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Conserved domains on  [gi|743333839|gb|KID40182|]
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calmodulin [Pseudoalteromonas distincta]

Protein Classification

EF-hand domain-containing protein( domain architecture ID 1000101)

EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FRQ1 super family cl34916
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
28-69 1.43e-04

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG5126:

Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 37.08  E-value: 1.43e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 743333839  28 LDIDGSGTISPSE-------AAVDTDLMAE-FIELDTDGSGELSKEEFAN 69
Cdd:COG5126   78 LDTDGDGKISADEfrrlltaLGVSEEEADElFARLDTDGDGKISFEEFVA 127
 
Name Accession Description Interval E-value
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
28-69 1.43e-04

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 37.08  E-value: 1.43e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 743333839  28 LDIDGSGTISPSE-------AAVDTDLMAE-FIELDTDGSGELSKEEFAN 69
Cdd:COG5126   78 LDTDGDGKISADEfrrlltaLGVSEEEADElFARLDTDGDGKISFEEFVA 127
XopAW NF041410
XopAW family type III secretion system calcium-binding effector;
28-68 1.76e-04

XopAW family type III secretion system calcium-binding effector;


Pssm-ID: 469301 [Multi-domain]  Cd Length: 227  Bit Score: 37.35  E-value: 1.76e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 743333839  28 LDIDGSGTISPSE-------AAVDTDLMAEFIELDTDGSGELSKEEFA 68
Cdd:NF041410 112 LDTDGDGSISSDElsagltsAGSSADSSQLFSALDSDGDGSVSSDELA 159
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 28-68 2.07e-04

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 35.22  E-value: 2.07e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 743333839 28 LDIDGSGTISPSEAA----------VDTDLMAEFIELDTDGSGELSKEEFA 68
Cdd:cd00051   9 FDKDGDGTISADELKaalkslgeglSEEEIDEMIREVDKDGDGKIDFEEFL 59
XopAW NF041410
XopAW family type III secretion system calcium-binding effector;
28-69 7.98e-03

XopAW family type III secretion system calcium-binding effector;


Pssm-ID: 469301 [Multi-domain]  Cd Length: 227  Bit Score: 32.73  E-value: 7.98e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 743333839  28 LDIDGSGTISPSE---AAVDT-------DLMAEFIELDTDGSGELSKEEFAN 69
Cdd:NF041410  36 LDSDGDGSVSQDElssALSSKsddgsliDLSELFSDLDSDGDGSLSSDELAA 87
 
Name Accession Description Interval E-value
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
28-69 1.43e-04

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 37.08  E-value: 1.43e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 743333839  28 LDIDGSGTISPSE-------AAVDTDLMAE-FIELDTDGSGELSKEEFAN 69
Cdd:COG5126   78 LDTDGDGKISADEfrrlltaLGVSEEEADElFARLDTDGDGKISFEEFVA 127
XopAW NF041410
XopAW family type III secretion system calcium-binding effector;
28-68 1.76e-04

XopAW family type III secretion system calcium-binding effector;


Pssm-ID: 469301 [Multi-domain]  Cd Length: 227  Bit Score: 37.35  E-value: 1.76e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 743333839  28 LDIDGSGTISPSE-------AAVDTDLMAEFIELDTDGSGELSKEEFA 68
Cdd:NF041410 112 LDTDGDGSISSDElsagltsAGSSADSSQLFSALDSDGDGSVSSDELA 159
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 28-68 2.07e-04

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 35.22  E-value: 2.07e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 743333839 28 LDIDGSGTISPSEAA----------VDTDLMAEFIELDTDGSGELSKEEFA 68
Cdd:cd00051   9 FDKDGDGTISADELKaalkslgeglSEEEIDEMIREVDKDGDGKIDFEEFL 59
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
28-70 3.85e-04

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 35.92  E-value: 3.85e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 743333839  28 LDIDGSGTISPSE--AAVDTDLMAEFIELDTDGSGELSKEEFANY 70
Cdd:COG5126   14 LDADGDGVLERDDfeALFRRLWATLFSEADTDGDGRISREEFVAG 58
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
28-68 1.56e-03

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 34.38  E-value: 1.56e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 743333839  28 LDIDGSGTISPSE----------AAVDTDLMAEFIELDTDGSGELSKEEFA 68
Cdd:COG5126   42 ADTDGDGRISREEfvagmeslfeATVEPFARAAFDLLDTDGDGKISADEFR 92
EH cd00052
Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and ...
 28-70 1.96e-03

Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A hydrophobic binding pocket is formed by residues from both EF-hand motifs. The EH domain binds to proteins containing NPF (class I), [WF]W or SWG (class II), or H[TS]F (class III) sequence motifs.


Pssm-ID: 238009 [Multi-domain]  Cd Length: 67  Bit Score: 32.96  E-value: 1.96e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 743333839 28 LDIDGSGTISPSEAA-------VDTDLMAEFIEL-DTDGSGELSKEEFANY 70
Cdd:cd00052   8 LDPDGDGLISGDEARpflgksgLPRSVLAQIWDLaDTDKDGKLDKEEFAIA 58
PPP2R3C cd21505
serine/threonine protein phosphatase 2A regulatory subunit B" subunit gamma; Heterotrimeric ...
 46-70 4.80e-03

serine/threonine protein phosphatase 2A regulatory subunit B" subunit gamma; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. This subfamily includes protein phosphatase subunit G5PR (also known as serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma, G4-1, G5pr, GDRM, SPGF36, or C14orf10) that is encoded by the PPP2R3C gene. It is involved in the control of the dynamic organization of the cortical cytoskeleton and plays an important role in the organization of interphase microtubule arrays in part through the regulation of nucleation geometry. G5PR is involved in the ontogeny of multiple organs, especially critical for testis development and spermatogenesis. PPP2R3C gene variants cause syndromic 46,XY gonadal dysgenesis and impaired spermatogenesis in humans, and thus is emerging as a potential therapeutic target for male infertility.


Pssm-ID: 410338 [Multi-domain]  Cd Length: 382  Bit Score: 33.31  E-value: 4.80e-03
                         10        20
                 ....*....|....*....|....*
gi 743333839  46 DLMAEFIELDTDGSGELSKEEFANY 70
Cdd:cd21505  222 RVYGQYLNLDKDHNGMLSKQELSRY 246
XopAW NF041410
XopAW family type III secretion system calcium-binding effector;
28-69 7.98e-03

XopAW family type III secretion system calcium-binding effector;


Pssm-ID: 469301 [Multi-domain]  Cd Length: 227  Bit Score: 32.73  E-value: 7.98e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 743333839  28 LDIDGSGTISPSE---AAVDT-------DLMAEFIELDTDGSGELSKEEFAN 69
Cdd:NF041410  36 LDSDGDGSVSQDElssALSSKsddgsliDLSELFSDLDSDGDGSLSSDELAA 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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