value: 2.56e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088  48 TVRNILIYLRLPRVIVAIIVGACLATAGALLQAVMRNPLADPGIIGVSAGAGTAATAIMLLWPNVSTSVPLFAFCGSLLT 127
Cdd:PRK09535  86 TAQTIVLQIRLPRILLAATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVGAVAAIVLPLAVPFGLQAAAFAGALVA 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 128 CGLIYIMAYDGTMNPV-RIVLAGIAINTVLGGFNALLQIMYSDSLSGVLAFLNGSIAASTWSAVRLILAYGVPCLALSFL 206
Cdd:PRK09535 166 AFGVYAIATENGRTPVaTLLLAGVAVQTFLGAVISYLLLHSGESLRRAVYWLMGHLHGSTWSDVEVALPVVVVGFVVLLA 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 207 TIRGANALQLGDEMAVNLGFNVTLTRILISALAAFLSASTVATVGIIGFIGLVVPHIGRIIIGSDYRRLLPISMLMGGLI 286
Cdd:PRK09535 246 YARDLNVLLLGEEDAHTLGIEVERTKRLLLALASVVTAAAVAVAGVIGFVGLIVPHVMRLLVGPDHRILLPTSALAGASF 325

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 667705088 287 ALVADTVGRVliEGMELPLGIVMAVAGGPFFLYLLR 322
Cdd:PRK09535 326 LVATDTVARS--GPAEVPVGIVTAALGAPFFLYLLR 359
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 61-321 4.54e-46

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 156.95  E-value: 4.54e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088  61 VIVAIIVGACLATAGALLQAVMRNPLADPGIIGVSAGAGTAATAIMLLWPNVST-SVPLFAFCGSLLTCGLIYIMAYDGT 139
Cdd:cd06550    1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNyALGAFAFAGALAIALLVLLLASRGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 140 MNPVRIVLAGIAINTVLGGFNALLQIMYSDSLSGVLAFLNGSIAASTWSAVRLILAYGVPCLALSFLTIRGANALQLGDE 219
Cdd:cd06550   81 LSPSKLILIGIVLSAFFSAGVILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDED 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 220 MAVNLGFNVTLTRILISALAAFLSASTVATVGIIGFIGLVVPHIGRIIIGSDYRRLLPISMLMGGLIALVADTVGRVLIE 299
Cdd:cd06550  161 LAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTLLP 240

                        250       260
                 ....*....|....*....|..
gi 667705088 300 gMELPLGIVMAVAGGPFFLYLL 321
Cdd:cd06550  241 -SELPVGPVTALLGAPYFLYLL 261
F420-0_ABCperm TIGR03869
proposed F420-0 ABC transporter, permease protein; his small clade of ABC-type transporter ...
 36-327 2.12e-44

proposed F420-0 ABC transporter, permease protein; his small clade of ABC-type transporter permease protein components is found as a three gene cassette along with a periplasmic substrate-binding protein (TIGR03868) and an ATPase (TIGR03873). The organisms containing this cassette are all Actinobacteria and all contain numerous genes requiring the coenzyme F420. This model was defined based on five such organisms, four of which are lacking all F420 biosynthetic capability save the final side-chain polyglutamate attachment step (via the gene cofE: TIGR01916). In Jonesia denitrificans DSM 20603 and marine actinobacterium PHSC20C1 this cassette is in an apparent operon with the cofE gene and, in PHSC20C1, also with an F420-dependent glucose-6-phosphate dehydrogenase (TIGR03554). Based on these observations we propose that this permease protein is a component of a F420-0 (that is, F420 lacking only the polyglutamate tail) transporter.


