|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
2-393 |
1.54e-56 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 189.70 E-value: 1.54e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 2 RWWGVVTLFVIVAISYVDRINISVLITDhdFLSHIGLTPddrTRQGLLATAFMVGYGVSSFVLTPFcAALFGVRRSLFAG 81
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPT--IMKDLGLSP---TQYGLIASAFFLGYALFQVPGGWL-LDRFGARKVLAVS 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 82 LLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKAHFESRENGKPNSLVNMGTGLGLAVGYPFVGYLVVGH 161
Cdd:cd17319 75 MLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 162 NWETSFHVLGLINVLLGVpLVWAFVRMpkvetgmpkpqsmgeavgqvgqivrgamhtryLWLITILTAAFLSYLWGSSNW 241
Cdd:cd17319 155 GWRWAFIIEGLLGLLLAV-LWWFYLRQ--------------------------------VWGLALGYFGINYALYGLLTW 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 242 LPAYLKESRGFSMREMGWLASLPQYASVAAVFVGGMIIDRIARRQVPLIFVFGSLGVAIAVWLAIHMEDRYAAAYCLIAA 321
Cdd:cd17319 202 LPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLA 281
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 692357228 322 NFCWGLMSPAIPSTVQHCARPEHVASAYGVVNGAGSLVAGFMPAIMGAVIGALsarGGVSAGF-FAGFAALIG 393
Cdd:cd17319 282 GFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDAT---GSYTAAFlFLAAVALLA 351
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
1-410 |
4.17e-46 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 162.35 E-value: 4.17e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 1 MRWWGVVTLFVIVAISYVDRINISVLITDhdFLSHIGLTPddrTRQGLLATAFMVGYGVSSFVLTPFcAALFGVRRSLFA 80
Cdd:COG2271 7 YRWRILALLFLAYFLNYLDRSNLSVAAPP--LQADLGLSA---AQLGLLASAFFLGYALGQIPAGLL-ADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 81 GLLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKAHFESRENGKPNSLVNMGTGLGLAVGYPFVGYLVVG 160
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 161 HNWETSFHVLGLINVLLGVPlvwafvrmpkvetgmpkpqsmgeavgqvgqivrgamhtrYLWLITILTAAFLSYLWGSSN 240
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALL---------------------------------------RFWLLALAYFLVYFALYGFLT 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 241 WLPAYLKESRGFSMREMGWLASLPQYASVAAVFVGGMIIDRIARRQVPLIfVFGSLGVAIAVWLAIHMEDRYAAAYCLIA 320
Cdd:COG2271 202 WLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVL-AIGLLLAALALLLLALLPSPALAIALLFL 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 321 ANFCWGLMSPAIPSTVQHCARPEHVASAYGVVNGAGSLVAGFMPAIMGAVIGALsarggvsaGFFAGFAALIGTQVIVML 400
Cdd:COG2271 281 AGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT--------GYQAAFLLLAALALLAAL 352
|
410
....*....|
gi 692357228 401 CGIVLWVRER 410
Cdd:COG2271 353 LALLLLRETR 362
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
2-415 |
8.52e-36 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 135.39 E-value: 8.52e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 2 RWWGVVTLFVIVAISYVDRINISVLITDhdFLSHIGLTPDDrtrQGLLATAFMVGYGVSSFVLTPFCAaLFGVRRSLFAG 81
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPP--LAEEFGLSAAQ---LGLLFAIPVLVGALLRIPLGFLVD-RFGPRRVLLIG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 82 LLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKAHFESRENGKPNSLVNMGTGLGLAVGYPFVGYLVVGH 161
Cdd:COG2223 77 LLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 162 NWETSFHVLGLInVLLGVPLVWAFVRMPKVETGMPKPQSMGEAvgqvgqivRGAMHTRYLWLITILTAAFLSYLWGSSNW 241
Cdd:COG2223 157 GWRNAFLILGIL-LLVVAVLAWLFLRDPPAGAAAAAKASLRDQ--------LEALRDPRFWLLSLLYFGTFGSFIGFSSW 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 242 LPAYLKESRGFSMREMGWLASLPQYASVAAVFVGGMIIDRIARRQVplIFVFGSLGVAIAVWLAIHMEDRYAAAYCLIAA 321
Cdd:COG2223 228 LPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRV--LLIVFALMALGLLLLALALGSLWLFLVLFLLL 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 322 NFCWGLMSPAIPSTVQHCARPEHVASAYGVVNGAGSLVAGFMPAIMGAVIGAlsarggvSAGFFAGFAALIGTQVIVMLC 401
Cdd:COG2223 306 GLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDA-------TGSYTAAFLVFAVLALVALVL 378
|
410
....*....|....
gi 692357228 402 GIVLWVRERGEGSA 415
Cdd:COG2223 379 TLLLYRRPRRAAAA 392
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
9-364 |
2.26e-27 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 111.36 E-value: 2.26e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 9 LFVIVAISYVDRINISVLITDHdFLSHIGLTPDDrtrQGLLATAFMVGYGVSSFVLTPFcAALFGVRRSLFAGLLLWGVV 88
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLL-LAEDLGISPTE---IGLLLTLFSLGYALAQPLAGRL-SDRFGRRRVLLIGLLLFALG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 89 TFLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKAHFESRENGKPNSLVNMGTGLGLAVGYPFVGYLVVGHNWETSFH 168
Cdd:pfam07690 76 LLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 169 VLGLINVLLGVPLVwafvrMPKVETGMPKPQSMGEAVGQVGQIVRGAMHTRYLWLITILTAAFLSYlWGSSNWLPAYLkE 248
Cdd:pfam07690 156 ILAILSLLAAVLLL-----LPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAF-FGLLTYLPLYQ-E 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 249 SRGFSMREMGWLASLPQYASVAAVFVGGMIIDRIARRQVPLIFVFGSLGVAIAVWLAIHMEDRYAAAYCLIAANFCWGLM 328
Cdd:pfam07690 229 VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLV 308
|
330 340 350
....*....|....*....|....*....|....*.
gi 692357228 329 SPAIPSTVQHCARPEHVASAYGVVNGAGSLVAGFMP 364
Cdd:pfam07690 309 FPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
2-358 |
1.40e-26 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 109.29 E-value: 1.40e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 2 RWWGVVTLFVIVAISYVDRINISVLITDhdFLSHIGLTPddrTRQGLLATAFMVGYGVSSFVLTPFcAALFGVRRSLFAG 81
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPL--IAADLGASP---AQAGLVVTAYLLGAALGAPLAGRL-ADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 82 LLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKAHFESRENGKPNSLVNMGTGLGLAVGYPFVGYLVVGH 161
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 162 NWETSFHVLGLINVLLGVPLVWAFvrmpkvetgmpkPQSMGEAVGQVGQIVRGAMHTRYLWLITILTAAFLSYLWGSSNW 241
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLL------------PESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTY 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 242 LPAYLKESRGFSMREMGWLASLPQYASVAAVFVGGMIIDRIARRQVpliFVFGSLGVAIAVWLAIHMEDRYAAAYCLIAA 321
Cdd:COG2814 230 LPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRL---LLIGLLLLALGLLLLALAGSLWLLLLALFLL 306
|
330 340 350
....*....|....*....|....*....|....*..
gi 692357228 322 NFCWGLMSPAIPSTVQHCARPEHVASAYGVVNGAGSL 358
Cdd:COG2814 307 GFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
47-405 |
1.51e-25 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 107.27 E-value: 1.51e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 47 GLLATAFMVGYGVSSFvLTPFCAALFGVRRSLFAGLLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKAH 126
Cdd:COG2807 56 GLLTTLPLLAFGLFAP-LAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRW 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 127 FESReNGKPNSLVNMGTGLGLAVGYPFVGYLVVGHNWETSFHVLGLINVLLGVPLVWAFVRMPKVETGMPKPQSmgeavg 206
Cdd:COG2807 135 FPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAAS------ 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 207 qvgqiVRGAMHTRYLWLITILTAAFLSYLWGSSNWLPAYLkESRGFSMREMGWLASLPQYASVAAVFVGGMIIDRIARRQ 286
Cdd:COG2807 208 -----LRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPIL-RDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRR 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 287 VPLIFVFGSLGVAIAVWLAIHMEDRYAAAyclIAANFCWGLMSPAIPS-TVQHCARPEHVASAYGVVNGAGSLVAGFMPA 365
Cdd:COG2807 282 PLLLLLGLLGLAGLLGLLLAPGSLPWLWA---VLLGLGQGGLFPLALTlIGLRARTPAEAAALSGMAQSVGYLLAALGPL 358
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 692357228 366 IMGAVIGAlsarggvSAGFFAGFAALIGTQVIVMLCGIVL 405
Cdd:COG2807 359 LVGALHDA-------TGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
6-406 |
6.15e-23 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 99.62 E-value: 6.15e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 6 VVTLFVIVAISYVDRINISVLITD--HDFLShigltpdDRTRQGLLATAFMVGYGVSSfvltPFCAAL---FGVRRSLFA 80
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDiqSDFLI-------DDSLAGLLQTVFIISYMVLS----PIFGYLgdrYNRKWILAV 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 81 GLLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKAHFESRENGKPNSLVNMGTGLGLAVGYPfVGYLVVG 160
Cdd:cd17328 70 GILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYV-VGGLVAQ 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 161 HN--WETSFHVLGLINVLLGVpLVWAFVRmpkvetgMPKPQSMGEAVGQVGQIVRGAMHTRYL-----WLITILTAAFLS 233
Cdd:cd17328 149 ATggWRWAFRVTGVLGVLLAI-LLLLFVR-------EPPRGAAEGGVMAKSTATSFLADLKALaknpsFILSTLGFTAVS 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 234 YLWGS-SNWLPAYLKESRGFSMREMG----WLASLPQYASVAAVFVGGMIIDRIARRQV---PLIFVFGSLGVAIAVWLA 305
Cdd:cd17328 221 FVTGAlAFWAPTFFLRAFGVGDLSSAdvglIFGAITCIAGVLGVLLGGILADRLRRKTPradPLVCAVGLLAAAPFLFLA 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 306 IHM--EDRYAAAYCLIAANFCWGLMSPAIPSTVQHCARPEHVASAYGVVNGAGSLVA-GFMPAIMGAVIGALSARGG-VS 381
Cdd:cd17328 301 LVLalSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGdAGSPYLIGLISDLLRQNKDsPL 380
|
410 420
....*....|....*....|....*
gi 692357228 382 AGFFAGFAALIGTQVIVMLCGIVLW 406
Cdd:cd17328 381 AEAASLQYALLLCSFVLVLGGFFFL 405
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
10-371 |
3.09e-22 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 97.45 E-value: 3.09e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 10 FVIVAISYVDRINISVLITDhdFLSHIGLTPDDrtrQGLLATAFMVGYGVSSFVLTPFcAALFGVRRSLFAGLLLWGVVT 89
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPY--LVEEIGLSKTD---LGLLLSSFSIAYGISKFVMGSV-SDRSNPRVFLPIGLILCAIVN 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 90 FLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKAHFESRENGKPNSLVNMGTGLGLAVGYPFVGYLVVGHN-WETSFH 168
Cdd:TIGR00881 75 LFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYsWHWVFI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 169 VLGLINVLLGVPLVWaFVRMPKVETGMPK-PQSMGEAVGQVGQIVRGAMHT-----------RYLWLITILTAAFLSYLW 236
Cdd:TIGR00881 155 VPGIIAIIVSLICFL-LLRDSPQSCGLPPaEEMPNEEPDGDAEKKEEELTKkqiflqyvllnKVLWYISLGYVFVYVVRT 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 237 GSSNWLPAYLKESRGFSMREMGWLASLPQYASVAAVFVGGMIIDRIARRQVPLIFVFGSLGVAIAVWLAIHM--EDRYAA 314
Cdd:TIGR00881 234 GILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALIIVSLLVYWLNpaANPLMD 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 692357228 315 AYCLIAANFCWGLMSPAIPSTVQHCARPEHVASAYGVVNGAGSLVAGFMPAIMGAVI 371
Cdd:TIGR00881 314 LICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLA 370
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
46-392 |
6.84e-22 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 96.11 E-value: 6.84e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 46 QGLLATAFMVGYGVSSFVLTPFCAAL--------FGVRRSLFAGLLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFS 117
Cdd:cd17325 24 ESLGASVAQIGLIVAAYALAQLLFSPpagrlsdrFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 118 LAGSYIKAHFESRENGKPNSLVNMGTGLGLAVGYPFVGYLVVGHNWETSFHVLGLInVLLGVPLVWAFvrmpkVETGMPK 197
Cdd:cd17325 104 AAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL-ALLALVLALLL-----LPEPRPP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 198 PQSMGEAVGQVGQIVRGAMHTRYLWLITILTAAFLSYLWGSSNWLPAYLKESRGFSMREMGWLASLPQYASVAAVFVGGM 277
Cdd:cd17325 178 PNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGK 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 278 IIDRIARRQVpliFVFGSLGVAIAVWLAIHMEDRYAAAYCLIAANFCWGLMSPAIPSTVQHCARPEHVASAYGVVNGAGS 357
Cdd:cd17325 258 LSDRIGRKPL---ILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFS 334
|
330 340 350
....*....|....*....|....*....|....*..
