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Conserved domains on  [gi|743326238|gb|KID32700|]
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ArsR family transcriptional regulator [Pseudoalteromonas distincta]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
10-93 1.38e-27

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 96.11  E-value: 1.38e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743326238  10 AEQAEQFLKLMANKNRLMILCSLLQGEQSVGELNKNVPLAQSALSQHLASLRKADMVATRREGHTIYYSLTDPKVESIIA 89
Cdd:COG0640    7 LEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLE 86


                 ....
gi 743326238  90 LLYE 93
Cdd:COG0640   87 WLLE 90
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
10-93 1.38e-27

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 96.11  E-value: 1.38e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743326238  10 AEQAEQFLKLMANKNRLMILCSLLQGEQSVGELNKNVPLAQSALSQHLASLRKADMVATRREGHTIYYSLTDPKVESIIA 89
Cdd:COG0640    7 LEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLE 86


                 ....
gi 743326238  90 LLYE 93
Cdd:COG0640   87 WLLE 90
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 13-88 5.33e-26

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 91.75  E-value: 5.33e-26
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 743326238  13 AEQFLKLMANKNRLMILCSLLQGEQSVGELNKNVPLAQSALSQHLASLRKADMVATRREGHTIYYSLTDPKVESII 88
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
28-91 6.00e-19

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 73.40  E-value: 6.00e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 743326238    28 ILCSLLQGEQSVGELNKNVPLAQSALSQHLASLRKADMVATRREGHTIYYSLTDPKVESIIALL 91
Cdd:smart00418   2 ILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 17-91 1.46e-18

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 73.10  E-value: 1.46e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 743326238  17 LKLMANKNRLMILCSLLQGEQSVGELNKNVPLAQSALSQHLASLRKADMVATRREGHTIYYSLTD-PKVESIIALL 91
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDaERLLALLESL 76
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 17-93 8.33e-12

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 55.88  E-value: 8.33e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 743326238  17 LKLMANKNRLMILCSLLQGEQSVGELNKNVPLAQSALSQHLASLRKADMVATRREGHTIYYSLTDPKVESIIALLYE 93
Cdd:NF033789   2 FKALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSLNTTVFEEVLGWLLD 78
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 22-66 2.02e-10

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 51.29  E-value: 2.02e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 743326238   22 NKNRLMILCSLLQGEQSVGELNKNVPLAQSALSQHLASLRKADMV 66
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 15-100 9.33e-08

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 46.35  E-value: 9.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743326238  15 QFLKLMANKNRLMILCSLLQ-GEQSVGELNKNVPLAQSALSQHLASLRKADMVATRREGHTIYYSLTdPKVESIIALLYE 93
Cdd:PRK10141   8 QLFKILSDETRLGIVLLLREsGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLS-PHIPAWAAKIIE 86


                 ....*....
gi 743326238  94 --WFCRQEN 100
Cdd:PRK10141  87 qaWLCEQED 95
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
10-93 1.38e-27

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 96.11  E-value: 1.38e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743326238  10 AEQAEQFLKLMANKNRLMILCSLLQGEQSVGELNKNVPLAQSALSQHLASLRKADMVATRREGHTIYYSLTDPKVESIIA 89
Cdd:COG0640    7 LEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLE 86


                 ....
gi 743326238  90 LLYE 93
Cdd:COG0640   87 WLLE 90
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 13-88 5.33e-26

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 91.75  E-value: 5.33e-26
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 743326238  13 AEQFLKLMANKNRLMILCSLLQGEQSVGELNKNVPLAQSALSQHLASLRKADMVATRREGHTIYYSLTDPKVESII 88
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
28-91 6.00e-19

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 73.40  E-value: 6.00e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 743326238    28 ILCSLLQGEQSVGELNKNVPLAQSALSQHLASLRKADMVATRREGHTIYYSLTDPKVESIIALL 91
Cdd:smart00418   2 ILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 17-91 1.46e-18

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 73.10  E-value: 1.46e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 743326238  17 LKLMANKNRLMILCSLLQGEQSVGELNKNVPLAQSALSQHLASLRKADMVATRREGHTIYYSLTD-PKVESIIALL 91
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDaERLLALLESL 76
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 17-93 8.33e-12

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 55.88  E-value: 8.33e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 743326238  17 LKLMANKNRLMILCSLLQGEQSVGELNKNVPLAQSALSQHLASLRKADMVATRREGHTIYYSLTDPKVESIIALLYE 93
Cdd:NF033789   2 FKALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSLNTTVFEEVLGWLLD 78
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 22-66 2.02e-10

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 51.29  E-value: 2.02e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 743326238   22 NKNRLMILCSLLQGEQSVGELNKNVPLAQSALSQHLASLRKADMV 66
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 14-72 1.83e-08

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 46.76  E-value: 1.83e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 743326238   14 EQFLKLMANKNRLMILCSLLQGE-QSVGELNKNVPLAQSALSQHLASLRKADMVATRREG 72
Cdd:pfam12840   1 DDVAEALADPTRLRILRALVGDEpLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREG 60
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 15-100 9.33e-08

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 46.35  E-value: 9.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743326238  15 QFLKLMANKNRLMILCSLLQ-GEQSVGELNKNVPLAQSALSQHLASLRKADMVATRREGHTIYYSLTdPKVESIIALLYE 93
Cdd:PRK10141   8 QLFKILSDETRLGIVLLLREsGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLS-PHIPAWAAKIIE 86


                 ....*....
gi 743326238  94 --WFCRQEN 100
Cdd:PRK10141  87 qaWLCEQED 95
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
14-94 1.35e-06

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 42.93  E-value: 1.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743326238  14 EQFLKLMANKNRLMILCSLLQGEQSVGELNKNVP-LAQSALSQHLASLRKADMVaTRREGHTI----YYSLTDP--KVES 86
Cdd:COG1733   13 RRALDVIGGKWKLLILRALLDGPRRFGELRRSLPgISQKMLTQRLRELEEDGLV-ERTVYPEVpprvEYSLTEKgrSLLP 91


                 ....*...
gi 743326238  87 IIALLYEW 94
Cdd:COG1733   92 VLDALAEW 99
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
11-82 1.93e-05

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 40.63  E-value: 1.93e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 743326238  11 EQAEQFLKLMANKNRLMILCSLLQ-GEQSVGELNKNVPLAQSALSQHLASLRKADMVATRREGHTIYYSLTDP 82
Cdd:COG3398   85 EEEKKILAYLRRETPRRILLYLLEnPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNPP 157
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 19-94 3.70e-04

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 36.13  E-value: 3.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743326238   19 LMANKNRLMILCSLLQGEQSVGELNKNVP-LAQSALSQHLASLrKADMVATRREGHT----IYYSLTD--PKVESIIALL 91
Cdd:pfam01638   1 LIGGKWKGLILRELLDGKKRFSELKRAIPgITQKMLTQRLREL-EQDGIINREVYPEvppkVEYSLTEkgRSLEPILQEL 79


                  ...
gi 743326238   92 YEW 94
Cdd:pfam01638  80 CDW 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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