Pssm-ID: 163581  Cd Length: 325  Bit Score: 154.63  E-value: 2.12e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088   36 EIVEAIFGEGSPTVRNILIY-LRLPRVIVAIIVGACLATAGALLQAVMRNPLADPGIIGVSAGAGTAATAIMLLwpNVST 114
Cdd:TIGR03869  31 GRGEGFPGVALSRLQDAIVWdLRLPRVLTAAAVGAGLAIAGAVMQSLTRNPLADPYLLGLSSGASLGAVAVLVL--GVAV 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088  115 SVPLFAFCGSLLTCGLIYIMAYD-GTMNPVRIVLAGIAINTVLGGFNALLqIMYS---DSLSGVLAFLNGSIAASTWSAV 190
Cdd:TIGR03869 109 LLPVAAFAGALLALAATLGLARTlGTLTPTRTILAGLAVSQLCAAVTSFV-IFWSatgDSYREILSWLMGSLAGATWGSV 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088  191 RLILAYGVPCLALSFLTIRGANALQLGDEMAVNLGFNVTLTRILISALAAFLSASTVATVGIIGFIGLVVPHIGRIIIGS 270
Cdd:TIGR03869 188 AIAGGALLVVGLVLLASGRVLDAFAFGDSSAAALGVDVERTRWLLLTLVALLTGALVSVSGAIGFVGLILPHAVRLLTGP 267

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 667705088  271 DYRRLLPISMLMGGLIALVADTVGRVLIEGMELPLGIVMAVAGGPFFLYLLRSHSHG 327
Cdd:TIGR03869 268 RHRLLLPVSALAGAVFLVWADTLARTVFAPRELPVGIITALIGAPVFAVLLYRSRSG 324
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 27-322 1.41e-92

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 277.72  E-value: 1.41e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088  27 IGSAGYSLREIVEAIFG-EGSPTVRNILIYLRLPRVIVAIIVGACLATAGALLQAVMRNPLADPGIIGVSAGAGTAATAI 105
Cdd:COG0609    4 LGAVPISLSDVLRALLGpDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAVLA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 106 MLLWPNVST-SVPLFAFCGSLLTCGLIYIMAY-DGTMNPVRIVLAGIAINTVLGGFNALLQ-IMYSDSLSGVLAFLNGSI 182
Cdd:COG0609   84 IVLGGGLSAlGLPLAAFLGALLAALLVYLLARrGGGLSPLRLVLAGVAVSALFSALTSLLLlLADPEQLRSIVFWLMGSL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 183 AASTWSAVRLILAYGVPCLALSFLTIRGANALQLGDEMAVNLGFNVTLTRILISALAAFLSASTVATVGIIGFIGLVVPH 262
Cdd:COG0609  164 AGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLVVPH 243

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 263 IGRIIIGSDYRRLLPISMLMGGLIALVADTVGRVLIEGMELPLGIVMAVAGGPFFLYLLR 322
Cdd:COG0609  244 IARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLR 303
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 27-322 7.80e-70

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 220.09  E-value: 7.80e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088   27 IGSAGYSLREIVEAIFGEGSPTVRNILIYLRLPRVIVAIIVGACLATAGALLQAVMRNPLADPGIIGVSAGAGTAATAIM 106
Cdd:pfam01032  12 IGAVKISPSDVFSALLGGDDSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISSGAALGAVLAI 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088  107 LLWPNVST-SVPLFAFCGSLLTCGLIYIMAYDGT-MNPVRIVLAGIAINTVLGGFNALLQIMYS-DSLSGVLAFLNGSIA 183
Cdd:pfam01032  92 LLGGSLSLfALPLAAFIGALLAALLVYFLSRGRGgASPLRLILAGIAVSALLSALTSLLLLLLNpEALQSILFWLMGSLS 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088  184 ASTWSAVRLILAYGVPCLALSFLTIRGANALQLGDEMAVNLGFNVTLTRILISALAAFLSASTVATVGIIGFIGLVVPHI 263
Cdd:pfam01032 172 GANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGPIGFVGLIVPHI 251

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 667705088  264 GRIIIGSDYRRLLPISMLMGGLIALVADTVGRVLIEGMELPLGIVMAVAGGPFFLYLLR 322
Cdd:pfam01032 252 ARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLL 310
FepG COG4779
ABC-type enterobactin transport system, permease component [Inorganic ion transport and ...
 27-321 2.47e-63

ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443810  Cd Length: 344  Bit Score: 204.20  E-value: 2.47e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088  27 IGSAGYSLREIVEAIFGEGSPTVRNILIYLRLPRVIVAIIVGACLATAGALLQAVMRNPLADPGIIGVSAGAGTAATAIM 106
Cdd:COG4779   43 LGDYPLSPGDVLRALLGEGDPGASFVVLELRLPRALAALLVGAALGLSGAIFQSLTRNPLASPDIIGITAGASAGAVAAI 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 107 LLWPNVSTSVPLFAFCGSLLTCGLIYIMAYDGTMNPVRIVLAGIAINTVLGGFNA-LLQIMYSDSLSGVLAFLNGSIAAS 185
Cdd:COG4779  123 VVLGGSGLAVALGALAGGLATALLVYLLAWRGGVSGYRLILVGIGVSAMLTAVNSyLLTRADLEDAQSAAVWLTGSLNGR 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 186 TWSAVRLILAYGVPCLALSFLTIRGANALQLGDEMAVNLGFNVTLTRILISALAAFLSASTVATVGIIGFIGLVVPHIGR 265
Cdd:COG4779  203 TWEDVLPLAVALAVLLPLALALARRLRLLELGDDTAAALGVRVERTRLLLLLVAVALAAVATAAAGPIAFVALAAPQIAR 282

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 667705088 266 IIIGSDYRRLLPiSMLMGGLIALVADTVGRVLIEGMELPLGIVMAVAGGPFFLYLL 321
Cdd:COG4779  283 RLTRSPGPPLLP-SALVGALLLLAADLVAQHLLAPVQLPVGVVTGALGGPYLLWLL 337
btuC PRK09535
cobalamin ABC transporter permease BtuC;
48-322 2.56e-56

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 186.88  E-value: 2.56e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088  48 TVRNILIYLRLPRVIVAIIVGACLATAGALLQAVMRNPLADPGIIGVSAGAGTAATAIMLLWPNVSTSVPLFAFCGSLLT 127
Cdd:PRK09535  86 TAQTIVLQIRLPRILLAATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVGAVAAIVLPLAVPFGLQAAAFAGALVA 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 128 CGLIYIMAYDGTMNPV-RIVLAGIAINTVLGGFNALLQIMYSDSLSGVLAFLNGSIAASTWSAVRLILAYGVPCLALSFL 206
Cdd:PRK09535 166 AFGVYAIATENGRTPVaTLLLAGVAVQTFLGAVISYLLLHSGESLRRAVYWLMGHLHGSTWSDVEVALPVVVVGFVVLLA 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 207 TIRGANALQLGDEMAVNLGFNVTLTRILISALAAFLSASTVATVGIIGFIGLVVPHIGRIIIGSDYRRLLPISMLMGGLI 286
Cdd:PRK09535 246 YARDLNVLLLGEEDAHTLGIEVERTKRLLLALASVVTAAAVAVAGVIGFVGLIVPHVMRLLVGPDHRILLPTSALAGASF 325

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 667705088 287 ALVADTVGRVliEGMELPLGIVMAVAGGPFFLYLLR 322
Cdd:PRK09535 326 LVATDTVARS--GPAEVPVGIVTAALGAPFFLYLLR 359
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
28-322 1.36e-55

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 191.59  E-value: 1.36e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088  28 GSAGYSLREIVEAIFGEGSPTVR-NILIYLRLPRVIVAIIVGACLATAGALLQAVMRNPLADPGIIGVSAGAGTAATAIM 106
Cdd:PRK10577  32 LSAALPLSQWLQALWGPDADDLEqLLLHYSRLPRLAIALLVGAALGLAGALLQQVLRNPLASPTTLGVAAGAQLALVLAT 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 107 LLWPNVSTSVP-LFAFCGSLLTCGLIYIMAYDGTMNPVRIVLAGIAINTVLGGFNALLQIMYSDSLSGVLAFLNGSIAAS 185
Cdd:PRK10577 112 LFAPALLALASqLAAFAGGLLAAALVFALAGGKRLSPLRLVLAGMVVSLYLGALTTLLLLFNEQYLQGLFLWGAGSLAQN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 186 TWSAVRLILAYGVPCLALSFLTIRGANALQLGDEMAVNLGFNVTLTRILISALAAFLSASTVATVGIIGFIGLVVPHIGR 265
Cdd:PRK10577 192 DWSGVQRLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRLAALALAVLLSAAVVSAVGPIGFIGLAAPNLAR 271

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 667705088 266 IIIGSDYRRLLPISMLMGGLIALVADTVGRVL--IEGMELPLGIVMAVAGGPFFLYLLR 322
Cdd:PRK10577 272 LLGARRLRARLPLSPLIGALLLLLTDQLVRLLagVGGELLPTGAVTALIGAPLLLWLLP 330
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
45-322 1.65e-55