gi 692357228 358 LVAGFMPAIMGAVIGALSARGG--VSAGFFAGFAALI 392
Cdd:cd17325 335 LGMVLGPLLGGFLYDAFGFATPflAAAALLLLAAVLF 371
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
47-392 |
1.14e-20 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 92.87 E-value: 1.14e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 47 GLLATAFMVGYGVSSFVLTPFcAALFGVRRSLFAGLLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKAH 126
Cdd:cd06174 34 GLLFALFSLGYALLQPLAGLL-ADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 127 FESRENGKPNSLVNMGTGLGLAVGYPFVGYLVVGHNWetSFHVLGLINVLLGVPLVWAFVRMPKVETGMPKPQSMGEAVG 206
Cdd:cd06174 113 FPERERGRALGLLQAFGSVGGILGPLLGGILASSLGF--GWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSK 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 207 QVGQIVRGAMHTRYLWLITILTAAFLSYLWGSSNWLPAYLKESRGFSMREMGWLASLPQYASVAAVFVGGMIIDRIARRq 286
Cdd:cd06174 191 SVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGR- 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 287 vPLIFVFGSLGVAIAVWLAIHMEDRYAAAYCLIAANFCWGLMSPAIPSTVQHCARPEHVASAYGVVNGAGSLVAGFMPAI 366
Cdd:cd06174 270 -KPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLL 348
|
330 340
....*....|....*....|....*.
gi 692357228 367 MGAVigaLSARGGVSAGFFAGFAALI 392
Cdd:cd06174 349 AGFL---LAATFGLTGAFLVLAVLLL 371
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
47-379 |
2.08e-19 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 89.14 E-value: 2.08e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 47 GLLATAFMVGYGVSSFvLTPFCAALFGVRRSLFAGLLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKAH 126
Cdd:COG0738 46 GLLLFAFFLGYLLASL-PAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAAL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 127 FesRENGKPN-SLVNMGTGLGLAVGyPFVGYLVVGHNWETSFHVLGLINVLLGVPLVWAFVRMPkvetgMPKPQSMGEAV 205
Cdd:COG0738 125 G--PETAASRlNLLHAFFSLGALLG-PLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFLRSK-----LPEIEEEEEEA 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 206 GQVGQIVRGAMHTRYLWLITILTAAFLSYLWGSSNWLPAYLKESRGFSMREMGWLASLPQYASVAAVFVGGMIIDRIARR 285
Cdd:COG0738 197 AGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPV 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 286 QVpliFVFGSLGVAIAVWLAIHMEDRYAAAYCLIAANFCWGLMSPAIPSTVQHCArPEHVASAYGVVNGAGSLVAGFMPA 365
Cdd:COG0738 277 RL---LRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGL-GKRTAAAVSAVLIMGIVGGAIGPP 352
|
330
....*....|....
gi 692357228 366 IMGAVIGALSARGG 379
Cdd:COG0738 353 LIGFLADAFGLRAA 366
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
6-362 |
1.36e-18 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 86.45 E-value: 1.36e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 6 VVTLFVIVAISYVDRINISVLIT--DHDFLShigltpdDRTRQGLLATAFMVGYgVSSFVLTPFCAALFGVRRSLFAGLL 83
Cdd:cd17380 1 VILLFLATCICYADRVNMPIAIVpmAKEFGW-------SKTDQGLVLSSFFWGY-ALTQVLGGYLADRFGGKKVLLLAVA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 84 LWGVVTFLSP--AMNSYGLLLASRILLGVSEGPLFSLAGSYIKAHFESRENGKPNSLVNMGTGLGLAVGYPFVGYLVVGH 161
Cdd:cd17380 73 LWSLATLLTPllAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYY 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 162 NWETSFHVLGLINVLLGvpLVWAFVRMPkvetgmpkpqsmgeavgqvgqivrgamhtryLWLITIltaAFLSYLWGSS-- 239
Cdd:cd17380 153 GWPSVFYFFGLLGLLWA--LVWLIYLPP-------------------------------VWAIIV---AHFCMNWGFYil 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 240 -NWLPAYLKEsRGFSMREMGWLASLPQYASVAAVFVGGMIIDRIARRQVPLIFV------FGSLGVAIAVWLAIHMEDRY 312
Cdd:cd17380 197 lSWLPTYFHE-VLVPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSVrklmqsIGFLGPALFLLLLSHTDSFS 275
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 692357228 313 AAAYCLIAANFCWGLMSPAIPSTVQHCArPEHVASAYGVVNGAGSLvAGF 362
Cdd:cd17380 276 LALLCMSVALGLSAFSSSGVLVNHQDIA-PNYAGIVFGISNTAGTI-PGI 323
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
47-392 |
2.66e-18 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 85.68 E-value: 2.66e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 47 GLLATAFMVGYGVSSFVLTPFcAALFGVRRSLFAGLLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKAH 126
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPL-SDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 127 FESRENGKPNSLVNMGTGLGLAVGYPFVGYLVVGHNWETSFHVLGLINVLLGVPLVWAFVRMPKVETGMPKPQSMgeavg 206
Cdd:cd17324 116 VPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSS----- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 207 qvgqiVRGAMHTRYLWLITILTAAFLSYLWGSSNWLPAYLKESRGFSMREMGWLASLPQYASVAAVFVGGMIIDRIARRq 286
Cdd:cd17324 191 -----LLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRR- 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 287 vpliFVFGSLGVAIAVWLAIHMEDRYAAAycLIAANFCWGLMSPAIPSTVQHCA---RPEHVASAYGVVNGAGSLVAGFM 363
Cdd:cd17324 265 ----ALLIALLLLAAALLLLTLLGPSPLL--LLVGLVLWGLGFFAAHSALQTRVlrlAPEARGLASSLYLAAYNLGGALG 338
|
330 340
....*....|....*....|....*....
gi 692357228 364 PAIMGAVIGALSARGGVSAGFFAGFAALI 392
Cdd:cd17324 339 AALGGLVLDHGGWAGVGWVGAALLLLALL 367
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
7-371 |
1.47e-15 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 77.66 E-value: 1.47e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 7 VTLFVIVAISYVDRINISVLI---------TDHDFLSHIGLTPDDRTR--------QGLLATAFMVGYGVSSFVLTPFcA 69
Cdd:cd17318 2 ILLFLGFAVVYAMRVNLSVAIvamvnstatHDNNNTSTDKDTLPVEAPefdwsektQGIILSSFFYGYILTQIPGGYL-A 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 70 ALFGVRRSLFAGLLLWGVVTFLSPAMN--SYGLLLASRILLGVSEGPLFSLAGSYIKAHFESRENGKPNSLVNMGTGLGL 147
Cdd:cd17318 81 EKYGAKRVLGYSILITALLTLLTPLAArgGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 148 AVGYPFVGYLVVGHNWETSFHVLGLINVLlgVPLVWAFVRMPkvetgmpkpqsmgeavgqvgqivrgamhtryLWLITIl 227
Cdd:cd17318 161 VIAMPLSGFLCESLGWPSIFYIFGGLGLL--WCLLWFFLVLP-------------------------------VWAIVV- 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 228 taAFLSYLWGSS---NWLPAYLKESRGFSMREMGWLASLPQYASVAAVFVGGMIIDRIARRQV-PLIFV------FGSLG 297
Cdd:cd17318 207 --AHFGHNWGFYtllTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGIlSTTTVrklftsIGFLG 284
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 692357228 298 VAIAVWLAIHM-EDRYAAAYCLIAANFCWGLMSPAIPSTVQHCArPEHVASAYGVVNGAGSLVAGFMPAIMGAVI 371
Cdd:cd17318 285 PGVFLIALGYLgSNATLAVVFLTLSVGLSGACYSGFLVNHLDLA-PNYAGTLMGITNTAATIAGIISPLIVGAIV 358
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
47-399 |
2.67e-14 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 73.79 E-value: 2.67e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 47 GLLATAFMVGYGVSSFVLTPFcAALFGVRRSLFAGLLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKAH 126
Cdd:cd17316 39 GLLFAAGFLGRPIGALLFGYL-GDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEF 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 127 FESRENGKPNSLVNMGTGLGLAVGYpFVGYLVVGHNWET----SFHVLGLINVLLGVPLVwafvrmpkvetgmpkpqsmg 202
Cdd:cd17316 118 APSKRRGFALGLLQSGWALGALLAA-LVASLLIPLLSGDwgwrILFLIGALPALLALLLR-------------------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 203 eavgqvgqivrgamhtRYLWLITILTAAFLSYLWGSSNWLPAYLKESRGFSMREMGWLASLPQYASVAAVFVGGMIIDRI 282
Cdd:cd17316 177 ----------------RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 283 ARRQVPLIFVFGSLGVAIAVWLAIHMEDrYAAAYCLIAANFCWGLMSPAIPSTVQHCARPEHVASAYGVVNGAGSLVAGF 362
Cdd:cd17316 241 GRKKTLVIGLILSGILALPLFYLLSGSP-TLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGG 319
|
330 340 350
....*....|....*....|....*....|....*..
