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Conserved domains on  [gi|682281556|gb|KFY02612|]
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hypothetical protein V490_00447 [Pseudogymnoascus sp. VKM F-3557]

Protein Classification

basic helix-loop-helix domain-containing protein( domain architecture ID 14413049)

basic helix-loop-helix (bHLH) domain-containing protein is a DNA-binding protein that may act as a transcription factor

CATH:  4.10.280.10
Gene Ontology:  GO:0003677|GO:0046983
PubMed:  20219281|15186484|1755826|8018712
SCOP:  4000913

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
bHLH_ScPHO4_like cd11392
basic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae phosphate system ...
 95-171 1.59e-22

basic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae phosphate system positive regulatory protein PHO4 and similar proteins; PHO4 is a transcriptional activator that regulates the expression of repressible phosphatase under phosphate starvation conditions in Saccharomyces cerevisiae. The PHO4 protein has four functional domains with the bHLH domain at its carboxyl-terminal region. It regulates transcription by binding to promoter of the genes as a homodimer.


:

Pssm-ID: 381398  Cd Length: 80  Bit Score: 86.35  E-value: 1.59e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682281556  95 SKRVAHSAAERGRRERLKKALQKLAELMIADRDEDLGGALSS---EFFEAGALAAQTGNKAAIVEMAVEYISSQRKTVVE 171
Cdd:cd11392    1 SKRTAHKVAERGRRDRLNAALKELASLMPAEFVEGKMGADGSasdSNDKEKAAASAAGSKAATVEMAIDYIKHLQKEVEE 80
 
Name Accession Description Interval E-value
bHLH_ScPHO4_like cd11392
basic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae phosphate system ...
 95-171 1.59e-22

basic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae phosphate system positive regulatory protein PHO4 and similar proteins; PHO4 is a transcriptional activator that regulates the expression of repressible phosphatase under phosphate starvation conditions in Saccharomyces cerevisiae. The PHO4 protein has four functional domains with the bHLH domain at its carboxyl-terminal region. It regulates transcription by binding to promoter of the genes as a homodimer.


Pssm-ID: 381398  Cd Length: 80  Bit Score: 86.35  E-value: 1.59e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682281556  95 SKRVAHSAAERGRRERLKKALQKLAELMIADRDEDLGGALSS---EFFEAGALAAQTGNKAAIVEMAVEYISSQRKTVVE 171
Cdd:cd11392    1 SKRTAHKVAERGRRDRLNAALKELASLMPAEFVEGKMGADGSasdSNDKEKAAASAAGSKAATVEMAIDYIKHLQKEVEE 80
HLH pfam00010
Helix-loop-helix DNA-binding domain;
96-164 5.35e-05

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 39.37  E-value: 5.35e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 682281556   96 KRVAHSAAERGRRERLKKALQKLAELMIADRDEdlggalsseffeagalaaQTGNKAAIVEMAVEYISS 164
Cdd:pfam00010   1 RREAHNERERRRRDRINDAFDELRELLPTLPPD------------------KKLSKAEILRLAIEYIKH 51
 
Name Accession Description Interval E-value
bHLH_ScPHO4_like cd11392
basic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae phosphate system ...
 95-171 1.59e-22

basic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae phosphate system positive regulatory protein PHO4 and similar proteins; PHO4 is a transcriptional activator that regulates the expression of repressible phosphatase under phosphate starvation conditions in Saccharomyces cerevisiae. The PHO4 protein has four functional domains with the bHLH domain at its carboxyl-terminal region. It regulates transcription by binding to promoter of the genes as a homodimer.


Pssm-ID: 381398  Cd Length: 80  Bit Score: 86.35  E-value: 1.59e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682281556  95 SKRVAHSAAERGRRERLKKALQKLAELMIADRDEDLGGALSS---EFFEAGALAAQTGNKAAIVEMAVEYISSQRKTVVE 171
Cdd:cd11392    1 SKRTAHKVAERGRRDRLNAALKELASLMPAEFVEGKMGADGSasdSNDKEKAAASAAGSKAATVEMAIDYIKHLQKEVEE 80
HLH pfam00010
Helix-loop-helix DNA-binding domain;
96-164 5.35e-05

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 39.37  E-value: 5.35e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 682281556   96 KRVAHSAAERGRRERLKKALQKLAELMIADRDEdlggalsseffeagalaaQTGNKAAIVEMAVEYISS 164
Cdd:pfam00010   1 RREAHNERERRRRDRINDAFDELRELLPTLPPD------------------KKLSKAEILRLAIEYIKH 51
bHLHzip_SREBP_like cd11395
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding ...
 95-178 1.14e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein (SREBP) family and similar proteins; The SREBP family includes SREBP1 and SREBP2, which are bHLHzip transcriptional activator of genes encoding proteins essential for cholesterol biosynthesis/uptake and fatty acid biosynthesis. SREBP1 and SREBP2 are principally found in the liver and in adipocytes and made up of an N-terminal transcription factor portion (composed of an activation domain, a bHLHzip domain, and a nuclear localization signal), a hydrophobic region containing two membrane spanning regions, and a C-terminal regulatory segment. They recognize a symmetric sterol regulatory element (TCACNCCAC) instead of E-box. The family also includes Saccharomyces cerevisiae transcription factor HMS1 (also termed high-copy MEP suppressor protein 1) and serine-rich protein TYE7. HMS1 is a putative bHLHzip transcription factor involved in exit from mitosis and pseudohyphal differentiation. TYE7, also termed basic-helix-loop-helix protein SGC1, is a putative bHLHzip transcription activator required for Ty1-mediated glycolytic gene expression. TYE7 N-terminal is extremely rich in serine residues. It binds DNA on E-box motifs, 5'-CANNTG-3'. TYE7 is not essential for growth.


Pssm-ID: 381401 [Multi-domain]  Cd Length: 87  Bit Score: 39.24  E-value: 1.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682281556  95 SKRVAHSAAERGRRERLKKALQKLAELMIADRDEDLGgalSSEFFEAGALAAQTGNKAAIVEMAVEYIS---SQRKTVVE 171
Cdd:cd11395    2 RKRLPHNAIEKRYRSNLNTKIERLRDAIPSLRSPEGK---SDDGGLGGLAPTTKLSKATILTKAIEYIRhleQENERLEE 78


                 ....*..
gi 682281556 172 MKSRLKE 178
Cdd:cd11395   79 ENEELRQ 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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