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 191.21  E-value: 1.65e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088  45 GSPTVRNILIYLRLPRVIVAIIVGACLATAGALLQAVMRNPLADPGIIGVSAGAGTAATAIMLLWPNVST-SVPLFAFCG 123
Cdd:PRK10577 385 LSGQLLDALLPLRLPRLLAALLAGAMLAVAGTLLQRLTRNPLASPEVLGISSGAGLGVVLALFLVPGAGFgWLLAAALLG 464

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 124 SLLTCGLIYIMAYDGTMNPVRIVLAGIAINTVLGGFNALLQIMYSDSLSGVLAFLNGSIAASTWSAVRLILAYGVPCLAL 203
Cdd:PRK10577 465 ALAALALILLLARRGGFAPERLLLTGIALSALFTALIQLLLASGDPRAAQLLTWLSGSTYGVTWAQALPLLIVAVLLLAL 544

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 204 SFLTIRGANALQLGDEMAVNLGFNVTLTRILISALAAFLSASTVATVGIIGFIGLVVPHIGRIIIGSDYRRLLPISMLMG 283
Cdd:PRK10577 545 ALLLRRWLDLLPLGDDTARALGLPVTRARLALLLLAALLTAAATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLG 624

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 667705088 284 GLIALVADTVGRVLIEGMELPLGIVMAVAGGPFFLYLLR 322
Cdd:PRK10577 625 ALLMVLADWLGRTLLFPYQIPAGLLAALIGAPYFLWLLR 663
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
52-321 4.70e-49

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 166.38  E-value: 4.70e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088  52 ILIYLRLPRVIVAIIVGACLATAGALLQAVMRNPLADPGIIGVSAGAGTAATAIMLLWPNVSTS-VPLFAFCGSLltCGL 130
Cdd:PRK09777  46 VLMEYRLPRLLLALFVGAALAVSGVLVQGIVRNPLASPDILGVNHAASLASVGALLLFPSLPVMwLPLLAFIGGM--AGL 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 131 IYIMAYDGTMNPVRIVLAGIAINTVLGGFNALLQIMYSDSLSGVLAFLNGSIAASTWSAVRLILAYGVPCLALSFLTIRG 210
Cdd:PRK09777 124 ILLKMLAGTHQPMKLALTGVALSALWASLTDYLMLSRPQDINNALLWLTGSLWGRDWSFVKVALPWLILLLPLSLSFCRD 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 211 ANALQLGDEMAVNLGFNVTLTRILISALAAFLSASTVATVGIIGFIGLVVPHIGRIIIGSDYRRLLPISMLMGGLIALVA 290
Cdd:PRK09777 204 LDLLALGDARATTLGVSVPHTQFWALLLAVALTATGVAACGPISFIGLVVPHLMRSLVGGRHRRLLPVSALTGALLLLLA 283

                        250       260       270
                 ....*....|....*....|....*....|.
gi 667705088 291 DTVGRVLIEGMELPLGIVMAVAGGPFFLYLL 321
Cdd:PRK09777 284 DLLARIIHPPLELPAGVLTAIIGAPWFFWLL 314
BtuC COG4139
ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and ...
 46-321 1.69e-47

ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and metabolism];


Pssm-ID: 443314  Cd Length: 327  Bit Score: 162.71  E-value: 1.69e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088  46 SPTVRNILIYLRLPRVIVAIIVGACLATAGALLQAVMRNPLADPGIIGVSAGAGTAATAIMLLWPNVST--SVPLFAFCG 123
Cdd:COG4139   44 SEAWQLFVWQLRLPRTLAAVLVGASLAVSGAVMQALFENPLAEPGLLGISNGAGVGLVLVVLLGGGLLPpwLLSLAAIAG 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 124 SLLTCGLIYIMAYDGtMNPVRIVLAGIAINTVLGGFNALLQIMYSD-SLSGVLAFLNGSIAASTWSAVRLILAYgVPCLA 202
Cdd:COG4139  124 ALLVTLLLLAFARRR-LSNARLLLIGVALGIICSAIMTWAVYFSSSlDLRQLMYWMMGSFGGVDWRQLWLLLAL-LPVLL 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 203 LSFLTIRGANALQLGDEMAVNLGFNVTLTRILISALAAFLSASTVATVGIIGFIGLVVPHIGRIIIGSDYRRLLPISMLM 282
Cdd:COG4139  202 WLCLQGKPLNLLLLGENQARQLGLSVHRWRNLLVLATGLLVGVSVALAGPIGFVGLVVPHLLRLLGTTDHRFLLPACALA 281