gi 692357228 363 MPAIMGAvigALSARGGVSAGFFAGFAALIGTQVIVM 399
Cdd:cd17316 320 APPLIAL---LLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
51-403 |
2.00e-13 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 71.07 E-value: 2.00e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 51 TAFMVGYGVSSFVLTPFcAALFGVRRSLFAGLLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKAHFESR 130
Cdd:cd17320 41 SAYLLGFALGQLLYGPL-SDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGA 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 131 ENGKPNSLVNMGTGLGLAVGYPFVGYLVVGHNWETSFHVLGLINVLLgvpLVWAFVRMPKVETGMPKPQSMGEAVGQVGQ 210
Cdd:cd17320 120 ELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLL---LLLVLLFLPETLPEEKRKPLLSSLLRAYKR 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 211 IVRGAMHTRYLWLITILTAAFLSYLWGSSNWLPAYLkesrGFSMREMGWLASLPqyasVAAVFVGGMIIDRIARR--QVP 288
Cdd:cd17320 197 VLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQL----GLSPAQFGLLFALN----AIALILGSLLNGRLVRRfgPRR 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 289 LIFVFGSLGVAIAVWLAIHMEDRYAAAYCLIAANFCWGLMSPAIPSTVQHCArpehvASAYGVVNGAGSLVAGFMPAIMG 368
Cdd:cd17320 269 LLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLA-----LEPFPHVAGTASALLGFLQFLIG 343
|
330 340 350
....*....|....*....|....*....|....*.
gi 692357228 369 AVIGALSAR-GGVSAGFFAGFAALIGTQVIVMLCGI 403
Cdd:cd17320 344 ALAGALVGLlPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
47-368 |
2.68e-13 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 70.81 E-value: 2.68e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 47 GLLATAFMVGYGVSSFvLTPFCAALFGVRRSLFAGLLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKAH 126
Cdd:cd17333 34 SVIFSSQNAGYLIGSL-LAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGAL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 127 FESRENGKpNSLVNMGTGLGLAVGYPFVGYLV-VGHNWETSFHVLGLINVLLgvPLVWAFVRMPKVEtgmpkpqSMGEAV 205
Cdd:cd17333 113 FEESSATR-LNVLHGFFGLGALIGPLIATSLLtSELSWSWAYLIIGLIYLLL--AILILLTLFPELP-------SARNPQ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 206 GQVGQIVRGAMhtRYLWLITILTAAFLSYLWGS-----SNWLPAYLKESRGFSMREMGWLASLPQYASVAAVFVGGMIID 280
Cdd:cd17333 183 QSVGAFSASAS--RLLRNPSIILGALALFLYVGaetafSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISR 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 281 RIArrqvPLIFVFGSLGVAIAVWLAIHMEDRYAAaycLIAANFCWGL-MSPAIPSTVQHCAR--PEHVASAYGVVNGAGS 357
Cdd:cd17333 261 RIK----PHTLLVLSGSGALLGLLILLLAPTLVV---GLVATALLGLfMAALFPTILSLGISnlPYAKGKGTSVLLAAGS 333
|
330
....*....|.
gi 692357228 358 LVAGFMPAIMG 368
Cdd:cd17333 334 IGGAIIPFIMG 344
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
47-375 |
4.03e-13 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 70.34 E-value: 4.03e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 47 GLLATAFMVGYGVSSFVlTPFCAALFGVRRSLFAGLLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKAH 126
Cdd:cd17475 34 GLLLSALNLGVAVSMLP-AGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRW 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 127 FESRENGKPNSLVNMGTGLGLAVGYPFVGYLVVGHNWETSFHVLGLINVLLGVpLVWAFVRMPkvetgmPKPQSMGEAVG 206
Cdd:cd17475 113 FPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAV-LFWLFYREP------PAASAATESAS 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 207 QVGQIVRGAMHTRYLWLITILTAAFLSYLWGSSNWLPAYLKESRGFSMREMGWLASLPQYASVAAVFVGGMIIDRIA--R 284
Cdd:cd17475 186 TLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFggR 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 285 RQVPLIFV--FGSLGVAIAVWLAIHMEDRYAAAYCLIAANFCWGLMSPAIpSTVQHCARPEHVASAYGVVNGAGSLVAGF 362
Cdd:cd17475 266 RRPVLVITaaIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYL-TLVAESAGPEQAGTALGLANTINFIGIAI 344
|
330
....*....|...
gi 692357228 363 MPAIMGAVIGALS 375
Cdd:cd17475 345 GPPLFGLLVDATH 357
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
2-406 |
1.37e-12 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 68.45 E-value: 1.37e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 2 RWWGVVTLFVIVAISYVDRINISVLITDhdFLSHIGLTPDDrtrQGLLATAFMVGYGVSSFVlTPFCAALFGVRRSLFAG 81
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPP--IVEEIGLSKDD---LGIIGSAFLIAYAVGKFI-SGFLSDRSNIRRFMSAG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 82 LLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKAHFESRENGKPNSLVNMGTGLGLAVGYPFVGYLVVGH 161
Cdd:cd17312 75 LLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 162 NWETSFHVLGLInVLLGVPLVWAFVRmpkvetgmpkpqsmgeavgqvgqivrgaMHTRYLWLITIltAAFLSYL--WGSS 239
Cdd:cd17312 155 GWRAAFLVPGIV-GLVVAIILFFFLR----------------------------DSPPYVWVLSL--AYAFVYIvrYACL 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 240 NWLPAYLKESRGFSMREMGWLASLPQYASVAAVFVGGMIIDRI--ARRQVP-LIFVFGSLGVAIAVWLAIHmeDRYAAAY 316
Cdd:cd17312 204 DWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLfgGRRAPIaVIYMLLMTLSLALFWFFPH--NKLLSIV 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 317 CLI--------AANFCWGLMSPAIPstvqhcaRPEHVASAYGVVNGAGSLVAGFMPAIMGAVIgalsarggVSAGFFAGF 388
Cdd:cd17312 282 LLFligffvggPINLIGGAAAQDIG-------RKEAAGTATGFVGLFGYLGASLAGLPLGYII--------DHYGWSTVF 346
|
410
....*....|....*...
gi 692357228 389 AALIGTQVIVMLCGIVLW 406
Cdd:cd17312 347 YFLISAALLSVLLLLSLW 364
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
42-392 |
2.89e-12 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 67.68 E-value: 2.89e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 42 DRTRQGLLATAFMVGYGVSSfvltPFCAAL---FGVRRSLFAGLLLWGVVTFLSPAMNSY-GLLLASRILLGVSEGPLFS 117
Cdd:cd17355 36 SRAVISLAFTVGLLAFGLAQ----PFVGRLldrFGPRRVMLLGLLLLAAGLVLLALATSLwQLYLLWGLLGGGGAGTLAA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 118 LAGSYIKAHFESRENGKPNSLVNMGTGLGLAVGYPFVGYLVVGHNWETSFHVLGLINVLLGVPLVWAFVRMPKVETGMPK 197
Cdd:cd17355 112 VAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAY 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 198 PQSMGEAVGQVgqiVRGAMHTRYLWLITILTAAFLSYLWGSSNWLPAYLKEsRGFSMREMGWLASLPQYASVAAVFVGGM 277
Cdd:cd17355 192 DDASPASPGST---LKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLAD-RGISPAAAAVALALIGLFNIVGRLLSGW 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 278 IIDRIARRqVPLIFVFGSLGVAIAVWLAIHMEDRYAAAYCLIAAnFCWGLMSPAIPSTVQHCARPEHVASAYGVVNGAGS 357
Cdd:cd17355 268 LGDRYSPR-RLLAASYALRALGLALLLLLPFPPLALLLFAALFG-LGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQ 345
|
330 340 350
....*....|....*....|....*....|....*..
gi 692357228 358 LVAGFMPAIMGAVIGALSARGGV--SAGFFAGFAALI 392
Cdd:cd17355 346 LGSALGPWLGGLLYDRTGSYTAAwaLAVALGLIAALL 382
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
72-400 |
5.76e-12 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 66.83 E-value: 5.76e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 72 FGVRRSLFAGLLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKAHFESRENGKPNSLVNMGTGLGLAVGY 151
Cdd:cd17473 62 FGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFL 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 152 PFVGYLvVGHNWETSFHVLGLINVLLgvPLVWAFVrmpkvetgmPKPQSMGEAVGQVGQIVRGAMHTRYLWLITILTAAF 231
Cdd:cd17473 142 LLGGAL-AEIGWRAPFLVYLLALPVL--ILVLLFL---------PEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLA 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 232 LSYLWGSSNWLPAYLKESRGFSMREMGWLASLPQyasvAAVFVGGMIIDRIARR-QVPLIFVFGSLGVAIAVWLAIHMED 310
Cdd:cd17473 210 MLLFYVIPIQLPFLLQERGGGSAALIGLALAIAS----LAGAIGALLFGRLKRRlGKRRLLAIGFALMALGFLLLALASG 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 311 RYAAAYCLIAANFCWGLMSPAIPSTVQHCARPEHVASAYGVVNGAGSLVAGFMPAIMGAVIgalSARGGVSAGFFAGFAA 390
Cdd:cd17473 286 LWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLV---NLTGGLSGAFLILGVL 362
|
330
....*....|
gi 692357228 391 LIGTQVIVML 400
Cdd:cd17473 363 ALVLAIVLLL 372
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
47-401 |
3.27e-11 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 64.51 E-value: 3.27e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 47 GLLATAFMVGYGVSSFVLTPFcAALFGVRRSLFAGLLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKAH 126
Cdd:cd17474 37 GLLITAFTLPAAVLMPVAGVL-ADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 127 FESRENGKPNSLVNMGTGLGLAVgYPFVGYLVVGHNWETSFHVLGLINVLLGVPLVWafvrmpkvetgMPKPQSMGEAVG 206
Cdd:cd17474 116 FEGGERAKAMGLYEAALGLGIAV-GPLLGGLLAAISWRYPFFLLAALIPVAFLAILF-----------LLPEPKEKAKSS 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 207 QVGQIVRGAMHTRYLWLITILTAAFLSY--LWGSSNWLPAYLKESRGFSMREMGWLASLPQYASVAAVFVGGMIIDRIAR 284
Cdd:cd17474 184 SATKLRDLKKALRGRGLLTFLVSAFLYFflYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 285 RQVPLIFVFGSLGVAIAVWLAIHmeDRYAAAYCLIAANFCWGLMSPAIPSTVQHCARPEHVASAYGVVNGAGSLVAGFMP 364
Cdd:cd17474 264 ARRILVIGLLLYALSLLLLGFVP--SLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGP 341
|
330 340 350
....*....|....*....|....*....|....*..
