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Conserved domains on  [gi|669305280|gb|KFD48830|]
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hypothetical protein M513_10314 [Trichuris suis]

Protein Classification

amidinotransferase domain-containing protein( domain architecture ID 139641)

amidinotransferase domain-containing protein includes glycine and inosamine amidinotransferases, enzymes involved in creatine and streptomycin biosynthesis respectively, and arginine deiminase that catalyzes the reaction: arginine + H2O <=> citrulline + NH3

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DDAH_eukar super family cl19186
N,N dimethylarginine dimethylhydrolase, eukaryotic; This family contains N(G),N(G) ...
 32-179 1.45e-05

N,N dimethylarginine dimethylhydrolase, eukaryotic; This family contains N(G),N(G)-dimethylarginine dimethylaminohydrolases (DDAH) from eukaryotes. It also includes arginine deiminases and DDAH from prokaryotes. These enzymes are involved in arginine metabolism and belong to the amidinotransferase (AT) superfamily as they share the alpha/beta propeller fold, which includes structurally important residues (buried hydrophobic residues, buried hydrophilic residues hydrogen-bonded with mainchain groups and the hallmark of three consecutive buried Gly residues near the C-terminus, conserved among its members.


The actual alignment was detected with superfamily member pfam19420:

Pssm-ID: 473146 [Multi-domain]  Cd Length: 288  Bit Score: 45.44  E-value: 1.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 669305280   32 KQQEELCEKLREAGVDVIELapEDTEELK--SLFVDDLAVVCNGTALITLD-----QPGQRANEVMALLLELGFRVKTLS 104
Cdd:pfam19420  30 KEFDAMVQALRQNGIEVIVL--DDTEPKTpdAVFPNNWFSTHADGTVFLYPmyaenRRLERREDLLELLLEKGFAVYKVL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 669305280  105 NNNNATfCGSDVL-FTGRIVPL--GKEFFVALSERTNMAGAKEIAHTFSEYPVT---AVKLNGSKPlKYY---VCMAAPE 175
Cdd:pfam19420 108 DYSGFE-DESKFLeGTGDMVFDheNKIAYGALSPRADEEVLEEVCREIGYKPVTfhsEVIVDRKGK-PIYhtnVMMNVGE 185


                  ....
gi 669305280  176 VLAV 179
Cdd:pfam19420 186 DLAV 189
 
Name Accession Description Interval E-value
DDAH_eukar pfam19420
N,N dimethylarginine dimethylhydrolase, eukaryotic; This family contains N(G),N(G) ...
 32-179 1.45e-05

N,N dimethylarginine dimethylhydrolase, eukaryotic; This family contains N(G),N(G)-dimethylarginine dimethylaminohydrolases (DDAH) from eukaryotes. It also includes arginine deiminases and DDAH from prokaryotes. These enzymes are involved in arginine metabolism and belong to the amidinotransferase (AT) superfamily as they share the alpha/beta propeller fold, which includes structurally important residues (buried hydrophobic residues, buried hydrophilic residues hydrogen-bonded with mainchain groups and the hallmark of three consecutive buried Gly residues near the C-terminus, conserved among its members.


Pssm-ID: 437252 [Multi-domain]  Cd Length: 288  Bit Score: 45.44  E-value: 1.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 669305280   32 KQQEELCEKLREAGVDVIELapEDTEELK--SLFVDDLAVVCNGTALITLD-----QPGQRANEVMALLLELGFRVKTLS 104
Cdd:pfam19420  30 KEFDAMVQALRQNGIEVIVL--DDTEPKTpdAVFPNNWFSTHADGTVFLYPmyaenRRLERREDLLELLLEKGFAVYKVL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 669305280  105 NNNNATfCGSDVL-FTGRIVPL--GKEFFVALSERTNMAGAKEIAHTFSEYPVT---AVKLNGSKPlKYY---VCMAAPE 175
Cdd:pfam19420 108 DYSGFE-DESKFLeGTGDMVFDheNKIAYGALSPRADEEVLEEVCREIGYKPVTfhsEVIVDRKGK-PIYhtnVMMNVGE 185


                  ....
gi 669305280  176 VLAV 179
Cdd:pfam19420 186 DLAV 189
 
Name Accession Description Interval E-value
DDAH_eukar pfam19420
N,N dimethylarginine dimethylhydrolase, eukaryotic; This family contains N(G),N(G) ...
 32-179 1.45e-05

N,N dimethylarginine dimethylhydrolase, eukaryotic; This family contains N(G),N(G)-dimethylarginine dimethylaminohydrolases (DDAH) from eukaryotes. It also includes arginine deiminases and DDAH from prokaryotes. These enzymes are involved in arginine metabolism and belong to the amidinotransferase (AT) superfamily as they share the alpha/beta propeller fold, which includes structurally important residues (buried hydrophobic residues, buried hydrophilic residues hydrogen-bonded with mainchain groups and the hallmark of three consecutive buried Gly residues near the C-terminus, conserved among its members.


Pssm-ID: 437252 [Multi-domain]  Cd Length: 288  Bit Score: 45.44  E-value: 1.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 669305280   32 KQQEELCEKLREAGVDVIELapEDTEELK--SLFVDDLAVVCNGTALITLD-----QPGQRANEVMALLLELGFRVKTLS 104
Cdd:pfam19420  30 KEFDAMVQALRQNGIEVIVL--DDTEPKTpdAVFPNNWFSTHADGTVFLYPmyaenRRLERREDLLELLLEKGFAVYKVL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 669305280  105 NNNNATfCGSDVL-FTGRIVPL--GKEFFVALSERTNMAGAKEIAHTFSEYPVT---AVKLNGSKPlKYY---VCMAAPE 175
Cdd:pfam19420 108 DYSGFE-DESKFLeGTGDMVFDheNKIAYGALSPRADEEVLEEVCREIGYKPVTfhsEVIVDRKGK-PIYhtnVMMNVGE 185


                  ....
gi 669305280  176 VLAV 179
Cdd:pfam19420 186 DLAV 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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