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 667705088 283 GGLIALVADTVGRVLIEGMELPLGIVMAVAGGPFFLYLL 321
Cdd:COG4139  282 GAALLLLADIIARLALSSAELPIGVVTATLGAPVFIWLL 320
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 61-321 4.54e-46

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 156.95  E-value: 4.54e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088  61 VIVAIIVGACLATAGALLQAVMRNPLADPGIIGVSAGAGTAATAIMLLWPNVST-SVPLFAFCGSLLTCGLIYIMAYDGT 139
Cdd:cd06550    1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNyALGAFAFAGALAIALLVLLLASRGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 140 MNPVRIVLAGIAINTVLGGFNALLQIMYSDSLSGVLAFLNGSIAASTWSAVRLILAYGVPCLALSFLTIRGANALQLGDE 219
Cdd:cd06550   81 LSPSKLILIGIVLSAFFSAGVILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDED 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 220 MAVNLGFNVTLTRILISALAAFLSASTVATVGIIGFIGLVVPHIGRIIIGSDYRRLLPISMLMGGLIALVADTVGRVLIE 299
Cdd:cd06550  161 LAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTLLP 240

                        250       260
                 ....*....|....*....|..
gi 667705088 300 gMELPLGIVMAVAGGPFFLYLL 321
Cdd:cd06550  241 -SELPVGPVTALLGAPYFLYLL 261
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
41-322 1.27e-45

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 157.93  E-value: 1.27e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088  41 IFGEGSPTVRNILIYLRLPRVIVAIIVGACLATAGALLQAVMRNPLADPGIIGVSAGAGTAATAIMLLWPNVST--SVPL 118
Cdd:PRK11228  35 LPGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGALLQTLTHNPLASPSLLGINSGAALAMALTSALSPTPFAgySLAF 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 119 FAFCGSLLTCGLIYIM--AYDGTMNPVRIVLAGIAINTVLGGFNALLQIMYSDSLSGVLAFLNGSIAASTWSAVRLILAY 196
Cdd:PRK11228 115 IAACGGGLSWLLVMTAggGWRHTHDRNRLILAGIALSALCMALTRITLLLAEDHAYGIFYWLAGGVSHARWQEVWQLLPF 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 197 GVPCLALSFLTIRGANALQLGDEMAVNLGFNVTLTRILISALAAFLSASTVATVGIIGFIGLVVPHIGRIIIGSDYRRLL 276
Cdd:PRK11228 195 VVTAVPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLLVGACVSVAGPVAFIGLLVPHLARFWIGYDQRNVL 274

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 667705088 277 PISMLMGGLIALVADTVGRVLIEGMELPLGIVMAVAGGPFFLYLLR 322
Cdd:PRK11228 275 PMSMLLGATLMLLADLLARALAFPGELPAGAVLALIGAPCFVWLAR 320
F420-0_ABCperm TIGR03869
proposed F420-0 ABC transporter, permease protein; his small clade of ABC-type transporter ...
 36-327 2.12e-44

proposed F420-0 ABC transporter, permease protein; his small clade of ABC-type transporter permease protein components is found as a three gene cassette along with a periplasmic substrate-binding protein (TIGR03868) and an ATPase (TIGR03873). The organisms containing this cassette are all Actinobacteria and all contain numerous genes requiring the coenzyme F420. This model was defined based on five such organisms, four of which are lacking all F420 biosynthetic capability save the final side-chain polyglutamate attachment step (via the gene cofE: TIGR01916). In Jonesia denitrificans DSM 20603 and marine actinobacterium PHSC20C1 this cassette is in an apparent operon with the cofE gene and, in PHSC20C1, also with an F420-dependent glucose-6-phosphate dehydrogenase (TIGR03554). Based on these observations we propose that this permease protein is a component of a F420-0 (that is, F420 lacking only the polyglutamate tail) transporter.