gi 692357228 365 AIMgaviGALSARGGVSAGFFAGFAALIGTQVIVMLC 401
Cdd:cd17474 342 LLF----GLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
44-393 |
1.53e-10 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 62.19 E-value: 1.53e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 44 TRQGLLATAfmvgYGVSSFVLTPFCAAL---FGVRRSLFAGLLLWGVVTFLSPAMNSYGLLLASRILLGVSEGpLFSLAG 120
Cdd:cd17478 31 AQAGLLVSV----FSITSSLLQPLFGYLadrKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSA-AFHPEG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 121 SYIKAHFESRENGKPNSLVNMGTGLGLAVGyPFVGYLVVGHNWETSFHVLGLINVLLGVPLVWAFVRMPKVEtgmPKPQS 200
Cdd:cd17478 106 ARLASQAAGGRRGLAMSIFSVGGNLGFALG-PLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPE---AKKAA 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 201 MGEAVGQVGQIVRGAmhtryLWLITILTAAFLSYLWGSSNWLPAYLKEsRGFSMREMGWLASLPQYASVAAVFVGGMIID 280
Cdd:cd17478 182 AKSSARSTLKGVWRA-----LLLLLIIVFLRSWVLSSLTTFLPFYLVQ-RGYSLVFAGLLLSLFLFAGAIGTLIGGPLSD 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 281 RIARRQVpliFVFGSLGVAIAVWLAIHMEDRYAAAYcLIAANFCWGLMSPAIPSTVQHcARPEHVASAYGVVNGagslVA 360
Cdd:cd17478 256 RFGRRRV---IIASLLLAAPFLLLFLLTPGIWSYIL-LVLAGFLLFASFPVTVVLAQE-LLPGNVGLASGLMMG----LS 326
|
330 340 350
....*....|....*....|....*....|....
gi 692357228 361 GFMPAIMGAVIGALSARGGVSAGF-FAGFAALIG 393
Cdd:cd17478 327 FGLGGIGAPVLGALADAFGLESVLlILALLPLLG 360
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
46-295 |
2.22e-10 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 61.37 E-value: 2.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 46 QGLLATAFMVGYGVSSFVLTPFcAALFGVRRSLFAGLLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKA 125
Cdd:COG0477 51 LGWIVSAYLLGRAIGLLLFGRL-GDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAE 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 126 HFESRENGKPNSLVNMGTGLGLAVGYPFVGYLVVGHNWETSFhvlgLINVLLGVPLVWAFVRMPKVETGMPKPQSMGEAV 205
Cdd:COG0477 130 LFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF----LINAPLGLLALVLRLRLPESRGLLLALLALALAA 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 206 GQVGQIVRGAMHTRYLWLITILTAAFLSYLWGSSNWLPAYLKESRGFSMREMGWLASLPQYASVAAVFVGGMIIDRIARR 285
Cdd:COG0477 206 LLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLL 285
|
250
....*....|
gi 692357228 286 QVPLIFVFGS 295
Cdd:COG0477 286 LLLLLLALLL 295
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
47-404 |
2.21e-09 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 58.74 E-value: 2.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 47 GLLATAFMVGYGVSSfVLTPFCAALFGVRRSLFAGLLLWGVVTFLSPAMNSYGLLLASrILLGVSEGPLFSLAGSYIKAH 126
Cdd:cd17339 37 GLLTTLPLLCFAVFS-PLAPRLARRFGLERTLLLALLLLAAGILLRSLGGIALLFLGT-ALAGAGIAVGNVLLPSLIKRD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 127 FESRE---NGKPNSLVNMGTGLGLAVGYPFVGYLVVGhnWETS---FHVLGLINVLLGVPLVWAFVRMPKVETGMPKpqs 200
Cdd:cd17339 115 FPRRVglmTGLYTTSMNLGAALASGLSVPLAQALGGG--WRGAlaiWALPALLALLIWLPQLRRRKRAAAAAAPLTK--- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 201 mgeavgqvgqivRGAMHTRYLWLITIL--TAAFLSYLWgsSNWLPAYLKEsRGFSMREMGWLASLPQYASVAAVFVGGMI 278
Cdd:cd17339 190 ------------ISVWRSPLAWQVTLFmgLQSLLFYTL--MAWLPTILID-AGLSAATAGWLLSLFQLVGIPASLLVPIL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 279 IDRiARRQVPLIFVFGSLGVA--IAVWLAIHMEDRYAAAYCLIAANFCWGLmspAIPSTVQHCARPEHVASAYGVVNGAG 356
Cdd:cd17339 255 ATR-LKNQRPIVVLLAVLFIIgvLGLLFAPTALALLWAVLLGLGGGAAFSL---ALTLISLRSSDPAEAAALSGMAQSVG 330
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 692357228 357 SLVAGFMPAIMGAVIGAlsarggvSAGFFAGFAALIGTQVIVMLCGIV 404
Cdd:cd17339 331 YLLAALGPLLFGVLHDL-------TGSWTAPLVLLLALTVLQLVAGLG 371
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
2-406 |
3.54e-09 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 58.41 E-value: 3.54e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 2 RWWGVVTLFVIVAISYVDRINISVLItdHDFLSHIGLTpddRTRQGLLATAFMVGYGVSSFVLtpfcaALFGVRRS---- 77
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQ--PYLIEQYGLS---KTEIGLIGSALSIAYGLSKFVM-----GNLSDRSNpkrf 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 78 LFAGLLLWGVVT----FLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKAHFESRENGKP----NSLVNMGTGL-GLA 148
Cdd:cd17345 71 LAIGLILSAIINiligFVPSATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWtsiwNISHNVGGGLvGPL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 149 VGypFVGYLVVGHNWETSFHVLGLINVLLGVpLVWAFVR-------MPKVET--GMPKPQSMGEAVGQ---VGQI-VRGA 215
Cdd:cd17345 151 AG--LGLAIFGDGWWRGAFIFPAIIAIIVAV-IVLFLGKdtpesegLPPIEEykGDYPEEADGEEEEQelsAWEIfVKYV 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 216 MHTRYLWLITILTAAFLSYLWGSSNWLPAYLKESRGFSMREMGWLASLPQYASVAAVFVGGMIIDRIARRQVPLIFVFGS 295
Cdd:cd17345 228 LKNKLLWYIAIANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKGRRAPTGIIFM 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 296 LGVAIAVWLAIHMEDRYAAAYCLIAANFCwgLMSPAIPSTVQhcarpehvasAYGVV--NGAGSlVAGFMpAIMGAVIGA 373
Cdd:cd17345 308 ILVIVALIVYWLAPNVLVDLIALIALGFL--IYGPVMLIGLQ----------ALELVpkKAAGT-AAGLT-GLFGYLGGS 373
|
410 420 430
....*....|....*....|....*....|....*...
gi 692357228 374 LSARGGVSA-----GFFAGFAALIGTQVIVMLCGIVLW 406
Cdd:cd17345 374 VLATALIGIivdhfGWNGGFIVLLASCILAIIFLALVA 411
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
54-391 |
3.99e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 57.95 E-value: 3.99e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 54 MVGYGVSSFVLTPFCAAL---FGVRRSLFAGLLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKAHFESR 130
Cdd:cd17321 37 VNAYLLAFAALLLLAGRLgdrFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 131 ENGKPNSLVNMGTGLGLAVGYPFVGYLVVGHNWETSFhvlgLINVLLGVpLVWAFVRMpkvetgmpkpqsmgeavgqvgq 210
Cdd:cd17321 117 RRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIF----LINVPIGL-VALLLART---------------------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 211 ivrgamhtrylWLITILTAAFLSYLWGSSN-WLPAYLKESRGFSmremGWLASLPQYASVAAVFVGGMIIDRIARRQVPL 289
Cdd:cd17321 170 -----------FSGAVLAAFLLGAALGGLLfLLPLYLQGVLGYS----PLQAGLALLPLALAMLVAAPLAGRLADRFGPR 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 290 IFVFGSLGVAIA--VWLAIHMEDRYAAAYC--LIAANFCWGLMSPAIPSTVQHCARPEHVASAYGVVNGAGSLVAGFMPA 365
Cdd:cd17321 235 LVLVAGLLLTAVglLLLALLGADSSVWLLLpgLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVA 314
|
330 340
....*....|....*....|....*.
gi 692357228 366 IMGAVIGALSARGGVSAGFFAGFAAL 391
Cdd:cd17321 315 LLGALLTAGLSANLGDSGVAALLSAA 340
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
46-400 |
4.94e-09 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 57.70 E-value: 4.94e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 46 QGLLATAFMVGYGVSSfVLTPFCAALFGVRRSLFAGLLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKA 125
Cdd:cd17371 36 AGLLGTVTLAGGAIGG-ILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAE 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 126 HFESRENGKPNSLVNMG--TGLGLAVG--YPFVGYLVVGHNWETSFhVLGLINVLLgVPLVWAFVRMPKVETGMPKPQSM 201
Cdd:cd17371 115 YVPARHRGKALGYVQSGwaVGWLLATLlaALLFPLLPPEIAWRVLF-LLGALPALL-VLFIRRFVKEPPQWQAARAARRH 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 202 GEAVGQVGQIVRGAMhtRYLWLITILTAAFLSY-LWGSSNWLPAYLKESRGFSMREMGWLASLPQYASVAAVFVGGMIID 280
Cdd:cd17371 193 FADRPSLRELFSPPL--LRTTLLASLLATGALGgYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLAD 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 281 RIARRqvpLIFVFGSLGVAIAVWLAIHMEDRYAA-AYCLIAANFCWG--------LMSPAIPSTVQhcarpehvASAYGV 351
Cdd:cd17371 271 RIGRR---NNFALFALGSAISILLYFFLPLSPTLiLILGFPLGFFASgpfsgmgaYLTELFPTAVR--------ATAQGF 339
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 692357228 352 VNGAGSLVAGFMPaimgAVIGALSARGGVSAGFFAGFAALIGTQVIVML 400
Cdd:cd17371 340 CYNVGRIIGALFP----FLVGFLATSGSLGTAIAVFAAVYYIAGLVLAL 384
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
1-317 |
5.24e-09 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 57.64 E-value: 5.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 1 MRWWGVVTLFVIVAISYVDRINISV-----LITDhdflshIGLTPDDRTrqgLLATAFMVGYGVSSFVLTPFCAAlFGVR 75
Cdd:cd17327 2 LDLFILPLLCILYFLQYLDKSNISNaavmgMKED------LKLVGNQYN---WGNTVFYVGYIIFELPGNLLLQR-FPPS 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 76 RSLFAGLLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKAHFESRENGKPNSLVNMGTGLGLAVG----Y 151
Cdd:cd17327 72 KWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGgllaY 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 152 PFVGYLVVG--HNWETSFHVLGLINVLLGVPLVWAFVRMPKVETGMPK-------------PQSMGEAVGQVGQIvRGAM 216
Cdd:cd17327 152 GVFKILGVGglAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEeekelaverlranQTGKGDQKFKWKQI-KEAF 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 217 HTRYLWLITILTAAFLSYLWGSSNWLPAYLKeSRGFSMREMGWLASLPQYASVAAVFVGGMIIDRIARRQVPLIF--VFG 294
Cdd:cd17327 231 KDPRTWLLFLFFFCSQITNNGISNFLPLILK-SLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFacVLA 309
|
330 340
....*....|....*....|...
