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Conserved domains on  [gi|723185208|gb|KHC59054|]
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transcriptional activator protein UGA3 [Candida albicans P75016]

Protein Classification

Zn(II)2Cys6 transcription factor( domain architecture ID 10637823)

Zn(II)2Cys6 transcription factor domain-containing proteins form a subclass of zinc finger proteins found exclusively in fungi

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Fungal_trans_2 pfam11951
Fungal specific transcription factor domain; This family of are likely to be transcription ...
389-804 1.10e-92

Fungal specific transcription factor domain; This family of are likely to be transcription factors. This protein is found in fungi. Proteins in this family are typically between 454 to 826 amino acids in length. This protein is found associated with pfam00172.


:

Pssm-ID: 403235  Cd Length: 384  Bit Score: 295.87  E-value: 1.10e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723185208  389 YLYNYYADVLSKKISIAPisqNESNSYQKVFLPLAHRDKGVLYAILAWSGFHLGGH-----WSEEGVKYLEYALDHLNKS 463
Cdd:pfam11951   1 ELLDYYLDNVSPLLSPFP---ESSNPFRKVLLPLALSNPALLHALLALSAFHLQSSgppdlWEREAQRYKSLALRLLQRA 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723185208  464 MFDRPHH--DRQMIVNMLATLMILCAAEICKGDVKNWSVYLHWGWKLLSNNGGIL--SFNKSKEEHWLISNFAYHDLLAS 539
Cdd:pfam11951  78 LAELSSRlsSNSKYDDVLAAILLLCSFEISSGDVSDWRVHLEGAKDLIRLRGGPSktSSGLSSLLRFLLRNFAYHDILSS 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723185208  540 SSSERGTYFPSEEYDFIFRDDDGFSLGNLNPLLGISKNLYRIIGDISTLLYESKKQLDifysreftgtppgvveklnned 619
Cdd:pfam11951 158 TTTGRGPSFPSEEYLDLFGDELELGSSGLDPLMGCSNSLFLLISEISDLAREKRSLRS---------------------- 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723185208  620 adgnvdddddcesqlsdhgKASQILLSVISKVKNLEKQIDESKPAAKDLVGL---TDQELELQLTLFEAFQLSAKLFLRQ 696
Cdd:pfam11951 216 -------------------DNELLPLEFLSRAQELEQRLSSWEPRSDDLEIPldgEDPLSELLLTLTELYRLAALIYLYR 276
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723185208  697 SIMKCNPSMLESQVLNNDLIKCLDVLVGTSVQ-ASLVFPIFISGIHCVSRHDQESMRHRINKFIKlYGLWNVCRVSFVLQ 775
Cdd:pfam11951 277 RILGLPPSSPEVQELVSKLLELLDLLPDSPLAiSSLLWPLFIAGCEAVDDDDRDFVLDRLDSLEK-SRLGNVRRAREILE 355
                         410       420
                  ....*....|....*....|....*....
gi 723185208  776 KIWKDNPDGSKVVDWHNLLKELGWDINFA 804
Cdd:pfam11951 356 EVWKRRDDGELSIDWRDVMERLGWDLLLA 384
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
69-104 1.28e-10

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


:

Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 56.98  E-value: 1.28e-10
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 723185208    69 GRSRNGCLTCKVRKKKCSEEKPVCNDCSRFGKNCIY 104
Cdd:smart00066   1 KRVSKACDRCRKRKIKCDGKKPPCSNCIKLGLECTY 36
 
Name Accession Description Interval E-value
Fungal_trans_2 pfam11951
Fungal specific transcription factor domain; This family of are likely to be transcription ...
389-804 1.10e-92

Fungal specific transcription factor domain; This family of are likely to be transcription factors. This protein is found in fungi. Proteins in this family are typically between 454 to 826 amino acids in length. This protein is found associated with pfam00172.


Pssm-ID: 403235  Cd Length: 384  Bit Score: 295.87  E-value: 1.10e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723185208  389 YLYNYYADVLSKKISIAPisqNESNSYQKVFLPLAHRDKGVLYAILAWSGFHLGGH-----WSEEGVKYLEYALDHLNKS 463
Cdd:pfam11951   1 ELLDYYLDNVSPLLSPFP---ESSNPFRKVLLPLALSNPALLHALLALSAFHLQSSgppdlWEREAQRYKSLALRLLQRA 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723185208  464 MFDRPHH--DRQMIVNMLATLMILCAAEICKGDVKNWSVYLHWGWKLLSNNGGIL--SFNKSKEEHWLISNFAYHDLLAS 539
Cdd:pfam11951  78 LAELSSRlsSNSKYDDVLAAILLLCSFEISSGDVSDWRVHLEGAKDLIRLRGGPSktSSGLSSLLRFLLRNFAYHDILSS 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723185208  540 SSSERGTYFPSEEYDFIFRDDDGFSLGNLNPLLGISKNLYRIIGDISTLLYESKKQLDifysreftgtppgvveklnned 619
Cdd:pfam11951 158 TTTGRGPSFPSEEYLDLFGDELELGSSGLDPLMGCSNSLFLLISEISDLAREKRSLRS---------------------- 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723185208  620 adgnvdddddcesqlsdhgKASQILLSVISKVKNLEKQIDESKPAAKDLVGL---TDQELELQLTLFEAFQLSAKLFLRQ 696
Cdd:pfam11951 216 -------------------DNELLPLEFLSRAQELEQRLSSWEPRSDDLEIPldgEDPLSELLLTLTELYRLAALIYLYR 276
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723185208  697 SIMKCNPSMLESQVLNNDLIKCLDVLVGTSVQ-ASLVFPIFISGIHCVSRHDQESMRHRINKFIKlYGLWNVCRVSFVLQ 775
Cdd:pfam11951 277 RILGLPPSSPEVQELVSKLLELLDLLPDSPLAiSSLLWPLFIAGCEAVDDDDRDFVLDRLDSLEK-SRLGNVRRAREILE 355
                         410       420
                  ....*....|....*....|....*....
gi 723185208  776 KIWKDNPDGSKVVDWHNLLKELGWDINFA 804
Cdd:pfam11951 356 EVWKRRDDGELSIDWRDVMERLGWDLLLA 384
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
69-104 1.28e-10