Pssm-ID: 163581  Cd Length: 325  Bit Score: 154.63  E-value: 2.12e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088   36 EIVEAIFGEGSPTVRNILIY-LRLPRVIVAIIVGACLATAGALLQAVMRNPLADPGIIGVSAGAGTAATAIMLLwpNVST 114
Cdd:TIGR03869  31 GRGEGFPGVALSRLQDAIVWdLRLPRVLTAAAVGAGLAIAGAVMQSLTRNPLADPYLLGLSSGASLGAVAVLVL--GVAV 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088  115 SVPLFAFCGSLLTCGLIYIMAYD-GTMNPVRIVLAGIAINTVLGGFNALLqIMYS---DSLSGVLAFLNGSIAASTWSAV 190
Cdd:TIGR03869 109 LLPVAAFAGALLALAATLGLARTlGTLTPTRTILAGLAVSQLCAAVTSFV-IFWSatgDSYREILSWLMGSLAGATWGSV 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088  191 RLILAYGVPCLALSFLTIRGANALQLGDEMAVNLGFNVTLTRILISALAAFLSASTVATVGIIGFIGLVVPHIGRIIIGS 270
Cdd:TIGR03869 188 AIAGGALLVVGLVLLASGRVLDAFAFGDSSAAALGVDVERTRWLLLTLVALLTGALVSVSGAIGFVGLILPHAVRLLTGP 267

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 667705088  271 DYRRLLPISMLMGGLIALVADTVGRVLIEGMELPLGIVMAVAGGPFFLYLLRSHSHG 327
Cdd:TIGR03869 268 RHRLLLPVSALAGAVFLVWADTLARTVFAPRELPVGIITALIGAPVFAVLLYRSRSG 324
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 46-325 3.66e-42

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 148.95  E-value: 3.66e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088  46 SPTVRNILIYLRLPRVIVAIIVGACLATAGALLQAVMRNPLADPGIIGVSAGAGTAATAIMLLWPNVST--SVPLFAFCG 123
Cdd:PRK03784  47 SPRGELFVWQLRLPRTLAVLLVGAALAVSGAVMQALFENPLAEPGLLGVSNGAGVALVAAVLLGQGLLPpwALSLCAIAG 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 124 SLLTCGLIYIMAYDGTMNPVRIVLAGIAINTVlggFNALLQ--IMYSDSLS--GVLAFLNGSIAASTWSAVRLILAYGVP 199
Cdd:PRK03784 127 ALLITLILLRFARRHRLSTSRLLLAGVALGII---CSALMTwaVYFSTSLDlrQLMYWMMGGFGGVDWRQSWLMLALLPV 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 200 CLALSfLTIRGANALQLGDEMAVNLGFNVTLTRILISALAAFLSASTVATVGIIGFIGLVVPHIGRIIIGSDYRRLLPIS 279
Cdd:PRK03784 204 LIWLC-CQGRPLNMLALGEISARQLGLPLWFWRNLLVLATGWLVGVSVALAGAIGFIGLVIPHILRLCGLTDHRVLLPGC 282

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 667705088 280 MLMGGLIALVADTVGRVLIEGMELPLGIVMAVAGGPFFLYLL-RSHS 325
Cdd:PRK03784 283 ALAGASLLLLADIVARLALASAELPIGVVTATLGAPVFIWLLlRSHR 329
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
26-327 1.71e-39

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 142.15  E-value: 1.71e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088  26 RIGSAGYSLREIVEAIFGEGSPTVRNILIYLRLPRVIVAIIVGACLATAGALLQAVMRNPLADPGIIGVSAGAGTAATAI 105
Cdd:PRK10441  29 LIGAKSLPASVVLEALSGTCQSADCTIVLDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLLGVNAGASFAIVLG 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 106 MLLWPNVSTSVPL-FAFCGSLLTCGLIYIMAYDG--TMNPVRIVLAGIAINTVLGGFNALLQIMYSDSLSGVLAFLNGSI 182
Cdd:PRK10441 109 AALFGYSSAQEQLaMAFAGALVASLIVAFTGSQGggQLSPVRLTLAGVALAAVLEGLTSGIALLNPDVYDQLRFWQAGSL 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 183 AASTWSAVRLILAYGVPCLALSFLTIRGANALQLGDEMAVNLGFNVTLTRILISALAAFLSASTVATVGIIGFIGLVVPH 262
Cdd:PRK10441 189 DIRNLHTLKVVLIPVLIAGATALLLSRALNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSATAVVGPIAFIGLMMPH 268

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 667705088 263 IGRIIIGSDYRRLLPISMLMGGLIALVADTVGRVLIEGmELPLGIVMAVAGGPFFLYLLRSHSHG 327
Cdd:PRK10441 269 MARWLVGADHRWSLPVTLLATPALLLFADIIGRLLVPG-ELRVSVVSAFIGAPVLIFLVRRKTRG 332
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
26-328 2.95e-34

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 127.90  E-value: 2.95e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088  26 RIGSAGYSLREIVEAIFGEGSPTVRNILIYLRLPRVIVAIIVGACLATAGALLQAVMRNPLADPGIIGVSAGAGTAATAI 105
Cdd:PRK10440  28 RSGAVTLETSQVFAALMGDAPRSMTMVVTEWRLPRVLMALLIGAALGVSGAIFQSLMRNPLGSPDVMGFNTGAWSGVLVA 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 106 MLLWPNVSTSVPLFAFCGSLLTCGLIYIMAYDGTMNPVRIVLAGIAINTVLGGFNALLQIMYSDSLSGVLAFLN-GSIAA 184
Cdd:PRK10440 108 MVLFGQDLTAIALAAMAGGIVTSLLVWLLAWRNGIDTFRLIIIGIGVRAMLVAFNTWLLLKASLETALTAGLWNaGSLNG 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 185 STWSAVRLILAYGVPCLALSFLTIRGANALQLGDEMAVNLGFNVTLTRILISALAAFLSASTVATVGIIGFIGLVVPHIG 264
Cdd:PRK10440 188 LTWAKTSPSAPIIILMLIAAALLVRRMRLLEMGDDTACALGVSVERSRLLLMLVAVVLTAAATALAGPISFIALVAPHIA 267

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 667705088 265 RIIIGSDyRRLLPISMLMGGLIALVADTVGRVLIEGMELPLGIVMAVAGGPFFLYLLRSHSHGK 328
Cdd:PRK10440 268 RRLSGTA-RWGLTQAALCGALLLLAADLCAQQLFMPYQLPVGVVTVSLGGIYLIVLLIQESRKK 330
cPLA2_Fungal_PLB cd07203
Fungal Phospholipase B-like; cPLA2 GrpIVA homologs; catalytic domain; Fungal phospholipase B ...
 154-239 3.03e-03

Fungal Phospholipase B-like; cPLA2 GrpIVA homologs; catalytic domain; Fungal phospholipase B are Group IV cPLA2 homologs. Aspergillus PLA2 is Ca-dependent, yet it does not contain a C2 domain. PLB deacylates both sn-1 and sn-2 chains of phospholipids and are abundantly expressed in fungi. It shows lysophospholipase (lysoPL) and transacylase activities. The active site residues from cPLA2 are also conserved in PLB. Like cPLA2, PLB also has a consensus sequence of Sm-X-Nu-Sm (Sm = small residue, X = any residue and Nu = nucleophile). It includes PLB1 from Schizosaccharomyces pombe, PLB2 from Candida glabrata, and PLB3 from Saccharomyces cerevisiae. PLB1, PLB2, and PLB3 show PLB and lysoPL activities; PLB3 is specific for phosphoinositides.


Pssm-ID: 132842  Cd Length: 552  Bit Score: 39.27  E-value: 3.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667705088 154 TVLGGfnaLLQ-IMYSDSLSGVlAFLNGSIAASTWSAVRLILAYGVPCLALSFLTIRGANALQ-------LGDEMA--VN 223
Cdd:cd07203   97 HGLGG---LLQsSTYLSGLSGG-SWLVGSLASNNFTSVQDLLADSIWNLDHSIFNPYGAAIVKtlnyytnLANEVAqkKD 172

                         90
                 ....*....|....*.
gi 667705088 224 LGFNVTLTRILISALA 239
Cdd:cd07203  173 AGFNVSLTDIWGRALS 188
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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