gi 692357228 295 SLGVAIAVWLAIHMEDRYAAAYC 317
Cdd:cd17327 310 LVGSIILLAAPNPPGAYFAAYIL 332
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
49-405 |
2.68e-08 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 55.27 E-value: 2.68e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 49 LATAFMVGYGVSsFVLTPFCAALFGVRRSLFAGLLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKAHFE 128
Cdd:cd17503 36 VITSYLLALAIM-IPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYP 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 129 SRENGKPNSLVNMGTGLGLAVGYPFVGYLVVGHNWETSFhvlgLINVLLGvplVWAFVRMPKVETGMPKpqsmgeavgqv 208
Cdd:cd17503 115 PEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIF----YINLPIG---ILALLLAPLLDLRLFK----------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 209 gqivrgamhTRYLWLITILTAAFLSYLWGSSNWLPAYLKESRGFSMREMGWLASLPQYASVAAVFVGGMIIDRIARRqvp 288
Cdd:cd17503 177 ---------DRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPR--- 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 289 LIFVFGSLGVAIAVWLAIHMEDRYAAAYcLIAANFCWGL-----MSPAIPSTVQhCARPEHVASAYGVVNG----AGSLV 359
Cdd:cd17503 245 LLLLAGLLLLALGTLLLAFLTPDTSLWL-IILPLFIRGLgmglvFMPLNTLALN-SLPPEQIGDATALFNTirqlGGSIG 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 692357228 360 AGFMPAIM-------GAVIGALSARGGVSAGFFAGFAALIGTQVIVMLCGIVL 405
Cdd:cd17503 323 TALLATLLtnrtqfhHSRLSELLAQQVQKQALIIAFNDAFLVSAILLLVGLLL 375
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
47-392 |
7.42e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 53.72 E-value: 7.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 47 GLLATAFMVGYGVSSFVLTPFCAAlFGVRRSLFAGLLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKAH 126
Cdd:cd17477 34 GLVASAYYLGILLGSPLVPRLIRR-VGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNAL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 127 FESRENGKPNSLVNMGTGLGLAVGYPFVGylVVGHNWETSFHVLGLINVLLGVPLVWafvrMPKVETGMPKPQSMGeaVG 206
Cdd:cd17477 113 ATNENRGRVLGLYSTVLGLGFALGPLLLA--LVGTAGALPFLIAAVLLLLALVPLLL----TRRAAPEIEEAESIS--LR 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 207 QVGQIVRGAMhtrylwLITILTAAFLSYLWGSsnwLPAYLKESrGFSMREMGWLASLPQYASVAAVFVGGMIIDRIARRQ 286
Cdd:cd17477 185 RLLRIAPLAL------LGAFVAGFLEGAFYSL---LPLYGLRL-GLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRR 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 287 VPLIFVFGSLGVAIAVWLAIHMedryaaAYCLIAANFCWGLMSPAIPS-----TVQHCARPEHVA--SAYGVVNGAGSLV 359
Cdd:cd17477 255 VLLGCALLGALAALLLPLVPGL------PLALLVLLFLWGGAAGPLYTlalalAGDRLPGDELVAanAALLLLYGLGSVI 328
|
330 340 350
....*....|....*....|....*....|....*
gi 692357228 360 AgfmPAIMGAVIGALSARG--GVSAGFFAGFAALI 392
Cdd:cd17477 329 G---PLLAGALMDAFGPHGlfLFLAAVALLFLLFL 360
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
42-371 |
1.58e-07 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 53.13 E-value: 1.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 42 DRTRQGLLATAFMVGYGVSSFVLTPFCAAlFGVRRSLFAGLLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFSLAGS 121
Cdd:TIGR00895 50 DPVQLGFLFSAGLIGMAFGALFFGPLADR-IGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNA 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 122 YIKAHFESRENGKPNSLVNMGTGLGLAVGYPFVGYLVVGHNWETSFHVLGLINVLLgVPLVWAFV--------------- 186
Cdd:TIGR00895 129 LVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLL-LLLLMRFLpesidflvskrpetv 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 187 -----------RMPKVETGMPKPQSMGEAVGQVGQIVRGAM--HTRYLWLITILTaafLSYLWGSSNWLPAYLKESrGFS 253
Cdd:TIGR00895 208 rrivnaiapqmQAEAQSALPEQKSTQGTKRSVFKALFQGKTarITVLLWLLYFML---LVGVYFLTNWLPKLMVEL-GFS 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 254 MREMGWLASLPQYASVAAVFVGGMIIDRIARRQVPLIFVFGSlgvAIAVWLAIHMEDRYAAAYCLIAANFCWGLMSPAIP 333
Cdd:TIGR00895 284 LSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGA---VFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLY 360
|
330 340 350
....*....|....*....|....*....|....*...
gi 692357228 334 STVQHCARPEHVASAYGVVNGAGSLVAGFMPAIMGAVI 371
Cdd:TIGR00895 361 ALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYLL 398
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
51-372 |
2.26e-07 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 52.61 E-value: 2.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 51 TAFMVGYGVSSFVLTPFcAALFGVRRSLFAGLLLWGV-VTFLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKAHFES 129
Cdd:cd17353 45 TLTIVFLAISAPFAGRL-VDRGGPRKAILIGGILFGLgFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPD 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 130 REnGKPNSLVNMGTGLGLAVGYPFVGYLVVGHNWETSFHVLGLINVLLGVPLVWaFVRMPK--VETGMPKPQSMGEAVGQ 207
Cdd:cd17353 124 KR-GLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAF-LIRDPPkgWVPPGVDPLANNAENSP 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 208 VGQIVRGAMHTRYLWLITILTAAFLSYLWGSSNWLPAYLKESRGFSMREMGWLASLPQYASVAAVFVGGMIIDRIARRQV 287
Cdd:cd17353 202 RDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNT 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 288 pLIFVFGSLGVAIAVWLAI-HMEDRYAAAYCLIAanFCWGLMSPAIPSTVQHCARPEHVASAYGVV---NGAGSLVAGFM 363
Cdd:cd17353 282 -LSIAFLIQGVAMFLLPFIgSVAVLFVLGVALIG--FCYGGGFALFPALTADFFGTKNAGTNYGLLytaKGVGGLIGPII 358
|
....*....
gi 692357228 364 PAIMGAVIG 372
Cdd:cd17353 359 AAYVLYTGG 367
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
47-374 |
2.94e-07 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 51.92 E-value: 2.94e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 47 GLLATAFMVGYGVSSFVLtPFCAALFGVRRSLFAGLLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKAH 126
Cdd:cd06180 37 GWIATANYAGYLVGALLA-SFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHH 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 127 FESRENGKPNSLVNMGTGLGLAVGYPFVGYLVVGH-NWETSFHVLGLINVLLGVPLVWAFVRMPkvetgmpkpqsmgEAV 205
Cdd:cd06180 116 ATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGGlSWRAGWLALALLSAVLLLLSFLLLRRGP-------------SAP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 206 GQVGQIVRGAMHTRYLWLITILTAAFLSYLWGSSNWLPAYLKESRGFSMREmGWLASLPQYASVAAVFVGGMIIDRIARR 285
Cdd:cd06180 183 TEASAAESAPGLNRPLWRLALAYGLFGFGYIITATFLPLIARETGAGSLLA-GLLWSLFGLAAVPSCFLWGALSDRWGTR 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 286 Q-VPLIFVFGSLGVAIAVWLaihmedryAAAYCLIAANFCWGLMSPAIPSTVQHCARPEHVASA----------YGVVNG 354
Cdd:cd06180 262 RaLAANLLVQAVGVLLPLLS--------PGPAGLVLSAVLFGGTFMAITALVMALARELAPPAApralalmtasFGVGQI 333
|
330 340
....*....|....*....|
gi 692357228 355 AGSLVAGFMPAIMGAVIGAL 374
Cdd:cd06180 334 LGPLLAGWLADATGGFAPAL 353
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
53-393 |
3.26e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 51.84 E-value: 3.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 53 FMVGYGVSSFVLTPFCAAL---FGVRRSLFAGLLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKAHFES 129
Cdd:cd17329 40 VLALSAVAGIVASLIGGRLadrFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTP 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 130 RENGKPNSLVNMGTGLGLAVGyPFVGYLVVGHNWETSFHVLGLINVLLGVpLVWAFVRMPKVETGMPKPQSMGEAVGQVG 209
Cdd:cd17329 120 ENRTRAFSLLYWAINLGVAIG-PLLGGLLLLYSFRLLFLAAAVLFLLAAL-VLLFLLPETRPKRRAAEKTEILRGYKIVL 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 210 QivrgamHTRYLWLITILTAAFLSYLWGSSNwLPAYLKESRGFSMREMGWLASLpqyaSVAAVFVGGMIIDRIARRQVPL 289
Cdd:cd17329 198 R------DRAFLLFLLASFLISLIYFQLEST-LPVYVVEILGLGESLLGLLLAL----NALLIVLLQFPVARLVERFRLR 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 290 -IFVFGSLGVAIAVWLAIHMEDRYAAAYCLIAANFCWGLMSPAIPSTVQHCARPEHVASAYGVVNGAGSLVAGFMPAIMG 368
Cdd:cd17329 267 kILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGG 346
|
330 340
....*....|....*....|....*
gi 692357228 369 AVIGALSARGGVSAGFFAGFAALIG 393
Cdd:cd17329 347 LLLDLLGPGLPWLILAALGLIAAAL 371
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
221-392 |
6.90e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 50.88 E-value: 6.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 221 LWLITILTAAFLSYLWGSsnwLPAYLKESRGFSMREMGWLASLPQYASVAAVFVGGMIIDRIARRQVpliFVFGSLGVAI 300
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPA---LPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRV---LLIGLLLFAL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 301 AVWLAIHMEDRYAAAYCLIAANFCWGLMSPAIPSTVQHCARPEHVASAYGVVNGAGSLVAGFMPAIMGAVIGALSARGGV 380
Cdd:pfam07690 75 GLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAF 154
|
170
....*....|..
gi 692357228 381 SAGFFAGFAALI 392
Cdd:pfam07690 155 LILAILSLLAAV 166
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
42-287 |
8.83e-07 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 50.55 E-value: 8.83e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 42 DRTRQGLLATAFMVGYGVSSfVLTPFCAALFGVRRSLFAGLLLWGVVTFLSP--AMNSYGLLLASRILLGVSEGPLFSLA 119
Cdd:cd17381 63 DAETQGWILGSFFYGYIITQ-IPGGYLASKIGGKLLLGFGILGTAVFTLLTPlaADLGAGYLIAVRALEGLGEGVTFPAM 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 120 GSYIKAHFESRENGKPNSLVNMGTGLGLAVGYPFVGYLVVGHNWETSFHVLGLINVLLGVplVWAFVRMPkvetgmpkpq 199
Cdd:cd17381 142 HAMWASWAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFF--LWIWLVMP---------- 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 200 smgeavgqvgqivrgamhtryLWLITIltaAFLSYLWGSSNWL---PAYLKESRGFSMREMGWLASLPQYASVAAVFVGG 276
Cdd:cd17381 210 ---------------------LWAIVV---AHFSYNWTFYTLLtllPTYMKEILRFDIQENGFLSALPYLGCWLFMILSG 265
|
250
....*....|.