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 56.98  E-value: 1.28e-10
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 723185208    69 GRSRNGCLTCKVRKKKCSEEKPVCNDCSRFGKNCIY 104
Cdd:smart00066   1 KRVSKACDRCRKRKIKCDGKKPPCSNCIKLGLECTY 36
GAL4 cd00067
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ...
70-104 1.95e-10

GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations


Pssm-ID: 238023 [Multi-domain]  Cd Length: 36  Bit Score: 56.13  E-value: 1.95e-10
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 723185208  70 RSRNGCLTCKVRKKKCSEEKPVCNDCSRFGKNCIY 104
Cdd:cd00067    1 RVRRACDRCRRRKIKCDGEKPPCSNCIKLGLECTY 35
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
74-104 9.42e-08

Fungal Zn(2)-Cys(6) binuclear cluster domain;


Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 48.83  E-value: 9.42e-08
                          10        20        30
                  ....*....|....*....|....*....|.
gi 723185208   74 GCLTCKVRKKKCSEEKPVCNDCSRFGKNCIY 104
Cdd:pfam00172   2 ACDNCRKRKVKCDGKKPACSRCIKNGLECTY 32
 
Name Accession Description Interval E-value
Fungal_trans_2 pfam11951
Fungal specific transcription factor domain; This family of are likely to be transcription ...
389-804 1.10e-92

Fungal specific transcription factor domain; This family of are likely to be transcription factors. This protein is found in fungi. Proteins in this family are typically between 454 to 826 amino acids in length. This protein is found associated with pfam00172.


Pssm-ID: 403235  Cd Length: 384  Bit Score: 295.87  E-value: 1.10e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723185208  389 YLYNYYADVLSKKISIAPisqNESNSYQKVFLPLAHRDKGVLYAILAWSGFHLGGH-----WSEEGVKYLEYALDHLNKS 463
Cdd:pfam11951   1 ELLDYYLDNVSPLLSPFP---ESSNPFRKVLLPLALSNPALLHALLALSAFHLQSSgppdlWEREAQRYKSLALRLLQRA 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723185208  464 MFDRPHH--DRQMIVNMLATLMILCAAEICKGDVKNWSVYLHWGWKLLSNNGGIL--SFNKSKEEHWLISNFAYHDLLAS 539
Cdd:pfam11951  78 LAELSSRlsSNSKYDDVLAAILLLCSFEISSGDVSDWRVHLEGAKDLIRLRGGPSktSSGLSSLLRFLLRNFAYHDILSS 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723185208  540 SSSERGTYFPSEEYDFIFRDDDGFSLGNLNPLLGISKNLYRIIGDISTLLYESKKQLDifysreftgtppgvveklnned 619
Cdd:pfam11951 158 TTTGRGPSFPSEEYLDLFGDELELGSSGLDPLMGCSNSLFLLISEISDLAREKRSLRS---------------------- 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723185208  620 adgnvdddddcesqlsdhgKASQILLSVISKVKNLEKQIDESKPAAKDLVGL---TDQELELQLTLFEAFQLSAKLFLRQ 696
Cdd:pfam11951 216 -------------------DNELLPLEFLSRAQELEQRLSSWEPRSDDLEIPldgEDPLSELLLTLTELYRLAALIYLYR 276
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723185208  697 SIMKCNPSMLESQVLNNDLIKCLDVLVGTSVQ-ASLVFPIFISGIHCVSRHDQESMRHRINKFIKlYGLWNVCRVSFVLQ 775
Cdd:pfam11951 277 RILGLPPSSPEVQELVSKLLELLDLLPDSPLAiSSLLWPLFIAGCEAVDDDDRDFVLDRLDSLEK-SRLGNVRRAREILE 355
                         410       420
                  ....*....|....*....|....*....
gi 723185208  776 KIWKDNPDGSKVVDWHNLLKELGWDINFA 804
Cdd:pfam11951 356 EVWKRRDDGELSIDWRDVMERLGWDLLLA 384
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
69-104 1.28e-10

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 56.98  E-value: 1.28e-10
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 723185208    69 GRSRNGCLTCKVRKKKCSEEKPVCNDCSRFGKNCIY 104
Cdd:smart00066   1 KRVSKACDRCRKRKIKCDGKKPPCSNCIKLGLECTY 36
GAL4 cd00067
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ...
70-104 1.95e-10

GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations


Pssm-ID: 238023 [Multi-domain]  Cd Length: 36  Bit Score: 56.13  E-value: 1.95e-10
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 723185208  70 RSRNGCLTCKVRKKKCSEEKPVCNDCSRFGKNCIY 104
Cdd:cd00067    1 RVRRACDRCRRRKIKCDGEKPPCSNCIKLGLECTY 35
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
74-104 9.42e-08

Fungal Zn(2)-Cys(6) binuclear cluster domain;


Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 48.83  E-value: 9.42e-08
                          10        20        30
                  ....*....|....*....|....*....|.
gi 723185208   74 GCLTCKVRKKKCSEEKPVCNDCSRFGKNCIY 104
Cdd:pfam00172   2 ACDNCRKRKVKCDGKKPACSRCIKNGLECTY 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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