gi 692357228 277 MIIDRIARRQV 287
Cdd:cd17381 266 QIADNLREKQN 276
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
37-392 |
1.23e-06 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 50.33 E-value: 1.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 37 GLTPDDRtrqGLLATAFMVGYGVSSFVLTPFCAaLFGVRRSLFAGLLLWGV-VTFLSPAMNSYGLLLASRILLGVSeGPL 115
Cdd:cd17341 30 GLSTSQI---GLLVAIPVLAGALLRLPYGFLCD-RFGGRRVFIASLLLLLIpLLALALAVSSYWGLLVLGFLLGFA-GAN 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 116 FSLAGSYIKAHFESRENGKPNSLV----NMGTGLGLAVGYPFVG---YLVVGHNWETSFHVLGLINVLLGVpLVWAFVRM 188
Cdd:cd17341 105 FASGQPWASFWFPKEKIGGAAGGIagagNMGVAVSQLLAPLIAGaivFDGGFVGWRNAFFVPGILLAIAAV-LVLLFGDD 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 189 PkvetgmpkPQSMGEAVGQVGQIVRGAMHTRYLWLITILTAAFLSYLwGSSNWLPAYLKESRGFSMREMGWLASLPQYAS 268
Cdd:cd17341 184 L--------PTGKASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFV-GFSNVLPTYFKTRFGLPLVTAGILAALFPLAG 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 269 VAAVFVGGMIIDRIARRQVPLI-FVFGSLGVAIAVWLAIHMEDRYAAAY-CLIAANFCWGLMSPAIPSTVQHCARPEhVA 346
Cdd:cd17341 255 ALARPAGGWLSDRFGGRRRLWWlFIVMTIGAALLSLSLPTSGTNLVLFLaLFVALGLGAGAGNGSVFRMVPFIFRRE-LG 333
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 692357228 347 SAYGVVNGAGSLVAGFMPAIMGAVigalSARGGVSAGFFAGFAALI 392
Cdd:cd17341 334 AVTGLVGAIGGLGGFFLPLLFGSS----ALMTGSGVGAFSLFGVLA 375
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
72-407 |
2.80e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 49.13 E-value: 2.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 72 FGVRRS-LFAGLLLWGVV---TFLSPAMNSYGLL-------LASRILLGVSEGPLFSLAGSYIKahfESRENGKPNSLVN 140
Cdd:COG2211 77 WGRRRPwILIGAIPLALSfvlLFTAPDLSPTGKLiyalvtyLLLGLAYTLVNIPYSALGAELTP---DYEERTRLSSWRF 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 141 MGTGLGLAVGYPFVGYLV--VGHNWETSFHVLGLINVLLGVPLVWAFVRmpkvetGMPKPQSMGEAVGQVGQIVRGAMHT 218
Cdd:COG2211 154 AFAGLGGLLASVLPPPLVaaFGGDAALGYRLTALIFAVLGLLAFLLTFF------GTKERPVPEEEKVSLKESLKALLKN 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 219 RYLWLITILTAAFLSYLWGSSNWLPAYLKESRGFSMREMGWLASLPQYASVAAVFVGGMIIDRIARRQVpLIFVFGSLGV 298
Cdd:COG2211 228 RPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKA-FIIGLLLAAL 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 299 AIAVWLAIHMEDRYAAAYCLIAANFCWGLMSPAIPSTVQHCARPEHVAS---AYGVVNGAGSLVAGFMPAIMGAVIGALS 375
Cdd:COG2211 307 GLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTgrrREGLYFGIFTFAIKLGQALAGALAGLLL 386
|
330 340 350
....*....|....*....|....*....|..
gi 692357228 376 ARGGVSAGFFAGFAALIGTQVIVMLCGIVLWV 407
Cdd:COG2211 387 ALFGYVAGAAQSPSALTGIRLLFFLLPAVLLL 418
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
48-285 |
3.90e-06 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 48.73 E-value: 3.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 48 LLATAFMVGYGVSSFVLTPFcAALFGVRRSLFAGLLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKAHF 127
Cdd:cd17323 38 LGVSLFVLGFGLGPLIWAPL-SELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLF 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 128 ESRENGKPNSLVNMGTGLGLAVGYPFVGYLVVGHNWETSFHVLGLINvllGVPLVWAFVRMPKVetgmpkpqsmgeavgq 207
Cdd:cd17323 117 TPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIIS---GFCLILIFLFLPIV---------------- 177
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 692357228 208 vgqivrgamhtrylWLITILTAAFLSYLWGSSNWLPAYLKESRGFSMREMGwLASLPQ-YASVAAVFVGGMIIDRIARR 285
Cdd:cd17323 178 --------------LLLGLYVGLVYAILYLFLTAFPYVFGEVYGFSPGEVG-LMYLPIgIGALIGSIIGGRLSDYYYRR 241
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
42-400 |
4.85e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 48.38 E-value: 4.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 42 DRTRQGLLATAFMVGYGVSSFVLTPFCAAL---FGVRRSLFAGLLLWGVVTFLSPAMNSYG-----LLLASRILLGVSEG 113
Cdd:cd06173 28 QLTGSALLVGLVLAAFFLPFLLFSPFAGVLadrFDRRRLLILADLLRALLAAVLALLALLGslslwLLLVLAFLLGIASA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 114 PLFSLAGSYIKAHFESRENGKPNSLVNMGTGLGLAVGYPFVGYLVVGHNWETSFhvlgLINVLLGVPLVWA--FVRMPKV 191
Cdd:cd06173 108 FFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAF----AINALSFLLSALLllFIRRPPP 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 192 ETGMPKPQSMGEAVGQVGQIVRGAMHTRYLWLITILTAAFLSYLWGSsnwLPAYLKESRGFSMREMGWLASLpqyASVAA 271
Cdd:cd06173 184 AAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVL---LPLLAKEVLGGGAAGYGLLLAA---FGVGA 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 272 VfVGGMIIDRIARRQVP-LIFVFGSLGVAIAVWLAIHMEDRYAAAYCLIAANFCWGLMSPAIPSTVQHCARPEHVasayG 350
Cdd:cd06173 258 L-LGALLLGRLSKRRRRgRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELR----G 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 692357228 351 VVNGAGSLVAGFMPAIMGAVIGALSARGGVSAGFFAGFAALIGTQVIVML 400
Cdd:cd06173 333 RVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
47-378 |
5.61e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 47.97 E-value: 5.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 47 GLLATAFMVGyGVSSFVLTPFCAALFGVRRSLFAGLLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKAH 126
Cdd:cd17489 34 GLVVGLFTLA-ALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 127 FESRENGKPNSLVNMGTGLGLAVGyPFVGYLVVGHNwetSFHVLGLINVLLGVpLVWAFVRMPKVETGMPKPQSMGEAVG 206
Cdd:cd17489 113 IPPSRRGEGIGYYGLATTLAMALG-PALGLFLYQHL---GFAVLFIVAAVLAL-LALLLVFLVKDPPPVAAEEAEAGTRA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 207 QVGQIVRGAM-HTRYLWLITILTAAFLSYlwgssnwLPAYLKEsRGFSMreMGWLASLPQYASVAAVFVGGMIIDRIARR 285
Cdd:cd17489 188 FRRLVEKKVLpPALILFLASIAYGAISTF-------LPLYAAE-RGISN--AGLFFTVYAIALLLSRPFSGKLSDRKGPK 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 286 QVpLIFVFGSLGVAIAVWLAIHMedryaAAYCLIAANFC---WGLMSPAIPSTVQHCARPEHVASAYGVVNGAGSLVAGF 362
Cdd:cd17489 258 TV-IIPGLLLLALGLLLLSFAGS-----PWMLLLAAVLYglgFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGL 331
|
330
....*....|....*.
gi 692357228 363 MPAIMGAVIGALSARG 378
Cdd:cd17489 332 GGLLLGLVAELFGYRA 347
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
14-287 |
1.97e-05 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 46.56 E-value: 1.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 14 AISYVDRINISVLITD--HDFLSHIGLTPDDRTRQ--------GLLATAFMVGYGVSSfVLTPFCAALFGVRRSLFAGLL 83
Cdd:cd17382 9 CISFGIRCNLGVAIVRmvNNFTDAYGGKVIVHKAEfnwtpetvGLIESSFFWGYLVTQ-IPGGFIAAKFAANRVFGLAIF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 84 LWGVVTFLSP--AMNSYGLLLASRILLGVSEGPLFSLAGSYIKAHFESRENGKPNSLVNMGTGLGLAVGYPFVGYLVVGH 161
Cdd:cd17382 88 VTSTLNMLIPiaARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 162 NWETSFHVLGLINVLLGVplVWAFVRMPKVETgmpkpqsmgeavgQVGQIVRGamHTRYLWLITiltaaflsylwgssnw 241
Cdd:cd17382 168 GWSSPFYVYGVFGIIWYM--FWMLVSMPVYAI-------------IVANFCRS--WTFYLLLIS---------------- 214
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 692357228 242 LPAYLKESRGFSMREMGWLASLPQYASVAAVFVGGMIIDRIARRQV 287
Cdd:cd17382 215 QPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGI 260
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
90-400 |
3.41e-05 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 46.07 E-value: 3.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 90 FLSPAMNSYGLLLASRILLGVsEGPLFSLAG-SYIKAHFESRENGKPNSLVNMGTGL----GLAVGYPFVGYLVVGHNWE 164
Cdd:PRK08633 95 VLAYYLGWFWLAFAVTFLLGA-QSAIYSPAKyGIIPELVGKENLSRANGLLEAFTIVailaGTALFSFLFESVNGNTPSE 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 165 --TSFHVLGLinVLLGVPLVWAFV--RMPKVETGMPKPQSMGEAV--GQVGQIVRGAMHTRYLWLITIltaaFLSYLWGS 238
Cdd:PRK08633 174 ilGRIAPAGL--VLLAVAVLGLIFayRLPKVPAAAPEVFDKKKYLfpKLLWRNLKLLRSDRVLWLAII----GLSYFWFI 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 239 SNW----LPAYLKESRGFSMREmgwLASLPQYASVAAVFVGGMIIDRIARRQVPLIFV-FGSLGVAIAVWLAIHMEDRYA 313
Cdd:PRK08633 248 SQLaqanFPAYAKEVLGLDNTF---QVQYLLAASAIGIGIGSLLAGRLSGRHIELGLVpLGALGLALSLFLLPTAPSLAS 324
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 314 AAYCLIAANFCWGLMSPAIPSTVQHCARPehvasaygvvNGAGSLVAG-----FMPAIMGAVIGALSARGGVSAG---FF 385
Cdd:PRK08633 325 VLVLFFLFGFSAGLFIVPLNALIQFRAPE----------KELGKVLAAnnflqNVGMLLFLALTTLFSGLGLSPAglfYL 394
|
330
....*....|....*
gi 692357228 386 AGFAALIGTQVIVML 400
Cdd:PRK08633 395 IALVTLIGTLYTLLL 409
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
47-405 |
5.27e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 44.88 E-value: 5.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 47 GLLATAFMVgygvSSFVLTPFC---AALFGVRRSLFAGLLLWGVVTFLSPAMNSYGLLLASRILLGVSeGPLFSLAGSYI 123
Cdd:cd17504 34 SWVLTAYLL----VGAVSTPILgrlGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIG-GAVFPLAFALV 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 124 KAHFESRENGKPNSLVNMGTGLGLAVGYPFVGYLVVGHNWETSFHVLGLINVLLG--VPLvwafvrmpkvetgmpkpqsm 201
Cdd:cd17504 109 REEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAalVPL-------------------- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 202 geavgqvgqIVRGAMHTRYLWLITILTAAFLSYLWGSSNWLPAYLKESR----GFSMREMGWLASLPQYASVAAVFVGGM 277
Cdd:cd17504 169 ---------IDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTptgfGLGITEAGLLLLPGALVMLIAGPLAGR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 278 IIDRI-ARRQVPLIFVFGSLG-VAIAVWLAIHMEdrYAAAYCLIAANFcwGLMSPAIPSTVQHCARPEHVASAYGVVNGA 355
Cdd:cd17504 240 LIARVgPRRVLLIGLVISAVGlLLLALLHSSLWA--LVVALLLIGIGL--GLAFASLPNIVVESVPPDRTGIATGMNTVL 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 692357228 356 GSLVAGFMPAIMGAVIGALSARGGVS-----AGFFAGFAALIGTQVIVMLCGIVL 405
Cdd:cd17504 316 RTIGSAIGPAIAGAILTTYTVSITSGgvpteGAYVLAFLIGAALALAALLLSLLI 370
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
41-369 |
1.09e-04 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 43.94 E-value: 1.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 41 DDRTRQGLLATAFMVGYGVSSFVLTpFCAALFGVRR-SLFAGLLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFSLA 119
Cdd:cd17314 35 YSSSQIATAASLSNLGMLLTQPILG-FIADSFGPRPlMALAGIMVLAGYTYLSYVFNSFPLSYACFVFIGAGTGILYGSA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 120 GSYIKAHFESREnGKPNSLVNMGTGLGLAVGYPFVGYLVVGHNWETSFHVLG-LINVLLGVPLVWAFVRMPKVetgMPKP 198
Cdd:cd17314 114 VLVTTQYFPDTK-GLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGiLAAIVLSVVSLLGFKEPPDN---QARL 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 199 QSMGEAVGQVGQIVRgamhTRYLWLITIltaAFLSYLWGSsnWLPAYLKESRGfsmREMGWLAS--LPQYASVAAVFVG- 275
Cdd:cd17314 190 HVQKKKTQTMGEIFR----DKVFWILFI---AIFLVLIGG--FLFIANMASLV---RSLQLDAPsfVTKLMSIYGLFNAf 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 276 -----GMIIDRIARRQVPLIFVFGSLGVAIAVWLAIHMEDRYAAAYCLIAANFCWGLMSPAIPSTVQHCARPEHVASAYG 350
Cdd:cd17314 258 grllwGIVADFFGGRLSTLSILLTILGLGLCAFLFLLKMTPVGLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYG 337
|
330
....*....|....*....
gi 692357228 351 VVNGAGSLVAGFMPAIMGA 369
Cdd:cd17314 338 ILLFAPAIGSILGPMLGAK 356
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
37-325 |
1.13e-04 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 43.83 E-value: 1.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 37 GLTPDDRtrqGLLATAFMVGYGVSSFVLTPFCAaLFGVRRSLFAGLLLWGVVTFLSP-AMNSYGLLLASRILLGVSeGPL 115
Cdd:TIGR00886 33 GLSTAQL---GNLVAVPVLAGAVLRIILGFLVD-IFGPRYTTALSLLLLAIPCLWAGlAVQSYSVLLLIRLFIGIA-GGS 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 116 FSLAGSYIKAHFESRENGKPNSLV----NMGTGL------GLAVGYPFVGYLVVGHNWETSFHVLglINVLLGVPLVWAF 185
Cdd:TIGR00886 108 FASCMPWISFFFPKKIQGTALGLAagwgNMGGGVaqfvmpPIIGSLIFGGGQPAHLAWGWAFVIV--PAGILLLPALLIF 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 186 VRMPKVETGMPKPQSMGeavgqVGQIVRGAMHTRYLWLITILTAAFLSYLwGSSNWLPAYLKESRGFSMREMGWLASLPQ 265
Cdd:TIGR00886 186 FVGADTPPGKPATGKLS-----FKEALKVFGNRHTWILALLYSVTFGSFL-GVSSIFAMLFKDQFGLSKVQAGAYASLGG 259
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 266 YASVAAVFVGGMIIDRIARRQVPLIFVFGSLGVAIAVWLAIHMEDRYAAAYCLIAANFCW 325
Cdd:TIGR00886 260 FLGSLARPAGGAISDRLGGARKLLMNFLGVAMGAFLVVLGLVSDGSLAAFIVLFVALFFF 319
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
245-416 |
1.17e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.14 E-value: 1.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 245 YLKESRGFSMREMGWLASLPQYASVAAVFVGGMIIDRIARRQVPLI------FVFGSLGVAIAVWLaihmedrYAAAYCL 318
Cdd:cd17329 25 YLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAglllraLGFALLGFAHSPWL-------FAIALVL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 319 IaaNFCWGLMSPAIPSTVQHCARPEHVASAYGVVNGAGSLvagfmpaimGAVIGALSARGGVSAGFFAGFAALIGTQVIV 398
Cdd:cd17329 98 T--GFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINL---------GVAIGPLLGGLLLLYSFRLLFLAAAVLFLLA 166
|
170
....*....|....*...
gi 692357228 399 MLCgIVLWVRERGEGSAA 416
Cdd:cd17329 167 ALV-LLFLLPETRPKRRA 183
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
47-184 |
4.13e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 42.22 E-value: 4.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 47 GLLATAFMVGYGVSSFVLTPFcAALFGVRRSLFAGLLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKAH 126
Cdd:cd06173 247 GLLLAAFGVGALLGALLLGRL-SKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLR 325
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 692357228 127 FESRENGKPNSLVNMGTGLGLAVGYPFVGYLVVGHNWETSFHVLGLINVLLGVPLVWA 184
Cdd:cd06173 326 VPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| PRK05122 |
PRK05122 |
major facilitator superfamily transporter; Provisional |
69-208 |
7.76e-04 |
|
major facilitator superfamily transporter; Provisional
Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 41.41 E-value: 7.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 69 AALFGVRRSLFAGLLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKAHFESRENGKPNSLVNMGTGLGLA 148
Cdd:PRK05122 83 AVVFGLCGCALSGLLYLLAGLLAAWPVLSLLLLLLGRLLLGIGESLAGTGSILWGIGRVGALHTGRVISWNGIATYGALA 162
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 149 VGYPfVGYLVVGHnweTSFHVLGLINVLLGVPLVWAFVRMPKVETGMPKPQSMGEAVGQV 208
Cdd:PRK05122 163 IGAP-LGVLLYHW---GGLAGLGLLIMLLALLGLLLARPRPAVPPVKGERLPFRRVLGRV 218
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
46-377 |
8.64e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.02 E-value: 8.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 46 QGLLATAFMVGYGVSSFVLTPFCAAL---FGVRRSLFAGLLLWGVVTFLSPAMNSYGLLLASRILLGVSEGpLFSLAGSY 122
Cdd:cd17330 32 SGYYVGLLQSSYSLGQFLASPLWGRLsdrYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGG-NVSVAQAY 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 123 IKAHFESRENGKPNSLVNMGTGLGLAVGYPFVGYLVVGHNWETSFHVLGLINvLLGVPLVWAFVrmpkvetgmpkpqsmg 202
Cdd:cd17330 111 IADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALA-LLNLVLVLFFL---------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 203 eavgqvgqivrgamhtRYLWLITILTAAFLSYLWGSSNWLPAYLKESRGFSMREMGWLASLpqyASVAAVFVGGMIIDRI 282
Cdd:cd17330 174 ----------------PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLAL---VGIAGILAQLLLIPRL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 283 ARRQVPLIFVFGSLGVAIAVWLAIHMEDRYAAAYCLIA-ANFCWGLMSPAIPSTVQHCARPEHVASAYGVVNGAGSLVAG 361
Cdd:cd17330 235 AKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAiLAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARI 314
|
330
....*....|....*.
gi 692357228 362 FMPAIMGAVIGALSAR 377
Cdd:cd17330 315 IGPLLAGPLYSFLGPG 330
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
57-186 |
9.08e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 41.02 E-value: 9.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 57 YGVSSFVLTPFCAAL---FGVRRSLFAGLLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKAHFESRENG 133
Cdd:cd17325 244 QGLASALSQPPAGKLsdrIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRG 323
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 692357228 134 KPNSLVNMGTGLGLAVGYPFVGYLVVGHNWETSFHVLGLInVLLGVPLVWAFV 186
Cdd:cd17325 324 TAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAAL-LLLAAVLFLLLR 375
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
32-345 |
1.02e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 41.13 E-value: 1.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 32 FLSHIGLTPDDRTRQGLLATA-FMVGygvssFVLTPFCAALFGV-------RRSLFAGLLLWGVVTFLSPAMNSYG---- 99
Cdd:cd17367 24 YFAPQFFPSGDPTVALLSTAAvFAVG-----FLMRPIGGWLFGRladrigrRAALTLSVSLMAAGSLVIAVTPTYAtigi 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 100 ----LLLASRILLGVSEGPLFSLAGSYIKAHFESRENGKPNSL--VNMGTGLGLAVGYPFVGYLVVGHNWETSF--HVLG 171
Cdd:cd17367 99 wapiILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFqyVTLIGGQLLALGVLLVLQHTLGEDQMAAWgwRIPF 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 172 LINVLLGVPLVWAFVRMPKVETGMPKPQSMGEAVGQVGQIVRgamHTRYLWLITILTAAFLSYLWGSSNWLPAYLKESRG 251
Cdd:cd17367 179 LLGGVLAVVVLWLRRGLEETESFEAIAESNEASAGTLRELRR---HPRELLLVVGLTAGGTLAFYTWTTYLQKFLVNTAG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 252 FSMREMGWLASLPQYASVAAVFVGGMIIDRIARRQVPLIFVFGSLGVAIAVWLAIHMEDRYAAAYCLIAANFCWGLMSPA 331
Cdd:cd17367 256 FSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALDHTDSPYTAFALVLVGLVFLSGYTS 335
|
330
....*....|....
gi 692357228 332 IPSTVQHCARPEHV 345
Cdd:cd17367 336 INAVVKAELFPTHV 349
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
42-304 |
1.17e-03 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 40.85 E-value: 1.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 42 DRTRQGLLATAFMVGYGVSSFV-------------------LTPFCAALFGVRRSLFAGLLLWGVVTFLspamNSYGLLL 102
Cdd:PRK11663 56 SRSDIGLLATLFYITYGVSKFVsgivsdrsnaryfmgigliATGIINILFGFSSSLWAFALLWVLNAFF----QGWGWPV 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 103 ASRILlgvsegplfslagsyikAHFESR-ENGKPNSLVNMGTGLGLAVGYPFVGYLVVGHNWETSFHVLGLINVLLGVPL 181
Cdd:PRK11663 132 CAKLL-----------------TAWYSRtERGGWWAIWNTAHNVGGALIPLVVGAIALHYGWRYGMMIAGIIAIVVGLFL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 182 VWafvRMPKvetgmpKPQSMG-EAVGQ-------VGQIVRGA------------MHTRYLWLITIltAAFLSYL--WGSS 239
Cdd:PRK11663 195 CW---RLRD------KPQAMGlPSVGEwrhdaleLAQQQEGAglsrkeiltkyvLLNPYIWLLSF--SYVLVYVvrAAIN 263
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 692357228 240 NWLPAYLKESRGFSMREMGWLASLPQYASVAAVFVGGMIIDRI---ARRQVPLIFVFGSLGVAIAVWL 304
Cdd:PRK11663 264 DWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDKLfngNRGPMNLIFAAGILLSVGSLWL 331
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
126-392 |
1.28e-03 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 40.67 E-value: 1.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 126 HFESRENGKPNSLVNMGTGLGLAVGYPFVGYLVVGHNWETSFHVLGLINVLLGVPLVwaFVRMPKVETGMPKPQSMGEAV 205
Cdd:cd17485 120 LLTPEERGLGNAAQVVGYKLGSLLGGGGLLWLYDLIGWQSLLLSLAALYLLLLLPVL--FLRELELPQQPPASERGAALK 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 206 GQVGQI--VRGAmhtrYLWLITILTAAFLSYlwGSSNWLPAYLKEsRGFSMREMGWLASL-PQYASVAAVFVGGMIIDRI 282
Cdd:cd17485 198 ASLRAFlrRPGT----RWLLLFLLLYKLGEQ--GALAMLPPFLVD-RGFSLSQIGLLSGVgGSLVSIAGSLLGGYLLKRR 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 283 ARRQVPLIFVFGSLGVAIAVWLAIH---MEDRYAAAYCLIAANFCWGLMSPAIPSTVQHCARPEHVASAYGVVNGAGSLV 359
Cdd:cd17485 271 GRRRLLLLGGLLRLLLLGLYTLLALggsGLNWVLLLASLALLHLVGGMITTALFTLMMDCSQQAQAGTDYTLLATVEVLG 350
|
250 260 270
....*....|....*....|....*....|...
gi 692357228 360 AGfmpaIMGAVIGALSARGGVSAgFFAGFAALI 392
Cdd:cd17485 351 KL----LFGSLAGFLADHLGYAA-AFLLFAILS 378
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
47-179 |
1.97e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 40.28 E-value: 1.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 47 GLLATAFMVGYGVSSFVLTPFCAALFGVRRSLFAGLLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKAH 126
Cdd:cd17490 233 GLLSIIYLLPNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEG 312
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 692357228 127 FESRENGKPNSLVNMGTGLGLAVGYPFVGYLVVGHNWETSFHVLGLINVLLGV 179
Cdd:cd17490 313 VPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAI 365
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
69-376 |
3.19e-03 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 39.56 E-value: 3.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 69 AALFGVRRSLFAGLLLWGVVTFLSPAMNSYGLLLASRILLGVSEGP----LFSLAGSYIkahfESRENGKPNSLVNMGTG 144
Cdd:PRK11551 74 ADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGalpnLIALTSEAV----GPRLRGTAVSLMYCGVP 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 145 LGLAVGyPFVGYLVVGH-NWETSFHVLGLINVLLgVPLVWAFV----RMPKVETGMPKPQSMGEAVGQVGQivrgAMHTR 219
Cdd:PRK11551 150 FGGALA-SVIGVLAAGDaAWRHIFYVGGVGPLLL-VPLLMRWLpesrAFAQAAGAGKQRAPVLRALFGEGR----ATATL 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 220 YLWLITILTAAFLSYLWgssNWLPAyLKESRGFSMREMGWLASLPQYASVAAVFVGGMIIDRIARRQVPLIFVFGSL--- 296
Cdd:PRK11551 224 LLWISYFFTLIVLYFLL---NWLPS-LLVGQGLSRSQAGLVQIAFNIGGALGSLLIGALMDRLRPRRVVLLIYAGILasl 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 297 -GVAIAVWLAIHMEDRYAAAYCLIAA-NFCWGLMSPAIPSTVqhcaRPEHVASAygVVNG-----AGSLVAGFMPAIMGA 369
Cdd:PRK11551 300 aALAAAPSFAGMLLAGFAAGLFVVGGqSVLYALAPLFYPTQV----RGTGVGAA--VAVGrlgsmAGPLLAGQLLALGRS 373
|
....*..
gi 692357228 370 VIGALSA 376
Cdd:PRK11551 374 TVGVIGA 380
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
32-378 |
5.00e-03 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 39.02 E-value: 5.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 32 FLSHIGLTPDDrtrqglLATAFMVgYGV----SSFvLTPFCAALFGVRRSLFAGLLLWGV--VTFLSPAM--NSYGLLLA 103
Cdd:cd17337 23 YLVDLGFSEAQ------AALLFTV-YGLtvaiASW-LSGVLAELFGPRRVMLIGLIIWLVfeVLFLAFGLpsHNYPLMLL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 104 SRILLGVSEgPLFSLAG-SYIKAHFESRengkpnslvNMGTGLGL-----AVGYPFVGYLV----VGHNWETSFHVLGLI 173
Cdd:cd17337 95 TYGLRGFGY-PLFAYSFlVWITYRTPAE---------RLGSAVGWfwfafTGGLPVLGSYLasftIPVIGEIGTLWLSLV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 174 NVLLGVPLVWAFVRMPKVETGMPKP-----QSMGEAVGQ--------VGQIVRgamhtrylwliTILTAAflsyLWGSSN 240
Cdd:cd17337 165 FVALGGLIALFLVRDRTGEQPLANPseeplKELLSGITIlfrnpkiaIGGIVR-----------IINTLS----QFGFPV 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 241 WLPAYLKESRGFSMREMGWLASLPQYASVAAVFVGGMIIDRIARRQVplIFVFGSLGVAIAV----WLAIHMEDRYAAAY 316
Cdd:cd17337 230 FMPLYFTDTGGFSTSQWLQIWGIIFLVNIFFNLIFGILGDKIGWRRT--VRWFGGVGCAISTllfyYVPQLFGHNYWAAL 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 692357228 317 cLIAANFCWGL-----MSPAIPSTVqhcarPEHVASAYGVVNGAGSLVAGFMPAIMGAVIGALSARG 378
Cdd:cd17337 308 -IAAILFGIGLagfvpLSALMPSLA-----PEHKGAAMSILNLGAGLSNFVGPAIVTLFLGSFGAGG 368
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
47-198 |
7.11e-03 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 38.51 E-value: 7.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 47 GLLATAFMVGYGVSSFVltpFCAALFG----VRRSLFAGLLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFSLAGSY 122
Cdd:pfam06779 31 GLLAAANYAGYLAGALL---ASFAWRHgasrLRPALLAGLLATVLLLLAMAATSSFWAVLLIRFLAGVASAAVMIFGSSL 107
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 692357228 123 IKAHFESRENGKPNSLVNMGTGLGLAVGYPFV-GYLVVGHNWETSFHVLGLINVLLGVPLVWAFVRMPKVETGMPKP 198
Cdd:pfam06779 108 ILGHATAARRAFVGALLFAGVGIGIALSGLLVpLGLQLGLGGSSLWYGAGVLSAVLTLAVFPLLPRRAPRHASAPAP 184
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
21-391 |
8.30e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 38.41 E-value: 8.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 21 INISVLITDHDFLSHIGLTPDDRTRQGLLATAFMVGYGVSSFVLtPFCAALFGVRRSLFAGLLLW---GVVTFLSPAMNS 97
Cdd:pfam00083 23 LTLIDFFKNFGLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFA-GKLGDRFGRKKSLLIANVLFvigAVLQGAAKGKWS 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 98 YGLLLASRILLGVSEGPLFSLAGSYIK--AHFESRenGKPNSLVNMGTGLGLAVGYpFVGYLVVGHNWETSFHVLglinv 175
Cdd:pfam00083 102 VYQLIVGRVLVGIGVGGASVLAPMYISeiAPKKLR--GALGSLYQLAITFGILLAY-IFGLGLNKTSNSDGWRIP----- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 176 lLGVPLVWA---FVRMPKV--------------------ETGMPKPQSMGEAVGQVGQIVRGAMHTRYLW---------- 222
Cdd:pfam00083 174 -LGLQLVPAlllIIGLLFLpesprwlvekgrleearevlAKLRGVPDVDRELDEIKDSLEAGQEAEKASWkelfstktrr 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 223 ---LITILTAAFLSYL-WGSSNWLPAYLKESRGFSMremGWLASLPQYA-SVAAVFVGGMIIDRIARRQvplIFVFGSLG 297
Cdd:pfam00083 253 qrlLIGVMLQIFQQLTgINAIFYYSTTIFENLGLSD---SFLVTIIVGVvNFVFTFIAIFLVDRFGRRP---LLLLGAAG 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 298 VAIAVWLAIHMEDRY-----AAAYCLIAA--------NFCWG-----LMSPAIPSTVqhcaRPEHVASAYGVVNGAGSLV 359
Cdd:pfam00083 327 MAICFVILGIVALLGvsksdWAGIVAIVFialfiaffAMGWGpvpwvIVSELFPLSV----RSKAMALATAANWLANFLI 402
|
410 420 430
....*....|....*....|....*....|..
gi 692357228 360 AGFMPAIMGAvIGalsarGGVSAGFFAGFAAL 391
Cdd:pfam00083 403 GFLFPIITDA-IG-----LGYTFFIFAGLLVL 428
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
69-208 |
9.87e-03 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 38.12 E-value: 9.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692357228 69 AALFGVRRSLFAGLLLWGVVTFLSPAMNSYGLLLASRILLGVSEGPLFSLAGSYIKAHFESRENGKPNSLVNMGTGLGLA 148
Cdd:PRK12382 83 SALQGMLACGLAGLAYLLAAILPVSAPFKFALLVVGRLILGFGESQLLTGALTWGLGLVGPKHSGKVMSWNGMAMYGALA 162
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 692357228 149 VGYPfVGYLVVGHnweTSFHVLGLINVLLGVpLVWAF-VRMPKVETGMPKPQSMGEAVGQV 208
Cdd:PRK12382 163 AGAP-LGLLLHSH---FGFAALALTTMVLPL-LAWAFnGTVRKVPAHAGERPSLWSVVGLI 218
|
|
| |
